Targeting The Cd47/Calreticulin Axis In Triple Negative Breast Cancer Using Ha Grafted Chitosan Nanoparticles Loaded With Doxorubicin And Polygodial, Hadir M. Emara

Theses and Dissertations

Background: Triple-negative breast cancer (TNBC) is considered the most aggressive subtype of breast cancer. Although progress in cancer treatment has led to better results for different types of breast cancer, TNBC remains particularly challenging due to persistent resistance to both chemotherapy and immunotherapy. This resistance ultimately renders chemotherapy less effective and is frequently associated with substantial side effects. Immunosurveillance significantly impacts the onset of cancer, the rise of resistance to therapies, and the likelihood of tumor recurrence. In this immunomodulatory process, Cluster of Differentiation 47 (CD47) and Calreticulin (CALR) are two key regulators. CD47 expression is strongly linked to anti-phagocytic …

Copper Metal Organic Framework-Based Nanomaterial For Non-Enzymatic Glucose Electrochemical Sensor, Sameha Mohamed Sadek

Theses and Dissertations

This thesis examines the development of non-enzymatic glucose sensors by engineering advanced electrode materials based on metal-organic frameworks (MOFs). Conventional enzymatic glucose sensors, although widely used, suffer from inherent limitations, including poor long-term stability, narrow operating conditions, and sensitivity to environmental factors, due to their reliance on biological enzymes. Non-enzymatic sensors offer a more robust alternative by enabling direct electrochemical oxidation of glucose on engineered electrode surfaces. MOFs represent a highly tunable class of hybrid materials with structural and chemical features that are ideal for sensor applications, including a high surface area, tailored porosity, and excellent thermal and chemical stability. …

The Philosophy Of Selling Community: Developer Narratives And Resident Experiences Of Privacy And Community In Gated Communities In Cairo, Yosr Samir Raghib

Theses and Dissertations

Gated communities have become a global urban form with diverse impacts on their inhabitants. In recent years, Cairo has been expanding to the edges, and land that has always been a desert is now rapidly transforming into new cities that people are leaving their homes in the center of the city to move to seeking seclusion, security, privacy, and sense of community. Despite the tension proven between privacy and community, developers attempted to sell both concepts to coexist in gated communities in different manners to express their unique brand. Both concepts are defined differently by each developer, resulting in different …

Emergency At The Borders: Response To Refugees In Sallum Camp, Shaimaa Hy Hassanein

Theses and Dissertations

This thesis examines the emergency humanitarian response at Sallum camp at the Egyptian border upon the Lybian crisis between 2011 and 2014. By positioning the lived experiences and perspectives of humanitarian aid workers at the center, this research argues that the camp constituted a distinct and dynamic space shaped by shifting geopolitical conditions, state sovereignty concerns, and bureaucratic ambiguity. Drawing on qualitative interviews with frontline humanitarian aid workers who operated and lived in the camp over extended periods, the study explores how humanitarian interventions were negotiated, adapted, and implemented within a highly constrained environment.

The thesis highlights the Egyptian state’s …

Teachers’ Perception And Challenges Of Online Education In Uae: A Quantitative Study, Ghadah Al Murshidi, Laila Mohebi, K. Kavitha, Roohi Kursheed Khan, Ahmed Al Zaabi

All Works

This study analyzes survey data from teachers in UAE educational institutions to examine their perceptions towards the benefits and challenges of online learning, with a focus on student engagement, technical barriers, and instructional effectiveness. In light of changing educational paradigms, the study examines teachers’ perceptions of online learning success and the challenges it presents, including technical issues, concerns about student involvement, and academic integrity. A survey was conducted among teachers in the UAE to gather data on online education, ensuring representation across genders, age groups, educational backgrounds, and geographic areas. The study highlights the benefits of online learn-ing, including its …

Harmonization And Ambiguity In Regulations For Physicians With Family Medicine Competence Post-Law No. 17 Of 2023, Danar Wahyu Giwang Katon, Dumilah Ayuningtyas, Purnawan Junadi, Wahyu Sulistiadi, Roberth J. Pattiselanno, Fitria Fitria, Ika Fitri Alfiani

Journal of Indonesian Health Policy and Administration

Strengthening primary care services in Indonesia requires that community health centers, namely Pusat Kesehatan Masyarakat (Puskesmas), involve medical personnel with family medicine competence. However, the fulfillment of physicians with this competence, especially Primary Care Family Medicine Specialists or Spesialis Kedokteran Keluarga Layanan Primer (Sp.KKLP), still face significant obstacles. This qualitative research uses the integrated Easton's System Model and Buse's Policy Framework to analyze the dynamics of this policy. The findings reveal a gap between the strong legal foundation and weak implementation mechanisms on the ground. First, there is ambiguity in terminology and lack of harmonization among regulations, especially concerning the …

Ease The Quease! Educating Nurses On Non-Pharmacologic Nausea Intervention, Hawa Abdalla, Hannah Bookout, Leslie Martinez, Sidney Mcgregor, Jillian Norman, Gabriella Tadlock, Lucille Willians

2025

No abstract provided.

Formulaic Sequences: Teacher And Student Perceptions And Teaching Strategies, Ali Sayed Muhammad Abd Allah

Theses and Dissertations

Formulaic Sequences (FS), common word combinations stored and used as single units, are crucial for achieving oral fluency yet remain underrepresented in pedagogical materials. This study explores this gap by examining teacher and student perceptions of FS and the teaching techniques within an online Egyptian EFL context. Utilizing a mixed-methods approach, data were gathered via teacher interviews (n=4), student questionnaires (n=100), a student focus group (n=4), and classroom observations. Results indicated that teachers unanimously perceived FS as essential building blocks for fluency, accuracy, and learner confidence, and they utilized a spectrum of techniques ranging from explicit instruction to incidental exposure …

Keeping It Together: Assessing The Wellbeing Of Project-Based Development Practitioners In Egypt, Amira Ahmed Abdallah Fekry Ahmed

Theses and Dissertations

This thesis examines the wellbeing of project-based development practitioners in Egypt, revealing how systemic pressures—bureaucracy, job insecurity, and fragmented workloads—undermine both wellbeing and productivity. The study employed a mixed-approach, combining 10 in-depth interviews with subject matter experts and practitioners and 75 surveys with development practitioners in Egypt. Data revealed that while many practitioners are driven by purpose, structural challenges erode resilience and motivation over time. Social support networks and personal coping strategies help but cannot replace institutional protections. The study argues that wellbeing must shift from being treated as an individual concern to a structural responsibility. Reframing organizational models around …

The Ai Academic Integrity Dichotomy: A Gender Lens, N. Sayegh, S. Larloulian, A. C. Elias, Leila Halawi

Publications

Using a gender lens, this research explores the intersection of artificial intelligence (AI) educational tools and academic integrity. Studies suggest gender differences exist in academic dishonesty rationalization, with males potentially exhibiting more opportunistic behaviors. This qualitative study collected data through 30-minute face-to-face semi-structured interviews, recorded with consent, and analyzed thematically. Four significant themes emerged: Gender Perspectives on AI Tool Usage, Patterns of AI Tool Utilization, Academic Integrity Concerns, and Implications of Academic Dishonesty. The results indicate that educational establishments should adopt responsible AI governance frameworks and ethical guidelines to uphold academic standards while promoting scholarly integrity and institutional trust.

Design Of Novel Formwork System And Development Of Numerical Model For Comparison Between Formwork Systems, Ahmed Yehia Abdel Aziz El Sayed

Theses and Dissertations

The formwork industry has witnessed major breakthroughs in the last decades. However, they required huge amount of materials leading to negative environmental impacts. Also, the commercially available systems have big number of accessories and requires the extensive use of units to cover the areas to be poured. There was an attempt to target all these disadvantages by introducing the Funicular Arched Steel Truss (FAST) system. However, this system had its own drawbacks, and this is why the researcher introduced an extendable version named the “Extendable Funicular Arched Steel Truss (EAST) system.”

To reach the final version of the EAST design, …

Managing Capacity Development For Administrative Staff In Higher Education Institutions: A Case Study Of The American University In Cairo, Amal Gamal Kaldas

Theses and Dissertations

Capacity development (CD) is a fundamental factor in the success of an organization, particularly in the initiation of higher education (HEIs) where administrative staff have a significant role in operational functions. This thesis presents several aspects that shape the capacity development for administrative staff in higher education institutions and the foundation of theories that relate to CD. Focusing on The American University in Cairo (AUC) as a case study to explore the current CD programs, how the administrative staff perceive the CD programs, and the challenges that hinder AUC in implementing these programs, and how AUC manages these programs. A …

Egypt’S Strategic Hedging In Economics With The United States And China From 2014-2024, Abigail Flynn

Theses and Dissertations

This research aims to explain how Egypt is able to engage economically with two internationally competitive powers, the United States and China, using the theoretical framework of strategic hedging in the period of 2014-2024. While existing literature on strategic hedging is primarily focused on Southeast Asia and broadly deals with political hedging, this study applies the framework specifically to Egypt and is limited to economic relations. This research is significant because it identifies how Egypt is able to increase its economic engagement with the U.S. and China despite their competitive status and offers a novel argument which can be tested …

Social Media And Public Opinion In Times Of Conflict: How Arab Social Media Impacted International Perspectives On The Gaza War, Mariam Rizk

Theses and Dissertations

This exploratory study examines how Arab social media content creators impacted the international public perception of the 2023 Gaza war through English-language content. The research is conducted through semi-structured interviews with 19 participants: 4 Arab social media content creators and 15 English-speaking university students (13 American citizens and 2 international students studying in American universities). Through these semi-structured qualitative interviews, the research investigates the agenda-setting capabilities of social media during conflicts and identifies effective cross-cultural communication strategies. The study employed purposive sampling with snowball technique, targeting content creators with established social media presence (37,000-426,000 Instagram followers) and university students who …

The Association Between Acceptance Of Illness And Quality Of Life Among Rheumatoid Arthritis Patients In Egypt, Terivina Ayad Naguib Ayad

Theses and Dissertations

Rheumatoid arthritis is a common connective tissue autoimmune disease that has multidimensional impact on the patients’ daily functioning and quality of life. Due to the long- lasting incurable nature of RA, psychosocial adaptation to living with it becomes inevitable. Literature indicates that acceptance of illness as an appraisal of the disease and personal attitude towards it is related to better quality of life. The present study aims at investigating the relationship between disease acceptance and quality of life among rheumatoid arthritis patients in Egypt. This study also investigates the association of selected socio-demographic and disease related variables with quality of …

Assessing School Readiness For Social And Emotional Learning: A Study Of School Leadership Perceptions And Attitudes, Nahla Elharati

Theses and Dissertations

This study explores the integration of social and emotional learning (SEL) in a number of British schools across Egypt, focusing on how school leaders defined and perceived its importance in student development. Through in-depth interviews with twelve school leaders, this study found that school leaders’ definitions of SEL emphasized self- awareness, self-regulation, and relationship-building, alongside a strong focus on the real-life applicability of SEL both within school settings and in students’ future lives. School leaders also expressed positive attitudes toward the benefits of SEL, particularly its role in enhancing academic performance, promoting student well-being, improving peer relationships, and reducing bullying, …

Mechanical Characterization And Modeling Of Rat Myocardia Under The Influence Of Epirubicin, Abdallah Mahmoud Alkhaiyat

Theses and Dissertations

Cancer remains a predominant health challenge that is responsible for a significant portion of global morbidity and mortality. Epirubicin (EPI), a chemotherapeutic anti-cancer drug, has shown remarkable efficacy in combating various malignancies. However, it is known to have undesirable side effects on the heart, collectively referred to as cardiotoxicity. This research investigates the adverse effects of chemotherapy on cardiac contractility through an in vitro examination of the mechanics of healthy and infarcted animal heart tissues. Electrically stimulated slices of rat ventricular tissue were tested using an isometric force measurement tissue bath. The tissue slices were subjected to uniaxial stretching, allowing …

Resilience By Design: A Multi-Metric Assessment Of Urban Vulnerability Across Human-Centric, Built, And Climatic Environment Dimensions, Karim Abdelhady

Theses and Dissertations

Urban resilience and sustainability have emerged as fundamental imperatives in contemporary urban planning, as cities face mounting pressures from climate change, population growth, and increasing socio-economic disparities. Resilient urban systems are not only those that withstand shocks, but also those that ensure the long-term well-being, equity, and functionality of their environments. As such, advancing the capacity to systematically evaluate resilience across spatial and temporal scales is critical to informing adaptive, forward-looking planning strategies. Despite a growing body of research on urban resilience, prevailing approaches remain limited in scope and resolution. Many studies tend to examine resilience through isolated lenses—focusing either …

An Impact Assessment Of The Effectiveness Of Utilizing Informal Health Communication Interventions To Spread Health Recommendations And Change Public Perception, Lina Mohamed Ezzat Ahmed Abdel Mawgoud

Theses and Dissertations

Brain health is an increasingly urgent but critically under-addressed public health priority in Egypt and the wider MENA region. Despite its centrality to aging, productivity, and overall quality of life, public understanding of brain health remains limited, and stigma continues to shape responses to dementia and cognitive decline. This study evaluates the effectiveness of informal, culturally adapted health communication as a tool to shift perception, increase awareness, and promote behavior change among non-medically trained adults in Egypt.

Grounded in global evidence on cognitive reserve, neuroplasticity, and the life-course approach to brain health, the intervention translated expert-informed brain health recommendations into …

Electronic Transport In Twisted Bilayer Tungsten Diselenides, Walid Zaher

Theses and Dissertations

This thesis investigates density waves (DWs) in twisted bilayer tungsten diselenide (tWSe₂) using a mean field approximation, with a focus on electron-electron interactions, and the system’s free energy at zero temperature. For the mean field approximation, the study initially employed same-spin nesting vectors, which were found insufficient to induce DWs formation. In contrast, when opposite-spin nesting vectors were used, DWs emerged, indicating that these vectors can support DWs formation. The plots were produced under perfect nesting conditions, where van Hove singularities (VHS) occur. At zero temperature, perfect nesting provides a complete picture of the upper limit of DWs formation, as …

Irrigation Efficiency In Green Wall Systems Utilizing Iot: Developing And Testing A Method To Optimize Water Use For Green Walls, Yomna Zaghloul

Theses and Dissertations

This study investigates the application of an Internet of Things (IoT)-based automated irrigation system for green walls in Cairo, Egypt, assessing its impact on water conservation, energy consumption, and plant health across a three-month experimental period. The research compared a sensor-controlled drip irrigation system utilizing the ESP8266 microcontroller and real-time environmental monitoring against conventional timer-based irrigation methods. Water usage data revealed that the IoT system consistently achieved substantial savings—averaging nearly 60% less water consumption than the control group—without compromising overall plant vitality. Energy efficiency was also improved, with automated cycles reducing pump operating time by more than 50%. Plant growth …

A Virtual-Reality-Based Dental Simulator For Endodontics With Automated Formative Feedback, Yousef Salah Abo El Ela

Theses and Dissertations

Advancements in virtual reality (VR) and haptic technology are transforming the landscape of medical and dental education, offering new avenues for safe, immersive, and repeatable training experiences. Within dentistry, endodontics presents unique challenges for preclinical education due to anatomical complexity, limited access to extracted teeth, ethical concerns, and the shortcomings of conventional plastic models. Despite endodontics specific plastic teeth being available, they fall short of replicating the hardness of real extracted teeth, are relatively costly compared to generic plastic teeth, and are ultimately a disposable item which makes them inadequate as a sustainable long-term solution. Extracted teeth do a much …

Towards Decarbonizing Concrete Industry In Egypt: Material Alternatives, And Economic Viability, Reem Gamal

Theses and Dissertations

The construction industry remains one of the largest contributors to global greenhouse gas emissions, with cement and steel production accounting for approximately 15% of total emissions. As global infrastructure demands continue to rise, there is an increasing need for practical tools that support low-carbon construction practices in line with international climate commitments. This research presents the development and testing of a mathematical, adaptable decision support system designed to assess both the environmental and financial impacts of material selection in concrete production. Focusing on life cycle stages A1 to A3, raw material extraction, transportation, and manufacturing, the decision support system enables …

Advancing Climate Transition Through Fiscal Tools: The Role Of Carbon Taxation And Fuel Subsidy Reform, Farah Amgad Zayed

Theses and Dissertations

This study highlights how fiscal policy tools can accelerate Egypt's climate transition, with emphasis on carbon taxes and fossil fuel subsidies reforms. It investigates how fiscal tools can reduce carbon emissions and promote economic development by primarily relying on qualitative interviews with policymakers, consultants, representatives of the private sector, and civil society actors, paralleled with some descriptive and comparative analysis. The results show that even though Egypt has made significant strides in advancing green transition, including updating the Nationally Determined Contributions (NDC), introducing the first African Voluntary Carbon Market (VCM), as well as phasing out fossil fuel subsidies gradually, institutional …

Stakeholder Views Of Real Estate Registration In Egypt And The Reform Of 2022, Karim Alsisi

Theses and Dissertations

Real estate registration in Egypt has historically remained low despite the enactment of a deeds registration law in the 1940s and a title registration law in the 1960s. The 2022 reform (Law No. 9 of 2022) warranted an assessment of its effectiveness through a Public Policy and Administration lens. This thesis has two main objectives: first, to examine stakeholders’ views of the reform; and second, to explore stakeholder perspectives on formal registration and the factors driving registration avoidance by employing a qualitative design, using in-depth interviews with four stakeholder groups encompassing both system users and service providers. The findings revealed …

Evolving Skills And Stakeholder Dynamics: Investigating The Transformative Influence Of Generative Ai On Egyptian Public Policy, Zeinab Hosny Abdelgawad

Theses and Dissertations

Since its public release in November 2022, OpenAI's Generative AI (GenAI) has been met with varied responses, from widespread individual adoption to institutional caution. This phenomenon is evident among Egyptian public policy makers, where some institutions quickly embraced GenAI, while others have been slow to integrate it. The adoption of GenAI among these professionals is influenced by multiple factors, with institutional factors and budget constraints being the most significant. The varied adoption creates a need for new skills and the enhancement of existing ones. This uneven adoption is hypothesized to cause two main issues in Egyptian public policy: a policy …

Between Borders And Bodies: Sovereignty, Universality, And The Crisis Of Enforcement In International Law, Aliaa Riad Hassanien Aliaa Riad

Theses and Dissertations

Atrocities such as genocide and war crimes persist not despite international law, but within its very structure. Although international law is designed to protect humanity, it repeatedly fails to do so due to its inability to enforce its most fundamental norms. In the absence of enforcement, the law exists—but merely stands still. This failure stems from the structural contradictions embedded in the system—specifically, the tension between the principles of sovereignty and universality. As a result, international law has become a selective, politicized, and ineffective framework. Incidents such as the Rwandan genocide and the civil wars in Syria and Sudan demonstrate …

A Computational Study Of The Chemomechanics Of Paracetamol Polymorphs: Towards Improving Drug Tabletability, Karim Nader Samra

Theses and Dissertations

The mechanical properties of pharmaceutical crystals are of great importance in tablet manufacturing. Also, knowing the mechanical properties of different polymorphs of the same crystal can reduce the overall production cost. In this study, computational work was done via performing density functional theory calculations on 3 paracetamol crystal polymorphs Form I, II, and III. Understanding the chemical bonding helps in predicting the key elastic properties for different crystallographic directions. In Form II, lattice vector C is dominated with the intermolecular hydrogen bond OH…O giving it the stiffest Young Modulus and the least Poisson’s ratio. Then comes the A-Axis which contains …

Family Caregivers And Suicide Prevention: A Needs And Assets Assessment In Egypt, Lina Osama Allam

Theses and Dissertations

In the Arab world, suicide prevention is shaped by cultural stigma and religious beliefs, shaping both help-seeking behaviors and the design of support systems. Family caregivers play a vital role in suicide prevention but often face significant emotional and logistical burdens. This study is the first known scholarly effort in Egypt to examine the intervention needs of these caregivers. It explored three key questions: the roles and challenges of caregivers supporting individuals with suicidal thoughts or behaviors; the availability of clinical and community-based resources; and the characteristics of future interventions to support them. A total of 92 mental health professionals …

Digital Payment Adoption And Firm Performance In Egypt: An Empirical Study From The Digital Transformation Era In Mena, Alhussein M. Mowafi

Theses and Dissertations

This study investigates the relationship between digital payment adoption and firm-level innovation and revenue performance in Egypt, using microdata from the Survey of Enterprise Digitization published by the Economic Research Forum (ERF). Digital transformation, specifically payments, has accelerated across emerging economies, yet empirical evidence on its firm-level impacts in the Middle East and North Africa (MENA) remains limited. The study is framed through the Technology-Environment-Organization (TOE) framework and is highly incorporated with the Solow Growth Model through indirect technological growth inputs in the Solow residual. To address this gap, the study employs probit and ordered logit models to examine whether …