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4e-Bp1 Differentially Regulates Translation Of A Subset Of Human Mrnas, Mehreen Mahbub Feb 2026

4e-Bp1 Differentially Regulates Translation Of A Subset Of Human Mrnas, Mehreen Mahbub

Dissertations, Theses, and Capstone Projects

Elevated levels of eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) influence cap-independent translation by forming a complex with eukaryotic initiation factor 4E (eIF4E) (eIF4E•4E-BP1). Certain mRNAs—including those encoding hypoxia-inducible factor-1α (HIF-1α), fibroblast growth factor-9 (FGF-9), and two isoforms of tumor suppressors, p53 (p53A, and p53B)—contain structured 5’untranslated regions (UTRs) that enable translation either via cap-independent translation enhancer (CITE)-like or internal ribosomal entry site (IRES)-like mechanisms. However, how 4E-BP1 modulates these mechanisms remains unclear. Using fluorescence-based anisotropy assays, we showed that the eIF4E•4E-BP1 binds more tightly to the 5’ m7G-cap of these mRNAs than eIF4E …


Chamber Music For Strings In Rational Intonation: Performance Practice And Analysis, Marina Kifferstein Feb 2026

Chamber Music For Strings In Rational Intonation: Performance Practice And Analysis, Marina Kifferstein

Dissertations, Theses, and Capstone Projects

In the early 21st century, the field of contemporary music has experienced an explosion of interest in rational intonation. This ratio-derived tuning system, often referred to as “just intonation,” has become established as a widespread movement that is still on the rise. It is of increasing importance for composers, performers, historians, and theorists who specialize in contemporary music to be knowledgeable about the growing body of repertoire in this area and its performance practice.

This dissertation examines current and recent trends in rational intonation through the lens of chamber music for strings. It includes perspectives on performance practice gleaned …


Autoconvocadxs: Interpretaciones Biopolíticas Y Psicopolíticas Del Poder Popular, El Archivo Y La Memoria En La Cultura Popular De Puerto Rico, Jose A. Acosta-Seda Feb 2026

Autoconvocadxs: Interpretaciones Biopolíticas Y Psicopolíticas Del Poder Popular, El Archivo Y La Memoria En La Cultura Popular De Puerto Rico, Jose A. Acosta-Seda

Dissertations, Theses, and Capstone Projects

Autoconvocadxs analizan el nacimiento, el desarrollo y la consolidación de la asamblea popular como un mecanismo para fiscalizar la labor del Estado. Este, insuficiente y al servicio de las instituciones imperiales, se ha desentendido de las necesidades del pueblo en momentos de crisis. Al servicio de la agenda imperial estadounidense, el gobierno puertorriqueño echó mano de diversas estrategias de coerción y vigilancia que perjudicaron el desarrollo social, económico y político de Puerto Rico. Sin embargo, dichas estrategias e instrumentos de vigilancia han evolucionado a través del tiempo: desde una perspectiva biopolítica en los años 1970, hasta el triunfo de la …


The Digital Divide In Political Redistricting: Ai's Impact On Minority Representation, Jaime Rodriguez Feb 2026

The Digital Divide In Political Redistricting: Ai's Impact On Minority Representation, Jaime Rodriguez

Dissertations, Theses, and Capstone Projects

Technology plays a significant role in people's daily lives worldwide. It has infiltrated many aspects of our lives, from education and healthcare to politics. With our increasing reliance on technology, artificial intelligence (AI) has become well-enmeshed in our political systems, affecting people everywhere, especially minority groups. This essay will investigate the potential effects of AI on the political influence of racial and ethnic minorities, specifically focusing on its role in altering voting district boundaries— a practice referred to as redistricting. There are several areas of concern under which AI could unintentionally worsen gerrymandering, impact equity in the representation of minority …


I Wear The Past In The Cold, Cecilia Knaub Feb 2026

I Wear The Past In The Cold, Cecilia Knaub

Dissertations, Theses, and Capstone Projects

“I wear the past in the cold” is a multi-modal archival project exploring themes of intergenerational memory and postmemory. A hand-knit sweater acts as an archive, encoded with metadata about a collection of newspaper articles written by my late father, as well as affectual elements of memory and grief. The accompanying website provides additional detail into the project and design choices. The piece builds on work from memory studies, craft studies, digital humanities, and critical data studies to create a tangible and personal archival object. By accepting the invitation from the #DHMakes movement (Visconti, Dombrowski, and Berger 2020) to embrace …


Dumatree: Free Online Education In Bridging The Migrant Digital Divide, Mia Lee Feb 2026

Dumatree: Free Online Education In Bridging The Migrant Digital Divide, Mia Lee

Dissertations, Theses, and Capstone Projects

Research Questions: This capstone project addresses two primary research questions. First, it examines the digital divide within the immigrant-serving non-profit sector, specifically investigating the lack of computer and digital skills training in organizations that serve refugees and migrants. Second, it asks: is it possible to build a scalable, professional-grade tech curriculum using only free, Wi-Fi-accessible online tools? To address the first question, 50 non-profit organizations serving refugees and migrants were reviewed to assess their technical education offerings. To address the second question, Dumatree.com was developed using universally accessible digital resources. A website was the most appropriate format for this project, …


New Fast Polynomial Root-Finders, Soo Go Feb 2026

New Fast Polynomial Root-Finders, Soo Go

Dissertations, Theses, and Capstone Projects

Univariate polynomial root-finding has been studied for four millennia and very intensively in the last decades. Our {\em black box root-finder} involves no coefficients and works for a black box polynomial, defined by an oracle (that is, black box subroutine) for its evaluation. Such root-finders have various benefits, e.g., are particularly efficient where a polynomial can be evaluated fast, say, is a sum of a small number of shifted monomials (x-c)^a.

Our root-finder approximates all d complex zeros of a dth degree polynomial p(x) (aka roots of equation p(x)=0) by using Las Vegas expected number of bit-operations within a factor …


The Constant Cause Of Friction: Maud Mosher And Gendered Authority In The Indian Service And At Ellis Island, Ella Morton Feb 2026

The Constant Cause Of Friction: Maud Mosher And Gendered Authority In The Indian Service And At Ellis Island, Ella Morton

Dissertations, Theses, and Capstone Projects

This thesis focuses on the federal career of Maud Mosher, who, from 1893 to 1907, worked as an Indian Service boarding-school teacher, then a matron at Ellis Island. By analyzing Mosher’s extensive, complaint-driven correspondence and personnel files, as well as an unpublished memoir, I claim that her grievances represent a rare form of agency available to women in maternalist roles at Progressive Era federal agencies. Though Mosher’s superiors branded her complaints trivial, the substance of them reveals gendered hypocrisy and institutional contradictions inside two federal institutions dealing with racialized populations.

In both the Indian Service and the Immigration Service, Mosher …


Sometimes I Picture You Dreaming: How American Female Directors Use Women-In-Prison Films As A Pathway For Public Education And Activism In The Era Of Mass Incarceration, Nicolette Natale Feb 2026

Sometimes I Picture You Dreaming: How American Female Directors Use Women-In-Prison Films As A Pathway For Public Education And Activism In The Era Of Mass Incarceration, Nicolette Natale

Dissertations, Theses, and Capstone Projects

This thesis examines the role of female directors in creating media that showcases how prisons perpetuate sexism or gender-based violence. As mass incarceration began to take off in the 1970s, this paper begins with an analysis of Jack Hill’s The Big Doll House (1971), which often served as the model for women-in-prison (WIP) exploitation films. While Hill perpetuated the white and male gaze in The Big Doll House, Stephanie Rothman subverts oppressive gazes in her WIP film, Terminal Island (1973), and demonstrates a concern with the historical gendered realities of prison – moving beyond representations of prison on the …


Development Of Novel Anti-Cancer Colchicine Analogs: Synthesis And Configurational Studies, Orugbani S. Eli Feb 2026

Development Of Novel Anti-Cancer Colchicine Analogs: Synthesis And Configurational Studies, Orugbani S. Eli

Dissertations, Theses, and Capstone Projects

Colchicine, a naturally occurring alkaloid, has long been known as a potent therapeutic agent. Despite its efficacy treating gout and other inflammatory disorders, its severe toxicity, limited selectivity, and poor pharmacological profile have restricted its broader clinical application. Reported advantages of colchicine-site ligands as vascular-disrupting agents, including reduced susceptibility to multidrug resistance, have revived interest in the colchicine site on tubulin as a validated therapeutic target for cancer. This dissertation focuses on the development of new colchicine analogs, detailing the synthetic method to functionalized AC-ring derivatives, as well as the evaluation of their configurational stability and biological activity.

In Chapter …


Social Capital And The Spread Of Information On Twitter Related To Change In The Criminal Legal System, Sebastian Hoyos-Torres Feb 2026

Social Capital And The Spread Of Information On Twitter Related To Change In The Criminal Legal System, Sebastian Hoyos-Torres

Dissertations, Theses, and Capstone Projects

Criminal legal reformers and abolitionists have differing visions for change within the criminal legal system, where reformers seek to modify and abolitionists aim to dismantle it altogether (Davis 2005; Foucault 1977; Kaba 2020). Advocates used print media to disseminate information related to their proposed changes to broader audiences. While print media remains a valuable tool to reach wide audiences, the advent of social media introduced new mechanisms to interact with broad audiences at very low cost while leaving traces of digital data which could be analyzed to better understand the social factors which impact whether information is spread. Throughout this …


The Behavior And Complexation Of Technetium Under Conditions Relevant For Nuclear Fuel Reprocessing, Rachel E. Greenberg Feb 2026

The Behavior And Complexation Of Technetium Under Conditions Relevant For Nuclear Fuel Reprocessing, Rachel E. Greenberg

Dissertations, Theses, and Capstone Projects

Spent nuclear fuel is reprocessed by utilizing several large-scale solvent extraction processes. One of the most prevalent of these processes is the plutonium uranium reduction extraction (PUREX) process. This process involves an organic phase composed of tributyl phosphate (TBP) in kerosene and an aqueous phase comprised of concentrated nitric acid. Both uranium (U) and plutonium (Pu) are extracted into the organic phase by nitrate and TBP complexation while the various fission products remain in the initial aqueous phase. Pu is then chemically reduced to its trivalent state and back-extracted into a second aqueous phase, thereby separating the two fissile materials. …


A Work On/Of Language: Lyric And The Care Of The Self, Evan M. Knight Feb 2026

A Work On/Of Language: Lyric And The Care Of The Self, Evan M. Knight

Dissertations, Theses, and Capstone Projects

Drawing on Michel Foucault’s work on the Ancient Greek practice of the care of the self, this dissertation argues that lyric poetry is a technology of the self: an ethical practice that creates potential for self-transformation through the demands it places on language and modes of attention. Lyric thus maintains a form of truth discourse overshadowed by the Cartesian conception of truth as propositional and method-driven. Unlike contemporary self-care, the care of the self, as the original Greek epimeleia heautou entails, is care inflected by concern and anxiety: the practicing subject places her thoughts, assumptions, ways of being, and—in the …


Somatosensory Cortex Responses To Illusory Touch In A Visual-Tactile Integration Task, Aditi Surendra Pawar Feb 2026

Somatosensory Cortex Responses To Illusory Touch In A Visual-Tactile Integration Task, Aditi Surendra Pawar

Dissertations, Theses, and Capstone Projects

Perceptual illusions arising from multisensory integration reveal how the brain constructs subjective experience from sensory input, and provide a powerful means of allowing the investigation of neural processes that track perceptual interpretation rather than physical stimulation alone. While visual illusions induced by auditory or tactile stimuli have been fairly well studied, the neural mechanisms underlying visually-induced illusory touch remain unclear. This study investigated whether illusory tactile perception engages the somatosensory cortex in a manner similar to veridical touch. Twenty healthy adults participated in an event-related functional magnetic resonance imaging (fMRI) study while performing a tactile numerosity judgment task. Each trial …


Filling The Gaps: Maiti Nepal And Anti-Trafficking Governance In Nepal, Sushmita Lamsal Feb 2026

Filling The Gaps: Maiti Nepal And Anti-Trafficking Governance In Nepal, Sushmita Lamsal

Dissertations, Theses, and Capstone Projects

Human trafficking in Nepal is closely linked to labor migration, gender inequality, and weak state capacity. In this context, non-governmental organizations play a key role in anti-trafficking efforts. This capstone project examines Maiti Nepal’s approach to prevention, rescue, and rehabilitation, with focus on its work at border points and internal facilities provided to human trafficking victims. The study analyzes how Maiti Nepal functions as a quasi-state actor by addressing gaps in Nepal’s anti-trafficking framework, highlights challenges associated with limited inconsistent funding, uneven resource distribution, and support for survivors. The study argues that Maiti Nepal’s significance lies not only in its …


Foreign Songs, Occitan Voices, And The Guitar In Early Modern France (C. 1570-1650), Ana Beatriz Mujica Lafuente Feb 2026

Foreign Songs, Occitan Voices, And The Guitar In Early Modern France (C. 1570-1650), Ana Beatriz Mujica Lafuente

Dissertations, Theses, and Capstone Projects

The cultural traditions of European nations are too often treated as independent and essential entities, obscuring the transnational and interregional exchanges that have shaped modern cultures. In musicology, recent studies have emphasized the plurality and mobility of people, cultures, and music in Europe. Yet, French songs are still largely explained within the framework of the national, generally privileging written over oral traditions, printed over manuscript music, national over regional languages, and monolingual over plurilingual practices. Through the study of songs in Italian, Spanish, Occitan, and Turkish, this dissertation challenges such preconceptions.

This study shows that secular songs in foreign and …


Markvcid2 Consortium For Clinical Validation Of Biomarkers Of Cerebral Small Vessel Disease: Validation Framework And Baseline Characteristics, Steven M Greenberg, Marylin S Albert, Hongyu An, Konstantinos Arfanakis, Arnold M Evia, Arvind Caprihan, Andria L Ford, Myriam Fornage, Gregory S Day, Jason D Hinman, Gregory A Jicha, Amir H Kashani, Joel H Kramer, Christian Lachner, Jin-Moo Lee, Peiying Liu, Hanzhang Lu, Pauline Maillard, Ronald C Petersen, Bruce M Psaty, John M Ringman, Gary A Rosenberg, Claudia L Satizabal, Sean I Savitz, Julie A Schneider, Sudha Seshadri, Prashanthi Vemuri, Danny J J Wang, Donna M Wilcock, B Gwen Windham, Rong Zhang, Carissa Tuozzo, Herpreet Singh, Sue Moy, Vilma Okey-Ewurum, Courtney B Page, Hillary Mulder, Pia Kivisäkk, Deborah Blacker, Lidiya Mazina, Karl G Helmer, Kristin Schwab, Lisa M Wruck, Roderick A Corriveau Feb 2026

Markvcid2 Consortium For Clinical Validation Of Biomarkers Of Cerebral Small Vessel Disease: Validation Framework And Baseline Characteristics, Steven M Greenberg, Marylin S Albert, Hongyu An, Konstantinos Arfanakis, Arnold M Evia, Arvind Caprihan, Andria L Ford, Myriam Fornage, Gregory S Day, Jason D Hinman, Gregory A Jicha, Amir H Kashani, Joel H Kramer, Christian Lachner, Jin-Moo Lee, Peiying Liu, Hanzhang Lu, Pauline Maillard, Ronald C Petersen, Bruce M Psaty, John M Ringman, Gary A Rosenberg, Claudia L Satizabal, Sean I Savitz, Julie A Schneider, Sudha Seshadri, Prashanthi Vemuri, Danny J J Wang, Donna M Wilcock, B Gwen Windham, Rong Zhang, Carissa Tuozzo, Herpreet Singh, Sue Moy, Vilma Okey-Ewurum, Courtney B Page, Hillary Mulder, Pia Kivisäkk, Deborah Blacker, Lidiya Mazina, Karl G Helmer, Kristin Schwab, Lisa M Wruck, Roderick A Corriveau

Faculty, Staff and Student Publications

Objective: To establish a framework for validating candidate biomarkers of cerebral small vessel diseases (SVD) associated with cognitive impairment and characterize individuals enrolled by the MarkVCID2 consortium under this framework.

Methods: Participants age 60 to 90 years were enrolled across 17 MarkVCID2 sites. Recruitment was targeted to enrich in cognitive symptoms (mild dementia, mild cognitive impairment, subjective cognitive decline), defined risk factors (diabetes mellitus, advanced hypertension), and Black/African American, White, and Hispanic/Latino subgroups. Enrolled participants underwent baseline visits that included cognitive testing, multimodal magnetic resonance imaging (MRI), and biofluid collection. Provisional risk for SVD-related cognitive decline was estimated primarily by …


Outcomes Of Witnessed Versus Unwitnessed Patients With Stroke After Endovascular Therapy In The Extended Time Window, Liisa Tomppo, Nicolas Martinez-Majander, Muhammad M Qureshi, Thanh N Nguyen, Raul G Nogueira, Simon Nagel, Jelle Demeestere, Volker Puetz, Hilde Henon, Marta Olive-Gadea, João Pedro Marto, Anne Dusart, Peter A Ringleb, Osama O Zaidat, Diogo C Haussen, Mahmoud H Mohammaden, Mohamad Abdalkader, Jean Raymond, Santiago Ortega-Gutierrez, Sunil A Sheth, Hiroshi Yamagami, João Nuno Ramos, Francois Caparros, Daniel P O Kaiser, Marc Ribo, Sergio Salazar-Marioni, Kanta Tanaka, Pekka Virtanen, Ajit S Puri, James E Siegler, Syed F Zaidi, Mouhammad Jumaa, Eugene Lin, Jordi Mayol, Rita Ventura, Simon Winzer, Piers Klein, Flavio Bellante, Jorge Cespedes, Anke Wouters, Hesham E Masoud, Liqi Shu, Alicia C Castonguay, Christian Herweh, Monica Cheng, Wei Hu, Daniel Roy, Shadi Yaghi, Robin Lemmens, Charlotte Cordonnier, Markus A Möhlenbruch, Daniel Strbian Feb 2026

Outcomes Of Witnessed Versus Unwitnessed Patients With Stroke After Endovascular Therapy In The Extended Time Window, Liisa Tomppo, Nicolas Martinez-Majander, Muhammad M Qureshi, Thanh N Nguyen, Raul G Nogueira, Simon Nagel, Jelle Demeestere, Volker Puetz, Hilde Henon, Marta Olive-Gadea, João Pedro Marto, Anne Dusart, Peter A Ringleb, Osama O Zaidat, Diogo C Haussen, Mahmoud H Mohammaden, Mohamad Abdalkader, Jean Raymond, Santiago Ortega-Gutierrez, Sunil A Sheth, Hiroshi Yamagami, João Nuno Ramos, Francois Caparros, Daniel P O Kaiser, Marc Ribo, Sergio Salazar-Marioni, Kanta Tanaka, Pekka Virtanen, Ajit S Puri, James E Siegler, Syed F Zaidi, Mouhammad Jumaa, Eugene Lin, Jordi Mayol, Rita Ventura, Simon Winzer, Piers Klein, Flavio Bellante, Jorge Cespedes, Anke Wouters, Hesham E Masoud, Liqi Shu, Alicia C Castonguay, Christian Herweh, Monica Cheng, Wei Hu, Daniel Roy, Shadi Yaghi, Robin Lemmens, Charlotte Cordonnier, Markus A Möhlenbruch, Daniel Strbian

Faculty, Staff and Student Publications

Background: It remains unclear whether outcomes of patients treated with endovascular thrombectomy with large-vessel occlusion and unwitnessed onset of stroke differ from those with witnessed onset in the extended time window.

Methods: We enrolled patients with anterior circulation large-vessel occlusion (internal carotid artery, M1, or M2 segment of the middle cerebral artery) undergoing endovascular thrombectomy within 6 to 24 hours from the time last seen well, from 2014 to 2022, at 66 sites in Europe, North America, and Asia. Patients with a prestroke modified Rankin Scale score of >3 or age < 18 were excluded. We categorized patients by onset mode as witnessed or unwitnessed. The primary outcome was the modified Rankin Scale shift at 90 days. Secondary outcomes were functional independence, a composite of functional independence or return of Rankin to prestroke level, symptomatic intracranial hemorrhage, mortality, and a composite of severe disability or mortality at 90 days. We applied inverse probability of treatment weighting to compare outcomes between the groups.

Results: Of 5098 patients assessed for eligibility, we included …


Uterine Tachysystole And Associated Outcomes: A Systematic Review And Meta-Analysis, Fabrizio Zullo, Benedetta Licitra, Nandini Raghuraman, Alison G Cahill, Aaron W Roberts, Stephanie Roth, Daniele Di Mascio, Antonella Giancotti, Giuseppe Rizzo, Kristen A Cagino, Hector Mendez-Figueroa, Anthony C Sciscione, Suneet P Chauhan Feb 2026

Uterine Tachysystole And Associated Outcomes: A Systematic Review And Meta-Analysis, Fabrizio Zullo, Benedetta Licitra, Nandini Raghuraman, Alison G Cahill, Aaron W Roberts, Stephanie Roth, Daniele Di Mascio, Antonella Giancotti, Giuseppe Rizzo, Kristen A Cagino, Hector Mendez-Figueroa, Anthony C Sciscione, Suneet P Chauhan

Faculty, Staff and Student Publications

Objective: To determine whether uterine tachysystole is associated with adverse neonatal and maternal outcomes.

Data sources: A search strategy for PubMed (National Library of Medicine) was created, and the medical librarian translated the search for every database. The search strategy was peer reviewed by another medical librarian following the Peer Review of Electronic Search Strategies checklist. The databases included in this search were PubMed, Embase.com, Cochrane CENTRAL, CINAHL Ultimate, and Scopus; a combination of key words and subject headings was used.

Methods of study selection: Trials of nulliparous or multiparous parturients exposed to uterine tachysystole were included. Included studies compared …


Sleep-Disordered Breathing In Newborns After Myelomeningocele Repair, Renée A Shellhaas, Fauziya Hassan, Thornton A Mason, Jagruti Anadkat, Ellen Bendel-Stenzel, Stephanie Eyerly-Webb, Cindy K Jon, Robin M Lloyd, Julie S Moldenhauer, Ramesha Papanna, John E Pascoe, Stefanie Riddle, Regina Reynolds, Brandon G Rocque, Narong Simakajornboon, Marjorie C Treadwell, R Bradley Troxler, Lydia S Youmans, Niko A Kaciroti, Harlan Mccaffery, Hemant A Parmar, Lora Merley, Stephanie Md Rau, Ronald D Chervin, John D E Barks Feb 2026

Sleep-Disordered Breathing In Newborns After Myelomeningocele Repair, Renée A Shellhaas, Fauziya Hassan, Thornton A Mason, Jagruti Anadkat, Ellen Bendel-Stenzel, Stephanie Eyerly-Webb, Cindy K Jon, Robin M Lloyd, Julie S Moldenhauer, Ramesha Papanna, John E Pascoe, Stefanie Riddle, Regina Reynolds, Brandon G Rocque, Narong Simakajornboon, Marjorie C Treadwell, R Bradley Troxler, Lydia S Youmans, Niko A Kaciroti, Harlan Mccaffery, Hemant A Parmar, Lora Merley, Stephanie Md Rau, Ronald D Chervin, John D E Barks

Faculty, Staff and Student Publications

Background & objective: Sleep-disordered breathing (SDB) may be a remediable contributor to abnormal cognitive outcomes for children with myelomeningocele. We investigated the frequency of SDB among neonates with fetal vs postnatal myelomeningocele repair.

Methods: In this nine-center, prospective, observational study, neonates with myelomeningocele born at more than 30 weeks gestational age underwent a 10-hour bedside polysomnogram at at least 35 weeks postmenstrual age, before hospital discharge. The primary outcome was SDB severity, reflected by the apnea-hypopnea index (AHI; number of respiratory events per hour of sleep). Decisions regarding surgical timing (fetal vs postnatal), technique (open fetal vs fetoscopic approach), and …


Association Of Intended Mode Of Delivery With Neonatal And Maternal Outcomes At 22-25 Weeks Of Gestation, Jameaka L Hamilton, Paula L Mcgee, Baha M Sibai, Michael W Varner, Alan T N Tita, Monica Longo, Edward F Bell, Barbara J Stoll, John M Thorp, Uma M Reddy, Heather A Frey, Emily S Miller, Dwight J Rouse, Hyagriv N Simhan, Jennifer L Bailit, Lorraine Dugoff, George R Saade Feb 2026

Association Of Intended Mode Of Delivery With Neonatal And Maternal Outcomes At 22-25 Weeks Of Gestation, Jameaka L Hamilton, Paula L Mcgee, Baha M Sibai, Michael W Varner, Alan T N Tita, Monica Longo, Edward F Bell, Barbara J Stoll, John M Thorp, Uma M Reddy, Heather A Frey, Emily S Miller, Dwight J Rouse, Hyagriv N Simhan, Jennifer L Bailit, Lorraine Dugoff, George R Saade

Faculty, Staff and Student Publications

Objective: To compare the risk of neonatal and maternal morbidity and mortality among individuals who delivered between 22 and 25 weeks of gestation by intended mode of delivery.

Methods: This was a secondary analysis of an observational cohort including participants with a singleton pregnancy delivered by planned cesarean delivery or after a trial of labor from 22 0/7 to 25 6/7 weeks of gestation. This analysis was limited to those who received both antenatal steroids and neonatal resuscitation. The primary outcome was a composite of neonatal death or severe neonatal morbidity. Secondary outcomes included neonatal mortality and measures of neonatal …


Bayesian Posthoc Trial Analysis Of Cerclage Management In Preterm Prelabor Rupture Of The Membranes, Beth L Pineles, Kyung Hyun Lee, Baha M Sibai Feb 2026

Bayesian Posthoc Trial Analysis Of Cerclage Management In Preterm Prelabor Rupture Of The Membranes, Beth L Pineles, Kyung Hyun Lee, Baha M Sibai

Faculty, Staff and Student Publications

Background: There is inadequate evidence on whether to retain or remove a cervical cerclage after preterm prelabor rupture of the membranes (PPROM). The PROMCerclage trial was the only study to randomize patients to cerclage retention or immediate cerclage removal after PPROM. The trial was terminated early, and results were not statistically significant but the cerclage retention group had shorter latency and more chorioamnionitis. Bayesian post-hoc trial analysis maximizes available clinical trial data by formally integrating information from preexisting studies or prior beliefs into statistical modeling to estimate the probability of a treatment effect.

Objective: To re-analyze published results of the …


The Long-Term Effectiveness Of The Anti-Obesity Medication Phentermine (Leap) Trial: Rationale, Design, And Baseline Characteristics, Caroline Blackwell Young, Emily Rives, Kimberly A Gudzune, Byron C Jaeger, Courtney G Simmons, Brian N White, Stephanie A Hooker, Deborah B Horn, Deborah R Young, Jennifer Vesely, Amanda Velazquez, Catherine Price, Shelly D Cook, Katy Martin-Fernandez, Galina Inzhakova, Nicholas M Pajewski, Jamy D Ard, Kristina H Lewis Feb 2026

The Long-Term Effectiveness Of The Anti-Obesity Medication Phentermine (Leap) Trial: Rationale, Design, And Baseline Characteristics, Caroline Blackwell Young, Emily Rives, Kimberly A Gudzune, Byron C Jaeger, Courtney G Simmons, Brian N White, Stephanie A Hooker, Deborah B Horn, Deborah R Young, Jennifer Vesely, Amanda Velazquez, Catherine Price, Shelly D Cook, Katy Martin-Fernandez, Galina Inzhakova, Nicholas M Pajewski, Jamy D Ard, Kristina H Lewis

Faculty, Staff and Student Publications

Background: Current clinical practice guidelines support the long-term use of pharmacotherapy for obesity treatment. Historically, phentermine has been one of the most prescribed obesity medications (OMs), however, its long-term efficacy and safety have never been evaluated in a randomized trial as its market approval predates such requirements. Here we describe the design, rationale, and baseline characteristics for a 24-month, double-blind, randomized controlled trial evaluating the efficacy, cardiovascular risk, and safety of phentermine in adults with overweight or obesity.

Methods: This multicenter trial will compare outcomes among participants randomized to phentermine 24 mg daily versus placebo for 24 months. All participants …


Cardiometabolic Parameter Change By Weight Regain On Tirzepatide Withdrawal In Adults With Obesity: A Post Hoc Analysis Of The Surmount-4 Trial, Deborah B Horn, Bruno Linetzky, Melanie J Davies, Luke J Laffin, Hui Wang, Madhumita A Murphy, Sarah Zimner-Rapuch, Eva Lau, Avigdor D Arad, Clare J Lee Feb 2026

Cardiometabolic Parameter Change By Weight Regain On Tirzepatide Withdrawal In Adults With Obesity: A Post Hoc Analysis Of The Surmount-4 Trial, Deborah B Horn, Bruno Linetzky, Melanie J Davies, Luke J Laffin, Hui Wang, Madhumita A Murphy, Sarah Zimner-Rapuch, Eva Lau, Avigdor D Arad, Clare J Lee

Faculty, Staff and Student Publications

Importance: In the SURMOUNT-4 trial, most adults with obesity who had tirzepatide withdrawn following a 36-week treatment regained weight. The association between the degree of weight regain and cardiometabolic parameters after tirzepatide withdrawal is unknown.

Objective: To assess changes in cardiometabolic parameters by degree of weight regain after withdrawal of tirzepatide.

Design, setting, and participants: This post hoc analysis of the SURMOUNT-4 trial included tirzepatide-treated participants with 10% or greater weight reduction at week 36 initially randomized to placebo. Data were collected from March 2021 to May 2023, and data were analyzed from February 2024 to March 2025.

Interventions: After …


Preliminary In Vivo Evaluation Of Coracoclavicular Ligament Mechanics During Shoulder Elevation After Acromioclavicular Joint Reconstruction, Jason Konrath, Sydney Wheaton, Alonso Figueroa, James Gregory, Payam Zandiyeh Feb 2026

Preliminary In Vivo Evaluation Of Coracoclavicular Ligament Mechanics During Shoulder Elevation After Acromioclavicular Joint Reconstruction, Jason Konrath, Sydney Wheaton, Alonso Figueroa, James Gregory, Payam Zandiyeh

Faculty, Staff and Student Publications

Background: Persistent instability and altered scapular mechanics after acromioclavicular joint (ACJ) reconstruction may stem from inadequate replication of native coracoclavicular (CC) ligament function. However, in vivo data on postoperative CC ligament behavior during dynamic shoulder motion remain lacking.

Purpose: To assess in vivo functional distance and timing characteristics of the conoid and trapezoid ligaments during active shoulder elevation after ACJ reconstruction, using dynamic stereo x-ray (DSX) imaging and patient-specific 3-dimensional (3D) models.

Study design: Cross-sectional study; Level of evidence, 3.

Methods: Twelve participants (10 men and 2 women, mean age 39 ± 10 years, mean body mass 92 ± 17 …


Fbi National Stolen Art File: Lost Artifacts And Missing Data, Allison N. Arnold Feb 2026

Fbi National Stolen Art File: Lost Artifacts And Missing Data, Allison N. Arnold

Dissertations, Theses, and Capstone Projects

This data exploration project studies the FBI’s National Stolen Art File (NSAF). The NSAF is a repository for information on stolen artistic and cultural objects. By design, the objects in the NSAF should have distinguishing features and some monetary value, with a present minimum of $5,000 USD. As a public awareness tool, the objects in the NSAF should have a reasonable chance of being identified and potentially restituted in the future.

Using object data taken from the NSAF on August 25, 2024, my data exploration work includes a narrative of the data preparation process and a series of data visualizations. …


Development Of The Active Participle Denoting Ongoing Aspect In Heritage Speakers Of Levantine Arabic In The Us, Reem Kanjawi-Faraj Feb 2026

Development Of The Active Participle Denoting Ongoing Aspect In Heritage Speakers Of Levantine Arabic In The Us, Reem Kanjawi-Faraj

Dissertations, Theses, and Capstone Projects

This study investigated the acquisition, development, and productivity of اسم الفاعل “ism il-fA؟el”, Active Participle (AP) when denoting ongoing aspect in the comprehension and production of heritage speakers (HSs) of Levantine Arabic (LA[1]).  Ongoing aspect is mainly realized in Arabic by an inflected imperfective verb preceded by a progressive particle (PROG.V) and in certain cases b AP. Our study is comprised of four sub-studies: a Syrian Levantine Arabic (SLA) adult corpus analysis (production of PROG.V and AP/ CACeC template); a cross-sectional LA child heritage comprehension and production experiment (PROG.V and AP/ CACeC template) ; a longitudinal study of …


No Tech For Apartheid Memory: Oral Histories Of Google Worker Organizing, Zelda Montes Feb 2026

No Tech For Apartheid Memory: Oral Histories Of Google Worker Organizing, Zelda Montes

Dissertations, Theses, and Capstone Projects

The NOTA Google NYC Digital Memory Archive is a digital memory project centering the worker narrative in tech labor struggles in the wake of the ongoing genocide of the Palestinian people. Rooted in my dual experiences as a Google Software Engineer and a No Tech for Apartheid organizer, this capstone project, initially created in 2024, seeks to combat the silencing around the nature of labor organizing through expanding upon the existing archive to incorporate oral history testimonies of NOTA organizers (notechforapartheidmemory.com/interviews). After conducting 4 oral history interviews with former Google workers currently based in NYC, the videos were …


Towards Unbordered Worlds: Mutual Aid Amid Border Internalisation In New York City, Holly Maclean Feb 2026

Towards Unbordered Worlds: Mutual Aid Amid Border Internalisation In New York City, Holly Maclean

Dissertations, Theses, and Capstone Projects

This study explores the relationship between mutual aid and border regimes through the case of Tompkins Distro, a mutual aid group that organises a weekly food distribution in the East Village of New York City. It focuses specifically on two forms of border internalisation that have shaped the emergence and context of Tompkins Distro: welfare state bordering and interior border enforcement. Drawing on four months of participant observations, interviews with core organisers, and documentary analysis, the study examines how Tompkins Distro meets people’s needs each week through a framework of collective care that actively rejects border logics of deservingness and …


Build, Freeze, Expedite, Renew: Messages On Housing In The 2025 New York City Mayoral Campaign, Elizabeth A. Foley Feb 2026

Build, Freeze, Expedite, Renew: Messages On Housing In The 2025 New York City Mayoral Campaign, Elizabeth A. Foley

Dissertations, Theses, and Capstone Projects

Polls of likely voters prior to New York City’s 2025 mayoral race suggested that proposing a persuasive solution to the city’s housing crisis was likely to be critical to the building of a winning electoral coalition. And an important factor in voters’ reception of each candidate’s housing proposals would be the role that housing developers are perceived to play in those solutions. Developers, who are widely regarded as unscrupulous profiteers in a local housing landscape where the deck is always already stacked against the renter or home buyer, figure (accurately or not) as the chief villain in the story many …