Digital Commons Network^™

Design, Synthesis And Characterization Of Carbohydrate Based Macrocycles, Photo Responsive Derivatives, And Glycoconjugates Based Low Molecular Weight Gelators, Surya Bahadur Adhikari

Chemistry & Biochemistry Theses & Dissertations

Functional glycoconjugates are important classes of compounds with many applications in different research fields. Our lab has been studying the synthesis and applications of different classes of glycoconjugates ranging from macrocycles to sugar heterocycle derivatives. Due to the importance of these compounds, our research is based on development of synthetic methods for various carbohydrate derivatives. This dissertation includes introduction and overview of projects, followed by the synthesis and studies of several different series of glycomacrolactones. The second project focuses on two classes of photoresponsive molecules, the coumarins and diarylethenes. The third project involves the synthesis and self-assembling properties of isoxazole-based …

On The P-Inner Functions Of ℓPA, James G. Dragas

Mathematics & Statistics Theses & Dissertations

Define ℓ^p_A as the space of all functions holomorphic over the unit disk whose Taylor coefficients are p-summable. Despite their classical origins and simple definition, these spaces are not as well understood as one might expect. This is particularly true when compared with the Hardy spaces, which provide a useful road map for the types of questions we might consider reasonable. In this work we examine the zero sets of ℓ^p_A, p ∈ (1;∞), as well as a notion of inner function that is consistent with the approach taken on numerous other function spaces. …

Subtalar Joint Definition In Biomechanical Models, Julia Noginova

Biomedical Engineering Theses & Dissertations

The effect of including a subtalar joint in a dynamic musculoskeletal model has not been fully explored or validated. The subtalar joint is often modeled as a one DOF hinge with the tri-planar axis defined as a combination of inclination and deviation angles measured from the ground and midline of the foot, respectively. The overall purposes of this dissertation were to explore how the inclusion of the subtalar joint and the definition of origin location and axis orientation affect the kinematics, joint kinetics, and muscle activations of the knee, ankle, and subtalar joint during dynamic tasks of walking and running …

Phytoplankton Community Response To Upwelling Events: Distribution And Abundance Investigated Using Genomic Methods, Sveinn V. Einarsson

OES Theses and Dissertations

Upwelling events are known to support blooms of phytoplankton, important primary producers at the base of the oceanic food web. Phytoplankton community structure changes in response to upwelling support higher trophic level growth and increased efficiency of carbon export from the euphotic zone. While these events occur globally, this study examined upwelling in coastal regions, where alongshore winds can drive Ekman transport and upwelling of deeper waters. The two upwelling regimes examined were the California Current System and the Alaskan Beaufort Sea. In the California Current System, the relative diatom community composition was examined using 18S sequencing to determine how …

The Effects Of Depression, Anxiety, And Stress On College Students: Examining The Role Of Mental Health Self-Efficacy On Willingness To Engage In Mental Health Services, Leeanna L. Golembiewski

Psychology Theses & Dissertations

Relative to younger ages, mental health problems are more prevalent among college students (Pedrelli et al., 2015) and nearly 20% of U.S college students are diagnosed each year with a mental health problem (Blanco et al., 2008). College students’ self-efficacy may influence mental health outcomes by impacting an individual’s decision to change their behavior and execute a course of action (Bresó et al., 2011). Mental health may also be influenced by the degree of willingness that an individual possesses, such that those who are more willing to seek mental health treatment are also more likely to follow through and seek …

Generation, Analysis, And Evaluation Of Patient-Specific, Osteoligamentous, Spine Meshes, Austin R. Tapp

Biomedical Engineering Theses & Dissertations

Scoliosis, an abnormal curvature of the spine, is traditionally corrected with bracing treatments or by a highly invasive posterior spinal fusion (PSF) operation. These correction strategies are constrained by current imaging modalities, which fail to elucidate the soft tissue anatomy that is known to play a critical role in spinal stiffness and overall structure. Osteoligamentous segmentations of the spinal column offer a foundation for downstream finite element (FE) studies seeking to optimize bracing treatments or determine ideal surgical approaches.

This thesis presents methods for automatically and semi-automatically segmenting vertebrae and surrounding soft tissues of the spinal column using X-ray computed …

Assessment Of The Hydrograv® Adapt Variable Height Secondary Clarifier Inlet At Hrsd Nansemond Treatment Plant, Matthew Poe

Civil & Environmental Engineering Theses & Dissertations

The Hampton Roads Sanitation District (HRSD) recently completed the first North American and center driven installation of the Hydrograv® Adapt Variable Height Secondary Clarifier Inlet (Adapt) at HRSD’s Nansemond Treatment Plant. This is a variable height inlet structure designed to decrease clarifier effluent turbidity and maintain low turbidity during high flow events. Low turbidity is achieved by feeding the secondary clarifier influent within the solids blanket during dry weather conditions and lifting the inlet structure during wet weather conditions to avoid disrupting the blanket. The Adapt clarifier was monitored alongside an identical fixed inlet clarifier to assess performance. Both clarifiers …

Space Charge Effects In Low Energy Magnetized Electron Beams, W. M. Sajini Anushika Kumari Wijethunga

Physics Theses & Dissertations

Magnetized electron cooling of the ion beam is one of the major approaches towards obtaining the required high luminosity in the proposed Electron-Ion Collider (EIC). To increase the cooling efficiency, a bunched electron beam with a high bunch charge and high repetition rate is required. However, these features can combine to enhance the collective interactions, such as the space charge effect. A magnetized electron beam was successfully generated at the Thomas Jefferson National Accelerator Facility (JLab) using a compact, 300 kV DC high voltage photo-gun with an inverted insulator geometry and bi-alkali antimonide photocathode. The beam magnetization was characterized using …

A Copula Model Approach To Identify The Differential Gene Expression, Prasansha Liyanaarachchi

Mathematics & Statistics Theses & Dissertations

Deoxyribonucleic acid, more commonly known as DNA, is a complex double helix-shaped molecule present in all living organisms and hosts thousands of genes. However, only a few genes exhibit differential expression and play a vital role in a particular disease such as breast cancer. Microarray technology is one of the modern technologies developed to study these gene expressions. There are two major microarray technologies available for expression analysis: Spotted cDNA array and oligonucleotide array. The focus of our research is the statistical analysis of data that arises from the spotted cDNA microarray. Numerous models have been proposed in the literature …

The Investigations Of Nps Modulated Immunity And Immunometabolism, Brittney Leigh Ruedlinger

Biomedical Sciences Theses & Dissertations

Cancers remain in the top noncommunicable diseases responsible for premature mortality. The heterogeneity among cancers and within tumors makes treating them ever more challenging. Our misfortune for developing cures is mocked by cancer, with the lowest probability of success (PoS) through clinical trials and FDA approval. At the basic level, there are generally two broad gaps impeding cancer eradication: the unidentified shared mechanism(s) exploited by all cancers and the therapeutic approach to intervene. Nanosecond pulse stimulation (NPS) offers a unique approach since its broad impacts intersect those often hijacked by oncogenesis. Metabolic pathways, known for dysfunctions among cancers, share a …

Synthesis And Characterization Of 4,6-Protected Glucosamine Derivatives And Branched Glycoconjugates, Jonathan Bietsch

Chemistry & Biochemistry Theses & Dissertations

Low molecular weight gelators (LMWGs) are small molecules that self-assemble in appropriate solvents to form three dimensional networks that immobilize the solvent, creating a supramolecular gel. The self-assembly of LMWGs occurs through non-covalent interactions such as hydrogen bonding, aromatic interactions, donor-acceptor interactions, Van der Waals interactions, hydrophobic forces, halogen bonding, etc. Due to self-assembly occurring through reversible non-covalent interactions, supramolecular gels can undergo a gel to solution transformation. Because of this, these materials can be sensitive to external stimuli such as temperature changes, pH changes, and other stimuli that effect non-covalent interactions. This makes the synthesis of LMWG’s an appealing …

Effects Of Static And Dynamic Visuals On The Learning Of Science Concepts In The Secondary-School Classroom, Theodore Johnson

Doctoral Dissertations

The current study is grounded in the cognitive theory of multimedia learning. The investigator considered how embedding science text with visuals could affect secondary-school students' ability to retain the information they learn (rote learning) and transfer the new knowledge to an unfamiliar problem (meaningful learning). Furthermore, this study explored how the type of visuals (static versus vs. dynamic visual) and text (audio vs. print) affect science learning. The data generated was sourced from student participants in a secondary-school biology classroom. The purpose of this study was to investigate how prior knowledge and the integration of information modalities (i.e., text, audio, …

Sex Or Sexual Assault? Critical Media Literacy As A Tool For Consent Education, Riana S. Pella

Doctoral Dissertations

Most children’s exposure to media begins in infancy and increases into adulthood. Even programming produced for children is rife with sexist and racist messaging (Harris, 2018). Because of its seductive imagery, media act as a highly influential form of sex education. Problematically, media habitually portray nonconsensual behavior as sexy and consent-seeking as unsexy (Katz, 2019). Black women are routinely devalued, hypersexualized, and exoticized in movies and television (Donovan, 2007). The result of such media exposure is that young people often misunderstand what constitutes sexual assault (Edwards, 2015). Logically, when individuals do not clearly understand the differences between consensual sex and …

Understanding The African American Male Student Experience Of Being Diagnosed With Emotional Disturbance Through The Use Of Counter-Storytelling, Sara Ordaz

Doctoral Dissertations

In the U.S. educational system, it is too common to see African American males overrepresented in special education classrooms, including segregated special education settings. African American males continuously experience disproportionate representation and placement in special education, especially under the label of ED (Harry & Anderson, 1994). Twice as many African American students in the United States are receiving services for Emotional Disturbance than their White counterparts.

Students who are labeled with ED have the lowest educational outcomes as well as lower success rates in life than any other disability classification (Merrrell & Walker, 2004). The consequences of the ED label …

The Ignatian Leadership Model For Catholic Schools: Critical Spirituality Theory On Leadership Practices, Leonardus Evert Bambang Winandoko

Doctoral Dissertations

Catholic schools in Indonesia played an essential role in educating young Indonesian to serve their brothers and sisters. This study demonstrates how three Catholic schools continue the important role of educating students to serve others: St. Matteo Ricci High School, St. Robert Bellarmine High School, and St. John Berchmans High School. Utilizing a multi-case study of leadership practices, this research study examines the Ignatian Pedagogical Paradigm’s impact on school leaders who promoted religious inclusivity. The study similarly highlights the challenges in promoting religious inclusivity. This research illustrates how the school leaders infuse their spiritual values into the school community to …

Early Childhood Special Education Teachers’ Attitudes Toward Inclusion: A Qualitative Study On A School’S Transition From Segregated Classrooms To More Inclusion Classrooms, Shally Moua

Doctoral Dissertations

Inclusion has been a topic of interest in education and a great deal of research has identified teachers’ attitudes as a barrier to inclusion. Therefore, using the model of attitude (Eagly & Chaiken, 1993) and inclusive pedagogy framework (Florian & Black-Hawkins, 2012), the qualitative study aims to: (1) examine the attitudes of early childhood special education (ECSE) teachers toward inclusion as a school shift from segregated to more inclusive classrooms, (2) explore types of support they received and how that support shaped their inclusive pedagogical practices to teach in inclusive classrooms, and (3) identify barriers that impact their transition to …

The Influence Of Emotion Regulation And Neural Cognitive Control On Distress Tolerance, Alicia L. Milam

Psychology Theses & Dissertations

Tolerance of negative emotions has been associated with transdiagnostic negative mental health outcomes. Theory and research implicate emotion regulation and cognitive control as factors in tolerance of negative emotions. But their unique contributions to tolerance of negative emotions and interdependency have been unclear due to methodological limitations. This study aimed to explicate cognitive and emotional factors affecting distress tolerance in a non-clinical sample of emerging adults. Undergraduate psychology students completed self-report measures of emotion regulation ability and tolerance of negative emotions. The N2 ERP component elicited by a Go-NoGo task was also used as a neurophysiological marker of cognitive control …

A Meta-Analysis Of Three Years Of Data On Outcomes Of Therapy Groups For Inmates In The Virginia Department Of Corrections, Abie Carroll Tremblay

Counseling & Human Services Theses & Dissertations

The Virginia Department of Corrections (VADOC) is responsible for about 28,000 inmates and 66,000 probationers and parolees annually. Mental health services are often conducted through therapeutic groups, many of which are manualized and based in cognitive behavioral therapy theory. In the three years, 2017 through 2019, VADOC conducted 172 therapeutic group therapy studies, and the resulting data, in the form of t-test scores, were made available for academic research. This meta-analysis investigated whether cognitive behavioral group therapy produced superior outcomes when compared to other theoretical orientations in group therapy in VADOC, if manualized group therapy treatments produced superior outcomes when …

Undergraduate Classroom Incivility From The Faculty Perspective, Erin M. Bunton

Educational Leadership & Workforce Development Theses & Dissertations

Classroom disruption, more recently referred to as civility, changes the in-person classroom experience. This study investigated the impact of gender, race, age, and teaching experience on faculty perceptions of classroom incivility.

Faculty at a large, public institution in the Southeastern United States participated in the research for this study. Hierarchical multiple regression was used to understand the relationship between the demographic variables of the participants and their perception of classroom incivility.

Study findings yielded significant results, with positive relationships between the demographic variables and perception of classroom incivility. Limitations and implications for future research are discussed.

The Impact Of Muscular Strength On Cardiovascular Disease Risk Factors, Joel Ernest Harden

Human Movement Studies & Special Education Theses & Dissertations

The purpose of this study was to determine the associations between isokinetic leg muscular strength and cardiovascular disease (CVD) risk factor characterizations in Americans aged 50 and older. Using a publicly available dataset from the National Health and Nutrition Examination Survey (NHANES), a secondary analysis was conducted on participants (males ≥50 yrs; females ≥55 yrs; N=10,858) pooled from 1999 to 2002. CVD risk factors were determined using the American College of Sports Medicine (ACSM) cutoff values, with all nine ACSM risk factors analyzed. CVD risk factor characterization was determined by creating CVD risk factor profiles (i.e., the total number of …

Covid-19, Technology, And The Math Classroom: Changes, Obstacles, And Victories Integrating Digitally, Lauren Fifield Bellamy

Teaching & Learning Theses & Dissertations

Secondary math teachers faced new experiences and struggles this past virtual school year due to the global COVID-19 pandemic. Nine secondary math teachers from a school division in southeastern Virginia participated in this qualitative single case study. Data collection included individual semi-structured interviews and technology integration artifacts. Through a three round coding process, ten themes emerged to answer the following three research questions: 1) In terms of curriculum, teaching methods, and assessments, how did teachers describe their pedagogical change in virtual learning? 2) How do teachers perceive student performance has changed within the virtual learning space? 3) From teachers’ perspectives, …

An Analysis Of Effective Practice Strategies For The Performing Undergraduate University-Level Pianist, Elizabeth Ann Duncan

Music Theses & Dissertations

The intent of this study was to provide awareness of the trends surrounding piano practice pedagogy as determined by students either immersed in a university piano program or graduates thereof. The areas of study include a historical context of university music programs and the field of piano pedagogy, trends of imitative instruction, the importance of qualitative and quantitative practice, and the discovery of piano practice routines of collegiate pianists. This research project was approved for an IRB exemption by the Old Dominion University College of Arts and Letters.

Within this study, the subjects were either graduates of a collegiate piano …

Intention-Behavior Discrepancies For Alcohol Consumption Among College Students, Emily Kaye Junkin

Psychology Theses & Dissertations

Unplanned drinkers may experience elevated risk for drinking-related harm. Research examining unplanned drinking focuses on the unplanned nature of a drinking episode (i.e., did the student drink when no drinking was planned), yet this does not capture the importance of the unintended quantity consumed. For instance, a discrepancy between drinking intentions and actual consumption has the potential to differentially impact alcohol-related outcomes beyond what is accounted for by unplanned drinking episodes. Further, research has not investigated how college students’ unintended drinking is associated with alcohol-related consequences. Moreover, utilization of protective behavioral strategies (PBS) has been shown to decrease negative outcomes …

Estimating The Risk Of Future Plastic Marine Debris Resulting From The Urban Coastal Built Environment, Kelly C. Jones

OES Theses and Dissertations

The growing urban built environment in the coastal zone poses an unknown risk to the marine biosphere as a source of marine debris. Plastic, since its introduction in the mid- 1900s, is now used in nearly all aspects of human life. Growth in human population and urbanization in coastal zones has resulted in the accumulation of large stocks of plastic in the coastal built environment, and these stocks are still growing exponentially. The coastal zone is exposed to a number of hazards including storms, tsunamis, and sea level rise, and most of these hazards are expected to change in the …

Towards Characterizing Adversarial Opportunity And Behavior In Critical Infrastructure Network, Md Sharif Ullah

Electrical & Computer Engineering Theses & Dissertations

The growth of information and communication technology is constantly revolutionizing various domains, e.g., energy utility systems, healthcare, the internet of things, etc. This inception of widespread cyber technology enables reliability and first operability of the system, yet simultaneously imposed a risk of significant impact due to disruption of safe and secure operation. The attack surface is expanding, creating a cyber exposure gap which indicates a higher threat landscape and increased risk of compromise. Motivated by this increased threat exposure, this dissertation investigates the attack surface as a static and dynamic indicator of adversary propagation, seeking an efficient modeling paradigm to …

Application Of Optimization Techniques In Corporate Cash Management, Venkateswara Reddy Dondeti

Theses and Dissertations in Business Administration

For any individual person or firm, there is a trade-off between carrying too much or too little cash on hand to meet the day-to-day transactions demand for cash. The BAT model, named after three eminent economists, Baumol, Allais, and Tobin, is the foundation for almost all cash management models in use today. The goal of the BAT model is to minimize the total costs involving the brokerage fees and the opportunity cost of interest lost on the cash held on hand. The brokerage fees are incurred in connection with the transactions for liquidating securities and converting them into cash. The …

Integrated Processing Of Municipal Solid Waste For Maximizing Waste Reduction, Carbon Recovery And Fuel Production, Kameron J. King

Civil & Environmental Engineering Theses & Dissertations

Nationally and internationally, waste generation is increasing and along with it negative environmental impacts. Many people think waste ends at disposal; however, environmental impacts have already begun. Unfortunately, 50% of waste ends up in a landfill which is the third largest source of human related methane emissions and a leading cause of global climate change. This study investigated a novel waste management strategy in hopes of mitigating negative environmental effects caused by conventional waste management practices. The novelty of the study lies in the development of an integrated method of hydrothermal carbonization and an anaerobic digestion (HTC + AD) process …

Genetically Engineered Thermosynechococcus Elongatus Bp1: Assessment Of Potential Biorisks And Biofuel Production, Thu Ho Anh Nguyen-Jones

Chemistry & Biochemistry Theses & Dissertations

According to the International Energy Outlook 2019, released by the U.S. Energy Information Administration, it is projected that the energy consumption will increase up to 50% between 2018 and 2050 worldwide. As fossil fuel being a finite source of energy with the risk of depletion, many countries are now facing an energy security crisis. Therefore, it is important to develop other renewable and sustainable energy sources that will allow countries to shift away from depending on fossil fuels. Among several types of renewable energy, biofuel production using genetically engineered cyanobacteria is capturing much interest due to its many advantages. Different …

Lean Application: An Assessment Of 5s On Employee Attitudes And Productivity, Nickolaos Dimitrios Karvounis

STEMPS Theses & Dissertations

This study examines the effect of the implementation of 5S on employee attitudes and productivity in an Asian based facility of a global manufacturing company. Utilizing an assessment of the 5S implementation in various areas of the facility and organizational performance data for each of those areas, a non-experimental, causal comparative approach is used to analyze the impact. The study concluded that statistically significant improvements from the implementation of 5S were found both in quality and product cost for this facility; however, the study also found statistical significance where the implementation of 5S led to a decrease in performance and …

Making It To The Next Grade: How Elementary School Principals Make Sense Of Grade Retention Policies For English Learners, Lynmara Colón

Educational Leadership & Workforce Development Theses & Dissertations

Critical approaches to policy suggest that policy, even in the most apparently democratic polity or institution, codifies and extends the interests of those who disproportionately wield power (Levinson et al., 2009). While many people are involved in conversations and decisionmaking processes related to the implementation of grade retention or promotion policies, the final decision is made at the school level. Critics of grade retention, meanwhile, also warn that retained students may be harmed by stigmatization, reduced expectations for their academic performance on the part of teachers and parents, and the challenges of adjusting to a new peer group (Schwerdt et …