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Highly Multiplexed Allogeneic Car T-Cell Engineering Using In Process Dna-Pk Inhibition, Marielle Summers, Jenna Fernandez, Yen Ho, Cédric Cleyrat, Ashley Thelen

Advancing Manufacture of Cell and Gene Therapies IX [2026]

Please click Additional Files below to see the full abstract

Mutations Altering The Dna Binding Domains Of The Human Rad52 Protein Exert Distinct Effects On Homologous Recombination Repair In Saccharomyces Cerevisiae, Glenn M. Manthey, Elise W. Wolf, Jason Xu, M. Cristina Negritto, Renee A. Bouley, Ruben C. Petreaca, Adam M. Bailis

College of Health Professions Faculty Papers

RAD52 is a conserved member of the homologous recombination repair (HRR) apparatus from yeast to humans. Mutating conserved amino acids in the internal and external DNA binding domains of the human RAD52 protein (HsRAD52) has discrete effects in vitro. Previous studies have shown that HsRAD52 supports multiple mechanisms of HRR in budding yeast, suggesting the utility of this model system for exploring the correspondence between losses of HsRAD52 function in vitro and their impact in vivo. We report that disrupting the internal and external DNA binding domains of HsRAD52 produced distinct effects on the repair of genomic DNA double-strand breaks …

The Hbcu Experience Panel : Why I Chose My Hbcu And How It Helped Me Prepare For My Career, Illinois Math And Science Academy, Angela Richardson

Educational Panels

Dr. Anita Connors White (Dean of Scholarship) - Panel Moderator

Angela Richardson (Information Resource Center, Supervisor)Event and Panel Coordinator

Panelists:

• Justin Alfred : Southern University and A&M College, Baton Rouge. Civil Engineering / Computer science. Lockheed Martin.
• Joseph Bertrand ‘20 : Alumni : North Carolina Agricultural and Technical State University, Associate Engineer at Caterpillar Inc.
• Darryl Burrell Jr. : Alumni :Morgan State University . Project manager at city of Pearland, Texas engineering and Public Works.
• Dr. Garry J. Kennebrew Jr. ‘04 : MAJ, US Army Reserve. Emergency Medicine Physician . Hospitals of Providence. University Medical Center of El Paso. Studied …

Daily Eastern News: February 04, 2026, Eastern Illinois University

Daily Eastern News: 2025-2026

No abstract provided.

Daily Eastern News: March 04, 2026, Eastern Illinois University

Daily Eastern News: 2025-2026

No abstract provided.

Gmp-Compatible Fluoropolymer Closed Culture Systems For Manufacturing And Controlled Aggregation Of Stem Cell-Derived Pancreatic Progenitors For Diabetes Cell Therapy, Praveen Pedabaliyarasimhuni, Balaji Ramachandran, Will Yoon, Demetry Prezelj, Lyne Khair, Nicolas Drolet, Katie Campbell, Corinne A Hoesli

Advancing Manufacture of Cell and Gene Therapies IX [2026]

Please click Additional Files below to see the full abstract

Statistical Guarantees Of Deep Generative Models Involving Diverse Spaces: Generation Consistency And Robustness, Anish Chakrabarty

Doctoral Theses

Generative modeling focuses on the task of producing new data samples that closely resemble those drawn from an original, unknown distribution. Despite being well-known in statistical estimation theory, the approach has gained substantial traction in recent years, driven by groundbreaking results in areas such as image synthesis, natural language generation, and network modeling. The complexity of modern-era data domains and the ensuing adaptations that suitable models must undergo have presented new challenges. These advances raise several fundamental questions, the first of which is: When do generative models accurately approximate the true data distribution? One may also ask: How well do …

Civic Center Curriculum Committee Agenda February 4, 2026, Utah State University

Educational Policies Committee

• Call to Order
• New Business
• Rubric Grading Guidelines
• Assessable Language
• Creative Arts
• Social Science
• Life and Physical Science
• Adjourn: 10:30 am

Sb14-2526: Resolution Establishing The Online Student Ad Hoc Committee, Alexis Beckman-Gomez, Emma Despain, Buddy Wilson

Senate Resolutions, 2007-Present

SB14-2526: Resolution Establishing the Online Student Ad Hoc Committee. This resolution passed a RCV [14-2-0] during the February 4, 2026 meeting of the Associated Students of the University of Montana (ASUM).

Cash Or Crash: Return To Player Percentages And Expected Value Of Crash Games, Robert H. Scott Iii, Mikhail M. Sher, Jonathan Daigle

UNLV Gaming Research & Review Journal

Crash games are a new type of casino game offered on some online gambling sites. The first crash game was created by the online cryptocurrency casino Bustabit. Other cryptocurrency casinos started offering their own versions of crash games. Now mainstream online casinos have developed their own crash games—notably Rocket by DraftKings. Crash games are easy to learn and play. They offer the opportunity to increase your bet by many hundreds of multiples—though, as we show when deriving expected values, these outcomes are rare. In this paper, we study the history of crash games and calculate theoretical values of crash game …

Quality Assurance Memorandum For Year 2022 Estuarine Grab Data, Lara M. Martin

PREP Reports & Publications

No abstract provided.

Mitigating Salmonella In Poultry Using Probiotics: Mechanisms, Challenges, And Opportunities, Oluwaseun D. Adeyemi, Samuel N. Nahashon

Food and Animal Sciences Faculty Research

The global poultry industry continues to face significant challenges due to Salmonella infections, which pose severe public health concerns and economic losses. Recently, the reemergence of antimicrobial resistance has led to the restriction of antibiotic use in poultry, especially as growth promoters, thus accelerating the search for sustainable alternatives. Among these, probiotics have gained attention as potential candidates for improving poultry health and mitigating Salmonella colonization in the gut. This review summarizes the key mechanisms through which probiotics exert anti-Salmonella effects, including competitive exclusion, production of antimicrobial substances, reinforcement of the intestinal barrier, and modulation of host immune responses. Commonly …

Funding Resilience Or Missing The Mark? An Analysis Of Rrf Allocation And Climate Risk Alignment In Italian Municipalities, Giulio Breglia, Mariagrazia D’Angeli, Giacomo Gazzellone

Fondazione Eni Enrico Mattei Working Papers

Natural hazards are an increasing concern, placing disaster preparedness and mitigation at the forefront of policy agendas. In this context, Italy’s Recovery and Resilience Plan (NRRP) has allocated €3 billion for explicit disaster prevention, with a primary focus on hydrogeological risks such as floods and landslides. This study evaluates the geographical and thematic distribution of resilience-related funding, examining whether financial resources have been effectively targeted toward municipalities with the highest exposure to environmental hazards. Using a clustering classification, we identify substantial disparities in the allocation of resilience funds, revealing that municipalities with relatively low risk levels often receive disproportionately high …

February 4, 2026 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

2025-2026 Junior Recital - Liyang Liu (Violin), Li Yang Liu, Sheng Yuan Kuan, Nabil Hetman

Junior and Senior Recitals

No abstract provided.

Development Of An Aav-Based Gene Therapy For The Ocular Phenotype Of Friedreich's Ataxia., Heyu Tang, Siddhant Gupte, Emily Xu, Kaitlyn R Calabro, Hannah Friend, Sean M Crosson, Diego Fajardo, Zachary Kostamo, Hangning Zhang, James J Peterson, Fangyu Lin, Zbynek Kozmik, Cathleen Lutz, Sanford L Boye, Shannon E Boye

Faculty Research 2026

Friedreich's ataxia (FA) is a leading form of hereditary ataxia caused by autosomal recessive mutations in frataxin (FXN). GAA triplet repeat expansions lead to lower levels of FXN expression, abnormal influx of iron into mitochondria, and damage to the nervous system. Patients typically present before the second decade with loss of muscular function, speech impediments, and cardiomyopathy. At later stages, vision loss typically manifests. Work is under way to develop gene therapies that address the cardiac and CNS manifestations, but their routes of administration do not lead to efficient transduction of the retina. The purpose of this study was to …

Targeting Pediatric Glioblastomas By Combining Olig2 Inhibitor Ct-179 With Fractionated Radiation In A Panel Of Patient-Derived Orthotopic Xenograft Mouse Models., Holly Lindsay, Yuchen Du, Lin Qi, Huiyuan Zhang, Sibo Zhao, Frank K Braun, Mari Kogiso, Clifford Stephan, Gordon Alton, Gregory Stein, Graham Beaton, Santosh Kesari, Steven Neuhauser, Timothy M Stearns, Jeffrey Chuang, Emily L Jocoy, Carol J Bult, Beverly Teicher, Malcolm A Smith, Xiao-Nan Li

Faculty Research 2026

The poor clinical outcomes of pediatric high-grade glioma (pHGG) highlight the urgent need for new therapies. Oligodendrocyte lineage transcription factor 2 (OLIG2) is a pro-mitotic transcription factor highly expressed in glioma stem cells and may represent a novel therapeutic target. To evaluate the therapeutic efficacy of an OLIG2 inhibitor CT-179 in pHGG, we determined the OLIG2 mRNA expression in 10 patient-derived orthotopic xenograft (PDOX) models. In vitro activities of CT-179 were analyzed in monolayer and neurosphere cells (0–10 µM) with and without radiation (XRT) (0–8 Gy), brain penetration was evaluated in tumor-bearing PDOX mice, and in vivo efficacy was determined …

Targeting Pediatric Glioblastomas By Combining Olig2 Inhibitor Ct-179 With Fractionated Radiation In A Panel Of Patient-Derived Orthotopic Xenograft Mouse Models., Holly Lindsay, Yuchen Du, Lin Qi, Huiyuan Zhang, Sibo Zhao, Frank K Braun, Mari Kogiso, Clifford Stephan, Gordon Alton, Gregory Stein, Graham Beaton, Santosh Kesari, Steven Neuhauser, Timothy M Stearns, Jeffrey Chuang, Emily L Jocoy, Carol J Bult, Beverly Teicher, Malcolm A Smith, Xiao-Nan Li

Faculty Research 2026

The poor clinical outcomes of pediatric high-grade glioma (pHGG) highlight the urgent need for new therapies. Oligodendrocyte lineage transcription factor 2 (OLIG2) is a pro-mitotic transcription factor highly expressed in glioma stem cells and may represent a novel therapeutic target. To evaluate the therapeutic efficacy of an OLIG2 inhibitor CT-179 in pHGG, we determined the OLIG2 mRNA expression in 10 patient-derived orthotopic xenograft (PDOX) models. In vitro activities of CT-179 were analyzed in monolayer and neurosphere cells (0–10 µM) with and without radiation (XRT) (0–8 Gy), brain penetration was evaluated in tumor-bearing PDOX mice, and in vivo efficacy was determined …

Development Of An Aav-Based Gene Therapy For The Ocular Phenotype Of Friedreich's Ataxia., Heyu Tang, Siddhant Gupte, Emily Xu, Kaitlyn R Calabro, Hannah Friend, Sean M Crosson, Diego Fajardo, Zachary Kostamo, Hangning Zhang, James J Peterson, Fangyu Lin, Zbynek Kozmik, Cathleen Lutz, Sanford L Boye, Shannon E Boye

Faculty Research 2026

Friedreich's ataxia (FA) is a leading form of hereditary ataxia caused by autosomal recessive mutations in frataxin (FXN). GAA triplet repeat expansions lead to lower levels of FXN expression, abnormal influx of iron into mitochondria, and damage to the nervous system. Patients typically present before the second decade with loss of muscular function, speech impediments, and cardiomyopathy. At later stages, vision loss typically manifests. Work is under way to develop gene therapies that address the cardiac and CNS manifestations, but their routes of administration do not lead to efficient transduction of the retina. The purpose of this study was to …

Allepichian Aldrich V. Attorney General United States Of America

2026 Decisions

USDC for the Eastern District of Pennsylvania

East Tennessee State University, February 2026, Tennessee. Comptroller Of The Treasury.

Financial and Compliance Audit Reports

No abstract provided.

Commonwealth Times 2026-02-04

Commonwealth Times, 1969-

No abstract provided.

Fs Faculty Rights And Responsibilities Committee Minutes 2026-02-04, Northern Illinois University

Faculty Senate Archives

No abstract provided.

On The Need Of Pluralism And Common Ground In Sla, Simona Pekarek Doehler, Steven L. Thorne, Soren W. Eskildsen, Marije C. Michel

World Languages and Literatures Faculty Publications and Presentations

Hyperbolic claims that SLA is in crisis (!), that a unifying theory is overdue, or that research must be oriented toward pedagogy have resurfaced once again—most recently in the response by Lantolf et al. (2025) to the Special Issue on Synergies in Second Language Acquisition and Teaching (SLA/T) (Atkinson et al., 2025). Our own position is diametrically opposed to such claims.

Theoretical And Conceptual Approaches To Journalism Education, August E. Grant, Jeffrey S. Wilkinson, G. Nathan Carnes

Faculty Publications

Many journalism programs embrace the teaching hospital model because of its practical approach, employing working journalists as journalism educators. However, critics contend a more conceptual model of journalism education is needed. This essay explores the literature on journalism education models and seeks to integrate the teaching hospital and entrepreneurial journalism approaches with the revised Bloom's Taxonomy and Fink's Taxonomy of Significant Learning. Combined, these models provide a solid theoretical foundation for practical, applied journalism education. This essay applies these four models to journalism education, yielding a matrix of dimensions that can guide the creation or modification of curricula as well …

Control-By-Interconnection Beyond Casimirs And Connections To Ida-Pbc, Joel Ferguson, Pablo Borja

School of Engineering, Computing and Mathematics

Control by Interconnection (CbI) and Interconnection and Damping Assignment Passivity-Based Control (IDA-PBC) are two nonlinear design methodologies that exploit passivity to construct stabilising controllers. While CbI is known to be a subset of IDA-PBC, the converse link has remained open. This paper revisits CbI by utilising dynamic invariants beyond Casimirs and a more general control structure. Using this more general structure we show a one-to-one correspondence between IDA-PBC and CbI controllers for the class of mechanical systems without friction.

Lindenwood Digest, February 4, 2026, Lindenwood University

Lindenwood Digest

• Primary Figures: James Hutson; Colleen Biri; Mike Marzano; Ronda Cypret-Mahach; Meredith Marsh; Jessica Loyd; Lilliann Cheek; Kay DeKock; Michiko Nohara-LeClair; Esther Murphy; Jarret Brueck; Tim McNamee; Katie Long; Brad Hansen; Kim Diehl de Yanes.

• Key Events: The university issued a call for five faculty award nominations; four academic programs launched a pilot for AI and Emerging Technology Literacy; the "Lions Living Well" wellness program transitioned to the myHC360+ platform; researchers initiated recruitment for a probiotic gut health study and a gender perception study; the LARC opened a 250th American independence anniversary book display. 

• Date/Location: February 4, 2026; …

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Comparison Of Surgical Treatment Patterns And Temporal Trends For Stage I-Iii Invasive Rectal Adenocarcinoma Among Regions In The United States, Whitney Elks, Declan Feery, Celina Cosme, Kavita Batra, Lance Horner, Charles St Hill, Ovunc Bardakcioglu

School of Medicine Faculty Research

Background: Practice patterns of surgical management of rectal adenocarcinoma vary among US regions. Nationwide, there has been an overall trend toward the performance of anterior resection (AR) over abdominoperineal resection (APR) in the surgical management of invasive rectal adenocarcinoma when feasible. It is suspected that this trend is adopted at a slower rate in underserved regions of the United States. Methods: Data from the NCDB for 2004–2019 was queried for patients with stage I-III rectal adenocarcinoma who underwent anterior resection (AR) or abdominoperineal resection (APR). Comparisons of AR versus APR were made among year, region, approach, and stage. Results: Of …

Competitive Advantage Strategies For Independent Restaurant Owners, Bobby Mccrary

Walden Dissertations and Doctoral Studies

Independent restaurant owners often face challenges in achieving a sustainable competitive advantage, resulting in poor business performance and loss of profitability. Identifying practical competitive advantage strategies is essential for independent restaurant owners to surpass five years of business operations. Grounded in resource-based view theory, the purpose of this multiple case study was to explore effective competitive advantage strategies independent restaurant owners used to sustain operations beyond five years. Purposeful sampling was used to select four independent restaurant owners located in Wichita, Kansas, who sustained operations beyond five years through competitive advantage strategies. Data were collected from semistructured interviews and from …

Multimodal Education To Improve Metabolic Monitoring Knowledge Among Psychiatric Nurse Practitioners, Tania Alfonso

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) staff education project was a multimodal educational intervention to improve outpatient psychiatric nurse practitioner (PNP) knowledge of metabolic monitoring guidelines for patients prescribed second-generation antipsychotics (SGAs). The project addressed low adherence to national monitoring standards that contribute to increased cardiometabolic risks associated with SGAs. The project question was: Does staff education regarding metabolic monitoring guidelines improve nursing knowledge as compared pre- to posteducation? The purpose was to enhance PNP knowledge of metabolic monitoring guidelines. Guided by the Johns Hopkins evidence-based practice (JHEBP) model, I conducted a focused literature search and identified 28 peer-reviewed articles …