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A Phenomenological Exploration Of Lgbtq+ High School Graduates’ Perspectives On Lgbtq+-Related Legislation, Thomas James Foley

Walden Dissertations and Doctoral Studies

Lesbian, gay, bisexual, transgender, queer, and questioning (LGBTQ+) students’ social, emotional, and academic experiences and outcomes are not on par with their non-LGBTQ+ peers. Understanding how LGBTQ+ young adults experienced high school in a state with LGBTQ+-affirmative education legislation provides insight for counselors and educators to identify policies and practices that support positive outcomes for LGBTQ+ students. This qualitative phenomenological study explored how LGBTQ+-identifying high school graduates made meaning of their experiences in school as they related to LGBTQ+-affirmative education legislation. Interpretive phenomenological analysis (IPA) was used for the research methodology and data analysis process. Results included four themes: (a) …

A Suite Of Thermal Switches For Surviving Extreme Thermal Environments In Space, Matthew I. Ralphs, Matt Jensen, Alexis Eames, Matt Sinfield

Space Dynamics Laboratory Publications

Thermal switches are a key enabling technology for spacecraft operating in extreme thermal environments. Whether surviving the lunar night, managing intermittent high-power loads from deep space communication systems, or dealing with other extreme thermal environments, high-performance thermal switches allow critical missions to operate beyond conventional thermal design limits. This paper presents the development, testing, and performance of a suite of passive thermal switches designed for both spacecraft- and subsystem-level thermal control. The suite includes: (1) traditional in-line switch placed between sensitive components and radiators; (2) compact designs suitable for integration into standard bolted joint interfaces to modulate the conductance between …

An Investigation Of A Mach 15 Flow Over A Blunt Wedge Using First-Principles Potential Energy Surfaces: Influence Of Wall Temperature, Paolo Valentini, Zach Davis, Maninder S. Grover, Nicholas J. Bisek

Space Dynamics Laboratory Publications

The simulation of a Mach 15 air flow over a blunt wedge is conducted using the direct molecular simulation (DMS) method. Due to partial dissociation of the air mixture at the imposed free stream conditions, the shock layer contains N₂, O₂, NO, N, and O. All potential energy surfaces (PESs) used to model the various molecular interactions only describe electronic ground states energetics. Thus, no electronic excitation is modeled. An isothermal wall boundary condition is imposed, with full momentum and energy accommodation. Two wall temperatures are considered in this work, namely 1,000 K and 2,000 K. …

Hypersonic Non-Equilibrium Cfd And Dsmc Model Comparisons With The Varda Reentry Capsule, Jack D. Crespo, Paolo Valentini, Ashwin P. Rao, Zach S. Davis

Space Dynamics Laboratory Publications

Nonequilibrium aerothermodynamic modeling of the Varda hypersonic testbed capsule is conducted with direct simulation Monte Carlo (DSMC) and computational fluid dynamics (CFD) solvers. Flowfield properties at the 78 km reentry trajectory point are extracted to compute line of sight spectral radiance using two radiative emission codes, namely HARA and NEQAIR. Computed spectra are compared to spectral radiance measured by an in situ optical emission spectroscopy payload flown on Varda’s W-2 capsule in 2025. Model comparisons to the experimental data reveal discrepancies between the HARA and NEQAIR radiative emission predictions in both overall magnitude and qualitative behavior. NEQAIR was found to …

What’S My Name? Experiences Of Individuals With Traditional Hawaiian Names, Natalya N. Spotkaeff

Walden Dissertations and Doctoral Studies

There is no systematic process of orienting non-Hawaiian educators to Hawaiian culture, as evidenced by name mispronunciation. The purpose of this phenomenological study was to explore the experiences of individuals with traditional Hawaiian first names in a classroom environment. Critical race theory (CRT), especially the concept of microaggressions, was used as the framework for the study. Two research questions guided the study: What are the adult lived experiences with traditional Hawaiian first names encountered in academic settings during childhood? How do adults with traditional Hawaiian first names describe their experiences of race in the classroom? Semistructured interviews were conducted with …

Multidisciplinary Approach To Reducing Healthcare-Associated Infections: A Dnp Project, Jovinsky Jonaldo Eliscard

Walden Dissertations and Doctoral Studies

Healthcare-associated infections are increasingly common in healthcare facilities due to multiple concerns, including negligence, human error, and poor conditions. According to Chuwa (2024), secondary infections are a significant threat to patient safety and wellness, reducing an organization’s ability to realize clinical objectives. The facility is a large healthcare provider operating numerous hospitals and care homes across the United States. The organization continues to report increased infection rates across its branches owing to a lack of standardized infection prevention and control protocols, reducing its efficiency and appeal. Internal audits point to inconsistencies in general sanitation, cleanliness, and hygiene. The organization also …

Atmospheric Waves Experiment (Awe) Thermal Control System: Review Of On-Orbit Performance, Matthew I. Ralphs, Mike Holt

Space Dynamics Laboratory Publications

This paper reviews the Atmospheric Waves Experiment (AWE) detector thermal control system’s (TCS) performance for over two years of operation on the Internation Space Station (ISS). The TCS employs active thermal control for the InGaAs detectors with thermoelectric coolers (TEC). Each of the four detectors are controlled by a dedicated TEC at a nominal setpoint of -30°C, with heat transported away via low-mass, high-conductance pyrolytic graphite sheet (PGS) thermal straps into a nickel-plated copper conductor bar. A bi-directional radiator with Silver Teflon ensures an unobstructed view that can radiate the heat away to space. Titanium isolators decouple the detectors from …

Zoliflodacin Versus Ceftriaxone Plus Azithromycin For Treatment Of Uncomplicated Urogenital Gonorrhoea: An International, Randomised, Controlled, Open-Label, Phase 3, Non-Inferiority Clinical Trial, Alison Luckey, Manica Balasegaram, Lindley A. Barbee, Teresa A. Batteiger, Helen Broadhurst, Stephanie E. Cohen, Sinead Delany-Moretlwe, Henry J.C. De Vries, Jodie A. Dionne, Katherine Gill, Chris Kenyon, Rossaphorn Kittiyaowamarn, Drew Lewis, John P. Mueller, Vimla Naicker, Seamus O'Brien, John P. O'Donnell, Nittaya Phanuphak, Elizabeth Spooner, Subasree Srinivasan, Stephanie N. Taylor, Magnus Unemo, Zinhle Zwane, Edward W. Hook, Zoliflodacin Phase 3 Study Group

School of Medicine Faculty Publications

Background Development of new treatments for gonorrhoea is a global public health priority. We aimed to evaluate the efficacy and safety of zoliflodacin versus ceftriaxone plus azithromycin in patients with uncomplicated urogenital gonorrhoea. Methods In this phase 3, multinational, randomised, controlled, open-label, non-inferiority clinical trial, participants aged 12 years and older with clinical suspicion of uncomplicated urogenital gonorrhoea were eligible for inclusion. The trial was done in 17 outpatient clinics in Belgium, the Netherlands, South Africa, Thailand, and the USA. Participating countries with high disease prevalence were identified for participation in the study. Sites selected for participation were led by …

Fibrinogen-Associated Plasma Metabolites And Implications For Coagulation, Inflammation, And Vascular Diseases, Jayna C Nicholas, Taryn Alkis, Joshua C Bis, Eric Boerwinkle, Jennifer A Brody, Clary B Clish, Paul S De Vries, Yan Gao, Robert E Gerzsten, Xiuqing Guo, Andrew D Johnson, Martin G Larson, Rozenn N Lemaitre, Bruce M Psaty, Vasan Ramachandran, Alexander P Reiner, Stephen S Rich, Benjamin Rodriguez, Jian Rong, Jerome I Rotter, Jeanette Simino, Nicholas L Smith, James Wilson, Jie Yao, Alanna C Morrison, Bing Yu, Laura M Raffield

Faculty, Staff and Student Publications

Background: Fibrinogen is a critical coagulation factor that plays an essential role in thrombosis and is elevated in individuals with chronic inflammation. Here, we used fibrinogen as a representative quantitative measure of pro-coagulant risk and evaluated metabolites associated with fibrinogen levels through non-targeted plasma metabolomic profiling (Broad and Metabolon platforms).

Methods: Our analysis included 10,533 individuals across six U.S. based cohorts representing diverse population groups. The cross-sectional relationship between each of 789 tested metabolites and plasma fibrinogen concentration was assessed with adjustment for relevant covariates such as age, sex, body mass index, and circulating lipoprotein levels.

Results: Meta-analysis of per-cohort …

Biogeochemical Cycling Of Dissolved Zinc And Zinc Isotopes In The Arctic Ocean, Elise Langer, Dylan J. Halbeisen, Ruifeng Zhang, Seth G. John, Tim M. Conway

Making Waves REU

• Dissolved Zinc (dZn) is an essential micronutrient that supports primary productivity in the ocean (Morel & Price, 2003).
• Dissolved zinc isotope ratios (δ⁶⁶Zn) help us understand the sources, sinks, and internal cycling of dZn (Bermin et al. 2006; Conway and John, 2014, Horner et al. 2021).
• The background deep ocean has a largely homogenous δ⁶⁶Zn composition of +0.45‰ (Conway and John, 2014), thus deviations away from +0.45±0.05‰ suggest dZn input, loss, or alteration (Fig. 1).
• We hypothesize that margin sediments and freshwater input deliver isotopically light dZn to the coastal Arctic (Jensen et al. 2019).
• Near the North Pole, We …

Gh Alters Lymphatic Vessels In Female Mice And Stat5 Phosphorylation In Human Lymphatic Endothelial Cells, Christopher Walsh, Emily Scott, Elise Wagner, Jerome Walsh, Shashank Reddy, Arshad Ahmad, Reetobrata Basu, Eva Sevick-Muraca, Rich Brody, Uday Sandbhor, Sebastian Neggers, John J Kopchick

The Brown Foundation: Institute of Molecular Medicine

Disruption of lymphatic function underlies a broad spectrum of inflammatory and metabolic disorders, yet the hormonal pathways that regulate lymphatic biology remain poorly defined. GH, which is implicated in similar disease states, has an unclear role in lymphatic homeostasis. To address this gap, we investigated how chronic alterations in GH signaling alter lymphatic structure and function. Using transgenic mouse lines with increased, decreased, or absent GH action, we quantified the effect of GH on lymphatic pumping rate and lymphangiogenic remodeling during wound healing using near-infrared fluorescent imaging. We also measured markers of lymphatic endothelial cells using Western blot and immunohistochemistry …

Eeg Pressure Injuries, Paula Ebert

Nursing Grand Rounds

EEG Pressure Injuries. Paula Ebert, MS, RN, CNS, ACCNS-AG, CCRN, SCRN

Objectives:

• Understand the clinical impact of pressure injuries related to EEG
• Understand the implemented changes to reduce pressure injuries related to EEG
• Understand the multidisciplinary approach to addressing the problem

Utilizing Machine Learning Techniques For Computer-Aided Covid-19 Screening Based On Clinical Data, Honglun Xu, Andrews T. Anum, Michael Pokojovy, Sreenath Chalil Madathil, Yuxin Wen, Md. Fashiar Rahman, Tzu-Liang Bill Tseng, Scott Moen, Eric Walser

Engineering Faculty Articles and Research

The COVID-19 pandemic has highlighted the importance of rapid clinical decision-making to facilitate the efficient usage of healthcare resources. Over the past decade, machine learning (ML) has caused a tectonic shift in healthcare, empowering data-driven prediction and decision-making. Recent research demonstrates how ML was used to respond to the COVID-19 pandemic. This paper puts forth new computer-aided COVID-19 disease screening techniques using six classes of ML algorithms (including penalized logistic regression, random forest, artificial neural networks, and support vector machines) and evaluates their performance when applied to a real-world clinical dataset containing patients’ demographic information and vital indices (such as …

Omar Folk V. Usa

2026 Decisions

USDC for the Middle District of Pennsylvania

New Hampshire Child Care Scholarship Program Reaches Young Children Statewide, Harshita Sarup, Jess Carson

Carsey Publications

In this brief, authors Harshita Sarup and Jess Carson offer an update on enrollment in the New Hampshire Care Scholarship Program and describe the age and geographic distribution of enrolled children. Using data from the New Hampshire Department of Health and Human Services, the authors confirm that enrollment more than doubled between December 2023—just before program eligibility was expanded in January 2024—and December 2025. More than 5,800 children, two-thirds of whom are under age five, are now served through the program, reaching each county of the state. The authors underscore the importance of continuously tracking program implementation and leveraging local …

Defining Rna Oligonucleotides That Reverse Deleterious Phase Transitions Of Rna-Binding Proteins With Prion-Like Domains., Lin Guo, Jacob Mann, Jocelyn Mauna, Katie Copley, Hejia Wang, Jack Rubien, Cristian Bergmann, Jenny Carey, Jessica Merjane, Marilyn Ngo, Jiazhen Xu, Hana Odeh, Jiabei Lin, Bo Lim Lee, Laura Ganser, Emma Robinson, Kevin Kim, Anastasia Murthy, Tapas Paul, Bede Portz, Amanda Gleixner, Zamia Diaz, Ashleigh Smirnov, George Padilla, Ellen Lavorando, Carolann Espy, Yulei Shang, Eric Huang, Alessandra Chesi, Nicolas Fawzi, Sua Myong, Christopher Donnelly, James Shorter

Department of Biochemistry and Molecular Biology Faculty Papers

RNA-binding proteins (RBPs) with prion-like domains (PrLDs), such as FUS and TDP-43, condense into functional liquids, which can transform into pathological fibrils that underpin fatal neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD). Here, we define short RNAs that prevent FUS fibrillization by promoting liquid phases and distinct short RNAs that prevent and reverse FUS condensation and fibrillization. These activities require interactions with multiple RNA-binding domains of FUS and are encoded by RNA sequence, length, and structure. We define a short RNA that dissolves cytoplasmic FUS aggregates, restores nuclear FUS, and mitigates FUS toxicity in optogenetic models and ALS …

Longitudinal Observation Of Children With Achondroplasia: Findings From A Global Natural History Study (Achieve), Ciara Mcdonnell, Hanne Buciek Hove, Melita Irving, Klane K White, Cesar G Fontecha, Janet M Legare, Wolfgang Högler, Daniel G Hoernschemeyer, Dirk Schnabel, Sheila Unger, Carlos Alberto Bacino, Paul Hofman, Yongguo Yu, Huamei Ma, Chunxiu Gong, Xiaoping Luo, T Andrew Burrow, Geneviève Baujat, Stefano Mora, Melissa Fiscaletti, Carol Zhao, Michael A Makara, Aimee D Shu, Ravi Savarirayan

Faculty, Staff and Students Publications

Introduction: The ACHieve study assessed growth velocity, body proportionality, and clinical events in children with achondroplasia not receiving growth-promoting therapy.

Methods: ACHieve was a global, longitudinal, prospective, observational study. Children ≤8 years old with achondroplasia were enrolled and evaluated every 6 months for anthropometric parameters and clinical events.

Results: ACHieve enrolled 259 children in 15 countries, including 83 from China. Median follow-up was 21 months; median age of diagnosis was approximately 52 weeks in China and 2 weeks elsewhere. Growth parameters were similar regardless of region. Mean annualized growth velocity was 9.3 cm/year for males and 10.4 cm/year for females …

Development Of A New Clinical Prediction Rule For Candidaemia, Diego U Vazquez-Omana, Paula Beltran-Reyes, Jorge E Alonso-Montoya, Nayeli E Avalos-Celis, Edgar D Centeno-Matus, Sandra Rajme-Lopez, Karla M Tamez-Torres, Bernardo A Martinez-Guerra, Carla M Román-Montes, Luis Ostrosky-Zeichner, Alfredo Ponce-De-Leon, María F Gonzalez-Lara

Faculty, Staff and Student Publications

Background: Candidaemia is a leading cause of hospital-acquired bloodstream infections, especially in intensive care unit (ICU) patients, and is associated with high mortality and healthcare costs. Prediction rules aid in the identification of patients at risk of developing candidaemia. This study aimed to develop a prediction rule for candidaemia within our population and evaluate its performance against two established rules: the Ostrosky-2 and the Nebraska Medical Center (NMC).

Methods: We conducted a case-control study at a tertiary care center in Mexico City. Data were collected from candidaemia patients and controls matched by sex, age, admission area, and prior hospitalization at …

Multi-Institutional Normal Tissue Complication Probability (Ntcp) Prediction Model For Mandibular Osteoradionecrosis: Results From The Predmorn Study, Laia Humbert-Vidan, Christian R Hansen, Steven Petit, Carles Muñoz-Montplet, Katrina Hueniken, Abdallah S R Mohamed, Deborah P Saunders, Vinod Patel, Gerda M Verduijn, Wilma D Heemsbergen, Arjen Van Der Schaaf, Max Witjes, Suzanne P M De Vette, Mohammad Moharrami, Abdul A Khan, Jordi Marruecos Querol, Irene Oliveras Cancio, Mike Oliver, Peter Reich, Stacey A Santi, Andrew G Pearce, Stephen Y Lai, Andrew P King, Ali Hosni, Andrew J Hope, Erin E Watson, Johannes A Langendijk, Jørgen Johansen, Amy C Moreno, Clifton D Fuller, Lisanne V Van Dijk, Teresa Guerrero Urbano

Faculty, Staff and Student Publications

Purpose: Mandibular osteoradionecrosis (ORN) is a severe late complication affecting patients with head and neck cancer (HNC) treated with radiation therapy (RT) that significantly impacts patients' quality of life and can require costly interventions. Although radiation dose is a key factor, other clinical and demographic risk factors also influence ORN development. Previous predictive models have primarily been single-institutional, limiting their generalizability. In this first analysis from the PREDMORN Consortium, we have aimed to reproduce existing statistical association and modeling analyses on the largest and most diverse mandibular ORN cohort worldwide to allow comparison with previous studies.

Methods and materials: This …

Comparison Of Surgery And Medicine On The Impact Of Diverticulitis (Cosmid) Trial: A Protocol For A Pragmatic Randomised Study Of Diverticulitis Treatment In The Usa, Mariam N Hantouli, Robert H Schmicker, Janice E Tufte, Fadwa G Ali, Robert D Bennett, Jessica N Cohan, Bryan A Comstock, Thomas Curran, Giana H Davidson, Samuel Eisenstein, Katherine N Fischkoff, Fergal J Fleming, Irena Gribovskaja-Rupp, Mehraneh Dorna Jafari, Larry G Kessler, Mukta K Krane, Sarah O Lawrence, James T Mccormick, Stefanos G Millas, Arden M Morris, Kelsey M Pullar, Caroline E Reinke, Julia T Saraidaridis, Vlad V Simianu, Suzanne P Watkins, Nicole B White, Elizabeth C Wick, Nicole Wieghard, David R Flum, Thomas E Read

Faculty, Staff and Student Publications

Introduction: Each year, millions of people experience recurrent diverticulitis episodes. Elective sigmoid colon resection reduces the risk of recurrence, but The American Society of Colon and Rectal Surgeons recommends individualising surgical decisions based on the impact of the condition on a patient's quality of life (QoL). However, no threshold for QoL impairment has been established to guide decision-making, and evidence comparing elective colectomy with medical management in terms of QoL limitation is limited. To address these gaps and to guide treatment decision-making, we designed the Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) trial.The COSMID trial is …

Disparities In Cardiovascular Disease Burden Among Black And Hispanic Survivors Of Adolescent And Young Adult (Aya) Cancer, Tori Tonn, Maanvi Thawani, Margaret Mazer, Greg Aune, Debra Eshelman-Kent, Karen Albritton, Efstratios Koutroumpakis, Michael E Roth, Michelle A T Hildebrandt

Faculty, Staff and Student Publications

Background: Despite significant improvements in long-term survival outcomes for adolescents and young adults (AYAs) with cancer, common treatment regimens often pose substantial risks to the cardiovascular health of this survivor population. Differences in cardiovascular events by race/ethnicity and genetic ancestry within this at risk population remain unclear.

Methods: In this study, we investigated adverse cardiovascular outcomes in a diverse population of AYA cancer survivors (n = 346) treated at MD Anderson Cancer Center for Hodgkin lymphoma and sarcoma. Analysis was conducted by self-identified race/ethnicity and by genetic ancestry.

Results: Black and Hispanic survivors demonstrated the greatest burden of poor …

Generative Synthesis Of Historical Precedents For Automated Procedural Guidance, Pooja Agrawal, Tanmay Kayande, Akash Dambhare, Deep Raithatha, Mohith P

Defensive Publications Series

Knowledge workers in enterprise environments can face challenges when resolving complex inquiries, as they may need to manually parse and synthesize information from multiple historical precedents. Existing retrieval systems may identify relevant cases but can leave the cognitive burden of synthesis to the user. Systems are described that can automate the synthesis of insights. For example, a system may use a semantic similarity model to retrieve a set of procedurally analogous historical cases from a data repository. A generative synthesis module could then compile data from these retrieved cases into a structured prompt for a large language model. The model …

Remote Procedure Call Performance Service For Performance Testing, Reda Nassif Haddad

Defensive Publications Series

A new remote procedure call (gRPC) performance service is proposed herein, referred to as a gRPC-Perf service, which can enable a network operator to understand gRPC limitations for any gRPC service that the network operator intends to use between any two points in a network. The gRPC-Perf service may also be useful for troubleshooting gRPC performance issues (e.g., whether an issue is a client issue or a network issue based on direction of traffic).

Agentic Framework Integrating Rag For Policy Queries And Autonomous Trend Analysis, Tanmay Kayande, Deep Raithatha, Akash Dambhare, Mohith P, Pooja Agrawal

Defensive Publications Series

Tools that just pull up whole, complicated company policy documents often don't help people find the specific answers they need. This new technology is a system for understanding and analyzing policies that works in two ways.

A "Reactive" Mode acts like a Q&A tool. It uses advanced technology (retrieval-augmented generation) to break down policies into small, searchable pieces. This allows the system to give direct answers with citations and even run simulations to show what happens in different situations based on the rules.

A "Proactive" Mode is an automated agent that constantly checks support data to spot trends and see …

On-Chip Thermal Monitoring And Mitigation For Semiconductor Design-For-Test, Veerabhadra Rao Vasa, Maheedhar Jalasutram, Aditya Kota, Swathi G

Defensive Publications Series

During semiconductor design-for-test operations, the application of high-activity test patterns can generate localized heat as functional-mode thermal management systems may be inactive. A hardware-based architecture can integrate localized monitoring modules near potential thermal hotspots. A module can operate synchronously with test patterns to capture peak temperature values and their corresponding test pattern counts. The system may also include a mitigation circuit that compares real-time temperature against a configurable threshold and can throttle system clocks if the threshold is exceeded to reduce heat generation. This approach can provide thermal observability and control in a test environment, enabling the creation of thermal …

Ratcheting Hinge With User-Actuated Lock For Temple Arm Declination, Yaaseen Mahomed, Jon Hurwitz

Defensive Publications Series

Wearable electronic devices (e.g., smart glasses, augmented reality headsets, etc.) rigid frames may not accommodate diverse head geometries, as a fixed temple arm declination angle can lead to discomfort, instability, and optical misalignment. This disclosure describes a user-actuated hinge assembly for adjusting the declination angle of a temple arm. The assembly may comprise a pair of intermeshing geared components, one coupled to the device's main frame and the other to the temple arm. A user-operable, spring-biased clamping element can engage one of the geared components to lock the angular position. Actuating a control can disengage the clamp, permitting rotational adjustment …

Automated Database Selection Via Empirical Validation And Cost-Adjusted Scoring, Nazar Ahamed, Navakanth Talluri

Defensive Publications Series

Selecting a database service can be challenging when decisions rely on static information or generalized benchmarks, which may not align with an application's specific runtime performance needs, potentially leading to implementation risks. A system can provide automated, performance-validated database recommendations. The system can translate a user's non-functional requirements into a profile used to programmatically provision temporary test environments for candidate databases. A workload generator can then simulate a user's specific application load within these environments, which may allow the system to harvest real-time performance and cost metrics. The collected empirical data can be processed by a scoring algorithm to calculate …

End Point–Based Threshold For The Ambulatory Arterial Stiffness Index, Yi-Bang Cheng, De-Wei An, Dong-Yan Zhang, Yu-Ling Yu, Jesus D. Melgarejo, José Boggia, Dries S. Martens, Tine W. Hansen, Kei Asayama, Gladys E. Maestre

School of Medicine Publications

Background: The ambulatory arterial stiffness index (AASI) is increasingly used in clinical research and practice. This individual-participant meta-analysis aims to consolidate the prognostic accuracy of AASI in the general population and to derive an end point-based AASI risk threshold.

Methods: In 12 558 individuals enrolled in 14 population studies (48.8% women; mean age, 59.3 years), AASI was derived by regressing 24-hour diastolic on systolic blood pressure (mm Hg/mm Hg). Using Cox regression, the risk-carrying AASI threshold was established by examining stepwise increasing AASI levels and by determining the AASI level, yielding a 10-year risk similar to an office systolic pressure …

Optimal Timing Of Cranioplasty Post-Decompressive Craniectomy In Traumatic Brain Injury: A Systematic Review, Meta-Analysis, And Overview Of Ongoing Trials, Ashviniy Thamilmaran, Shaan Patel, Shiva A. Nischal, Honey Panchal, Kush Kale, Pious D. Patel, Jack Jallo, James S. Harrop

Department of Neurosurgery Faculty Papers

BACKGROUND: The optimal timing of cranioplasty (CP) following decompressive craniectomy (DC) for the management of traumatic brain injury (TBI) remains debated. Prior studies comparing early CP (EC) and late CP (LC) report conflicting outcomes, compounded by inconsistent timing thresholds and limited attention to effect modifiers such as implant material.

OBJECTIVE: To perform a systematic review and meta-analysis comparing outcomes of EC (≤ 90 days) versus LC (> 90 days) after DC for TBI, with particular evaluation of ultra-EC (<  35 days) and implant material.

METHODS: MEDLINE, Embase, and CENTRAL were electronically searched from inception to April 2025, supplemented by manual screening of references and grey …

Uplink Latency Reduction In Non-Terrestrial Networks Via Predictive Scheduling Request, Edison Chen

Defensive Publications Series

Standard reactive scheduling request (SR) procedures in high-latency Non-Terrestrial Networks (NTNs) cause uplink delays, as a user equipment (UE) must wait a full round-trip time (RTT) for an uplink grant after data becomes available. This is compounded for large data transfers, which may require two RTTs for SR and Buffer Status Report (BSR) cycles. This disclosure describes a proactive scheduling mechanism where the UE sends an SR in advance of data arriving in its buffer. Based on predicted traffic, informed by application-layer signaling or an on-device machine learning model, the SR is timed to ensure the uplink grant arrives just-in-time …