Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Social and Behavioral Sciences (657511)
- Arts and Humanities (572294)
- Law (543147)
- Education (382097)
- Medicine and Health Sciences (324666)
-
- Physical Sciences and Mathematics (292337)
- Life Sciences (256067)
- Engineering (195829)
- History (181336)
- Business (148815)
- Higher Education (142709)
- Anthropology (115940)
- Religion (109808)
- Archaeological Anthropology (96468)
- Communication (89122)
- Sociology (86198)
- Library and Information Science (80016)
- United States History (77482)
- Medical Specialties (76793)
- Psychology (73537)
- Computer Sciences (62956)
- Public Affairs, Public Policy and Public Administration (62178)
- Earth Sciences (59314)
- Creative Writing (57898)
- Public Health (55570)
- Environmental Sciences (52321)
- English Language and Literature (47450)
- Economics (46662)
- Educational Administration and Supervision (46470)
- Music (45875)
- Institution
-
- University of South Florida (162984)
- University of New Mexico (139108)
- University of Nebraska - Lincoln (114003)
- Kenyon College (112912)
- University of Montana (98218)
-
- University of Mississippi (94101)
- University of New Hampshire (79651)
- Brigham Young University (72144)
- Georgia Southern University (61490)
- Eastern Illinois University (57888)
- Utah State University (57314)
- Mississippi State University (54507)
- Western Michigan University (52950)
- University of Kentucky (52306)
- Murray State University (50459)
- Purdue University (50068)
- University of Colorado Law School (47444)
- Louisiana State University (45135)
- Brigham Young University Law School (43600)
- University of Dayton (43225)
- Western Kentucky University (43085)
- Villanova University Charles Widger School of Law (42711)
- California Polytechnic State University, San Luis Obispo (42483)
- University of Central Florida (41626)
- Chulalongkorn University (37308)
- San Jose State University (36962)
- University of Alabama at Birmingham (35953)
- University of Northern Iowa (35946)
- Yale University (33787)
- Missouri University of Science and Technology (33636)
- Keyword
-
- Newspaper (47274)
- Latin America (31531)
- Press release; media release; press statement; news media information (30839)
- Spanish (30833)
- History (30077)
-
- University of New Mexico (29735)
- UNM (29638)
- LADB (29608)
- LAII (29608)
- Latin American and Iberian Institute (29608)
- Humans (29360)
- Education (28960)
- United States (21343)
- Student newspaper (19956)
- Newsletter (19706)
- EIU (19627)
- Georgia Southern University (18903)
- Newspapers (18264)
- Deaf culture (17102)
- Hearing impaired (17091)
- Pastoral care of people with disabilities (17060)
- Church work with the deaf -- Catholic Church (17052)
- Deaf -- Periodicals (17043)
- Athletics (16848)
- Marriage (16178)
- Poetry (15531)
- Students (15110)
- Higher education (14576)
- COVID-19 (14393)
- Female (14193)
- Publication Year
-
- 2026 (101368)
- 2025 (156112)
- 2024 (192479)
- 2023 (162647)
- 2022 (167689)
-
- 2021 (195838)
- 2020 (169181)
- 2019 (165261)
- 2018 (169410)
- 2017 (160776)
- 2016 (159498)
- 2015 (146205)
- 2014 (135644)
- 2013 (129979)
- 2012 (124605)
- 2011 (108178)
- 2010 (103548)
- 2009 (95636)
- 2008 (92722)
- 2007 (79179)
- 2006 (74488)
- 2005 (70091)
- 2004 (71227)
- 2003 (58603)
- 2002 (64451)
- 2001 (55051)
- 2000 (58447)
- 1996 (62276)
- 1992 (52971)
- 1990 (53641)
- Publication
-
- Four Valleys Archive (90475)
- Theses and Dissertations (74001)
- Faculty Publications (45619)
- Electronic Theses and Dissertations (35895)
- University of Montana News Releases, 1928, 1956-present (30910)
-
- Faculty Scholarship (25288)
- Dissertations (23668)
- The Auk (22791)
- Documents (21830)
- Theses (21677)
- Articles (19990)
- Browse All News (19555)
- Walden Dissertations and Doctoral Studies (19539)
- Masters Theses (18625)
- Master's Theses (18420)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (15281)
- Session Laws 1951-2000 (15051)
- NotiSur (13785)
- Faculty, Staff and Student Publications (13688)
- Hillsborough County Marriage Records (13681)
- University of Mississippi News (13497)
- Obituaries (13320)
- The Murray Ledger & Times (13003)
- Sheet Music Collection (12976)
- Michigan Law Review (12806)
- University of Montana Course Syllabi (12469)
- Honors Theses (12162)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (11863)
- Condor (11821)
- Defensive Publications Series (11692)
- Publication Type
Articles 86251 - 86280 of 5149642
Full-Text Articles in Entire DC Network
A Recurrent Neural Network For Forecasting Dead Fuel Moisture Content With Inputs From Numerical Weather Models, Jonathon Hirschi, Jan Mandel, Kyle Hilburn, Angel Farguell
A Recurrent Neural Network For Forecasting Dead Fuel Moisture Content With Inputs From Numerical Weather Models, Jonathon Hirschi, Jan Mandel, Kyle Hilburn, Angel Farguell
Faculty Research, Scholarly, and Creative Activity
This paper proposes a recurrent neural network (RNN) model of dead 10 h fuel moisture content (FMC) for real-time forecasting. Weather inputs to the RNN are forecasts from the High-Resolution Rapid Refresh (HRRR), a numerical weather model. Geographic predictors include longitude, latitude, and elevation. Forecast accuracy is estimated in a study that utilizes a spatiotemporal cross-validation scheme. The RNN is trained on HRRR forecasts and observed FMC from weather station sensors within the Rocky Mountain region in 2023, then used to forecast FMC at new locations for all of 2024. The model is evaluated using a 48 h forecast window. …
Multisystem Challenges In Reproductive Medicine: A Case Report Of Bicornuate Uterus, Fibroadenoma, And Postpartum Thyroiditis, Fatima Faisal, Aiman Javed, Faisal Muzaffar, Tirath Patel, Ahmed Ibrahim, Fathimathul Henna, Hafiza Tooba Siddiqui, Bhumi Patel, Nana Sardarova, Nikhilesh Anand
Multisystem Challenges In Reproductive Medicine: A Case Report Of Bicornuate Uterus, Fibroadenoma, And Postpartum Thyroiditis, Fatima Faisal, Aiman Javed, Faisal Muzaffar, Tirath Patel, Ahmed Ibrahim, Fathimathul Henna, Hafiza Tooba Siddiqui, Bhumi Patel, Nana Sardarova, Nikhilesh Anand
School of Medicine Publications
Rationale: A bicornuate uterus is an uncommon mullerian duct malformation strongly associated with recurrent early pregnancy loss and adverse obstetric outcomes. When combined with endocrine disturbances such as hyperprolactinemia and postpartum thyroid dysfunction, fertility becomes even more challenging. This case highlights how coordinated reproductive-endocrine management can overcome multiple intersecting barriers to conception and successful pregnancy.
Patient concerns: A 24-year-old woman presented with a history of 3 first-trimester miscarriages, difficulty conceiving, and prior breast fibroadenoma excision. Following the birth of her first child, she later developed symptoms of palpitations, weight loss, and anxiety suggestive of thyroid dysfunction.
Diagnoses: Pelvic ultrasonography identified …
Career Plans Among Graduating Us Emergency Medicine Residents, Dave W. Lu, Bo Gu, D. Mark Courtney, Bryan G. Kane, Michelle D. Lall, Michael Gottlieb, Yvette Calderon, Christopher Bennett
Career Plans Among Graduating Us Emergency Medicine Residents, Dave W. Lu, Bo Gu, D. Mark Courtney, Bryan G. Kane, Michelle D. Lall, Michael Gottlieb, Yvette Calderon, Christopher Bennett
Department of Emergency Medicine Faculty Papers
IMPORTANCE: The emergency medicine (EM) workforce is undergoing complex change, including a potential projected physician surplus, the volatile and evolving interests of medical students, and the continued high rates of burnout. Understanding the career intentions of graduating residents is critical to inform workforce planning.
OBJECTIVE: To examine the career plans, anticipated career durations, and key factors associated with the career decisions of graduating US EM residents.
DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional survey study, which sampled graduating residents from all Accreditation Council for Graduate Medical Education-accredited categorical EM programs, was conducted after the 2023 American Board of Emergency Medicine In-Training …
Career Plans Among Graduating Us Emergency Medicine Residents, Dave W. Lu, Bo Gu, D. Mark Courtney, Bryan G. Kane, Michelle D. Lall, Michael Gottlieb, Yvette Calderon, Christopher Bennett
Career Plans Among Graduating Us Emergency Medicine Residents, Dave W. Lu, Bo Gu, D. Mark Courtney, Bryan G. Kane, Michelle D. Lall, Michael Gottlieb, Yvette Calderon, Christopher Bennett
Department of Emergency Medicine Faculty Papers
IMPORTANCE: The emergency medicine (EM) workforce is undergoing complex change, including a potential projected physician surplus, the volatile and evolving interests of medical students, and the continued high rates of burnout. Understanding the career intentions of graduating residents is critical to inform workforce planning.
OBJECTIVE: To examine the career plans, anticipated career durations, and key factors associated with the career decisions of graduating US EM residents.
DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional survey study, which sampled graduating residents from all Accreditation Council for Graduate Medical Education-accredited categorical EM programs, was conducted after the 2023 American Board of Emergency Medicine In-Training …
Gods' Man, Lynd Ward
Gods' Man, Lynd Ward
Zea E-Books Collection
Lynd Ward (1905–1985) was born in Chicago and studied at Columbia Teachers College in New York City and at the National Academy of Graphic Arts and Bookmaking in Leipzig, Germany. He began working as a book illustrator in 1927, and in 1929 published this first “wordless novel,” Gods’ Man. He eventually published five more such works, as well as illustrations for more than 100 other books, plus drawings, lithographs, watercolors, and children’s stories.
Gods’ Man is credited as the first American wordless novel. It tells a story about a struggling young artist who makes a pact with a mysterious …
Effects Of Ai Transparency On Perceived Fairness In Ai-Driven Selection Tools: The Mediating Roles Of Ai Literacy And Attitudes Towards Ai, Tony Mellek
Industrial-Organizational Psychology Dissertations
Artificial intelligence is becoming an increasingly prominent feature of modern hiring, creating opportunities to enhance efficiency and consistency in selection. This study examined how AI transparency, AI literacy, and attitudes toward AI shape applicants’ perceptions of fairness when engaging with AI-scored pre-hire assessments. A sample of 290 U.S. adults were randomly assigned to either a high- or low-transparency hiring scenario and then completed measures of AI literacy, attitudes toward AI, and procedural fairness. Results indicated that both AI literacy and attitudes toward AI were strong and significant predictors of perceived procedural fairness, suggesting that applicants who feel knowledgeable about AI …
Cognitive And Economic Development, John Luke Gallup
Cognitive And Economic Development, John Luke Gallup
Economics Faculty Publications and Presentations
A burgeoning literature has found that early childhood health conditions of individuals have large causal effects on their cognitive development, education and earnings. How much does early cognitive development contribute to the national economy? Although researchers have long studied the role of worker health for economic growth, they have not assessed the role of early cognitive development.
Cognitive ability is the foundation of human capital, affecting both educational attainment and economic growth. The risk factors for poor cognitive development are very high in many countries. Each risk factor also causes child mortality, making child survival a viable proxy for good …
Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Revised Draft Final 2022 Unreclaimed Sites Sampling: Ur-06 Site Evaluation Summary Report (Dated December 10, 2025), Molly Roby
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
A Visualization-Supported, Hierarchical, Action-Learning Model For Driving Behavior In A V2x Environment, Xuantong Wang, Jing Li, Jecca Bowen
A Visualization-Supported, Hierarchical, Action-Learning Model For Driving Behavior In A V2x Environment, Xuantong Wang, Jing Li, Jecca Bowen
Geography and the Environment: Faculty Scholarship
Understanding human driving decisions is crucial for intelligent transportation research. Most existing studies focus on individual vehicles in limited contexts, which restricts broader applicability of results. Leveraging Vehicle-to-Everything (V2X) infrastructure, this study introduces a machine learning framework to model driving actions and detect outliers across diverse environments. This approach features a semantically enabled clustering method that groups similar driving behaviors based on speed and actions. It also adds a time-series learning model to identify typical driving behaviors across various contexts, thereby enabling detection of abnormal driving actions. A suite of visual tools has been developed to help interpret driving patterns, …
Reported Safety Practices Of Publicly Advertised Psychedelic Retreats, Amy L Mcguire, Logan Neitzke-Spruill, Jill O Robinson, Caroline S Beit, Nikita Singh, David S Mathai, Lynnette A Averill
Reported Safety Practices Of Publicly Advertised Psychedelic Retreats, Amy L Mcguire, Logan Neitzke-Spruill, Jill O Robinson, Caroline S Beit, Nikita Singh, David S Mathai, Lynnette A Averill
Center for Medical Ethics and Health Policy Staff Publications
Importance: The availability of psychedelic retreats has grown to meet the demand for access to these substances. Despite centuries of use among Indigenous communities, psychedelics can pose serious risks for some users.
Objective: To determine safety precautions that retreat organizations that offer psychedelic substances currently use.
Design, setting, and participants: This qualitative study included structured interviews conducted by phone or email with representatives from 49 organizations publicly advertising psychedelic retreat offerings from July to October 2023. Organizations were eligible if they marketed their services in English, offered at least 1 psychedelic substance, and made contact information available online. Organizations were …
Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Revised Draft Final 2022 Unreclaimed Sites Sampling: Ur-12 Site Evaluation Summary Report (Dated December 9, 2025), Molly Roby
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Continuous Learning And Customer Value Creation In The Healthcare: Mediating Effects Of Innovations Adoption Value Recognition, Binto M. Binto, Omari Khalifa Mbura
Continuous Learning And Customer Value Creation In The Healthcare: Mediating Effects Of Innovations Adoption Value Recognition, Binto M. Binto, Omari Khalifa Mbura
Business Management Review
This research investigates the influence of continuous learning on the effectiveness of customer value creation in the Tanzania’s healthcare system, with a specific focus on the mediating effects of innovation adoption value recognition. Using a cross-sectional design, data were collected from 360 healthcare professionals across three zonal referral hospitals in Tanzania. Data analysis employed a structural equation modelling using SMART-Partial Least Squares software version 4.0. The findings indicate that continuous learning enhances healthcare customer value creation both directly and indirectly. Also, innovation adoption value recognition serves as a mediating variable of the direct causal relationship, offering partial mediation effects between …
Katherine Birl V. Ski Shawnee Inc
Katherine Birl V. Ski Shawnee Inc
2026 Decisions
USDC for the Middle District of Pennsylvania
Melatonin Use In Young Children: A Systematic Review, Chelsea L. Kracht, Grace Bolamperti, Rob Breeden, Madeline Crocker, Danielle N. Christifano, Robert C. Gibler, Grace Gyllenborg, Peter Johnson, Jacob Lovell, Lauren Mathews, Obianuju Onuoha, Natesh Samaroo, Anna S. Trofimoff, Perry Weidling, Anna Wallisch
Melatonin Use In Young Children: A Systematic Review, Chelsea L. Kracht, Grace Bolamperti, Rob Breeden, Madeline Crocker, Danielle N. Christifano, Robert C. Gibler, Grace Gyllenborg, Peter Johnson, Jacob Lovell, Lauren Mathews, Obianuju Onuoha, Natesh Samaroo, Anna S. Trofimoff, Perry Weidling, Anna Wallisch
Student Publications
Importance: Melatonin is the leading cause of unsupervised medication exposure and overdose in emergency departments for young children (aged 0-6 years). Existing literature has documented the benefits of melatonin in older children (aged 7-18 years) with neurologic conditions but has yet to examine young children.
Objective: To examine the long-term outcomes (safety and effectiveness) associated with melatonin use in young children.
Evidence review: Nine databases, including Ovid MEDLINE, Embase, and Web of Science; 2 clinical trial registries; existing subject matter systematic reviews; and forward and backward citation of included articles were reviewed from inception to February 26, 2025, to identify …
Cost-Effectiveness Of Home-Based Self-Sampling Vs Clinician Sampling For Anal Precancer Screening, Haluk Damgacioglu, Timothy L Mcauliffe, Timothy J Ridolfi, Elizabeth Chiao, Maria E Fernandez, Vanessa Schick, Jennifer S Smith, Bridgett Brzezinski, Jenna Nitkowski, Ashish A Deshmukh, Alan G Nyitray
Cost-Effectiveness Of Home-Based Self-Sampling Vs Clinician Sampling For Anal Precancer Screening, Haluk Damgacioglu, Timothy L Mcauliffe, Timothy J Ridolfi, Elizabeth Chiao, Maria E Fernandez, Vanessa Schick, Jennifer S Smith, Bridgett Brzezinski, Jenna Nitkowski, Ashish A Deshmukh, Alan G Nyitray
Faculty, Staff and Student Publications
Importance: Anal cancer screening is recommended for high-risk populations, particularly sexual and gender minority (SGM) individuals. However, the cost-effectiveness of home-based self-sampling in increasing anal cancer screening uptake has not yet been evaluated in the US.
Objective: To evaluate the cost-effectiveness of home-based anal self-sampling compared with clinic-based screening among SGM individuals.
Design, setting, and participants: This economic evaluation used data from a 2-group randomized clinical trial conducted in Milwaukee, Wisconsin, from January 2020 to August 2022, enrolling SGM individuals aged 25 years or older. Participants were randomized to home-based self-sampling or clinic-based screening. Costs for home-based screening were obtained …
Making Waves Through Expedition, Jenna Malloy, Natalia López-Figueroa, Ana Arellano
Making Waves Through Expedition, Jenna Malloy, Natalia López-Figueroa, Ana Arellano
Making Waves REU
No abstract provided.
Toward A British Guitar Canon: Ernest Shand’S Collected Works, Declan Hickey
Toward A British Guitar Canon: Ernest Shand’S Collected Works, Declan Hickey
Soundboard Scholar
A review of Guitar Music from Late Victorian England: Collected Works, by Ernest Shand, edited by Stanley Yates (Classical Guitar Study Editions, 2022), publisher's website.
770 Lex Holdings Llc V. Reyes
All Decisions
In this nonpayment proceeding, the court granted the tenant's post-eviction Order to Show Cause, restoring the tenant to possession forthwith under RPAPL § 749(3). The re-execution of the warrant of eviction was stayed to allow the tenant to obtain payment for all outstanding rent arrears, along with the landlord's legal and marshal fees. The court noted that ordering post-eviction restoration before full payment is rare. Additionally, the court sua sponte joined the New York City Human Resources Administration (HRA) to the proceeding, pursuant to NYC Civil Court Act § 110(d), to facilitate payment assistance.
Persistent Hypercalcemia: Diagnostic Complexity With Multiglandular Hyperparathyroidism, Renal Cell Carcinoma, And Hereditary Tumor Features, Taylor Yuska, Mckenzie Clark, Yarden Goldman Gollan
Persistent Hypercalcemia: Diagnostic Complexity With Multiglandular Hyperparathyroidism, Renal Cell Carcinoma, And Hereditary Tumor Features, Taylor Yuska, Mckenzie Clark, Yarden Goldman Gollan
Student Publications
Persistent hypercalcemia after parathyroidectomy is a diagnostic challenge that requires careful evaluation beyond the parathyroid glands. We describe the case of a 76-year-old man with chronic kidney disease, resistant hypertension, and vestibular schwannoma who presented with weakness, constipation, and new, dark, raised lesions across his back. He reported undergoing parathyroidectomy one year earlier for presumed primary hyperparathyroidism, after which his hypercalcemia persisted. On admission, serum calcium was 13.1 mg/dL (reference = 8.5-10.5 mg/dL), and examination revealed numerous seborrheic keratoses across his posterior thoracolumbar region, consistent with the Leser-Trélat sign. A Tc-99m sestamibi scan localized a left inferior parathyroid adenoma. MRI …
Failed Retrieval Of An Inferior Vena Cava Filter, Robert B. Murrell, Mitchell Fisher, Christopher Stewart, George Ladas, Samuel Groot, Austin Wagner, Suporn Sukpraprut-Braaten
Failed Retrieval Of An Inferior Vena Cava Filter, Robert B. Murrell, Mitchell Fisher, Christopher Stewart, George Ladas, Samuel Groot, Austin Wagner, Suporn Sukpraprut-Braaten
Student Publications
Inferior vena cava (IVC) filters are devices used to lower the risk of critical pulmonary embolisms in patients with current deep vein thrombosis (DVT) or a high risk of developing such. These devices are used especially when there are contraindications to anticoagulants or when conservative therapy has failed. Typically, IVC filters are temporary and can be retrieved upon improvement in the patient's clotting status.
This case presents a 75-year-old female whose IVC filter retrieval failed. Once cleared by both cardiology and orthopedics, the decision was made to retrieve the IVC filter. First attempts at retrieval proved unsuccessful as the IVC …
Medicaid Expansion And Breast Cancer Care And Outcomes-What Lies Ahead?, Meghan H. Maceyko, Oluwadamilola M. Fayanju
Medicaid Expansion And Breast Cancer Care And Outcomes-What Lies Ahead?, Meghan H. Maceyko, Oluwadamilola M. Fayanju
Department of Surgery Faculty Papers
No abstract provided.
Etoposide-Associated Severe Rhabdomyolysis In A Patient With Diffuse Large B-Cell Lymphoma: A Case Report And Review Of The Literature, Ibrahim Al Nabhani, Ruquiya Al Dhuhli, Farah Al Kindy, Mahmood Al Abri, Khalil Al Farsi, Almundher Al Oraimi
Etoposide-Associated Severe Rhabdomyolysis In A Patient With Diffuse Large B-Cell Lymphoma: A Case Report And Review Of The Literature, Ibrahim Al Nabhani, Ruquiya Al Dhuhli, Farah Al Kindy, Mahmood Al Abri, Khalil Al Farsi, Almundher Al Oraimi
Sultan Qaboos University Medical Journal
Rhabdomyolysis is a clinical syndrome characterised by skeletal muscle necrosis with subsequent release of intracellular constituents into the circulation. Although multifactorial in aetiology, chemotherapeutic agents, including etoposide, are rarely implicated. We report a 62-year-old male who presented to a tertiary care hospital in Muscat, Oman, in 2023 with severe rhabdomyolysis and advanced-stage diffuse large B-cell lymphoma following the first cycle of R-CEOP chemotherapy. Extensive evaluation excluded infectious, inflammatory and structural neuromuscular aetiologies. Work-up for metabolic myopathy suggested, but did not confirm, multiple acyl-CoA dehydrogenase deficiency. The patient’s clinical course was complicated by acute kidney injury necessitating dialysis, followed by gradual …
Circadian-Shaped Immune Variability Predicts Infection Outcome, Jonathan Lalsiamthara, Mariko Locke, Alejandro Aballay
Circadian-Shaped Immune Variability Predicts Infection Outcome, Jonathan Lalsiamthara, Mariko Locke, Alejandro Aballay
Faculty, Staff and Student Publications
Disease risk and severity are influenced by genetics, epigenetics, and environmental factors. However, immune responses vary even among genetically similar or related individuals, shaped by inherited and noninherited factors. Using Caenorhabditis elegans, we found that pathogen susceptibility can be predicted by preinfection biomarkers. Individuals with high-basal expression of irg-5, an infection response gene regulated by the p38 mitogen-activated protein kinase-1 (PMK-1) pathway, were more susceptible to Pseudomonas aeruginosa infection. A genome-wide screen identified the myeloid ecotropic viral integration site-1 (MEIS) homeobox protein UNC-62 as a regulator of irg-5 expression, acting through PMK-1 and GATA binding erythroid-like transcription factor …
Peroxisomal Integrity In Demyelination-Associated Microglia Enables Cellular Debris Clearance And Myelin Renewal In Mice, Joseph A Barnes-Vélez, Xiaohong Zhang, Yaren L Peña Señeriz, Kiersten A Scott, Yinglu Guan, Jian Hu
Peroxisomal Integrity In Demyelination-Associated Microglia Enables Cellular Debris Clearance And Myelin Renewal In Mice, Joseph A Barnes-Vélez, Xiaohong Zhang, Yaren L Peña Señeriz, Kiersten A Scott, Yinglu Guan, Jian Hu
Faculty, Staff and Student Publications
Demyelination associated microglia (DMAM) orchestrate the regenerative response to demyelination by clearing myelin debris and promoting oligodendrocyte maturation. Peroxisomal metabolism has emerged as a candidate regulator of DMAMs, though the cell-intrinsic contribution in microglia remains undefined. Here we elucidate the role of peroxisome integrity in DMAMs, using cuprizone-mediated demyelination coupled with conditional KO of peroxisome biogenesis factor 5 (PEX5) in microglia. Absent demyelination, PEX5 conditional KO (PEX5cKO) had minimal impact on homeostatic microglia. However, during cuprizone-induced demyelination, the emergence of DMAMs unmasked a critical requirement for peroxisome integrity. At peak demyelination, PEX5cKO DMAMs exhibited increased lipid droplet burden and reduced …
Racial, Ethnic, And Socioeconomic Survival Disparities In Early-Onset Metastatic Colorectal Cancer, Jennifer S Wang, Benny Johnson, Caitlin C Murphy
Racial, Ethnic, And Socioeconomic Survival Disparities In Early-Onset Metastatic Colorectal Cancer, Jennifer S Wang, Benny Johnson, Caitlin C Murphy
Faculty, Staff and Student Publications
Importance: Rates of metastatic colorectal cancer (mCRC) are rising among young adults. Disparities by race and ethnicity and neighborhood-level socioeconomic status (SES) among this population are understudied.
Objective: To examine the association of race and ethnicity and neighborhood-level SES with mortality among a community-based sample of young adults with mCRC.
Design, setting, and participants: This cohort study used a large electronic health record-derived database of young adults with cancer treated at 280 community-based US clinics between 2013 and 2021. Eligible patients were young adults aged 18 to 49 years diagnosed with de novo or recurrent mCRC. Patients were followed up …
Cholesterol Efflux Protein, Abca1, Supports Anticancer Functions Of Myeloid Immune Cells, Shruti V Bendre, Yu Wang, Basel Hajyousif, Rajendra K C, Shounak G Bhogale, Dhanya Pradeep, Natalia Krawczynska, Claire P Schane, Erin Weisser, Avni Singh, Simon Han, Hannah Kim, Lara Kockaya, Anasuya Das Gupta, Adam T Nelczyk, Hashni Epa Vidana Gamage, Yifan Fei, Desirée Rodríguez-Casiano, Xingyu Guo, Haoyun Li, Ryan J Deaton, Fei Mo, Maria Sverdlov, Peter H Gann, Saurabh Sinha, Sahil Sahni, Kun Wang, Kevin Van Bortle, Emad Tajkorshid, Wendy A Woodward, Wonhwa Cho, Erik R Nelson
Cholesterol Efflux Protein, Abca1, Supports Anticancer Functions Of Myeloid Immune Cells, Shruti V Bendre, Yu Wang, Basel Hajyousif, Rajendra K C, Shounak G Bhogale, Dhanya Pradeep, Natalia Krawczynska, Claire P Schane, Erin Weisser, Avni Singh, Simon Han, Hannah Kim, Lara Kockaya, Anasuya Das Gupta, Adam T Nelczyk, Hashni Epa Vidana Gamage, Yifan Fei, Desirée Rodríguez-Casiano, Xingyu Guo, Haoyun Li, Ryan J Deaton, Fei Mo, Maria Sverdlov, Peter H Gann, Saurabh Sinha, Sahil Sahni, Kun Wang, Kevin Van Bortle, Emad Tajkorshid, Wendy A Woodward, Wonhwa Cho, Erik R Nelson
Faculty, Staff and Student Publications
Breast and other solid tumors respond poorly to immune therapy. Myeloid cells (MCs) such as macrophages contribute to resistance. Established clinical evidence links cholesterol to cancer outcomes, with MC function being regulated by cholesterol metabolism. We screened MC-expressed regulators of cholesterol homeostasis linked to survival and identified the cholesterol efflux protein ABCA1. ABCA1 activity increases anticancer functions of macrophages: enhancing tumor infiltration, decreasing angiogenic potential, reducing efferocytosis, and improving support of CD8+ T cell activity. Mechanistically, different AKT isoforms are involved, through both PI3K-dependent and PI3K-independent mechanisms. Highlighting the clinical relevance of our findings are correlations between ABCA1 in macrophages …
Nf2 Loss Malignantly Transforms Human Pancreatic Acinar Cells And Enhances Cell Fitness Under Environmental Stress, Yi Xu, Michael H Nipper, Angel A Dominguez, Chenhui He, Francis E Sharkey, Sajid Khan, Han Xu, Daohong Zhou, Lei Zheng, Yu Luan, Jun Liu, Pei Wang
Nf2 Loss Malignantly Transforms Human Pancreatic Acinar Cells And Enhances Cell Fitness Under Environmental Stress, Yi Xu, Michael H Nipper, Angel A Dominguez, Chenhui He, Francis E Sharkey, Sajid Khan, Han Xu, Daohong Zhou, Lei Zheng, Yu Luan, Jun Liu, Pei Wang
Faculty, Staff and Student Publications
Pancreatic ductal adenocarcinoma (PDAC) occurs as a complex, multifaceted event driven by the interplay of tumor-permissive genetic mutations, the nature of the cellular origin, and microenvironmental stress. In this study, using primary human pancreatic acinar 3D organoids, we performed a CRISPR-KO screen targeting 199 potential tumor suppressors curated from clinical PDAC samples. Our data revealed significant enrichment of a list of candidate genes, with neurofibromatosis type 2 associated gene (NF2) emerging as the top target. Functional validation confirmed that loss of NF2 promoted the transition of PDAC to an invasive state, potentially through extracellular matrix modulation. NF2 inactivation …
Person-Centered Care In Adult Auditory Rehabilitation: A Scoping Review, Marien Alet Graham, Nannette Nicholson, Rachel Glade, Sonja Delport, Faheema Mahomed-Asmail
Person-Centered Care In Adult Auditory Rehabilitation: A Scoping Review, Marien Alet Graham, Nannette Nicholson, Rachel Glade, Sonja Delport, Faheema Mahomed-Asmail
Communication Disorders and Occupational Therapy Faculty Publications and Presentations
Objective To scrutinise the efficacy of person-centered care (PCC) in enhancing outcomes for adults navigating hearing loss through a comprehensive examination of literature on PCC in auditory rehabilitation (AR). Design A scoping review was conducted following Joanna Briggs Institute guidelines and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews (PRISMA-ScR) reporting standards. A context framework guided the research question. Study Sample Structured searches across multiple databases identified 36 records which were categorised by research design, mapped by the first author's country, and depicted by number of publications per year. Six identified elements of PCC were anaylzed …
Prospective Audit And Feedback By Antibiotic Stewardship Teams To Reduce Antibiotic Overuse At Hospital Discharge: A Stepped-Wedge Cluster-Randomized Clinical Trial, Daniel J Livorsi, Michael Joshua Hendrix, Erin Rachmiel, Jahnavi Bongu, Alice Bewley, Kevin Hsueh, Et Al.
Prospective Audit And Feedback By Antibiotic Stewardship Teams To Reduce Antibiotic Overuse At Hospital Discharge: A Stepped-Wedge Cluster-Randomized Clinical Trial, Daniel J Livorsi, Michael Joshua Hendrix, Erin Rachmiel, Jahnavi Bongu, Alice Bewley, Kevin Hsueh, Et Al.
2020-Current year OA Pubs
IMPORTANCE: Antibiotics prescribed at hospital discharge are frequently unnecessary or suboptimal. Strategies to improve prescribing are not well defined.
OBJECTIVE: To evaluate whether a discharge-focused prospective audit and feedback process decreases antibiotic overuse at hospital discharge.
DESIGN, SETTING, AND PARTICIPANTS: This stepped-wedge cluster-randomized clinical trial was conducted across participating units at 10 hospitals with antibiotic stewardship (AS) teams and supporting staff from December 5, 2022, to November 17, 2023. After a 24-week baseline period, 1 hospital crossed into the intervention arm every 2 weeks.
INTERVENTION: The intervention consisted of disseminating institutional guidelines for oral antibiotic step-down to frontline prescribers and …