Digital Commons Network^™

Body Force Influence On Healthy And Diseased Red Blood Cell Sedimentation Using Multiphase Cfd Methods, Gerald Gallagher, Fergal J. Boyle

Research Outputs: 2025-Present

The accurate simulation of blood, which is a multiphase biofluid comprised of plasma and cellular components, is important for biomedical applications. Computational fluid dynamics is routinely used for blood simulation but traditionally treats the flow field as homogeneous. Red blood cell dynamics and deformation are important as they occupy approximately 45% of the volume in blood and control viscosity and non-Newtonian behaviour. Healthy and diseased red blood cells differ in shape and properties, and an understanding of the behaviour of these cells in flow allows for better insight into in-vitro and in-vivo applications such as early-stage disease identification, non-chemical cell …

Dna Methyltransferase Inhibitors In Hematological Malignancies And Solid Tumors, Valentin Wenger, Guillermo Garcia-Manero, Robert Zeiser, Michael Lübbert

Faculty, Staff and Student Publications

Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5-position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor suppressor genes, oncogenes, and other key regulatory genes. The first-generation DNMTi azacitidine and decitabine have demonstrated substantial efficacy in the treatment of medically non-fit, older patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy (IC), by virtue of their favorable safety profile. Despite these clinical achievements, however, single-agent DNMTi treatment …

Epigenome-Wide Association Study Meta-Analysis Of Bmi In African Americans, Kendra Ferrier, Mariaelisa Graff, Iain R Konigsberg, Maggie Stanislawski, Heather M Highland, April P Carson, Jill M Norris, Chris R Gignoux, Audrey E Hendricks, Sridharan Raghavan, Kari E North, Kristin L Young, Anne E Justice, Matthew A Allison, Mathew J Budoff, Silva Kasela, François Aguet, Joshua J Joseph, Charles Kooperberg, Stephen S Rich, Jerome I Rotter, Ethan M Lange, Leslie A Lange

Faculty, Staff and Student Publications

Despite considerable advances in identifying risk factors for obesity, gaps remain in our understanding about its etiology. Genetic variants explain only a small portion of variation in obesity-related traits such as body mass index (BMI). Epigenetic regulation, which controls gene expression and is influenced by environmental and genetic factors, may account for additional variability in BMI. Epigenetic studies of BMI have largely been conducted in European ancestry populations, despite the disproportionate burden of obesity in African Americans (AAs). We conducted a sex-stratified BMI epigenome-wide association study meta-analysis in AA participants from the Jackson Heart Study (n = 1,604) and …

Bridging Hypoxia And Vision Loss: The Emerging Role Of Connexins In Local And Systemic Eye Diseases, Xianping Zhang, Yalong Cheng, Jean X Jiang, Yuting Li

Faculty, Staff and Student Publications

Hypoxic eye diseases represent a pivotal yet often underappreciated contributor to the onset and progression of many retinal disorders. When hypoxia persists or exceeds the tissue's compensatory capacity, it triggers pathological retinal neovascularization, blood-retinal barrier disruption, and neuronal apoptosis, ultimately resulting in irreversible visual impairment. Connexins (Cxs) form gap junction channels and hemichannels and regulate retinal cell proliferation, differentiation, and survival, thereby playing a central regulatory role in the pathogenesis of hypoxic ocular diseases. In addition to gap junctions, Cx hemichannels promote transmission of molecules between intra- and extracellular environments, further influencing retinal homeostasis under hypoxic stress. This review synthesizes …

Epilepsy Disease Classification: A Community Effort To Enhance The Mondo Disease Ontology, Nicole Vasilevsky, Sarah Gehrke, Kathleen Mullen, Subit Barua, Ian Braun, Tobias Brünger, Curtis Coughlin, Alina Ivaniuk, Daniel Korn, Dennis Lal, Stephanie Marsh, Elaine O'Loughlin, Daniel Olson, Yousif Shwetar, Christalena Sofocleous, Vanessa Vogel-Farley, Heidi Grabenstatter, Melissa Haendel, Christopher Mungall, Sabrina Toro

Faculty, Staff and Student Publications

Motivation: Epilepsy is a diverse group of neurological disorders affecting over 50 million people worldwide. While common epilepsy types are well studied, rare epilepsies-often severe and genetically complex-pose significant challenges in diagnosis, research, and treatment. Accurate and interoperable etiology and disease classifications are critical for improving data sharing, supporting clinical decision-making, and advancing rare disease research.

Results: To enhance the accuracy of epilepsy-related disease concept representation within the Mondo Disease Ontology (Mondo), we conducted a series of expert-driven workshops in collaboration with the team from the Rare Disease Cures Accelerator-Data and Analytics Platform (RDCA-DAP). Specialists in epileptology, genetics, neurodevelopment, biomedical …

Retention On Buprenorphine For Opioid Use Disorder In Justice-Involved Individuals: A Retrospective Cohort Study, James R Langabeer, Tiffany Champagne-Langabeer

Faculty, Staff and Student Publications

Criminal justice system (CJS) involvement is common among individuals with opioid use disorder (OUD), yet limited research examines retention in medications for OUD (MOUD) within community settings. This study assessed whether CJS involvement predicted retention on buprenorphine/naloxone and explored related demographic and clinical factors. A retrospective cohort included adults (n = 367) enrolled in a low-barrier outpatient MOUD program in Texas (January 2022–April 2024). CJS involvement was identified from program records. Retention was measured as the number of continuous days with buprenorphine/naloxone prescriptions. Analyses used univariate tests, logistic regression, and nonparametric kernel regression. Nearly one-quarter (24.8%) were CJS-involved. Retention at …

The Impacts Of Age-Related Peripheral Hearing Loss, Central Auditory Processing, And Cognition On Quality Of Life In Older Adults: A Scoping Review, Brian M. Kreisman, Samantha E. Vasquez, Anna J. Bierma

University Faculty Publications and Creative Works

This scoping review aims to synthesize peer-reviewed literature exploring quality of life (QoL) for individuals with age-related hearing loss (ARHL), age-related central auditory processing (ARCAP) deficits, and age-related cognitive decline. A growing body of research has identified ARHL as a risk factor for the development of dementia, highlighting the connection between the sensory and cognitive systems. As the aging population continues to grow, examining comorbid age-related hearing and cognitive decline is especially relevant. These conditions may have potential negative consequences on the daily functioning, social participation, mental health, and overall wellbeing of older adults. A systematic search of peer-reviewed literature …

Academic Standards Subcommittee Agenda January 15, 2026, Utah State University

Educational Policies Committee

• Welcome and approval of December 18, 2025 minutes
• Discussion Topics:
• Continued discussion on the proposal to add Bachelor of Applied Sciences (BAS) academic degree requirements
• Preliminary discussion of potential policy adjustments
• Incomplete grade policy
• Pass (P), D+, D, F Option policy
• Next Meeting: Thursday, February 19, 2026

Tennessee Technological University, December 2026, Tennessee. Comptroller Of The Treasury.

Financial and Compliance Audit Reports

No abstract provided.

Whole Genome Sequence Analysis Of Pulmonary Function And Copd In 44,287 Multi-Ancestry Participants, Wonji Kim, Lucinda Antonacci-Fulton, Susan K Dutcher, Et Al.

2020-Current year OA Pubs

BACKGROUND: Whole genome sequence (WGS) data in multi-ancestry samples supports discovery of low-frequency or population-specific genetic variants associated with chronic obstructive pulmonary disease (COPD) and lung function.

RESULTS: We performed single variant, structural variant, and gene-based analysis of pulmonary function (FEV

CONCLUSIONS: Large-scale multi-ancestry WGS analysis improves variant discovery and fine-mapping resolution for lung function and COPD and highlights biologically relevant genes and pathways.

August Crossroads, Jennifer Cormack

CLAMANTIS: The MALS Journal

No abstract provided.

Unnatural Language, Cosima Pellis

CLAMANTIS: The MALS Journal

No abstract provided.

Going Back To The Ruins, Zuhura -

CLAMANTIS: The MALS Journal

No abstract provided.

Untitled, Ilyse Horlings

CLAMANTIS: The MALS Journal

No abstract provided.

White List, Reng Zhao

CLAMANTIS: The MALS Journal

No abstract provided.

The Lagoon Nebula, Ed Ting

CLAMANTIS: The MALS Journal

No abstract provided.

Constructing Hybrid Identities: Cultural Negotiation And Belonging In Uzma Jalaluddin's Ayesha At Last, Chelsee M. Niebergall

CLAMANTIS: The MALS Journal

No abstract provided.

Birthday, Ed Ting

CLAMANTIS: The MALS Journal

No abstract provided.

How To Love This World, Cosima Pellis

CLAMANTIS: The MALS Journal

No abstract provided.

Running, Isabella Campesi

CLAMANTIS: The MALS Journal

No abstract provided.

A Sound At Low Tide, Keehan White

CLAMANTIS: The MALS Journal

No abstract provided.

Unexpected Chicken Soup, Keehan White

CLAMANTIS: The MALS Journal

No abstract provided.

Momentos, Isdaly Reyes

CLAMANTIS: The MALS Journal

No abstract provided.

Running Is Flying, Madeleine Burns

CLAMANTIS: The MALS Journal

No abstract provided.

Fortitude, Jennifer Cormack

CLAMANTIS: The MALS Journal

No abstract provided.

A Year Alone In The Forest, Cosima Pellis

CLAMANTIS: The MALS Journal

No abstract provided.

Within Memory, Keehan White

CLAMANTIS: The MALS Journal

No abstract provided.

Celestial Nation, Caden Ide

CLAMANTIS: The MALS Journal

No abstract provided.

Goodbye To The One Whose Heart Still Beats, Ilyse Horlings

CLAMANTIS: The MALS Journal

No abstract provided.

Silvesta Lounge, Caden Ide

CLAMANTIS: The MALS Journal

No abstract provided.