Pharmacology, Toxicology and Environmental Health Commons^™

Evaluation Of The Phytochemical Components And In Vitro Anti-Inflammatory Activities Of Eucalyptus Camaldulensis, Nwankwo Henry Chukwuebuka, Oladipo Miriam Oluchi, Oladipo Bamidele Fatai, Onmata Gloria Deborah, Agbo Joseph Odeh, Agu, Solomon Tsekohol, Onyeyili Patrick Azubuike

Bulletin of Faculty of Pharmacy Cairo University

Phytochemicals such as alkaloids, flavonoids, and terpenoids are known for their medicinal properties, including anti-inflammatory effects. This study analyzed the phytochemical composition of Eucalyptus camaldulensis leaf extracts and evaluated its’ in vitro anti-inflammatory potential. Leaves of E. camaldulensis were collected, authenticated and extracted using 70% methanol. Qualitative and quantitative phytochemical analyses were performed using standard protocols. Total phenolic content (68.68 ± 0.001 mg/100g), flavonoids (279.62 ± 0.18 mg/100g), alkaloids (82.17 ± 0.76 mg/100g), tannins (22.79 ± 0.03 mg/100g), and terpenoids (8.43 ± 0.03 mg/100g) were quantified. Anti-inflammatory assays included albumin denaturation inhibition (76.33 ± 0.19% at 50 mg/mL), proteinase inhibition …

Immunomodulatory Activity Of Bryonia Alba 6c And 30c In Sheep Red Blood Cell-Immunised Mice: Insights From Humoral And Delayed-Type Hypersensitivity Responses, Abanti Goswami, Narasimha Kumar Gv, Vara Prasad Saka, Suneel Prajapati, Bibaswan Biswas, Pankaj Gupta

Indian Journal of Research in Homoeopathy

Background: Malnutrition and infectious diseases compromise immune responses, increasing vulnerability to infections. The introduction of plant-derived immunomodulators, such as Bryonia alba (Bry. alba), is attracting attention due to their lower side effects compared with chemical drugs. In Homoeopathy, Bry. alba has long been utilised to treat a wide range of illnesses, including viral infections, and is recognised for its immunomodulatory properties. Objectives: To evaluate the immunomodulatory effects of Bry. alba 6C and 30C potencies on humoral and delayed-type hypersensitivity (DTH) in sheep red blood cell (SRBC)-immunised BALB/c mice. Materials and methods: Fifty BALB/c mice were divided into five …

Chemical Composition And Mechanism Investigation Of Subfraction From Wuwei Zijin San Guided By Anti-Hepatic Fibrosis Activity, Yazhen Guo, Zhongzhi Qi, Yajuan Chen, Lijuan Nie, Mingyu Luo, Yuechen Guo, Hui Wu, Bengui Ye, Jun He

Journal of Food and Drug Analysis

BACKGROUND  Among the spectrum of hepatopathies that pose a significant global health threat, halting the progression of hepatic fibrosis is a key therapeutic objective. Wuwei Zijin San (WWZJS) is derived from a traditional Tibetan empirical formula, yet its efficacy against hepatic fibrosis, along with the underlying mechanisms and active ingredients, remains uncertain.

PURPOSE  The aim of this study was to investigate the protective effect of WWZJS against hepatic fibrosis, explore its underlying mechanisms and material basis, and evaluate the potential of direct interactions between the biologically active ingredients and their corresponding targets.

METHODS Chemical profiling of the active …

Simotang Oral Liquid Alleviates Functional Dyspepsia-Related Motility Dysfunction Through Ca²⁺-Dependent Smooth Muscle Contraction And Nrf2/Nf-Κb Modulation, Guo Mao, Chunxiang He, Jiaqin Liu, Dahua Wu, Puhua Zeng, Ye Mao

Journal of Food and Drug Analysis

Functional dyspepsia (FD) is a disorder of gut-brain interaction involving heterogeneous motor, sensory, immune, and oxidative stress-related mechanisms. Simotang oral liquid (SMT), a traditional Chinese medicine formulation used for dyspeptic and gastrointestinal motility-related symptoms, has not been evaluated with an integrated clinical, functional, and molecular framework. This single-arm prospective pre-post study assessed gastric emptying by the 13C-octanoic acid breath test, gastric electrical activity by electrogastrography, postprandial tolerance by nutrient drink testing, symptom scores, serum biomarkers, and gastric antral tissue markers in patients with FD. FD-like mice were used for charcoal meal transit, smooth muscle strip tension, calcium channel blockade, and …

Integration Of Freshness Monitoring And Active Packaging Technologies For Aquatic Products, Maria Ali, Abdul Waheed Ghanghro, Bheem Raj Serani, Mahrukh Zakir

Journal of Food and Drug Analysis

Aquatic products are nutritionally valuable but highly perishable, with quality loss driven by microbial spoilage, biochemical changes, including total volatile basic nitrogen (TVB-N), trimethylamine (TMA) and histamine, and physicochemical deterioration, including lipid oxidation, gas production and texture loss. Conventional packaging slows these processes but does not report real-time freshness. This review analyzes how active packaging (antimicrobial, antioxidant, enzyme-inhibiting, and oxygen-scavenging systems, including bio- and nanocomposites) can be combined with freshness monitoring technologies (colorimetric/pH indicators, gas sensors, biosensors, and digital tools such as radio frequency identification (RFID) and Internet of Things (IoT) systems) specifically for fish, shrimp, and mollusks. We first …

A Target-Responsive And Signal-Amplified Dna Hydrogel Biosensor For Visual And Quantitative Detection Of Aflatoxin B1, Haojie Du, Haoyue Liu, Yongshuai Li, Shiyi Wei, Xinning Wang, Yunxuan Weng, Xiaoying Zhao

Journal of Food and Drug Analysis

Aflatoxin B1 (AFB1) poses a severe threat to food safety due to its potent carcinogenicity. To address the need for rapid and on-site detection, this study developed a colorimetric biosensor based on an AFB1-responsive DNA aptamer-cross-linked sodium alginate hydrogel. Gold nanoparticles (AuNPs) were encapsulated within the hydrogel as a visual signal reporter. The sensing mechanism relies on target-induced dissociation of aptamer crosslinkers, leading to hydrogel disintegration and release of AuNPs. The hydrogel formulation was optimized regarding sodium alginate concentration and crosslinking conditions. To enhance sensitivity, an Exonuclease I (Exo I)-triggered target recycling strategy was implemented, which amplifies hydrogel network disruption …

Identification Of Ca2 As A Potential Candidate Gene Involved In The Therapeutic Effect Of Huatan Huoxue Decoction On Polycystic Ovary Syndrome: An Integrated Study Of Network Pharmacology, Mendelian Randomization, And Experimental Validation, Chan Zhu, Yijin Zhang, Panwei Hu, Cong Qi, Qiu Chen, Hong Yang, Jing Li

Journal of Food and Drug Analysis

Purpose: Huatan Huoxue decoction (HTHXD) is effective in treating polycystic ovary syndrome (PCOS); however, its underlying mechanisms of action remain unclear. Methods: Gene targets were obtained through Mendelian randomization (MR) analysis using druggable genes from public databases and genome-wide association study data for PCOS from the FinnGen R12 database. These targets were integrated with the active ingredients and protein targets of HTHXD retrieved from the TCMSP and BATMAN-TCM databases for network pharmacology analysis. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted. Core targets were validated using molecular docking. Experimental validation was performed using a letrozole-induced …

An Observational Study Of The Effect Of Concomitant Levetiracetam On Apixaban Concentrations In A Hospital Cohort, Chazmyn Riley, Kevin Lam, Cristina Micale, Lynda Thomson, Douglas F. Stickle, Walter K. Kraft

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Despite the lack of evidence of a mechanism-based drug interaction, some professional organizations have advised caution coadministering apixaban and levetiracetam. Eligible patients taking apixaban with or without levetiracetam for any indication for at least 72 h were screened from the electronic medical records. Plasma samples from 77 patients were retrieved from salvaged clinical blood collections. Apixaban minimum and maximum concentrations (Cmin and Cmax) were compared using descriptive statistics in R. While the median Cmin and Cmax appear to be marginally elevated, there were no apparent differences relative to apixaban alone. These findings suggest no apparent interaction of levetiracetam and support …

The Correlation Between Medication Adherence, Blood Glucose Levels, And Quality Of Life In Patients With Type 2 Diabetes Mellitus At Ciamis Regional Hospital, Amyla Putri Nurul Nazmi, Nur Rahayuningsih, Lusi N

Pharmacology and Clinical Pharmacy Research

Type 2 diabetes mellitus is a chronic condition requiring continuous treatment, including patient adherence to prescribed medication. This study aimed to explore the relationship between medication adherence, blood glucose levels, and quality of life in patients with type 2 diabetes mellitus at Ciamis Regional Hospital, conducted from January to March 2025, the research employed a quantitative, prospective cross-sectional design involving 49 hospitalized patients. Data included blood glucose levels (RPG, FPG, 2hPG), medication adherence measured using the Medication Adherence Report Scale (MARS-5), and quality of life assessed via the Diabetes Quality of Life-Brief Clinical Inventory (DQOL-BCI). The chi-square test was used …

The Phytochemical Content And Antibacterial Activity Of Purified Extract Of Mangifera Indica L. Against Gram Positive Pathogen, Dewi Andini Kunti Mulangsri, Masduki Faqih, Sugar Arifin, Mutiara Trie Sieya Agustin

Pharmacology and Clinical Pharmacy Research

The purified extract of arum manis mango leaves contained flavonoid compounds by TLC methods and antibacterial activity against Gram-positive and negative pathogens. This research aimed to identify and determine the phytochemical content (mangiferin and flavonoids content) and antibacterial activity against other Gram-positive pathogens. Purification of ethanol extract of arum manis mango leaves by liquid-liquid fraction method. Determination of total flavonoid content and identification of mangiferin used respectively by aluminum chloride and Thin Layer Chromatography method. The disk diffusion method was used to assay antibacterial activity against S. epidermidis, and B. subtilis bacteria with the concentration of the sample such …

Innovating A Crustacean Embryo Toxicity (Cet) Assay For Screening Environmental Contaminants, Irina A. Polunina-Proulx

Graduate Doctoral Dissertations

Environmental pollutants can disrupt normal developmental processes, leading to neurobehavioral and developmental abnormalities. Toxicity tests are important for evaluating environmental contaminants; however, standard assays are often time- and cost-intensive and typically require large numbers of vertebrate animals. These limitations highlight the need to reduce reliance on vertebrate testing and to develop New Approach Methodologies that provide comparable results while improving efficiency and cost-effectiveness. This research utilizes a novel screening assay to evaluate developmental toxicity using Hyalella azteca. H. azteca is a freshwater amphipod widely used as a model organism for sediment toxicity in ecotoxicology, yet its embryos have been minimally …

Spider Biodiversity And Insecticide Sensitivity Across Active And Restored Cranberry Bogs On Nantucket, Tyler J. Kulak

Graduate Masters Theses

Spiders are one of the most diverse groups of organisms on the planet with over 53,000 species described as of 2026. They provide a suite of ecosystem services including their regulation of problematic pests in agricultural systems, appearing in high biomasses across a breadth of ecological niches. While beneficial as pest regulators, they are also susceptible to the same management techniques as pest organisms and are especially vulnerable to chemical control. Cranberry production in Massachusetts likely benefits from spider ecosystem services, but diversity research on spiders in these systems is limited. This study compares the diversity of spider populations from …

Data Curation And Integration For Cancer Cell Line Pharmacogenomics Analysis, Meric Kinali

Graduate Masters Theses

Cancer cell lines are essential resources for connecting genomic and molecular features with drug response and identifying biomarkers. Therefore, large-scale cancer cell line resources have been growing, but this introduces challenges such as data standardization, consistent annotation, matching identifiers, cross-database integration, and a reproducible computational framework. CellMiner Cross Database (CellMinerCDB) integrates pharmacogenomic datasets from multiple resources and provides a standardized analysis of cell lines across datasets. This thesis examines cancer cell line cross-databases and their importance in pharmacogenomics, with a particular focus on CellMinerCDB. As part of this work, I developed an R package for the gCSI (Genentech Cell Line …

Genomic Based Environmental Health Assessment: Vieques, Puerto Rico, Valeria Hernandez Talavera

Graduate Doctoral Dissertations

From 1941 to 2003, the United States Navy and North Atlantic Treaty Organization (NATO) used Vieques, Puerto Rico, for military training, which led to long-term pollution from metals, organic chemicals, explosives, and per- and polyfluoroalkyl substances (PFAS). While earlier research found these contaminants in the environment and in living organisms, their combined effects on local ecosystems remain poorly understood.

This dissertation used a Genomic-Based Environmental Health Assessment (GEHA) framework to study the ecological risks from past military pollution in Vieques. The approach combined sediment toxicity tests, chemical analysis, gene expression studies, microbial community analysis, and community-based research. The four main …

Cost Effectiveness Analysis Of Psychopharmaca Therapy Combination Compared With Psychopharmaca Therapy And Ect Combination In Schizoaffective Inpatients At The Rsj Provinsi Jawa Barat, Yasmin Fadillah, Sani Asmi Ramdani Lestari, Ardilla Kemala Dewi

Pharmacology and Clinical Pharmacy Research

Mental disorders constitute an economic burden on health, estimated at USD 2.5 trillion in 2010 and expected to increase to USD 6 trillion by 2030. Treatment of schizoaffective disorder involves a combination of medication and psychotherapy. Pharmacoeconomics is an important consideration in drug selection. This study aims to determine the cost-effectiveness of psychopharmaca therapy combination compared with psychopharmaca therapy and ECT combination in schizoaffective inpatients at the RSJ Provinsi Jawa Barat. Data collection was conducted retrospectively from patient medical records for the period December 2023–December 2024. Total costs, based on a health perspective, include psychopharmaca drug costs, inpatient care costs, …

Evaluation Of Antibiotic Use Using The Gyssens Method On Clinical Outcomes In Ischemic Stroke Patients, Juniarto Mende, Graciano A. Maturbongs, Yohana K. A. Mbulang

Pharmacology and Clinical Pharmacy Research

Ischemic stroke is a health problem that causes death and neurovascular disability worldwide. The inflammatory response due to infection can increase ischemic stroke and increase brain damage through changes in blood pressure, coagulation, immune response, and endothelial function. This study aims to evaluate the rationality of antibiotic use on clinical outcomes in ischemic stroke patients. This study used a cross-sectional design. Retrospective data were taken from the medical records of Jayapura Regional Hospital for the period January 1, 2023, to May 31, 2025. The study subjects were all patients who suffered ischemic stroke and received antibiotics. Evaluation of the rationality …

Retrospective Analysis Of Antimicrobial Resistance Patterns In Gram-Positive And Gram-Negative Blood Isolates, Helman Kurniadi, Timbul Partogi Haposan Simorangkir, Ros Sumarny, Fitria Heldiana

Pharmacology and Clinical Pharmacy Research

Bloodstream infections are an important cause of morbidity and mortality, while antimicrobial resistance limits treatment options. This retrospective study evaluated bacterial distribution and antimicrobial susceptibility in blood cultures at RSPAD Gatot Soebroto, Jakarta, using microbiology and medical record data from January-December 2019. Clinically significant isolates were included, while duplicates and contaminants were excluded. Identification and susceptibility testing followed standard procedures and CLSI 2019 guidelines. Data were analyzed descriptively. Among 482 isolates, 246 (51.0%) were Gram-positive and 236 (49.0%) were Gram-negative. The Gram-positive isolates were mainly coagulase-negative staphylococci, including Staphylococcus epidermidis (62, 25.2%), S. hominis (61, 24.8%), and S. haemolyticus (50, …

Analysis Of Pharmacotherapy And Non-Pharmacotherapy Burden From The Ina-Cbgs Package For Cesarean Section Surgery At The Regional General Hospital Dr. Soedarso In 2023, Ananda Rizky Awwaliyah, Nurmainah Nurmainah, Ridha Ulfah

Pharmacology and Clinical Pharmacy Research

The prevalence of cesarean sections has been increasing each year. Previous studies show that the cost of medications and medical supplies for cesarean patients accounts for one-third of the total care costs. In the era of National Health Insurance (NHI), medications and medical supplies are considered operational expenses for hospitals rather than sources of income. This condition requires proper medication management and the use of medical supplies. This study aims to analyze the percentage of pharmacotherapy and non-pharmacotherapy, including the types and quantities of medications as well as disposable medical supplies used on patients undergoing cesarean section procedures at the …

Alexithymia In Substance Use Disorders: A Scoping Review Of Therapeutic Approaches, Pratami Diah Herliani, Shelly Iskandar, Angela Vera Herman Efendi

Pharmacology and Clinical Pharmacy Research

Alexithymia, defined as the inability to recognize and express emotions, has a high prevalence (40–50%) among individuals with substance use disorders (SUD), particularly alcohol use disorder, and is associated with poorer clinical outcomes. Despite this, comprehensive mapping of psychotherapeutic interventions targeting this condition within the SUD population remains limited. This study aimed to systematically map the therapeutic approaches investigated to address alexithymia among individuals with substance use disorders and to summarize the reported outcomes. A scoping review was conducted in accordance with the PRISMA-ScR guidelines using systematic literature searches in the PubMed and Scopus databases. Relevant studies were screened based …

Outcome Evaluation Of Percutaneous Coronary Intervention Vs Medical Therapy Alone In Patients With Chronic Coronary Syndrome, Hsien-Yuan Chang, Hsin-Yu Fang, Mu-Shiang Huang, You-Zhen Chen, Di-Yung Chen, Edward Chia-Cheng Lai, Jung-Der Wang, Yi-Heng Li, Li-Jung Elizabeth Ku

Journal of Food and Drug Analysis

This study provides real-world evidence by comparing the long-term clinical outcomes of percutaneous coronary intervention (PCI) versus medical therapy alone in patients with chronic coronary syndrome (CCS) diagnosed non-invasively, given the lack of evidence in this population. This retrospective cohort study (2013-2018) utilized data from a medical center’s Cardiovascular Disease Databank, which was linked to national mortality records in Taiwan. Propensity score matching (PSM) and stabilized inverse probability of treatment weighting (IPTW) were applied to adjust for baseline differences between the PCI and medication-only groups. Major adverse cardiovascular events (MACE), including all-cause mortality, non-fatal myocardial infarction (MI), and revascularization, were …

Sporicidal Activity Mechanism Of Lactic Acid And Peracetic Acid On Bovine Pathogenic Bacillus Cereus Spores, Xin Zhang, Yunjiao Chen, Jingjing Zhao, Haiying Zheng, Lanlan Liu, Wei Liu, Mingshan Fu, Weijuan Jia, Zelin Jia, Jiayu Cui, Yuhang Zhang, Huisheng Xiong, Yujie Ma, Xueli Wang, Haifeng Wang

The Thai Journal of Veterinary Medicine

In recent years, the pathogenicity of Bacillus cereus (B. cereus) has increased significantly, its host adaptability has continued to expand, and the infection spectrum has also expanded. At the same time, food contamination by B. cereus is also common. Therefore, it is of practical significance to select green, safe and effective inhibitors. Lactic acid (LA) and peroxyacetic acid (PAA) possess good antibacterial properties, making them environmentally friendly, safe, and non-toxic. The purpose of this experiment was to preliminarily explore the inhibition mechanism of LA and PAA on B. cereus spores. The effects of LA and PAA on B. …

The Effects Of Hypoxia On Balance Systems, Samuel Drescher Drescher, Heather Bond, Allysa Hayden, Victoria Cornaro, Brandon Ibarra, Noah Clark, Frank Cunningham Iv, Carolina Ferreira, Sierra Martinez, Katie Stubits

Discovery Day - Daytona Beach

Hypoxia, a condition characterized by insufficient oxygen availability to body tissues, is known to impair physiological and cognitive function, particularly at high altitudes above 15,000 ft. However, the effects of mild hypoxia (10,000–15,000 ft) remain less well understood. This study, conducted by the department of Human Factors and Behavioral Neurobiology at Embry-Riddle Aeronautical University, investigates the impact of mild hypoxia at 12,000 ft on human balance systems. Specifically, it examines the three primary components of balance: visual, proprioceptive, and vestibular systems. Participants complete nine balance tasks under both normoxic and hypoxic conditions. Tasks are structured to progressively limit sensory input: …

Evaluation Of Antimicrobial Resistance In Pathogens Relevant To Long-Duration Space Missions, Natalie Brattain, Yegor Bushnev, Mikayla M. Dutkiewicz

Discovery Day - Daytona Beach

Antimicrobial resistance is a growing global concern that necessitates the development of effective strategies for selecting appropriate antibiotics, especially in the context of future long-duration space missions, where infection control and treatment options are limited. This study employs the Kirby–Bauer disk diffusion assay to evaluate the antimicrobial susceptibility of Pseudomonas aeruginosa and other clinically and spaceflight-relevant bacterial pathogens such as Klebsiella pneumoniae, Staphylococcus aureus, and Streptococcus pneumoniae. These pathogens will be tested with commonly used antibiotics and potential natural compounds.   The pathogens will be cultured and isolated onto Mueller–Hinton agar plates. Antibiotic disks, along with various flavonoids disks, such as …

Evaluating The Potential Of Cajanus Cajan (L.) Millsp. Root To Improve Atopic Dermatitis With Different Anti-Inflammatory Models And Active Compounds, Shu-Er Yang, Xiang-Ming Cai, Yu-Wen Chu, Jen-Chieh Tsai, Mey-Fann Lee, Tuzz-Ying Song

Journal of Food and Drug Analysis

Atopic dermatitis (AD) is a chronic inflammatory disease characterized by recurrent bacterial infections that cause pruritus, erythema, xerosis and thickening. Cajanus cajan root extract prepared with 95% ethanol (EECR95) has been shown to possess antioxidant, anti-inflammatory, and antibacterial properties in previous studies. This study aimed to evaluate EECR95’s ability to improve AD by inhibiting methicillin-resistant Staphylococcus aureus (MRSA) growth and reducing inflammation. This study found EECR95 effectively inhibits MRSA growth (IC₅₀ = 103.74 μg/mL) and reduces pro-inflammatory cytokine production in an MRSA-keratinocyte-macrophage model. LC/MS/MS analysis revealed the presence of active compounds- flavonoids, isoflavones, and flavonoid glycosides, highlighting EECR95's potential …

From Sunscreen To Seafood: Tracing The Ecological And Human Health Risks Of Oxybenzone Contamination In Local Fish, Alyssa Brasko

Discovery Day - Daytona Beach

Oxybenzone (benzophenone-3) is a widely used ultraviolet (UV) filter in sunscreens, offering protection against harmful radiation but raising significant environmental concerns due to its persistence and toxicity in aquatic ecosystems. This ongoing study aims to investigate the bioaccumulation and ecological impact of oxybenzone in fish species along Florida’s Space Coast, contributing to a broader understanding of its environmental fate and potential human exposure through seafood consumption. The research will employ advanced analytical techniques, including Gas Chromatography-Mass Spectrometry (GC-MS) and High-Performance Liquid Chromatography (HPLC), to quantify oxybenzone levels in locally sourced fish. Fish samples will be obtained from the non-profit organization …

In Vitro Digestion Modifies Lepidium Meyenii Extract, Altering Its Major Glucosinolates, Lepidilines, Β-Carbolines, And Gut Bacterial Growth, Dominik Tarabasz, Ewa Baranowska-Wójcik, Paweł Szczeblewski, Tomasz Laskowski, Klaudia Gustaw, Marzena Furtak-Niczyporuk, Dominik Szwajgier, Rita Cristina Orihuela-Campos, Henry O. Meissner, Julia Borzyszkowska-Bukowska, Wirginia Kukula-Koch

Journal of Food and Drug Analysis

The tubers of Lepidium meyenii (commonly known as maca) have been used in the Andean cuisine for ages. The study aims to determine the behavior of the extract from the red phenotype of maca in the in vitro gastrointestinal tract model and also to define the overall impact of the extract on the microbiota. Glucosinolates, lepidilines, and a derivative of β-carboline alkaloid, i.e. 1-methyltetrahydro-β-5,6-hydride-carboline-3-carboxylic acid, as representatives of one of the main groups of metabolites were selected for the quantitative analysis after in vitro digestion at every stage of the digestion model. The results showed that lepidilines …

Urinary Antimony As A Biomarker For Differentiating Heroin And Brown Mixture Use, Shu-Mei Tsai, Yu-Han Hsiao, Yan-Zin Chang, Sai-Wai Ho

Journal of Food and Drug Analysis

Heroin is classified as a Schedule I controlled substance with severe legal consequences for its use, whereas liquid Brown Mixture (BM) is a legally available and commonly prescribed cough remedy in Taiwan. However, numerous cases of BM ingestion have been misinterpreted as heroin use because BM contains opium tincture, leading to similar urine test results. Owing to the rapid metabolism of heroin, detection of the parent drug and its primary metabolite, 6-acetylmorphine, in urine is difficult; thus, interpretation often relies on morphine concentration and the morphine-to-codeine (M/C) ratio, which can be inconclusive. In our BM analysis, the M/C ratio was …

Evaluating The Relationship Between Naltrexone Systemic Exposure And Acute Brain Response Using A Neuroimaging-Based Pharmacodynamic Biomarker, Trisha Rastogi, Stephani Stancil, Susan M. Abdel-Rahman, Michael Bartkoski, James Bartolotti, Mariah E. Brewe, William Brooks, Morgan Brucks, Anna Burns, Ann M. Davis, Laura Martin, Jeffrey R. Strawn, John Tumberger, Michaela Voss, Hung-Wen Yeh

Posters

No abstract provided.

Integrating Space Use And Demography To Support Management Of An Endangered Alpine Ungulate, Danielle J. Berger

All Graduate Theses and Dissertations, Fall 2023 to Present

The places animals choose to live affect the food they find, the dangers they face, and the weather conditions they experience. These experiences influence whether individual animals survive and reproduce, which in turn affects the size and health of animal populations. Although scientists have long believed that animal movements play an important role in population trends, there has been limited real-world evidence showing this connection. Advances in GPS tracking technology now allow researchers to follow animals over long periods and better understand how movement influences survival. Using 20 years of GPS tracking data from the endangered Sierra Nevada bighorn sheep …

Understanding And Predicting Precipitation Characteristics In The United States Through Machine Learning, Numerical Modeling And Measurements, Cody Luther Ratterman

All Graduate Theses and Dissertations, Fall 2023 to Present

Precipitation is one of the most important yet uncertain variables in the climate system. It varies dramatically in terms of timing, accumulation, rate, and phase, depending on location, season, circulation patterns, and atmospheric conditions. Precipitation forecasts, especially snowfall, are essential to supporting drought mitigation and water management in the Intermountain West. Because rainfall and snowfall lead to opposite effects on snowpack, accurately partitioning rain and snow is important to estimate snowpack levels, winter recreation, mountain ecosystems and runoff. The research findings in this dissertation have advanced the understanding and prediction of precipitation and snowpack in the U.S. by addressing the …