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Articles 811801 - 811830 of 5210891
Full-Text Articles in Entire DC Network
A Translation Assessment Of Metaphors In Elif Shafak's Black Milk, Farah A. Abo Al-Timen
A Translation Assessment Of Metaphors In Elif Shafak's Black Milk, Farah A. Abo Al-Timen
Alustath Journal for Human and Social Sciences
This study attempts to assess the translation of metaphors in Elif Shafak's Black Milk using a framework proposed by Peter Newmark (1981). Both the original and the translated texts are evaluated according to Newmark's strategies of rendering metaphors in order to determine whether the metaphorical image occurs at the same level or differently and to assess the strategies and translations made by the translator and their appropriateness. Based on the findings, the results show that the most dominant strategy is the literal strategy by (55%), followed by the sense strategy by (15.8%), then there is the mix strategy by (7.5%), …
The Binary Oppositions In Joseph Conrad's Novel Heart Of Darkness, Huda Kadhim Alwan
The Binary Oppositions In Joseph Conrad's Novel Heart Of Darkness, Huda Kadhim Alwan
Alustath Journal for Human and Social Sciences
The novel Heart of Darkness is regarded as one of Joseph Conrad's highly skilled works and seen as an important tale written between the years of 1898 - 1899, and also viewed as an assault on imperialism and unethical behaviors of the European colonizers in Africa in the nineteenth century. The novel displays the author's humanity towards the crimes of the colonists and imperialists throughout the world. In Heart of Darkness, Conrad shows the cruelty of colonialism in Africa through his major character, Charlie Marlow, who realizes the cruel manners of Belgian colonialism during his journey to the Congo …
The Scars Of Capitalism In Virginia Woolf’S Mrs. Dalloway And ‘Kew Gardens’, Median Mashkoor Hussein
The Scars Of Capitalism In Virginia Woolf’S Mrs. Dalloway And ‘Kew Gardens’, Median Mashkoor Hussein
Alustath Journal for Human and Social Sciences
This paper discusses the scars of capitalism in Virginia Woolf’s Mrs. Dalloway and ‘Kew Gardens’. Following one day of the character’s life, the discussion will investigate how the novel and the short story introduce the capitalist ideology that dictates the character’s everyday life and how the characters, in different ways and to certain extents, react to it. In Mrs. Dalloway, Woolf depicts capitalism as an oppressive system that can be very rewarding to those who submit to its ideals and, at the same time, very catastrophic to those who try to confront it or question its validity. In ‘Kew …
Political-Pedagogical Character Of The Collective Actions Of The Popular Bars, Magda Victoria Díaz Alzate Sra, Juan Pablo Menjura Acosta Sr, Maria Clara Fonseca Echeverri Sra
Political-Pedagogical Character Of The Collective Actions Of The Popular Bars, Magda Victoria Díaz Alzate Sra, Juan Pablo Menjura Acosta Sr, Maria Clara Fonseca Echeverri Sra
The Qualitative Report
Barrismo is a complex phenomenon and cannot be defined universally. Social representation is based on deficient conceptions that relate it to the use of psychoactive substances and violence. This article presents qualitative research evidence based on the epistemological assumptions of social constructionism, a hermeneutical phenomenological design and the use of qualitative interview and documentary and audiovisual review, to understand the political-pedagogical character of the collective actions of the popular bars of the city of Medellín, Colombia, as practices that contribute to the transformation of the territories. Categories found: i. Bars as popular movements: transition from the brave bar to the …
Lrg1 Is An Adipokine That Mediates Obesity-Induced Hepatosteatosis And Insulin Resistance, Sijia He, Jiyoon Ryu, Juanhong Liu, Hairong Luo, Ying Lv, Paul R. Langlais, Jie Wen, Feng Dong, Zhe Sun, Ravindranath Duggirala
Lrg1 Is An Adipokine That Mediates Obesity-Induced Hepatosteatosis And Insulin Resistance, Sijia He, Jiyoon Ryu, Juanhong Liu, Hairong Luo, Ying Lv, Paul R. Langlais, Jie Wen, Feng Dong, Zhe Sun, Ravindranath Duggirala
School of Medicine Publications
Dysregulation in adipokine biosynthesis and function contributes to obesity-induced metabolic diseases. However, the identities and functions of many of the obesity-induced secretory molecules remain unknown. Here, we report the identification of leucine-rich alpha-2-glycoprotein 1 (LRG1) as an obesity-associated adipokine that exacerbates high fat diet–induced hepatosteatosis and insulin resistance. Serum levels of LRG1 were markedly elevated in obese humans and mice compared with their respective controls. LRG1 deficiency in mice greatly alleviated diet-induced hepatosteatosis, obesity, and insulin resistance. Mechanistically, LRG1 bound with high selectivity to the liver and promoted hepatosteatosis by increasing de novo lipogenesis and suppressing fatty acid β-oxidation. LRG1 …
Psychological Assessment And Testing, Leslie A. Miller, Ruby Daniels
Psychological Assessment And Testing, Leslie A. Miller, Ruby Daniels
Marketing Faculty Publications (Archived)
No abstract provided.
Nesting Biology And Offspring Development Of The Cavity-Nesting Solitary Wasp Isodontia Elegans (F. Smith) From Trap-Nests In Oregon, Ronald C. Spendal, Kevin M. O'Neill, Casey M. Delphia
Nesting Biology And Offspring Development Of The Cavity-Nesting Solitary Wasp Isodontia Elegans (F. Smith) From Trap-Nests In Oregon, Ronald C. Spendal, Kevin M. O'Neill, Casey M. Delphia
Western North American Naturalist
We studied the nesting biology and developmental schedules of the cavity-nesting solitary wasp Isodontia elegans in Oregon, USA. Trap-nests contained 1–15 brood cells each, separated by partitions, which adult females made with grass fragments. Before leaving nests to hunt, females made loose, temporary closures of longer fragments of dried grass and, upon returning, briefly deposited prey just inside the nest entrance before transferring them to a cell. Cells were provisioned with katydids (Meconema thalassinum, an invasive species in North America) and tree crickets (Oecanthus fultoni), the latter predominating as summers progressed. The inner cells of nests, …
Pay Inequality And Gender Pay Gap, Chris Constantopoulos
Pay Inequality And Gender Pay Gap, Chris Constantopoulos
Student Theses and Dissertations
The topic of this thesis paper is pay inequality and gender pay gap, specifically within the United States while occasionally comparing Europe and other parts of the world. The research questions that are brought up while starting this thesis process were how the topic started and developed with the last 10 years. Plus, the potential strides to eliminate the thesis topics issues within the United States. The method of analysis for this thesis paper includes an integrative desktop literature review while analyzing various online and prior academic research articles. The result of studying the numerous amounts of research helped gather …
Leadership Conversion: From Command-And-Control To People-Centered Approach, Elli Unt
Leadership Conversion: From Command-And-Control To People-Centered Approach, Elli Unt
Student Theses and Dissertations
Leadership style is often recognized as the most important factor in determining workforce productivity and in establishing an organizational environment. In the last century, researchers have observed a significant shift in the approach organizational leaders take to communicate with their teams. This paper explores the gap between the leadership models of the last century (top-down approach) and more modern leadership practices (collaborative approach) in respect to economic and technological changes faced by organizations today. Through the analysis of knowledge and understanding about the subject shared by professionals from different fields, this paper proposes new ideas on how to better adapt …
Review Of In Defense Of Loose Translations: An Indian Life In An Academic World By Elizabeth Cook-Lynn, Kerri J. Malloy
Review Of In Defense Of Loose Translations: An Indian Life In An Academic World By Elizabeth Cook-Lynn, Kerri J. Malloy
Faculty Research, Scholarly, and Creative Activity
No abstract provided.
Regional Reprogramming And The Small Intestine: Analysis And Modeling Of Adaptive Regeneration Of The Epithelium, Sarah Elizabeth Waye
Regional Reprogramming And The Small Intestine: Analysis And Modeling Of Adaptive Regeneration Of The Epithelium, Sarah Elizabeth Waye
Arts & Sciences Graduate Student Theses and Dissertations
The small intestine in homeostasis is capable of regular regeneration, but in cases of massive injury like Short Bowel Syndrome, the innate human response often fails to fully compensate for the loss of nutrient absorptive surface area that accompanies bowel resection. Murine models display an active compensatory reaction deemed “adaptation” in which the surface area of the bowel is increased to accommodate nutrient absorptive needs. This observation has highlighted several gaps in knowledge regarding bowel adaptation. Firstly, what occurs on a molecular level in murine models during adaptation? Secondly, how can the findings in mice be applied to humans in …
Identification Of Multi-Tissue Protein Quantitative Trait Loci And Causal Inference Of Protein Effects In Neurological And Other Complex Human Diseases Via Mendelian Randomization, Chengran Yang
Arts & Sciences Graduate Student Theses and Dissertations
Alzheimer disease (AD) is the most common neurodegenerative disease, affecting 6.2 million people mostly aged 65 years or older in the United States as of early 2021. AD has been widely studied and characterized worldwide, but there is still no effective treatment or cure. Even the latest FDA-approved treatment, Aducanumab, cannot stop decline or improve cognition. To develop a truly effective treatments, researchers keep discovering genetic and molecular mechanisms underlying the disease. Protein biomarkers are keys to bridge the mechanisms to disease. Here, I first used a high-throughput proteomic dataset from three tissues (CSF, plasma, and brain) with array-based genotype …
Regulatory Effects Of The E. Coli Recbcd Nuclease Domain On Dna Unwinding Kinetics, Nicole Fazio
Regulatory Effects Of The E. Coli Recbcd Nuclease Domain On Dna Unwinding Kinetics, Nicole Fazio
Arts & Sciences Graduate Student Theses and Dissertations
I have examined the effects of deleting the nuclease domain of the E. coli helicase RecBCD on the rates of ATP-independent DNA melting, single stranded (ss) DNA translocation, and double stranded (ds) DNA unwinding by RecBCD. The canonical role of the nuclease domain is DNA degradation, but the removal of this domain showed unexpected effects on other RecBCD activities including DNA binding, melting, and unwinding. This thesis presents a mechanistic study of DNA unwinding by RecBCD and a RecBCD variant with the nuclease domain deleted (RecBΔnucCD). I examined the rates of ssDNA translocation and dsDNA unwinding by RecBCD and RecBΔnucCD …
The Role Of Neuronal Atp-Sensitive Potassium Channels In Learning And Memory, Shaul Vladimir Yahil
The Role Of Neuronal Atp-Sensitive Potassium Channels In Learning And Memory, Shaul Vladimir Yahil
Arts & Sciences Graduate Student Theses and Dissertations
ATP-sensitive potassium (KATP) channels link cellular metabolism and membrane excitability in many tissues, including brain and pancreas. Gain-of-function (GOF) mutations to KATP channels cause neonatal diabetes, with some patients exhibiting developmental delay, epilepsy, and neonatal diabetes (DEND) syndrome. Diabetic symptoms have been attributed to loss of membrane excitability and insulin secretion in pancreatic β-cells, though the origin of neurological deficits and the effects of neuronal KATP-GOF mutations more generally remain elusive. In this dissertation, I will present evidence that mice expressing KATP-GOF mutations pan-neuronally (nKATP-GOF) demonstrated sensorimotor and cognitive deficits, whereas hippocampus-specific hKATP-GOF mice exhibited predominantly learning and memory deficits. …
Weedy Rice As A Model System For The Study Of Microevolutionary Interactions In Agricultural Contexts, Marshall Jon Wedger
Weedy Rice As A Model System For The Study Of Microevolutionary Interactions In Agricultural Contexts, Marshall Jon Wedger
Arts & Sciences Graduate Student Theses and Dissertations
Just under one-half of the global population relies on cultivated rice (Oryza sativa) astheir primary source of calories, making the optimization of rice agriculture immensely important. One of the primary constraints to rice agriculture is the de-domesticated (feral) form of rice known as ‘weedy rice’ that aggressively competes for space, soil nutrients, and light. Heavy infestation can reduce crop yields by as much as 80%. As a closely-related weedy descendant of cultivated rice, chemical control is difficult in rice fields, and physical weeding is labor intensive, time consuming, and largely ineffective due to early life-stage mimicry of the crop. Weedy …
Genetic Risk Factors For Neurodevelopmental Disorders: Insights From Hipsc-Cerebral Organoids, Michelle L. Wegscheid
Genetic Risk Factors For Neurodevelopmental Disorders: Insights From Hipsc-Cerebral Organoids, Michelle L. Wegscheid
Arts & Sciences Graduate Student Theses and Dissertations
Neurofibromatosis type 1 (NF1) is a common neurodevelopmental disorder (NDD) characterized by remarkable phenotypic variability, where affected children manifest a spectrum of central nervous system (CNS) abnormalities, including brain tumors, impairments in attention, behavior, learning disabilities, and an increased incidence of autism spectrum disorder (ASD). A significant barrier to the implementation of precision medicine strategies for children with NF1 is a lack of prognostic risk factors to guide clinical management. However, emerging population-based genotype-phenotype association studies have suggested that the germline NF1 gene mutation may represent one clinically actionable risk factor for NF1-associated neurodevelopmental abnormalities. As a critical step in …
Pharmacotherapy For Non-Alcoholic Steatohepatitis - Current Status And Future Prospects, Ganesh Bhat
Pharmacotherapy For Non-Alcoholic Steatohepatitis - Current Status And Future Prospects, Ganesh Bhat
Manipal Journal of Medical Sciences
Non-alcoholic Steatohepatitis (NASH) is emerging as a leading cause of cirrhosis worldwide. Weight reduction through lifestyle modification is accepted first line treatment for these patients. Histological improvement in highrisk patient is the primary target of pharmacotherapy in NASH patients. Even though currently many drugs are available for these high-risk patients, none of them has been approved USA Food and Drug Administration (FDA) until now. Among these, vitamin E and pioglitazone has been approved by AASLD (American Association for the Study of Liver Diseases) in selected group of patients. There are more than a dozen drug targeting different pathways in NASH …
Malabar Pit Viper Envenomation Presenting With Symptomatic Hyperkalaemia In A Tertiary Care Centre In South Karnataka, Vrinda Lath
Malabar Pit Viper Envenomation Presenting With Symptomatic Hyperkalaemia In A Tertiary Care Centre In South Karnataka, Vrinda Lath
Manipal Journal of Medical Sciences
A 25-year-old male was bitten by a pit viper over the foot and presented with a tender and oedematous bitten limb a day after the bite. He had received anti-snake venom (ASV) at a local centre and developed anaphylaxis. He was admitted for observation and developed sudden onset hyperkalaemia and hemodynamic instability which responded to anti-hyperkalemic measures. We highlight envenomation by a species not known to cause any life-threatening complications, and emphasize the need for intensive monitoring and discuss the importance of species identification, knowledge of regional herpetofauna and treatment modalities including the need for a species-specific antivenin.
A Rare Case Of Chorioretinitis Sclopetaria- A Pellet In A Haystack, Yogish Kamath
A Rare Case Of Chorioretinitis Sclopetaria- A Pellet In A Haystack, Yogish Kamath
Manipal Journal of Medical Sciences
Chorioretinitis sclopetaria is a rare event with a poor visual prognosis, with less than a hundred cases reported worldwide. We report a case of an 8-year-old boy who presented with swelling and decreased vision in the left eye after an alleged fall. On examination, the affected eye showed periorbital ecchymosis, ptosis, subconjunctival haemorrhage, hyphema, and an afferent pupillary defect. A CT scan showed a foreign object lodged in the left orbit which was removed surgically. This case report intends to describe the rare occurrence of chorioretinitis sclopetaria in a child, wherein the history of gun pellet injury, elicited in retrospect, …
Human Plcg2 Haploinsufficiency Results In A Novel Immunodeficiency, Joshua Brandon Alinger
Human Plcg2 Haploinsufficiency Results In A Novel Immunodeficiency, Joshua Brandon Alinger
Arts & Sciences Graduate Student Theses and Dissertations
NK cells are critical for the recognition and lysis of herpesvirus-infected cells. Patients with NK cell immunodeficiency may suffer from unusually severe and/or recurrent herpesvirus infections; however, the genetic cause is frequently unknown. PLCG2 encodes a signaling protein in NK cell and B cell receptor signaling, in which dominant-negative or gain-of-function mutations may cause cold urticaria, antibody deficiency, or autoinflammation. However, loss-of-function mutations and PLCG2 haploinsufficiency have never been reported in human disease. We examined 2 families with autosomal dominant NK cell immunodeficiency with dual high-dimensional techniques, mass cytometry and whole-exome sequencing, to identify the cause of disease. We identified …
Slo2.1 Channels: A New Molecular Mechanism To Regulate Uterine Excitability, Juan Jose Ferreira
Slo2.1 Channels: A New Molecular Mechanism To Regulate Uterine Excitability, Juan Jose Ferreira
Arts & Sciences Graduate Student Theses and Dissertations
At the end of pregnancy, the uterus transitions from a non-contractile state to a highly contractile state. Two processes primarily drive this transition. First, from the 28th week of pregnancy until labor, the resting membrane potential of uterine (myometrial) smooth muscle cells (MSMCs) gradually becomes more positive (depolarizes) (Parkington et al. 1999). Second, at the end of pregnancy, MSMCs express more oxytocin receptors and become more sensitive to oxytocin (Kimura et al. 1996). However, the detailed mechanisms by which these processes occur have not been determined. My central hypothesis was that the Na+-activated K+ channel SLO2.1 plays a key role …
Developments In Proteomics, Trans-Splicing Technology And Endogenous Transcript Manipulation, Justin Alexander Melendez
Developments In Proteomics, Trans-Splicing Technology And Endogenous Transcript Manipulation, Justin Alexander Melendez
Arts & Sciences Graduate Student Theses and Dissertations
Technological innovation drives scientific discovery, unlocks new avenues of research, and allows us to ask questions in ways that were previously unavailable. With each technological advance, our ability to perturb and explore biological systems has grown in ways previously unimagined. The theme of my thesis is the development of new technologies in biology. To this end, I have worked on three technologies that contribute to the areas of protein sequencing, RNA barcoding for trans-splicing and single-cell applications, and a new method for transcriptional knockdown. In my first project, digital analysis of proteins by end sequencing (DAPES), we set out to …
Cyclodextrin-Based Supramolecular Drug-Delivery Nanomaterials And Shear-Thinning Hydrogels Using Ring-Opening Metathesis Polymerization, Ruihan Li
Arts & Sciences Graduate Student Theses and Dissertations
Cyclodextrins (CD) are a family of oligosaccharides that can non-covalently and precisely bind small hydrophobic drug molecules, such as antibiotics and anticancer drugs, through well-defined host-guest interactions inside the inner cavity of the macrocycle. Ring-opening metathesis polymerization (ROMP) is a versatile, functional group tolerant method of polymerization that is underexplored in biomedical applications relative to the more common controlled chain-growth polymerizations. In this dissertation, I describe my efforts to combine the supramolecular chemistry of CDs with that of ROMP using specialized functional monomers to synthesize several CD-based polymeric drug delivery nanomaterials. For example, in Chapter 2, a new type of …
La Esfera Lúdica: Entretenimiento Popular En El Espacio Público Urbano Del Río De La Plata, 1870-1933, Maria Soledad Mocchi Radichi
La Esfera Lúdica: Entretenimiento Popular En El Espacio Público Urbano Del Río De La Plata, 1870-1933, Maria Soledad Mocchi Radichi
Arts & Sciences Graduate Student Theses and Dissertations
In this dissertation, I focus on popular ludic and cultural practices that shaped the urban spaces of Uruguay and Argentina at the end of the nineteenth century and the beginning of the twentieth. I argue that by inhabiting the public sphere in close dialogue with modernization and urbanization, popular entertainment became a main protagonist within everyday life. Cultural practices such as carnival, theater, soccer, radio, and cinema, presented intersections between each other. These intersections generated what I term the ludic urban sphere, to underscore not just the overwhelming presence of play and entertainment as central elements in the urban landscape, …
The Effects Of Molecular Chaperone Modulation On Protein Folding, Prion Formation, And Prion Propagation In Saccharomyces Cerevisiae, Leeran Blythe Dublin Ryan
The Effects Of Molecular Chaperone Modulation On Protein Folding, Prion Formation, And Prion Propagation In Saccharomyces Cerevisiae, Leeran Blythe Dublin Ryan
Arts & Sciences Graduate Student Theses and Dissertations
Proper and efficient protein folding is vital for cell survival. Many factors affect protein folding fidelity and prion formation, including molecular chaperone availability and activity. Research has shown that modulating chaperone availability and function can affect protein misfolding and aggregation, as well as de novo prion formation and propagation. However, the factors involved and underlying mechanisms influencing prion formation and protein folding are largely unknown. The following work aims to elucidate these areas. The Nascent Polypeptide-Associated Complex (NAC) is the first point of chaperone contact for nascent polypeptides. Previous work has shown that disruption of the NAC leads to improved …
Material Difficulty And Individual Difference Factors Moderate The Eyewitness Confidence-Accuracy Relationship, Wenbo Lin
Arts & Sciences Graduate Student Theses and Dissertations
Recent studies have shown that eyewitness confidence is positively associated with high identification (ID) accuracy, but some eyewitness researchers have expressed concerns regarding the reliability of this confidence-accuracy relationship in applied settings (e.g., are there circumstances or moderator variables that make this relationship less reliable?). For the present study, we considered two types of moderator variables: material difficulty (i.e., the difficulty level associated with different sets of eyewitness stimuli) and individual difference factors such as face recognition ability. Experiment 1 examined whether these moderator variables significantly impair the confidence-accuracy relationship and Experiment 2 examined whether these same moderator variables equally …
Computational Methods For Analysis Of Data For Conformational And Phase Equilibria Of Disordered Proteins, Jared Michael M Lalmansingh
Computational Methods For Analysis Of Data For Conformational And Phase Equilibria Of Disordered Proteins, Jared Michael M Lalmansingh
Arts & Sciences Graduate Student Theses and Dissertations
Intrinsically disordered proteins and regions (IDPs / IDRs) are a class of proteins with diverse conformational heterogeneity that do not fold into a tertiary structure due to the lack of a native structural state. Consequently, disordered proteins are remarkably flexible and exhibit multivalent properties that enable them to adopt myriad functional roles within the cell such as: signaling transduction, transcription, enzymatic catalysis, translation, and many more. Due to their multivalency, some IDPs undergo monomeric and heterotypic interactions which can drive phase separation. Such IDPs can form membraneless organelles with specific regulatory roles within the cell which include, but are not …
Causal Function And Bias Correlation Of The Orbitofrontal Cortex In Economic Choices, Shi Weikang
Causal Function And Bias Correlation Of The Orbitofrontal Cortex In Economic Choices, Shi Weikang
Arts & Sciences Graduate Student Theses and Dissertations
Economic choices entail two mental processes, value calculation and value comparison (Niehans, 1990). Studies in the last twenty years have shown that neurons in the orbitofrontal cortex (OFC) could support both processes. Namely, in the studies in which monkeys chose between two juice options with various amounts, three functional cell groups had been found in the OFC: offer value cells encode the value of individual juices, chosen juice cells encode the choice in a binary way and chosen value cells encode the value of the chosen juice (Padoa-Schioppa and Assad, 2006). These results suggest a decision circuit within OFC with …
Paleo-Environmental Pollution Of The Bronze Production During The Shang Period At Anyang, Henan Province, China, Yi-Ling Lin
Paleo-Environmental Pollution Of The Bronze Production During The Shang Period At Anyang, Henan Province, China, Yi-Ling Lin
Arts & Sciences Graduate Student Theses and Dissertations
Paleo-environmental pollution is invested in both identifying anthropogenic activities and evaluating the environmental condition and its impact on humans to understand human-environment relationships and the human experience of the past. This project first investigates the environmental and health consequences of bronze production during the Shang period at Anyang. As a contribution to the growing scholarship in paleo-environmental and archaeological studies, this dissertation uses Shang bronze production in Anyang as a case study into how paleo- environmental pollution study can inform us about the on environmental and health conditions of lives in the Bronze Age China. Through geochemical analysis (ICP-MS, ICP-OES) …
Examining Individual Differences In Forgetting From Long-Term Memory, Christopher Lee Zerr
Examining Individual Differences In Forgetting From Long-Term Memory, Christopher Lee Zerr
Arts & Sciences Graduate Student Theses and Dissertations
Forgetting reflects the decreased likelihood of memory retrieval over time. With a few exceptions, although the mean likelihood of retrieval (or retention) across experimental conditions may differ markedly, rates of forgetting across those conditions do not differ. Similarly, although groups (e.g., young and old adults) may differ in the amount retained at a given point in time, the rates of forgetting tend not to differ across groups. In contrast, recent work suggests that individual differences in rates of forgetting may emerge when more sensitive statistical analyses are used on person-level performance. Some person-level variables purported to influence forgetting rate include …