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Articles 91951 - 91980 of 5207438
Full-Text Articles in Entire DC Network
Fiscal Year 2024 Fhwa-536 Report For The Kentucky Transportation Cabinet, Doug Kreis, Candice Wallace, Bryan Gibson, Sarah Mccormack
Fiscal Year 2024 Fhwa-536 Report For The Kentucky Transportation Cabinet, Doug Kreis, Candice Wallace, Bryan Gibson, Sarah Mccormack
Kentucky Transportation Center Research Report
Every other year, the Federal Highway Administration (FHWA) requires that states submit a Local Highway Finance Report (FHWA-536) to the agency. This report summarizes data on local highway finances and is used by FHWA to evaluate relationships between and changes in revenues, expenditures and investment patterns, and financial trends. This report presents information submitted by Kentucky in its fiscal year (FY) 2024 FHWA-536. Total receipts from local, state, and federal sources used for road and street infrastructure equaled approximately $1.27 billion. Local sources of funding accounted for the largest share of total receipts (50%), followed by state government sources (41%), …
Kytc Digital Project Delivery Phase 1 Summary, Rachel Catchings
Kytc Digital Project Delivery Phase 1 Summary, Rachel Catchings
Kentucky Transportation Center Research Report
The Kentucky Transportation Cabinet (KYTC) launched its Digital Project Delivery (DPD) Initiative in September 2020 with the goal of expanding the use of digitally formatted plan and project information throughout the transportation asset life cycle, from project delivery through asset management. KYTC retained Kentucky Transportation Center (KTC) staff with expertise in construction and design to facilitate DPD implementation. This document summarizes DPD-related efforts undertaken by the Cabinet over the past five years. Key activities completed during this period include a survey of Kentucky Association of Highway Contractors members to document their perspectives on design file usage and preferences, coordinating multiple …
The Asymmetric Effects Of Posting An Online Review On Future Spending And The Dark Side Of Solicitations, Hulya Karaman
The Asymmetric Effects Of Posting An Online Review On Future Spending And The Dark Side Of Solicitations, Hulya Karaman
Research Collection Lee Kong Chian School Of Business
Motivated by the prevalence of online review creation and solicitation, this paper examines whether posting an online review impacts the reviewer’s future spending on the reviewed brand. Identifying the causal effects of posting an online review is challenging because reviewers self-select into posting, making it an endogenous decision. I overcome this challenge by using randomized online review solicitations as an instrument for the endogenous treatment variable of posting an online review and establish that doing so decreases the average future spending by the reviewers on the reviewed brand. Additionally, I show that soliciting customers to post increases their propensity to …
Old Signals, New Era: Reconsidering How Customer Satisfaction And Employee Satisfaction Impact Shareholder Wealth, Cesar Zamudio, Suyun Mah, Vanitha Swaminathan
Old Signals, New Era: Reconsidering How Customer Satisfaction And Employee Satisfaction Impact Shareholder Wealth, Cesar Zamudio, Suyun Mah, Vanitha Swaminathan
Research Collection Lee Kong Chian School Of Business
Extant research suggests that higher levels of customer and employee satisfaction signal a firm’s competitive advantage, resulting in greater firm value. This article advances the understanding of how firms can manage customer satisfaction and employee satisfaction to increase shareholder wealth in a new environment due to the emergence of social media and a new class of retail investors. Drawing from stakeholder theory and signaling theory, we argue that inconsistency in customer satisfaction and employee satisfaction can be informative to investors and lead to greater shareholder wealth in such a new environment. Our findings demonstrate that there is a negative joint …
Acute Otitis Media: Antibiotic Length, Children's Mercy Kansas City
Acute Otitis Media: Antibiotic Length, Children's Mercy Kansas City
Clinical Critically Appraised Topics
No abstract provided.
Optical Fiber Sensors Using Vernier Effect In Cascaded Fiber Interferometers, Zhouchen Wang
Optical Fiber Sensors Using Vernier Effect In Cascaded Fiber Interferometers, Zhouchen Wang
Dissertations
The optical Vernier effect has emerged as a powerful tool to enhance the sensitivity of optical fiber interferometer-based sensors, opening new opportunities for developing highly sensitive fiber sensing systems. Optical fiber interferometric sensors based on the Vernier effect are widely used for various applications due to their ultra-compact size, high sensitivity, immunity to electromagnetic interference, electrical isolation, resistance to harsh environments, flexibility, multiplexing capability, and remote operation. The aim of this doctoral thesis was to gain a deeper fundamental understanding of the Vernier effect in optical fiber structures and to develop and investigate a series of novel Vernier effect optical …
Stimuli-Responsive Chemotherapy For Glioblastoma: Sequence-Dependent Synergy Of Cold Atmospheric Plasma And Ultrasound With Cationic Lipo-Doxo, Alessandro Cazzolla
Stimuli-Responsive Chemotherapy For Glioblastoma: Sequence-Dependent Synergy Of Cold Atmospheric Plasma And Ultrasound With Cationic Lipo-Doxo, Alessandro Cazzolla
Theses
Glioblastoma (GBM) is an aggressive, infiltrative astrocytic tumour in which pharmacotherapy remains constrained by the blood-brain barrier (BBB) and the heterogeneously altered blood brain tumour barrier, with additional limitations imposed by active efflux and the complexity of the tumour microenvironment. In this setting, externally addressable strategies that modulate transport and uptake at the site of disease are required. A stimuli-responsive chemotherapy platform was developed in which Lipo-DOXO was combined with two non-invasive physical modalities, low-frequency ultrasound (US) and cold atmospheric plasma (CAP), to enhance intratumoural delivery while limiting off-target effects. Liposomes were produced by thin-film hydration followed by a controlled, …
Roadmap To Implement Statewide Veterans Coordinated Care In New Mexico, Nosa Akol, Zachary Bridgewater, Vincent Delsignore, Emily Graham, Mary Rachel Keville
Roadmap To Implement Statewide Veterans Coordinated Care In New Mexico, Nosa Akol, Zachary Bridgewater, Vincent Delsignore, Emily Graham, Mary Rachel Keville
Institute for Veterans and Military Families
The New Mexico State Legislature is interested in building a statewide coordinated care network to better connect veterans and their families to service. This document translates community input into an actionable roadmap for implementation. This outlines key activities, objectives, and milestones across each phase of the project--designed to guide state leaders and implementation partners from design to launch to steady state operations.
Market Culture And Innovation Acceptance In Fire Safety Products: The Moderating Role Of Perceived Market Regulation, Xu Zhang
Dissertations and Theses Collection (Open Access)
Against the backdrop of continuously rising global fire safety standards and ongoing technological iteration in fire protection products, whether innovative fire protection products can be effectively accepted by the market has become a critical issue influencing the returns on firms’ innovation investments and the high-quality development of the industry. Existing studies have predominantly explored innovation diffusion mechanisms from the perspectives of technological attributes or organizational factors, while paying relatively limited attention to market culture as a contextual factor, as well as to the differentiated role that government regulation may play in this process. Based on this, this study takes institutional …
Integrated Computational And Experimental Investigation Of Groups V And Vi Metals In (M,Hf,Ti,Zr)B2-(M,Hf,Ti,Zr)C Ceramics, Ana C. Feltrin, Simon Divilov, Gregory E. Hilmas, Stefano Curtarolo, William G. Fahrenholtz
Integrated Computational And Experimental Investigation Of Groups V And Vi Metals In (M,Hf,Ti,Zr)B2-(M,Hf,Ti,Zr)C Ceramics, Ana C. Feltrin, Simon Divilov, Gregory E. Hilmas, Stefano Curtarolo, William G. Fahrenholtz
Materials Science and Engineering Faculty Research & Creative Works
Dual-phase compositionally complex ultra-high temperature ceramics were formulated by incorporating different Groups V and VI metals such as V, Nb, Ta, Cr, Mo, or W into a base composition containing the Group IV elements, Hf, Ti, and Zr. Metal distribution was predicted using first-principles-based thermodynamics simulations and compared with experimental results. Moreover, phase stability, microstructure, and mechanical properties were evaluated for all of the ceramics. Compositions containing Cr, V, Nb, or Ta formed dual-phase ceramics containing only one boride and one carbide phase, while compositions containing Mo or W developed an additional third phase. The experimental metal distribution trends generally …
Co-Calcination Of Limestone And Clay Enhances The Performance Of Limestone Calcined Clay Cement (Lc3), Oluwadamilare Charles Adesina, Sahil Surehali, Avinaya Tripathi, Kayla Lauren Lee, Bryan K. Aylas-Paredes, Aditya Kumar, Narayanan Neithalath
Co-Calcination Of Limestone And Clay Enhances The Performance Of Limestone Calcined Clay Cement (Lc3), Oluwadamilare Charles Adesina, Sahil Surehali, Avinaya Tripathi, Kayla Lauren Lee, Bryan K. Aylas-Paredes, Aditya Kumar, Narayanan Neithalath
Materials Science and Engineering Faculty Research & Creative Works
Limestone-calcined clay cements (LC3) reduce the environmental impact of cement production and accelerate the industry transition toward carbon neutrality. While conventional LC3 with 50% clinker replacement (LC3-50) demonstrate long-term performance comparable to ordinary Portland cement (OPC) in concrete, early-age performance is generally compromised. This study explores for the first time, joint thermal treatment—that is, co-calcination—of limestone (LS) and bulk kaolinitic clay in mass ratios of 1:1 to 1:4 under a calcination regime specifically designed to ensure activation of the clay mineral. The co-calcination converts a small fraction of LS to metastable CaO, thus providing an …
Inclusion Engineering Through Deoxidation Practice Optimization For Enhanced Mechanical Properties Of Cast Cr-Ni-Mo Steel, Kingsley T. Amatanweze, Viraj A. Athavale, Simon Lekakh, Ronald J. O'Malley, Laura N. Bartlett
Inclusion Engineering Through Deoxidation Practice Optimization For Enhanced Mechanical Properties Of Cast Cr-Ni-Mo Steel, Kingsley T. Amatanweze, Viraj A. Athavale, Simon Lekakh, Ronald J. O'Malley, Laura N. Bartlett
Materials Science and Engineering Faculty Research & Creative Works
Deoxidation is an integral part of steelmaking, as it determines steel castability, cleanliness, and porosity levels of the final product. Steel quality is critical to its performance and can be sabotaged by impurities such as non-metallic inclusions and porosity. This study investigates the effects of four distinct deoxidation practices, using Al, Al-Ca, Zr-Ca, and Mn-Si respectively, on tensile strength, tensile ductility and impact toughness of a Cr-Ni-Mo steel. These deoxidation reactions were modeled on a commercially available thermodynamic software and possible inclusion product phases were predicted. The casting samples were studied on a scanning electron microscope (SEM) utilizing energy dispersive …
Post-Calcium Treatment Evolution Of Alumina (Al2o3) Inclusions Morphology, Naziru I. Fuseini, Ronald J. O'Malley, Todd P. Sander, Jeffrey D. Smith, Haiming Wen, Laura N. Bartlett
Post-Calcium Treatment Evolution Of Alumina (Al2o3) Inclusions Morphology, Naziru I. Fuseini, Ronald J. O'Malley, Todd P. Sander, Jeffrey D. Smith, Haiming Wen, Laura N. Bartlett
Materials Science and Engineering Faculty Research & Creative Works
The post-calcium morphological evolution of Al2O3 inclusions formed under high-oxygen supersaturation (~1000 ppm) was investigated through time-resolved sampling and quenching of aluminum-killed, calcium-treated steel. SEM-EDS analysis revealed the formation of angular two-phase CaO·Al2O3–CaS inclusions within 1 minute, gradually transforming into spherical liquid 12CaO·7Al2O3 and CaO·Al2O3 with a thin CaS layer around it. The 3D morphology of the CaS phase of the complex CaO·Al2O3–CaS inclusions observed at 1 minute appeared as a cone-cap attached to the partially modified CaO·Al2O3. This …
Thermodynamic Analysis Of Metal Segregation In Two Metal Boride-Carbide Ceramics Containing V With Cr, Hf, Ti, Or Zr, Ana C. Feltrin, Simon Divilov, Gregory E. Hilmas, Stefano Curtarolo, William G. Fahrenholtz
Thermodynamic Analysis Of Metal Segregation In Two Metal Boride-Carbide Ceramics Containing V With Cr, Hf, Ti, Or Zr, Ana C. Feltrin, Simon Divilov, Gregory E. Hilmas, Stefano Curtarolo, William G. Fahrenholtz
Materials Science and Engineering Faculty Research & Creative Works
Dual-phase carbide-boride ceramics in different vanadium-Me (Me = Cr, Hf, Ti, and Zr) binary systems were synthesized by boro/carbothermal reduction under stoichiometric and carbon-deficient conditions and densified by spark plasma sintering. Thermodynamic analysis was used to evaluate the influence of composition on the phase stability and metal segregation between phases, along with the resulting effects on microstructure and hardness. Pairing vanadium with Group IV elements (Hf, Ti, and Zr) consistently formed one boride and one carbide phase, while the Cr-V system formed a monoboride phase and a carbon-deficient carbide. Metal segregation trends depended on composition. Vanadium preferentially segregated to the …
Zirconium And Hafnium Interdiffusion Study In Zrb2–Hfb2 System, Yue Zhou, Ana C. Feltrin, William G. Fahrenholtz, Gregory E. Hilmas
Zirconium And Hafnium Interdiffusion Study In Zrb2–Hfb2 System, Yue Zhou, Ana C. Feltrin, William G. Fahrenholtz, Gregory E. Hilmas
Materials Science and Engineering Faculty Research & Creative Works
Interdiffusion of Zr and Hf in the diboride system was investigated. High-purity zirconium diboride (ZrB2) and hafnium diboride (HfB2) were prepared by a combination of boro-/carbothermal reduction synthesis and densification by spark plasma sintering. The bulk ceramics had relative densities of 99.3% for ZrB2 and 99.7% for HfB2, and both ceramics were phase-pure by x-ray diffraction analysis. Diffusion couples of ZrB2 and HfB2 were annealed at temperatures ranging from 2000°C to 2200°C for times from 4 to 12 h. Zr and Hf elemental concentration profiles were measured using energy dispersive spectroscopy …
Examining The Effect Of Newcomers’ Adaptability On Proximal And Distal Outcomes Of Organizational Socialization, Vahe Permzadian, Mishra Vipanchi
Examining The Effect Of Newcomers’ Adaptability On Proximal And Distal Outcomes Of Organizational Socialization, Vahe Permzadian, Mishra Vipanchi
Psychological Science Faculty Research & Creative Works
We investigate the role of individual adaptability (I-ADAPT) in newcomer socialization by exploring its effects on the proximal and distal outcomes of the work-role transition process. Based on I-ADAPT theory, our study assesses how I-ADAPT affects the three key indicators of newcomer adjustment (i.e., role clarity, task mastery, and social acceptance) and, in turn, their effect on the distal socialization outcomes of job satisfaction, turnover intention, and work withdrawal. Using a 2-wave prospective design, we collected data from 280 newcomers recruited through Prolific. Results indicated that I-ADAPT dimensions differentially predict newcomer adjustment, with learning adaptability affecting role clarity, uncertainty adaptability …
Pardon And Power For The Christian Life: The Role Of Grace In Youth Formation, Sofia C. Van Hattem
Pardon And Power For The Christian Life: The Role Of Grace In Youth Formation, Sofia C. Van Hattem
Master of Art Theology Thesis
Van Hattem, Sofia C. “Pardon and Power for the Christian Life: The Role of Grace in Youth Formation.” M.A. Thesis, Concordia Seminary, 2026. 70 pp. Raising young people in the Christian faith is one of the principal tasks of the Church. Yet, congregations continue to face the persistent reality of youth slowly disengaging and leaving their home churches. This ongoing problem is foundational and affects congregations throughout The Lutheran Church—Missouri Synod (LCMS). This thesis addresses the importance of Christian youth formation by focusing on the core theological concept that shapes the Lutheran theology: grace. Founded on the Scriptures and the …
A General Limit Theory For Nonlinear Functionals Of Nonstationary Time Series, Qiying Wang, Peter C. B. Phillips
A General Limit Theory For Nonlinear Functionals Of Nonstationary Time Series, Qiying Wang, Peter C. B. Phillips
Research Collection School Of Economics
New limit theory is provided for a wide class of sample variance and covariance functionals involving both nonstationary and stationary time series. Sample functionals of this type commonly appear in regression applications and the asymptotics are particularly relevant to estimation and inference in nonlinear nonstationary regressions that involve unit root, local unit root, or fractional processes. The limit theory is unusually general in that it covers both parametric and nonparametric regressions. Self-normalized versions of these statistics are considered that are useful in inference. Numerical evidence reveals interesting strong bimodality in the finite sample distributions of conventional self-normalized statistics similar to …
Are Cities Losing Innovation Advantages? Online Versus Face-To-Face Interactions, Ruben Gaetani, Naqun Huang, Jing Li, Yanmin Yang
Are Cities Losing Innovation Advantages? Online Versus Face-To-Face Interactions, Ruben Gaetani, Naqun Huang, Jing Li, Yanmin Yang
Research Collection School Of Economics
How did COVID-19 affect the innovation advantages of dense locations? Using data on the universe of U.S. patent applications, we find that the density premium in the production of novel inventions declined by 18.5%-22.9% in 2020-2021 relative to its pre-pandemic level. Smartphone data on local mobility suggest that the drop in the frequency of local interactions can explain a significant portion of this effect. While COVID-19 resulted in a temporary setback in the innovation advantages of dense locations, the role of urban density in facilitating the exchange and recombination of ideas is unlikely to be persistently replaced by online communication.
Removed: When Taxi Drivers Meet Dynamic Pricing: A Lesson From Singapore's Justgrab Program, Shih-Fen Cheng, Wen-Tai Hsu, Jing Li
Removed: When Taxi Drivers Meet Dynamic Pricing: A Lesson From Singapore's Justgrab Program, Shih-Fen Cheng, Wen-Tai Hsu, Jing Li
Research Collection School Of Economics
This paper studies how dynamic pricing influences taxi drivers’ behaviors using a unique event, the inception of the JustGrab program in Singapore in 2017, which introduces dynamic pricing to some, but not all, taxi drivers. This is the first time in history that traditional taxi drivers have access to dynamic pricing. Using data covering the universe of taxi trips before and after the inception of JustGrab, we find that there is spatial reallocation that directs more taxi drivers to the previously less-served areas, that there is also a temporal reallocation that directs more taxi drivers to rush hours, as well …
Final 2022 Unreclaimed Sites Sampling: Ur-20 Site Evaluation Summary Report, Pioneer Technical Services, Inc.
Final 2022 Unreclaimed Sites Sampling: Ur-20 Site Evaluation Summary Report, Pioneer Technical Services, Inc.
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
G-Trac: Graph-Textual Representations Alignment For Cold-Start Recommendations, Li Yang Chang, Yuan Fang, Ming Feng Tsai, Chuan Ju Wang
G-Trac: Graph-Textual Representations Alignment For Cold-Start Recommendations, Li Yang Chang, Yuan Fang, Ming Feng Tsai, Chuan Ju Wang
Research Collection School Of Computing and Information Systems
The cold-start problem remains a significant challenge in recommendation systems, particularly for new users or unseen items with little to no historical data. Existing methods, including graph neural networks, often struggle in such scenarios. Inspired by the success of transformer models in natural language processing, we propose G-TRAC (Graph-Textual Representations Alignment for Cold-start Recommendations), a novel approach that integrates transformer-based textual modeling with graph neural networks. By effectively leveraging both textual and structural information, G-TRAC addresses cold-start challenges more effectively. Extensive experiments demonstrate its ability to enhance recommendation quality and generalize well across diverse scenarios.
Brand Switching Or Behavior Change: The 2023 Bud Light Boycott's Impact On Alcohol Purchases, Aljoscha Janssen
Brand Switching Or Behavior Change: The 2023 Bud Light Boycott's Impact On Alcohol Purchases, Aljoscha Janssen
Research Collection School Of Economics
I study how the 2023 Bud Light boycott affected overall alcohol demand using household-level panel data and a set of difference-in-differences designs. Focusing on households that, before April 2023, regularly purchased Bud Light, I find a large drop in Bud Light volume (34%–37%), partial switching into other beer (+70 to +90 ounces per month), and a net decline in total ethanol purchases of about 3–4 fl-oz per month, or roughly 5.5%–7.5% of pre-boycott intake. I detect no compensatory increase in wine or spirits. Scaled nationally, the quantity response is equivalent to roughly 150 million standard drinks per year; using CDC …
The Uncomfortable Truths About Inclusive Growth In Singapore, Kong Weng Ho
The Uncomfortable Truths About Inclusive Growth In Singapore, Kong Weng Ho
Research Collection School Of Economics
In a commentary, SMU Associate Professor of Economics (Education) Ho Kong Weng said that the Ministry of Finance’s Occasional Paper provides food for thought on the way forward on social mobility, growth and redistribution. Assoc Prof Ho stated that these macro statistics suggest Singapore’s socioeconomic compact has performed well, and suggests that sustaining inclusive growth is a multifaceted effort that cannot be boiled down to one single metric, whether income, wealth, inequality or mobility. He noted that pursuing ever-lower Gini coefficients through heavy regulation risks deadweight losses without guaranteeing better mobility outcomes. He added that Singapore’s approach of tempering market-driven …
The Global Extent Of The Grassland Biome And Implications For The Terrestrial Carbon Sink, A. S. Macdougall, B. Vanzant, J. Sulik, S. Bagchi, D. Naidu, T. O. Muraina, E. W. Seabloom, E. T. Borer, P. Wilfahrt
The Global Extent Of The Grassland Biome And Implications For The Terrestrial Carbon Sink, A. S. Macdougall, B. Vanzant, J. Sulik, S. Bagchi, D. Naidu, T. O. Muraina, E. W. Seabloom, E. T. Borer, P. Wilfahrt
Faculty Publications
Land cover data are commonly used to model the terrestrial carbon (C) sink, yet these data have wide margins of error that significantly alter estimates of global C storage. Here we demonstrate this data vulnerability in grasslands, which are critical to C cycling but whose estimated distribution has varied by >50 million km2 (3.5–42% of the Earth’s terrestrial surface). Comparing multiple high-resolution land cover products with expertly annotated grassland data from six continents, we show sources of mapping error and discuss C implications based on 2023 United Nations (UN) FAO estimates. Past misidentification arose from inconsistent definitions on grassland …
Sit, Stay, And Teach: Exploring Teachers' Perceptions Of Facility Dogs' Impact On Stress And Retention, Dennis Powers
Sit, Stay, And Teach: Exploring Teachers' Perceptions Of Facility Dogs' Impact On Stress And Retention, Dennis Powers
Graduate Student Dissertations, Theses, Capstones, and Portfolios
The teaching profession remains at a high level of workplace stress, a factor contributing to teacher burnout and turnover. The study examines how teachers in K-12 public education perceived that facility dogs might reduce stress, increase job satisfaction, and aid in teacher retention in public schools of a southeastern state. The study employed a qualitative, cross-sectional survey that was emailed to 112,546 educators from a LISTSERV request. A total of 1,242 individuals provided informed consent and completed the survey, which consisted of Likert-scale measurement items, open-ended questions, and an informational video inserted to achieve a common understanding of the facility …
Melody: Mediation Analysis In Logistic Regression For High-Dimensional Mediators And A Binary Outcome, Sunyi Chi, Xingyu Li, Peng Wei, Xuelin Huang
Melody: Mediation Analysis In Logistic Regression For High-Dimensional Mediators And A Binary Outcome, Sunyi Chi, Xingyu Li, Peng Wei, Xuelin Huang
Faculty, Staff and Student Publications
Mediation analysis is a pivotal tool for elucidating the indirect effect of an environmental factor or treatment on disease through potentially high‐dimensional omics data, such as gene expression profiles. However, traditional mediation analysis methods tailored for binary outcomes often rely on the rare disease assumption in logistic regression and provide inadequate measures of total mediation effect when multiple mediators have effects in different directions. In this paper, we develop a MEdiation analysis framework in LOgistic regression for high‐Dimensional mediators and a binarY outcome (MELODY). It leverages a second‐moment‐based measure analogous to the ��2 for linear models to quantify the total …
Longitudinal Peripheral Blood Transcriptomics Reveal Novel Signatures During Cardiac Allograft Rejection., Rachad Ghazal, Min Wang, Akshatha N. Srinivas, Jenny J. Cao, Hridyanshu Vyas, Duan Liu, Asha Nair, Byron H. Smith, Li Wang, Daniel S. Yip, Parag C. Patel, David E. Steidley, Brian W. Hardaway, Alfredo L. Clavell, Sudhir S. Kushwaha, Walter D. Park, Mark D. Stegall, Howard Eisen, Naveen L. Pereira
Longitudinal Peripheral Blood Transcriptomics Reveal Novel Signatures During Cardiac Allograft Rejection., Rachad Ghazal, Min Wang, Akshatha N. Srinivas, Jenny J. Cao, Hridyanshu Vyas, Duan Liu, Asha Nair, Byron H. Smith, Li Wang, Daniel S. Yip, Parag C. Patel, David E. Steidley, Brian W. Hardaway, Alfredo L. Clavell, Sudhir S. Kushwaha, Walter D. Park, Mark D. Stegall, Howard Eisen, Naveen L. Pereira
Division of Cardiology Faculty Papers
Background: Acute cellularrejection (ACR) remains a major cause of morbidity afterhearttransplantation despite advances in immunosuppression. Whole genometranscriptomicprofiling offers a systems-based, unbiased approach to elucidate the molecular mechanisms underlying ACR. However, noninvasive,longitudinal biomarker assessments capable of capturing the temporal dynamics ofrejection biology remain scarce.
Methods: RNA sequencing ofperipheralblood fromheart transplant recipients before, during, and after ACR was compared with nonrejection controls. Pathway analysis was conducted using differentially expressed genes (DEGs), and a machine learning approach was applied to assessgene-based prediction of ACR.
Results: A total of 235 rejection-specific significant DEGs and 863 postrejection DEGs (false discovery rate < 0.05) were identified. During ACR, DEGs were enriched for T-cell activation/differentiation, apoptosis, and B-cell receptor signaling pathways. By combining the 2 sets of DEGs, a panel of 71 common genes was identified that reflected the significant, longitudinal transcriptomic dynamics of ACR. In an elastic net machine learning-based classifier, DYNLL1 and SERF2 were …
Early Neonatal Admissions With Feeding Difficulties To Acute Paediatric Services At A Tertiary Paediatric Hospital In England: Sequential Audits Pre-Covid-19 And During The Covid-19 Pandemic, Kalvin Lee, Thomas Frederick Dunne, Mary Masoud, Hayley Gleig, Heidi Stott, Helen Nabwera, Halina Kamarova
Early Neonatal Admissions With Feeding Difficulties To Acute Paediatric Services At A Tertiary Paediatric Hospital In England: Sequential Audits Pre-Covid-19 And During The Covid-19 Pandemic, Kalvin Lee, Thomas Frederick Dunne, Mary Masoud, Hayley Gleig, Heidi Stott, Helen Nabwera, Halina Kamarova
Centre of Excellence in Women and Child Health
Introduction: Our objective was to describe the population of infants < 7 days of age admitted to the acute general paediatric services at Alder Hey Children’s Hospital and ascertain the proportion with feeding difficulties amenable to community-based support.
Methods: Sequential retrospective audits of all infants < 7 days of age admitted to acute paediatrics at Alder Hey Children’s Hospital, Liverpool, England, from March to September 2019 (pre-COVID-19) and March to September 2020 (during COVID-19). All the infants were born and discharged from maternity units in Merseyside, Northwest England. Anonymised data were extracted from the electronic clinical records by three members of the clinical team.
Results: Pre-COVID-19, 38.6% (93) of the 241 admissions to acute general paediatric services had feeding difficulties. 31.2% (29) presented solely with feeding difficulties and 31.2% (29) were exclusively breastfed. However, during COVID-19, although there were fewer admissions (104), more than half (51%, 54) had feeding difficulties and for 54% (29), this was the only reason for admission. Over half (53.7%, 29) were exclusively breastfed.
Conclusion: Our audits showed that at least a third of infants < 7 days of age admitted with feeding difficulties did not have any other features of severe illness. These admissions unnecessarily expose infants to hospital-acquired infections while disrupting the opportunity for families to build close and loving relationships that enhance the establishment of breastfeeding. Co-designing infant feeding strategies with the mothers and stakeholders will be a crucial next step to enhance infant feeding support, particularly in impoverished communities in the region.
“Now That The Baby Is Out, I Can Be Vaccinated”: A Qualitative Study On Covid-19 Vaccine Hesitancy In Pregnant Women In Kilifi, Kenya, Angela Koech, Onesmus Wanje, Grace Mwashigadi, Geoffrey Katana, Richmond Mdindi, Peter Mwangome, Rachel Craik, Marianne Vidler, Mai-Lei Kinshella, Marleen Temmerman
“Now That The Baby Is Out, I Can Be Vaccinated”: A Qualitative Study On Covid-19 Vaccine Hesitancy In Pregnant Women In Kilifi, Kenya, Angela Koech, Onesmus Wanje, Grace Mwashigadi, Geoffrey Katana, Richmond Mdindi, Peter Mwangome, Rachel Craik, Marianne Vidler, Mai-Lei Kinshella, Marleen Temmerman
Centre of Excellence in Women and Child Health
COVID-19 vaccines are safe and effective in pregnancy, but vaccine hesitancy limits uptake and effectiveness. This study explored COVID-19 vaccine hesitancy in pregnancy in Kilifi, coastal Kenya, to elicit reasons for vaccine hesitancy and acceptance, and to compile misconceptions around vaccination in pregnancy. Twenty-three in-depth interviews were conducted with pregnant women, mothers who had given birth in the previous 2 years and health workers (community health promoters, nurses, and supervisors). Data were analyzed using thematic template analysis based on the Vaccine Hesitancy Determinants Matrix. Concern about vaccine safety for the unborn baby was a major driver of hesitancy. Many pregnant …