Digital Commons Network^™

3d Reconstruction Of Spatial Transcriptomics With Spatial Pattern Enhanced Graph Convolutional Neural Network, Chen Tang, Yuansheng Zhou, Xue Xiao, Lei Dong, Lei Yu, Qiwei Li, Guanghua Xiao, Lin Xu

Faculty, Staff and Student Publications

Spatially resolved transcriptomics (SRT) is a promising new technology that enables simultaneous analysis of gene expression and spatial information for biomedical research. However, the existing statistical and deep learning algorithms used for analyzing SRT data rely solely on two-dimensional (2D) spatial coordinates, which limits their ability to accurately identify spatial domains, spatially variable genes (SVGs), cell-to-cell communications, and developmental trajectories in a three-dimensional (3D) spatial manner. To address these limitations, we introduced Spa3D, which utilized the anti-leakage Fourier transform and graph convolutional neural network model to reconstruct 3D-based spatial structures from multiple 2D SRT slices. We demonstrate that Spa3D is …

Change Detection In An Electronic Device Using Resonant Frequency Analysis, Alan She

Defensive Publications Series

Detecting internal physical changes in an electronic device (e.g., a smartphone, smart watch, wearable device) may be difficult with some conventional methods, and is often limited to chemical or electrical monitoring that fails to detect structural changes. A system can perform a mechanical resonant frequency analysis using existing hardware components, such as a haptic actuator and one or more sensors (e.g., an accelerometer, a microphone). The haptic actuator can be configured to generate a vibrational stimulus across a range of frequencies, while the sensors can measure the device's corresponding response. This measured response data can be processed to generate a …

Multi-Agent System For Cognitive Work Automation Using An Adversarial Review Panel, Tanmay Kayande, Laura Hartney

Defensive Publications Series

This disclosure describes systems and methods for a multi-agent framework that can automate and scale cognitive work. The framework can, for example, use a cognitive assembly line of specialized computational agents to perform tasks such as research and drafting. A beneficial component could be an adversarial review panel (ARP), which is a multi-agent review system where distinct agent personas critique a generated draft from varied perspectives. The structured feedback from the ARP can be used to automatically iterate on and refine the work product. This approach can improve the intellectual rigor of generated content and reduce the time required for …

Advertising Targeting System For Products Dynamically Synthesized From User Specifications, Lakshmi Kumar Dabbiru, Sneha Sripadaraja Kudli

Defensive Publications Series

Online advertising systems that rely on static product catalogs may have challenges serving advertisements for custom products specified by users in real-time. A technical framework can use an image synthesis engine to generate a product image based on user input, such as text or images. This dynamically generated image may then function as an ad creative. An advertiser targeting module can match the creative to eligible advertisers who may validate the design, for example, through a real-time application programming interface call, and return dynamic metadata like pricing and material options. This system can facilitate the presentation of transactable offers for …

Centralized Qr Trust Repository (Cqtr) With Merchant Name Uniqueness For Fraud Prevention In Qr Code Payments, Alok Roy Mr

Defensive Publications Series

The disclosed systems and methods use a Centralized QR Trust Repository (CQTR) for securing and streamlining merchant onboarding and transaction validation, and to address critical challenges in QR-based payments such as cross-acquirer fraud and counterfeit QR codes system performs transaction validation. At the time of onboarding, merchant details such as merchant or business name, account information, and KYC are collected by client servers and CQTR conducts uniqueness validation to ensure name uniqueness across all acquirers. CQTR performs similarity checks, including fuzzy matching and phonetic analysis and prevents duplicate registrations. After successful validation, CQTR generates and registers unique QR codes static …

Continuous Ambient Microphone Calibration Via Opportunistic Broadband Auditory Icons, Rajeev Nongpiur, Chris Breithaupt

Defensive Publications Series

Performance drift in microphone arrays is often caused by environmental factors such as dust, moisture, and grime accumulating over time. This spectral mismatch degrades the performance of spatial audio algorithms that rely on precise array calibration. To address this limitation, a continuous calibration method is disclosed wherein broadband earcons are opportunistically played through device speakers. Audio responses are recorded by on-device microphones during defined user scenarios. A background model is generated to filter out environmental noise and room reverberation from these recordings. Subsequently, the filtered in-field measurement is compared against a reference factory template to estimate spectral deviation. A calibration …

Thermodynamic Stability Modulates Chaperone-Mediated Disaggregation Of Α-Synuclein Fibrils, Celia Fricke, Antonin Kunka, Rasmus K Norrild, Shuangyan Wang, Thi Lieu Dang, Jonas Folke, Mohammad Shahnawaz, Claudio Soto, Susana Aznar, Anne S Wentink, Bernd Bukau, Alexander K Buell

Faculty, Staff and Student Publications

Aggregation of the intrinsically disordered protein alpha-synuclein into amyloid fibrils and their subsequent intracellular accumulation are hallmark features of several neurodegenerative disorders, including Parkinson's disease, for which no curative treatments currently exist. In this study, we investigate the relationship between fibril morphology, thermodynamic stability, and susceptibility to disaggregation by the human chaperone system comprising HSP70, DNAJB1, and Apg2. By varying assembly conditions and incubation times, we generated alpha-synuclein fibrils with diverse morphological and biochemical properties, including a broad range of thermodynamic stabilities, which we quantified using a chemical depolymerization assay. The chaperone system effectively disaggregated three of the four fibril …

Re: Comment Letter For Draft Clark Tailings Consolidated Waste Management Area (Ctcwma) 2024 Data Summary Report (Dated October 15, 2025), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Assessing The Effects Of Ehealth Literacy And The Area Deprivation Index On Barriers To Electronic Patient Portal Use For Orthopedic Surgery: Cross-Sectional Observational Study, Audrey Lynn Litvak, Nicholas Lin, Kelly Hynes, Jason Strelzow, Jeffrey G Stepan

2020-Current year OA Pubs

BACKGROUND: As electronic patient portals (EPPs) continue to gain popularity and systems transition to online tools for scheduling, communication, and telehealth, patients without access or skills to use these tools may be overlooked.

OBJECTIVE: This study analyzed patient and neighborhood-level factors, including eHealth literacy level and the Area Deprivation Index (ADI), that may limit EPP access for orthopedic surgery.

METHODS: A cross-sectional, survey-based study was performed at a single urban tertiary academic medical center in the United States across foot and ankle, hand and upper extremity, and orthopedic trauma subspecialty clinics from June 21, 2022, to August 12, 2022. Survey …

Partial Threaded Barrel Nut With Hollow Spacing Along Unthreaded Portion Concept, Anonymous

Defensive Publications Series

Current bolts and nuts used to attach vehicle parts experience failure during crash due to bolt over constrained by the nut. New design of barrel nuts to reduce bolt loads under crash events by reducing bolt constraints (more of the bolt shaft can deform) is presented. Update the thread location to be further away from the head and creating a hollow space between the bolt and the nut before the starting of the thread enables bolt to deform more, subsequently reduce shear load, failure risk and keep the integrity of vehicle’s major structures.

Integrated Road Usage Fee Management Within Digital Navigation Systems, Paula Marques

Defensive Publications Series

Digital navigation systems may identify routes with fee-based road segments, such as tolls or vignettes, but may not provide an integrated method for payment. This can result in a fragmented and manual process for drivers with varied and unfamiliar payment systems. A system is described for integrating road usage fee management within a digital navigation service. The system can utilize a route analysis engine to identify fees, a client-side geofencing module on a computing device (e.g., a smartphone, smart watch, wearable device, in-vehicle infotainment system, augmented reality glasses, etc.) To detect a vehicle's entry into a fee-based zone, and a …

Dynamic Ai Agent Orchestration For Nl-To-Sql Query Generation, Janga Aliminati, Manny Sanchez Munoz, Sundeep Narravula, Robin Singh

Defensive Publications Series

Reliably generating accurate structured query language (SQL) queries from natural language (NL) inputs is a difficult task due to challenges such as schema ambiguity, uncertainty regarding table relationships, complex business logic makes, etc. LLM-based solutions are often unable to operate reliably within complex, real-world enterprise environments with complex datasets. This disclosure describes the use of agentic artificial intelligence (AI) for NL-to-SQL query transformations. A semantic data layer leverages a three-tiered model - attributes, entities and cubes. Attributes define dimensions within a table, entities represent a logical view of data, and cubes act as business objects that abstract the complexity of …

Glossary-Augmented Generative Ai For Enterprise Translation, Tanmay Kayande, Deep Raithatha, Akash Dambhare, Pooja Agrawal, Mohith P

Defensive Publications Series

Global enterprise operations can experience inefficiencies and service delays from language-siloed support queues, while generic machine translation tools may lack the context to handle enterprise-specific terminology. A system and method can facilitate multilingual communication by integrating a generative artificial intelligence model within enterprise workflow platforms, such as customer relationship management systems. The framework can programmatically retrieve a curated, enterprise-specific glossary and inject it into a translation prompt sent to the model. This technique grounds the model, instructing it to prioritize an organization's specific lexicon for a given translation. The approach can produce translations that are both linguistically fluent and terminologically …

System For Proactive Intervention And Dual-Mode Data Compliance, Tanmay Kayande, Pooja Agrawal, Akash Dambhare, Mohith P, Deep Raithatha

Defensive Publications Series

Enterprise service platforms can present operational challenges due to reactive support models and compliance risks associated with managing sensitive data, such as personally identifiable information (PII). A dual-function architecture may integrate a proactive intervention engine and an augmented data compliance framework. The intervention engine can analyze real-time data signals from various enterprise systems using an inference layer, such as a large language model, to predict potential user friction points and deliver preventative interventions. Concurrently, the compliance framework can provide a proactive component for detecting potential PII for human-in-the-loop review and an on-demand utility for creating non-destructive, anonymized versions of data …

Mildred Williams Smith

African American Funeral Programs

Program for the memorial service of Mildred Williams Smith, held at Matthew H. Lovett & Son's Funeral Home on January 7, 2026.

Back Cover, Michaela Velleno

.RAW Journal of Art and Design

No abstract provided.

Credits, Michaela Velleno

.RAW Journal of Art and Design

No abstract provided.

Artist Index, Maneli Mianji

.RAW Journal of Art and Design

No abstract provided.

'West Coast Orpheus', Maneli Mianji

.RAW Journal of Art and Design

No abstract provided.

'The Dragon Eye'; 'Walking On The Edge'; 'All Material Scatters'; 'Unfinished Blanket'; & 'Lizard Helmet', Maxwell Rice, Alyssa Shavely, Cezar Gomez, Gabriella Yu, Emily Winters

.RAW Journal of Art and Design

No abstract provided.

'My Skin As A Room'; 'Muscle Memory'; & 'I Remember It Being Brighter', Sarah Tarquin, Addy Cota

.RAW Journal of Art and Design

No abstract provided.

'Road Not Taken' & 'The Ripening', Sierra Hall, Kyra Oh

.RAW Journal of Art and Design

No abstract provided.

'Chop' & 'Simple Life', Owen Isachsen

.RAW Journal of Art and Design

No abstract provided.

'Ethical Hacking', Lillie Turinsky

.RAW Journal of Art and Design

No abstract provided.

'Performers', Colin Pope

.RAW Journal of Art and Design

No abstract provided.

'The Unseen Anguish'; 'The Annunciation'; & 'Emerging', Abigail Gan, Angel Froumis

.RAW Journal of Art and Design

No abstract provided.

'Sweet Nectar' & 'The Songs Of Fish', Yasmin Myers, Julia Hazemoto

.RAW Journal of Art and Design

No abstract provided.

'Kinda Crushing Hard', Erin Robinson

.RAW Journal of Art and Design

No abstract provided.

'Overgrown', Lucas Vergara

.RAW Journal of Art and Design

No abstract provided.

'An Inner Child’S Garden Of Growth' & 'Structures (Labor)', Maria Belén Luzuriaga Abad, Itzel Camarillo-Gonzalez

.RAW Journal of Art and Design

No abstract provided.