Digital Commons Network^™

Ai-Assisted Surface-Enhanced Raman Spectroscopy For Cardiovascular Diagnostics: From Plasmonic Materials To Clinical Translation, Anju Joshi, Gymama Slaughter

Center for Bioelectronics Publications

Raman spectroscopy (SERS) has emerged as a powerful analytical technique, offering molecular fingerprint specificity and ultrasensitive detection of cardiac biomarkers. Recent advances in plasmonic nanostructures, surface functionalization strategies, and flexible sensing platforms have significantly improved the analytical performance of SERS-based biosensors. In parallel, the integration of artificial intelligence (AI) and machine learning has enabled robust interpretation of complex spectral datasets, facilitating automated biomarker classification and improved diagnostic accuracy in heterogeneous biological environments. Despite these advances, the field remains fragmented, with limited integration between nanomaterial design, biomarker selection, and data-driven analysis, and persistent challenges related to reproducibility, standardization, and clinical validation. …

Modulation Of Prussian Blue Redox Signaling By Molecular Imprinting For Reagent-Free Electrochemical Detection Of Emtricitabine, Abdellatif Ait Lahcen, Gymama Slaughter

Center for Bioelectronics Publications

Reagent-free electrochemical sensors offer significant benefits for rapid, affordable point-of-care drug testing. In this study, we introduce a novel, reagent-free electrochemical sensor based on a molecularly imprinted polymer (MIP) specifically designed for the selective detection of Emtricitabine (FTC), a common antiretroviral used in HIV therapy. The sensor uses laser-induced graphene (LIG) electrodes, renowned for their high conductivity and porosity, ideal for electrochemical sensing. To enable reagent-free operation, the LIG surface was electrochemically coated with Prussian Blue, serving as a redox-active layer. Next, an MIP-PPy film was electropolymerized onto the Prussian Blue surface in the presence of FTC as a template, …

Ion-Imprinted Polymer-Based Sensors For Toxic Metal-Ion Detection In Water: Coordination Chemistry, Transduction Strategies, And Environmental Applications, Ghita Yammouri, Gymama Slaughter

Center for Bioelectronics Publications

Toxic metal contamination in aquatic environments remains a persistent threat to human health and ecosystems. Yet, the high cost, infrastructure demands, and centralized nature of conventional analytical methods constrain routine monitoring. Ion-imprinted polymers (IIPs), a subclass of molecularly imprinted polymers, have emerged as promising synthetic recognition materials for metal-ion sensing because they generate coordination-defined binding sites with high selectivity, chemical stability, low cost, and reusability. This review summarizes recent advances in Ion-imprinted polymer (IIP)-based sensing technologies for toxic metal-ion detection in water from 2016 to 2026. It examines the fundamental recognition chemistry of IIPs, major synthesis strategies used to generate …

Image-Derived 3d Hepatic Lobule Modeling Of Acetaminophen-Induced Hepatotoxicity, Rebecca Lauren Strauss

Selected Full-Text Master Theses 2021-

The liver’s highly structured vascular microarchitecture governs blood perfusion, metabolic zonation, and the spatial distribution of xenobiotic toxicity. Current computational models of hepatic drug metabolism often oversimplify this geometry, limiting their ability to capture realistic flow dynamics and cellular injury patterns. This study develops a multiscale computational framework to predict acetaminophen-induced hepatotoxicity using image-derived, three-dimensional hepatic lobule geometries. The model integrates computational fluid dynamics (CFD) with a mechanistic cellular injury module to simulate the interplay between perfusion, metabolism, and hepatocellular viability.

Realistic vascular reconstruction was achieved from histopathology liver slices, and the resulting geometry was meshed and solved using ANSYS …

Deep Learning For Eeg-Based Emotion Recognition With Temporal And Spectral Interpretability, Shruti Rameshbhai Shingala

Selected Full-Text Master Theses 2021-

Electroencephalography (EEG)-based emotion recognition has emerged as a critical component of affective computing and clinical neuroscience. Existing approaches to this problem primarily reduce the multi-dimensional EEG time series to a single averaged feature vector, thereby discarding the temporal structure of the emotional response. The present work addresses three identified gaps in the literature: the absence of temporal interpretability, the uniform use of frequency bands, and the use of single-scale temporal feature extraction. A deep learning architecture, MST-Mamba-Asym, is proposed, comprising four components: Asymmetry Attention, which encodes hemispheric asymmetry by computing signed left–right channel differences, FreqBandAttention, which learns differential weights across …

Gender, And Socioeconomic Status In School-Based Speech-Language Pathology Decision-Making For Adolescents With Traumatic Brain Injury: A Critically Appraised Topic, Geneva Renee Toledo

Selected Full-Text Master Theses 2021-

Purpose: Adolescents are at greater risk for traumatic brain injury (TBI), and TBI-related symptoms may contribute to disciplinary actions that increase their risk of entering the school-toconfinement pipeline. Given the disproportionate representation of racially marginalized male adolescents within this pipeline, this critically appraised topic (CAT) examined how race, gender, and socioeconomic status may influence school-based speech-language pathology (SLP) services and clinical decision-making following TBI. Method: A structured search of five electronic databases was conducted to identify studies examining speech-language pathologists’ (SLPs’) clinical decision-making and management of adolescents with TBI in relation to race, gender, and socioeconomic status. Relevant studies were …

Impact Of Social Media On Self Esteem And Body Image, Sunayana Sri Acharya Goribidnur Sudheendra

Selected Full-Text Master Theses 2021-

This study examined how idealized self-presentation on social media relates to self-esteem and body image in young adults, and whether body dissatisfaction, general distress, or symptoms of depression, anxiety, and stress help explain that relationship. Ninety-eight undergraduate students from two universities completed an online survey measuring idealized online self-presentation (Presentation of Online Self Scale), self-esteem (Rosenberg Self-Esteem Scale), body esteem (Body Esteem Scale for Adolescents and Adults), general distress (Distress Questionnaire-5), and depression, anxiety, and stress symptoms (DASS-21). Contrary to expectations, greater idealized self-presentation was associated with higher, not lower, self-esteem. Idealized self-presentation was not significantly related to body esteem, …

The 2025 American Society Of Pediatric Otolaryngology Workforce And Compensation Survey: Current State And Future Directions, Lyndy J. Wilcox, Cristina M. Baldassari, Amy C. Brenski, Emily Boss, John Carter, David H. Chi, William O. Collins, Charles E. Elmaraghy, Andrew J. Tompkins, Craig S. Derkay, The Aspo 2025 Workforce And Compensation Committee

Department of Otolaryngology (ENT) Faculty Publications

Objective

To provide an updated comprehensive assessment of the Pediatric Otolaryngology workforce in the United States inclusive of compensation, productivity, practice patterns, and on-call burden.

Study Design

Cross-sectional electronic survey.

Methods

A structured electronic survey was developed by members of the American Society of Pediatric Otolaryngology (ASPO) Workforce and Compensation Committee. The survey evaluated six domains: demographics, compensation, workforce dynamics, productivity, on-call burden, and future priorities, and was distributed to all 480 presumedly actively-practicing, domestic ASPO members.

Results

The survey response rate was 68% (327/480). Ninety-one percent of respondents held an academic appointment with relatively equal percentages of each rank …

Experiences Of Marginalization At The Intersection Of Race, Ethnicity, And Disability In Higher Education, Nora L. Portillo

Theses, Dissertations and Culminating Projects

Black and Latine college students with disabilities navigate higher education at the intersection of racism and ableism, yet their experiences remain underexamined. Autism and ADHD are particularly underrepresented in research and public discourse; moreover, unlike other disability categories in which students of color are overrepresented, Black and Latine children are less likely than white children to be accurately identified, and both disabilities are often framed around white prototypes. Guided by Disability Critical Race Theory, the present exploratory qualitative study used semi-structured interviews with ten undergraduates identifying as Black and/or Latine and with ADHD and/or on the autism spectrum attending a …

Editor's Note, Emily Derrenbacker

Colorado Environmental Law Journal

No abstract provided.

Table Of Contents, Colorado Environmental Law Journal

Colorado Environmental Law Journal

No abstract provided.

On Shaky Ground: America’S Public Lands Face An Uncertain Future, John Leshy

Colorado Environmental Law Journal

No abstract provided.

The Fight For Public Rights On America’S Waterways, Mark Squillace

Colorado Environmental Law Journal

No abstract provided.

Fencing In A Technological Age: Utilizing Federal Regulatory Frameworks To Implement Virtual Fencing On Federal Public Land, Sam Johnson

Colorado Environmental Law Journal

No abstract provided.

A Précis Of Pfas Legislation In The Southwestern United States, Brenden Catt

Colorado Environmental Law Journal

No abstract provided.

People Over Paper: The Effectiveness Of International Agreements Under Treaty Capture, Eric Nicholson

Colorado Environmental Law Journal

No abstract provided.

Greening With Justice: Evaluating Denver’S Urban Green Space Policies Through An Environmental Justice Lens, Vicente Tapia

Colorado Environmental Law Journal

No abstract provided.

Peak Bagging: The Land Acquisition History And Public Access Rights That Make It Mostly Possible, Andrea Shipton

Colorado Environmental Law Journal

No abstract provided.

Holding The District Together With Duct Tape And Determiniation: A Study Of Superintendent Stress, Robert Orion Thompson

Dissertations and Theses

Researchers’ work found the superintendent role was increasingly complex. Superintendents experienced elevated stress, burnout, and turnover. However, the ways in which district context and coping strategies interacted to shape superintendent well-being remain insufficiently understood, particularly in rural settings. This study examined how school superintendents perceived and experienced occupational stress, the impact of that stress on their well-being and leadership, and the coping strategies they used. Notably, there was a focus on district size differentiation. Using a qualitative research design, data were collected through two focus groups in the western side of a rural state with superintendents representing districts with large …

Shared Fate In Adult Romantic Relationships, Clement Antwi

Dissertations and Theses

Shared fate captures the extent to which individuals perceive their outcomes as yoked to those of their partner, serving as a proximal indicator of interdependence in romantic relationships. Although prior research has established the Shared Fate Scale as a measure of perceived interdependence, little is known about its psychometric properties over time within ongoing romantic relationships or whether it helps explain relationship quality. I examined these key questions using two longitudinal studies of adults in romantic relationships across three waves spanning approximately two years (N = 445 at Wave 1, N = 260 at Wave 2, and N = 181 …

Covid-19 Pandemic-Induced Social Isolation: A Hermeneutic Phenomenological Exploration Of Age And Time, Renee Reedy

Dissertations and Theses

Lockdown measures during the COVID-19 pandemic fundamentally altered social functioning, creating an urgent need to understand the lived experience of isolation across life stages. This qualitative hermeneutic phenomenological study explored how age and time shaped social isolation during the pandemic. Sixteen participants from three-generation households—adolescents (n=5), adults (n=6), and older adults (n=5)—were interviewed approximately five years post-isolation. Recruitment occurred through ResearchMatch, and interviews were conducted between February and March 2025. Participants represented diverse racial, ethnic, and geographic backgrounds, with isolation periods ranging from 27 to 426 consecutive days (¯x = 165 ± 124 days). Data analysis followed Gadamer’s hermeneutic circle …

Helpful Autism School-Based Services: Perspectives From The People That Received Services, Michael Angelo Grizzaffi

Dissertations and Theses

Transitioning high school students with autism, primarily with a level 1 diagnosis, from high school to independence in young adulthood has evidence-based practices. However, preferences of the students who are receiving services had not been considered before. This study reviews the thoughts of what prior high school students find helpful in the services they receive. Choosing individualized evidence-based practices is ideal for students. Prior high school students' experiences demonstrate the desire for more transition skills teaching. Leading special educators in the skills of some evidence-based practices is required for the individualization of these practices the students need to occur. Leading …

Large Language Model Communication And Data Transfer Across A Simulated Telephone Line, Jared Reyes

Dissertations and Theses

This thesis presents a proof-of-concept communication system in which two local large language model endpoints communicate across a simulated analog telephone line using legacy USB modems. The project combines modem voice mode, modem data mode, local speech processing, and structured machine messaging into a single staged session. During the voice phase, one endpoint places a call, the other answers, speech generated by a locally hosted LLaMA-family model is synthesized with Piper, transmitted through the modem voice path, captured on the remote side, and transcribed with Faster-Whisper to drive the next response. After the voice exchange, the system transitions to a …

The Rhetoric And Memory Of Kumeprɛko, Benedicta Harford

Dissertations and Theses

This thesis examines the rhetoric of Kume Prɛko and asks what its major rhetorical appeals were both during 1994 and afterwards. First, I analyze major images and a speech from the protest and identify how it framed the VAT tax as an embodied, urgent issue for all citizens to resist. Then, I consider how Akufo-Addo silenced this "vernacular" memory in favor of his "official" narrative, drawing off the work of John Bodnar. Ultimately, this thesis shows how difficult it is for those in power to remember grassroots dissent in all their complexity but also how hard it is to completely …

The Role Of Bacteriophage In The Rgg1-Mediated Virulence Control Of Streptococcus Pyogenes, Yuan Tian

Dissertations and Theses

In Streptococcus pyogenes, bacteriophages and other horizontally transmissible elements (HTEs) comprise approximately 10% of the genome, and each clinical isolate carries a unique combination of these elements, contributing to genetic diversity, virulence, antibiotic resistance, and immune evasion. Previously, our laboratory identified binding sites of the transcriptional regulator Rgg1 in the clinical isolate NZ131 and demonstrated that Rgg1 influences genome-wide gene expression, including bacteriophage genes. In the clinical isolate SF370, the prophage SpyCIM1, positioned in the chromosome between the mutL and mutS genes, controls DNA mismatch repair through excision and reintegration into the chromosome. In the integrated form, the prophage displaces …

Stiffening Of Soft Silicone Upon Deep Uv Treatment As Characterized Using Nanoindentation, Amanda Wilder, Zaria Booth, Caden Obermeyer, Saika Sharmin, Venkat Maruthamuthu

Mechanical & Aerospace Engineering Faculty Publications

Silicones are elastomers that have a wide variety of uses, including biomedical applications such as the coating of biomedical devices and as implants. Soft silicones with mechanical properties similar to those of biological tissues have particularly gained use as substrates for cell culture in mechanobiology studies. In this context, it would be desirable to be able to alter their surface mechanical properties with a relatively simple physical treatment. While deep ultraviolet (deep UV) or ultraviolet C (UV-C) treatment has been previously used as a surface treatment method for stiffer silicones formulations, the effect of this treatment on soft silicones relevant …

Obituary For The Birth Certificate, Malinda L. Seymore

Faculty Scholarship

Have birth certificates outlived their usefulness? Birth certificates establish an individual’s name, identity, age, race, sex and gender, parental authority, and citizenship. In addition, the information collected at the time of birth and reflected on a long-form birth certificate provides data for public health policy, population statistics, internal migration, government planning, and resource allocation. Birth certificates are also the all-access pass to American life, necessary for many functions of modern life: registering a child in school, signing a child up for soccer, getting a driver’s license and passport, enlisting in the military, and applying for government benefits. All of this, …

Health Truth To Power: Professional Collaboration To Bolster Trust Against Misinformation, William M. Sage, Keegan D. Warren

Faculty Scholarship

This Article is about health, leaving aside more general challenges to shared civic information today. The Article begins by surveying the principal challenges for health information in post-pandemic, arguably post-truth America, and then describes briefly the sources and limits of medical professional authority. Noting the double-edged sword of free speech guarantees under the U.S. Constitution, the Article continues by commenting on speaking truth to government, to industry, and to the crowd. Next, the Article considers the physicians’ role in speaking truth to power from the perspective of standard medical professional ethics and identity, comparing it to that of lawyers. Finally, …

Does It Matter What People Lie About?, Stefanie Jung, Peter Krebs, Monika Leszczynska

Faculty Scholarship

We investigate whether people’s moral judgments of lies in pre-contractual negotiations differ from their views on whether such lies should give the deceived party a legal right to rescind the contract, and whether these judgments depend on the content of the lie. In a vignette study with 832 German students and 885 participants from Germany, Italy, and the United States, respondents evaluated a range of common negotiation lies. Across samples, participants were generally more likely to deem a lie immoral than to believe it should justify rescission, but the size of this gap varied depending on the lie’s subject. Lies …

Comparison Of Groundwater Ownership Regimes In Ten Jurisdictions Across Five Continents, Gabriel Eckstein, Theo Buchler, Caleb Cook, Heping Dang, Robyn Stein, Stefano Burchi, Gabriela Cuadrado Quesada, Juan Pablo Galeano, Eric Garner, Amy Hardberger, Imad Antoine Ibrahim, Oudi Kgomongwe

Faculty Scholarship

The regulation of groundwater remains underdeveloped globally and often lags behind the domestic governance of surface water. As a result, groundwater is often subject to unfettered extraction, uses, and contamination. A clear understanding of ownership is central to the success of domestic regulations. However, the types of ownership regime in place in nations around the world are poorly documented in the academic literature. This study addresses that gap through a comparative analysis of domestic groundwater ownership regimes across ten jurisdictions in nine countries spanning five continents. It identifies three dominant models of groundwater ownership: private ownership, public ownership, and non-ownership …