Digital Commons Network^™

De Novo Molecular Design With Agentic Ai: Integrating Tree Search And Iterative Refinement, Yukhe Lavinia, Dony Ang, Hagop S. Atamian

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Agentic AI frameworks that couple language model generation with iterative tool feedback offer a promising paradigm for automating complex molecular design tasks, yet systematic comparisons of agentic design patterns, such as exploration-focused, refinement-focused, and hybrid, remain scarce. Here, we evaluate three such strategies applied to structure-based de novo molecular design. Language Agent Tree Search (LATS) frames generation as Monte Carlo Tree Search-guided exploration of chemical space. A Reflexion-inspired Self-Improvement (SI) loop critiques and revises candidates using cheminformatics filters and docking feedback. A Hybrid strategy uses LATS to generate diverse, high-quality seeds, which are then refined with SI. We benchmark these …

Gender Is Critical To Understanding How Egalitarianism Works, Ivan Tacey, Camilla Power, Jerome Lewis, Ian Watts, Chris Knight, Morna Finnegan

School of Law, Humanities and Social Sciences

The plural processes underlying egalitarianism should be gendered adequately, with women seen as drivers and innovators from an evolutionary perspective. We apply this across all six processes enumerated by Stibbard Hawkes & von Rueden and advocate ritual as a seventh core process, the engine of reverse dominance.

Keith Lamonte Lovett

African American Funeral Programs

No abstract provided.

October 2, 2026 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Bridging Fet And He: A Case Study In Cross-Institutional Programme Co-Design, Muireann Okeeffe, Kevin Hora

Irish Journal of Academic Practice

The purpose of this paper is an exploration of curriculum design in a collaborative cross-sectoral context. In Ireland, new national policy has presented an opportunity to widen participation from Further Education and Training (FET) into university degree programmes. This is a case study of this National Tertiary Office (NTO) initiative providing a seamless pathway into university education. The BA (Honours) in Politics, Society and Media completed in collaboration with three FET colleges is the first NTO model programme for Technological University Dublin.  This analysis is shaped drawing on insider knowledge and documentation generated throughout the design and development process. It …

Metanet: A Supervised Ensemble Learning Framework For Reconstructing Direct And Functional Tissue-Specific Transcription Factor Networks, Wooseok J Jung, Sandeep Acharya, Daniel P Ruskin, Shu Liao, Vaha Akbary Moghaddam, Zolboo Erdenebaatar, Michael R Brent

2020-Current year OA Pubs

MOTIVATION: Reconstructing tissue-specific transcription factor (TF) networks remains challenging. TF-motif-based methods often lack functional validation, while expression-based methods struggle to distinguish direct binding from indirect regulation. Integration of diverse data types is necessary to accurately prioritize likely functional targets directly bound by TFs across human tissues.

RESULTS: We introduce METANet (Motif Expression TF Association Networks), a supervised ensemble learning framework that combines TF motifs, cis-regulatory element activity, and linear and nonlinear expression-derived features to predict TF binding. Applied to 36 human tissues, predicted METANet maps significantly outperform established methods in identifying direct, likely functional targets of TFs validated by ChIP-seq …

Sortscore: Sort-Seq Mave Scoring And Visualization Using Python, Caitlyn Chitwood, Emily Orr, Dustin Baldridge

2020-Current year OA Pubs

SUMMARY: A growing number of tools enable the analysis of large variant libraries produced by multiplexed assays of variant effects (MAVEs). Experiments using fluorescent reporters and fluorescence-activated cell sorting sequencing (FACS-seq or Sort-seq) can coarsely quantify a given variant's impact on phenotypes such as transcription activity. Existing bioinformatics tools for Sort-seq data broadly fall into two categories: methods that model a genotype-phenotype landscape to infer latent variant phenotypes, and methods that directly estimate individual variant scores from experimental binned counts. Within this second category, sortscore provides an activity score computed directly from observed counts without fitting a model, retaining the …

Perspectives On Person‐Centred End‐Of‐Life Care In Care Homes: Findings From A Qualitative Secondary Analysis, Gary Hodge, Susie Pearce

School of Nursing and Midwifery

Background: The number of older people dying in long-term care facilities (LTCF) is growing globally. This highlights an urgent need for high-quality and person-centred palliative and end-of-life care (PEoLC) to be incorporated in LTCFs’, such as care homes. Resident health and care complexities can lead to challenges around PEoLC decision-making and delays in pre-death discussions, ultimately impacting on a care home’s ability to provide a ‘good death’ for the resident and those caring for them. Aim: We aimed to explore what good person-centred end-of-life care might look like in a care home from the perspective of residents, family members and …

Impact Of Employment Status And Housing Stability On Tuberculosis Treatment Adherence In Virginia, Samuel Deapeh Worgee

Walden Dissertations and Doctoral Studies

Tuberculosis (TB) cases have resurged in Virginia, yet the structural determinants shaping treatment completion among socioeconomically marginalized populations remain unquantified locally, leaving public health programs without state-specific predictive evidence. Grounded in the World Health Organization's social determinants of health framework, this quantitative, ex post facto study examined how employment status, housing stability, and social risk factors predicted TB treatment completion. De-identified surveillance records for N = 898 adult TB cases reported from 2020 through 2024 were extracted from the Virginia Electronic Disease Surveillance System and analyzed using a multivariable binary logistic regression, controlling for age, sex, race/ethnicity, and radiographic severity …

Mental Well-Being Of Parents Who Have A Child With A Disability, Miracle Denae Adkins

Walden Dissertations and Doctoral Studies

Parents of children with developmental disabilities often experience elevated levels of stress and emotional burden associated with caregiving responsibilities, which can affect their mental health and overall well-being. The purpose of this generic qualitative study was to explore the perceptions, experiences, and decision-making processes of parents of children with developmental disabilities regarding the use of resources to support their own mental health. Data were collected through semistructured interviews, and data were analyzed using thematic analysis. The findings revealed that parents’ decisions to seek and use mental health resources were influenced by multiple factors, including accessibility and availability of services, financial …

Implementation Of A Standardized Social Determinants Of Health Screening And Documentation Workflow In Primary Care, Callistus Eze Okereh

Walden Dissertations and Doctoral Studies

The completed quality-improvement project addressed inconsistent screening and incomplete electronic health record (EHR) documentation of low-income, limited family support, and transportation barriers in a primary care clinic. The nursing practice problem can disrupt access, adherence, chronic disease management, and continuity of care. The practice-focused question examined whether an ADDIE-based education program would improve social determinants of health (SDOH) screening, EHR documentation, staff knowledge and confidence, and referral or follow-up documentation during a 6- to 8-week period. The project purpose was to develop, implement, and evaluate a role-based education program and standardized workflow for clinic staff. Evidence sources were drawn from …

Educators’ Perceptions Of The Challenges Of Reintegrating High School Students Returning From Suspension In A Western Suburban School District In Chicago, Rebecca Moss

Walden Dissertations and Doctoral Studies

The problem that was addressed through this study was that Grade 9–12 educators face challenges in implementing effective behavioral support systems for students returning to school after a suspension. Grounded in Bandura’s social cognitive theory, the purpose of this basic qualitative study was to investigate Grade 9–12 educators’ perceptions of the challenges they face and their recommendations when supporting students who return to school after a suspension in a western suburban Chicago district. Semistructured interviews were conducted with 11 purposely sampled Grade 9–12 educators including administrators, teachers, social workers, school counselors, and school psychologists. Through thematic analysis, four themes emerged. …

Exact Formulas For Restricted Coprime Representations Of Even Integers, Andres Mauricio Salazar

Communications on Number Theory and Combinatorial Theory

Let p ≥ 5 be prime, and let g(2n,p) denote the number of unordered representations by positive integers 2n = h + k, with h ≤ k and gcd(h,6p) = gcd(k,6p) = 1. Every positive integer coprime to 6 belongs to exactly one of the families 6z + 1 and 6z + 5. In each family, divisibility by p excludes one explicit residue class of z modulo p. We use these two excluded classes to derive an exact formula for g(2n,p) from finite residue counts and nonnegative lift counts. The formula is valid for every positive integer n, including all …

Women Leaders In Higher Education Amidst Crisis: A Narrative Inquiry Exploring Ethical Decision-Making, Jacqueline Hawkins

Doctor of Education Program Dissertations

Women leaders in higher education navigate complex institutional environments in which ethical decisions are made under conditions of uncertainty, urgency, and competing responsibilities (Gigliotti, 2020; Riggio & Newstead, 2023). The problem addressed in this study was to explore how women leaders navigated ethical complexities, balanced competing responsibilities, and made meaning of crisis leadership experiences within higher education contexts. The purpose of this qualitative narrative inquiry was to explore how women leaders in higher education describe their experiences with ethical decision-making during crisis situations. Guided by the ethic of care described by Noddings (1984, 2013), the study examined participants’ ethical reasoning, …

Nature And The Fulfillment Of Psychological Needs: A Qualitative Study, Leah Skelton

The Bear Counseling Collective

As mental health disorder rates increase and nature contact decreases in the general population, it is in the interest of public health to understand the impact of nature on mental health and social belonging, particularly in order to utilize these benefits most effectively and efficiently for intervention design. Estimates of mental health disorder prevalence indicate one in five adults is affected annually (CDC, 2023; NIMH, 2023), with rates of anxiety, depression, and psychological distress rising in particular among youth and young adults (CDC, 2023). Similarly, as rates of stress and loneliness increase, researchers and public health organizations alike are calling …

Counselors-In-Training Attitudes Towards Social Justice Oriented Self-Disclosure, Kaitlyn Jones

The Bear Counseling Collective

The purpose of this phenomenological study will be to understand the attitudes towards social justice-oriented self-disclosure in counselors-in-training participating in their first practicum experience. By exploring their lived experiences and perceptions, this study seeks to illuminate how counselors-in-training (CITs) navigate the tension between clinical neutrality and social justice oriented engagement in therapeutic spaces.

Preparing For Effective Supervision: Considerations For First Time Supervisees, Mallory Radcliff, Laura Rivas

The Bear Counseling Collective

Supervision is an essential part of clinical training and serves as an essential support to students who are beginning to see clients for the first time (American Counseling Association [ACA], 2014; Council for Accreditation of Counseling and Related Educational Programs [CACREP], 2024). To effectively utilize supervision, it is important to establish shared expectations and goals between supervisor and supervisee (Bernard & Goodyear, 2019). Without previous experience in supervision, it may feel challenging for first time supervisees to know what appropriate goals or expectations of supervision are. Current literature focuses primarily on effective supervision from a supervisory perspective and lacks a …

Mitigating Mental Health Disparities: Ethnic Matching As A Moderating Variable On Help Seeking Using The Theory Of Planned Behavior, Max Oishi

The Bear Counseling Collective

There are significant mental health treatment disparities for racially and ethnically minoritized (REM) populations (Lin et al., 2023; McGuire & Miranda, 2008; Thomeer et al., 2023). These disparities include REM populations seeking help for mental health treatment at differing rates compared to European Americans along with significant treatment underutilization for REM populations along with intergroup differences (Choi et al., 2019; Hosseini & Kubavat, 2022; Kim & Lee, 2022; Kwong et al., 2025; Schraufnagel et al., 2006; Sheehan et al., 2018 & 2024). Due to underutilization, research suggests ethnic matching and/or racial matching could mediate mental health disparities for REM populations …

Volume 3 (2026), The Bear Counseling Collective

The Bear Counseling Collective

A journal of student counselors' reflections on culturally attentive mental health care and advocacy.

Muharremi, Robert, And Alisa Ramadani. Transforming A Guerrilla Into A Regular Army: From The Kosovo Liberation Army To The Army Of The Republic Of Kosovo. Cham: Palgrave Macmillan, 2024., Besa Kabashi Ramaj

Journal of Peace, Conflict, and Security Studies

Robert Muharremi and Alisa Ramadani’s Transforming a Guerrilla into a Regular Army: From the Kosovo Liberation Army to the Army of the Republic of Kosovo seeks to provide an accessible, academic narrative of Kosovo’s security transformation. It traces the evolution from the Kosovo Liberation Army (KLA), through the Kosovo Protection Corps (KPC), to the current Kosovo Security Force (KSF). The result of this evolution is a military force which today holds a full-fledged defense mission.

Visoka, Gëzim. The Derecognition Of States. Ann Arbor: University Of Michigan Press, 2024., Aidan Hehir

Journal of Peace, Conflict, and Security Studies

Gëzim Visoka describes the derecognition of states as “a puzzling feature in world politics” (p. 114). This is certainly true. For many decades derecognition was a peripheral concern given it was rarely practiced after the UN was established in 1945; one notable exception being the derecognition of Taiwan, which has been ongoing since the 1950s. In recent years, however, it has become of significantly greater interest as it has become more common; of the five cases Visoka examines – Taiwan, Western Sahara, Abkhazia, South Ossetia, and Kosovo – four are very definitely products of the post-Cold War era. Despite this, …

Hehir, Aidan. Kosovo And The “Internationals”: Hope, Hubris, And The End Of History. Cham: Palgrave Macmillan, 2024, Sead Zimeri

Journal of Peace, Conflict, and Security Studies

Hope is enjoying a scholarly renaissance. Building on the “standard account” of hope as a desire for an outcome believed to be possible, recent work by Luc Bovens, Victoria McGeer, Adrienne Martin, Darrel Moellendorf, Michael Milona, and Katie Stockdale has refined the concept, distinguishing it from optimism and expectation, and asking when hoping is rational and what it requires. Yet this literature has remained largely within moral psychology; sustained tests against concrete political history are rare. Conversely, the enormous literature on humanitarian intervention and state-building has had much to say about power, legitimacy, and paternalism, and almost nothing about hope. …

Identité Ambiguë, Mémoire Traumatisée, Et Discours Postcolonial Dans Petit Pays De Gaël Faye, Israel Adégòkè Owóṣení

Tête à Tête: Journal of Francophone Studies

Les écrits autofictifs et semi-autobiographiques de la littérature postcoloniale francophone sont encore à explorer et à discourir, surtout dans le contexte littéraire du XXIe siècle où apparaissent des motifs récurrents et nouveaux tels que l’ambiguïté culturelle, l’hybridité, l’altérité, l’inclusion, la liminalité, le traumatisme et l’effet négatif souillé du postcolonialisme à la mémoire dans une nouvelle ère. Ainsi, cette étude est conçue pour examiner l’ambiguïté identitaire de Gaby et les legs de la colonisation émanant des conflits intertribaux, de la guerre, du génocide et de la violence, qui ont largement miné la perception psychologique du héros - Gaby.

Cette étude a …

La Traduction Se Mondialise Au Sein Des Organisations Internationales : Une Bénédiction Ou Une Malédiction?, Ezekiel O. Tanitolorun Ph.D, Tajudeen Salaudeen

Tête à Tête: Journal of Francophone Studies

Résumé

Nul n’ignore le fait que le monde devient de plus en plus un petit village à travers l’utilisation de la traduction pour que les hommes se comprennent facilement dans toutes les activités quotidiennes. Le concept de mondialisation s’explique comme l’expansion et l’harmonisation des liens d’interdépendance entre les nations, les activités humaines et les systèmes politiques à l’échelle du monde. Elle désigne un processus économique et politique qui a le but de rassembler des économies, des cultures et des sociétés en un monde. Cette communication vise à explorer l’efficacité de la traduction au sein des organisations internationales comme la Communauté …

Beyond Words: Semiotic Decoding Of Rẹ́Rẹ́Rún (Catastrophe Au Rendez-Vous) By Ọládẹ̀Jọ Òkédìjí And The Rich Tradition Of Yorùbá Theater, Nafiu O. Oloore Mr

Tête à Tête: Journal of Francophone Studies

Many researchers have focused on analysing novels, poems, and drama in the French language while neglecting certain subgenres. Although numerous studies have been conducted on semiotic analysis in French, little effort has been made to analyze Yorùbá drama. Thus, this study aims to provide a semiotic analysis of Rẹ́rẹ́rún (Catastrophe au rendez-vous) by Ọládẹ̀jọ Òkédìjí. This study adopts a qualitative research approach and textual explanation as its methodology. The semiotics theory proposed by Ferdinand de Saussure is employed as the theoretical framework. Following the qualitative method, twenty signs relevant to this study were selected for interpretation. Semiotics is chosen because …

L’Éducation, Un Chemin Inévitable De L’Altérité À L’Inclusion; Un Récit De La Femme Africaine Dans Aya De Yopougon(1-3) De Marguerite Abouet Et Clément Oubrerie, Nkonye Lolita Nmorka

Tête à Tête: Journal of Francophone Studies

Le patriarcat en Afrique, ancré dans la domination masculine et la subjugation féminine, joue un rôle intellectuel depuis quelque temps. Cependant, la phase des mécontentements au sujet de la marginalisation des femmes s’efface progressivement, vu que le discours féminin s’oriente vers une revalorisation visant une inclusion constructive pour l’évolution meilleure de la société. Cette étude se concentre sur l’éducation des filles comme un déclencheur puissant pour le changement de paradigme nécessaire, passant de la relégation et de l’altérité à des réalisations monumentales et des représentations sociales remarquables qui offrent à la femme les connexions nécessaires pour s’épanouir. En appliquant la …

Les Voix Féminines Contre La Domination Patriarcale : Analyse De Rebelle De Fatou Keïta Et Modukpè, Le Rêve Brisé D’Adélaïde Fassinou, Ganiyat Omotola Adeniran

Tête à Tête: Journal of Francophone Studies

La littérature africaine contemporaine constitue un espace privilégié pour l’expression des voix féminines longtemps marginalisées dans un contexte dominé par le patriarcat et les traditions contraignantes. Le présent article propose une étude des romans Rebelle (1998) de Fatou Keïta et Modukpè, le rêve brisé (2000) d’Adélaïde Fassinou. Ces deux récits mettent en lumière les mécanismes d’assujettissement des femmes africaines à travers des pratiques comme l’excision, le mariage forcé, la résignation sociale et les interdits religieux. En mobilisant une approche féministe africaine, l’analyse montre que les héroïnes Malimouna et Modukpè incarnent deux trajectoires contrastées : la révolte et la quête d’autonomie …

Une Analyse Intersectionnelle De L'Albinisme Dans L'Instinct De Survie D'Éveline Mankou Et Ses Implications Contemporaines, Gracious Ojiebun, Eiloghosa Enogiomwan

Tête à Tête: Journal of Francophone Studies

Grâce à l'inclusion numérique, l'éducation devient plus interactive, accessible et inclusive, néanmoins, les enfants atteints d'albinisme en sont souvent exclus en raison de préjugés socio-culturels, de l'écart numérique et des barrières sociales systémiques. L'article explore comment les liens entre la culture, la géographie, la religion, le genre et le statut socio-économique peuvent conduire à une marginalisation violente en se servant d'une évaluation critique de L'instinct de survivre d'Evline Mankou, et en utilisant la théorie de l'intersectionnalité de Crenshaw, 1989.

Le roman dépeint un monde où la superstition et les traditions patriarcales condamnent un enfant atteint d'albinisme, tout en offrant un …

Voix Proverbiales Et L'Esthétique Socioculturelle : Les Proverbes Africains Dans La Trilogie De Kouta De Massa Makan Diabate, Ademola Malick Adebayo, Israel Adégòkè Owóṣení

Tête à Tête: Journal of Francophone Studies

Dans les traditions orales africaines, les proverbes sont des paroles condensées de sagesse, mot d'esprit, de raisonnement social et d'esthétique culturelle. La véritable littérature africaine est l’oralité et elle démontre la richesse linguistique, la complexité culturelle et l’esthétique de la parole à travers les proverbes, les chansons, les épopées, les mythes et les légendes ainsi de suite. L’oralité reflète la richesse linguistique et l’identité culturelle du continent noir. Cependant, les proverbes sont des transporteurs particuliers de la sagesse, la morale, la valeur, les codes sociaux et la croyance d’une société donnée. Dans la trilogie de Massa Makan Diabaté, les proverbes …

L’Insécurité Linguistique Selon La Perspective Des Élèves D’Immersion Française En Saskatchewan, Olushola Adedeji, Michael Akinpelu

Tête à Tête: Journal of Francophone Studies

Cet article examine l’insécurité linguistique (IL) chez des élèves d’immersion française (IF) en Saskatchewan en s’appuyant sur la sociolinguistique pour le changement. À partir d’un devis mixte (un questionnaire à large échelle auprès d’élèves de 7e–12e année et des groupes de discussion focalisés avec des élèves de 11e–12e année), l’étude décrit les différentes manifestations de l’IL, ses causes et ses effets sur les élèves tout en recensant des stratégies d’adaptation. Les résultats de l’étude montrent que l’IL est moins liée à une compétence linguistique objective qu’à des conditions sociales et pédagogiques modifiables. Des recommandations concrètes sont proposées, notamment la légitimation …