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Super Bowl Lx: How Have Analytics Helped The Patriots? A Unh Expert Weighs In, Aaron Sanborn Feb 2026

Super Bowl Lx: How Have Analytics Helped The Patriots? A Unh Expert Weighs In, Aaron Sanborn

UNH Today Archive

No abstract provided.


Debt’S Dominion: A New Epilogue, David Skeel Feb 2026

Debt’S Dominion: A New Epilogue, David Skeel

BYU Law Review

This Essay, written for the “Who Governs Debt’s Dominion” symposium, looks back on Debt’s Dominion: A History of Bankruptcy Law in America as the twenty-fifth anniversary of the book’s publication nears. The Essay begins, in Part I, by briefly describing how Debt’s Dominion came about. Part II identifies and seeks to explain a striking decline in optimism about American bankruptcy law since Debt’s Dominion was first published. Part III explores a few of the major recent developments in consumer bankruptcy, small business bankruptcy, and large-scale corporate reorganization that I would have analyzed in the book if it were written today. …


Green Rules, Fragmented Fields: Member-State Approaches To Sustainability In Eu Competition Law, Niccolò Galli, Armando Santoni Feb 2026

Green Rules, Fragmented Fields: Member-State Approaches To Sustainability In Eu Competition Law, Niccolò Galli, Armando Santoni

Yearbook of Antitrust and Regulatory Studies

This article provides a comparative, normative-evaluative examination of how sustainability is being incorporated into European competition law. Combining doctrinal legal analysis with economic reasoning, it clarifies competing definitions of sustainability, maps the contest between the consumer-welfare paradigm and sustainability proponents, and evaluates the legal and institutional implications of the Commission’s 2023 Horizontal Cooperation Guidelines. Drawing on national initiatives across Member States plus the UK, the study highlights contrasting instruments, from Austria’s statutory environmental exemption to the Dutch soft-law safe harbour and Greece’s experimental sustainability sandbox, and shows how these divergent approaches produce fragmentation and legal uncertainty for cross-border cooperative initiatives. …


The Rider (2026-02-02), Daniela Chapa-Reyes Feb 2026

The Rider (2026-02-02), Daniela Chapa-Reyes

The Rider Archives

Vol. 11, No. 17


Law School News: Roger Williams University Marks Fred Korematsu Day With Reflection On Rights And Responsibility 02-02-2026, Kelly Brinza, Roger Williams University School Of Law Feb 2026

Law School News: Roger Williams University Marks Fred Korematsu Day With Reflection On Rights And Responsibility 02-02-2026, Kelly Brinza, Roger Williams University School Of Law

Life of the Law School (1993- )

No abstract provided.


Which Law School Is Right For Me? Admissions Q&A With Dean Estrada, New York Law School Feb 2026

Which Law School Is Right For Me? Admissions Q&A With Dean Estrada, New York Law School

NYLS Community News

No abstract provided.


Biologically-Inspired Multiscale Neuromorphic Architecture, Christian O'Reilly, Ramtin Zand Feb 2026

Biologically-Inspired Multiscale Neuromorphic Architecture, Christian O'Reilly, Ramtin Zand

Publications

This white paper proposes a biologically-inspired multiscale neuromorphic architecture that bridges key gaps between artificial neural networks (ANNs), spiking neural networks (SNNs), and biological neural networks (BNNs). While SNNs offer promising energy efficiency, their broader adoption remains limited by suboptimal performance and the need for novel learning paradigms. To address these challenges, the proposed framework integrates structural and functional principles observed in the brain, including hierarchical organization, sparse and modular connectivity, predictive coding, and diverse neuronal dynamics.

The architecture operates across micro-, meso-, and macro-scales, incorporating neuron-level diversity (e.g., excitatory/inhibitory and principal/support cells), canonical microcircuits (CMCs), and large-scale hierarchical organization. …


Data For "Unified Vapor Pressure Correlations For Lanthanide And Actinide Chlorides: An In-Depth Statistical And Thermodynamic Approach", J. Marvin Torrie, Nicolas Marvin Christensen, Kyle Duke, Carlos Mejia, Larry Baxter, Devin Rappleye Feb 2026

Data For "Unified Vapor Pressure Correlations For Lanthanide And Actinide Chlorides: An In-Depth Statistical And Thermodynamic Approach", J. Marvin Torrie, Nicolas Marvin Christensen, Kyle Duke, Carlos Mejia, Larry Baxter, Devin Rappleye

ScholarsArchive Data

This submission contains machine readable data (.csv) for all data from the publication "Unified Vapor Pressure Correlations for Lanthanide and Actinide Chlorides: An In-depth Statistical and Thermodynamic Approach". It contains the data contained in all figures in the paper and its supplementary material except for the water vapor pressure data in Figures 1 and 2. In addition, this submission contains all the original vapor pressure measurements (241 sets) from the sources reviewed in the paper.  Sufficient information is provided that readers can identify the original sources of these data sets if needed.


Qualitatively Assessing Trade-Offs And Co-Benefits At Local Scales When Considering Carbon Outcomes Among Other Management Goals, Adrienne B. Keller, Ann L. Calhoun, Stephen D. Handler, Maria K. Janowiak, Caitlin E. Littlefield, Brian Miner Feb 2026

Qualitatively Assessing Trade-Offs And Co-Benefits At Local Scales When Considering Carbon Outcomes Among Other Management Goals, Adrienne B. Keller, Ann L. Calhoun, Stephen D. Handler, Maria K. Janowiak, Caitlin E. Littlefield, Brian Miner

Michigan Tech Publications

Natural and working lands are often touted as natural climate solutions due to their ability to take up and store carbon, and land managers are increasingly tasked with considering how management actions impact carbon outcomes alongside other management goals. As a result, there is a need to assess how management actions may drive trade-offs and co-benefits between multiple management goals. However, quantitative analysis of trade-offs is not feasible for many local-scale management projects. We used a case study in an oak savanna in south-eastern Wisconsin, U.S.A. to develop and test a framework for qualitatively analysing local-scale trade-offs. Our framework is …


4-Chlorobenzylamine Containing Maleic Acid Derivatives: Synthesis, In Silico Studies, And Anti-Alzheimer’S Activity, Muhammad Junaid Tariq, Madiha Kanwal, Athar Ata, Humaira Nadeem, Mahwish Siddiqui Feb 2026

4-Chlorobenzylamine Containing Maleic Acid Derivatives: Synthesis, In Silico Studies, And Anti-Alzheimer’S Activity, Muhammad Junaid Tariq, Madiha Kanwal, Athar Ata, Humaira Nadeem, Mahwish Siddiqui

Michigan Tech Publications

One way to protect neurons is to protect them from oxidative damage by reducing lipid peroxidation (LPO). Therapeutic medicines that target the inflammatory response have antioxidant activities and can also block inflammatory cascade pathways and counteract cell lyses. The goal of this investigation was to see if new maleic acid derivatives could protect the brain from scopolamine-induced amnesia. To evaluate and characterize the maleic acid derivatives, spectroscopic techniques such as 1H NMR and Fourier Transform Infrared Spectroscopy (FTIR) were used. To further evaluate the synthesized compounds, an in vitro DPPH antioxidant assay was performed, compound 2f exhibited the best …


Anxiety Or Depression Trends By Disability Status And Demographic Intersections In Us Adults, 2019-2023, Faustine Williams Feb 2026

Anxiety Or Depression Trends By Disability Status And Demographic Intersections In Us Adults, 2019-2023, Faustine Williams

Faculty, Staff and Student Publications

Importance: Mental health problems, particularly anxiety and depression, remain among the leading causes of disease burden in the US. However, trends in anxiety and depression across disability status and demographics remain understudied.

Objective: To examine trends in anxiety and depression prevalence among US adults from 2019 to 2023 by disability status and demographic characteristics.

Design, setting, and participants: This cross-sectional study used national population-based data from the National Health Interview Surveys from 2019 to 2023. Data were collected from household probability samples of noninstitutionalized US civilian adults aged at least 18 years. Data analyses were performed from December 6, 2024, …


National Landscape Of Pediatric And Adult Inpatient Sickle Cell Disease Care, Ashley M. Jenkins, Spoorthy Vangala, Matthew Mcintosh, Robert Legros, Sophie Lanzkron, Kevin Fiscella Feb 2026

National Landscape Of Pediatric And Adult Inpatient Sickle Cell Disease Care, Ashley M. Jenkins, Spoorthy Vangala, Matthew Mcintosh, Robert Legros, Sophie Lanzkron, Kevin Fiscella

Department of Medicine Faculty Papers

No abstract provided.


Mom Is Developing Too: Preliminary Evidence For The Reciprocal Effects Of Infant Sensory Reactivity And Maternal Behavior, Emily C. Sweiss, Vincent Berardi, Elysia Poggi Davis, Curt A. Sandman, Laura M. Glynn Feb 2026

Mom Is Developing Too: Preliminary Evidence For The Reciprocal Effects Of Infant Sensory Reactivity And Maternal Behavior, Emily C. Sweiss, Vincent Berardi, Elysia Poggi Davis, Curt A. Sandman, Laura M. Glynn

Psychology Faculty Articles and Research

Caregiver sensitivity to infant cues is well-established as a predictor of child development. Infants also actively influence their social environment, especially their caregivers, even from their earliest days. Sensory reactivity, characterized as hypo- (under) and hyper- (over) responding to environmental stimuli, is one domain of development that is likely to influence caregiver-infant interaction, due to its role in regulating emotions and responses to both physical and social stimuli. Although sensory reactivity could be an important target for improving caregiver-child interaction, the longitudinal, reciprocal relations between infant sensory reactivity and caregiver behaviors are currently unknown. In the present proof-of-concept study, we …


Silenced Minds: How Philosophy’S Mind Over Body Divide Became A Gender Divide, Ryan Howard Feb 2026

Silenced Minds: How Philosophy’S Mind Over Body Divide Became A Gender Divide, Ryan Howard

Father Jack McGrath, S.M., Research Award Presentations

Ryan Howard is a recipient of the 2026 Father Jack McGrath, S.M., Award for Research in Catholic Intellectual Traditions.


Hopelessness: Nothing Left But Silence Forging Silent Peacemakers Who Endure, Noah Novotny Feb 2026

Hopelessness: Nothing Left But Silence Forging Silent Peacemakers Who Endure, Noah Novotny

Father Jack McGrath, S.M., Research Award Presentations

Noah Novotny is a recipient of the 2026 Father Jack McGrath, S.M., Award for Research in Catholic Intellectual Traditions.


Veteran Families In The 2025 Mfls: Community, Transition Needs, And Family Financial Situation, Jeanette Harvie, Rosalinda V. Maury Feb 2026

Veteran Families In The 2025 Mfls: Community, Transition Needs, And Family Financial Situation, Jeanette Harvie, Rosalinda V. Maury

Institute for Veterans and Military Families

The 2025 Military Family Lifestyle Survey (MFLS), a collaboration between Blue Star Families and Syracuse University's D'Aniello Institute for Veterans and Military Families since 2014, was released Feb 3, 2026. This year, the survey collected responses from over 6,000 military-connected individuals, including 2,846 veteran family respondents. Key findings include that 58% of veteran respondents described their military-to-civilian transition as difficult, with many reporting significant unmet needs for housing assistance, caregiving resources, and financial planning support at the time of transition. Preliminary analysis showed that veteran families who experienced difficult transitions may experience worse long-term outcomes, with 39% currently struggling financially …


Search For Low-Mass Electron-Recoil Dark Matter Using A Single-Charge Sensitive Supercdms-Hvev Detector, M. F. Albakry, I. Alkhatib, D. Alonso-González, J. Anczarski, T. Aralis, T. Aramaki, I. Ataeelangroudy, C. Bathurst, R. Bhattacharyya, A. J. Biffl, P. L. Brink, M. Buchanan, R. Bunker, B. Cabrera, R. Calkins, R. A. Cameron, C. Cartaro, D. G. Cerdeño, Y. Y. Chang, M. Chaudhuri, J. H. Chen, R. Chen, N. Chott, J. Cooley, H. Coombes, P. Cushman, R. Cyna, S. Das Feb 2026

Search For Low-Mass Electron-Recoil Dark Matter Using A Single-Charge Sensitive Supercdms-Hvev Detector, M. F. Albakry, I. Alkhatib, D. Alonso-González, J. Anczarski, T. Aralis, T. Aramaki, I. Ataeelangroudy, C. Bathurst, R. Bhattacharyya, A. J. Biffl, P. L. Brink, M. Buchanan, R. Bunker, B. Cabrera, R. Calkins, R. A. Cameron, C. Cartaro, D. G. Cerdeño, Y. Y. Chang, M. Chaudhuri, J. H. Chen, R. Chen, N. Chott, J. Cooley, H. Coombes, P. Cushman, R. Cyna, S. Das

All Works

We present constraints on low-mass dark matter electron scattering and absorption interactions using a SuperCDMS high-voltage eV-resolution (HVeV) detector. Data were taken underground in the NEXUS facility located at Fermilab with an overburden of 225 meters of water equivalent. The experiment benefits from the minimizing of luminescence from the printed circuit boards in the detector holder used in all previous HVeV studies. A blind analysis of 6.1 g·days of exposure produces exclusion limits for dark matter-electron scattering cross sections for masses as low as 1 MeV/c2, as well as on the photon-dark photon mixing parameter and the coupling …


Ndls Communicator: Week Of 02.02.26, Notre Dame Law School Feb 2026

Ndls Communicator: Week Of 02.02.26, Notre Dame Law School

NDLS Communicator

The Latest News

  • 2026 Galilee Immersion Program: Exposing First-Year Law Students to the Impact of Public Interest Law
  • Professor Jeffrey Pojanowski Named Inaugural Sydney Public Law Visiting Fellow

Student News

  • The Office of the United Nations High Commissioner for Human Rights (OHCHR)’s Knowledge Hub for Economic, Social and Cultural Rights has published a new issue brief co-produced with the Notre Dame Global Human Rights Clinic. Student researchers and drafters from the Clinic worked closely with Professor Diane Desierto and research associate Faisal Yamil Meneses in contributing to the brief.

Faculty Briefs

  • A.J. Bellia
  • Michael Addo
  • Fr. John Paul Kiimes
  • Nicole …


The George-Anne Daily, Georgia Southern University Feb 2026

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.


Exploring Enacted Active Learning Practices In Postsecondary Chemistry Lecture And Laboratory Courses, Kendall M. Zammit Feb 2026

Exploring Enacted Active Learning Practices In Postsecondary Chemistry Lecture And Laboratory Courses, Kendall M. Zammit

USF Tampa Graduate Theses and Dissertations

The work in this thesis begins to explore the enacted active learning practices in postsecondary chemistry lecture and laboratory courses. Chapter 1 explores the level of inquiry in postsecondary laboratories. Chapter 2 explores instructional and assessment practices at two-year institutions.

Chemistry postsecondary laboratories offer a unique opportunity to engage students in inquiry-based instruction. Inquiry-based instruction was categorized by the asking faculty members at four-institutions about six characteristics of laboratory design: choosing a problem, background research, designing procedures, analyzing data, communicating results, and interpreting results. As students have the freedom to make decisions on more characteristics of inquiry learning, the closer …


20260202: President's Papers, 1948-2004, President's Office Feb 2026

20260202: President's Papers, 1948-2004, President's Office

Guides to University Archives

These items include materials from the office of the President at Marshall University from 1948-2004. Items were received in the mid 2000s and include notable materials including materials with or about President Stewart H. Smith, Alan Gould, John G. Barker, and James Wade Gilley. Items could include personnel policies, administrative policies, the establishment of a proposed Marshall Research Center (1963), Annual Performance Reports. Please download the inventory for a complete list of the contents.


Boronate Esters For The Binding And Detection Of Low Molecular Weight Volatile Amines, Xiaoning Li, James Boyt, Steven Sloope, Luke T. Lackovic, Mark D. Smith, James J. Lavingne Feb 2026

Boronate Esters For The Binding And Detection Of Low Molecular Weight Volatile Amines, Xiaoning Li, James Boyt, Steven Sloope, Luke T. Lackovic, Mark D. Smith, James J. Lavingne

Faculty Publications

Conjugated thiophene-based diboronate esters, 1–4, were synthesized to investigate how substituents on catechol alter the Lewis acidity and accessibility to boron, and influence binding interactions with low molecular weight Lewis basic amines. Crystallographic analysis indicated that both boron centres bind analyte and that Lewis base coordination induces deplanarization of the conjugated system. Spectroscopic studies demonstrate that amine binding disrupts conjugation, producing distinct and reproducible optical responses that depend on analyte basicity and structure, with association constants in organic solvent ranging from 103 to 106 M−1. Quantitative binding analyses indicate strong negative cooperativity between the two boron …


A Robust Framework For Solving Pdes: Biorthogonal Spline Wavelet Methods, Mutaz Mohammad, Alexander Trounev Feb 2026

A Robust Framework For Solving Pdes: Biorthogonal Spline Wavelet Methods, Mutaz Mohammad, Alexander Trounev

All Works

This paper presents a novel numerical approach for solving the partial differential equations (PDEs), focusing on the Diffusion equation. The method combines a collocation approach with wavelet techniques to achieve high accuracy in approximating solutions. A detailed framework for the proposed method, explaining the discretization process at multiple collocation points and the formulation of the resulting system of linear equations is provided. An implementation is conducted to demonstrate the method's effectiveness in capturing the complex behaviors typical of the model studied. Comparisons with analytical solutions underscore the robustness and precision of the technique, paving the way for its application in …


Ice-Templated Zwitterionic Sponge Hydrogels For Stable And Efficient Solar Desalination In High-Salinity Brines, Louis D. Zhang, Yanhui Zhang, Peng Xiao, Chang Zhang Feb 2026

Ice-Templated Zwitterionic Sponge Hydrogels For Stable And Efficient Solar Desalination In High-Salinity Brines, Louis D. Zhang, Yanhui Zhang, Peng Xiao, Chang Zhang

University Research

Solar-driven steam generation (SSG) offers a sustainable pathway for desalination, yet achieving temperature-regulated control over macroporous structures in salt-tolerant hydrogels remains a critical challenge. Here, we report a carbon black-coated PDMAPS sponge hydrogel (PDMAPS-CB-SH) fabricated via an ice-templated polymerization strategy, where the pore size and connectivity are tuned by regulating ice-crystal growth at different prefreezing temperatures. The optimized PDMAPS-CB-SH integrates abundant interconnected pores with the intrinsic antipolyelectrolyte effect of zwitterionic networks, enabling rapid water transport and stable swelling in brines up to 10 wt % NaCl. Upon incorporation of carbon black nanoparticles, the hydrogel evaporator achieves a high evaporation rate …


Hangout Hour: A Safe Space Fostering Community Within The Adolescent Young Adult (Aya) Community, Brooke Ashmore, Makena Krier Feb 2026

Hangout Hour: A Safe Space Fostering Community Within The Adolescent Young Adult (Aya) Community, Brooke Ashmore, Makena Krier

2025



An Evaluation Of Structural Gaps And Systemic Barriers In The Entrepreneurship Ecosystem, Iryna V. Lendel, Chloe Wieber, Molly Schnoke Feb 2026

An Evaluation Of Structural Gaps And Systemic Barriers In The Entrepreneurship Ecosystem, Iryna V. Lendel, Chloe Wieber, Molly Schnoke

Upjohn Institute Technical Reports

This comprehensive study of Dayton, Ohio’s minority entrepreneurial ecosystem was supported by the Ewing Marion Kauffman Foundation. Based on a multi-year research effort and in-depth interviews with business support organizations (BSOs) and ecosystem stakeholders, the study examines how Dayton’s extensive network of entrepreneurial services supports minority and underrepresented entrepreneurs, identifies persistent gaps, and documents how the ecosystem has evolved amid COVID-19 disruptions, declining federal funding, and shifting approaches to diversity, equity, and inclusion. The study highlights strengths such as well-built early-stage support and collaborative service networks, alongside challenges including limited later-stage business assistance, fragmented entry points, misaligned performance metrics, and …


Detecting Stigmatizing Language In Clinical Notes With Large Language Models For Addiction Care, Rohan Sethi, John Caskey, Yanjun Gao, Matthew M. Churpek, Timothy A. Miller, Anoop Mayampurath, Elizabeth Salisbury-Afshar, Majid Afshar, Dmitriy Dligach Feb 2026

Detecting Stigmatizing Language In Clinical Notes With Large Language Models For Addiction Care, Rohan Sethi, John Caskey, Yanjun Gao, Matthew M. Churpek, Timothy A. Miller, Anoop Mayampurath, Elizabeth Salisbury-Afshar, Majid Afshar, Dmitriy Dligach

Computer Science: Faculty Publications and Other Works

Intensive care units (ICU) produce numerous progress notes that may contain stigmatizing language that perpetuate negative biases and punitive approaches against patients. Patients with substance use disorders are particularly vulnerable to stigma. This study examined the performance of Large Language Models (LLMs) in the identification of stigmatizing language. We annotated a dataset with over 77,000 stigmatizing and non-stigmatizing notes from the MIMIC-III database. We utilized Meta's Llama-3 8B Instruct LLM to run the following experiments for stigma detection: zero-shot; in-context learning; in-context learning with a selective retrieval; supervised fine-tuning (SFT); and keyword search. All approaches were evaluated on a held-out …


Estimated Effectiveness Of 2024-2025 Covid-19 Vaccination Against Severe Covid-19, Kevin C Ma, Jennie H Kwon, Et Al. Feb 2026

Estimated Effectiveness Of 2024-2025 Covid-19 Vaccination Against Severe Covid-19, Kevin C Ma, Jennie H Kwon, Et Al.

2020-Current year OA Pubs

IMPORTANCE: As SARS-CoV-2 JN.1 lineage descendants continue to evolve, evaluating COVID-19 vaccine effectiveness (VE) against severe COVID-19 remains important to guide vaccination strategies.

OBJECTIVE: To estimate the VE of the 2024-2025 COVID-19 vaccines against COVID-19-associated hospitalization and severe in-hospital outcomes overall and by time since dose (7-89, 90-179, and ≥180 days), JN.1 descendant lineage (KP.3.1.1, XEC, LP.8.1), and spike protein mutations associated with immune evasion.

DESIGN, SETTING, AND PARTICIPANTS: This multicenter, test-negative, case-control study conducted by the Investigating Respiratory Viruses in the Acutely Ill Network included adult patients (aged ≥18 years) hospitalized between September 1, 2024, and April 30, 2025, …


Costs Of Single Maintenance And Reliever Therapy Vs Traditional Therapy For Asthma, Tri Pham, Abigail R Barker, Sarah A Eisenstein, Eliot Jost, Anna Volerman, Krutika Chauhan, Ross C Brownson, Timothy Mcbride, Mark D Huffman, Kaharu Sumino, Lynn B Gerald, Mario Castro, Anne E Dixon, James G Krings Feb 2026

Costs Of Single Maintenance And Reliever Therapy Vs Traditional Therapy For Asthma, Tri Pham, Abigail R Barker, Sarah A Eisenstein, Eliot Jost, Anna Volerman, Krutika Chauhan, Ross C Brownson, Timothy Mcbride, Mark D Huffman, Kaharu Sumino, Lynn B Gerald, Mario Castro, Anne E Dixon, James G Krings

2020-Current year OA Pubs

IMPORTANCE: Despite strong guideline support, single maintenance and reliever therapy (SMART) for asthma is underused in the US. Limited insurance coverage of SMART-compatible inhalers remains a major barrier to its adoption.

OBJECTIVE: To compare the annual asthma management costs of SMART vs traditional therapy from a US health care payer perspective.

DESIGN, SETTING, AND PARTICIPANTS: This economic evaluation used a probabilistic decision-tree model with Monte Carlo simulations to compare the total asthma management costs for patients prescribed SMART vs traditional therapy, conducting analyses from September 1, 2024, to March 13, 2025. Input data were extracted through a systematic review of …


Amyloidosis Of Bridging Veins Is A Pathologic Feature Of Alzheimer's Disease, Leon C D Smyth, Daan Verhaege, Elio Standen-Bloom, Yue Wu, Steffen E Storck, Pavle Boskovic, Benjamin A Plog, Tornike Mamuladze, Jose A Mazzitelli, Zhuoying Wang, Daniel D Lee, Gwendalyn J Randolph, Katherine E Schwetye, Song Hu, Jonathan Kipnis, Et Al. Feb 2026

Amyloidosis Of Bridging Veins Is A Pathologic Feature Of Alzheimer's Disease, Leon C D Smyth, Daan Verhaege, Elio Standen-Bloom, Yue Wu, Steffen E Storck, Pavle Boskovic, Benjamin A Plog, Tornike Mamuladze, Jose A Mazzitelli, Zhuoying Wang, Daniel D Lee, Gwendalyn J Randolph, Katherine E Schwetye, Song Hu, Jonathan Kipnis, Et Al.

2020-Current year OA Pubs

Alzheimer's disease (AD) is characterized by the accumulation of extracellular aggregated amyloid beta, resulting from impaired waste clearance. We recently identified new cerebrospinal fluid (CSF) efflux structures termed arachnoid cuff exit (ACE) points and speculated that these may be impacted in AD, leading to impaired waste clearance function. Using 5XFAD mice, we found progressive amyloidosis of bridging veins at ACE points. Indeed, in 5XFAD mice, there is impaired CSF efflux to the dura mater, impaired CSF flow along bridging veins, and impaired blood flow through bridging veins. These observations suggest that ACE point amyloidosis plays a role in waste clearance …