Digital Commons Network^™

An Airtight Explanation Of "Hypoxia" Vs. "Hypoxemia", Sarah Bronson

Word for Word 2021

No abstract provided.

A Novel Approach For Microscale Dry Contact Stiction And Friction Assessment: Experimentation And Analysis, Bin Zhang, Reza Namakian, Xiaoman Zhang, W. J. Meng, Jennifer Hay, Kurt Johanns

Faculty Publications

Accurate and quantitative evaluation of friction is of fundamental interest for materials science and manufacturing. Driven by the trend towards miniaturization, micro metal forming techniques with characteristic forming dimensions approaching a few microns have developed rapidly over the past two decades. In contrast, the assessment of microscale friction is lagging. Here, we present a novel test, compression molding and demolding test (CMDT), to assess stiction and friction at the microscale. CMDT was conducted via in-situ instrumented molding and demolding of an Al specimen with cylindrical tool steel and Ti alloy punches. High-rate data acquisition enabled direct measurements, for the first …

Phase Stability Of Novel Hfnbtativzr Refractory High Entropy Alloy Under Ion Irradiation, Jianren Zhou, Mark Kirk, Pete Baldo, Shengmin Guo, Fengyuan Lu

Faculty Publications

HfNbTaTiVZr refractory high entropy alloy (RHEA) fabricated by arc melting shows the single-phase body-centered cubic (BCC) structure. Radiation-induced amorphization (RIA) is observed at 2 displacements per atom (dpa) at 298 K while the specimen remains its crystal structure at 423 K. The critical amorphization temperature (Tc) is likely within 298–423 K. RIA is mainly attributed to the accumulation of Frenkel pairs caused by elastic collisions under ion irradiation and the large atomic size mismatch in the studied RHEA facilitates the amorphization process. RIA of RHEA is for the first time reported and the finding challenges the current understanding of phase …

Current Complications In The Law On Myths And Stereotypes, Lisa Dufraimont

Articles & Book Chapters

Myths and stereotypes represent an ongoing problem in Canadian sexual assault trials. Often, and paradigmatically, defence lawyers and trial judges rely on discredited sexist assumptions to the prejudice of female sexual assault complainants. However, a review of the recent appellate case law reveals many cases that do not fit this paradigm. Complications that have arisen include stereotypes about men or accused persons, legitimate defence arguments misidentified as stereotypes, close cases where reasonable people disagree about whether stereotypes have been invoked, and prejudicial forms of reasoning based other axes of discrimination. This paper surveys these developments and assesses an attempt by …

Role Of Serum Amyloid A In Abdominal Aortic Aneurysm And Related Cardiovascular Diseases, Preetha Shridas, Avery C. Patrick, Lisa R. Tannock

Internal Medicine Faculty Publications

Epidemiological data positively correlate plasma serum amyloid A (SAA) levels with cardiovascular disease severity and mortality. Studies by several investigators have indicated a causal role for SAA in the development of atherosclerosis in animal models. Suppression of SAA attenuates the development of angiotensin II (AngII)-induced abdominal aortic aneurysm (AAA) formation in mice. Thus, SAA is not just a marker for cardiovascular disease (CVD) development, but it is a key player. However, to consider SAA as a therapeutic target for these diseases, the pathway leading to its involvement needs to be understood. This review provides a brief description of the pathobiological …

Getting It Right! Improving Kenya’S Human Capital By Reducing Stunting—A Household Account, Timothy Abuya, Wangari Ng'ang'a

Reproductive Health

In the last two decades, Kenya has attained middle-income status and established a diverse and private-sector-driven economy. On several socio-economic indicators, such as education, gender equality, and democracy, Kenya scores much higher than its peers. More than two-thirds of Kenyans are under 35 years of age, thus the country’s development hinges on the quality of its youth—their levels of education and skills, their values and attitudes, and the quality of their health and productivity. While Kenya’s investments in the development of its human capital positions the country well to sustain accelerated growth, the trajectory is threatened by high rates of …

Photobook: Getting It Right! Improving Kenya’S Human Capital By Reducing Stunting—A Household Account, Presidential Policy And Strategy Unit (Pasu), Sahihi Africa, Population Council Kenya

Reproductive Health

No abstract provided.

Study Of How Cancers Spread Promises Treatment Options, Shea Stewart

University of Mississippi News

American Cancer Society funds UM professor's breast cancer research

Informetrics Of Webinars Through Video Conferencing Platforms For Teaching And Learning By Different Lis Professional During Covid-19 Period: An Evaluative Study, Laltu Aich, Ankit Das

Library Philosophy and Practice (e-journal)

Now-a-days education and educational resources are open to all but we are facing a terrible epidemic situation due to Corona virus (COVID-19), so we need different electronic learning platforms for e-learning. In this present study, authors have explained, how many webinars are organized by Library and Information Science (LIS) professional during this period April 2020 to June 2021, distribution of webinars based on month capacity, how many web conferencing platforms used in LIS related webinars, distribution of types of organizers of webinars, distribution of webinars based on the respective region, distribution of webinars by time duration and time schedule. The …

Quantitative Characterization Of Microbial Ecologies In Dysbiosis And Infection, Eric Keen

Arts & Sciences Graduate Student Theses and Dissertations

In 1973, Theodosius Dobzhansky famously wrote that nothing in biology makes sense except in the light of evolution. Today, nearly 50 years later, little in microbiology – or in biology, for that matter – makes sense except in the light of genomics. Microbial genomics populates the field with innumerable testable hypotheses for evaluation in vitro and in vivo, allows us to monitor microbial populations in real time and at a massive scale, and underpins our approach to entire domains of microbiology, including microbial evolution. In this Thesis, I present three studies from my graduate research united by their common theme …

Surveillance And Dynamics Of Bacteria And Resistance Genes In Humans And Hospitals, Alaric Wences D'Souza

Arts & Sciences Graduate Student Theses and Dissertations

Bacteria live in, on, and around us. These bacteria affect human health through beneficial commensal interactions that promote normal development and through harmful infections or perturbations leading to disease. Understanding the prevalence, spread, and resilience of these bacteria in humans and human environments is critical to clinical medicine and epidemiology. I investigated environmental and human resident bacteria to understand dynamics in bacterial communities and how these dynamics may impact human health.Hospitals are one critical location of human-bacterial interactions. Bacteria can contaminate hospital surfaces from patients or environmental sources and subsequently transmit from surfaces to vulnerable patients. I analyzed bacteria from …

On The Challenges And Rewards Of Analyzing Molecular Dynamics At The Terabyte And Millisecond Scale, Justin Roy Porter

Arts & Sciences Graduate Student Theses and Dissertations

Molecular Dynamics (MD) and Markov state models (MSMs) are powerful tools for estimating and concisely representing the conformational ensemble accessible to biological macromolecules, particularly proteins. Conformational ensembles are of special importance biological function, both in health and disease, because biology derives from molecules’ entire conformational distribution rather than any single structure. Consequently, MD is poised to become a powerful tool for personalized medicine and for the study of molecular sequence-function relationships generally. However, because of their hyperdimensionality and size, just generating MD datasets and Markov state models (MSMs) that represent biologically relevant molecules is a substantive technical challenge. Then, even …

Influence Of Aging And Cerebrovascular Disease On Neuroimaging Measures Of Alzheimer Disease, Lauren Nicole Koenig

Arts & Sciences Graduate Student Theses and Dissertations

The overall goal of this dissertation is to gain a better understanding of how Alzheimer disease relates to normal aging and cerebrovascular disease to impact neuroimaging measures in a clinically meaningful way. Both aging and cerebrovascular disease are known to influence measures of Alzheimer disease, making it difficult to separate what changes are attributable specifically to Alzheimer disease. We hypothesize that a better understanding of these relationships will allow future studies to appropriately take these factors into account. In Chapters 2 and 3 we attempt to separate out the influences of normal aging and Alzheimer disease on measures of atrophy. …

Deconvolving Genomic Regulatory Heterogeneity With Self-Reporting Transposons, Arnav Moudgil

Arts & Sciences Graduate Student Theses and Dissertations

A cell’s identity is a function of the genes expressed in that cell, which are in turn regulated by transcription factors. Over the last decade, single-cell RNA sequencing (RNA-seq) has emerged as a powerful class of techniques to characterize cellular diversity in heterogeneous tissues. These methods barcode transcripts by their cell-of-origin and assign them to specific genes. The resulting high-dimensional data are further processed to reveal clusters of cells sharing transcriptional states. Annotating these clusters, based on either known or discovered marker genes, offers a glimpse into the dynamic composition of an organ or biological process. While single-cell RNA-seq excels …

Age-Dependent Search Behavior In The Colorado Checkered Whiptail (Aspidoscelis Neotesselatus), Carina Kusaka, Kaera Utsumi, Catherine Staley, Rachael Pedersen, Julia Valdivia, Elizabeth Liu, Hannah Caracalas, Hannah Reynolds, Maria A. Eifler, Douglas A. Eifler

Western North American Naturalist

We compared movement and space use patterns of foraging adult and juvenile Colorado checkered whiptails (Aspidoscelis neotesselatus) in pinyon pine–juniper woodland. Through focal observations, we characterized (1) movement paths as a series of step lengths and turn angles at 30-s intervals, and (2) habitat use reflected by the proportion of time spent in different vegetation types and in the open. Adults and juveniles differed in both movement and habitat use. Adults spent more time in the open and in association with mountain mahogany (Cercocarpus montanus), while juveniles were more frequently found in association with dead wood, …

Iron And Manganese Oxidation By Oxyhalogen Species: Implications For Paleoenvironmental Reconstruction On Mars, Kaushik Mitra

Arts & Sciences Graduate Student Theses and Dissertations

As the nearest planetary neighbor with potential earlier habitable conditions, Mars is replete with minerals that hold clues to its past chemistry and evolution of the aqueous systems. Oxidized iron (Fe) and manganese (Mn) minerals on Mars are geochemical markers of such environments in which they formed and record past pH, redox conditions, and intensity of water-rock interaction. Fe and Mn oxides can therefore be used to reconstruct past Martian environmental conditions from settings where aqueous fluids were active. Various processes that form Fe and Mn oxide minerals on Mars have been previously proposed, including chemical oxidation using molecular oxygen …

Mass Spectrometry-Based Protein Footprinting: High-Throughput Maldi Platform And Large Protein Complexes Of Baf, Ruidong Jiang

Arts & Sciences Graduate Student Theses and Dissertations

Human’s advances in understanding biological processes rely heavily on the breakthroughs in biophysical tools. Mass spectrometry (MS)-based protein footprinting, which interrogates protein structures by measuring protein solvent assessable surface area (SASA), has grown rapidly in the last decade, successful in providing valuable data for numerous protein systems. This thesis focuses mainly on this technology.We set out to push the boundary of MS-based protein footprinting further into the new areas, preparing it for potential future applications including large-scale experiments that require high-throughput analysis the structure of large, complicated protein complexes. This thesis devotes five chapters to the method development of MS-based …

License To Heal: Understanding A Healthcare Platform Organization As A Multi-Level Surveillant Assemblage, Handan Vicdan, Mar Pérezts, Asım Fuat Fırat

Management Faculty Publications

Platform organizations bring renewed attention to power disparities and risks in the rise of surveillance capitalism. However; such critical accounts provide a partial understanding of the complexity of surveillance phenomena in such shifting socio-technical and digital environments.The findings from a netnographic investigation of a healthcare platform organization, PatientsLikeMe, unravel how platforms become the locus where multi-level flows of surveillance converge, thereby constituting what we identify as a surveillant assemblage. We develop a comprehensive approach for understanding how platforms constitute a dynamic crossroads of micro-, meso- and macro-surveillance phenomena within and beyond the online communities they create.This study highlights this surveillant …

Defining The Epigenetic And Transcriptional Regulatory Mechanisms By Which Hrsv Ns1 Alters Host Transcriptional Response, Nina Rose Beri

Arts & Sciences Graduate Student Theses and Dissertations

No abstract provided.

Greta Thunberg: A Small But Mighty Voice For The Environment, Madilyn Mortelliti

Faculty Curated Undergraduate Works

Abstract

This research paper discusses Greta Thunberg and the impact she has as a climate change activist. Thunberg faces many challenges as a young woman, but overcomes these difficulties while encouraging others to follow in her footsteps. She presents herself as a positive role model for younger generations. Thunberg has many accomplishments as an extremely young woman that leads to her global iconicity. She makes her power known in front of the highest ranked men in the world which forces legislation to make a change. Thunberg motivates others to make a difference before all hope is lost.

Inequalities In Heterosexual Sex And How We Can Become Equals, Sophie Bierly

Undergraduate Honors Theses

Sexual inequality is well researched in the academic sphere but is absent from the political realm. Previous research has identified that sex is defined for men’s pleasure, that women suffer from an orgasm gap, and that male domination is standard in heterosexual sex. Due to the private nature of sex, sexual inequality is untouched as a personal problem rather than deconstructed as a political injustice. However, the universality of sexual inequality in heterosexual relationships demonstrates that these overlooked personal problems are rooted in widespread cultural misogyny. Sex is one of the primary ways in which we perform gendered socialization, due …

Modifying The Aspect Survey To Support The Validity Of Student Perception Data From Different Active Learning Environments, Nicole Naibert, Erin E. Shortlidge, Jack Barbera

Chemistry Faculty Publications and Presentations

Measuring students’ perceptions of active learning activities may provide valuable insight into their engagement and subsequent performance outcomes. A recently published measure, the Assessing Student Engagement in Class Tool (ASPECT), was developed to assess student perceptions of various active learning environments. As such, we sought to use this measure in our courses to assess the students’ perceptions of different active learning environments. Initial results analyzed with confirmatory factor analysis (CFA) indicated that the ASPECT did not function as expected in our active learning environments. Therefore, before administration within an introductory biology course that incorporated two types of active learning strategies, …

Neural Mediators Of Subjective And Autonomic Responding During Threat Learning And Regulation, Hannah S. Savage, Christopher G. Davey, Tor D. Wager, Sarah N. Garfinkel, Bradford A. Moffat, Rebecca D. Glarin, Ben J. Harrison

Dartmouth Scholarship

Threat learning elicits robust changes across multiple affective domains, including changes in autonomic indices and subjective reports of fear and anxiety. It has been argued that the underlying causes of such changes may be dissociable at a neural level, but there is currently limited evidence to support this notion. To address this, we examined the neural mediators of trial-by-trial skin conductance responses (SCR), and subjective reports of anxious arousal and valence in participants (n = 27; 17 females) performing a threat reversal task during ultra-high field functional magnetic resonance imaging. This allowed us to identify brain mediators during initial threat …

Working Paper No. 57, The Plight Of The Indigenous In British North America, Maria Nicolas-Reyes

Working Papers in Economics

This inquiry seeks to establish that the Indigenous population of North America experienced a tragic fate as a result of British colonization and American dominance. Upon the arrival of the English colonists, infectious diseases spread rapidly, disrupting Native American’s way of life and also decimating their populations. This inquiry examines two geographic areas—Virginia’s Eastern Shore and the Midcontinent—in order to demonstrate how these diseases affected Native Americans differently. Aside from the negative effects of the introduction of new infectious diseases, Indigenous peoples endured genocide perpetrated by English settlers as a means to gain greater control of their lands. Lastly, Indigenous …

Virology: Mutagenizing The Proteolytic Cleavage Site In The Major Capsid Protein In Ssv1, Thejanee Liyanaarachchi

University Honors Theses

SSV1, spindle-shaped virus 1, is an archaeal virus with a unique shape that belongs to the family of fuselloviruses and infects hyperthermophilic archaea that thrive at 80°C and pH 3. SSV1 has two capsid proteins, VP1 and VP3, that presumably produce the lemon-shaped virion structure characteristic of fuselloviruses. The VP1 amino acid sequence is highly conserved among SSVs. Here, we investigate the importance of the proteolytic cleavage site in position E66 in VP1 by changing its glutamic acid to the other 19 amino acids. We have developed a new protocol for creating SSV1 mutants through HiFi Assembly (NEB) to increase …

An Investigation Into The Relationship Between Obstetric Racism And Postpartum Depression In Black Women, Miguel A. Claxton Iii

University Honors Theses

Postpartum depression is the most common postpartum mood disorder, with 13% of new mothers reporting symptoms within the first year. Adverse birth outcomes, such as low birth weight and preterm birth co-index with the development of postpartum depression. This correlation is particularly alarming considering that Black women have about a 60% higher rate of preterm birth and an 88% higher rate of low birth weight infants than Caucasian women. By utilizing theories of stratified reproduction, necropolitics, and obstetric racism, this paper aims to situate postpartum depression in Black women as a psychological response to systems of medicolegal control and domination. …

A Rapid Screening Method For Ecological Risks Posed By Different Land Use Intensities: Case Study Of Marikina City’S River System, Maria Aileen Leah Guzman, Charlotte Kendra Gotangco Gonzales, Rene Juna Claveria, Philippe Joshua Evardo, Jean Jardeleza Mijares

Journal of Management for Global Sustainability

Land use plays an important role in environmental and sustainability research because of its potential contribution to ecosystem protection or degradation. However, most risk maps used in comprehensive land use planning only identify areas at risk, for example, to various geophysical or climate- and weather-related hazards. It would also be useful to identify land areas that pose a risk to ecological systems. In this study, a simplified method adapted from the source-habitat approach and the relative risk model was used to explore the potential ecological risk of exposure to water pollutants posed by land uses on the river system in …

Acceptance, Confidence, And Time: Exploring Dynamics Of Middle And Secondary Science Teacher Autonomy In Teaching Evolution In The Southeastern United States, Amanda L. Townley

Middle Grades & Secondary Education: Faculty Publications

Evolution education represents the greatest challenge to scientific literacy in the United States. Long accepted as the foundational concept of biology, in the public realm evolution elicits controversy. The Southeastern United States is a breeding ground for this, and other, anti-science thinking that has far-reaching implications as seen during the 2020 pandemic and antiscience legislation from the region. One approach to close gaps in understanding evolution is to ensure that it is taught in schools in a way that is robust and accurate, as teachers are the front lines in the fight for scientific literacy. For that to happen, teachers …

Antibody-Drug Conjugates Plus Janus Kinase Inhibitors Enable Mhc-Mismatched Allogeneic Hematopoietic Stem Cell Transplantation, Stephen P Persaud, Julie K Ritchey, Sena Kim, Sora Lim, Peter G Ruminski, Matthew L Cooper, Michael P Rettig, Jaebok Choi, John F Dipersio

Open Access Publications

Despite the curative potential of hematopoietic stem cell transplantation (HSCT), conditioning-associated toxicities preclude broader clinical application. Antibody-drug conjugates (ADCs) provide an attractive approach to HSCT conditioning that minimizes toxicity while retaining efficacy. Initial studies of ADC conditioning have largely focused on syngeneic HSCT. However, to treat acute leukemias or induce tolerance for solid organ transplantation, this approach must be expanded to allogeneic HSCT (allo-HSCT). Using murine allo-HSCT models, we show that pharmacologic Janus kinase 1/2 (JAK1/2) inhibition combined with CD45- or cKit-targeted ADCs enables robust multilineage alloengraftment. Strikingly, myeloid lineage donor chimerism exceeding 99% was achievable in fully MHC-mismatched HSCT …

Utility Of Facebook's Social Connectedness Index In Modeling Covid-19 Spread: Exponential Random Graph Modeling Study, Beth Prusaczyk, Kathryn Pietka, Joshua M Landman, Douglas A Luke

Open Access Publications

BACKGROUND: The COVID-19 (the disease caused by the SARS-CoV-2 virus) pandemic has underscored the need for additional data, tools, and methods that can be used to combat emerging and existing public health concerns. Since March 2020, there has been substantial interest in using social media data to both understand and intervene in the pandemic. Researchers from many disciplines have recently found a relationship between COVID-19 and a new data set from Facebook called the Social Connectedness Index (SCI).

OBJECTIVE: Building off this work, we seek to use the SCI to examine how social similarity of Missouri counties could explain similarities …