Digital Commons Network^™

Kras4a And Kras4b Show Distinct Lipid-Dependent Regulation Of Ras-Raf Membrane Dynamics, Konstantia Georgouli, Jeremy O.B. Tempkin, Liam G. Stanton, Tomas Oppelstrup, Rebika Shrestha, Timothy S. Carpenter, Fikret Aydin, Xiaohua Zhang, Harsh Bhatia, Yue Yang, Que N. Van, Pedro Andrade Bonilla, Gulcin Gulten, Debanjan Goswami, Francesco Di Natale, Joseph R. Chavez, Joseph Y. Moon, Gautham Dharuman, Nicolas W. Hengartner, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

KRAS4a and KRAS4b are important regulators of signaling, and their interactions with the plasma membrane are dynamic and influenced by lipid composition. KRAS 4a and 4b have nearly identical globular domains but differ in their membrane-associated hyper variable region (HVR). The functional distinctions between these isoforms remain unclear, particularly with regards to their dependence on specific lipids and the membrane environment. Previous work showed that the membrane orientation of KRAS4b affects its ability to bind to RAF kinase RBDCRD and that the KRAS–RBDCRD complex adopts different poses on the membrane as well as influences the size and composition of the …

When Superstition Outperforms Truth: Belief Transmission, Sacrifice, And Cooperation Under Environmental Uncertainty, Aidin Hajikhameneh

Faculty Research, Scholarly, and Creative Activity

We report results from an intergenerational experiment investigating how prosocial beliefs, whether accurate or false, emerge, spread, and support cooperation under environmental uncertainty (N=448, university students). In a repeated public goods game with randomly determined but ambiguously framed payoff shocks, participants often formed superstitious beliefs linking generosity to rewards. Compared to accurate beliefs, these superstitious beliefs, when transmitted to the next generation and internalized, led to greater cooperation and facilitated group formation via voluntary sacrifice. Individuals who held such beliefs were more likely to sacrifice and self-organize into high-functioning groups, achieving the highest levels of public good provision. These findings …

Thermodynamically Consistent Incorporation Of The Langmuir Adsorption Model Into Compressible Fluctuating Hydrodynamics, Hyun Tae Jung, Hyungjun Kim, Alejandro L. Garcia, Andrew J. Nonaka, John B. Bell, Ishan Srivastava, Changho Kim

Faculty Research, Scholarly, and Creative Activity

For a gas–solid interfacial system where chemical species undergo reversible adsorption, we develop a mesoscopic stochastic modeling method that simulates both gas-phase hydrodynamics and surface coverage dynamics by coupling the Langmuir adsorption model with compressible fluctuating hydrodynamics. To this end, we derive a thermodynamically consistent mass–energy update scheme that accounts for how the mass and energy variables in the gas and surface subsystems should be updated according to the changes in the number of molecules of each species in each subsystem due to adsorption and desorption events. By performing a stochastic analysis for the ideal Langmuir model and the full …

Global Value Chains And Economic Inequality, Vivek Soundararajan, Ari Van Assche, Hari Bapuji, Gokhan Ertug

Research Collection Lee Kong Chian School Of Business

In their inaugural editorial, Van Assche and De Marchi (2024) argued that meaningful progress in international business policy requires a more fine-grained understanding of how private international business practices intersect with public policy objectives. This editorial builds on that insight by applying it to a critical yet still underexplored issue – one on which we hope to see more research in this journal: the role of multinational enterprises (MNEs) and global value chains (GVCs) in shaping economic inequality within developing economies. Decisions related to sourcing, contracting, and GVC governance are inherently distributional rather than neutral, with important implications for how …

Unilateral Online Ultrasound Stimulation Of Early Visual Cortex Suppresses Responses To Contralateral Visual Stimuli, Suraya Dunsford, Keith Murphy, Ema Darrieutort, Elsa Fouragnan, Giorgio Ganis

School of Psychology

INTRODUCTION: Transcranial ultrasound stimulation (TUS) shows great promise for inducing neuroplastic changes that persist long after stimulation. Evidence of stimulation-locked (online) neural changes would enable the development of closed-loop application of TUS. However, such responses have been difficult to distinguish from coincident neural activity caused by auditory and somatosensory effects of TUS.

METHODS: To dissociate genuine online neuromodulatory effects from peripheral confounds, we leveraged the contralateral retinotopic organization of the early visual cortex in nineteen subjects. Using a hemifield visual stimulation paradigm combined with high-precision, functional MRI-guided TUS, we applied TUS to the left early visual cortex while participants viewed …

Automated Abdominal Aortic Calcification Scores And Atherosclerotic Cardiovascular Disease In The Uk Biobank Imaging Study, Marc Sim, James Webster, Cassandra Smith, Afsah Saleem, Syed Zulqarnain Gilani, Carlos J. Toro-Huamanchumo, David Suter, Gemma Figtree, Anne Karine Lagendijk, Emma L. Duncan, Carl Schultz, Pawel Szulc, Joseph Hung, Wai H. Lim, Parminder Raina, Nicola P. Bondonno, Richard Woodman, Jonathan M. Hodgson, Douglas P. Kiel, Richard L. Prince, William D. Leslie, John P. Kemp, Nicholas C. Harvey, John T. Schousboe, Joshua R. Lewis

Research outputs 2022 to 2026

Background: Abdominal aortic calcification (AAC) is a subclinical measure of atherosclerotic cardiovascular disease (ASCVD). AAC can be captured on lateral spine images obtained from bone density machines during routine osteoporosis screening. Identifying individuals with AAC provides a new opportunity to prevent disease progression. Objectives: The aim of the study was to externally validate a machine learning-derived AAC 24-point algorithm (ML-AAC24) with incident ASCVD. Methods: Middle-aged individuals from the UK Biobank Imaging Study with lateral spine images, obtained via dual-energy x-ray absorptiometry, were included. ML-AAC24 scores were grouped as low (<2), moderate (2 to <6), and high (≥6). Linked health records were used to identify ASCVD-associated events, including hospitalizations and death. Results: Among 53,611 participants (52% female; mean age 65 years), 78.2% had low, 16.4% had moderate, and 5.4% had high ML-AAC24. After excluding people with prevalent ASCVD or missing data, 1,163 (2.3%) of 50,923 people had an incident ASCVD event over a median follow-up of 4.1 [3.0-5.5] years. In age- and sex-adjusted analysis, compared to those with low ML-AAC24, those with moderate (HR: 1.80 [95% CI: 1.57-2.08]) and high ML-AAC24 (HR: 2.87 [95% CI: 2.39-3.44]) had a higher HR for incident ASCVD. Results remained comparable after adjustment for established ASCVD risk factors. Consistent patterns were observed when considering incident coronary artery disease, myocardial infarction, and stroke. Conclusions: Assessing ML-AAC24 on lateral spine images offers a new and promising screening method to identify people with higher risk of incident ASVD events.

Influence Of Exercise Training On Nitric Oxide Pathways And Their Physiological Effects, Jonas Benjamim, Stephen J Bailey, Leonardo Da Silva Gonçalves, Mia Burleigh, Mario Siervo, Andrew R Coggan, Raúl Bescos

School of Health Professions

Nitric oxide (NO) is a critical signalling molecule in cardiovascular, metabolic, and muscular function. Endogenous NO production occurs via two primary metabolic pathways: 1) the classical nitric oxide synthases (NOS) pathway, and 2) the alternative (nitrate-nitrite-NO) pathway, in which inorganic nitrate (NO 3 -) is sequentially reduced to nitrite (NO 2 -) and other NO intermediates (e.g., S-nitrosothiol). The latter pathway relies heavily on the oral microbiota, which catalyze the two-electron partial reduction of NO 3 - to NO 2 -, which is influenced by oral physiology, microbial composition and salivary flow. While the role of exercise training in enhancing …

Resurrecting Immigration Releases, Lindsay Nash

Articles

The nation’s “mandatory” immigration-detention laws sustain its largest civil-imprisonment system—and just radically expanded in scope and breadth. These laws consign broad swaths of suspected noncitizens to no-bail pretrial detention, denying tens of thousands of people facing civil regulatory charges any chance to prove they need not be detained. These laws turn split-second arrest decisions into jail sentences. They force people to give up meritorious claims. And they confound the historic presumptions—liberty, innocence, prosecutorial discretion, and bail—that undergird other pretrial-detention regimes. Although mandatory immigration detention conflicts with fundamental constraints on analogous detention regimes, the Supreme Court has treated it as exceptional …

Sidewalk Living, Michael C. Pollack

Articles

In City of Grants Pass v. Johnson, the Supreme Court held that the Eighth Amendment does not prohibit a city from enforcing a criminal ban on encampments on public property such as parks and sidewalks. But even if municipalities are now permitted to use tactics such as policing, encampment clearing, arrests, and imprisonment, these are not the right ways to address the problems of public homelessness.

Instead, homelessness must be understood as one of many conflicts over limited public space. At its best, vibrant sidewalk life enhances communities and local economies. But at its worst, every use of these finite …

Interest Fit Beyond The Riasec: The Comprehensive Assessment Of Basic Interests-O*Net (Cabin-Net), Chu Chu, Kevin A. Hoff, Zihan Liu, Nicholas F. Heimpel, Anthony Greco, Frederick L. Oswald, James Rounds

Research Collection Lee Kong Chian School Of Business

Over the past half-century, Holland’s RIASEC model has dominated vocational interest research. Although the RIASEC categories effectively capture general occupational themes, their breadth obscures meaningful variability across underlying basic interests, which are more refined interest scales. In this research, we adapted the Comprehensive Assessment of Basic Interests (CABIN; Su et ., 2019) to be used alongside O*NET for assessing interest fit, resulting in the 60-item CABIN-NET that measures 20 basic interest scales organized under RIASEC domains. In Study 1, we refined items for the CABIN-NET using a nationally representative adult sample (N = 768). In Studies 2 and 3, we …

Systematic, Bibliographic And Statistical Aspects On Multi Generation Recycled Concrete Materials Research: A Review, Henrique Comba Gomes, Maozhou Meng, Katie Jones, William Vevers, Aissa Bouaissi, Boksun Kim

School of Engineering, Computing and Mathematics

This article aimed to review the current literature related to the topic of multiple generation recycled concrete materials considering systematic, bibliographic and statistical aspects. The review was conducted from an adaptation from the systematic review for engineering and experiments (SREE) method. Papers wrote in English with scientific relevance, title and abstract full aligned with the topic were selected from Scopus and Web of Science databases. Bibliographic aspects highlighted the research novelty, the quality of research and prominence for future works. The systematic review aimed to provide insights in the literature concerning multiple recycling concrete materials. Some of the main aspects …

Mini-Course On Community Resources For Patients With Disabilities, Abigail Weisse, Vinita Kiluk, Kyle Lien, Nora Newcomb, Aishwarya Vuppala, Franklin Sun, Shannon Mccarthy, Anita Narkhede, Marjorie Fitzsimmons

USF-LVHN SELECT

No abstract provided.

Point-Of-Care Vision Correction: A Pilot Study Of Mobile Refractive Screening And Same Day Glasses Distribution In A Street Medicine Program, Tejasvi Paturu, Veena Jajoo, Emily Coughlin, Rebecca Lipscomb, Seth A. Campbell Pa-C

USF-LVHN SELECT

No abstract provided.

Socioeconomic Profiles And Barriers Among Committed Female Juveniles In The Florida Department Of Juvenile Justice, Aishwarya Vuppala, Kristopher Kaliebe, Sherry Jackson, Jorge Hernandez

USF-LVHN SELECT

No abstract provided.

A Retrospective Cohort Study Exploring Predictive Factors Of 30-Day Mortality In Intracerebral Hemorrhage Patients, Alan R Spicer, Veena Jajoo, Rahul Mhaskar, Marla Hairston, Crystal Dixon, W Scott Burgin

USF-LVHN SELECT

No abstract provided.

A Case Series Of Hypokalemia And Hypertension In Pregnancy, Pooja Neerumalla, Sharon E. Maynard Md, Sejal Lakhani Do

USF-LVHN SELECT

No abstract provided.

Sexually Transmitted Infections At A Health Clinic Serving Older Adolescents And Young Adults: An Analysis Of Demographics, Health Care Access, And Positivity Rates, Shaliz Aflatooni, Margaret Van Cleve, Anna Sizemore, Sarah A Commaroto, Emily Coughlin, Rahul Mhaskar, Carina A. Rodriguez, Lisa J. Sanders

USF-LVHN SELECT

No abstract provided.

Baseline Assessment Of Advance Care Planning Documentation Among High-Risk Ed Patients, Sierra Barber, Marna R. Greenberg Do, Mph, Facep

USF-LVHN SELECT

No abstract provided.

Subdural Hematomas At A Cancer Center: Large Retrospective Review Of Survival And Prognostic Indicators, Samuel Bauserman, Trevor Pharr, Samantha Schimmel, Bassel El Sayed, Alexander Becker, Andre Beer-Furlan

USF-LVHN SELECT

No abstract provided.

Enhancing Prenatal Detection Of Fetal Cardiac Pathologies Using Fetoly-Heart Software: A Performance Study, Alexander Behzadi, Sean Daneshmand, Arij Faksh, Mishella Perez

USF-LVHN SELECT

No abstract provided.

Assessing Evidence-Based Care In Hospitalized Lyme Disease: A Quality Improvement Study, Quentin Boose, Raul E Davaro Md

USF-LVHN SELECT

No abstract provided.

Examining Psychosocial And Demographic Correlates Of Sleep Disturbances At A Home For Youth Experiencing Housing Instability, Elizabeth G Chiu, Alisa Vidwans, Amy B. Smith Phd

USF-LVHN SELECT

No abstract provided.

Perspectives Of African American Mothers On Breastfeeding Support During Newborn Hospitalization: Addressing Disparities In Breastfeeding Exclusivity, Melissa Chow, Sarah A Commaroto, Kaen Fugate, Karyn Gerstle

USF-LVHN SELECT

No abstract provided.

Life After Parent Training: 3- And 6-Month Follow Up Of Hot Docs, Sarah A Commaroto, Sarah Dickinson, Heather Agazzi

USF-LVHN SELECT

No abstract provided.

Preoperative Neighborhood Socioeconomic Deprivation And Patient Reported Quality Of Life In Bladder Cancer Patients Undergoing Radical Cystectomy, Anosh Dadabhoy, Farshad S. Moghaddam, Siamak Daneshmand

USF-LVHN SELECT

No abstract provided.

Implementation Of A Visual Brochure Outlining Breastfeeding Policies To Improve Awareness For Employees At Lvhn, Karim Girgis, Autumn Kieber-Emmons Md, Mph

USF-LVHN SELECT

No abstract provided.

Bacillus Calmette-Guérin–Exposed Non–Muscle-Invasive Bladder Cancer: Survival Benchmarks, Bladder-Sparing Strategies, And Implications For Trial Design, Seyed Behzad Jazayeri, Renzo G. Dinatale, Christopher W Guske, Christian Harrs, Joshua Linscott, Hongzhi Xu, Facundo Davaro, Lexiaochuan Wen, Philippe E. Spiess, Wade J. Sexton, Scott M. Gilbert, Logan Zemp, Michael Poch, Roger Li

USF-LVHN SELECT

No abstract provided.

Does Treating Iron Deficiency Decrease Disease Severity And Improve Functionality For Rheumatoid Arthritis Patients?, Xinyi Jing, Emily Coughlin, Marie S. O’Brien Do

USF-LVHN SELECT

No abstract provided.

What Are We Doing Right? A Qualitative Analysis Of Health Disparity Conversations With Lgbtq+ Older Adults, Skylar Lung, Ashlee Randolph, Nyann Biery Ms, Lynn M. Wilson Do

USF-LVHN SELECT

No abstract provided.

Systemic Functioning Of Puerto Rican Families With A Cancer Patient: A Qualitative-Oriented Mixed-Methods Study, Nicole M. Velez-Agosto

Psychological Science Faculty Publications

Systemic family interventions of Latino families with a cancer patient have been suggested as effective and necessary, but few studies have focused on evaluating systemic functioning to design culturally relevant interventions. The purpose of study was to assess systemic functioning in Puerto Rican families with a cancer patient using the Spanish translated version of the Family Genogram Interview (FGI) that measures Bowen’s four emotional processes in nuclear family and family of origin. Fifty-one Puerto Rican participants related to a cancer patient were interviewed. Results suggested an acceptable reliability for the FGI-Spanish and higher presence of symptoms in a spouse or …