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Information Literacy For Global Inclusion: Designing An Annotated Bibliography For Global Search And Selection, Pamela A. Espinosa De Los Monteros, Elizabeth L. Black Dec 2021

Information Literacy For Global Inclusion: Designing An Annotated Bibliography For Global Search And Selection, Pamela A. Espinosa De Los Monteros, Elizabeth L. Black

Communications in Information Literacy

The COVID-19 pandemic has reinforced the notion that our world is global and interdependent. Despite the ever-increasing connection of global with local, there continues to be formidable barriers in accessing information produced in different international contexts and languages. This Innovative Practices article details the redesign of an annotated bibliography assignment in an international studies course to support the inclusion of global perspectives into the information practices of undergraduate students. The redesign embedded explicit information literacy dispositions and global citizenship education competencies through the search and selection of global information sources. The authors discuss the instructional elements used, student outcomes, and …

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Remote Reference Consultations Are Here To Stay, Emily Reed Dec 2021

Remote Reference Consultations Are Here To Stay, Emily Reed

Communications in Information Literacy

Remote reference consultations have considerably increased due to the need to provide remote services during the COVID-19 pandemic. Conducting reference consultations via videoconferencing not only offers many benefits to student researchers it also presents an opportunity for librarians to embrace a learner-centered teaching mindset when approaching remote consultations by developing consultation learning goals in alignment with the Framework for Information Literacy for Higher Education. Designing consultations to be learner-centered yields benefits for students such as the student actively practicing their own searches as well as more thorough source evaluation. Additionally, videoconferencing technology allows for a more seamless information sharing …

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A Perfect Meal, Stewart Brower Dec 2021

A Perfect Meal, Stewart Brower

Communications in Information Literacy

No abstract provided.

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Beam Me Up: Teaching Rhetorical Methods For Source Use And Synthesis, Ashley Roach-Freiman Dec 2021

Beam Me Up: Teaching Rhetorical Methods For Source Use And Synthesis, Ashley Roach-Freiman

Communications in Information Literacy

BEAM is a schema for categorizing the rhetorical positions of authors according to the author’s intention or purpose of the information. The author critiques common methods of teaching source evaluation and proposes that instruction librarians teach BEAM to students who may struggle using a source once they have located it. A lesson plan is included as supplemental materials.

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The Preconstruction Of Foundation For A Greenhouse, Alla I. Hashim Dec 2021

The Preconstruction Of Foundation For A Greenhouse, Alla I. Hashim

Construction Management

This project outlines the preconstruction process for building a concrete base for a prefabricated greenhouse unit. This project was initiated by the Cal Poly Garden Club so they could plan for the installation of a greenhouse at the Student Experimental Farm on Cal Poly’s campus. The members of the club currently share a greenhouse with another Cal Poly Club which restricts their ability to use the greenhouse freely. The initial goal of the project was to request a permit, however, that will be postponed until the specific location is determined. This project still provides the necessary elements for requesting a …

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City Of Guadalupe Cultural Arts & Education Center Veterans Memorial Wall, Alejandra Arroyo Perez Dec 2021

City Of Guadalupe Cultural Arts & Education Center Veterans Memorial Wall, Alejandra Arroyo Perez

Construction Management

As a student in Construction Management, the importance of firsthand experience in the construction industry should not be taken lightly. The responsibility of every construction manager is to learn how to take a project from concept to reality. The primary five elements of construction management entail project programming, design development, material specifications, estimating, and scheduling. This paper documents the construction management process related to a Veterans Memorial Wall. Through coordination with the project stakeholders (i.e. property owners, engineer consultants, material fabricators, and vendors) a fully immersive construction management experience is gained. One of the stakeholder requirements was to establish a …

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Hybrid: The Future Of Construction Meetings In The Digital Age, Nicholas G. Orozco Dec 2021

Hybrid: The Future Of Construction Meetings In The Digital Age, Nicholas G. Orozco

Construction Management

Over the last few years, many construction companies have had to upheave traditional methods of construction meetings to adapt to rapidly changing COVID-19 safety and regulation protocols. For many, this has meant taking common in-person meetings (OAC, pre-construction, and design) and shifting them virtual. As companies continue to move forward in a post-pandemic climate, the question of whether they will continue with virtual meetings or revert to in-person meetings still lingers in the air. To get a better read on the future of construction meetings post-pandemic, a survey was sent to determine what most people prefer. A total of 21 …

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Forecasting Technology Trends Through The Gap Between Science And Technology: The Ase Of Software As An E-Commerce Service, Tugrul Daim, Esraa Bukhari, Dana Bakry, James Vanhuis, Haydar Yalcin, Xiaoli Wang Dec 2021

Forecasting Technology Trends Through The Gap Between Science And Technology: The Ase Of Software As An E-Commerce Service, Tugrul Daim, Esraa Bukhari, Dana Bakry, James Vanhuis, Haydar Yalcin, Xiaoli Wang

Engineering and Technology Management Faculty Publications and Presentations

Identifying technology trends can be a key success factor for companies to be competitive and take advantage of technological trends before they occur. The companies always work to plan for future products and services. For that, it is important to turn to methods that are used for technology forecasting. These tools help the companies to define potential markets for innovative new products and services. This paper uses text mining techniques along with expert judgment to detect and analyze the near-term technology evolution trends in a Software as a Service (SaaS) case study. The longer-term technology development trend in this case …

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A Design Build Company’S Pain Points For Field Staff Working Outside Of A Company’S Home Area, Mason Barber Dec 2021

A Design Build Company’S Pain Points For Field Staff Working Outside Of A Company’S Home Area, Mason Barber

Construction Management

Design-Build is the project-delivery system of the future but is not without pain points. The Design-Build system is an efficient form of project delivery that has a strong focus on relationships and can begin the construction phase while the design phase is still active. This study aims to identify and analyze the additional challenges or pain points that arise when Design-Build construction is taking place in an unfamiliar location and distant from the company office. The pain points are identified with field staff feedback through the form of survey responses. This study uses The Neenan Company as an example because …

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Protecting The Caed Shop Equipment Yard, Chloe K. Stevens Dec 2021

Protecting The Caed Shop Equipment Yard, Chloe K. Stevens

Construction Management

Anytime a construction project is considered, there is a lengthy process that happens before breaking ground. It is important to consider the environment around the project, the intended purpose and use of the space, and the materials, time, and budget needed to develop it. If you do not take these things into consideration correctly, it will negatively impact the functionality and the efficiency of both the use and the construction process. This project consists of creating a pre-construction plan for building out a weather protective and space efficient enclosure at the College of Architectural and Environmental Design Shop Yard. The …

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Granulated Blast Furnace Slag And Its Effects On Concrete Mixes, Adam Jacobson Dec 2021

Granulated Blast Furnace Slag And Its Effects On Concrete Mixes, Adam Jacobson

Construction Management

This paper explores what place slag, or granulated blast furnace slag has in our changing environment and evaluates how it compares to Portland cement. The purpose of this research is to discern how slag will be applicable in the future of construction and find what place it will have in concrete mixes. Slag is a Supplementary Cementitious Material (SCM) that is being utilized in more and more concrete applications due to its desirable properties and low environmental impact. Slag also reduces the amount of CO2 released that is produced in manufacturing and placing concrete. In this research, compressive strength of …

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Exploring The Relationships Between Gpa, Gender, Internship Participation, And Familial Influence In Salary And Salary Growth Of Construction Management Alumni, Kyra Leigh Glaus Dec 2021

Exploring The Relationships Between Gpa, Gender, Internship Participation, And Familial Influence In Salary And Salary Growth Of Construction Management Alumni, Kyra Leigh Glaus

Construction Management

College students seek to make themselves desirable to employers upon graduation, and employers use subjective and objective information to determine the best applicants. This study aims to survey the factors of college GPA, gender, internship experience, and familial influence and independently explore their relationship to career success as measured by starting salary and salary growth. A convenience sample was collected from construction management graduates from California Polytechnic State University, San Luis Obispo. The data for this sample found higher starting salaries for respondents who reported having higher GPAs, being female, having completed more internships, and who had an immediate family …

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Reimagining The Construction Vest Through The Facilitation Of A Hackathon, Cole Bernabei Dec 2021

Reimagining The Construction Vest Through The Facilitation Of A Hackathon, Cole Bernabei

Construction Management

This paper outlines the organizational process prior to hosting a Hackathon event in the upcoming year. When the event happens, it will be held in the Simpson Strong-Tie Building on California Polytechnic State University’s Campus. Data from a previous study shows that many individuals feel the current construction vest is flawed; the fit as currently designed is unfit for women. To resolve this, this paper will identify how a Hackathon can help produce a new prototype for the standard construction vest, while also highlighting the steps taken to develop a sound logistics plan and a financial breakdown for the event. …

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Attractive Features For San Luis Obispo's Collegiate Rental Market, Ava Bednarek Dec 2021

Attractive Features For San Luis Obispo's Collegiate Rental Market, Ava Bednarek

Construction Management

The purpose of this study is to analyze what college students would like to see in their rental units and would potentially pay more for if they had the option. It attempts to identify key features that would make valuable investments for rental unit owners. Data collection consisted of an anonymous online survey. Student respondents in the construction management major at California Polytechnic State University were asked questions regarding their current rental housing unit conditions and monthly rental costs. In addition, respondents were asked to further analyze the importance of a set list of features that could be added to …

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Summer Construction Bootcamp Building Activities, Ashley Leeann Isla Dec 2021

Summer Construction Bootcamp Building Activities, Ashley Leeann Isla

Construction Management

This paper outlines the trade-specific building activities that will take place at Cal Poly’s Summer Construction Bootcamp in Summer, 2022. The four construction trades that will be highlighted at the camp are concrete, carpentry, sheet metal, and plumbing. During each day, campers will build a small project that aligns with each highlighted construction trade. During the concrete day, campers will create stepping stones and perform a cylinder break test; during carpentry, campers will compete in a wall framing exercise; for sheet metal, campers will construct sheet metal roses; and for plumbing, they will make copper pipe “CPs.” This paper describes …

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Modular Interior Partitions In Commercial Housing: A Case Study, Adam David Meleo Dec 2021

Modular Interior Partitions In Commercial Housing: A Case Study, Adam David Meleo

Construction Management

The ability to modify an interior space with ease and reasonable cost is beneficial to designers, owners, and end-users. Modular interiors are not a new concept. Modular interior partitions can come in the form of Japanese Shoji screens, as well as folding walls that would be found in a convention center. While not new in concept, the market for products that allow partitioning an interior space with ease appears to be growing with the introduction of innovative products and solutions. This paper will focus on two student housing projects in San Luis Obispo, California, with regards to their design and …

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Analysis Of Self-Consolidating Concrete In Architectural Shear Wall Applications: Case Study, Peter Finocchio Dec 2021

Analysis Of Self-Consolidating Concrete In Architectural Shear Wall Applications: Case Study, Peter Finocchio

Construction Management

Architectural concrete surfaces have always been a point of focus for concrete contractors, architects, and owners, especially when consolidation poses risks due to a high density of reinforcement. Contractors have begun using self-consolidating concrete (SCC) in exposed vertical applications to combat the risk of poor consolidation. This paper investigates the characteristics of SCC and evaluates a case study of a recent project that was completed on the Central Coast of California. The study examines the cost variance between using SCC mix and a standard mix in architectural shear walls. The analysis is done by evaluating a multi-story Type 1A structure …

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San Luis Obispo Botanical Garden Amphitheater Benches - The Design, Devon Barthmaier Dec 2021

San Luis Obispo Botanical Garden Amphitheater Benches - The Design, Devon Barthmaier

Construction Management

This paper will outline the process of designing, building, and installing ten concrete benches at the San Luis Obispo Botanical Gardens with an emphasis on the design phase. The San Luis Obispo Botanical Gardens is home to an amphitheater that is used for event spaces. The goal of the project was to create a design to seat approximately forty people facing the stage. The project group consisted of six students broken into two teams, a pre-construction team and a construction team. The preconstruction team focused on designing the benches and procuring the materials while the construction team focused on the …

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Òpera, Diversitat, Inclusió: Una Reflexió A Partir D'Una Estrena A Nova York, Antoni Pizà Dec 2021

Òpera, Diversitat, Inclusió: Una Reflexió A Partir D'Una Estrena A Nova York, Antoni Pizà

Publications and Research

La inauguració de la temporada d’òpera a qualsevol ciutat important sol ser un gran esdeveniment i el Metropolitan Opera de Nova York (MET) no és cap excepció. És, lògicament, una nit de gala i tots els rituals de le grande monde es despleguen amb rigor litúrgic. Hi ha autoritats polítiques, naturalment, però sobretot lluminàries del món de les altes finances, la cultura i la ciència. Hi ha, també, sectors de la societat que no s’ho voldrien perdre per res del món: un petit univers d’estudiants de música tan ambiciosos com pobres i alguns grups com, el col·lectiu LGBTI+, molt discrets …

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A Safety Factor Approach To Designing Urban Infrastructure For Dynamic Conditions, Sanjib Sharma, Ben Seiyon Lee, Robert E. Nicholas, Klaus Keller Dec 2021

A Safety Factor Approach To Designing Urban Infrastructure For Dynamic Conditions, Sanjib Sharma, Ben Seiyon Lee, Robert E. Nicholas, Klaus Keller

Dartmouth Scholarship

Current approaches to design flood-sensitive infrastructure typically assume a stationary rainfall distribution and neglect many uncertainties. These assumptions are inconsistent with observations that suggest intensifying extreme precipitation events and the uncertainties surrounding projections of the coupled natural-human systems. Here we demonstrate a safety factor approach to designing urban infrastructure in a changing climate. Our results show that assuming climate stationarity and neglecting deep uncertainties can drastically underestimate flood risks and lead to poor infrastructure design choices. We find that climate uncertainty dominates the socioeconomic and engineering uncertainties that impact the hydraulic reliability in stormwater drainage systems. We quantify the upfront …

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Γδ T Cell Ifnγ Production Is Directly Subverted By Yersinia Pseudotuberculosis Outer Protein Yopj In Mice And Humans, Timothy H. Chu, Camille Khairallah, Jason Shieh, Rhea Cho, Zhijuan Qiu, Yue Zhang, Onur Eskiocak, David G. Thanassi, Mark H. Kaplan, Semir Beyaz, Vincent W. Yang, James B. Bliska, Brian S. Sheridan Dec 2021

Γδ T Cell Ifnγ Production Is Directly Subverted By Yersinia Pseudotuberculosis Outer Protein Yopj In Mice And Humans, Timothy H. Chu, Camille Khairallah, Jason Shieh, Rhea Cho, Zhijuan Qiu, Yue Zhang, Onur Eskiocak, David G. Thanassi, Mark H. Kaplan, Semir Beyaz, Vincent W. Yang, James B. Bliska, Brian S. Sheridan

Dartmouth Scholarship

Yersinia pseudotuberculosis is a foodborne pathogen that subverts immune function by translocation of Yersinia outer protein (Yop) effectors into host cells. As adaptive γδ T cells protect the intestinal mucosa from pathogen invasion, we assessed whether Y. pseudotuberculosis subverts these cells in mice and humans. Tracking Yop translocation revealed that the preferential delivery of Yop effectors directly into murine Vγ4 and human Vδ2+ T cells inhibited anti-microbial IFNγ production. Subversion was mediated by the adhesin YadA, injectisome component YopB, and translocated YopJ effector. A broad anti-pathogen gene signature and STAT4 phosphorylation levels were inhibited by translocated YopJ. Thus, Y. pseudotuberculosis …

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Associations Between Postpartum Depression And Assistance With Household Tasks And Childcare During The Covid-19 Pandemic: Evidence From American Mothers, Theresa E. Gildner, Glorieuse Uwizeye, Rebecca L. Milner, Grace C. Alston, Zaneta M. Thayer Dec 2021

Associations Between Postpartum Depression And Assistance With Household Tasks And Childcare During The Covid-19 Pandemic: Evidence From American Mothers, Theresa E. Gildner, Glorieuse Uwizeye, Rebecca L. Milner, Grace C. Alston, Zaneta M. Thayer

Dartmouth Scholarship

Background: The early postpartum period is recognized cross-culturally as being important for recovery, with new parents receiving increased levels of community support. However, COVID-19-related lockdown measures may have disrupted these support systems, with possible implications for mental health. Here, we use a cross-sectional analysis among individuals who gave birth at different stages of the pandemic to test (i) if instrumental support access in the form of help with household tasks, newborn care, and care for older children has varied temporally across the pandemic, and (ii) whether access to these forms of instrumental support is associated with lower postpartum depression scores. …

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Integrating Satellite, Uav, And Ground-Based Remote Sensing In Archaeology: An Exploration Of Pre-Modern Land Use In Northeastern Iraq, Elise Jakoby Laugier, Jesse Casana Dec 2021

Integrating Satellite, Uav, And Ground-Based Remote Sensing In Archaeology: An Exploration Of Pre-Modern Land Use In Northeastern Iraq, Elise Jakoby Laugier, Jesse Casana

Dartmouth Scholarship

Satellite remote sensing is well demonstrated to be a powerful tool for investigating ancient land use in Southwest Asia. However, few regional studies have systematically integrated satellite-based observations with more intensive remote sensing technologies, such as drone-deployed multispectral sensors and ground-based geophysics, to explore off-site areas. Here, we integrate remote sensing data from a variety of sources and scales including historic aerial photographs, modern satellite imagery, drone-deployed sensors, and ground-based geophysics to explore pre-modern land use along the Upper Diyala/Sirwan River in the Kurdistan Region of Iraq. Our analysis reveals an incredible diversity of land use features, including canals, qanats, …

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Maternal Depression Trajectories And Child Bmi In A Multi-Ethnic Sample: A Latent Growth Modeling Analysis, Charlotte V. Farewell, Ryley Donohoe, Zaneta Thayer, James Paulson, Jacinda Nicklas, Caroline Walker, Karen Waldie, Jenn A. Leiferman Dec 2021

Maternal Depression Trajectories And Child Bmi In A Multi-Ethnic Sample: A Latent Growth Modeling Analysis, Charlotte V. Farewell, Ryley Donohoe, Zaneta Thayer, James Paulson, Jacinda Nicklas, Caroline Walker, Karen Waldie, Jenn A. Leiferman

Dartmouth Scholarship

Background: Perinatal (antenatal and postpartum) depression impacts approximately 12% of mothers. Perinatal depression can impact everyday functioning for mothers, and the relationship with, and development of, their children. The purpose of this study was to investigate depression trajectories from the antenatal period through 54-months postpartum and associations with child body mass index at 54-months postpartum. Methods: This study applied latent growth modeling to the Growing Up in New Zealand study, which is a longitudinal pregnancy cohort study that provides nationally representative-level data, to investigate associations between depression at three time points (antenatal, 9-months postpartum, 54-months postpartum) and child body mass …

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Ct For Estimating Adequacy Of Lymph Node Dissection In Patients With Squamous Cell Carcinoma Of The Head And Neck, Christiaan A. Rees, Joshua H. Litchman, Xiaotian Wu, Mariah M. Servos, Darcy A. Kerr, Ryan J. Halter, David A. Pastel, Joseph A. Paydarfar Dec 2021

Ct For Estimating Adequacy Of Lymph Node Dissection In Patients With Squamous Cell Carcinoma Of The Head And Neck, Christiaan A. Rees, Joshua H. Litchman, Xiaotian Wu, Mariah M. Servos, Darcy A. Kerr, Ryan J. Halter, David A. Pastel, Joseph A. Paydarfar

Dartmouth Scholarship

Background: Indices obtained from lymph node dissection specimens, specifically lymph node yield (LNY) and lymph node ratio (LNR), have prognostic significance in the setting of head and neck squamous cell carcinoma (HNSCCa). However, there are currently no validated tools to estimate adequacy of planned lymph node dissection using preoperative data. The present study sought to evaluate CT-derived estimates of lymphatic tissue volumes as a preoperative tool to guide cervical node dissection. Methods: Fifteen cervical lymph node dissections were performed in 14 subjects with HNSCCa. Preoperative CT-derived estimates of lymphatic tissue volumes were compared with gross pathology tissue volume estimates and …

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A Distributed Fmri-Based Signature For The Subjective Experience Of Fear, Feng Zhou, Weihua Zhao, Ziyu Qi, Yayuan Geng, Shuxia Yao, Keith M. Kendrick, Tor D. Wager, Benjamin Becker Dec 2021

A Distributed Fmri-Based Signature For The Subjective Experience Of Fear, Feng Zhou, Weihua Zhao, Ziyu Qi, Yayuan Geng, Shuxia Yao, Keith M. Kendrick, Tor D. Wager, Benjamin Becker

Dartmouth Scholarship

The specific neural systems underlying the subjective feeling of fear are debated in affective neuroscience. Here, we combine functional MRI with machine learning to identify and evaluate a sensitive and generalizable neural signature predictive of the momentary self-reported subjective fear experience across discovery (n = 67), validation (n = 20) and generalization (n = 31) cohorts. We systematically demonstrate that accurate fear prediction crucially requires distributed brain systems, with important contributions from cortical (e.g., prefrontal, midcingulate and insular cortices) and subcortical (e.g., thalamus, periaqueductal gray, basal forebrain and amygdala) regions. We further demonstrate that the neural representation of subjective fear …

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Spectral Analysis Of Climate Dynamics With Operator-Theoretic Approaches, Gary Froyland, Dimitrios Giannakis, Benjamin R. Lintner, Maxwell Pike, Joanna Slawinska Dec 2021

Spectral Analysis Of Climate Dynamics With Operator-Theoretic Approaches, Gary Froyland, Dimitrios Giannakis, Benjamin R. Lintner, Maxwell Pike, Joanna Slawinska

Dartmouth Scholarship

The Earth’s climate system is a classical example of a multiscale, multiphysics dynamical system with an extremely large number of active degrees of freedom, exhibiting variability on scales ranging from micrometers and seconds in cloud microphysics, to thousands of kilometers and centuries in ocean dynamics. Yet, despite this dynamical complexity, climate dynamics is known to exhibit coherent modes of variability. A primary example is the El Niño Southern Oscillation (ENSO), the dominant mode of interannual (3–5 yr) variability in the climate system. The objective and robust characterization of this and other important phenomena presents a long-standing challenge in Earth system …

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Color Cherenkov Imaging Of Clinical Radiation Therapy, Daniel A. Alexander, Anthony Nomezine, Lesley A. Jarvis, David J. Gladstone, Brian W. Pogue, Petr Bruza Dec 2021

Color Cherenkov Imaging Of Clinical Radiation Therapy, Daniel A. Alexander, Anthony Nomezine, Lesley A. Jarvis, David J. Gladstone, Brian W. Pogue, Petr Bruza

Dartmouth Scholarship

Color vision is used throughout medicine to interpret the health and status of tissue. Ionizing radiation used in radiation therapy produces broadband white light inside tissue through the Cherenkov effect, and this light is attenuated by tissue features as it leaves the body. In this study, a novel time-gated three-channel camera was developed for the first time and was used to image color Cherenkov emission coming from patients during treatment. The spectral content was interpreted by comparison with imaging calibrated tissue phantoms. Color shades of Cherenkov emission in radiotherapy can be used to interpret tissue blood volume, oxygen saturation and …

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Developing Diagnostic Assessment Of Breast Lumpectomy Tissues Using Radiomic And Optical Signatures, Samuel S. Streeter, Brady Hunt, Rebecca A. Zuurbier, Wendy A. Wells, Keith D. Paulsen, Brian W. Pogue Dec 2021

Developing Diagnostic Assessment Of Breast Lumpectomy Tissues Using Radiomic And Optical Signatures, Samuel S. Streeter, Brady Hunt, Rebecca A. Zuurbier, Wendy A. Wells, Keith D. Paulsen, Brian W. Pogue

Dartmouth Scholarship

High positive margin rates in oncologic breast-conserving surgery are a pressing clinical problem. Volumetric X-ray scanning is emerging as a powerful ex vivo specimen imaging technique for analyzing resection margins, but X-rays lack contrast between non-malignant and malignant fibrous tissues. In this study, combined micro-CT and wide-field optical image radiomics were developed to classify malignancy of breast cancer tissues, demonstrating that X-ray/optical radiomics improve malignancy classification. Ninety-two standardized features were extracted from co-registered micro-CT and optical spatial frequency domain imaging samples extracted from 54 breast tumors exhibiting seven tissue subtypes confirmed by microscopic histological analysis. Multimodal feature sets improved classification …

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Diverse Antiviral Igg Effector Activities Are Predicted By Unique Biophysical Antibody Features, Hao D. Cheng, Karen G. Dowell, Chris Bailey-Kellogg, Brittany A. Goods, J. Christopher Love, Guido Ferrari, Galit Alter, Johannes Gach, Donald N. Forthal, George K. Lewis, Kelli Greene, Hongmei Gao, David C. Montefiori, Margaret E. Ackerman Dec 2021

Diverse Antiviral Igg Effector Activities Are Predicted By Unique Biophysical Antibody Features, Hao D. Cheng, Karen G. Dowell, Chris Bailey-Kellogg, Brittany A. Goods, J. Christopher Love, Guido Ferrari, Galit Alter, Johannes Gach, Donald N. Forthal, George K. Lewis, Kelli Greene, Hongmei Gao, David C. Montefiori, Margaret E. Ackerman

Dartmouth Scholarship

Background: The critical role of antibody Fc-mediated effector functions in immune defense has been widely reported in various viral infections. These effector functions confer cellular responses through engagement with innate immune cells. The precise mechanism(s) by which immunoglobulin G (IgG) Fc domain and cognate receptors may afford protection are poorly understood, however, in the context of HIV/SHIV infections. Many different in vitro assays have been developed and utilized to measure effector functions, but the extent to which these assays capture distinct antibody activities has not been fully elucidated. Results: In this study, six Fc-mediated effector function assays and two biophysical …

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