Digital Commons Network^™

Chronic Alcohol Consumption Disrupts The Gut Microbial And Metabolic Landscapes, Madison B. Blanton, Ethan G. Napier, Katelyn E. Keen, Ethan V. Stuart, Isaac R. Cinco, Hami Hemati, Ronald C. Bruntz, Landon Wilson, Stephen Barnes, Rupak Khadka, Kathleen A. Grant, Ilhem Messaoudi

Pharmaceutical Sciences Faculty Publications

Introduction: Alcohol use disorder (AUD) increases incidence of infections, organ damage, and cancers. Aberrant inflammation is likely a driver of these adverse outcomes. Indeed, chronic alcohol consumption (CAC) rewires macrophages/monocytes toward a hyper-inflammatory phenotype. Prior studies showed increased gut permeability and dysbiosis. Translocation of host- and microbial-derived metabolites could trigger the hyper-inflammatory responses generated by macrophages/monocytes. However, the exact changes in these metabolites remain poorly defined due to confounders that complicate clinical studies and the differences between human and rodent gut microbiomes.

Methods: Here, we utilized a non-human primate model of ethanol self-administration to characterize alcohol-induced alterations in gut microbes …

Optimized Nano-Bilosomes Loaded Ocular Insert As A Promising Approach For Boosting Voriconazole Ocular Bioavailability: In-Vitro, Microbiological, And In-Vivo Assessments, Eman Gomaa

Nanotechnology Research Centre

The eye possesses numerous physiological barriers that significantly limit the absorption of administered drugs, as only < 5 % get through. These barriers restrict drug bioavailability, often necessitating multiple dosing, which can lead to poor patient compliance. The study goal is to efficiently incorporate Voriconazole (VRC), a wide-spectrum antifungal candidate with a short half-life, into stable, biocompatible, non-irritating bile salt nanoparticles (Bilosomes, BLOs) to enhance its ocular delivery. Bilosomes were prepared by the ethanol injection method. Experimental (33) Box–Behnken Design (BBD) was employed; the amount of bile salt, cholesterol, and span-60 were chosen as independent variables, while entrapment efficiency (EE%), cumulative VRC release (Q8h), particle size (PS), zeta potential (ZP), and polydispersity index (PDI) were the dependent variables. The formula of optimization showed EE% (59.04 ± 1.88 %), cumulative release after 8 h (81.35 ± 0.69 %), PS (222.53 ± 2.04 nm), ZP (−72.53 ± 1.75 mV), and PDI (0.225 ± 0.03). It was chemically characterized using DSC and FTIR. Its spherical arrangement was confirmed using TEM. For ophthalmic application, the optimized formula was included in ocular inserts to extend ocular residence time while minimizing dosing frequency. The optimal VRC-loaded bilosomal ocular insert met the acceptable physicochemical criteria, was sterilized using UV radiation for conducting microbiological assay, in-vivo study, and pharmacokinetic analysis. For safety evaluation, an eye irritation study and histopathological examination were conducted. The results confirmed its effectiveness as evidenced by a significantly larger inhibition zone and 8.39-fold enhancement in VRC bioavailability compared to its suspension. These findings support the potential of bilosomes-loaded ocular insert as an effective ocular delivery of VRC.

Infantile Epileptic Spasms Syndrome: Clinical Profile And Outcomes At A Tertiary Hospital In Kenya, Peninah Mwangi, Katherine Oyieke, Sam Gwer, Pauline Samia

Paediatrics and Child Health, East Africa

Background: Infantile epileptic spasms syndrome (IESS) is characterised by onset of epileptic spasms between 3 and 12 months, with or without typical hypsarrhythmia, and developmental stagnation or regression. There are limited data on the clinical profile and treatment outcomes of IESS in sub-Saharan Africa.

Objective: To describe the clinical profile and treatment outcomes of infants diagnosed with and managed for IESS at Aga Khan University Hospital, Nairobi.

Methods: Records of children aged 3–24 months diagnosed with IESS between January 2012 and December 2021 were identified from the hospital information system using the terms “infantile spasm”, “epileptic spasms”, …

Beyond Fixed Thresholds: Per-Label Calibration For Fine-Grained Emotion Detection On The Goemotions Dataset, Sai Puneet Naga Venkata Subramanyam Patchipulusu

Selected Full-Text Master Theses 2021-

This study investigates the effectiveness of five community fine-tuned transformer models for fine-grained emotion detection on the GoEmotions dataset: SamLowe/roberta- base-go_emotions (RoBERTa-base), cirimus/modernbert-base-go-emotions (ModernBERT), mrm8488/deberta-v3-base-goemotions (DeBERTa-v3-base), bhadresh-savani/bert-base-go- emotion (BERT-base-cased),and tasinhoque/distilbert-go-emotions (DistilBERT) . While the original GoEmotions research by Demszky et al. (2020) established a BERT-base baseline with a macro-F1 of 0.46, this thesis extends that work through independent empirical evaluation of five derivative models, systematic per-label threshold optimization, and comparative analysis of architectural trade-offs across the full transformer model family. Using the GoEmotions simplified test split (5,427 examples across 28 categories), all five models were evaluated at a fixed 0.5 …

Solving The Middle School Math Problem To Increase Achievement, Andre Goodlow

Educational Leadership Professional Doctorate Dissertations

This study used improvement science to address persistent and disproportionate low mathematics achievement among middle school students, particularly Black/African American and Hispanic students, in an urban school district in the Pacific Northwest. Local data indicated significant deficiencies in math proficiency, with the target district exhibiting achievement disparities exceeding state averages. The project investigated root causes of low math achievement, prioritizing the enhancement of foundational math skills and the implementation of evidence-based interventions. The improvement theory centered on deploying an evidence-based core math curriculum and intervention program for incoming middle school students, tested through cycles during a four-week summer school program. …

Pláticas Of Latinas In Educational Leadership: Stories Of Identity, Resilience, And Transformation, Vanessa Davalos

Educational Leadership Professional Doctorate Dissertations

Despite federal and state equity laws that prohibit discrimination based on sex and national origin, women remain significantly underrepresented in K–12 educational leadership, with Latina leaders experiencing even greater disparities. While the number of Hispanic students in public schools continues to grow, the representation of Latina leaders has not kept pace, creating a critical gap between those leading schools and the communities they serve.

The purpose of this qualitative phenomenological study is to provide insight into the lived experiences of Latina educational leaders in order to deepen understanding of how identity, role, and leadership intersect (Hernandez & Murakami, 2016). Centering …

Establishing A Public Health Surveillance System For The Opioid Crisis: The Experience Of The Healing Communities Study, Bridget Freisthler, Daniel J. Feaster, Charles Knott, Marc Larochelle, John Mccarthy, Svetla Slavova, Sharon L. Walsh, Jennifer Villani

Biostatistics Faculty Publications

Introduction: Efforts to reduce opioid overdose deaths in the United States have been stymied by the lack of timely and standardized population-level data for local, state, and national levels. The U.S. has a strong national need for linking opioid and other drug overdose surveillance data to service utilization data for overdose prevention and treatment to inform resource allocation and response planning.

Methods: We provide insight on the challenges of identifying, obtaining, and harmonizing administrative outcome data across four states using the collective experience from the HEALing Communities Study to test a community-engaged, data-driven, population-level intervention to reduce opioid overdose deaths. …

Pediatric Clinical Reasoning Labs’ Impact On Student Self-Efficacy In Pediatric Physical Therapy Education, Bethany Early

Dissertations

All graduates of entry-level Doctor of Physical Therapy (DPT) programs must be competent to work with patients across the lifespan and high levels of perceived self-efficacy (SE) may be a predictor of future success. Experiential learning is an effective teaching and learning strategy used within Pediatric PT education (PedPTE). This study examined the extent to which pediatric clinical reasoning labs impact student SE within PedPTE, and to what extent does previous experience or interest in pediatrics have on perceived SE.

The methodology was a sequential explanatory mixed methods research design. Quantitative data collection included 27 second year DPT students, utilizing …

Correspondence, To President Johnson, From The Citizens To Preserve Overton Park, 1964

Documents

A copy letter to the United States President Johnson, Washington, D.C., from the Citizens to Preserve Overton Park and Chairman, Mrs. Ralph W. Handy (Marie Handy), Memphis, Tennessee, 1964 July 6. This is about the concern of the routing of Interstate Highway 40 through Overton Park in Memphis. Marie wrote, "no ans!" on the letter.

From Voice To Noise: Accented Speech, Constructed Languages, And Subtitling Practices As Markers Of Difference, Alice Alonso Limongi

Course Work

This monograph explores three main strategies of vocal exotification in Anglophone film: representations of accented speech, inclusion of constructed languages, and non-subtitling of snippets of other languages. Using Stuart Hall’s encoding/decoding framework, I approach these practices as rhetorical devices that both construct and are constructed by the complexity of our social landscapes. Portrayals of accented speech, constructed languages, and subtitling practices form a gradient of abstraction, where the denotative meaning of words gradually loses importance to the sonic characteristics of the voice. Combining broader cultural scholarship from Edward Said, sound studies writings on power and language from Nina Sun Eidsheim …

Program, University Of Tennessee Department Of Dentistry, 1904-1905

Documents

A programme of lectures from the University of Tennessee Department of Dentistry, 1904-1905.

Enabling Communication Resiliency In The Connected Car Environment, Antonio Guerrero-Ibáñez, Juan Contreras-Castillo, Sherali Zeadally, Een-Kee Hong

Information Science Faculty Publications

Connectivity has become integral to various application domains, with the automotive sector as a prime example. Advances in electronics, computing, and telecommunications have driven the evolution of the connected car ecosystem, transforming it into a data-rich environment that enhances road safety, efficiency, and overall mobility. However, the success of this ecosystem depends on seamless, reliable, and resilient communications. We identify key challenges that may affect communications in the connected car environment and discuss solutions that enhance resiliency and robustness. Finally, we propose a multi-layered network architecture that will enhance communication resilience in the connected car ecosystem.

Curriculum In Pharmacoepidemiology Training Programs: A Cross-Sectional Study To Assess Educational Needs And Alignment With Core Competencies, Amie Goodin, Deborah Layton, Ryan Chung, Vicki Osborne, Chioma Ejekam, Xiaojuan Li, Xuerong Wen, Kristian B. Filion, Luciane Cruz Lopes, Daniela C. Moga

Pharmacy Practice and Science Faculty Publications

Purpose: Pharmacoepidemiology is a key discipline for evidence-based decision-making, yet its educational programs have not been systematically assessed for alignment with international core competencies. Our objectives were to evaluate curricula alignment of pharmacoepidemiology training programs with ISPE-recommended core competency themes and identify key curriculum content development areas.

Methods: The ISPE Core Competencies Workgroup and ISPE leadership developed a curriculum and needs assessment survey, incorporating feedback from global members. The survey was electronically distributed to leaders of pharmacoepidemiology training programs (e.g., department chairs and program directors) using the ISPE contact database, followed by snowball sampling to enhance representation. Institutional respondent characteristics …

Family Functioning And Stress In Arab American Young Adults, Sahar Kaouk

Selected Full-Text Dissertations 2020-

Family functioning plays a central role in the lives of Arab American young adults, yet little research has examined how family dynamics relate to stress in this population. Guided by Bowen’s (1978) Family Systems Theory, this study investigated the relationship between family functioning and perceived stress, as well as the roles of Differentiation of Self (DoS), Reflective Coping, and collectivistic orientation. Participants included 225 young adults ages 18 to 25 who self-identified as Arab American. Data were collected using self-report measures, and structural equation modeling was used to test the hypothesized model. Results indicated that family functioning was indirectly related …

Pamphlet, The Great Book, Ellen Davies-Rodgers, 1973

Documents

A pamphlet advertising, "The Great Book, Calvary Protestant Episcopal Church, 1832-1972, Memphis, Tennessee" by Ellen Davies-Rodgers, published by The Plantation Press, Davies Plantation Road, Brunswick, Tennessee, 1973.

Catalogue, Marion Female Seminary, Marion, Alabama, 1901-1902

Documents

A catalogue of the sixty-sixth annual session of Marion Female Seminary, Marion, Alabama, 1901-1902.

Correspondence, From Memphis Mayor Ingram, To Mrs. Ralph W. Handy, 1964

Documents

A letter from Memphis Mayor William B. Ingram to Mrs. Ralph W. Handy (Marie Handy), Memphis, Tennessee, 1964 October 21. This is "relative to efforts that you have made to preserve Overton Park."

0897: William A. “Red” Dawson Collection, 1915-2023, Marshall University Special Collections

Guides to Manuscript Collections

William Alfred “Red” Dawson, a native of Valdosta, Georgia, led his high school football team to a state championship and played for four years at Florida State University. Dawson briefly played professional football for the Boston Patriots in the AFL and the Orlando Panthers. He was serving as an assistant football coach at Marshall University when a fatal plane crash killed seventy-five players, coaches, staff, and prominent citizens of Huntington. Dawson was essential in restarting the Marshall University football program, serving as acting head coach and coached through the 1971 season. He then began working in the construction industry and …

Delivering Safe Sleep And Breastfeeding Education To Pregnant And New Mothers Through Private Facebook Groups: Study Protocol For A 4-Armed Randomized Controlled Trial, Rebecca F. Carlin, Margaret G. Parker, Ann L. Kellams, Fern R. Hauck, Stephen Kerr, Benjamin T. Cornwell, Marc T. Kiviniemi, Nicole Geller, Katherine E. Boguszewski, Michael J. Corwin, Eve R. Colson, Rachel Y. Moon

Health, Behavior & Society Faculty Publications

Background: Annually, more than 3500 US infants die suddenly and unexpectedly. Many sudden unexpected infant deaths (SUID) are preventable with greater adherence to safe infant sleep guidelines. There are racial and economic disparities in guideline adherence and SUID rates. Education alone has proven ineffective at altering behavior for many parents, and social networks and social norms regarding infant care have been found to influence rates of unsafe sleep. Using the power of social networks to shape social norms by delivering education through moderated online social media groups provides a unique opportunity to influence these practices in large groups of parents. …

Program, Mid-South Fair Rodeo, 1961

Documents

A program for the World's Championship Rodeo at the Mid-South Fair, Memphis, Tennessee, 1961 September 22-30. There were performances daily at 2:00 p.m. and 7:45 p.m., except Wednesday and Thursday. It was produced by Jim Shoulders and Announced by Senator Clem McSpadden, Oklahoma.

Flyer, Save Overton Park, Memphis, 1964

Documents

A flyer for the Save Overton Park movement, made by the Citizens to Preserve Overton Park, Memphis, Tennessee, 1964. "Look what the X-way did to Riverside - don't let it happen to Overton Park."

Poem, "Save Overton Park," 1964

Documents

A poem, "Save Overton Park," by Warren S. Webb, 1964 June 21.

Yearbook, Overton Park Garden Club, 1963-1968

Documents

A yearbook for the Overton Park Garden Club, Memphis, Tennessee, 1963-1968. This is Marie Handy's copy, and she wrote inside, "We don't want road hwy in any form in Overton Park."

Document, Resolution Adopted By Memphis Council Of Civic Clubs

Documents

A document listing a "Resolution Adopted by Memphis Council of Civil Clubs," Memphis, Tennessee, undated. This is about the concern of the routing of Interstate Highway 40 through Overton Park in Memphis.

"TO YOU WHO Believe in KEEPING Our City Parks - Overton Park - PRESERVING Natural Areas of Land and SAVING Memphis' Heritage"

Correspondence, To Senator Albert Gore, From The Citizens To Preserve Overton Park, 1964

Documents

A draft letter to Tennessee Senator Albert Gore, Washington, D.C., from the Citizens to Preserve Overton Park, and Chairman, Mrs. Ralph W. Handy (Marie Handy), Memphis, Tennessee, 1964 June 19. Marie wrote notes on the letter, including one she wrote three times, that says, "same letter to Senator Walters." The letter was regarding "the proposed six-lane coast-to-coast U.S. Interstate 40 highway with its cloverleaf, going through or in any part of Overton Park."

University Education Model; Co-Development, Socialisation, Support, Influence And Implementation 2021-2026, Shaun Ferns, Barry J. Ryan, Fionnuala Darby

Report

This report provides a reflective institutional analysis of TU Dublin’s University Education Model (UEM), appraising its co-development, socialisation, support structures, influence, and the status of its implementation. It has been informed by the institutional conditions that shaped integration and considered with reference to the UEM external reporting requirements associated with the Technological Sector Advancement Funding (TSAF).

Structured Interactions With Llms To Support Ltl: Supplemental Information, Karenna Kung, Maanas Punuru, Alicia M. Grubb, Paola Spoletini

Computer Science: Faculty Publications

This repository contains the supplemental information for the paper: "Structured Interactions with LLMs to Support LTL", which investigates how students interact with and can be supported by LLM explanations while translating linear temporal logic formulae into English natural language.

Democracy And Development In American History, Michael T. Rock

Economics Faculty Research and Scholarship

No abstract provided.

Hyena Den Distribution, Human-Hyena Interactions And Mitigation Strategies In The Greater Amboseli Ecosystem, Katherine Elizabeth Davis Matczak

Honors Theses and Capstones

The Spotted Hyena (Crocuta crocuta) is a prevalent predator across Africa, recognized for their noticeable gait and powerful jaws which enable them to maul and scavenge on prey. Due to human population growth and encroachment onto wildlife territory, the overlap between human settlements and hyena den sites has become a growing concern, particularly regarding livestock predation. Livestock is intrinsic to livelihoods across Africa, with most individuals deriving their livelihoods from pastoralism. This paper provides an evaluation of den proximities to communities, hyena diet preference, human-hyena conflict/attitudes, and mitigation strategies used to protect hyenas, livestock, and the people. Results …

New Hampshire Tcap, Riley Lane

Honors Theses and Capstones

No abstract provided.