Digital Commons Network^™

Evaluation Of Poly-Ε-Caprolactone/Graphene Oxide Three-Dimensional Porous Scaffolds For Potential Application In Alveolar Bone Repair, Yung-Kang Shen, Huei-Yu Huang, Jowy Tani, Hsuan Chen, Silvia Anitasari, Hendrik Budi, Wei-Chun Lin

Journal of Dental Sciences

Background/purpose Alveolar bone reconstruction or regeneration demands the interim porous scaffold. It possesses adequate mechanical properties to enable it to withstand injured bones. These scaffolds are used to regulate the cell growth that migrate from surrounding tissue or are implanted within porous scaffold. This study is devoted to the manufacturing of 3D porous scaffolds and application on repair and regeneration of alveolar bone. Materials and methods Graphene oxide (GO) was mixed with poly-ε-caprolactone (PCL) material to fabricate 3D porous scaffolds by a solvent-casting/particulate-leaching method. The effects of various concentrations of GO (0.05, 0.1, 0.5, 1, and 2 wt.%) in PCL/GO …

Evaluating Thymol Vapor For Biofilm Removal And Biocompatibility In Curved Root Canal Models In Vitro, Maria Paulene Dee Manuel, Yin-Hwa Shih, Shih-Min Hsia, Tong-Hong Wang, Yu-Hsin Tseng, Ming-Gene Tu, Tzong-Ming Shieh

Journal of Dental Sciences

Background/purpose Conventional irrigants such as chlorhexidine and sodium hypochlorite have strong antimicrobial properties but high cytotoxicity, limiting their use in regenerative endodontics. We hypothesized that thymol vapor could provide effective antibacterial activity with lower cytotoxicity. Materials and methods The antimicrobial activity of thymol in both liquid and vapor phases was tested against Enterococcus faecalis, Streptococcus mutans, and Aggregatibacter actinomycetemcomitans using a resin block model simulating curved root canals. The effect of thymol vapor, alone or with mechanical instrumentation, was tested on early-stage biofilms removal. Cytotoxicity was assessed using MTT assays in L-929 fibroblasts and MG-63 osteoblast-like cells, and pro-inflammatory cytokine …

Impact Of Orthodontic Treatment On Masticatory Muscle Electromyographic Patterns In Patients With Anterior Crossbite, Yi-Mien Cheng, Yueh-Ling Hsieh, Yu-Hsiang Chang, Yuan-Hou Chen, Jian-Hong Yu

Journal of Dental Sciences

Background/purpose Anterior crossbite affects facial aesthetics and may cause temporomandibular joint disorders and masticatory muscle dysfunction. Prolonged abnormal bite positioning may impact muscle activity and affect treatment stability. Although orthodontic therapy aims to realign teeth and correct bite relationships, the neuromuscular adaptations following treatment remain unclear. This study aims to investigate the changes in masticatory muscle activity before and after orthodontic treatment in patients with anterior crossbite using surface electromyography (sEMG). Materials and methods 41 participants were recruited and divided into 3 groups: normal occlusion (n = 18), anterior crossbite without treatment (control, n = 6), and anterior crossbite with …

Biocompatibility And Cytotoxic Effects Of Myofunctional Appliance Materials On Human Periodontal Ligament Fibroblasts, Tsui-Hsien Huang, Tso-Hsun Yang, Chuan-Yi Kao, Chun-Te Ho, Peerapong Santiwong, Chia-Tze Kao

Journal of Dental Sciences

Background/purpose Prefabricated myofunctional devices are widely used in children's dentistry and early orthodontics. This study investigated the effects of materials used in myofunctional appliances on the viability of human periodontal ligament fibroblasts (HPLFs), inflammatory responses, and bone remodeling under simulated oral conditions. The focus was on biocompatibility and cytotoxicity to ensure safety in clinical applications. Materials and methods Four materials—EF Line (EF), ProOrtho (PO), Myobrace (MB), and Invisalign (IV)—were tested under conditions with and without artificial saliva (AS). HPLFs were cultured and exposed to eluates from these materials for 24, 48, and 72 h. Cell viability was measured using the …

Improvement In Oral Hygiene Among Bedridden Patients Following Domiciliary Dental Care: A Retrospective Study, Min Yee Ng, Chuan-Hang Yu

Journal of Dental Sciences

Background/purpose Domiciliary dental care (DDC) offers dental services in the comfort of a patient's home, typically for bed-bound patients. Poor oral hygiene in this group has been associated with pneumonia. Although DDC reduces the risk of pneumonia, its impact on oral hygiene has not been explored yet. Therefore, this retrospective study aimed to investigate the effectiveness of DDC in improving oral health in bedridden patients. Materials and methods We retrospectively reviewed individuals who received dental services and evaluated their oral hygiene status using the plaque index (PI). Demographic data (age, sex, cause of bedridden state) and oral findings (DMFT, number …

Laser-Modified Titanium Surfaces Induce Sex-Dimorphic Secretion Of Angiogenic Factors By Gingiva-Derived Mesenchymal Stromal Cells, Ting-Han Chang, Hsin-Han Hou, Yi-Shing Shieh, Her-Hsiung Huang, Da-Yo Yuh

Journal of Dental Sciences

Background/purpose Dental implants have been applied to restore missing dentition for more than fifty years. However, whether different surface modification on implant provide topographical cues that alter sex-specific effect on peri-implant angiogenesis remains unclear. This study aimed to investigate whether titanium surface modifications influence sex-specific chromatin accessibility, gene expression, and angiogenesis-related functions in human gingiva-derived mesenchymal stromal cells (GMSCs). Materials and methods We collected health gingival tissues from sixteen subjects (eight females and eight males) and isolated primary GMSCs. The primary GMSCs were cultured on three types of titanium surfaces: machined, lasered, and SLA (sand-blasted, large-grit, acid-etched). Chromatin accessibility and …

Successful Prevention Of Medication-Related Osteonecrosis Of The Jaw After Dental Extractions By Socket Preservation With Alloplast Plus Tetracycline In Patients Taking Antiresorptive Drugs, Liang-Ho Lin, Chun-Hsiang Wang, Shin-Yu Lu

Journal of Dental Sciences

Background/purpose Medication-related osteonecrosis of the jaw (MRONJ) is a serious side effect of antiresorptive, antiangiogenic or targeted agents, and usually occurs after dental extraction. The etiopathogenesis of MRONJ is multifactorial and not fully understood. MRONJ remains difficult to treat. Precluding MRONJ occurrence is therefore essential. We offer our experiences and treatment strategies regarding the successful prevention of MRONJ after tooth extractions in patients taking antiresorptive drugs (ARDs). Materials and methods Under ARDs cessation of at least 3 months before and after oral surgery, 106 consecutive patients who underwent 249 dental extractions on 137 occasions were examined according to complete follow-up …

Adjuvant Metronomic Tegafur-Uracil Is Associated With Poorer Outcomes And Unfavorable Histopathologic Progression In Oral Squamous Cell Carcinomas, Kai-Feng Hung, Yi-Ping Wang, Yi-Chen Sun, Zhi-Qian Lin, Cheng-Hsien Wu, Peter Chang, Julia Chang

Journal of Dental Sciences

Background/purpose Tegafur-uracil (UFUR) is widely prescribed as metronomic adjuvant chemotherapy for oral squamous cell carcinoma (OSCC) in East Asia, though its long-term benefit remains unclear. This study aimed to evaluate the oncologic and pathological impact of adjuvant UFUR in a large real-world OSCC cohort spanning three decades. Materials and methods This retrospective, single-institution cohort included 2048 patients with histopathologically confirmed OSCC treated at a tertiary medical center in Taiwan (1990–2020). All underwent curative-intent surgery with or without postoperative radiotherapy or concurrent chemoradiotherapy (CCRT). Among them, 878 patients received adjuvant metronomic UFUR for ≥12 months. Survival outcomes were analyzed using Kaplan–Meier …

Impact Of Bone Surface Inclination On The Precision Of Static Fully Guided Implant Surgery: A Quantitative Analysis, Shiu-Fong Ou, Szu-Yu Huang, Chia-Yuan Hu, Tsung-Chieh Yang, Tong-Mei Wang

Journal of Dental Sciences

Background/purpose Although static fully guided systems improve the accuracy of implant placement, most studies have focused on flat bone surfaces, with limited exploration of the effects of sloped bone surface. In this study, we aimed to evaluate the effects of bone surface inclination on the accuracy of static fully guided implant surgery. Materials and methods Three 3D-printed maxillary models with a missing upper right lateral incisor were fabricated and each accommodated artificial bone blocks (Sawbones®). Bone blocks were grouped according to the buccal surface inclination (0°, 30°, and 60°; n = 10 per group). A static fully guided surgical system …

Apoptosis-Inducing Factor Mitochondria-Associated 2 (Aifm2) Promotes Tumor Progression And Predicts Poor Prognosis In Oral Squamous Cell Carcinoma, Chung-Hsien Chou, Kuo-Wei Chang, Wan-Wen Hung, Miao-An Wei, Chung-Ji Liu, Shu-Chun Lin

Journal of Dental Sciences

Background/purpose Head and neck squamous cell carcinoma (HNSCC), including oral squamous cell carcinoma (OSCC), remains a major malignancy with limited therapeutic efficacy. Apoptosis-inducing factor mitochondria-associated 2 (AIFM2), also known as ferroptosis suppressor protein 1, regulates ferroptosis and tumor progression. This study investigated the oncogenic function, clinical relevance, and regulation of AIFM2 in OSCC. Materials and methods Transcriptomic data from TCGA HNSCC and in-house OSCC RNA-Seq datasets were analyzed to assess AIFM2 expression and its association with clinicopathological features and outcomes. Functional assays evaluated the effects of AIFM2 knockdown or overexpression on OSCC cell proliferation, migration, invasion, and therapeutic response. MicroRNAs …

A Scientometric Study On Methylation Modification And Identification Of Related Genes In Oral Potentially Malignant Disorders And Oral Cancer, Lifen Yin, Xiaoliang Luo, Jian Liu, Wei Liu, Liying Gu

Journal of Dental Sciences

Background/purpose Accumulating evidence indicates that methylation modification alterations involve in the development and progression of oral cancer. The purpose of this study was to analyze the scientometric characteristics of methylation modification in oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC). Materials and methods All the papers on methylation research in OPMD/OSCC were comprehensively retrieved from the Scopus database with emphasis on the identification of methylation related genes. Results A total of 365 papers on methylation research in OPMD/OSCC were retrieved. The total citation count was 9998 and the h index was 53 for all the papers. The …

A Scientometric Study On Research Trends And Characteristics Of Randomized Controlled Trials In Orthodontics, Ning Wang, Yang Yu, Linjun Shi, Zhechen Zhang, Jianwei Song

Journal of Dental Sciences

Background/purpose In evidence-based approaches to orthodontic research, randomized controlled trials (RCTs) are recognized as the highest level of original evidence. The purpose of this study was to analyze the scientometric characteristics and research trends of RCTs in orthodontics, with emphasis on chronological comparison and regional characteristic of the keywords. Materials and methods All the reports on RCTs in orthodontics were comprehensively retrieved from the Scopus database. The years of publication were divided into before 2020 and Jan 2020–Jul 2025 in the analysis of research trends. Results There were 1343 reports on RCTs in orthodontics, with total citations of 27,314 and …

Systematic Evaluation Of Genetic Polymorphisms In Carcinogen Metabolizing Enzymes Associated With The Risk Of Oral Potentially Malignant Disorders Occurrence, Chao Lou, Yuhan Zhu, Linjun Shi, Wei Liu

Journal of Dental Sciences

Background/purpose Accumulated studies investigate the association of single-nucleotide polymorphisms (SNPs) in carcinogen metabolizing enzymes with oral potentially malignant disorders (OPMD) risk. However, these results were inconsistent and conflicting. The purpose of this pooled analysis was to systematically evaluate the associations of SNPs in 6 enzymes (CYP1A1, CYP2E1, GSTM1, GSTM3, GSTT1 and GSTP1) with risk of OPMD occurrence. Materials and methods A systematic evaluation was performed to identify all eligible case ndash;control studies on the association between SNPs in 6 enzymes and OPMD onset. Odds ratios (ORs) and 95 % confidence intervals (CIs) were pooled to estimate association strength. Results A …

Dental Caries Prevalence And Age-Related Patterns Among Populations Remaining In War-Affected Regions Of Ukraine, En-Tse Yen, Sung-Hsien Chiu, Wei-De Tsai, Gen-Min Lin, Kun-Zhe Tsai

Journal of Dental Sciences

Background/purpose The ongoing war in Ukraine has severely disrupted healthcare infrastructure, limiting access to preventive and restorative dental services. Most existing studies have focused on refugees abroad, while data from civilians who remained in conflict-affected regions are scarce. This study aimed to assess dental caries experience and age-related patterns among war-affected regions of Ukraine. Materials and methods A multinational medical team, in collaboration with local health institutions, delivered humanitarian medical and dental services in conflict-affected regions of Ukraine between September 17 and September 30, 2025. We retrospectively analyzed medical records from 230 civilians aged 12–85 years, assessing substance use, oral …

Long-Term Stability Of Implant Site-Switching Technique And Early Orthodontic Loading: A 16-Year Case Report, Tony Shing-Zeng Dung, Yuan-Yang Hsu, Cheng-Shan Li

Journal of Dental Sciences

No abstract provided.

Plunging Ranula With Extension To The Tongue Base, Satomi Sugiyama, Toshinori Iwai, Masaki Yoda, Kenji Mitsudo

Journal of Dental Sciences

No abstract provided.

Furcation-Involved Class Ii Subclass B Molar Treated By Er:Yag Laser-Assisted Comprehensive Periodontal Pocket Therapy (Er-Lcpt) Under A Microscope: A Case Report, Taichen Lin, Min Yee Ng, Yoichi Taniguchi, Akira Aoki

Journal of Dental Sciences

No abstract provided.

Bio-Obturation Of A Large Perforated Internal Root Resorption: A Case Report, Saeed Asgary

Journal of Dental Sciences

No abstract provided.

Exploring Existing Methods For Calculating Dental Arch Form And Curvature, Li-Tong Zheng, Sheng-Yang Lee, Yu-Chieh Lin, Wei-Chun Lin

Journal of Dental Sciences

No abstract provided.

Successful Non-Surgical Repair Of A Large Furcal Perforation Using Endodontic Biomaterials: A Case Report Of 30-Month Follow-Up, Saeed Asgary

Journal of Dental Sciences

No abstract provided.

Rethinking English Medium Instruction For Dental Education In Taiwan, Ching-Shuen Wang, Feng-Chou Cheng, Wei-Chun Lin, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.

Pleomorphic Adenoma With Extensive Squamous Metaplasia - A Case Report, Hung-Pin Lin, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.

The Exploration Of Dental Careers Among High School Girls In Taiwan During The Japanese Colonial Period, Feng-Chou Cheng, Ling-Hsia Wang, Shiang-Yao Liu, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.

The Dental Career Development Of Physicians During The Japanese Colonial Period In Taiwan: A Case Study Of Dr. Ying-Fang Chen, Feng-Chou Cheng, Ling-Hsia Wang, Shiang-Yao Liu, Chun-Pin Chiang

Journal of Dental Sciences

No abstract provided.

Rigorous Validation Of Machine Learning Models For Orthodontic Extraction Prediction Using Nested Cross-Validation And Smotenc-Integrated Pipelines., Anh Thi-Ngoc Do, Hung Trong Hoang, Thuy-Trang Thi Ho, Hieu Ngoc Le

Journal of Dental Sciences

Background/purpose: Machine learning (ML) in orthodontics often suffers from optimistic bias due to data leakage and improper handling of class imbalance. This study implemented and evaluated a production-grade validation framework - nested cross-validation (CV) - for three distinct algorithm classes (logistic regression, random forest, and gradient boosting) using a consensus-labeled orthodontic dataset.

Materials and methods: A retrospective dataset of 500 patients (334 non-extraction/166 extraction) was curated with 41 processed features. Two stratified split protocols (70/30 and 80/20) were evaluated to assess model robustness. To ensure methodological rigor, a 5-fold outer/3-fold inner nested cross-validation was implemented. Crucially, SMOTENC (synthetic minority over-sampling …

“Who Am I Now As A Mother?” Maternal Identity Negotiation During Children’S College Transition, Si Wang

School of Professional Studies

This study employs narrative positioning analysis to examine how two Chinese mothers in transnational contexts discursively negotiate their maternal identities during their children’s transition to college. Drawing on longitudinal narrative interviews, the analysis advances three interrelated theoretical propositions. First, maternal identity work is revealed as a process of selective cultural bricolage, wherein mothers strategically blend elements from competing scripts of child-centered sacrifice, filial reciprocity, and autonomous individualism to construct a hybrid, workable parental logic. Second, the liminality of this transition precipitates a crucial recentering of the self, a core psychological process as intensive child-focused demands recede. Third, the transnational context …

Constitutionalizing Parents’ Rights, Akshat Agarwal

Case Western Reserve Law Review

No abstract provided.

Tax Breaks For Debt Cancellation, James M. Puckett

Case Western Reserve Law Review

No abstract provided.

Calibrating Agnosticism In Administrative Law: Qualitative Bayesian Reasoning On Bureaucratic Motivation, Kenta Tsuda

Case Western Reserve Law Review

No abstract provided.

Toward A Modern Implementation Of In Re Ratti And A Patent’S Principle Of Operation, Benjamin Fugate

Case Western Reserve Law Review

No abstract provided.