Digital Commons Network^™

Does Valsartan Affect The Cytotoxicity Of Doxorubicin When Used As A Cardioprotective Drug Against Doxorubicin-Induced Cardiotoxicity ?, Shaymaa Fadhil Abbas, Ahmed Bader Abdulwahid, Duha Emad Omran, Nehaya Mnahi Al-Aubody, Mohammad Fawzi Albadran

Iraqi National Journal of Medicine

Background: Doxorubicin is widely used as a chemotherapeutic drug. It has several serious side effects, including cardiotoxicity. Valsartan is an angiotensin II receptor blocker that plays a cardioprotective role against doxorubicin-induced cardiotoxicity. Aim: The aim of our study is to evaluate whether the combination of valsartan and doxorubicin affects the therapeutic efficacy of doxorubicin in treating cancer using an in vitro breast cancer cell line (MCF-7). Methods: Different concentrations of doxorubicin, valsartan, and their combination were tested to detect their cytotoxic effects on the cell line using MTT colorimetric assay method. Three duplicates of each concentration and control were made. …

Mean Platelet Volume (Mpv), Mean Platelet Count, And Red Blood Cell Distribution Width (Rdw) In Acute Coronary Syndrome (Acs), Jenan Al Ansary, Amani Hameed Abdulsahib, Ruqia Hameed Abdulsahib, Iman Abdulrasool Bachay

Iraqi National Journal of Medicine

Background: Red blood cell distribution width (RDW) reflects anisocytosis, which is the variability in erythrocyte size. This parameter is commonly used in the differential diagnosis of various types of anemia Mean platelet volume (MPV) demonstrates platelet size and serves as an indirect marker of platelet activation. Both RDW and MPV have been proposed as potential markers for cardiovascular disease severity and prognosis. Aim: To evaluate the role of RDW, MPV, and the MPV/PLT ratio as supporting indicators in the diagnosis and severity assessment of acute coronary syndrome (ACS). Methods: This cross-sectional hospital-based study included 104 patients diagnosed with ACS (ST-elevation …

Clinical Characteristics And Outcomes Of Acute Coronary Syndrome In A Group Of Patients In Slemani Cardiac Hospital, Khakan Radha Rostem, Amanj Kamal Muhammad, Hamza Hakim Abdullah, Renas Othman Hamad

Iraqi National Journal of Medicine

Background: Acute coronary syndrome (ACS) is a subcategory of coronary artery disease (CAD) that encompasses a range of thrombotic cardiovascular events and remains a significant cause of morbidity and mortality worldwide. The clinical characteristics and outcomes of ACS patients can vary significantly based on geographical location, healthcare facilities, and population demographics. These variations highlight the importance of region-specific studies to better understand the presentation, management, and outcomes of ACS in diverse populations. Aim: This study aimed to evaluate the demographic profile, cardiovascular risk factors, seasonal variations, clinical presentations, and in-hospital outcomes of ACS patients admitted to Slemani Cardiac Hospital. Methods: …

Platelet Count Pitfalls Between Routine And Advanced Techniques, Dhuha Ali, Sadiq Khalaf Ali

Iraqi National Journal of Medicine

Background: Precise quantification of platelet counts is a fundamental aspect of clinical hematology, pivotal in diagnosing and managing conditions such as thrombocytopenia and thrombocytosis. However, inconsistencies in platelet measurements across various automated hematology analyzers present significant challenges, potentially compromising the reliability of results. This variability is especially critical when platelet counts inform urgent clinical interventions, including the administration of platelet transfusions. Aim: The present study evaluated the accuracy of Sysmex XN-350 and Mindray in comparison to flow cytometry, the gold standard for platelet counting. Methods: 120 blood samples were categorized into thrombocytopenic, thrombocytosis, and normal groups. Platelet counts were measured …

A New Vitamin D Deficiency Cut-Off Value In Basrah, Iraq, Majid Alabbood, , Haider Alrubaye

Iraqi National Journal of Medicine

Background: Vitamin D deficiency is a common health issue worldwide. Clinical observations have shown that most healthy individuals living in Iraq and the Middle East are vitamin D deficient. This study aimed to establish the true cut-off value for vitamin D deficiency (25(OH)D) in Basrah, Iraq, by analyzing the value at which parathyroid hormone (PTH) begins to rise above its reference range. Aim: This study sought to determine the true cut-off value for vitamin D deficiency (25(OH)D) in Basrah, Iraq by analyzing the value at which PTH starts to exceed its reference range. Methods: A cross-sectional study was conducted involving …

The Pattern Of Immunoglobulin Production In Secretory Myeloma And The Relationship Between Relevant Hematological And Clinical Parameters In Basrah, Mays Husseinawi, Sadiq Khalaf Ali

Iraqi National Journal of Medicine

Background: Plasma cell disorders encompass a spectrum of diseases ranging from benign to malignant. Among malignant plasma cell disorders, multiple myeloma is the most common and well-recognized entity. Aim: To identify the pattern of immunoglobulin production in secretory myeloma in Basra and correlate findings with hematological and clinical data. Methods: A retrospective study of 143 patients with plasma cell disorders was conducted at the Department of Pathology, Basrah Oncology Center, Iraq. Clinical data, relevant laboratory parameters (erythrocyte sedimentation rate, renal function tests, and serum calcium), bone marrow examination findings, radiological findings of bony lesions, and results from serum/urine protein electrophoresis …

Post-Induction Minimal Residual Disease Study By Flow Cytometry In Pediatric B All And Its Correlation With Initial Clinical And Laboratory Parameters, Huda Ali Alnaseri, Yassmin Ali Alaamiri, Hussam Mahmood Salih

Iraqi National Journal of Medicine

Background: Acute lymphoblastic leukemia (ALL) is a cancer characterized by the rapid and uncontrolled growth of immature lymphoid cells. Among its subtypes, B-lineage ALL in children represents the most frequently diagnosed malignancy in the pediatric population. Despite high survival rates, relapsed or refractory cases remain challenging. Minimal Residual Disease (MRD), detected by flow cytometry, is a strong prognostic marker that guides the intensity of post-induction therapy. Aim: This study aims to evaluate the correlation between post-induction MRD, measured by multicolor flow cytometry, and the initial clinical and laboratory parameters in pediatric patients with B-ALL. Methods: A retrospective cross-sectional study was …

Psychiatric Disorders Among Divorced People In Basrah, Jamal Abdulzahra, Rafal W. Khalid, Aqeel Ibraheem Al-Sabbagh

Iraqi National Journal of Medicine

Background: Divorce has been linked to increased psychiatric morbidity; however, studies in regions such as Iraq remain sparse. Despite the known mental health challenges that often follow divorce, the impact within the Iraqi context—shaped by unique cultural changes—demands focused exploration. Aim: This study aimed to estimate the prevalence of psychiatric morbidity among divorced individuals, identify psychiatric disorders post-divorce, and assess the impact of various sociodemographic variables on psychiatric morbidity in this population. Methods: Employing a case-control design, this study was conducted in collaboration with local courts and psychiatric clinics in Basrah. A total of 154 participants, divided equally between divorced …

Clinical Evaluation Of Intraoperative Indocyanine Green (Icg) Fluorescent Cholangiography During Laparoscopic Cholecystectomy: A Comparative Study, Mariam Akeel, Issam Al-Najjari, Ali Dawood

Iraqi National Journal of Medicine

Background: Laparoscopic cholecystectomy (LC) is one of the most common surgical procedures performed globally. While it is generally considered safe, there remains a risk of serious biliary injuries occurring during the procedure. Indocyanine green (ICG) is a water-soluble, non-toxic dye that allows real-time intraoperative visualization of the extrahepatic biliary tree. Aim: This study aims to compare the bile duct injury rate, duration of surgery, conversion rate, length of hospitalization, and overall outcomes between laparoscopic cholecystectomy with and without indocyanine green (ICG).  Methods: Ninety-two patients who underwent LC from October 2023 to October 2024 were included in the study; 42 of …

Levels Of 8-Isoprostane And Advanced Oxidation Protein Products In Relation To Sperm Count And Motility, Ahmed Sulaiman, Sherwan Salih

Iraqi National Journal of Medicine

Background: Oxidative stress is implicated in male infertility, with reactive oxygen species contributing to sperm dysfunction. Among oxidative stress markers, 8-isoprostanes (8-isoP) and advanced oxidation protein products (AOPP) serve as indicators of lipid peroxidation and protein oxidation, respectively. However, their relationship with specific sperm abnormalities remains unclear. Aim: This study investigates the oxidative stress markers 8-isoprostane (8-isoP) and advanced oxidation protein products (AOPP) across different semen profiles and explores their correlation with sperm count and motility to evaluate their potential as diagnostic biomarkers in male infertility. Methods: A cross-sectional study was conducted on male partners of infertile couples between May …

Serum Iron Profile In Sudanese Patients Infected By Helicobacter Pylori, Rimaz Gurashi, Abuagla M. Dafalla, Suhair A. Ahmed, Shereen Faisal, Abdelkarim A. Abdrabo

Iraqi National Journal of Medicine

Background: Helicobacter pylori is a Gram-negative, spiral-shaped, motile bacterium that represents one of the most widespread chronic infections in humans, affecting nearly half of the global population. Iron is a vital micronutrient required for almost all living organisms, including H. pylori, which relies on iron to establish colonization. Although several studies have indicated an association between iron deficiency (ID) or iron deficiency anemia (IDA) and H. pylori infection, the precise mechanisms remain incompletely understood. Aim: To assess the serum iron profile among Sudanese patients with H. pylori infection. Methods: Analytical case‑control hospital-based study was conducted at Bahri Hospital, Khartoum state …

Measles Outbreak In Anbar Province During 2023-2024. Demographic Distribution And Vaccination Status, Rafi Alani, Mohammed Dawood

Iraqi National Journal of Medicine

Background: This is the first public study covering all cities in Anbar Province regarding the measles outbreaks occurred in 2023 and 2024. Aim: To estimate the demographic distribution of measles among infected children (age, gender, residence) in Anbar Province and to study the effectiveness of the measles vaccine for each patient on infection. Methods: A retrospective analytic cross-sectional study was conducted across all sectors of Anbar Province. The patients included those who were admitted, diagnosed, and treated in various hospitals during the measles outbreak in 2023, and 2024 years. The data was recorded in files of the Anbar Public Health …

Association Of Matricellular Protein, Growth Factor, And Transcription Factor With Molecular Subtypes Of Breast Cancer: A Case Control Study, Marwa Munther Homman, Eman Tariq Ali, Maitham Ali Alrikabi

Iraqi National Journal of Medicine

Background: Breast cancer is a heterogeneous disease comprising molecular subtypes such as Luminal A, Luminal B, Human Epidermal Growth Factor 2 (HER-2)-Enriched, and Triple Negative, each with distinct clinical, molecular, and immunological features. Immunological markers play a critical role in modulating tumor behavior, angiogenesis, and immune evasion. Aim: This study aimed to identify key immunological markers that correlate with the molecular (intrinsic) subtypes of breast cancer and to explore their potential as prognostic factors. Methods: Serum samples from 180 breast cancer patients (56 untreated and 74 treated) were analyzed using Enzyme-Linked Immunosorbent Assay (ELISA) to determine the levels of four …

Corrigendum: Prevalence Of High Tricuspid Regurgitation Jet Velocity In Patients With Sickle Cell Disease, Amer Al Mansory

Iraqi National Journal of Medicine

Post-publication Author Correction Following publication of the above article, the Editorial Office of the Iraqi National Journal of Medicine (IqNJM) received a formal request on 7 July 2025 from Dr. Assad Faisal Al-Kuheli requesting a correction to the authorship of the article, including removal of one author and rearrangement of the author sequence. Upon receipt of this request, the Editor-in-Chief initiated a formal investigation in accordance with the journal’s bylaws and authorship correction policy. As part of this process, Dr. Weal Al-Shehaby and the Editor-in-Chief contacted all originally listed authors as well as the newly proposed author, both directly by …

Desert Plant Endophyte Genome Database: A Curated Repository Of Endophytic Bacterial Genomes Across Arid Ecosystems, Sabiha Parween, Arun Prasanna Nagarajan, Amal K. Alghamdi, Abdul Aziz Eida, Feras F. Lafi, Luma Albanna, Nida Salem, Barakat Abu-Irmaileh, Zaid A. Pirzada, Shahid Siddique, Ruben Garrido-Oter, Paul Schulze-Lefert, Maged M. Saad, Heribert Hirt

All Works

Microbial communities associated with desert plants play a pivotal role in enhancing host survival under extreme environmental stressors, including drought, salinity, and nutrient limitation. The Desert Plant Endophyte Microbial Collection is one of the largest curated repositories of 2500 cultivable endophytic bacteria isolated from 23 native desert plant species across Saudi Arabia, Jordan, and Pakistan. Representing a broad spectrum of arid microhabitats from inland deserts and mountain wadis to coastal mangroves and date palm oases, the collection supports integrative studies on microbial ecology and plant-microbe interactions in water-limited ecosystems. A central component of this initiative is the Desert Plant Endophyte …

Writing From The Rift: Queer Temporality And The Refusal Of Resolution, Daniela Ruiz Perez

Masters Theses

This thesis develops a phenomenological method for reading speculative literature as a site where queer ecological temporality is experienced rather than explained. Working with Annihilation (2014) by Jeff VanderMeer, The Day of the Triffids (1951) by John Wyndham, and Undrowned: Black Feminist Lessons from Marine Mammals (2020) by Alexis Pauline Gumbs, the project treats reading as a bodily practice shaped by forms of attention. Texts are not interpreted for stable meaning and instead I remain with moments where resolution is withheld. The work is informed by a Marxist attention to how capitalist time organizes labor, productivity, and value, and how …

Within Boundaries: Collecting And Exhibiting Chinese Contemporary Art In M+, Hong Kong, Lei April Liu

Masters Theses

This thesis investigates how M+, Hong Kong’s museum of twentieth- and twenty-first-century visual culture, collects and exhibits Chinese contemporary art under political and institutional constraint. It argues that M+ operates through adaptive autonomy, a condition in which curatorial and educational strategies transform limitation into method. By analyzing the museum’s formation, exhibition practices, and comparison with other Asian institutions such as the Asia Culture Center in South Korea, the Power Station of Art in China, and the National Gallery Singapore, the study reveals how M+ sustains visibility of Chinese contemporary art with political sensitive topic through 绥靖 (Sui Jing; subtle appeasement) …

2026 January 15 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Re: Utility Of Routine 24-Hour Electrocardiographic Holter Monitoring For Detecting Atrial Fibrillation In Patients Admitted With Acute Stroke Syndromes, Sinda Zarrouk, Josef Finsterer

Sultan Qaboos University Medical Journal

No abstract provided.

The Impact Of Indigenous American-Like Ancestry On The Risk Of Acute Lymphoblastic Leukemia In Hispanic/Latino Children, Jalen Langie, Tsz Fung Chan, Wenjian Yang, Alice Y Kang, Libby Morimoto, Daniel O Stram, Nicholas Mancuso, Xiaomei Ma, Catherine Metayer, Philip J Lupo, Karen R Rabin, Michael E Scheurer, Joseph L Wiemels, Jun J Yang, Adam J De Smith, Charleston W K Chiang

Faculty, Staff and Students Publications

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, with Hispanic/Latino children having a higher incidence of ALL than other racial/ethnic groups. Among the genetic variants previously implicated in ALL risk, a number of them were found to be enriched in Indigenous American (IA)-like ancestries and inherited by many Hispanic/Latino individuals. However, due to potential confounding from environmental factors, the association between IA-like ancestry and risk for ALL has remained unclear. In this study, we characterized the impact of IA-like ancestry on overall ALL risk and on the frequency and effect size of known risk alleles, while accounting for …

Epigenome-Wide Association Study Meta-Analysis Of Bmi In African Americans, Kendra Ferrier, Mariaelisa Graff, Iain R Konigsberg, Maggie Stanislawski, Heather M Highland, Laura M Raffield, April P Carson, Eric Boerwinkle, Jill M Norris, Chris R Gignoux, Audrey E Hendricks, Sridharan Raghavan, Kari E North, Kristin L Young, Anne E Justice, Matthew A Allison, Mathew J Budoff, Silva Kasela, François Aguet, Joshua J Joseph, Charles Kooperberg, Stephen S Rich, Jerome I Rotter, Ethan M Lange, Leslie A Lange

Faculty, Staff and Student Publications

Despite considerable advances in identifying risk factors for obesity, gaps remain in our understanding about its etiology. Genetic variants explain only a small portion of variation in obesity-related traits such as body mass index (BMI). Epigenetic regulation, which controls gene expression and is influenced by environmental and genetic factors, may account for additional variability in BMI. Epigenetic studies of BMI have largely been conducted in European ancestry populations, despite the disproportionate burden of obesity in African Americans (AAs). We conducted a sex-stratified BMI epigenome-wide association study meta-analysis in AA participants from the Jackson Heart Study (n = 1,604) and …

Dna Methyltransferase Inhibitors In Hematological Malignancies And Solid Tumors, Valentin Wenger, Guillermo Garcia-Manero, Robert Zeiser, Michael Lübbert

Faculty, Staff and Student Publications

Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5-position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor suppressor genes, oncogenes, and other key regulatory genes. The first-generation DNMTi azacitidine and decitabine have demonstrated substantial efficacy in the treatment of medically non-fit, older patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy (IC), by virtue of their favorable safety profile. Despite these clinical achievements, however, single-agent DNMTi treatment …

C Elegans As A Tractable Infection Model For The Emerging Fungal Pathogen Candida Auris, Melissa Martinez, Melissa R Cruz, Danielle A Garsin, Michael C Lorenz

Faculty, Staff and Student Publications

Candida auris is an emerging multidrug-resistant fungal pathogen. The genetic factors contributing to the virulence, drug resistance, and stress-tolerant nature of C. auris are mostly unknown. Additional animal models of virulence are needed, especially those amenable to high-throughput analysis. The nematode Caenorhabditis elegans has been validated as an effective tool for studying multiple fungal and bacterial pathogens. We describe here a C. elegans infection model in which exposure to C. auris is lethal to worms with kinetics similar to killing by Candida albicans; in contrast to C. albicans, C. auris does not form hyphae, indicating distinct virulence mechanisms. …

Unilateral Cervical Spine Facet Fractures: Radiographic Predictors Of Instability, Erisha Tashakori, Reese Svetgoff, Jacob Siahaan, Norman Zheng, Nicholas Beckmann, James Showery, Ran Lador, Mark L Prasarn

Faculty, Staff and Student Publications

Study design: Retrospective cohort study.

Objective: The purpose of our study is to identify CT characteristics of unilateral cervical spine facet fractures that are predictive of instability on MRI.

Summary of background data: Management of isolated subaxial cervical spine facet fractures is typically based on the neurological status of the patient and perceived stability of the injury. It has been shown that the degree of ligamentous instability can help predict instability and need for surgery, and MRIs are increasingly being used to evaluate these injuries, but not always. While there are studies that evaluate radiographic characteristics of facet fractures on …

Bdcd: A Comprehensive Brain Disease Cell-Cell Communication Database, Xinyi Liu, Citu Citu, Gang Qu, Wendao Liu, Nitesh Enduru, Andi Liu, Chia-Hao Tung, Zhongming Zhao

Faculty, Staff and Student Publications

Dysregulated cell–cell communication (CCC) is increasingly recognized as a driver of brain disease pathology, contributing to neuroinflammation, synaptic dysfunction, and neurodegeneration. Nevertheless, existing resources remain limited in brain specificity, regional coverage, and functional annotation. To address this gap, we develop the Brain Disease Cell-cell communication Database (BDCD), the first comprehensive resource focused on CCC networks across major brain diseases. BDCD integrates 38 manually curated datasets, comprising 8 519 425 single cells from single-cell RNA-seq studies and 140 744 spots from spatial transcriptomic maps, spanning 14 brain regions and 13 canonical cell types covering Alzheimer’s disease, Parkinson’s disease, schizophrenia, bipolar disorder, …

Allan Leslie Combs: Celebrating The Life Of A Trickster And Pioneer In Consciousness Studies, Zeke Floro, Leila A. Kincaid

Journal of Conscious Evolution

The Journal of Conscious Evolution (JCE) is a peer-reviewed academic journal dedicated to exploring consciousness, conscious evolution, and transdisciplinary inquiry as they relate to human growth, transformation, and planetary well-being. Originally founded by Allan Leslie Combs (1942-2025), Professor Emeritus at CIIS, JCE highlights outstanding work from both students and professional scholars around the world. A distinguished author, teacher, and mentor, Combs devoted himself to the study of consciousness, authoring over 250 publications on consciousness and the brain, including Synchronicity, The Radiance of Being (which won the 1996 best book award from the Scientific and Medical Network) and Consciousness Explained Better. …

Serendipity In Psychiatric Discoveries: Historical Lessons And Future Imperatives For Clinical Observation, Stanley Lyndon, Vineeth P John

Faculty, Staff and Student Publications

Aims and method: Serendipity has driven many of psychiatry's most important treatments, yet contemporary systems may undermine clinicians' ability to notice and develop unexpected therapeutic effects. This selective narrative review synthesises landmark discovery stories, conceptual accounts of serendipity and contemporary case examples to clarify how chance observations become robust advances.

Results: Across historical and modern examples, serendipitous discoveries consistently reflected the interaction of unexpected events with prepared observers working in supportive institutional and research systems. We identify current barriers created by standardised care, funding and trial structures, and professional fragmentation, and outline a multi-level framework for cultivating serendipity through phenomenological …

Bridging Hypoxia And Vision Loss: The Emerging Role Of Connexins In Local And Systemic Eye Diseases, Xianping Zhang, Yalong Cheng, Jean X Jiang, Yuting Li

Faculty, Staff and Student Publications

Hypoxic eye diseases represent a pivotal yet often underappreciated contributor to the onset and progression of many retinal disorders. When hypoxia persists or exceeds the tissue's compensatory capacity, it triggers pathological retinal neovascularization, blood-retinal barrier disruption, and neuronal apoptosis, ultimately resulting in irreversible visual impairment. Connexins (Cxs) form gap junction channels and hemichannels and regulate retinal cell proliferation, differentiation, and survival, thereby playing a central regulatory role in the pathogenesis of hypoxic ocular diseases. In addition to gap junctions, Cx hemichannels promote transmission of molecules between intra- and extracellular environments, further influencing retinal homeostasis under hypoxic stress. This review synthesizes …

Comparing And Optimizing Hollow Fibre And Flat Sheet Vacuum Membrane Distillation, Hamed Kariman, Mehdi Khiadani, Hussein A. Mohammed

Research outputs 2022 to 2026

Membrane Distillation (MD) systems have the potential to tackle the growing global water demand. Within various MD systems, Vacuum Membrane Distillation (VMD) systems are particularly important in addressing this issue. Hollow Fibre VMD (HF-VMD) and Flat Sheet VMD (FS-VMD) are the two main configurations of VMD systems, where limited studies are available on their comparison and optimisation under identical operational conditions. This study firstly charts the mathematical modelling of HF-VMD and FS-VMD systems that have been developed, accounting for the amount of flux, Gain Output Ratio (GOR), Temperature Polarisation Coefficient (TPC), and Specific Thermal Energy Consumption (STEC) of both configurations …