Digital Commons Network^™

The Perk Signaling Pathway As A Marker Of The Unfolded Protein Response In Patients With Acute Myeloid Leukemia, Nergi̇z Erkut, Turhan Köksal, Seli̇m Demi̇r, Ahmet Menteşe, Özlen Balta, Mehmet Sönmez

Turkish Journal of Medical Sciences

Background/aim: The protein kinase RNA-like endoplasmic reticulum kinase (PERK) pathway plays a critical role in preventing the accumulation of misfolded or unfolded proteins within the endoplasmic reticulum. In this study, the role of the PERK signaling pathway was evaluated in newly diagnosed, treatment-naïve patients with acute myeloid leukemia (AML).

Materials and methods: Plasma levels of eukaryotic translation initiation factor 2-alpha kinase 3 (eIF2AK3), glucose-regulated protein 78 (GRP78), activating transcription factor 6 (ATF6), CCAAT/enhancer-binding protein homologous protein (CHOP), hypoxia-inducible factor-1 alpha (HIF-1α), and caspase 3 were measured by enzyme-linked immunosorbent assay in peripheral blood samples obtained from AML patients and healthy …

Creating A Healthy Workplace Culture With A “Steps To Wellness” Initiative, Jennifer M. Clifton, Michael Caserta, Cheryl Armstrong, Katarina Friberg-Felsted, Jennifer Macali, Sara Simonsen

Creating Healthy Work Environments (CHWE)

Purpose: The aim of this project was to promote the health and wellness of nursing academia faculty and staff by implementing a physical movement initiative.

Background: Promoting the health and wellness of faculty and staff working in nursing academia is an important and timely initiative (Amaya et al., 2019; Mabona et al., 2022). Researchers have noted that an individual's lifestyle behaviors directly affect their work productivity, physical activity, and stress levels (Labrague et al., 2022; Reif et al., 2020; Stanulewicz et al., 2020). Amaya et al. (2019) suggested that institutions of higher education could improve work-life balance by “creating campus …

From Informal Into Collective Urban Farming: Investigating Potentials In Local Communities In Al Ain, Uae, Nour Khaled Mousa

Thesis/ Dissertation Defenses

By 2050, the world’s population is expected to grow from 7.9 to 9.7 billion. Therefore, collective urban farming is considered to be a practical way to deal with the rising food needs in the limited available urban land which will result in strengthening the local food security and reducing the dependence on imported goods. When farming activities are transformed from random and informal into collective and well-managed spaces more benefits will be brought into a community including social cohesion, education and skills, and better economic opportunities. Collective urban farming is very important to the environment as it delivers multiple ecosystem …

Green Vessel Signal On Multicolor Imaging As An Early Sign Of Ischemic Vasculitis In Irvan Syndrome: A Case Report, Daniel M. Markowitz, Jirat Nimworaphan, Carl Regillo, James P. Dunn, Robert C. Sergott

Wills Eye Hospital Papers

PURPOSE: Idiopathic retinitis, vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome is typically diagnosed after characteristic intravenous fluorescein angiography (IVFA) findings develop. This case demonstrates that identifying a green intravascular and perivascular signal on multicolor fundus imaging may be a potential noninvasive imaging sign for ischemic retinal vasculitis in IRVAN.

OBSERVATIONS: A 55-year-old female presented with bilateral optic disc edema and subtle peripapillary retinal vascular changes. Multicolor imaging showed a distinct green intravascular and perivascular signal before undergoing IVFA evaluation. Subsequent IVFA ultimately showed peripheral capillary nonperfusion, microaneurysms, and leakage consistent with IRVAN.

CONCLUSIONS AND IMPORTANCE: This case demonstrates the potential utility …

University Of Dayton To Hold Conversation On Creativity, The Black Excellence, Civil Rights Movement, University Of Dayton

News Releases

Local artist Bing Davis and University of Dayton alumnus Jack Marchbanks will hold a conversation on creativity, Black excellence and the civil rights movement at 6 p.m. Thursday, Feb. 19, in Sears Recital Hall. It is free and open to the public.

Human Rights Center Program Director Named To African Committee Of Experts, University Of Dayton

News Releases

The Gambian government announced the election of University of Dayton research professor of law and UD Human Rights Center Director of Programs Satang Nabaneh to the African Committee of Experts on the Rights and Welfare of the Child.

Design, Fabrication, And Control Of A New Ceramic 3d Printer, Sam Choppala, Armin Allam, Zichen Fang, Amir Armani

Faculty Research, Scholarly, and Creative Activity

Ceramic on-demand extrusion (CODE) is a new material extrusion additive manufacturing process for advanced ceramics. Studies have demonstrated capability of CODE in producing ceramic parts with superior mechanical properties. The objective of this study was to develop the next generation of CODE printer. The frame, gantry system, extrusion head, oil tank, and radiation subsystem were designed, fabricated, and controlled. Ceramic slurries were developed and fed to the extruder that prints parts onto a bedplate. Green parts were then subject to postprocessing, including drying, debinding, and sintering. Composites and functionally graded materials were created using CODE to further study the process.

Insights Into The Influence Of The Greenland Ice Sheet On Oceanic Macronutrient Dynamics From Decades Of Historical Data, Xin Huang, Yuanyuan Gu, Hilde Oliver, Dustin Carroll, Thomas Juul-Pedersen, Lorenz Meire, Mark J. Hopwood

Faculty Research, Scholarly, and Creative Activity

Increasing freshwater discharge from the cryosphere has the potential to affect mechanisms that regulate the supply of macronutrients to primary producers in the ocean. Although numerous studies have characterized the biogeochemical effects of freshwater discharge from the Greenland Ice Sheet within fjords, it is unclear to what extent these effects propagate offshore and whether or not seasonal macronutrient availability in Greenland's shelf seas has changed since annual freshwater discharge increased in the mid-1990s. Here, we collate and scrutinize extensive work undertaken over the past century to constrain macronutrient distributions in Greenland's coastal seas. From 1929 to 2022, over 38,000 publicly …

Albumin-Binding Domains In Therapeutic Protein Engineering: A Structural And Computational Perspective On Rational Design, Matthew Argyle, Dallin M. Chipman, Anna Claire Woolley, Bradley C. Bundy, Dennis Della Corte

Faculty Publications

Therapeutic proteins face a critical pharmacokinetic challenge: rapid clearance from circulation limits their clinical efficacy. Albumin-binding domains (ABDs) offer an elegant solution by enabling therapeutic proteins to “hitchhike” on serum albumin’s favorable 19-day half-life through FcRn-mediated recycling. Clinical validation through approved therapeutics like ozoralizumab demonstrates the success of this approach, with preclinical studies showing fusion to an ABD extended half-life to 18 days. This review provides an analysis of ABD-fusion protein design, integrating structural biology, computational prediction, and rational engineering principles. We catalog the major classes of albumin-binding modalities, including bacterial three-helix bundle domains, engineered peptides, antibody-derived binders, and alternative …

Prevalence Of Gout In The Sincan District Of Ankara, Türkiye: A Primary Care-Based Cross-Sectional Study, Riza Can Kardaş, Yasemi̇n Ünsal, Derya Yildirim, Hakan Tüzün, Mustafa Necmi̇ İlhan, Hami̇t Küçük, Abdurrahman Tufan, M. Aki̇f Öztürk

Turkish Journal of Medical Sciences

Background/aim: Gout, the most prevalent form of inflammatory arthritis, has shown a global increase in prevalence; however, data from Türkiye remain scarce, inconsistent, and largely confined to western regions. This study aimed to estimate the prevalence of gout among adults in the Sincan district of Ankara, Türkiye, and to provide updated data from a previously understudied region.

Materials and methods: This cross-sectional, community-based study employed a multistage design. Adults aged ≥18 years who presented to selected family health centers in Sincan between February and June 2023 were screened using a structured questionnaire. Individuals with suspected gout underwent comprehensive clinical evaluation, …

Sarcopenia In Atrial Fibrillation: A Prospective Study, Mehmet Aki̇f Topçuoğlu, Ezgi̇ Yilmaz, Di̇nç Doğan Öge, Ali̇ Nai̇m Ceren, Ridvan Muhammed Adin, Ethem Murat Arsava

Turkish Journal of Medical Sciences

Background/aim: The link between atrial fibrillation (AF) and lean body mass is unclear. This study presents the effects of AF on sarcopenia indices, including ultrasonographic muscle architecture.

Materials and methods: In this study conducted in neurology units, 72 subjects with AF (mean age: 71 ± 11years, 49% female) were compared with 538 without AF (mean age:66±12years; 53% female) in terms of sarcopenia indices [anthropometry; Short Physical Performance Battery (SPPB); hand grip strength (HGS); bioimpedance analysis (BIA) indices; skeletal muscle mass index (SMMI) normalized to weight, height and body mass index (BMI); and phase angle (PhA)]; muscle ultrasonography [thickness, cross-section area …

Levothyroxine Poisoning In Children: A Multicenter Study From Türkiye, Kübra Şen Küçük, Şule Demi̇r, Reyhan Deveci̇ Sevi̇m, Fatma Akgül, Gülşen Yalçin, Öznur Eser, Alkan Bal, Eli̇f Ergi̇n, Sercan Öztürk, Ahmet Anik

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate the clinical features, laboratory findings, treatment approaches, and follow-up strategies employed in the management of pediatric patients with levothyroxine poisoning.

Materials and methods: This multicenter retrospective study included patients aged ≤18 years who presented with acute, single-episode levothyroxine ingestion to the pediatric emergency departments of six tertiary care centers between 2010 and 2023. Clinical data, laboratory findings, symptom onset and severity, and treatment modalities were extracted from medical records. Thyroid function tests (TFTs) were interpreted according to the age-specific reference ranges of each center. Treatment decisions, including gastric decontamination and pharmacologic therapy, were evaluated …

Developing Liposomal And Ethosomal Formulations With Potent Antioxidant And Cytotoxic Effects: Unleashing The Power Of Achillea Millefolium L., Esra Akkol, Sena Akçakaya Mutlu, Gökçe Şeker Karatoprak, Çi̇ğdem Yücel, Selen İlgün, Esra Köngül Şafak, Murat Koç

Turkish Journal of Medical Sciences

Background/aim: Achillea millefolium L., a plant rich in phenolics and flavonoids, has been shown to possess strong antioxidant and cytotoxic properties. However, no pharmaceutical formulations have yet been developed for this plant. This study aimed to create and characterize an A. millefolium extract with high antioxidant and cytotoxic activities.

Materials and methods: A total of 10 extracts were prepared from the plant’s aerial parts using ethanol concentrations ranging from 10% to 99.9%. The DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) radical scavenging tests were used to assess the antioxidant properties of the extracts. Cytotoxic effects were assessed using the MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium …

Neuroendocrine Effects Of Exogenous Adropin Administration On The Hypothalamic Pituitary Testicular Axis In Male Rats, Ersen Eraslan, Ayhan Tanyeli̇, Mustafa Can Güler, Asli Özbek Bi̇lgi̇n, Fazi̇le Nur Eki̇nci̇ Akdemi̇r, Eli̇f Polat, Seli̇m Çomakli, Nezahat Kurt, Tuğba Bal Taştan

Turkish Journal of Medical Sciences

Background/aim: Obesity impairs male fertility through metabolic dysfunction, oxidative stress, and disruption of the hypothalamic– pituitary–testicular (HPT) axis. Adropin (ADR), a peptide hormone whose circulating levels are reduced in obesity, plays emerging roles in metabolic homeostasis; however, its involvement in reproductive endocrine regulation remains unclear. The present study was conducted in healthy, nonobese male rats and aimed to investigate the neuroendocrine and testicular effects of exogenous ADR administration, focusing on circulating reproductive hormones, hypothalamic regulatory peptides, and testicular antioxidant pathways.

Materials and methods: Thirty-two male Wistar rats were randomized into control, sham, low-dose ADR (4 μg/kg/day), and high-dose ADR (40 …

Association Of Mir-34a With Metastatic Progression Through The Foxo3a–Sirt1 Regulatory Axis In Breast Cancer, Banu Şahi̇n, İlker Batuhan Bural, Hüseyi̇n Özcan, Sendegül Yildirim, Gamze Tanriöver, Şükran Burçak Yoldaş

Turkish Journal of Medical Sciences

Background/aim: Breast cancer represents the foremost cause of cancer-related mortality among women worldwide and is characterized by a markedly high metastatic potential, contributing substantially to its clinical severity and poor prognosis. This study aimed to evaluate the interrelationship among silent information regulator (SIRT1), Forkhead box O3a (FoxO3a), and microRNA-34a (miR- 34a), the latter of which promotes apoptosis by suppressing the proliferation, migration, and invasion of breast cancer cells. Specifically, we investigated the tumor microenvironment associated with metastatic progression of malignant primary tumors, the influence of nonmetastatic (benign) tumors, and the potential roles of these proteins in both primary tumor development …

The Indiana Statesman, February 12, 2026, Indiana State University

Student Newspaper

SGA candidates make their case; Clapp & Tesmer; Lancaster & Pekny

Keeping Up With… Graduate Student Research Support Models, Giovanna Colosi

Librarian Publications

Graduate education plays a central role in many institutions’ academic missions and revenue models, yet national data from the Council of Graduate Schools (CGS) indicate that enrollment and application patterns have shifted unevenly over the past decade, varying by discipline, credential type, and institutional context. At the same time, the graduate student population is increasingly diverse in modality and life stage, with more students enrolling part time, studying online or in hybrid formats, and returning mid-career. These changes present significant implications for academic and research libraries, particularly as graduate students’ research needs remain intensive while their schedules and pathways grow …

Navigating Analytical Challenges In Clinical Trials Using The Multiverse Approach, Alexander O. Crenshaw, Nicole Pukay-Martin, Anne Wagner

Faculty Articles

Making decisions regarding data processing and analysis are crucial steps toward extracting insights from data in clinical trials. Trial registries like clinicaltrials.gov promote transparency about these decisions and encourage making them in advance. However, clinical studies often face decisions with multiple reasonable options outside the bounds of preregistration, such as when studies conduct post hoc analyses, deviate from preregistered plans, or simply were not preregistered. Additionally, even a priori decisions often have multiple reasonable options from which to choose. Methods that maximize transparency and minimize bias in such situations are needed. This paper advocates for applying a “multiverse” approach to …

Cosby V. Leslie, 142 Nev. Adv. Op. 11 (Feb. 12, 2026), Madeleine Langhoff

Nevada Supreme Court Summaries

In Cosby v. Leslie, the Nevada Supreme Court held that "intrusion" under NRS 200.364(9) requires entry into a genital or anal opening, meaning conduct lacking such intrusion does not constitute sexual assault under Nevada law.

Gold Standard Ventures (Us) Inc. V. Thorson, 142 Nev. Adv. Op. 10 (Feb. 12, 2026), Lauren Jung

Nevada Supreme Court Summaries

The Court affirmed the district court's dismissal of Orla's petition for judicial review, finding that a party must have an existing personal or property right affected by the challenged decision to have standing. The Court therefore found that Orla had no standing to bring suit.

Profiles Of Two Pioneers, February 12, 2026, Tisa Mason Ed.D.

Heart of a Tiger Columns

No abstract provided.

A Rare And Challenging Polymicrobial Pleural Infection Involving Cupriavidus Pauculus In A Patient With Rheumatoid Arthritis And Multiple Complications, Moiz Ahmed Khan, Syeda Samiya Kamal, Muhammad Muneeb, Summaya Zafar

The University of Louisville Journal of Respiratory Infections

A 58-year-old female with a 15-year history of rheumatoid arthritis (RA) and a history of treatment consisting of methotrexate, hydroxychloroquine, leflunomide, and chronic prednisolone therapy, presented with fever, productive cough, dyspnea, and left leg cellulitis. She developed septic shock complicated by tension pneumothorax requiring emergency thoracostomy and non-ST-elevation myocardial infarction (NSTEMI). Pleural fluid culture grew Cupriavidus pauculus, a rare environmental gram-negative bacillus, alongside Burkholderia cepacia and Candida parapsilosis, indicating polymicrobial infection which was most likely predisposed by patient's immunosuppressed state from RA and prolonged steroid use. Treatment consisted of trimethoprim/sulfamethoxazole, meropenem, fluconazole, and cardiopulmonary support, and culminated in …

Pace O Matic Inc V. Eckert Seamans Cherin & Mellott Llc

2026 Decisions

USDC for the Middle District of Pennsylvania

Shawn Williams V. Robin Nyberg

2026 Decisions

USDC for the Western District of Pennsylvania

Defense Distributed V. Attorney General New Jersey

2026 Decisions

USDC for the District of New Jersey

Pace O Matic Inc V. Eckert Seamans Cherin & Mellott Llc

2026 Decisions

USDC for the Middle District of Pennsylvania

2026 Sullivan County 4-H Presents, Lynn Brewer

UNH Cooperative Extension

No abstract provided.

4-H Presents Textile Scoresheet 2026, Lynn Brewer

UNH Cooperative Extension

No abstract provided.

Public Speaking 2026, Lynn Brewer

UNH Cooperative Extension

No abstract provided.

Demonstration 2026, Lynn Brewer

UNH Cooperative Extension

No abstract provided.