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Celebrate The Year Of Fire Horse With Apalsa, Asian Pacific American Law Students Association (Apalsa)

2025–2026 Flyers

Lunar New Year Celebration

Mechanometabolism Instructs Hematopoietic Stem Cell Specification, Paulina D Horton, Alina Syed, Michelle Winkler, Abishek B Vaidya, Michael Rariden, Yong Zhou, Momoko Yoshimoto, Hyun Jung Lee, Hyun-Eui Kim, John P Hagan, Catherine Denicourt, Travis I Moore, Pamela L Wenzel

Faculty, Staff and Student Publications

Mechanical force generated by blood flow stimulates emergence of the first hematopoietic stem cells (HSCs) that populate the blood system. Force drives the transition of HSC precursors from an endothelial to hematopoietic identity, yet the molecular regulation of this fate switch remains poorly understood. We report that shear stress triggers adaptation in mitochondrial composition, ultrastructure, and function, which are essential for hematopoietic fate and engraftment potential. Shear stress remodels mitochondria in hemogenic endothelium by promoting mitochondrial gene transcription and protein synthesis. Laminar flow selectively initiates translation of 5' terminal polypyrimidine (5'TOP) motif-containing transcripts, which commonly encode ribosome and translation machinery. …

Poly(Adp-Ribose) Glycohydrolase Enforces P21 Degradation Via Deparylation To Promote Gastric Cancer Progression, Yangchan Hu, Qimei Bao, Yixing Huang, Yan Wang, Xin Zhao, Yuxin Meng, Yuancong Li, Zirui Zhuang, Hanyi He, Dan Zu, Yuke Zhong, Chunkai Zhang, Bing Wang, Ran Li, Yanhua He, Qihan Wang, Min Liu, John A Tainer, Yin Shi, Xiangdong Cheng, Ji Jing, Zu Ye

Faculty, Staff and Student Publications

Dysregulation of cell cycle checkpoints is a cancer hallmark, with ubiquitination-controlled protein stability playing a pivotal role. Although p21, a key cyclin-dependent kinase inhibitor, is tightly regulated by ubiquitin-mediated degradation, the key upstream modulators of its ubiquitination remain incompletely defined. Here, we identify poly(ADP-ribose) glycohydrolase (PARG) as a regulator of p21 stability in gastric cancer (GC) cells. We show that PARG expression is markedly upregulated in GC tissues and correlates with poor patient prognosis. Functional assays revealed that genetic depletion of PARG triggers G2/M phase arrest and impairs GC cell proliferation. Mechanistically, we demonstrate that PARG loss enhances p21 PARylation, …

Dna Methylation Is Associated With Von Willebrand Factor And Coagulation Factor Viii Plasma Levels: The Atherosclerosis Risk In Communities Study, Julie Hahn, Jan Bressler, Myriam Fornage, Eric Boerwinkle, Nicholas L Smith, Paul S De Vries

Faculty, Staff and Student Publications

Background: Limited information is available on how DNA methylation of cytosine-phosphate-guanine (CpG) sites across the genome regulate circulating von Willebrand Factor (VWF) and factor VIII (FVIII) levels.

Methods: We performed an epigenome-wide association study to examine the association of leukocyte DNA methylation levels at 483,735 CpG sites with VWF antigen plasma levels and FVIII activity in 2,597 Black and 1,011 White participants from the Atherosclerosis Risk in Communities (ARIC) study. VWF antigen levels and FVIII activity were measured at the baseline exam, while DNA methylation was measured with the Infinium HumanMethylation450 BeadChip array at visit 2 or 3. Discovery analysis …

Ectopic B Lymphocyte Follicles Exacerbate Ischemic Brain Damage Via Mif-Cd74/Cxcr4 And Interferon Signaling, Sheng Yang, Hang Zhang, Lu-Lu Xu, Luo-Qi Zhou, Yun-Hui Chu, Xiao-Wei Pang, Li-Fang Zhu, Ming-Hao Dong, Ke Shang, Jun Xiao, Long-Jun Wu, Wei Wang, Dai-Shi Tian, Chuan Qin

Faculty, Staff and Student Publications

Neuroinflammation, encompassing both innate and adaptive immune responses, plays a crucial role in ischemic stroke. Although B lymphocytes are central to adaptive immunity, their contributions to ischemic stroke remain poorly understood. Here, we demonstrated that B lymphocytes accumulate in ischemic lesions, forming germinal center-like structures at the later stage after stroke, which mainly depended on in situ proliferation. This accumulation correlated with worsened neuroinflammation and ischemic injury, whereas B cell depletion reduced chronic brain damage during stroke. Mechanistically, microglia recruited B cells into ischemic lesions through MIF-CD74/CXCR4 signaling during the early phase of stroke, while IFN-related pathways in B cells …

Continuous Vs Intermittent Postoperative Vital Sign Monitoring: A Cluster Randomized Crossover Trial, Robert S Weller, Carolyn S Huffman, Scott Segal, Brian J Wells, Eric S Kirkendall, Daniel I Sessler

Faculty, Staff and Student Publications

Importance: Continuous postoperative monitoring on general nursing units detects vital sign abnormalities that are missed with conventional intermittent monitoring. Early recognition may prompt interventions to limit potentially harmful blood pressure, heart rate, and oxygen saturation perturbations.

Objective: To test the hypothesis that continuous unblinded monitoring of vital signs would decrease blood pressure, heart rate, and oxygen saturation abnormalities compared with intermittent monitoring in patients recovering from noncardiac surgery.

Design, setting, and participants: This multiple crossover randomized cluster trial in 2 postoperative hospital wards included patients recovering from noncardiac surgery and was conducted from October 7, 2020, to October 7, 2021. …

Surface Morphometrics Reveals Local Membrane Thickness Variation In Organellar Subcompartments, Michaela Medina, Ya-Ting Chang, Hamidreza Rahmani, Mark Frank, Zidan Khan, Daniel Fuentes, Frederick A Heberle, M Neal Waxham, Benjamin A Barad, Danielle A Grotjahn

Faculty, Staff and Student Publications

Lipid bilayers form the basis of organellar architecture, structure, and compartmentalization in the cell. Decades of biophysical, biochemical, and imaging studies on purified or in vitro-reconstituted liposomes have shown that variations in lipid composition influence the physical properties of membranes, such as thickness and curvature. However, similar studies characterizing these membrane properties within the native cellular context have remained technically challenging. Recent advancements in cellular cryo-electron tomography (cryo-ET) imaging enable high-resolution, three-dimensional views of native organellar membrane architecture preserved in near-native conditions. We previously developed a "Surface Morphometrics" pipeline that generates surface mesh reconstructions to model and quantify cellular membrane …

The Development Of Ace-Iii Performance Validity Tests For Dementia Screening, Donnchadh Murphy, Rupert Noad

Peninsula Medical School

Objective: Performance validity tests (PVTs) are an essential component of a neuropsychological evaluation. There is a lack of brief validated PVTs for use alongside cognitive screening assessments for dementia. The current study sought to develop and evaluate a series of brief PVTs, which could be embedded into the Addenbrooke’s Cognitive Examination (ACE-III) and used in a dementia clinic. Method: This study used a diagnostic accuracy design to compare the performance of 31 individuals with Alzheimer’s disease dementia and 26 healthy older adults who simulated having Alzheimer’s disease. Participants were asked to complete ACE-III, the Test of Memory Malingering (TOMM), and …

Political Mediatization In The Digital Era: The Case Of Walhi West Sumatera’S Environmental Advocacy, Muhammad Thaufan Arifuddin, Ernita Arif, Yuliandre Darwis, Rinaldi Rinaldi, Muhammad Al-Amin Dalmenda

JURNAL KOMUNIKASI INDONESIA

This article examines how political mediatization operates at the local level through environmental civil society activism in post-authoritarian Indonesia. Focusing on the West Sumatra chapter of the Indonesia Forum for Environment (WALHI) as a critical case, the study argues that media logic is not merely imposed by political elites or mainstream media, but is strategically appropriated by local civil society organizations to contest oligarchic power, shape public agendas, and sustain democratic engagement at the subnational level. Using a qualitative case study approach, data were collected through participant observation, in-depth interviews with environmental activists and youth organizers, and an analysis of …

Comparison Of Integrated 3d Electroanatomic Mapping And Conventional Mapping Systems For Pentaspline Pulsed Field Ablation Of Atrial Fibrillation., Auroa Badin, Andrea K Robinson, Allyson Farrah, Saanvi Billakanty, David M Nemer, Ankur N Shah, Jaret D Tyler, Eugene Y Fu, Nagesh Chopra, Anish K Amin

Heart and Vascular Articles

INTRODUCTION: Pulsed field ablation (PFA) is an established therapy for atrial fibrillation (AF), yet optimal mapping strategies during pentaspline PFA remain uncertain. We compared procedural characteristics and material costs of an integrated 3D electroanatomic mapping (EAM) platform with conventional mapping systems.

METHODS AND RESULTS: In a multicenter observational study of 448 consecutive AF ablations done using pentaspline catheter (62 integrated mapping; 386 conventional mapping) performed between February 2024 and August 2025, baseline characteristics were similar between groups. Compared with conventional mapping, the integrated platform was associated with shorter total procedure time (49 ± 16 vs. 66 ± 26 min, p …

Pediatric H3 G34-Mutant Diffuse Hemispheric Glioma: Clinical, Imaging And Molecular Prognostic Factors, Mgmt Expression, And Temozolomide Response., Dana Tlais, Qunyu Zhang, Jordan T. Roach, Christopher L. Tinkle, Tong Lin, Xiaoyu Li, Ayatullah Mostafa, Daniel C. Moreira, Rene Y. Mcnall-Knapp, Sarah Z. Rush, Brian H. Le, Sara Sinno, Apeksha Ramnarayan, Kevin Ginn, Sonia Partap, Arzu Onar-Thomas, Larissa V. Furtado, Asim K. Bag, Jason Chiang

Manuscripts, Articles, Book Chapters and Other Papers

Previous studies have demonstrated poor outcomes in pediatric patients with H3 G34-mutant diffuse hemispheric glioma (DHG). However, the biological basis for this therapeutic resistance remains poorly understood. Furthermore, the effectiveness of temozolomide (TMZ) and the role of surgery in pediatric patients remain uncertain. Therefore, we performed a multi-institutional retrospective analysis of the clinical, imaging, and molecular characteristics of 36 pediatric (≤ 18 years) patients with newly diagnosed H3 G34-mutant DHG. The median age of the cohort was 14 years (8-18 years). The median progression-free survival (PFS) was 0.7 years (95% CI 0.4-1.2 years), and the median overall survival (OS) was …

Activin A Secretion By Muscle-Repairing Macrophages Induces Heterotopic Ossification In Mice, Warunee Pluemsakunthai, Takehito Ono, Taku Ito-Kureha, Shizuo Akira, Yoshinobu Hashizume, Roland Baron, Satoshi Ueha, Kouji Matsushima, Martin M Matzuk, Yuji Mishina, Hiroshi Takayanagi

Faculty, Staff and Students Publications

The immune system is not only essential for host defense, but it is also involved in tissue maintenance and disease pathogenesis. Macrophages play a key role in tissue repair, fibrosis, and tumorigenesis, but the mechanisms underlying their multifunctionality have not been fully explored. Here, we identified Mrep (Ly6ChiCX3CR1loPDPN+CD9+) as a crucial subset of macrophages for muscle regeneration after muscle injury. Muscle regeneration required Mrep-derived activin A, which was produced via the TLR4/TIR domain-containing adapter-inducing interferon-β/TANK-binding kinase 1/interferon regulatory factor 3/7 signaling pathway in response to muscle injury. Mrep exerted pathological effects by secreting activin A in a model of genetically …

Regulating Ai In Pediatrics-Is Transparency Enough?

Faculty, Staff and Students Publications

No abstract provided.

Precision Measurement Of A Resistance Standard At Frequencies Up To 2 Mhz, Jurgen Schurr, Shakil A. Awan

School of Engineering, Computing and Mathematics

We report on two-terminal-pair and four-terminal-pair (4TP) measurements of a 10 kΩ resistance standard by means of a commercial precision inductance-capacitance-resistance meter (LCR meter) at frequencies up to 2 MHz. We discuss the effect of cables on a resistance standard measured in either two- or 4TP configuration and demonstrate within which uncertainty the effect of 2.5 m long measuring cables can be corrected accurately. Such long cables are inevitable for precision measurements of the quantum Hall resistance (QHR) at high frequencies. Furthermore, the systematic effects of the LCR meter, such as the internal input capacitances, voltage and frequency dependences, and …

Media Reporting Of The 2024 Us Preventive Services Task Force Mammography Guideline Update, Tamar Parmet, Yue Li, Joseph Cappella, Laura D Scherer, Erika A Waters, Ashley J Housten

2020-Current year OA Pubs

No abstract provided.

Shiga Toxin-Producing Escherichia Coli Outbreak In Canadian Daycare Centers, Mohamed Eltorki, Oluwatimilehin O Ajayi, Jina Seok, Jianling Xie, Francesco A Rizzuti, Byron M Berenger, Phillip I Tarr, Andrew T Pavia, Kate Snedeker, Silviu Grisaru, Otto G Vanderkooi, Linda Chui, Gillian A M Tarr, Gemma Vomiero, Stephen B Freedman

2020-Current year OA Pubs

IMPORTANCE: Shiga toxin-producing Escherichia coli (STEC) infections have significant morbidity, with 15% to 20% of children developing hemolytic uremic syndrome (HUS), more than half of whom require kidney replacement therapy (KRT).

OBJECTIVE: To describe health care resource utilization, clinical outcomes, and outcomes associated with daily laboratory monitoring for thrombotic microangiopathy (TMA) in a large point-source STEC outbreak.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study was conducted among a population-based cohort of individuals exposed to a contaminated food item served in 11 childcare centers in Calgary, Alberta, Canada, on August 29, 2023. Children and adults with confirmed STEC infection linked …

Trends In Mammography Use Among Women Aged 40 To 74 Years In The Us, 2002-2022, Syed Mahfuz Al Hasan, Debbie L Bennett, Adetunji T Toriola

2020-Current year OA Pubs

IMPORTANCE: Understanding how prior policies, systemic factors, and public health events have shaped mammography use among US women is essential for interpreting the 2024 US Preventive Services Task Force (USPSTF) recommendation update and identifying gaps to inform equitable public health strategies.

OBJECTIVE: To analyze mammography use trends in US women aged 40 to 49 and 50 to 74 years from 2002 to 2022 and assess variation by sociodemographic, health care access, behavioral, and geographic factors, including associations with the 2009 USPSTF recommendation and the COVID-19 pandemic.

DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used data from the Behavioral Risk Factor …

What Do Future Nutrition Professionals Think About Wic Jobs? A Study Of Nutrition Career Perceptions, Madison Degenfelder

Theses

Background: The Special Supplemental Nutrition Program for Women, Infants and Children (WIC) program faces a critical workforce shortage, yet little is known about the knowledge, attitudes, and beliefs of nutrition students and recent graduates regarding WIC career pathways, requirements, and compensation. Understanding these factors is essential to design strategies to strengthen recruitment and build a sustainable WIC workforce. Objective: To identify and describe knowledge, attitudes and beliefs on entering the WIC workforce among college nutrition and dietetics students and recent graduates. Design: A mixed-methods, sequential study design which included a cross-sectional survey and two focus groups was employed to ascertain …

Assessing The Readiness Of Oxford Nanopore Sequencing For Clinical Genomics Applications, Judith Arres, Santosh Elavalli, Shalini Behl, Daniel Matias Sanchez, Ayesha Al Ali, Abdelrahman Ahmed Yehia Abdelaziz Saad, Azza Attia, Cyla Minas, Sharika Pariyachery, Shariq Ahmed, Fatmah Aldhuhoori, Nitu Thulasidharan, Gurunath Katagi, Omar Soliman, Shilp Purohit, Vinay Kusuma, Raony Cardenas, Thyago Cardoso, Luis F Paulin, Philippe Sanio, Joseph Mafofo, Haiguo Wu, Val Zvereff, Albarah El-Khani, Fahed Al Marzooqi, Tiago R Magalhães, Fritz J Sedlazeck, Javier Quilez

Faculty, Staff and Students Publications

Long-read sequencing (LRS) technologies, namely, Oxford Nanopore Technologies (ONT) and Pacific Biosciences (PacBio), have emerged as promising solutions to overcome the limitations of short-read sequencing (SRS). Nevertheless, the still higher sequencing error rates compared with SRS, need for customized pipelines, rapidly updating software, and incipient scalability continue to present challenges for adopting ONT in standard clinical practice. Here we assess the performance of ONT (R9 and R10 chemistries) in comparison to Illumina and MGI across 17 well-characterized reference samples with 11 clinical variants representing nine different genetic diseases. To enable this, we have implemented a production-ready pipeline including SNV, indel, …

Co-Electrospinning Polyacrylonitrile (Pan) / Polymer Of Intrinsic Microporosity-1 (Pim-1) For Electrochemical-Based Sensor For Pyridine Detection And Absorption, Samar A. Salim

Nanotechnology Research Centre

The electrospinning of the polymer of intrinsic microporosity-1 (PIM-1) poses challenges due to its limited solubility and tendency to form bead-like structures at high concentrations. This work details the synthesis and analysis of electrospun composite fibers made from polyacrylonitrile (PAN) and PIM-1 for electrochemical applications. The data analysis confirmed the successful incorporation of PIM-1 into the PAN matrix. The fiber characteristics were significantly influenced by PIM-1 loading (1–10%), resulting in fiber diameters ranging from 0.8 to 1.7 μm. A 10% concentration of PIM-1 results in the formation of macropores with diameters ranging from 0.5 to 1.7 μm. Optical analysis using …

Effect Of Temperature Variation On The Biological Treatment Of Greywater In The Sequencing Batch Reactor, Ruaa M. Younis, Saad M. Hasan

Engineering and Technology Journal

Greywater reuse is vital in water-scarce regions, yet effective treatment remains challenging due to variable organic loads and limited infrastructure. This study investigates the effect of temperature variation on the efficiency of a Sequencing Batch Reactor (SBR) in treating greywater under realistic conditions. Greywater samples collected from households in Mosul, Iraq, were treated in a bench-scale SBR operated at 10, 23, and 36 °C with cycle times of 6, 8, and 12 hours. The reactor included aeration, temperature control, and sludge recirculation. Treatment performance was assessed through COD, TSS, nitrate, and pH analysis in influent and effluent samples. Results showed …

Keadaan Hukum Thalweg Dalam Hukum Laut, Ir. Adi Sumardiman, S.H.

Jurnal Hukum & Pembangunan

Abstract

Sosialisasi Hukum, Suatu Konsepsi Mengenai Pengembangan Penalaran Hukum, Ronny Hanitijo Soemitro, S.H.

Jurnal Hukum & Pembangunan

Abstract

Peranan Advokat Dalam Dunia Usaha, Mr. Nugroho

Jurnal Hukum & Pembangunan

Abstract

Penertiban Iklan Film, Wewenang Siapa ?, Bismar Siregar, S.H.

Jurnal Hukum & Pembangunan

Abstract

Testamen Yang Dibuat Warga Negara Indonesia Di Luar Negara, Prof. Dr. Mr. Sudargo Gautama

Jurnal Hukum & Pembangunan

Abstract

Hukum Lingkungan & Pengelolaan Lingkungan Laut Oleh Pemda Dki Jakarta, Zen Umar Purba, S.H., Ll.M.

Jurnal Hukum & Pembangunan

Abstract

Pembangunan Hukum Lingkungan (Dalam Mengiringi Terbitnya Dasawarsa Lingkungan Ke=Ii), Prof. Dr. Mr. St Munadjat Danusaputro

Jurnal Hukum & Pembangunan

Abstract

Tanggapan Atas Tulisan A. Hamid Attamimi: Pengertian Keuangan Negara Menurut Pasal 23 Ayat (5) Undang-Undang Dasar 1945, Jusuf L. Indradewa, S.H.

Jurnal Hukum & Pembangunan

Abstract

Logic, Experience, Dan Pengembangunan Hukum, M. Rachim Sjaian, S.H.

Jurnal Hukum & Pembangunan

Abstract