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High Algal Biomass Is Decoupled From Metabolism In The Gallatin River, Cora Mae Steinbach Jan 2026

High Algal Biomass Is Decoupled From Metabolism In The Gallatin River, Cora Mae Steinbach

Graduate Student Theses, Dissertations, & Professional Papers

Assessing eutrophication in rivers is difficult compared to lakes and coastal waters, because most algal biomass occurs on the riverbed and flows interact and co-vary with production (Biggs and Close, 1989; Bernhardt et al., 2018). Riverine eutrophication is typically assessed using algal biomass and water column nutrients (U.S. Environmental Protection Agency, 2000), but biomass is highly variable and labor-intensive to measure, while nutrient concentrations often underestimate enrichment due to rapid biological uptake (Dodds and Smith, 2016). Reach-scale river metabolism can help evaluate long-term functional change in rivers recovering from nutrient enrichment (Arroita et al., 2019; Jankowski et al., 2021; Diamond …


Race, Sexual Danger, And The Moral Logic Of Punishment In The Registry Era, Edith Meade Jan 2026

Race, Sexual Danger, And The Moral Logic Of Punishment In The Registry Era, Edith Meade

Graduate Student Theses, Dissertations, & Professional Papers

Sex offender registries represent one of the most expansive and punitive criminal justice interventions in modern American history, yet public support for these policies remainsunderi nvestigated. Scholarly debate has questioned whether punitive attitudes toward sexual offenders reflect principled moral judgments, racial threat perceptions, or both. This study addresses that question by examining how offender race, offender age, offense severity, victim age, and offender-victim relationship shape public attitudes toward sexual offenders in the contemporary registry era. Drawing on theories of racialized sexual threat, group position, and retributive impulses, the study uses a nationally representative conjoint survey experiment administered through YouGov (N …


The Experience Of A Single Parent Participating In Child-Parent Relationship Therapy: An Instrumental Single-Case Study, Matthew Nicholas Schramm Jan 2026

The Experience Of A Single Parent Participating In Child-Parent Relationship Therapy: An Instrumental Single-Case Study, Matthew Nicholas Schramm

Graduate Student Theses, Dissertations, & Professional Papers

Traditional family structures in the United States have shifted significantly, with single-parent households facing systemic barriers that increase parental stress and strain the parent-child relationship. As this bond is critical for healthy child development, accessible mental health support is essential for these families (Parache et al., 2023).

Child Parent Relationship Therapy (CPRT), a ten-week evidence-based program, strengthens this bond by training caregivers to use play as a therapeutic tool (Landreth & Bratton, 2020). This instrumental single case study (Stake, 1995) examined one single-parent's experience of CPRT delivered in a condensed four-week telehealth format, addressing the limited representation of single-parent households …


Proactive Safety Reasoning In Human-Robot Collaboration In Disassembly Through Llm-Augmented Stpa And Fmea, Morteza Jalali Alenjareghi, Fardin Ghorbani, Samira Keivanpour, Yuvin Adnarain Chinniah, Sabrina Jocelyn Jan 2026

Proactive Safety Reasoning In Human-Robot Collaboration In Disassembly Through Llm-Augmented Stpa And Fmea, Morteza Jalali Alenjareghi, Fardin Ghorbani, Samira Keivanpour, Yuvin Adnarain Chinniah, Sabrina Jocelyn

Études primaires

Disassembly tasks in human–robot collaboration (HRC) environments present safety challenges due to hazardous materials, control system variability, and physically demanding operator tasks. To address these challenges, we propose an AI-augmented risk assessment framework integrating System-Theoretic Process Analysis (STPA) and Failure Mode and Effects Analysis (FMEA). This framework is implemented in four configurations: Term Frequency– Inverse Document Frequency (TF-IDF), Fine-tuned Large Language Models (LLMs), Retrieval-Augmented Generation (RAG), and RAG with a structured Knowledge Graph (KG) built from safety standards. The system supports real-time, standards-compliant safety reasoning by generating interpretable, context-specific recommendations. We evaluate these configurations across GPT-3.5 TURBO, GPT-4o, GPT-4.1, and …


An Llm-Driven System For Doctor-Patient Simulation, Akilan Amithasagaran Jan 2026

An Llm-Driven System For Doctor-Patient Simulation, Akilan Amithasagaran

Computer Science Theses

Effective physician-patient communication is fundamental to clinical competence, yet traditional simulation-based training methods using standardized patients and high-fidelity manikins are costly, resource-intensive, and difficult to scale. This dissertation presents CLiVR (Conversational Learning system in Virtual Reality), an LLM-driven system that integrates large language models and 3D avatars to simulate doctor-patient interactions for medical communication training.

CLiVR addresses three key limitations in existing virtual reality medical training platforms. First, the system operates on standalone Meta Quest 3 hardware with realistic 3D patient avatars featuring synchronized lip movements and speech-based interaction. Second, CLiVR grounds LLM responses using a curated syndrome-symptom database, constraining …


Fear, Uncertainty, And The Chilling Effect: A Case Study Of Organizational Racialized Omission, Annie Jones Jan 2026

Fear, Uncertainty, And The Chilling Effect: A Case Study Of Organizational Racialized Omission, Annie Jones

Graduate Studies Theses and Dissertations 2026

Florida passed House Bill 7 in 2022 and Senate Bill 266 in 2023, both policies that restrict how race and racism are discussed and taught in the public higher education setting. Although scholars of race and racism contend that colorblind ideology drives the “new racism,” the U.S. is experiencing a resurgence in similar curriculum bans explicitly based on topics related to race and racism. With these trends has emerged a need to understand how explicitly racialized policies fit within the “new racism” framework. Using Victor Ray’s Theory of Racialized Organizations, this study analyzes how colorblind ideology and racialized threat are …


Perception Matters: A Case Study Exploring How Belief Systems Affect Family-School Partnerships And Family Literacy Initiatives In A Title I School, Kwtay Calvin Jan 2026

Perception Matters: A Case Study Exploring How Belief Systems Affect Family-School Partnerships And Family Literacy Initiatives In A Title I School, Kwtay Calvin

Dissertations

Family-school partnerships have been shown to have positive effects on students’ overall performance in school. However, in many instances schools have not used partnerships effectively to support literacy learning, particularly for Black families. Teacher bias, negative perceptions, and lack of cultural responsiveness hinder teachers’ effort to build meaningful relationships with Black families to best support family literacy. This qualitative study aimed to examine family-school partnerships through the experiences of school principals, teachers, and Black families to gain insight into the factors that impact collaborative relationships and family literacy support. This study is framed in critical race theory, the theory of …


An Ecological-Evolutionary Investigation Of Phenotypic, Genetic, And Environmental Variation And Correlations Among Reproductive Traits Of Tall Goldenrod (Solidago Altissima), Michael J. Wise, Daniel Lavy, David E. Carr, Warren G. Abrahamson Ii Jan 2026

An Ecological-Evolutionary Investigation Of Phenotypic, Genetic, And Environmental Variation And Correlations Among Reproductive Traits Of Tall Goldenrod (Solidago Altissima), Michael J. Wise, Daniel Lavy, David E. Carr, Warren G. Abrahamson Ii

Faculty Journal Articles

Although fitness-related traits are expected to be under strong selection, traits related to reproduction are often quite variable within plant populations. We used data from two large greenhouse experiments to quantify phenotypic, genetic, and environmental variation, as well as genetic tradeoffs that might help explain the maintenance of withinpopulation variation in four traits related to sexual or vegetative reproduction in tall goldenrod (Solidago altissima). The goldenrod population exhibited high levels of both phenotypic and genetic variation for capitulum (flower head) number and size, seed production, and rhizome growth. Significant negative genetic correlations were present between the number of capitula and …


Bilingual Teacher Advocacy, Agency, And Leadership: A Model For Teacher Education And Professional Development, Grace Jue Yeon Kim, Zhenjie Weng, Jingyi Zhu Jan 2026

Bilingual Teacher Advocacy, Agency, And Leadership: A Model For Teacher Education And Professional Development, Grace Jue Yeon Kim, Zhenjie Weng, Jingyi Zhu

Faculty Journal Articles

Research has examined bilingual teachers’ work and their

experiences through the theoretical lens of teacher advocacy,

teacher agency, and teacher leadership. This research synthesis

analyzes the current research on the three frameworks in bilingual

education and examines how they intersect. Bilingual teachers

advocated for educational change to address the needs of

emergent bilinguals. Despite various context-specific constraints,

bilingual teachers agentively created bilingual spaces for

linguistically diverse students. Furthermore, bilingual teachers

actively took up leadership roles, demonstrated increased

consciousness, and developed leadership identities. Through this

exploration, this paper proposes a model that integrates the three

frameworks for bilingual teacher education and …


Scalar Source Localization Using Multi-Sensor Domains Of Dependence In Turbulent Channel Fow, Zejian You, Xiaowei Zhu, Qi Wang Jan 2026

Scalar Source Localization Using Multi-Sensor Domains Of Dependence In Turbulent Channel Fow, Zejian You, Xiaowei Zhu, Qi Wang

Mechanical and Materials Engineering Faculty Publications and Presentations

Tracking hazardous events such as wildfire smoke, coastal oil spills, or chemical releases in natural environments is complicated by turbulent dispersion and molecular diffusion. This study presents a method to localize pollutant sources rapidly and accurately using infinite time-averaged measurements from a multi-sensor network, leveraging the duality between mean forward and adjoint scalar fields. The forward-adjoint duality states that measurements at the sensor (forward feld) are equal to the adjoint field at the source, providing crucial spatial information about the source. Consequently, the adjoint scalar fields can be interpreted as the domain of dependence for the sensor observations [1, 2]. …


From Community College To Degree: Examining The Success Of Undocumented Community College Transfer Students, Carmen Celina Macias Limon Jan 2026

From Community College To Degree: Examining The Success Of Undocumented Community College Transfer Students, Carmen Celina Macias Limon

CGU Theses & Dissertations

This qualitative dissertation explored the academic trajectories of 31 undocumented Latinx students in California who began their postsecondary education at community colleges and graduated from 4-year institutions. Guided by the undocumented community of trust model, which integrates Yosso’s (2005) community cultural wealth framework, Coleman’s (1994) theory of trust, and the newly introduced concept of alliance capital, this study examined how students leveraged seven forms of capital (i.e., aspirational, familial, navigational, social, resistance, linguistic, and alliance) to overcome educational barriers. It also examined the factors that shaped undocumented community college students’ willingness to trust and disclose their immigration status. Using a …


The Impact Of Ai Recommendation Features On Consumer Purchasing Decisions In E-Commerce Environments, Abdullah Alrumi Jan 2026

The Impact Of Ai Recommendation Features On Consumer Purchasing Decisions In E-Commerce Environments, Abdullah Alrumi

CGU Theses & Dissertations

Artificial intelligence recommendation features such as visual search, real-time offers, chatbot interactions, and generative recommendations have become central to e-commerce. A key gap remains because most studies focus on purchase intention instead of actual decisions and examine these AI features separately. This study addresses this gap by asking: What is the impact of AI recommendation features on consumer purchasing decisions in e-commerce environments? Using a sequential mixed-methods design in the Saudi Arabian e-commerce market, the quantitative phase surveyed 343 online shoppers analyzed with PLS-SEM, while the qualitative phase involved 15 interviews analyzed thematically with ATLAS.ti. The conceptual model was informed …


(R)Evolutionary Cultural Literacy: Pauli Murray’S Boundary-Crossing Tripartite Pedagogy, Lorise Ann Diamond Jan 2026

(R)Evolutionary Cultural Literacy: Pauli Murray’S Boundary-Crossing Tripartite Pedagogy, Lorise Ann Diamond

CGU Theses & Dissertations

Civil rights lawyer, poet, activist, questioning, and Episcopal priest Pauli Murray spent seven decades generating legal doctrine, autobiography, poetry, and institutional redesign across some of the most hostile yet fecund terrain American public life produced. Scholarship across rhetoric and writing studies, cultural studies, Black feminism, and critical pedagogy has theorized literacy, movement, and commons-making as separate concerns. What the field of cultural literacy lacks is a framework that holds those concerns together, reads them through a focused body of texts, and translates them into a transferable pedagogy applicable across academic, civic, and institutional settings. This dissertation argues that cultural literacy …


How Teachers Learn Strategies To Support Students With Individualized Education Programs Through The Use Of Multi-Tiered Systems Of Support, Behrose Foroughi Jan 2026

How Teachers Learn Strategies To Support Students With Individualized Education Programs Through The Use Of Multi-Tiered Systems Of Support, Behrose Foroughi

CGU Theses & Dissertations

This dissertation study captured how teachers learn strategies to support students with Individualized Education Programs (IEPs) through the use of Multi-Tiered Systems of Support (MTSS). In the MTSS framework, Tier 1 serves approximately 80–85% of students with high-quality evidence-based core instruction (e.g., science of reading curriculum, social emotional curriculum); Tier 2 serves approximately 10–15% with targeted small-group interventions (e.g., data-informed small-group math/reading groups, check-in/check-out behavior programs); Tier 3 serves approximately 5% with intensive individualized support (e.g., Orton-Gillingham reading intervention groups, individualized behavior plans). Special Education is a separate, legally mandated service outside the tiers for students with identified disabilities under …


Shaping Shakespeare: How American Shakespeare Festivals Adapt Shakespeare’S Texts In The Twenty-First Century, Paul Jacques Jan 2026

Shaping Shakespeare: How American Shakespeare Festivals Adapt Shakespeare’S Texts In The Twenty-First Century, Paul Jacques

CGU Theses & Dissertations

Shakespeare’s continued importance in American festival settings stems from adaptive and collaborative processes. In this study, adaptation refers to any reinterpretation of Shakespeare's works for contemporary contexts, while collaboration refers to the combined creative efforts among artists and institutions. These processes, including reinterpretation, modernization, and partnership, propel performance and underpin Shakespeare festivals. Such festivals play a central role, balancing cultural prestige with institutional sustainability by prioritizing long-term viability and financial health. At the same time, festivals respond to local audiences' beliefs and interests. Instead of presenting static versions, these institutions continually interpret, revise, and adapt the canon, the authoritative collection …


Essays On Election, Bianca Appel Kranzler Jan 2026

Essays On Election, Bianca Appel Kranzler

CGU Theses & Dissertations

This dissertation focuses on electoral accountability at the local and national levels. The first chapter focuses on judicial elections in Houston, while the last two chapters forecast the 2024 national election. This first chapter examines whether changes in local crime rates influence voter behavior in partisan judicial elections. Using precinct-level crime and election data from Houston, Texas, this study tests whether a quarterly increase in crime raises the probability that a voting precinct flips from a Democratic to a Republican majority in local district judge elections. A two-way fixed-effects model with precinct and year fixed effects is estimated across seven …


Bail Reform, Large Language Model Risk And Reasoning, William Wyatt Jan 2026

Bail Reform, Large Language Model Risk And Reasoning, William Wyatt

CGU Theses & Dissertations

This dissertation contains three studies. Each asks how rules or language change the choices people and machines make when outcomes are uncertain. The first study, written with Kiran John, evaluates California’s 2020 cashless bail reform. We use propensity score matching on arrestee records from the windows before and after implementation, and we test whether the shift away from cash bail produced any effect on subsequent offending. It did not. Matched comparisons yield small, statistically insignificant differences across every window we examined. That null result cuts against both sides of the public argument. The reform did not drive a spike in …


Effect Of Female Employment On Household Expenditure In Bangladesh, Fatema Binte Sharif Jan 2026

Effect Of Female Employment On Household Expenditure In Bangladesh, Fatema Binte Sharif

Electronic Theses and Dissertations

Female labor force participation (FLFP) in Bangladesh has increased from 29.2% in 2005–06 to 42.8% in 2022, raising important questions about household resource allocation. This study examines the impact of female employment on household expenditure patterns and challenges the traditional unitary model of decision-making. It focuses on how income controlled by women influences spending across essential and non-essential categories. The analysis uses data from the Household Income and Expenditure Survey (HIES) conducted by the Bangladesh Bureau of Statistics. This research employs Seemingly Unrelated Regression (SURE) approach to estimate budget shares for food, housing, health, education, clothing, and transport. The study …


Glaucoma Risk With Metformin And Sulfonylurea Therapies In Type 2 Diabetes: A Retrospective Cohort Study., Jared Lim, Jingru Zhou, Hulin Wu, Ziqi Liu, David A Lee Jan 2026

Glaucoma Risk With Metformin And Sulfonylurea Therapies In Type 2 Diabetes: A Retrospective Cohort Study., Jared Lim, Jingru Zhou, Hulin Wu, Ziqi Liu, David A Lee

Faculty, Staff and Student Publications

Background: Research on metformin, sulfonylureas, and open-angle glaucoma risk in type 2 diabetes mellitus (T2DM) has yielded inconsistent findings. This study examined associations between hypoglycemic treatments and glaucoma diagnosis rates.

Methods: This retrospective cohort study analyzed electronic health records of newly diagnosed T2DM patients from the Merative™ Explorys® Therapeutic Dataset (2010-2022), comparing three groups: metformin monotherapy, sulfonylureas plus metformin combination, and untreated controls. Propensity score matching balanced demographics, glycemic control, body mass index, blood pressure, lipid levels, and comorbidities. Cox proportional hazards models calculated adjusted hazard ratios for incident glaucoma.

Results: After 1:1 propensity score matching, metformin monotherapy (N=100,387) showed …


Retirement: Broaching Intersectional Identities And Aging, Nichole Tiggs Angieri, Ericka Cables, Mary Martha Abernathy Jan 2026

Retirement: Broaching Intersectional Identities And Aging, Nichole Tiggs Angieri, Ericka Cables, Mary Martha Abernathy

Adultspan Journal

Broaching intersectional identities in retirement is a crucial counseling skill that fosters trust and connection with older adults as they navigate this major life transition. Using Person-Centered, Trauma-Informed (PCTI) and Relational-Cultural Theory (RCT) as complements to broaching, these theories provide both relational and cultural attunement to facilitate healing and well-being in this specialized population. Through didactic information and case studies, the purpose of this conceptual paper is to provide counselors and counselor educators with insight into broaching intersectional identities in retirement and to advocate for further research on aging and identity. The implications for clinical practice include providing an integrated …


A Wellness Approach To Aging, Retirement, And Suicide Risk: Gerontological Considerations, Seth T. Robinson, Derek J. Lee Jan 2026

A Wellness Approach To Aging, Retirement, And Suicide Risk: Gerontological Considerations, Seth T. Robinson, Derek J. Lee

Adultspan Journal

Suicide risk in older adulthood represents complex interactions between developmental transitions; changing social contexts; and interactions between ecological context and individual perceptions of belongingness, burdensomeness, and hope. This paper presents an integrative,developmentally appropriate framework for conceptualizing and addressing suicide risk in older adulthood, which is grounded in the Indivisible Self model of wellness. Drawing on current empirical knowledge of wellness, suicidality, and older adulthood, this paper presents risk and protective factors associated with older adulthood through life transitions, changing social contexts, and other relevant factors. We present a novel integration of suicide intervention, wellness, and holistic care as a suitable …


Full-Time Career Retirement: A Black Man’S Narrative Of Survival And Protecting His Peace, Demetrius Cofield, Amaya Rakes Jan 2026

Full-Time Career Retirement: A Black Man’S Narrative Of Survival And Protecting His Peace, Demetrius Cofield, Amaya Rakes

Adultspan Journal

Full-time career retirement is a major developmental transition that is often examined through race-neutral frameworks, leaving Black men’s experiences underexplored in counseling and aging scholarship. This perspective article centers the narrative of a retired Black man veteran who transitioned into full-time career retirement after decades of state employment. Using a narrative interview approach, this manuscript examines the factors that shaped his retirement decision and adjustment to later adulthood. The interview frames retirement as a process of self-preservation, continuity, and intentional living rather than identity loss or disengagement. Findings highlight the role of disciplined wellness practices and selective disengagement in promoting …


Structural And Intersectional Factors In Full Retirement: Insights For Black Men, Waleed Sami Jan 2026

Structural And Intersectional Factors In Full Retirement: Insights For Black Men, Waleed Sami

Adultspan Journal

This interview centers the full retirement experience of Anthony Crawford. This perspective highlights the complex interplay between social determinants, intersectional identity, the psychology of working, and social class/social mobility, as key factors in his lived experiences. The relationship between structural factors and interpersonal factors continues to be a growth edge in counseling, as counselors frequently report lack of knowledge or comfort in their relationship with counseling. This interview seeks to fill the gap and demonstrate a concrete way to develop clinical insights. The full interview is transcribed and provided, along with practical and research implications for counselors working with populations …


Retirement As A Psychosocial Transition: A Social Determinants Of Mental Health Framework For Counseling Practice, Janelle L. Jones, Lauren Robins, Melanie Calhoun, Aaliyah Bond-Richardson, Latesha S. Holloman, Zoe N. Stuckey Jan 2026

Retirement As A Psychosocial Transition: A Social Determinants Of Mental Health Framework For Counseling Practice, Janelle L. Jones, Lauren Robins, Melanie Calhoun, Aaliyah Bond-Richardson, Latesha S. Holloman, Zoe N. Stuckey

Adultspan Journal

Retirement is commonly framed as a normative and voluntary developmental milestone; however, access to a psychologically healthy retirement is unevenly shaped by social, economic, and structural conditions. This conceptual article applies a social determinants of mental health (SDMH) framework to retirement, conceptualizing it as a complex psychosocial transition involving identity change, shifts in purpose and meaning, relational adjustment, and emotional variability. Drawing on interdisciplinary scholarship, the manuscript examines how socioeconomic status, race and ethnicity, gendered work histories, caregiving responsibilities, health status, and access to benefits influence both the ability to retire and the experience of retirement itself. Particular attention is …


A Systematic Review Of Psychosocial Interventions For Improving Well-Being In Retired Adults, Sakir Yilmaz, Mustafa Filiz Jan 2026

A Systematic Review Of Psychosocial Interventions For Improving Well-Being In Retired Adults, Sakir Yilmaz, Mustafa Filiz

Adultspan Journal

The transition to retirement is a critical biopsychosocial stage that often brings challenges such as shifting roles and reduced income, which may lead to psychological distress. In this study, we systematically synthesized quantitative evidence on the effectiveness of psychosocial interventions in enhancing well-being (increase in positive functioning) among retired adults. A comprehensive search across PubMed, Scopus, Web of Science, and Cochrane was completed in October 2025. This was supplemented by Google Scholar and reference list screening, identifying 5,945 database records and 123 additional sources. After screening and eligibility assessment, seven studies met the inclusion criteria. Across these studies, interventions produced …


Frame: Fast Reference-Based Ancestry Makeup Estimation Tool, Pramesh Shakya, Ardalan Naseri, Degui Zhi, Shaojie Zhang Jan 2026

Frame: Fast Reference-Based Ancestry Makeup Estimation Tool, Pramesh Shakya, Ardalan Naseri, Degui Zhi, Shaojie Zhang

Faculty, Staff and Student Publications

Motivation: The availability of large-scale genetic data presents a unique opportunity to study the genetic ancestries of individuals, which requires an efficient and scalable method. The existing global ancestry methods are accurate, but they cannot scale to large genetic datasets. Identity-by-descent (IBD) segments are DNA segments shared by individuals such that they are inherited from a common recent ancestor without recombination. These IBD segments, which reflect co-ancestry, provide an efficient alternative for inferring genetic ancestry.

Results: We introduced a reference-based global ancestry inference method called FRAME (Fast Reference-based Ancestry Makeup Estimation). FRAME utilizes partial local ancestry information estimated through IBD …


“We’Re All In The Struggle Together”: The Experiences Of First-Generation Graduate Students During Covid-19, Rebecca Stallworth, Danielle E. Maurici-Pollock, Jade Obler, Rachel A. Starr Jan 2026

“We’Re All In The Struggle Together”: The Experiences Of First-Generation Graduate Students During Covid-19, Rebecca Stallworth, Danielle E. Maurici-Pollock, Jade Obler, Rachel A. Starr

Publications

This study explores the experiences of first-generation graduate students (FGGS) during the COVID-19 pandemic, specifically the positive and negative impacts of the pandemic on their learning experiences and their implications for the design of online graduate programs that foster a sense of belonging.


Designing Library Materials And Programming To Enhance Hsc Author Visibility, Will White Jan 2026

Designing Library Materials And Programming To Enhance Hsc Author Visibility, Will White

HSC Education Days

No abstract provided.


Root To Rise: Whole Health Centered Leadership For The Future Physician, Alisa Illescas Jan 2026

Root To Rise: Whole Health Centered Leadership For The Future Physician, Alisa Illescas

HSC Education Days

No abstract provided.


Endothelin-1 In The Failing Fontan: Pathobiology, Precision Therapeutics, And Future Trial Design, Iman Maiza Jan 2026

Endothelin-1 In The Failing Fontan: Pathobiology, Precision Therapeutics, And Future Trial Design, Iman Maiza

Department of Pediatrics Faculty Publications

The Fontan circulation, devised as definitive palliation for single-ventricle congenital heart disease, imposes systemic venous hypertension, loss of pulmonary arterial pulsatility, and restricted preload reserve. These hemodynamic trade-offs progressively injure the pulmonary vasculature, liver, and lymphatic system, producing late morbidities including elevated pulmonary vascular resistance, Fontan-associated liver disease (FALD), protein-losing enteropathy, and arrhythmias. Endothelin-1 (ET-1), a potent vasoconstrictor and profibrotic mediator, plausibly unifies these complications. Mechanistic studies demonstrate ET-1 upregulation in failed Fontan lungs, activating PLC–Ca²⁺, RhoA/ROCK, and MAPK/ERK cascades to drive vasoconstriction and remodeling. In cirrhotic livers, ET-1 localizes to stellate cells, promoting contraction and fibrogenesis, mechanisms biologically relevant …