Digital Commons Network^™

The Stl Battlehawks Roster Outlook, Justin Powell

Lindenlink (2012- )

No abstract provided.

Advances In Targeting Her2 Across Cancer Subtypes: A Pan-Tumor Approach, Taiwo Adesoye, Ecaterina E Dumbrava, Kanwal P S Raghav, Aysegul A Sahin, Hui Chen, Milind M Javle, Omar Alhalabi, Xiuning Le, Vicente Valero, Paula R Pohlmann, Funda Meric-Bernstam

Faculty, Staff and Student Publications

Human epidermal growth factor receptor 2 (HER2) is an established therapeutic target in multiple solid tumors, particularly breast and gastric cancers. Significant advancements have been made in the development of HER2-targeted therapies, including monoclonal antibodies, tyrosine kinase inhibitors, antibody-drug conjugates (ADC), and novel bispecific antibodies. These agents have revolutionized the treatment landscape for HER2-positive metastatic cancers, resulting in improved progression-free and overall survival, and quality of life for patients. Beyond breast and gastric cancers, HER2 expression/amplification has been observed in other solid tumors, such as colorectal, lung, bladder, ovarian, and biliary tract cancers, offering new opportunities for personalized therapy in …

Aberrant Cd25 And Increased Cd123 Expression Are Common In Acute Myeloid Leukemia With Kmt2a Partial Tandem Duplication And Are Associated With Flt3 Internal Tandem Duplication, Qing Wei, Guilin Tang, Shaoying Li, Sa A Wang, Pei Lin, Sanam Loghavi, L Jeffrey Medeiros, Jie Xu

Faculty, Staff and Student Publications

Background: KMT2A partial tandem duplication (PTD) occurs in approximately 5-10% of acute myeloid leukemia (AML) cases and is associated with poor prognosis. While its cytogenetic and molecular features are well described, the immunophenotypic characteristics of AML with KMT2A-PTD remain incompletely defined.

Methods: We identified 47 cases of AML with KMT2A-PTD by optical genome mapping. All cases underwent flow cytometric immunophenotypic analysis and next-generation sequencing using an 81-gene panel.

Results: The cohort included 32 men and 15 women with a median age of 67 years (range, 19-87). Thirty-eight cases were de novo AML, and nine were secondary to myelodysplastic …

Emt-Induced Stem Cell And Mesenchymal Programs Can Be Decoupled Via Cell Division And Esrp1-Dependent Mechanisms, Petra Den Hollander, Maria Castaneda, Suhas V Vasaikar, Joanna Joyce Maddela, Claire Gould, Robiya Joseph, Abhijeet P Deshmukh, Alvina Zia, Shruti Shah, Tieling Zhou, Geraldine Raja, Paul Allegakoen, Nick A Kuburich, Mika Pietila, Chunxiao Fu, Jeffrey Chang, Chad J Creighton, William F Symmans, Rama Soundararajan, Sendurai A Mani

Faculty, Staff and Student Publications

Epithelial-to-mesenchymal transition (EMT) is known to induce both stemness and mesenchymal properties, and our findings reveal that these two programs can be uncoupled. During EMT, epithelial cells transition from symmetric divisions producing differentiated daughter cells to self-renewing daughter cells. When we block cell division and induce EMT, cells gain mesenchymal properties but not stemness, suggesting the importance of cell division for gaining stemness. We identified ESRP1 as a key regulator of EMT-driven stemness, which get downregulated during EMT in a cell division-dependent manner. Overexpression of ESRP1 prevents the gain of stemness without affecting the mesenchymal program. Only the stemness and …

Glutamatergic Projection Neurons In The Basal Forebrain Underlie Learned Olfactory Associational Valence Assignments, Pey-Shyuan Chin, Zhuokun Ding, Mikhail Kochukov, Snigdha Srivastava, Elizabeth H Moss, Benjamin R Arenkiel

Faculty, Staff and Student Publications

Sensory perception is shaped by experience, giving stimuli behavioral significance. Basal forebrain (BF) cholinergic neurons in mice, which are crucial for arousal and motivation, also regulate sensory processing. Within BF nuclei, glutamatergic (vGlut2BF) neurons receive cholinergic input and modulate behaviors, but their roles in encoding sensory significance remain unclear. Using in vivo calcium imaging, we found that vGlut2BF neurons initially poorly encoded odor identity. However, their response to conditioned odors increased following associative learning, and their population activity more distinctly encoded paired stimuli, reflecting emergent value representation. Furthermore, pairing stimulation or inhibition of vGlut2BF neurons with specific odors altered odor …

Role Of The Etv5/P38 Signaling Axis In Aggressive Thyroid Cancer Cells, Jerry H Houl, Rozita Bagheri-Yarmand, Muthusamy Kunnimalaiyaan, Paola Miranda Mendez, Joseph L Kidd, Andrea Ruiz-Jurado, Ying C Henderson, Nikhil S Chari, Aatish Thennavan, Reid T Powell, Clifford C Stephan, Xiao Zhao, Anastasios Maniakas, Roza Nurieva, Naifa L Busaidy, Maria E Cabanillas, Ramona Dadu, Mark Zafereo, Jennifer R Wang, Stephen Y Lai, Marie-Claude Hofmann

Faculty, Staff and Student Publications

Patients with poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) face a much poorer prognosis than those with differentiated thyroid cancers. Around 25% of PDTCs and 35% of ATCs carry the BRAFV600E mutation, which constitutively activates the MAPK pathway, a key driver of cell growth. Although combining BRAF and MEK inhibitors can shrink tumors, resistance often develops. The exact cause of this resistance remains unclear. We previously found that in PDTC and ATC cells, the BRAFV600E mutation is strongly linked to the expression of ETV5, a transcription factor downstream of the MAPK pathway. In the current study, we …

Integrative Spatial Multi-Omics Reveal Niche-Specific Inflammatory Signaling And Differentiation Hierarchies In Aml, Enes Dasdemir, Ivo Veletic, Christopher P Ly, Andres E Quesada, Christopher D Pacheco, Pamella Borges, Sonali Jindal, Zhiqiang Wang, Alexander Lazar, Khalida M Wani, Dinler A Antunes, Patrick K Reville, Preethi H Gunaratne, Robert J Tower, Padmanee Sharma, Hussein A Abbas

Faculty, Staff and Student Publications

Acute myeloid leukemia (AML) is a clonal disorder characterized by immature blasts and arrested differentiation that primarily affects the bone marrow (BM) and occasionally presents as extramedullary (EM) disease. EM manifestations highlight AML's adaptability to distinct microenvironments, which we examined using spatial analyses of medullary and EM tissues. We describe a workflow for Visium-based spatial transcriptomics in medullary and EM AML, revealing insights into cell-cell communication and the spatial organization of AML hierarchies. In BM, monocytes and granulocyte-monocyte progenitors colocalized with leukemic populations, sharing molecular signatures with those in EM sample. CXCL12-CXCR4-mediated communication correlated with PI3K/AKT/mTOR signaling in inflammatory niches.

Loss Of Payload Sensitivity And Other Mechanisms Of Resistance To T-Dxd In Her2-Mutant Nsclc: Implications For Subsequent Responsiveness To Her2 Tkis, Monique B Nilsson, Xiuning Le, Alissa Poteete, Xiaoxing Yu, Junqin He, Yuji Shibata, Cesar Moran, Ash A Alizadeh, Maximilian Diehn, Heather Wakelee, Diego Almanza, Scott Soltys, Takeshi Sugio, Jurik Mutter, Xiaoman Kang, Rui Wang, Soyeong Jun, Mohammad Shahrokh Esfahani, Hai Tran, Yuanxin Xi, Lingzhi Hong, Xiaofang Huo, Ashwani Kumar, Xiaoyang Ren, Kei Oguchi, Kazuhisa Minamiguchi, Caroline M Weipert, Jing Wang, Ralf Kittler, John V Heymach

Faculty, Staff and Student Publications

Introduction: Effective therapies are needed for patients with NSCLC with HER2-mutant tumors who progress on the HER2 antibody-drug conjugate trastuzumab deruxtecan (T-DXd), a standard-of-care treatment. A greater understanding of mechanisms mediating acquired T-DXd resistance and whether these tumors could benefit from HER2 tyrosine kinase inhibitors (TKIs) is needed.

Methods: Using preclinical models of acquired T-DXd resistance, LentiMutate scanning mutagenesis, and clinical analyses, we investigated mechanisms mediating acquired resistance to T-DXd and assessed the impact of each of these resistance mechanisms on cross-resistance to alternative HER2-targeting approaches.

Results: We determined that acquired resistance to T-DXd could occur through multiple mechanisms including …

Differential Blood-Brain Barrier Permeability Driven By Asymmetric Hypoperfusion In A Vascular Dementia Model, Mengjun Dai, Kuizhi Qu, Ying Jiang, Song Gao, Yan-Ning Rui, Zhen Xu

Faculty, Staff and Student Publications

Introduction: Blood-brain barrier (BBB) dysfunction has been associated with vascular dementia (VaD). However, the underlying mechanisms causing BBB dysfunction remain unclear, especially regarding cerebral hypoperfusion. This study aimed to investigate the effects of asymmetric hypoperfusion on BBB permeability using a mouse model of VaD.

Methods: Asymmetric bilateral common carotid artery stenosis (ACAS) was induced using ligature rings. BBB integrity was assessed on 3 days post-surgery using Evans blue, IgG, and albumin extravasation. A modified tissue processing protocol optimized endogenous marker detection. Regional and sex-based differences in BBB permeability were analyzed.

Results: Increased BBB permeability was observed in both corpus callosum …

Probability Cueing In Large-Scale Environmental Search: The Role Of Landmark Cues In Statistical Learning, Shaun Dordoy, Rory Baxter, Alastair Smith

School of Psychology

Efficient environmental search is an important and adaptive everyday skill. A particular feature of theoretical interest is whether large-scale search is informed by the spatial statistics of the environment - probability cueing is a robust effect in two-dimensional visual search tasks, but studies of large-scale search have generated equivocal findings. Here, we examined whether sensitivity to a statistical cue specified within an allocentric reference frame is modulated by the presence and location of environmental landmarks. Participants explored fully immersive virtual environments, wherein they were presented with an array of locations (columns) and required to search them for a hidden target …

Rnai-Based Screen For Pigmentation In Drosophila Melanogaster Reveals Regulators Of Brain Dopamine And Sleep, Harim Delgado-Seo, Yoko Fujita, Kyla Wilwayco, Elaine S Seto, Amita Sehgal, Shinya Yamamoto

Faculty, Staff and Students Publications

The dopaminergic system has a large role in behavior and neurological disease, and understanding dopamine level regulation in vivo is critical. To identify dopamine regulators, we utilized Drosophila melanogaster cuticle pigmentation, where dopamine is a precursor to melanin. We measured dopamine from known pigmentation mutants (e.g., tan, ebony, black) and performed an RNAi-based screen to identify additional regulators. We found 153 hits, enriched for developmental signaling pathways and mitochondria-associated proteins. From 35 prioritized candidates, 11 affected head dopamine levels. Effects on brain dopamine were mild, even knocking down the rate-limiting synthesis enzyme Tyrosine hydroxylase (TH), suggesting …

Attitudes Toward Patients' Safety Among Healthcare Professionals In The United Arab Emirates: A Cross-Sectional Study, Moien Khan, Amiri Sohrab, Iffat Elbarazi, Mohammed Salaheldin Elsayed, Reem Al Falasi, Debasish Kar

Peninsula Medical School

This research aims to investigate healthcare professionals’ (HCPs) attitudes towards patient safety and to explore the role ofvarious work-related factors that could be the barriers to safety-events reporting to modify these attitudes. A cross-sectionalsurvey was conducted, involving 629 HCPs who are working across health care sectors in the United Arab Emirates. HCPs in theUnited Arab Emirates, comprising 71.5% women and 27.8% men, displayed a generally positive attitude towards patient safety(mean score = 3.91). Sub-comparisons indicated high scores for team functioning (4.58 ± 0.62) and low scores for professionalincompetence as an error cause (2.86 ± 0.50). Common barriers to reporting safety …

The Itrail Making Test (Itmt): An Evaluation Of Novel Testing Paradigms, Hidden Indices Of Measurement, And Diagnostic Accuracy In Parkinson’S Disease, Donnchadh Murphy, Jonathan Scott, Craig Newman, Rupert Noad

Peninsula Medical School

Introduction: The Trail Making Test (TMT) is an important test when assessing for cognitive difficulties in people with Parkinson’s Disease (PD). However, the pencil-and-paper format can be susceptible to administration and scoring errors and may disproportionately reflect motor impairments rather than cognitive performance. The current study sought to evaluate the reliability and diagnostic accuracy of two novel computerized versions of the TMT: iTMT-Tap and iTMT-Drag. Method: This study used a quasi-experimental diagnostic accuracy design, and included 34 healthy controls, 28 people with Parkinson’s disease with normal cognition (PD-NC), and 31 people with Parkinson’s disease mild cognitive impairment (PD-MCI). Participants were …

Leadless Versus Transvenous Dual-Chamber Pacemakers: Real-World Evidence From Aveir Dr Coverage With Evidence Development Study., Monica Lo, Anish K Amin, Marcin Kowalski, Anne Kroman, Dilip Mathew, Valay Parikh, Stanislav Weiner, Jennifer M Joseph, Leonard Ganz, Mohammed Mortada

Heart and Vascular Articles

BACKGROUND: AVEIR DR, an industry-first dual-chamber leadless pacemaker (LP), provides continuous atrioventricular synchrony through implant-to-implant (i2i) communication between atrial and ventricular LP devices. It is important to evaluate the early real-world comparative safety of AVEIR DR LP.

OBJECTIVE: To compare complications and mortality between AVEIR DR LP and dual-chamber transvenous pacemakers (TP).

METHODS: De novo LP and TP patients were identified in Medicare Fee-for-Service claims (October 2023 and December 2024). Outcomes were 30-day and 6-month complications, reinterventions, heart failure hospitalizations, and all-cause mortality. Comparisons were adjusted for demographics, comorbidities, and hospital encounter characteristics.

RESULTS: Compared to TP (N = 77 …

Considerations When Venturing Into Community Engagement With Those Who Struggle To Access Advice Or Care, Ruth Potterton, Abigail Nelder, Karen Burn

Peninsula Dental School

No abstract provided.

Selective Deletion Of Slc2a1 From The Rpe Reveals That Rods But Not Cones Depend On Glucose Transport Across The Outer Blood-Retinal Barrier, Lauren L. Daniele, John Y.S. Han, Minzhong Yu, Ravi A. Sangani, Craig D. Beight, Cyrus Rostami, Philip D. Kiser, Neal S. Peachy, Nancy J. Philp

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

GLUT1 facilitates a continuous flow of glucose across the inner and outer blood-retinal barriers (BRBs) to support vision. To understand the extent to which photoreceptors rely on glucose transport across the outer BRB, we generated a tamoxifen-inducible conditional knockout of Slc2a1 in the retinal pigment epithelium (RPE) (RPE-iΔGlut1). In the RPE-iΔGlut1 mice, rod photoreceptors exhibited impaired outer segment renewal and decreased the expression of proteins involved in phototransduction and ciliary transport. Proteins regulating the retinal stress response increased. Cone photoreceptors were functional and viable 15 months post-tamoxifen treatment in the RPE-iΔGlut1 mice, while 70% of the rods died. …

Open Access After Graduation, Wendy Walker, Megan Stark, Kate Zoellner, Karli Cotton

Navigating the Future Together: Student Success Symposium

Academic libraries have, for too long, built relationships with students around a single dimension: temporary access to paywalled scholarly materials. We believe this dimension is too narrow and short-term to honor the complexity of our students’ future goals and their lives beyond graduation.

Open Access (OA) scholarship helps us reimagine relationships with our students far longer than their institutional login credentials, and to empower them as lifelong information-literate individuals. Freely available to readers, OA research extends the benefits of scholarly knowledge beyond the academy and removes economic barriers to accessing information. OA invites us to engage the multiple, evolving, and …

Student Success And Well-Being: Library Resources For The Whole Student, Kimberly Shotick

Navigating the Future Together: Student Success Symposium

This poster will outline the rationale and methods for developing and maximizing library collections designed to foster student success. While academic library collections generally support the academic curriculum, students’ needs extend far beyond coursework. At Northern Illinois University, the Student Success and Well-being Collection was created to foster positive emotions, promote self-care, and enhance academic achievement. Alongside practical titles on topics such as time management, the collection also features identity-based works that strengthen belonging for diverse student groups. Usage data shows that the collection circulates at significantly higher rates than the general collection, demonstrating its relevancy and potential impact. The …

Fostering Neurodivergent Student Success: A Participatory Action Research Approach To Inclusive Library Instruction, Mercedes Rutherford-Patten, Luna Nombrano Larsen

Navigating the Future Together: Student Success Symposium

Neurodivergent students represent 20–30% of college populations, yet many face barriers to academic success, including inaccessible instruction, lack of tailored support, and stigma. Academic libraries, as key sites of student learning and belonging, have the potential to reduce these barriers and foster more equitable outcomes. This poster presents Fostering Neurodivergent Student Success: Using a Participatory Action Research (PAR) Approach to Engage Students in the Development of More Inclusive, Accessible, and Engaging Library Instruction and Services, a grant-funded participatory action research project at California Polytechnic State University, San Luis Obispo. This research approach engages neurodivergent students as co-researchers and co-designers in …

The Soar Approach: Contributing To Library's Role In Student Success Initiatives From Non-Administrative Roles, Lilly Ramin

Navigating the Future Together: Student Success Symposium

This poster discusses the SOAR approach for student success initiative feedback from outside of library administrative roles. Using common documentation and efforts for strategic planning, the goal is transferable tips for across institutions. SOAR stands for: Strategy (Strategic Planning), Outreach, Assessment and Reporting. The process may be iterative and cyclical.

Law & Morals: Creating A Tactile Map Of An Inaccessible Library, Kristin Peace, Ben Mendez

Navigating the Future Together: Student Success Symposium

Short Description:

Under the ADA, colleges are required to make all programs equally accessible to all students. In the Summer of 2025, the Technology & Makerspace Librarian and Social Sciences Librarian at Occidental College set out to create a tactile map of their library. This is their story.

Abstract:

Although legally required under the American Disabilities Act (1990), the Mary Norton Clapp Library at Occidental College lacks many basic accessibility accommodations. Not surprisingly, few students, faculty or staff with disabilities choose to become part of the Occidental College community. This past summer, the Technology & Makerspace Librarian and Social Sciences …

Playing Across Cultures: Building Community Through International Games Month At Southern Miss Libraries, Tisha M. Zelner, Courtney Kruzan

Navigating the Future Together: Student Success Symposium

Embracing diverse voices is part of the vision of the University of Southern Mississippi (USM) Libraries, which also includes a value statement to “embrace diversity by creating a welcoming environment and providing resources representative of the diverse university populations.” The library's strategic values also include collaboration, engagement, and outreach. The library created International Games Month (IGM) programming in 2023 in support of the library’s strategic goals and invited collaboration with the university’s International Student and Scholar Services as well as individual student organizations. The library hosted events where international students coached attendees through games from their home countries. Student representatives …

Disinformation Detox: Media Literacy As A Tool For Student Empowerment, Chereeka Garner

Navigating the Future Together: Student Success Symposium

Background

In an era of deepfakes, algorithmic manipulation, and viral misinformation, students face increasing challenges in discerning credible information. Media literacy has become a critical skill for academic success and informed citizenship.

Module Overview

Media Literacy Essentials is a newly launched pilot module designed to help students "detox" from disinformation by equipping them with foundational skills in evaluating sources, identifying bias, and understanding media production. The module is part of a first-year experience course and encourages active engagement with real-world media.

Preliminary Observations

Now in its first semester, the module has shown encouraging signs of student engagement and curiosity. While …

Connecting Mental Health, Retention, And Graduation: The Critical Role Of Library Staff And Student Employees In A Small Academic Library, Amy Dye-Reeves

Navigating the Future Together: Student Success Symposium

This poster highlights how a small academic library and its staff support student employee mental health, boosting retention and graduation. Through targeted strategies and a caring environment, the Library of Architecture, Construction, and Design proves small libraries make a big impact on student success.

Developing A Student Success And Engagement Framework For Wvu Libraries, Kelly Diamond, Amy Melnyk

Navigating the Future Together: Student Success Symposium

Defining student success in higher education is both complex and daunting, as the term overlaps with persistence, belonging, achievement, and wellbeing. The phrase itself is often unwieldy, making it difficult for academic libraries to determine how their work fits into broader institutional efforts. To address this challenge, the Student Success and Instruction Unit at West Virginia University Libraries sought a clear framework to define Student Success to guide planning, clarify scope, strengthen collaborations, and make library contributions visible and high impact.

The unit developed The Student Success and Engagement Framework (drawing on Bond & Bedenlier, 2019; Zhu et al., 2025) …

Using Kolb’S Experiential Learning Framework To Create Student-Centered Library Instruction, Kari Darby

Navigating the Future Together: Student Success Symposium

Description: Advocates of student-centered instruction advise instructors to act as facilitators to active learning. I will discuss how I used a modified version Kolb’s Experiential Learning Framework to develop workshops that guide students to reflect, explore, and apply their knowledge, leaving the instructor in a guiding role.

Abstract: While the CSULB Library has library instruction integrated in many courses, students receive varying levels of library instruction based on their individual paths. To address these gaps, I developed a series of workshops that break down the steps of academic research and provide a session for each step. The titles of the …

Universal Design For Learning: Simple Tips For More Inclusive Instruction, Nicole Burchfield

Navigating the Future Together: Student Success Symposium

Short Description:

The Universal Design for Learning guidelines are a roadmap to an inclusive classroom. They help you build lessons that engage students, increase knowledge retention, and help you create a sense of belonging. I will present many simple steps you can take to implement the UDL guidelines in your instruction today!

Abstract:

The Universal Design for Learning guidelines are a tried-and-true roadmap to an inclusive classroom. Inclusivity in the classroom is important for student learning from so many perspectives for ALL learners of ALL abilities. UDL not only helps to create equity and engagement in the classroom it’s also …

Student Success And Library-Provided E-Textbooks: Initial Results From A Student Survey, Marion Archer

Navigating the Future Together: Student Success Symposium

The University of Wisconsin-Milwaukee Libraries have been running a program for the past two years to offer unlimited-user e-texts of required course materials to students in classes where those texts are available for us to purchase with an institutional license. This program is called eCATs, an acronym for e-Course Assigned Texts. A survey was sent to students in courses where eCATs were available to assess the impact of the availability of the texts on student success as well as understand student practices in relation to textbook acquisition and usage. Some surprising results emerged regarding student definitions of success and the …

A Makerspace For Grieving Students: An Exploration Of Memory And Making For Bereaved Students At The University Of Georgia, Lindsey H. Allison

Navigating the Future Together: Student Success Symposium

With origins in grief counseling, conversations regarding continuing bonds have supported and encouraged a connection between the living and the dead as a means for processing loss. Some bereaved individuals turn to physical mediums, such as archiving the belongings of the deceased or creating original artwork, to remain connected to their loved ones and find peace in their wake. As student success librarians, we aim to view students holistically, acknowledging aspects of their identities that lay beyond the scope of their academic endeavors, including aspects pertaining to grief and loneliness. In order to help students develop and succeed at university, …

We Wrote The Book On That: Professional Development For Accessible Library Teaching, Katie Harding, Anna Flak

Navigating the Future Together: Student Success Symposium

Incorporating principles of accessibility into library teaching practices, online learning objects, and library services is critical to fostering student belonging and student success. However, accessibility guidelines specific to academic library work are limited. In this lightning talk, we’ll describe how we embarked on a library initiative to develop an openly licensed book containing practical guidance for our library staff about how to incorporate accessibility in the many ways we work with students. This collaborative project engaged library workers from across departments in learning and writing about accessibility in libraries. We will describe the process of assembling a team, the writing …