Digital Commons Network^™

Legislating Infrastructure: A State-Level Model To Accelerate Endometriosis Research And Women's Health Equity., E T Courtois, L Roy, Jasmina Uvalic, K Mullaj, D Lockshire, D E Luciano

Faculty Research 2026

Impact statement: A legislatively mandated, statewide endometriosis biorepository integrated within a multidisciplinary endometriosis focused program demonstrates how policy-driven infrastructure can integrate education, clinical care, harmonized biobanking, and translational research to address persistent gaps in women's health in the long term. The Connecticut Endometriosis Working Group (EWG), a group of legislators, researchers, patients, health care providers, and advocates, was established in 2021. The EWG met monthly to discuss strategies to address endometriosis and propose endometriosis specific legislation which has been a turning point. Public Acts 22-33 and 23-67 directed the establishment, governance, and annual reporting of a coordinated endometriosis data and …

Integration Of A Neuronal Rnaseq Dataset With The Draft Gryllus Bimaculatus Transcriptome Refines Gene Predictions And Highlights Potential Systematic Response To Injury., Felicia F Wang, Harrison P Fisher, Lisa M Ledwidge, Joel H Graber, Riley A Grindle, Jarod A Rollins, Hadley W Horch

Faculty Research 2026

The cricket Gryllus bimaculatus presents a compelling model for investigating neuroplasticity due to its unusual capability of adult structural reorganization. The molecular pathways underlying these changes remain poorly understood. Here, we reanalyzed RNAseq data, originally collected from deafferented and control prothoracic ganglia one, three, and seven days post-injury, which had previously been used to assemble a de novo transcriptome. In this current analysis, we aligned our original RNAseq data to the publicly available G. bimaculatus draft genome, and used the resulting alignments to refine and update the existing annotations. The integration added 3,868 novel genes, 9,172 new transcript isoforms including …

Identifying Transcriptomic Signatures That Mediate The Causal Effect Of Genotype On Alzheimer's Disease., Simran Kaur, Anna L. Tyler, Giovanna L Durante, Gregory Cary, Gregory W. Carter, J Matthew Mahoney

Faculty Research 2026

The combined effects of thousands of genetic polymorphisms account for Alzheimer's disease (AD) genetic risk. Most AD polymorphisms affect gene expression. Thus, the transcriptome, the set of all gene expression levels for every gene in the genome, is a major mediator between the genotype to phenotype. This study uses genotypes, transcriptomes, and clinical phenotypes to identify the transcriptomic signature that mediates the causal effect of genotype on AD. By utilizing a causal inference method known as high dimensional mediation analysis (HDMA) on the Religious Orders Study/Memory and Aging Project (ROSMAP) longitudinal cohort, the genotype, transcriptome, and phenotype data were reduced …

Can Angiotensin Ii Affect The Inflammatory Response Of Human Dental Pulp Cells In Vitro?, Bella Luna Colombini-Ishikiriama, Thiago José Dionisio, Thais Francini Garbieri, Rafaela Alves Da Silva, Sandra Helena Penha Oliveira, Vanessa Soares Lara, Andrew S Greene, Carlos Ferreira Dos Santos

Faculty Research 2026

OBJECTIVE: This study aimed to evaluate the capacity of fibroblasts from permanent and deciduous dental pulp to express inflammatory mediators when exposed to bacterial and inflammatory antigens. It also sought to assess the presence of components of the renin-angiotensin system (RAS) and the potential modulatory role of ANG-II in this response.

METHODOLOGY: Fibroblasts were cultured from the pulp of permanent and deciduous teeth obtained from three adult and four pediatric donors with informed consent. Cells were stimulated with Porphyromonas gingivalis and Escherichia coli lipopolysaccharides (LPS) either alone or in combination with ANG-II and, in some cases, with IL-1β. Gene expression …

A New Mouse Mutant With A Discrete Mutation In Pcdhgc5 Reveals That The Protocadherin Γc5 Isoform Is Not Essential For Dendrite Arborization In The Cerebral Cortex., Camille M Hanes, David M Steffen, George Murray, Robert W. Burgess, Joshua A Weiner, Andrew M Garrett

Faculty Research 2026

There are ~ 60 clustered protocadherin (cPcdh) isoforms expressed from three gene clusters (Pcdha, Pcdhb, Pcdhg) arrayed in tandem across nearly 1 Mb in mammals. cPcdhs are homophilic cell adhesion molecules (CAMs) critical for a host of neural developmental functions consistent with a role in cell-cell recognition. Indeed, isoforms make recognition modules in combination to generate recognition diversity far exceeding the ~ 60 individual CAMs. However, there is also growing evidence for specialized functions for specific isoforms, particularly the C-type isoforms found at the 3' ends of the Pcdha cluster (αC1 and αC2) and at the 3' end of the …

Editorial: Interdisciplinary Innovations In Car T-Cell Therapy For Autoimmune And Cancer Treatment., Apostolos Zaravinos, Derya Unutmaz, Marko Radic

Faculty Research 2026

No abstract provided.

Genetic Counselors' Perspectives And Experiences With Workplace Genetic Testing: Results Of A National Survey., Alexandra Truhlar, Elizabeth Charnysh, Subhamoy Pal, Jonathan M Reader, Katherine Hendy, W Gregory Feero, Kerry Ryan, Alyx Vogle, Sarah Mccain, Rebecca A Ferber, Jill Furnival, Charles Lee, J Scott Roberts, Wendy R Uhlmann, Kunal Sanghavi, Insight @ Work Consortium

Faculty Research 2026

Purpose

Methods

Results

Il1a Enhances Tnf-Induced Retinal Ganglion Cell Death., Katherine M Andersh, Michael Maclean, Gareth R Howell, Richard T Libby

Faculty Research 2026

Introduction:

A growing body of literature suggests a role for neuroinflammation in retinal ganglion cell (RGC) death in glaucoma. For instance, deficiency of three proinflammatory cytokines, complement component 1, subcomponent q (C1q), interleukin 1 alpha (Il1a), and tumor necrosis factor (Tnf), resulted in significant protection of RGCs after glaucoma-relevant insults. While TNF and C1Q have been extensively investigated in glaucoma-relevant model systems, the role of IL1A in RGCs is not well defined.

Methods:

Eyes of 2–4 month-old C57BL/6J mice or mice deficient in either Jun or Sarm1 were intravitreally injected with IL1A alone, TNF …

Editorial: Interdisciplinary Innovations In Car T-Cell Therapy For Autoimmune And Cancer Treatment., Apostolos Zaravinos, Derya Unutmaz, Marko Radic

Faculty Research 2026

No abstract provided.

False Idols In The Early History Of International Taxation, Wei Cui

All Faculty Publications

A careful reading of recent scholarship on the early history of international taxation, especially on the League of Nations ’ work on ‘ double taxation ’ , ought to have dislodged many myths about this history. But more often than not, such scholarship is taken to offer mere details without altering our fundamental understanding. This chapter suggests that this reception refl ects a longstanding pattern in discourses about international taxation: participants perpetuate or cling onto narratives that are easily seen to be false. The chapter exposes this pattern by summarising evidence for four rarely-acknowledged conclusions about the League ’ s …

Race And Racism In Canada’S Immigration Detention System, Efrat Arbel, Prasanna Balasundaram, Hanna Gros, Nana Yanful

All Faculty Publications

Race and Racism in Canada's Immigration Detention System is the first comprehensive, independent study to examine race and racism in Canada's immigration detention system. Grounded in rigorous legal analysis and qualitative research, the study draws on interviews with 50 participants, including people with lived experience of immigration detention, as well as lawyers, paralegals, and service providers who work in immigration detention. The research was guided by an advisory board of people with lived-experience in immigration detention and co-led by a collaborative research team.

Call Off The Dogs: Rethinking Sniffer Dog Searches In Canadian Criminal Law, Sara Gordon

All Faculty Publications

The Supreme Court of Canada has repeatedly held that police sniffer dog searches are Charter-compliant based on a low standard of reasonable suspicion because they are minimally intrusive, narrowly targeted, and can be highly accurate. Since the Court last considered their constitutionality, however, extensive empirical research has fundamentally challenged assumptions about the reliability and accuracy of police sniffer dogs, as well as the harm to individuals subjected to these searches. Moreover, the phenomenon of handler cueing can operate to transmit a police officer’s unconscious biases—even those they would consciously reject—to their dogs, further reducing accuracy and leading to false alerts …

Bloodstain Pattern Analysis And The Gatekeeping Role Of Canadian Courts, Sara Gordon

All Faculty Publications

Despite its long history of admission throughout North America, there appears to be no published Canadian case subjecting bloodstain pattern analysis to the special scrutiny Canadian law demands for novel or contested scientific evidence. Instead, courts have admitted the evidence based largely on the training and experience of forensic examiners, taking it for granted that the field is sufficiently reliable. However, the application of the White Burgess framework reveals that there are serious and severe concerns about the underlying scientific validity of the technique which should render it generally inadmissible. At Stage One of White Burgess, bloodstain pattern analysis fails …

Model Law? Template Legal Culture And The Global Production Of Environmental Law, Natasha Affolder

All Faculty Publications

Lawyers build from templates. Accounts of how law is made rarely mention them. New legislation tends to present itself as original. It is almost never made from scratch. This article makes the hidden process visible. It does so through a study of the near-global spread of environmental impact assessment (EIA) legislation since 1969, using computer-assisted textual similarity analysis to trace what I expected to be identifiable model laws and clear lines of legal inheritance. The search yielded instead a transnational repertoire of legal fragments, repeatedly recombined into new legislative forms across different legal traditions, languages and decades. EIA's legislative spread …

Good Faith And Certainty In Contract Law, Marcus Moore

All Faculty Publications

Does a general principle of good faith create too much uncertainty in  Contract Law? This article provides in-depth consideration of the controversy around this question.Reviewing a number of common arguments and reasonswhy good faith is said to be too uncertain, and responses to these, the article finds a complex picture rather than a simple answer. Recent Canadian experience with recognising a general principle of good faith in contractual performance suggests that at least two further details are critical to the potential for uncertainty: first, whether good faith operates as a freestanding duty or instead functions as a unifying principle that …

Wilson, Issue 02, 2025-26, University Of Northern Iowa. Wilson College Of Business.

Wilson

Contents:

From the Dean --- 3
Auditing Students Learn Emerging Technologies and Real-World Analysis --- 4
How Real Estate Students are Learning Industry Software in the Classroom --- 8
Marketing in the Age of Data --- 14
Building Communities, Shaping Futures --- 18
Data Drives Business Success for UNI Student Entrepreneurs --- 22
Data to Assist in Iowa Stomr Response --- 23
Ethical Considerations of Data Breaches --- 24
How Ethics and Data Management Intersect In Today's Business Climate --- 26
Students Dominate Advertising Competition --- 28
AACSB Supplemental Accounting Accreditation --- 30
A New Era for Business: UNI's Wilson …

Maine Law Magazine - Issue No. 100, University Of Maine School Of Law

Maine Law Magazine

Features

• Maine Law’s Privacy Program Continues to Innovate
  How Maine Law’s privacy and innovation programs are preparing students for emerging legal challenges.

• New Business & Law Clinic
  Strengthening Maine’s economy one startup at a time.

• Global Experiential Learning
  From the Arctic Circle to U.N. climate negotiations, students engage with environmental law where it happens.

• Rural Access to Justice
  The Rural Practice Clinic’s impact on Maine’s growing justice gap.

• Law & Conservation Efforts
  How Maine Law alumni steward change and safeguard the future through environmental advocacy.

• Supporting Maine’s Vulnerable
  The Refugee & Human Rights Clinic expands access to justice across Maine. …

Holding Space For Teachers: A Phenomenological Exploration Of Social-Emotional Competence And School Climate In Title I Schools, Zsa Zsa B. Davis

College of Graduate Studies: Theses & Dissertations

Teacher retention remains a critical concern in education, particularly within Title I schools, where educators face elevated stress levels, emotional exhaustion, and burnout due to the complex needs of students and limited institutional resources. Addressing teachers’ social-emotional competence (SEC) can mitigate the adverse effects of stress by enhancing emotional regulation, well-being, and relational trust which in turn promote job satisfaction and professional fulfillment. Likewise, a positive school climate plays a crucial role in sustaining teachers’ long-term commitment to the profession. This qualitative study employed a descriptive phenomenological design to explore the lived experiences of Title I elementary teachers as they …

Community Care During Austerity: Mutual Aid And Online Connection Among Disabled Americans, Maeve J. King

College of Graduate Studies: Theses & Dissertations

Amidst a mental health epidemic and rising inequality, online communities offer a medium for peer support networks for disabled Americans. Community care, especially in the form of mutual aid, has increased in popularity since the beginning of the COVID-19 pandemic. Considering troubling increases in eugenics-based messaging and disproportionate economic inequality, disabled Americans in particular have leaned into community care. Previous research establishes social media as a hub for resource mobilization and safe space for members of marginalized communities to connect. This research aims to explore the impacts of social, political, and economic unrest on the development of community care and …

Early Icu Physiological Subtyping From Time-Series Data: A Comparative Study Of Feature Complexity, Predictive Performance, And Model Interpretability, Rojeena Khadka

College of Graduate Studies: Theses & Dissertations

Intensive Care Unit (ICU) patients do not follow a single uniform physiological pattern. Patients admitted with the same diagnosis show different clinical trajectories over time making standardized classification and treatment approaches insufficient. The increasing availability of large-scale electronic health records in MIMIC-IV makes it possible to investigate such heterogeneity through data-driven approach that captures how physiology evolves during the early phase of ICU admission. This thesis compares two analytical pipelines designed to identify physiological subtypes from the first 48 hours of ICU time series data. This study then assesses how well these subtypes predict in-hospital mortality. The first approach, referred …

Effects Of The Menstrual Cycle Phase On Rpe, And Symptom Characteristics In Pre-Professional Female Soccer Players, Emily Potts

College of Graduate Studies: Theses & Dissertations

Hormonal fluctuations across the distinct phases of the menstrual cycle have been shown to influence physiological and psychological responses to exercise, with some evidence suggesting phase-dependent changes in symptom presentation and ratings of perceived exertion (RPE); however, findings remain inconsistent, and few studies have examined these relationships across an entire competitive season in female soccer players. The purpose of this study was to examine changes in RPE and menstrual symptoms across cycle phases, as well as the relationships between RPE and symptom reporting in pre-professional female soccer players. A total of 22 female soccer players (age 22± 1.85) were recruited …

Body Image Perception In African American Women, Ages 20-55 Years, Trina Suttles

College of Graduate Studies: Theses & Dissertations

This qualitative study explored the factors that influence body image perception among African American women in the metropolitan Atlanta, Georgia area and examined how these perceptions shape physical activity and dietary behaviors. Body image perception is a critical psychocultural factor influencing obesity-related behaviors, particularly among African American women who navigate culturally specific beauty standards and health beliefs. Guided by the Socioecological Model, this study addressed three research questions: (1) how African American women perceive their body image, (2) how these perceptions influence health behaviors, and (3) what multilevel factors shape body image perceptions. This study employed consensual qualitative research (CQR) …

Effect Of Elemental Additions On The Microstructure, Macrostructure, And Mechanical Properties Of Gray Iron, August E. Rautmann

College of Graduate Studies: Theses & Dissertations

Gray iron is composed primarily of an iron matrix and flake graphite, with the higher percentage of volume taken up by the iron matrix. The iron matrix is the transformation product of austenite, and this prior austenite structure is understood to affect the final grain structure. Grain structure affects the properties of a metal, with a finer structure recognized as beneficial for most properties. Thus, the refinement of austenite structure has potential in improving the material properties of gray iron. This study aims to advance the limited knowledge about the control of austenite grain size via elemental additions. Building off …

"Spectrum", Mackinzey H. Critzer

College of Graduate Studies: Theses & Dissertations

These body of works explores themes centered around ASD/Autism Spectrum Disorder, including symptoms involved, my personal views/experiences of it, social issues, and other related topics. My work consists of various mediums, digital pieces/prints and physical installations that involve bright color tones, human/humanoid figures, and various symbols.

Disrupting Ableist And Heteronormative Narratives Through The Other-Abled Body In Octavia E. Butler's "The Evening And The Morning And The Night", Morayo Joy Akingbelue

College of Graduate Studies: Theses & Dissertations

Ableist discourse has historically positioned disabled people as ‘unfit,’ resulting in their marginalization within society. This marginalization is not only manifested in terms of their physical performance but sometimes in the way disability intersects with race, gender, and sexuality, reinforcing the construction of disabled individuals as ‘other.’ While prominent feminist and disability scholars have challenged deficit based narratives of disability, Rosemarie Garland-Thomson’s concept of the misfit, Sami Schalk’s Defamiliarization, John Swain and Sally French’s Affirmative Theory, and Moya Bailey and Izetta Autumn Mobley’s A Black Feminist Disability Framework, Black women’s speculative fiction, offers a critical intervention by defamiliarizing dominant narratives …

Revised Microbiology Core Knowledge Objectives For Modern Undergraduate Medical Education, Timothy J. Bauler, Cindy G. Arvidson, Samina Akbar, Dennis N. Arvidson, Margaret E. Bauer, Dwayne M. Baxa, Rebecca J. Greenblatt, Kerstin Honer Zu Bentrup, Yingguang Liu, Inaia Phoenix, Julie A. Kerry

Department of Biomedical and Translational Sciences Faculty Publications

Defining the core content for each scientific discipline in a modern preclinical medical education curriculum is critical to ensure optimal student learning and application of foundational knowledge for clinical practice. Attendees of the Association of Medical School Microbiology and Immunology Chairs (AMSMIC) Educational Strategies Workshop recently highlighted the need for updated medical microbiology learning objectives, given the shift in medical education toward less time for preclinical coursework and more integrated learning. Herein, we describe the process of developing a comprehensive, educator-driven set of knowledge objectives for medical microbiology. These objectives emphasize common pathogens, as well as pathogens associated with severe …

Evaluating Source Material And Seed Propagation Techniques For Spartina Alterniflora To Enhance Salt Marsh Restoration In Coastal Georgia, Maygan Palacios

College of Graduate Studies: Theses & Dissertations

Salt marshes provide critical ecosystem services, including carbon sequestration, flood attenuation, and habitat for diverse aquatic and terrestrial species. Despite their ecological importance, these habitats are increasingly threatened by anthropogenic activities and rising sea levels. To protect and restore salt marshes and their ecosystem services, restoration efforts using living shorelines (LS) have become more common. Along the Eastern and Gulf coasts of the United States, the native grass Spartina alterniflora is commonly used in LS installations for its key role in salt marsh food webs, resilience to abiotic stress, and ability to stabilize and build sediment. Previous studies have documented …

Factorial Design: A New Look Through Overlap Measures, Sarah W. Liebenow

College of Graduate Studies: Theses & Dissertations

Traditional factorial analysis often relies on ANOVA, which assumes normality and equal variances. This thesis presents a nonparametric approach for assessing main and interaction effects in a 2 × 2 factorial design using the overlap coefficient, estimated through kernel density methods. A bootstrap procedure is used to approximate its sampling distribution for hypothesis testing. Simulation studies compare the overlap-based test with the ANOVA F-test, permutation F-test, and the Kruskal–Wallis test under heteroskedasticity and non-normal conditions. Results show that the overlap measure is highly sensitive to differences in spread and shape, detecting effects that traditional methods frequently miss.

Gauge-Invariant Gravitational Wave Polarization In Metric F(R) Gravity With Cosmological Implications, Ramesh Radhakrishnan, David Mcnutt, Delaram Mirfendereski, Alejandro Pinero, Eric Davis, William Julius, Gerald Cleaver

Physics & Astronomy Faculty Publications

We develop a fully gauge-invariant analysis of gravitational-wave polarizations in metric 𝑓⁡(𝑅) gravity with a particular focus on the modified Starobinsky model 𝑓⁡(𝑅) =𝑅 +𝛼⁢𝑅2 −2⁢Λ, whose constant-curvature solution 𝑅𝑑 =4⁢Λ provides a natural de Sitter background for both early- and late-time cosmology. Linearizing the field equations around this background, we derive the Klein–Gordon equation for the curvature perturbation 𝛿⁢𝑅 and show that the scalar propagating mode acquires a mass 𝑚2𝜓 =1/(6⁢𝛼), highlighting how the same scalar degree of freedom governs inflationary dynamics at high curvature and the propagation of gravitational waves in the current accelerating Universe. Using the scalar–vector–tensor …

Discern Magazine Fall 2026 Excerpt About New Faculty Hires, Santa Clara Law

Historical and Topical Legal Documents

No abstract provided.