Digital Commons Network^™

Dose-Dependent Ifn Programs In Myeloid Cells After Mrna And Adenovirus Covid-19 Vaccination., Giray N Eryilmaz, Yilmaz Yucehan Yazici, Radu Marches, Eleni P Mimitou, Lisa Kenyon-Pesce, Kim Handrejk, Sonia Jangra, Michael Schotsaert, Adolfo García-Sastre, George A Kuchel, Jacques Banchereau, Duygu Ucar

Faculty Research 2026

BACKGROUND. The SARS-CoV-2 pandemic provided a rare opportunity to study how human immune responses develop to a novel viral antigen delivered through different vaccine platforms. However, to date, no study has directly compared immune responses to all 3 FDA-approved COVID-19 vaccines at single-cell multiomic resolution.

METHODS. We longitudinally profiled SARS-CoV-2–naive adults (n = 31) vaccinated with BNT162b2, mRNA-1273, or Ad26.COV2.S, integrating plasma cytokines, antibody titers, and single-cell multiomic data (DOGMA-Seq).

RESULTS. We discovered a distinct, transient IFN program termed ISG-dim, which emerged specifically 1–2 days after the first mRNA dose in approximately 10% of myeloid cells. This state was …

Structure–Activity Modeling And Hybrid Machine Learning-Based Prediction Of Bioactivity In Pyrazole Derivatives For Drug Discovery Applications, Kader Şahi̇n, Serhat Kiliçarslan, Serdar Durdaği, Emi̇n Saripinar

Turkish Journal of Biology

Background/aim: Pyrazole derivatives are of growing interest due to their diverse pharmacological activities. However, their biological activity is often highly sensitive to subtle structural modifications. Existing quantitative structure–activity relationships (QSAR) approaches frequently fail to capture the conformational flexibility and nonlinear structure–activity relationships (SAR) of such heterocyclic scaffolds, creating a gap in the accurate prediction of their biological profiles. Therefore, there is a strong need for more robust and predictive computational frameworks. This study addresses this gap by integrating four-dimensional (4D)-QSAR descriptors with hybrid machine learning (ML) techniques to improve predictive accuracy and provide a more reliable tool for structure-based drug …

February 23 Elections, Census & Redistricting Update, Jeffrey M. Wice

Elections, Census & Redistricting Updates

No abstract provided.

Unh Expert Offers Safe Shoveling Tips For Winter-Weary Residents, Robbin Ray

UNH Today Archive

No abstract provided.

Preparation, Characterization, And Antimicrobial Evaluation Of A Cefepime Derivative With Divalent Transition Metals, Zahraa A. Jaber, Israa H. Ibraheem, Sahar S. Hassan

Baghdad Science Journal

The Schiff base ligand (L)- 1-((7-((Z), was recently synthesized 2–(2-((Z)–5,5-diethyl2-(methoxyimino)acetamido)-2-(methoxycarbonyl)-2,6-dioxotetrahydropyrimidin-4(1H)-ylideneamino) thiazol-4-yl8-oxo-5-thia , the next mineral ions, Ni²⁺, Cu²⁺, Zn²⁺, and Co²⁺, are permitted to react with 1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-1-methylpyrrolidinium, leading to the formation of new metal complexes with distinct geometric shapes. By detecting the shifting in the azomethines band and the appearance of M-N and M-O bands, FT-IR confirmed the occurrence of coordination through N of azobenzene and two O atoms of beta lactam and ester, indicating the development of Schiff base complexes as well as the original Schiff base. Additionally, we can use …

Synthesis, Characterization And Photodegradation Study Of Titanium Dioxide Nanoparticles Mediated Using Melon Peel Extract, Mohamed Abdelkalik Hussain, Wadhah Naji Al Sieadi

Baghdad Science Journal

The importance of nanotechnology in protecting the environment is represented in multiple applications, including, for example, the green synthesis of nanoparticles (NPs), using the remains of plant parts, as well as photolysis application that used semiconductors NPs which showed a clear effect in treating water from organic pollutants, this study combines these two applications, in terms of green synthesis of titanium dioxide nanoparticles (TiO₂NPs) using melon peel (Cucumis melo L.) in sol-gel method, as well as, the photodegradation of methylene blue dye (MB) by using a new irradiation photoreactor device which has designed and implemented for …

Synthesis, Spectroscopic Characterization, And Photostability Studies Of A New Ligand Derivative Of 4-Bromobenzaldehyde And Its Metal Complexes, Enass J. Waheed, Ali Mudher Abdulkareem, Ibtisam Khalifa Jassim

Baghdad Science Journal

The new Schiff base ligand (L_B) was synthesized by reacting precursor (P) with 4-bromobenzaldehyde. This ligand formed three new complexes: [Pd(L_B)(H₂O)₂]Cl₂ (square planar) and [M(L_B)(H₂O)₂Cl₂].mCl₂ (octahedral), where m=0 for Co⁺² and 1 for Pt⁺⁴, upon reaction with the respective metal ions. Characterization of the ligand (L_B) and its metal complexes involved various techniques including ¹H- and ¹³C-NMR, FT-IR, UV-Vis spectroscopy, magnetic susceptibility measurements, CHNS analysis, and molar conductivity. The photo-stabilization of polymers aims to mitigate …

Meeting Specifications Of Sapo-34 Molecular Sieve With Multi-Templates For Mto Reaction: Kinetic And Experimental Study, Mazin Jasim Mohammed, Najwa Saber Majeed

Baghdad Science Journal

Light olefins become are important products for polymeric and petrochemical industries. Producing olefins from oil become ineffective due to highly production cost. An alternative method for producing olefins using methanol instead of oil source become an efficient process. SAPO-34 considered as a proper zeolite catalyst used in this field. For this purpose, there were many attempts to prepare it with microwave irradiation using DEA, TEA and MOR as templates. Fixed power of 800 W for 200 min was applied in crystallization step. XRD, BET, SEM, EDX, FTIR and TGA analysis were studied for preparing catalysts. XRD analysis showed that producing …

The Impact Of Vascular Endothelial Growth Factor, Neutrophil Gelatinase-Associated Lipocalin, And Interleukin-38 Food And Air Allergy Patients Following The Pandemic Of Covid-19 In Iraq, Esraa Hameed Khamees, Zaizafoon N. Nasif

Baghdad Science Journal

Allergies are a common health issue where the immune system reacts to substances in the environment that are normally harmless. This study further investigates the effects of vascular endothelial growth factor (VEGF), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-38 (IL-38), immunoglobulin E (IgE), and the neutrophil-lymphocyte ratio (NLR) in these individuals, offering insight into the probable processes behind allergic responses following the pandemic. The study comprised 120 non-vaccinated females with previous COVID-19 infection. Groups included controls and food and air (F&A) allergic patients, with 60 individuals matched for age and gender. Serum levels of IL-38, VEGF, IgE, and NGLA were assessed using …

Investigating Interleukin-19 And Interleukin-33 In Breast Cancer Of Iraqi Women: An Immunohistochemical Study, Fouad Najm Abed, Suhad Saad Mahmood

Baghdad Science Journal

Cytokines are immune elements that have been found as marker either for tumor-promoting or inhibiting effects on breast tumor development, depending evidently on their exact quantities as well as the existence of additional modifying variables. The study aims to evaluate the relationship between breast cancer tissue and the expression level of IL-19 and IL-33. This study includes using breast cancer tissue (30 specimens) and normal breast tissue (20 specimens) to analyze the expression level of IL-19 and IL-30. Using immunohistochemical technique, the results indicated that lL-33 and also IL-19 were strongly elevated in patients with stage II and stage III …

A New Prospective Of Colistin Resistance Profile Of Some Staphylococcus Species Isolated From Iraqi Wound Fractured Foot, Zahraa M. Fadhil, Halah H Al-Haideri

Baghdad Science Journal

Sulbactam belongs to β-lactamase inhibitors that are more commonly used for Gram-negative bacteria than Gram-positive bacteria. In this study, nine different species of Staphylococcus (S. aureus, S. epidermidis, S.hominis, S. lentus, S. pseudintermedius, S. lugdunensis, S. haemolyticus, S. sciuri , and S. warneri. were isolated from wounded-fractured feet of Iraqi patients. The spectrum of activity of sulbactam and colistin against all isolates was evaluated. Surprisingly, among S. aureus isolates, 5 (12) isolates were sensitive to colistin, whereas, all bacterial isolates were completely resistant to sulbactam. Here, our study revealed that combining …

Assessment Of Histopathological Features Of The Placenta And Plasma Level Of Βhcg, Estrogen, And Progesterone In First-Trimester Spontaneous Miscarriage, Russul Hameed Hassan, Mukhtar K. Haba

Baghdad Science Journal

Miscarriage is a distressing complication with many fetal and maternal abnormalities. About 15% of pregnancies end in spontaneous miscarriages, and over 80% of these occur in the first 12 weeks of gestation. This research aims to evaluate the changes in the hormonal status in addition to determining the types and incidences of abnormalities in the decidua and chorionic villi of placentas that have been aborted. The peripheral blood samples were collected from twenty normal pregnant women as a control group and 30 aborted women. The obstetric characteristics results showed that the patients' mean maternal age was 25.73 ± 7.32 years …

Intraspecific Meristic Variation In Gambusia Holbrooki From The Middle East And Its Implications For Stock Structure And Taxonomic Status, Fatema A. Al Fatle, Ana L. Ibaňez, Laith A. Jawad

Baghdad Science Journal

An analysis was conducted on the variation in the counts of seven meristic traits of the eastern mosquito fish, Gambusia holbrooki, using samples collected from ten different sites in the Middle East. These sites are located along the Tigris, Euphrates, and Shatt al-Arab Rivers, spanning across Iraq, Iran,Türkiye, and Syria. The study revealed a northward increase in the average values of these meristic traits, with the highest recorded in Türkiye and the lowest in the southern region of Iraq. The statistical analysis using Boxplots demonstrated that the seven meristic features were distinct across different rivers, with no overlap observed. …

Green Synthesis And Characterization Of Prepared Copper Iodide (Cui) Nanoparticles Using Red Cabbage Extract, A. S. Abd-Alsada, Zainab J. Shanan, Aqel Mashot Jafar

Baghdad Science Journal

Copper iodide nanoparticles, CuI NPs, are one of the promising materials for use in many electronic applications. In this work, transparent CuI nanoparticles were prepared by the green force synthesis, which was done by red cabbage extract used not only as a reduction but also as a capping agent to reduce the toxicity in the preparation of CuI nanostructures. The structural properties were investigated by the X-ray diffraction analysis technique, XRD. The X-ray analysis shows the structure has a polycrystalline nature with a cubic phase and appears to have a preferential orientation direction along the (111) plane. Atomic force microscopy …

Relatively Prime Detour Domination Number Of Switching Certain Special Graphs, C. Jayasekaran, L. G. Binoja

Baghdad Science Journal

A set S ⊆ V is said to be a relatively prime detour dominating set of a graph G if it has at least two members is a detour set and a dominating set for any pair of vertices b and w such that (deg(b), deg(w)) = 1. The lowest cardinality of a relatively prime detour dominating set is indicated by γ_rpdn (G) and defines the lowest cardinality of a relatively prime detour dominating set of order γ_rpdn (G) said to as a γ_rpdn-set of G. If there is no relatively prime detour dominating set, the …

Clinician Tele-Mental Health Attitudes In North American Indigenous Communities, Elleh A. Driscoll, Justin Douglas Mcdonald

Journal of Indigenous Research

This study examined mental health clinicians (n=104) serving North American Indigenous clients and how tele-mental health (TMH) factors during and after the COVID-19 pandemic impacted future willingness to continue TMH. Results indicated predictors of future TMH usage were not statistically significant due to the high baseline of willingness to utilize TMH, regardless of factors. The goal of this study was to investigate awareness of clinician attitudes of TMH and promote continued research and training for tele-mental health care with Indigenous populations.

Dose-Dependent Ifn Programs In Myeloid Cells After Mrna And Adenovirus Covid-19 Vaccination., Giray N Eryilmaz, Yilmaz Yucehan Yazici, Radu Marches, Eleni P Mimitou, Lisa Kenyon-Pesce, Kim Handrejk, Sonia Jangra, Michael Schotsaert, Adolfo García-Sastre, George A Kuchel, Jacques Banchereau, Duygu Ucar

Faculty Research 2026

BACKGROUNDThe SARS-CoV-2 pandemic provided a rare opportunity to study how human immune responses develop to a novel viral antigen delivered through different vaccine platforms. However, to date, no study has directly compared immune responses to all 3 FDA-approved COVID-19 vaccines at single-cell multiomic resolution.METHODSWe longitudinally profiled SARS-CoV-2-naive adults (n = 31) vaccinated with BNT162b2, mRNA-1273, or Ad26.COV2.S, integrating plasma cytokines, antibody titers, and single-cell multiomic data (DOGMA-Seq).RESULTSWe discovered a distinct, transient IFN program termed ISG-dim, which emerged specifically 1-2 days after the first mRNA dose in approximately 10% of myeloid cells. This state was characterized by ISGF3 complex activation and …

Influence Of Film Formation Kinetics On The Dispersion Of Colloidal Quantum Dots In Organic Small Molecule Matrices, Rachel C. Kilbride, Michael P. Weir, James Xiao, Simon A. Dowland, Jurjen F. Winkel, John E. Anthony, Akshay Rao, Richard A.L. Jones, Anthony J. Ryan, Daniel T.W. Toolan

Chemistry Faculty Publications

Improving the dispersion of colloidal quantum dots (QDs) within organic semiconductor (OSC) matrices remains critical for advancing hybrid nanocomposite optoelectronic technologies. This study investigates how film-deposition kinetics influence the morphology of TIPS-tetracene (TIPS-Tc):PbS QD blends, comparing spin-coating and blade coating for QDs ligated with either native oleic acid (OA) or a matched carboxylic acid functionalised tetracene analogue (TET-CA). Films spun-cast at low spin speeds form highly crystalline TIPS-Tc domains with highly aggregated QDs. Increased spin speed induces a deeper solvent quench, driving rapid TIPS-Tc nucleation while kinetically arresting QD diffusion, which improves QD dispersion within the crystalline matrix. TIPS-Tc:PbS-OA blends …

The Third Annual Blockchain Tax Conference On January 30, 2026: Legislative And Administrative Updates (Tax And Non-Tax), An Thai

The Contemporary Tax Journal

No abstract provided.

University Of Northern Iowa Faculty Senate Meeting Minutes, February 23, 2026, University Of Northern Iowa. Faculty Senate.

Documents - Faculty Senate

Meeting minutes from the Faculty Senate of the University of Northern Iowa.

Vol. 70, No. 7 (February 23, 2026)

Indiana Law Annotated

No abstract provided.

Faculty Senate Xxx 2025-2026 - February 23, 2026 Agenda, Faculty Senate

Faculty Senate Agendas & Minutes

No abstract provided.

University Of New Hampshire 2025-2026 Faculty Senate Xxx - February 23, 2026 Minutes Summary, Faculty Senate

Faculty Senate Agendas & Minutes

No abstract provided.

Positional Differences In Internal And External Match-Play Loads Among Njcaa Division Ii Women's Soccer Players, Shannon Baisden

Doctorate in Kinesiology

This study quantified and compared the internal and external match-play demands of female community college soccer players by position during competitive match play. Using a retrospective observational design, GPS- and heart-rate–derived data were analyzed across eight regular-season matches from one NJCAA Division II women's soccer team. Nineteen outfield players were classified as defenders, midfielders, or forwards. Internal load was assessed using heart-rate metrics and time spent in intensity zones, while external load was measured using total distance and proprietary workload metrics. Linear mixed-effects models were employed to evaluate positional differences while accounting for repeated measures. Results revealed clear positional trends …

Re: Approval Letter For The Final Repository Siting Study (Rss) Detailed Evaluation And Recommendations Report (Dated February 11, 2026), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Supplementary Table 3. Colostrum Fatty Acid Yield (G) For Cows Supplemented –40 Meq/Kg Dm Dcad Diet +/- 23 G/D Nicotinic Acid Or –80 Meq/Kg Dm Dcad Diet +/- 23 G/D Nicotinic Acid For 28 D Prepartum, Tess Stahl, J. Kraft, Sarah Allen, Peter S. Erickson

Faculty Publications

No abstract provided.

Supplementary Table 1. Fatty Acid Methyl Esters (% Of Colostrum) For Cows Supplemented –40 Meq/Kg Dm Dcad Diet +/- 23 G/D Nicotinic Acid Or –80 Meq/Kg Dm Dcad Diet +/- 23 G/D Nicotinic Acid For 28 D Prepartum, Tess Stahl, J. Kraft, Sarah Allen, Peter S. Erickson

Faculty Publications

No abstract provided.

Quenching-Based Electrochemiluminescence Detection Of Chlorpyrifos Using A Portable Sensor Platform, Emre Dokuzparmak

Turkish Journal of Biology

Background/aim: Chlorpyrifos (CPF) is an organophosphate pesticide extensively used in agriculture, posing significant threats to human health due to its neurotoxic effects. Its presence in food products has raised considerable public health concerns, necessitating the development of rapid, sensitive, and reliable detection methods. This study aims to design and validate an electrochemiluminescence (ECL) sensor platform operating via a quenching-based mechanism to enable ultrasensitive detection of CPF in food matrices.

Materials and methods: The sensing strategy exploits the coreactant mechanism between 2-(dibutylamino)ethanol (DBAE) and [Ru(bpy)₃]²+ (tris(2,2′-bipyridyl)ruthenium(II)), wherein CPF suppresses the ECL emission by interfering with the excited-state electron transfer pathway. The …

Investigation Of Antimicrobial Synergism Of Actinomycin Derivatives From Streptomyces Parvus 35m1 Against Escherichia Coli Atcc 25922, Özge Can, Mustafa Ünver Kurt, Meli̇s Küçüksolak, Ataç Uzel, Erdal Bedi̇r

Turkish Journal of Biology

Background/aim: Limited drug development and increased antibiotic tolerance among Gram-negative bacteria have led researchers to consider combination therapy. Actinomycin derivatives, particularly actinomycin D, exhibit a wide range of bioactivities, including antibacterial effects. However, actinomycin D is less effective against Gram-negative pathogens. Therefore, it is essential to demonstrate the synergy of actinomycin D and its derivatives with clinically known antibiotics against Escherichia coli ATCC 25922 and investigate the effects on cellular morphology.

Materials and methods: Streptomyces parvus 35M1 isolated from coastal sediment in İzmir/Türkiye was identified via genome sequencing. Large-scale (30 L) fermentation followed by chromatographic purification yielded compounds 1 (actinomycin …

Transcriptomic Identification And Developmental Mapping Of Nrg3b Expression In Zebrafish, Elham Tarahomi, Nuray Soğünmez Erdoğan

Turkish Journal of Biology

Background/aim: Neuregulin 3 (NRG3) is an epidermal growth factor-like ligand that is involved in neuronal circuit formation in mammals. However, the expression profile of its zebrafish ortholog, nrg3b, remains poorly defined. The transcriptomic analyses of zebrafish sco-spondin mutants, which display alterations in their neurodevelopmental pathways, have indicated potential dysregulation of Nrg3b. Guided by these insights, this study aimed to characterize the temporal and spatial expression patterns of nrg3b in vivo in embryonic and adult zebrafish.

Materials and methods: Publicly available RNA-seq data from heterozygous and maternal-zygotic zebrafish sco-spondin mutants at 5, 15, and 30 days postfertilization (dpf) were analyzed to …