Digital Commons Network^™

Single-Cell Rna Sequencing Suggests Different Progenitor Lineages Between Idh Mutant And Idhwt Glioma, Iyad Alnahhas, Allison Kayne, Mehak Khan, Wenyin Shi

Department of Neurology Faculty Papers

Introduction Single-cell RNA sequencing has elucidated the heterogeneity in cancer. Single-cell glioblastoma (GBM) analyses have also proposed the resemblance of GBM cells to radial glia and outer radial glia (oRG) supporting the hypothesis that remnants of developmental tissue get reactivated in cancer. A recent study isolated neural progenitor cells (NPCs) from developing fetal human brain (gestational week 17-19) and classified NPCs based on their expression of THY1 (CD90), CD24 and EGFR. Ventricular radial glia are THY1⁻CD24⁻EGFR⁺ whereas oRG are THY1⁻CD24⁻EGFR⁻. Early neuron precursors are CD24⁺THY1⁻EGFR …

Where Americans Get And Trust Political Information: Traditional Media Leads, Social Media Grows, Ai Emerges, Hwayong Shin

Weidenbaum Center Survey (WCS) Reports

Where do Americans turn for political information—and which sources do they actually trust? As traditional news organizations struggle with declining public trust (Brenan 2025; Ladd 2012), social media platforms (e.g., Facebook, Instagram, X) and artificial intelligence (AI) tools (e.g., ChatGPT, Gemini, Copilot) are increasingly stepping into the information space (Bode 2016; Podimata & Cen 2025). Yet little is known about how these sources compare in citizens’ minds. This question matters because a well-functioning democracy depends not just on the availability of information, but on which sources individuals use and trust to support informed political judgments (Lupia & McCubbins 2019; Soroka …

Optimal Murine Cd4+ T Cell Priming By Mrna-Lipid Nanoparticle Vaccines Requires Endogenous Antigen Processing, Julia E. Rood, Suh Kyung Yoon, Mary K. Heard, Stephen D. Carro, Emma J. Hedgepeth, Mary E. O'Mara, Michael J. Hogan, Nhu Le, Hiromi Muramatsu, Kieu Lam, Petra Schreiner, Coral Kasden, Hansell H. Stedman, Ryan A. Langlois, James Heyes, Norbert Pardi, Laurence C. Eisenlohr

College of Life Sciences Faculty Papers

Lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA vaccines elicit robust CD4+ T cell responses, yet the mechanisms underlying this T cell priming remain unknown. Antigens presented to CD4+ T cells on major histocompatibility complex class II (MHC II) are traditionally acquired by antigen presenting cells (APCs) from extracellular sources. Here we show that vaccine specific CD4+ T cell responses instead rely on antigen directly expressed within APCs, without extracellular transit. Murine APCs treated with mRNA-LNP vaccines activate T cells more efficiently when presenting antigen produced internally, rather than acquired externally. Immunization with mRNA-LNP vaccines engineered to inhibit antigen expression in APCs results …

Institutional Practices Drive Antibiotic Variability In Neonatal Intensive Care Units: Baseline Evidence To Inform National Stewardship Interventions In Oman, Abdullah Alqayoudhi, Manoj Malviya, Sathiya Murthi, Mohammed Rasik Nv, Adil Said Al-Wahaibi, Raya Al-Habsi, Said Al-Balushi, Talal Alwardi, Agha Hatif Shamsi, Halah Bait Raidan, Aamera Al-Majrafi, Preethi Kiran, Eyad Hani Abu Abu Alhaijaa, Kawther Al Amri, Khalfan Al Abdali, Mohammed S. Al Reesi, Nasser Al-Shafouri, Amal Al-Jabri, Sachin Shah, Said Al-Kindi, Zubair H. Aghai, Mohammed Al-Yahmadi, Amal Al-Maani

Department of Pediatrics Faculty Papers

Background: Antibiotic overuse in Neonatal Intensive Care Units (NICUs) is a major contributor to antimicrobial resistance and adverse neonatal outcomes. This study aims to evaluate baseline antibiotic utilization (AU), identify factors influencing variability, and assess the impact of neonatal characteristics and sepsis incidence. Methods: A multicenter retrospective analysis examined AU in seven NICUs from 2019 to 2023, involving 25,532 neonatal admissions during national antibiotic stewardship program implementation. Data encompassed neonatal clinical parameters, sepsis incidence, and AU metrics, including days of therapy (DOT) per 1000 patient-days. Statistical analyses included correlation assessments and multivariate regression to identify determinants of antibiotic use. Results: …

The Ethical Limits Of Physician Autonomy In Reproductive Medicine, Isabel Martens

Honors Theses

In vitro fertilization is a relatively new medical practice that helps people who face infertility be able to reproduce. Reproductive medicine providers face ethical dilemmas often in their field, only some of which have standards of care. There are questions in the medical landscape pertaining to physician autonomy versus patient autonomy, which heavily apply to reproductive medicine providers. Patient autonomy is highly valued in medical ethics; however, physician autonomy should also be considered. When a physician decides who can and cannot reproduce, ethical considerations must be followed to maintain the practice of reproductive autonomy. Limited policies exist that manage reproductive …

Agenda (1-16-2026), California State University, San Bernardino - Associated Students, Incorporated

Associated Students, Incorporated records

No abstract provided.

Minutes (1-16-2026), California State University, San Bernardino - Associated Students, Incorporated

Associated Students, Incorporated records

No abstract provided.

Elevated Trna Halves In Olfactory Epithelial Cells Of Patients With Schizophrenia, Justin T. Gumas, Megumi Shigematsu, Karin E. Borgmann-Winter, C. G. Hahn, Yohei Kirino

Computational Medicine Center Faculty Papers

Schizophrenia patients' olfactory epithelial cells contain abundant immune-activating tRNA fragments, linking small RNA biology to inflammation and suggesting avenues for diagnostics.

1449 Bushwick Holdings Llc V. Williams

All Decisions

In this non-payment proceeding, the court granted the tenant's pre-answer motion to dismiss the petition without prejudice. The landlord's predicate rent demand was deemed defective for failing to provide a good-faith approximation of rent arrears, specifically by not crediting HRA/DSS earmarked payments. The court found that certified copies of the earmarked HRA/DSS checks, submitted with the tenant's motion, were self-authenticating and did not require a foundational witness. The demand's deficiency led to dismissal of the case.

First Results On The Search For Lepton Number Violating Neutrinoless Double-Β Decay With The Legend-200 Experiment, H. Acharya, N. Ackermann, M. Agostini, A. Alexander, C. Andreoiu, G. R. Araujo, Frank Avignone Iii, M. Babicz, W. Bae, A. M. Bakalyarov, M. Balata, A. S. Barabash, C. J. Barton, L. Baudis, C. Bauer, E. Bernieri, L. Bezrukov, K. H. Bhimani, V. Biancaccu, E. Blalock, Et. Al.

Faculty Publications

The LEGEND Collaboration is searching for neutrinoless double-beta (0νββ) decay by operating high-purity germanium detectors enriched in ⁷⁶Ge in a low-background liquid argon environment. Building on key technological innovations from the GERmanium Detector Array (GERDA) experiment and the MAJORANA DEMONSTRATOR experiment, LEGEND-200 has performed a first 0νββ decay search based on 61.0 kg yr of data. Over half of this exposure comes from our highest performing detectors, including newly developed inverted-coaxial detectors, and is characterized by an estimated background level of 0.5^+0.3_−0.2 cts/(keV ton yr) in the 0νββ decay signal region. A combined …

Rnai-Based Screen For Pigmentation In Drosophila Melanogaster Reveals Regulators Of Brain Dopamine And Sleep, Samantha L Deal, Danqing Bei, Shelley B Gibson, Harim Delgado-Seo, Yoko Fujita, Kyla Wilwayco, Elaine S Seto, Amita Sehgal, Shinya Yamamoto

Faculty, Staff and Students Publications

The dopaminergic system has a large role in behavior and neurological disease, and understanding dopamine level regulation in vivo is critical. To identify dopamine regulators, we utilized Drosophila melanogaster cuticle pigmentation, where dopamine is a precursor to melanin. We measured dopamine from known pigmentation mutants (e.g., tan, ebony, black) and performed an RNAi-based screen to identify additional regulators. We found 153 hits, enriched for developmental signaling pathways and mitochondria-associated proteins. From 35 prioritized candidates, 11 affected head dopamine levels. Effects on brain dopamine were mild, even knocking down the rate-limiting synthesis enzyme Tyrosine hydroxylase (TH), suggesting …

Finnie V. Forbes

All Decisions

In this nonpayment case, the Court granted the tenant's motion for injunctive relief, ordering the landlord to cease harassing acts, provide the front door code, restore and maintain essential services, and ensure proper mail distribution. This decision protects the tenant's right to peaceful occupancy and necessary dwelling conditions.

Host-Specific Fluorescence Dynamics In Legume-Rhizobium Symbiosis During Nodulation, Chandan K. Gautam, Gayathri Senanayake, Amanda B. Pease, Mohamed A. Salem, Ahmed H. Rabia, Birgit M. Prüß, Barney A. Geddes

APC Fund Awardees

The legume-rhizobium symbiosis is a cornerstone of sustainable agriculture due to its ability to facilitate biological nitrogen fixation. Still, real-time visualization and quantification of this interaction remain technically challenging, especially across different host backgrounds. In this study, we systematically evaluate the efficacyefficacyefficacyof the nitrogenase system nifH promoter (PnifH) in driving expression of distinct fluorescent reporters; superfolder yellow fluorescent protein (sfYFP), superfolder cyan fluorescent protein (sfCFP), and various red fluorescent proteins (RFPs) within root nodules of determinate (Lotus japonicus-Mesorhizobium japonicum) and indeterminate (Pisum sativum-Rhizobium leguminosarum) systems. We show that PnifH-driven sfYFP and sfCFP yield strong, uniform, and reproducible fluorescence in nodules …

Usa V. Jarrett Tarn

2026 Decisions

USDC for the Eastern District of Pennsylvania

Usa V. Raymont Bentley

2026 Decisions

USDC for the Western District of Pennsylvania

Human Capital And Development, Philippe Aghion, Ingvild Almås, Costas Meghir

Cowles Foundation Discussion Papers

Human capital is central to efforts to promote growth, convergence, and the elimination of poverty. Drawing on seminal macroeconomic frameworks by Nelson-Phelps, Lucas, and subsequent developments, alongside macro and microeconomic evidence, the chapter examines the role of human capital in driving innovation and growth, emphasizing how different types of human capital matter at different stages of development, and discussing obstacles to accumulation and evidence from policy interventions.

Probability Cueing In Large-Scale Environmental Search: The Role Of Landmark Cues In Statistical Learning, Shaun Dordoy, Rory Baxter, Alastair Smith

School of Psychology

Efficient environmental search is an important and adaptive everyday skill. A particular feature of theoretical interest is whether large-scale search is informed by the spatial statistics of the environment - probability cueing is a robust effect in two-dimensional visual search tasks, but studies of large-scale search have generated equivocal findings. Here, we examined whether sensitivity to a statistical cue specified within an allocentric reference frame is modulated by the presence and location of environmental landmarks. Participants explored fully immersive virtual environments, wherein they were presented with an array of locations (columns) and required to search them for a hidden target …

Exploring The Experience Of Co-Designing Mental Health Services In The National Health Service As An Expert By Experience, Annabelle Mccall, Peta Temple, River Rose, Pete Keohane, Lealah Hewitt-Johns

School of Psychology

PurposeThe number of Experts by Experience (EbE) working in mental health services has grown in recent years. The National Health Service (NHS) five-year plan states EbE should be used across different levels, including service delivery, design and commissioning. While current research explores the role of EbE in service delivery, little is known about their experiences of co-designing services. This study aims to explore EbE experiences of co-designing NHS mental health services.Design/methodology/approachThis research used qualitative semi-structured interviews with ten participants who had worked on projects focused on co-designing NHS mental health services as an EbE. Data were analysed using reflexive thematic …

Masthead, Cleveland State Journal Of Law And Health

Journal of Law and Health

No abstract provided.

Fda's New Approval Plan For Covid-19 Vaccines: An Inquiry Of "Benefit" Rather Than The Statutory Scope Of "Safety, Purity, And Potency"?, Henry Yat-Shing Kwan

Journal of Law and Health

This article analyzes the FDA's proposed policy plan issued in May 2025 regarding the approval of Covid-19 boosters for different groups of persons. It offers two constructive recommendations that will help prevent constitutionality challenge on impermissible intrusion of the freedom of health.

The first is to avoid using the confusing term "benefit" but instead focus on the statutory parameters of "safety, purity, and potency." The affected group can make a strong case that their free choice of vaccination should not be deprived, as long as the vaccine qualifies for the statutory thresholds of being safe, pure, and potent. They are …

Clinicopathological Features Of Colorectal Cancer In Young Patients In Comparison With Older Patients, Bahaa Al-Neama, Wasam Al-Asadi

Iraqi National Journal of Medicine

Background:  Colorectal cancer (CRC) has traditionally been considered a disease of older adults; however, recent evidence shows an increasing incidence among younger patients. Understanding the differences in clinicopathological features between young and older individuals is essential for improving early diagnosis, treatment strategies, and outcomes. Aim: The primary objective of this study is to compare the demographic profiles and clinicopathological characteristics of younger patients (aged <40 years) with those of older patients (aged ≥40 years) diagnosed with colorectal cancer. Methods: Eighty-five consecutive patients admitted to our hospital were prospectively followed for their entire hospital stay or up to 7 days, whichever came first. Each patient's blood glucose measurement was recorded according to ward protocol. Indices included total blood glucose per ward, per patient-day, or patient stay, and percentage blood glucose levels per predefined cut points to assess the incidence of hypo-, eu-, and hyperglycemia. The trial registration number at Clinicaltrials.org is NCT04800861. Results: Total data consisted of 645 blood glucose tests from 85 patients and 284 patient-day results, with an average of 2.27 tests per patient-day and 7.59 measurements per patient stay. The percentage of blood glucose in the range (80–180 mg/dL) varied by model, with patient-day showing the highest results at 48.24%, while the percentage of patients with hypoglycemia (blood glucose <60 mg/dL) was highest per patient stay at 1.18%. Conclusions: Younger colorectal cancer patients in this study presented more frequently with rectal tumors, poor differentiation, and advanced disease stages. Despite similar symptom profiles, delayed diagnosis may contribute to worse pathological features. These findings support the need for greater awareness and consideration of earlier screening in younger populations.

Do Upside-Down Jellyfish Influence Marine Macrofauna Assemblages?, Juleika Y. Vega Pérez, Natalia B. Lopez-Figueroa, Sebastian Digeronimo, Michael J. Schram, Milton Muñoz Hincapie, Elizabeth Stoner, Pamela Hallock

Making Waves REU

• Estuaries are essential ecosystems for many organisms as they serve as spawning areas and nurseries
• Macrofauna are crucial members of estuarine ecosystems
• Many estuary macrofauna are considered of commercial importance
• Jellyfish blooms can alter nutrient cycling and modify habitat
• Little is known about how other macrofauna respond to Cassiopea blooms
• This study documents composition and diversity of macrofauna associated with Cassiopea blooms in Jobos Bay, Puerto Rico

Menagerie: Animals In Art From The Kam Collection, Kruizenga Art Museum, Lisa Barney

Kruizenga Art Museum Posters

A poster for the exhibition Menagerie: Animals in Art from the KAM Collection held January 16–May 16, 2026.

Kruizenga Art Museum Online Collection - Exhibition Gallery

Modern Pioneers: The Artistic Collaboration Of Martha Graham And Barbara Morgan, Kruizenga Art Museum, Lisa Barney

Kruizenga Art Museum Posters

A poster for the exhibition Modern Pioneers: The Artistic Collaboration of Martha Graham and Barbara Morgan held January 16–May 16, 2026.

Kruizenga Art Museum Online Collection - Exhibition Gallery

Distribution System Reliability Evaluation Considering Protection Coordination Using Petri Nets, Rani Kumari, Bhukya Krishna Naick

Turkish Journal of Electrical Engineering and Computer Sciences

Maintaining reliable and high-quality power delivery becomes increasingly complex with expanding power grids. The lack of protection coordination poses a significant threat, compromising overall system reliability. This research addresses this challenge by proposing a method for coordinating protective devices within the distribution system, specifically during network faults. The proposed approach utilizes a stochastic timed Petri net (STPN) based methodology to model protective device coordination across various fault scenarios. This technique effectively captures the dynamic behavior and interactions of protective equipment, allowing for the anticipation of potential disturbances. This proactive insight facilitates preventative measures to address prewarning situations, thereby preventing cascading …

Book Review: The Politics Of War And Peace: A Survey Of Thought, Isaiah Wilson Iii

Parameters Bookshelf – Online Book Reviews

Authors: Abbott A. Brayton and Stephana J. Landwehr

Reviewed by: Dr. Isaiah “Ike” Wilson III (colonel, US Army retired); professor of practice, Arizona State University; and president emeritus, Joint Special Operations University

Spanning centuries of political and philosophical reflection, Brayton’s work explores how thinkers from ancient times to the modern era have grappled with the moral and strategic dilemmas of war and peace. Through a rich tapestry of ideas, the book reveals the enduring tensions between justice, power, and diplomacy. It’s an essential guide for understanding how past wisdom continues to shape contemporary debates on conflict and resolution.

Copyright: ©2026 …

A Programmable Genetic Platform For Engineering Noninvasive Biosensors, Asish N Chacko, Kaamini M Dhanabalan, Jinyang Wan, Roy Chien, Nolan T Anderson, Binzhi Xu, Katie Pham, Ritu Tiwari, Arnab Mukherjee

Faculty, Staff and Student Publications

Creating genetic sensors for noninvasive visualization of biological activities in optically opaque tissues holds immense potential for basic research and the development of genetic and cell-based therapies. Magnetic resonance imaging (MRI) stands out among deep tissue imaging methods for its ability to generate high-resolution images without ionizing radiation. However, the adoption of MRI as a mainstream biomolecular technology has been hindered by the lack of adaptable methods to link molecular events with genetically encodable contrast. Here, we introduce modular aquaporin-based protease-activatable probes for enhanced reporting (MAPPER), a platform for the systematic creation of genetic sensors for MRI. To develop MAPPER, …

Ai-Enabled Decision-Support Systems In The Joint Targeting Cycle: Legal Challenges, Risks, And The Human(E) Dimension, Jessica Dorsey, Marta Bo

International Law Studies

Israel’s military campaign in Gaza as well as ongoing conflicts in Ukraine, Yemen, Iraq, and Syria include the reported military use of AI-enabled decision-support systems (AI-DSS) within the joint targeting cycle (JTC). These tools use AI techniques to collect and analyze data, provide information about the operational environment, and make actionable recommendations with the aim of aiding military decision-makers in evaluating factors relevant to legal compliance, such as taking precautions and ensuring proportionality in attacks. These systems are often touted as being simply a human aid and, as such, have flown largely under the radar regarding regulation as they are …

Leadless Versus Transvenous Dual-Chamber Pacemakers: Real-World Evidence From Aveir Dr Coverage With Evidence Development Study., Monica Lo, Anish K Amin, Marcin Kowalski, Anne Kroman, Dilip Mathew, Valay Parikh, Stanislav Weiner, Jennifer M Joseph, Leonard Ganz, Mohammed Mortada

Heart and Vascular Articles

BACKGROUND: AVEIR DR, an industry-first dual-chamber leadless pacemaker (LP), provides continuous atrioventricular synchrony through implant-to-implant (i2i) communication between atrial and ventricular LP devices. It is important to evaluate the early real-world comparative safety of AVEIR DR LP.

OBJECTIVE: To compare complications and mortality between AVEIR DR LP and dual-chamber transvenous pacemakers (TP).

METHODS: De novo LP and TP patients were identified in Medicare Fee-for-Service claims (October 2023 and December 2024). Outcomes were 30-day and 6-month complications, reinterventions, heart failure hospitalizations, and all-cause mortality. Comparisons were adjusted for demographics, comorbidities, and hospital encounter characteristics.

RESULTS: Compared to TP (N = 77 …

The Itrail Making Test (Itmt): An Evaluation Of Novel Testing Paradigms, Hidden Indices Of Measurement, And Diagnostic Accuracy In Parkinson’S Disease, Donnchadh Murphy, Jonathan Scott, Craig Newman, Rupert Noad

Peninsula Medical School

Introduction: The Trail Making Test (TMT) is an important test when assessing for cognitive difficulties in people with Parkinson’s Disease (PD). However, the pencil-and-paper format can be susceptible to administration and scoring errors and may disproportionately reflect motor impairments rather than cognitive performance. The current study sought to evaluate the reliability and diagnostic accuracy of two novel computerized versions of the TMT: iTMT-Tap and iTMT-Drag. Method: This study used a quasi-experimental diagnostic accuracy design, and included 34 healthy controls, 28 people with Parkinson’s disease with normal cognition (PD-NC), and 31 people with Parkinson’s disease mild cognitive impairment (PD-MCI). Participants were …