Digital Commons Network^™

Mission-Based Filters In The Electronic Residency Application Service: Saving Time And Promoting Diversity, Jennifer L Swails, Sasha Adams, Mark Hormann, Emma Omoruyi, Omowunmi Aibana

Faculty, Staff and Student Publications

BACKGROUND: Holistic review promotes diversity, but widespread implementation remains limited.

OBJECTIVE: We aimed to develop a practical approach to incorporate holistic review principles in screening applicants in the Electronic Residency Application Service (ERAS) and to assess the impact on diversity.

METHODS: Three residency programs (internal medicine [IM], pediatrics, and surgery) at McGovern Medical School developed filters to identify applicants with experiences/attributes aligned with the institutional mission. These filters were retroactively applied to each program's 2019-2020 applicant pool using built-in ERAS capabilities to group applicants by user-defined features. We compared the demographics of applicants reviewed during the cycle with those identified …

Long-Term Impacts Faced By Patients And Families After Harmful Healthcare Events, Madelene J Ottosen, Emily W Sedlock, Aitebureme O Aigbe, Sigall K Bell, Thomas H Gallagher, Eric J Thomas

Faculty, Staff and Student Publications

BACKGROUND: Patients and families report experiencing a multitude of harms from medical errors resulting in physical, emotional, and financial hardships. Little is known about the duration and nature of these harms and the type of support needed to promote patient and family healing after such events. We sought to describe the long-term impacts (LTIs) reported by patients and family members who experienced harmful medical events 5 or more years ago.

METHODS: We performed a content analysis on 32 interviews originally conducted with 72 patients or family members about their views of the factors contributing to their self-reported harmful event. Interviews …

Patient-Derived Ipscs Link Elevated Mitochondrial Respiratory Complex I Function To Osteosarcoma In Rothmund-Thomson Syndrome, Brittany E Jewell, An Xu, Dandan Zhu, Mo-Fan Huang, Linchao Lu, Mo Liu, Erica L Underwood, Jun Hyoung Park, Huihui Fan, Julian A Gingold, Ruoji Zhou, Jian Tu, Zijun Huo, Ying Liu, Weidong Jin, Yi-Hung Chen, Yitian Xu, Shu-Hsia Chen, Nino Rainusso, Nathaniel K Berg, Danielle A Bazer, Christopher Vellano, Philip Jones, Holger K Eltzschig, Zhongming Zhao, Benny Abraham Kaipparettu, Ruiying Zhao, Lisa L Wang, Dung-Fang Lee

Faculty, Staff and Student Publications

Rothmund-Thomson syndrome (RTS) is an autosomal recessive genetic disorder characterized by poikiloderma, small stature, skeletal anomalies, sparse brows/lashes, cataracts, and predisposition to cancer. Type 2 RTS patients with biallelic RECQL4 pathogenic variants have multiple skeletal anomalies and a significantly increased incidence of osteosarcoma. Here, we generated RTS patient-derived induced pluripotent stem cells (iPSCs) to dissect the pathological signaling leading to RTS patient-associated osteosarcoma. RTS iPSC-derived osteoblasts showed defective osteogenic differentiation and gain of in vitro tumorigenic ability. Transcriptome analysis of RTS osteoblasts validated decreased bone morphogenesis while revealing aberrantly upregulated mitochondrial respiratory complex I gene expression. RTS osteoblast metabolic assays …

A Fine-Grained Attribute Based Data Retrieval With Proxy Re-Encryption Scheme For Data Outsourcing Systems, Hanshu Hong, Ximeng Liu, Zhixin Sun

Research Collection School Of Computing and Information Systems

Attribute based encryption is suitable for data protection in data outsourcing systems such as cloud computing. However, the leveraging of encryption technique may retrain some routine operations over the encrypted data, particularly in the field of data retrieval. This paper presents an attribute based date retrieval with proxy re-encryption (ABDR-PRE) to provide both fine-grained access control and retrieval over the ciphertexts. The proposed scheme achieves fine-grained data access management by adopting KP-ABE mechanism, a delegator can generate the re-encryption key and search indexes for the ciphertexts to be shared over the target delegatee’s attributes. Throughout the process of data sharing, …

Reassessing Associations Between White Matter And Behaviour With Multimodal Microstructural Imaging, Alberto Lazari, Piergiorgio Salvan, Michiel Cottaar, Daniel Papp, Olof Jens Van Der Werf, Ainslie Johnstone, Zeena-Britt Sanders, Cassandra Sampaio-Baptista, Nicole Eichert, Anderson M. Winkler

School of Medicine Publications

Several studies have established specific relationships between White Matter (WM) and behaviour. However, these studies have typically focussed on fractional anisotropy (FA), a neuroimaging metric that is sensitive to multiple tissue properties, making it difficult to identify what biological aspects of WM may drive such relationships. Here, we carry out a pre-registered assessment of WM-behaviour relationships in 50 healthy individuals across multiple behavioural and anatomical domains, and complementing FA with myelin-sensitive quantitative MR modalities (MT, R1, R2∗).

Surprisingly, we only find support for predicted relationships between FA and behaviour in one of three pre-registered tests. For one behavioural domain, …

Neuroimaging Association Scores: Reliability And Validity Of Aggregate Measures Of Brain Structural Features Linked To Mental Disorders In Youth, Luiza Kvitko Axelrud, André Rafael Simioni, Daniel Samuel Pine, Anderson M. Winkler, Pedro Mario Pan, João Ricardo Sato, André Zugman, Nadine Parker, Felipe Picon, Andrea Jackowski

School of Medicine Publications

In genetics, aggregation of many loci with small effect sizes into a single score improved prediction. Nevertheless, studies applying easily replicable weighted scores to neuroimaging data are lacking. Our aim was to assess the reliability and validity of the Neuroimaging Association Score (NAS), which combines information from structural brain features previously linked to mental disorders. Participants were 726 youth (aged 6–14) from two cities in Brazil who underwent MRI and psychopathology assessment at baseline and 387 at 3-year follow-up. Results were replicated in two samples: IMAGEN (n = 1627) and the Healthy Brain Network (n = 843). NAS …

Toward Rehumanization: Creolized Solidarity And Practical Empathy, Michelle India Miller

Electronic Theses and Dissertations Archive

This project seeks to engage political theory surrounding processes of creolization and solidarity, as well as their usefulness towards political movements. Current socialization within the United States promotes individualism and, as a result, an inability to see how various sociopolitical issues interact with one another and affect large portions of the population in ways that are not always obvious. Through a commitment to open engagement and practical empathy, creolized solidarity could provide a baseline from which to evaluate prevalent issues as well as our relationships with one another, the natural connection that comes from simply being human.

Anatomy Lesson Paintings: A Survey Of Progression In The Medical And Anatomical Fields, Heather Reyanne Jeffery

Electronic Theses and Dissertations Archive

This study has emerged through a combination of art and science, visually and contextually analyzing anatomy lesson paintings as commemorations of physicians, artists, and medical and anatomical advancements. This study focuses on the works of five major artists through the Dutch Baroque and American Realist periods: Michiel Janszoon van Mierevelt, Rembrandt Harmenszoon van Rijn, Thomas Cowperthwait Eakins, Albert Sands Southworth, and Josiah Johnson Hawes. Chapter One begins with Andreas Vesalius, laying the groundwork for the depictions and spread of information for medical advances in the seventeenth and nineteenth centuries. Chapters Two and Three respectively consider depictions of Baroque and then …

Latent Tuberculosis Infection In A Patient With A Negative Interferon Gamma Release Assay Prior To Biologic Initiation For Crohn's Disease, Muaaz Masood, Reid Wasserman, Vignesh Nagesh, Humberto Sifuentes

Student Publications

CASE: Biologic therapy has revolutionized the treatment of inflammatory bowel disease (IBD). Nevertheless, it is well known that biologics are associated with an increased risk of opportunistic infections such as tuberculosis (TB). Screening tests indicated before biologic initiation, namely interferon gamma release assay (IGRA) or tuberculin skin tests (TST), may be falsely negative. We present the case of a male with uncontrolled Crohn’s disease (CD) with a negative screen for TB and how a high index of suspicion led to the discovery of latent tuberculosis infection (LTBI) and the appropriate deferment of biologic therapy. A 63-year-old South Asian male with …

Is Surgery Essential For Management Of High Grade Neuroendocrine Carcinoma Of The Breast? A Case Report And Review, Dakota Sudbeck, Boban N. Mathew

Student Publications

High grade neuroendocrine carcinoma of the breast (HGNCB) is an aggressive and rare primary breast malignancy. No standard management recommendations exist for this entity and they are managed similarly as traditional breast cancers. Here we present the first case of a 54 year old female with high grade neuroendocrine carcinoma of the breast managed non-surgically with concurrent chemoradiation. At the time of this publication, she is more than 8 years from diagnosis without evidence of recurrence.

Can Minimally Invasive Surgery Still Be Done For Cervical Cancer Patients Considering The Lacc Trial?, Sichen Liang, Zhiqing Liang, Samar Nahas, Jianming Song, Zeyi Cao, Adel Shervin, Bruno J. Van Herendael, Jennifer Song, Jianliu Wang

Student Publications

No abstract provided.

Using The Cataloguing Code Of Ethics Principles For A Retrospective Project Analysis, Angela Yon, Eric Willey

Faculty and Staff Publications – Milner Library

This study uses the recently released Cataloguing Code of Ethics to evaluate a project which explored how to ethically, efficiently, and accurately add demographic terms for African American authors to catalog records. By reviewing the project through the lens of these principles the authors were able to examine how their practice was ethical in some ways but could have been improved in others. This helped them identify areas of potential improvement in their current and future research and practice and explore ethical difficulties in cataloging resources with records that are used globally, especially in a linked data environment.

Force And Torque Model Sensitivity And Coarse Graining For Bedload-Dominated Sediment Transport, Liheng Guan, Jorge Salinas, ‪Nadim Zgheib, S. Balachandar

Mechanical Engineering Faculty Publications

We present results from Euler–Lagrange simulations of turbulent flow over an erodible monodisperse bed of particles at a shear Reynolds number of R e τ = 180 . The Galileo number G a and the ratio of Shields to the critical Shields number Θ / θ c r were varied in the range 11.4 to 29.8 and 1.32 to 5.98, respectively. Two drag force models were investigated along with the influence of lift, particle rotation, and tangential collision forces for each model. Both models give similar results as far as mean particle flux and Shields stress are concerned, however we …

Searching For Imaging Biomarkers Of Psychotic Dysconnectivity, Amanda L. Rodrigue, Dana Mastrovito, Oscar Esteban, Joke Durnez, Marinka M. G. Koenis, Ronald Janssen, Aaron Alexander-Bloch, Emma M. Knowles, Samuel R. Mathias, John Blangero

School of Medicine Publications

Background: Progress in precision psychiatry is predicated on identifying reliable individual-level diagnostic biomarkers. For psychosis, measures of structural and functional connectivity could be promising biomarkers given consistent reports of dysconnectivity across psychotic disorders using magnetic resonance imaging.

Methods: We leveraged data from four independent cohorts of patients with psychosis and control subjects with observations from approximately 800 individuals. We used group-level analyses and two supervised machine learning algorithms (support vector machines and ridge regression) to test within-, between-, and across-sample classification performance of white matter and resting-state connectivity metrics.

Results: Although we replicated group-level differences in brain connectivity, individual-level classification …

Anterior-Posterior Axis Of Hippocampal Subfields Across Psychoses: A B-Snip Study, Elisabetta C. Del Re, Victor Zeng, Ney Alliey-Rodriguez, Paulo Lizano, Nicolas Bolo

School of Medicine Publications

Background: The hippocampus (HP) is affected across psychoses, including schizophrenia (SZ), bipolar type 1 (BDP) and schizoaffective (SAD) disorders. We examined HP subfield volumetric abnormalities along the anterior-posterior (ventral-dorsal) axis of the HP in psychosis probands, defined by traditional (DSM) diagnoses and biologically defined subtypes (biotypes, based on cognition and electrophysiology). We hypothesized that biotypes would be better discriminated by HP longitudinal axis subfields abnormalities than DSM. Methods: The sample included 455 probands from the Bipolar Schizophrenia Network for intermediate Phenotypes (BSNIP) dataset (age 35 ± 12.0): 124 unaffected (age 40.4 ± 15.8) and 299 healthy controls (HC; 37 ± …

Absence Of Coding Somatic Single Nucleotide Variants Within Well-Known Candidate Genes In Late-Onset Sporadic Alzheimer's Disease Based On The Analysis Of Multi-Omics Data, Shishi Min, Zongchang Li, Annie Shieh, Gina Giase, Ney Alliey Rodriguez

School of Medicine Publications

Somatic mutations arise randomly or are induced by environmental factors, which may increase the risk of Alzheimer's disease (AD). Identifying somatic mutations in sporadic AD (SAD) may provide new insight of the disease. To evaluate the potential contribution of somatic single nucleotide variations (SNVs), particularly that of well-known AD-candidate genes, we investigated sequencing data sets from four platforms: whole-genome sequencing (WGS), deep whole-exome sequencing (WES) on paired brain and liver samples, RNA sequencing (RNA-seq), and single-cell whole-genome sequencing (scWGS) of brain samples from 16 AD patients and 16 non-AD individuals. We found that the average number, mean variant allele fractions …

Clinical Predictors Of Non-Response To Lithium Treatment In The Pharmacogenomics Of Bipolar Disorder (Pgbd) Study, Yian Lin, Adam X. Maihofer, Emma Stapp, Megan Ritchey, Ney Alliey Rodriguez

School of Medicine Publications

Background: Lithium is regarded as a first-line treatment for bipolar disorder (BD), but partial response and non-response commonly occurs. There exists a need to identify lithium non-responders prior to initiating treatment. The Pharmacogenomics of Bipolar Disorder (PGBD) Study was designed to identify predictors of lithium response.

Methods: The PGBD Study was an eleven site prospective trial of lithium treatment in bipolar I disorder. Subjects were stabilized on lithium monotherapy over 4 months and gradually discontinued from all other psychotropic medications. After ensuring a sustained clinical remission (defined by a score of ≤3 on the CGI for 4 weeks) had been …

Smooth Loops And Loop Bundles, Sergey Grigorian

School of Mathematical & Statistical Sciences Faculty Publications

A loop is a rather general algebraic structure that has an identity element and division, but is not necessarily associative. Smooth loops are a direct generalization of Lie groups. A key example of a non-Lie smooth loop is the loop of unit octonions. In this paper, we study properties of smooth loops and their associated tangent algebras, including a loop analog of the Maurer-Cartan equation. Then, given a manifold, we introduce a loop bundle as an associated bundle to a particular principal bundle. Given a connection on the principal bundle, we define the torsion of a loop bundle structure and …

Combined Amplification And Sound Therapy For Individuals With Tinnitus And Coexisting Hearing Loss: A Retrospective Cohort Study, Purushothaman Ganesan, Hansapani Rodrigo, Jason Schmiedge, Rob Reiter, Simham Swapna, Vinaya Manchaiah

School of Mathematical & Statistical Sciences Faculty Publications

BACKGROUND: The heterogeneity of tinnitus perception and its impact necessitates a tailor-made management approach in everyone. The current study examined the effects of residual inhibition in combined amplification and sound therapy in individuals with tinnitus and coexisting hearing loss.

METHODS: A retrospective analysis was performed on patients with tinnitus and coexisting hearing loss between 2016 and 2019. A total of 72 patients provided with combined amplification and sound therapy were divided into 3 groups based on residual inhibition: (i) complete residual inhibition, (ii) partial residual inhibition, and (iii) negative residual inhibition. Tinnitus severity was measured using the Tinnitus …

Polynomial Embeddings Of Unilateral Weighted Shifts In 2-Variable Weighted Shifts, Raul E. Curto, Sang H. Lee, Jasang Yoon

School of Mathematical & Statistical Sciences Faculty Publications

Given a bounded sequence omega of positive numbers, and its associated unilateral weighted shift W-omega, acting on the Hilbert space l(2) (Z+), we consider natural representations of W-omega as a 2-variable weighted shift, acting on the Hilbert space l(2)(Z(+)(2)). Alternatively, we seek to examine the various ways in which the sequence omega can give rise to a 2-variable weight diagram, corresponding to a 2-variable weighted shift. Our best (and more general) embedding arises from looking at two polynomials p and q nonnegative on a closed interval I subset of R+ and the double-indexed moment sequence {integral p(r)(k) q(r)(l) d sigma(r)}(k,l …

Redhawks Men's Soccer Soar In Spectacular Fashion To Win The Wac, George Burquest

The Spectator Online

No abstract provided.

Redhawks Reckon With Resignation, Matt Price, Cielita Maguddayao

The Spectator Online

No abstract provided.

Week In Review: Nov. 15 - Nov. 21, Claire Hood

The Spectator Online

No abstract provided.

Additive Manufacturing Of Cork, A Cold Spray Technology, Kimberly Kay Dickey

Theses and Dissertations

Cold Spray Additive Manufacturing is a technology capable of mass manufacturing components with complicated geometry and coating substrates in hard-to-reach areas. In addition, cold spray also has the ability of conducting a green manufacturing process, with zero waste of renewable feed material, and zero gas and chemical emission. This paper investigates solely cold spray as an additive manufacturing technology with cork as the natural material. CFD results were used to predict the physical behavior of air and the cork particles. After unsuccessful coatings, final results showed that when moisture is added, cork is successfully cold sprayed, and agglomeration is experienced. …

The Role Of Nutrient Supplementation In The Management Of Chronic Pain In Fibromyalgia: A Narrative Review, Hannah Haddad, Nikita Reddy Mallepalli, John Emerson Scheinuk, Pranav Bhargava, Elyse M. Cornett, Ivan Urits, Alan D. Kaye

Student Publications

Introduction: The multifaceted clinical presentation of fibromyalgia (FM) supports the modern understanding of the disorder as a more global condition than one simply affecting pain sensation. The main pharmacologic therapies used clinically include anti-epileptics and anti-depressants. Conservative treatment options include exercise, myofascial release, psychotherapy, and nutrient supplementation.

Methods: Narrative review.

Results: Nutrient supplementation is a broadly investigated treatment modality as numerous deficiencies have been linked to FM. Additionally, a proposed link between gut microbiome patterns and chronic pain syndromes has led to studies investigating probiotics as a possible treatment. Despite positive results, much of the current evidence regarding this topic …

How Should Medical Schools Foster Equity And Inclusion In Admissions?, Adela Valdez, Lala Forrest, Alessandra Jimenez, Kim-Thu Pham

School of Medicine Publications

This commentary in response to a case considers how merit and features of medical school applicants’ dossiers should be drawn upon in admissions processes to promote equity and inclusion in medicine. It is argued that medical schools should incentivize inclusion by redefining merit in their admissions goals and processes, promote meaningful inclusion, and show institutional leadership in addressing social justice.

Cultivating A Community Of Practice Model To Support And Encourage Innovative T&L Practices To Engage Practitioners And Enhance Student Success, Jen Harvey, Derek Dodd, Catherine Deegan, Olivia Freeman, Cormac H. Macmahon, Helen Williams

Irish Journal of Academic Practice

Communities of Practice (CoPs) are naturally forming groups of individuals who come together through a shared passion or goal and learn collectively by reciprocating knowledge and experiences. With competing demands of faculty, universities are increasingly challenged to provide professional development opportunities that actively encourage innovative pedagogical practices to enhance student success and quality of the learner experience. We report on four embryonic CoPs, based on collaborative processes, supporting institutional transformation and the formation of a new education model at Ireland’s first Technological University (TU). Juxtaposing a series of planned learning innovations with spontaneous interactions and actions of CoP members, we …

Introduction To The Impact Special Issue, Barry J. Ryan

Irish Journal of Academic Practice

In this Introduction, an overview of the IMPACT Special Issue is presented. The context of the IMPACT project is described and explained. A short summary is given for each of the papers that follow. Readers are invited to read the Special Issue, access the IMPACT project website, and connect with authors and project leads.

Foundations And Scaffolding: Exploring Literature And Practice To Build A New Curriculum Framework For Tu Dublin, Claire Mcavinia, Odette Gabaudan, Olivia Freeman, Barry J. Ryan, Colm O'Kane, Robert Tully

Irish Journal of Academic Practice

The IMPACT project at TU Dublin has been informed in part by the outcomes of the Co-CREATE project in 2019-20. Co-CREATE was a Team Teaching Fellowship project to support and underpin the building of a quality curriculum framework for the new technological university. A number of IMPACT projects (for example, NorthStar) have continued the work started within the Co-CREATE project to make it sustainable and embedded within the university. We present findings from one element of the Co-CREATE project which has informed a range of initiatives in IMPACT. This is the review of literature and practice undertaken to underpin the …

Exploring Enablers And Barriers To Educator Engagement In Teaching Innovation, Linda Moore, Catherine Spencer, David Gaul

Irish Journal of Academic Practice

This paper explores the literature related to educator engagement in teaching, learning, assessment and feedback innovation (further referred to here as ‘teaching innovation’) in higher education institutions, describing the main enablers and barriers to innovation. These include consideration of formal and informal learning opportunities for educators, the role of management and leadership, as well as recognition and reward systems, teaching-research conflict, workload and time demands, and policies and procedures. These are examined within the Job Demands-Resources (JD-R) model as job resources and job demands to facilitate understanding of how these may influence educator engagement in teaching innovation in interaction with …