Digital Commons Network^™

Antibody-Drug Nanoparticle Induces Synergistic Treatment Efficacies In Her2 Positive Breast Cancer Cells, Muhammad Raisul Abedin, Kaitlyne Powers, Rachel Aiardo, Dibbya Barua, Sutapa Barua

Chemical and Biochemical Engineering Faculty Research & Creative Works

Chemotherapeutic drugs suffer from non-specific binding, undesired toxicity, and poor blood circulation which contribute to poor therapeutic efficacy. In this study, antibody–drug nanoparticles (ADNs) are engineered by synthesizing pure anti-cancer drug nanorods (NRs) in the core of nanoparticles with a therapeutic monoclonal antibody, Trastuzumab on the surface of NRs for specific targeting and synergistic treatments of human epidermal growth factor receptor 2 (HER2) positive breast cancer cells. ADNs were designed by first synthesizing ~ 95 nm diameter × ~ 500 nm long paclitaxel (PTX) NRs using the nanoprecipitation method. The surface of PTXNRs was functionalized at 2′ OH nucleophilic site …

Pre-Exposure Prophylaxis With Various Doses Of Hydroxychloroquine Among Healthcare Personnel With High-Risk Exposure To Covid-19: A Randomized Controlled Trial, Fibhaa Syed, Muhammad Hassan, Mohammad Ali Arif, Sadia Batool, Rauf Niazi, Ume E Laila, Sadia Ashraf, Junaid Arshad

Faculty, Staff and Student Publications

Objective This trial aimed to evaluate the safety and efficacy of pre-exposure prophylaxis (PrEP) with various hydroxychloroquine (HCQ) doses against a placebo among healthcare personnel (HCP) with high-risk exposure to coronavirus disease 2019 (COVID 19). Methods A phase II, randomized, placebo-controlled trial was conducted including 200 subjects with no active or past severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (antibody testing and reverse transcription-polymerase chain reaction (RT-PCR) were taken at the time of enrollment). Subjects of experimental groups one to three received HCQ in various doses and the control group received a placebo. The study outcomes in terms of …

Resistin Levels Decrease As Insulin Resistance Increases In A Mexican-American Cohort, Absalon D Gutierrez, Carlos A Flores, Sapna Naik, Minjae Lee, Parisa Asgarisabet, Masha Resman, Miryoung Lee, Joseph B Mccormick, Susan P Fisher-Hoch

Faculty, Staff and Student Publications

AIMS: Links between resistin, insulin resistance (IR), and resistin-stimulated cytokine signaling remain unknown in Mexican-Americans. A Mexican-American cohort was examined to determine (1) relationships between circulating resistin and IR, (2) resistin's associations with cytokines and demographic and anthropometric variables, and (3) similar measurements with other adipokines.

METHODS: For cross sectional analyses, 953 adults (367 males and 586 females) in the Cameron County Hispanic Cohort (CCHC) were stratified into three groups: normal glucose tolerance, prediabetes, and diabetes mellitus. Differences in resistin and other adipokine levels were examined using linear regression via unadjusted model (Model 1), model adjusted for cytokines (Model 2), …

Graduate Recital: Katherine Shindledecker, Trumpet; Lu Witzig, Piano; December 1, 2021, Katherine Shindledecker, Lu Witzig

School of Music Programs

Kemp Recital Hall

December 1, 2021

Wednesday Afternoon

5:00 p.m.

Vat Treatment Of The Financial Services: Implications For The Real Economy, Ismail Baydur, Fatih Yilmaz

Research Collection School Of Economics

Financial institutions are exempt from the value-added tax (VAT) in most countries. We develop a general equilibrium model with endogenous firm entry and a banking sector to accommodate three key distortions related to exempt treatment: (i) self-supply bias in the banking sector, (ii) under-taxation of payment services, and (iii) input distortions in the business sector and tax cascading. We calibrate our model to the average of Germany, France, and the UK data. Our results show that repealing exempt treatment always increases tax revenues. However, welfare gains occur only at low VAT rates due to the hump-shaped VAT Laffer curve.

The Transformative Power Of The 2030 U.N. Sustainable Development Goals, Anna Wasescha, Christa Otteson, Sarah Casey

The Foundation Review

West Central Initiative, a mostly rural community foundation and regional development organization in Minnesota, integrated the United Nations 17 Sustainable Development Goals into its strategic plan in 2019. This article explores how aligning the U.N. goals with the foundation’s “nested strategy” of local, regional, and global goals has aligned and energized the disparate functions of the organization.

This article describes the strategic planning process that led to adoption of the goals, articulates how they have helped evolve the interplay of economic development and philanthropy, and identifies lessons learned from the first two years of working with the goals.

Focusing on …

Reconfigurable Antennas & Matching Networks For Cubesats, Marios Patriotis

Electrical and Computer Engineering ETDs

Telecommunication has rapidly evolved in the past decades, quickly becoming one of the most expansive industries, especially with the presence of new attractive eras like 5Gnetworks, automotive radars, and CubeSats. The use of miniaturized satellites such as CubeSats for cheaper and wider communication coverage has opened the possibilities for cluster satellite communication. These units exist in a continuously varying environment as much physical as electromagnetic. Hence, the establishment of a successful communication link among the space units but also ground stations becomes challenging. This new situation can be confronted with the installation of new reconfigurable antennas. These are emitting units …

The Bose-Einstein Condensate And Cold Atom Laboratory, Kai Frye, Sven Abend, Wolfgang Bartosch, Ahmad Bawamia, Dennis Becker, Holger Blume, Claus Braxmaier, Sheng Wey Chiow, Maxim A. Efremov, Wolfgang Ertmer, Peter Fierlinger, Tobias Franz, Naceur Gaaloul, Jens Grosse, Christoph Grzeschik, Ortwin Hellmig, Victoria A. Henderson, Waldemar Herr, Ulf Israelsson, James Kohel, Markus Krutzik, Christian Kürbis, Claus Lämmerzahl, Meike List, Daniel Lüdtke, Nathan Lundblad, J. Pierre Marburger, Matthias Meister, Moritz Mihm, Holger Müller, Hauke Müntinga

All Faculty Scholarship

© 2020, The Author(s). Microgravity eases several constraints limiting experiments with ultracold and condensed atoms on ground. It enables extended times of flight without suspension and eliminates the gravitational sag for trapped atoms. These advantages motivated numerous initiatives to adapt and operate experimental setups on microgravity platforms. We describe the design of the payload, motivations for design choices, and capabilities of the Bose-Einstein Condensate and Cold Atom Laboratory (BECCAL), a NASA-DLR collaboration. BECCAL builds on the heritage of previous devices operated in microgravity, features rubidium and potassium, multiple options for magnetic and optical trapping, different methods for coherent manipulation, and …

Thermodynamics In Expanding Shell-Shaped Bose-Einstein Condensates, Brendan Rhyno, Nathan Lundblad, David C. Aveline, Courtney Lannert, Smitha Vishveshwara

All Faculty Scholarship

Inspired by investigations of Bose-Einstein condensates (BECs) produced in the Cold Atom Laboratory (CAL) aboard the International Space Station, we present a study of thermodynamic properties of shell-shaped BECs. Within the context of a spherically symmetric "bubble trap"potential, we study the evolution of the system from small filled spheres to hollow, large, thin shells via the tuning of trap parameters. We analyze the bubble trap spectrum and states and track the distinct changes in spectra between radial and angular modes across the evolution. This separation of the excitation spectrum provides a basis for quantifying dimensional crossover to quasi-2D physics at …

Eye-Transcriptome And Genome-Wide Sequencing For Scolecophidia: Implications For Inferring The Visual System Of The Ancestral Snake, David J. Gower, James F. Fleming, Davide Pisani, Freek J. Vonk, Harald M.I. Kerkkamp, Leo Peichl, Sonja Meimann, Nicholas R. Casewell, Christiaan V. Henkel, Michael K. Richardson, Kate L. Sanders, Bruno F. Simões

More Faculty of Science and Engineering Research

Molecular genetic data have recently been incorporated in attempts to reconstruct the ecology of the ancestral snake, though this has been limited by a paucity of data for one of the two main extant snake taxa, the highly fossorial Scolecophidia. Here we present and analyze vision genes from the first eye-transcriptomic and genome-wide data for Scolecophidia, for Anilios bicolor, and A. bituberculatus, respectively. We also present immunohistochemistry data for retinal anatomy and visual opsin-gene expression in Anilios. Analyzed in the context of 19 lepidosaurian genomes and 12 eye transcriptomes, the new genome-wide and transcriptomic data provide evidence for a much …

Current Status And Natural History Of The Critically Endangered Variable Harlequin Toad (Atelopus Varius) In Costa Rica, C Barrio-Amorós, G Chaves, R Puschendorf

School of Biological and Marine Sciences

No abstract provided.

Authors' Responses To Peer Review Of “Influence Of The Covid-19 Lockdown On The Physical And Psychosocial Well-Being And Work Productivity Of Remote Workers: Cross-Sectional Correlational Study”, Yessica Abigail Tronco Hernández, Fabio Parente, Mark A Faghy, Clare M P Roscoe, Frances A Maratos

School of Health Professions

No abstract provided.

Pitfalls In Bootstrapping Spurious Regression, Peter C. B. Phillips

Research Collection School Of Economics

The bootstrap is shown to be inconsistent in spurious regression. The failure of the bootstrap is spectacular in that the bootstrap effectively turns a spurious regression into a cointegrating regression. In particular, the serial correlation coefficient of the residuals in the bootstrap regression does not converge to unity, so the bootstrap is not even first order consistent. The block bootstrap serial correlation coefficient does converge to unity and is therefore first order consistent, but has a slower rate of convergence and a different limit distribution from that of the sample data serial correlation coefficient. The analysis covers spurious regressions involving …

Follow The Smoke: The Pollution Haven Effect On Global Sourcing, Heather Berry, Aseem Kaul, Narae Lee

Research Collection Lee Kong Chian School Of Business

Research abstract: We examine whether and how foreign environmental standards influence global sourcing decisions. Taking a question-driven approach, we find a negative association between the stringency of a country's environmental standards and its share in US imports for 82 manufacturing industries across 77 countries between 2006 and 2016. This pollution haven effect holds not only for sourcing from owned foreign operations (offshore integration), but also for sourcing from unrelated third parties abroad (offshore outsourcing), and is stronger in industries with high toxic emissions and low technological intensity. These results are robust across alternative measures of environmental stringency and to using …

Tapping On Growth Opportunities Through Trade And Investment, Andy Feng, Gerald Foong, Geraldine Lim

Research Collection School Of Economics

As a small and open economy, external developments play a crucial role in shaping Singapore’s growth prospects. In particular, external demand is pivotal in supporting the growth of Singapore’s gross domestic product (GDP) beyond the limits afforded by a small domestic market. Furthermore, due to the resource constraints faced by Singapore, its production of goods and services to meet both external and domestic demand requires a substantial use of imported inputs. Apart from trade, Singapore’s openness and outward-orientation also extend to its embrace of inward and outward investments to grow its economy and create jobs for Singaporeans. In view of …

Economic Forecasting In An Epidemic: A Break From The Past?, Hwee Kwan Chow, Keen Meng Choy

Research Collection School Of Economics

This paper aims to investigate whether the predictive ability and behaviour of professional forecasters are different during the Covid-19 epidemic as compared with the global financial crisis of 2008 and normal times. To this end, we utilise a survey of professional forecasters in Singapore collated by the central bank to analyse the forecasting record for GDP growth and CPI inflation. We first examine the point forecasts to document the extent of forecast failure in the pandemic crisis and test for behavioural explanations of the possible sources of forecast errors such as leader following and herding behaviour. Using percentile-based summary measures …

Harnessing Digitalization For Sustainable Economic Development: Insights For Asia, John Beirne, David Fernandez

Research Collection Lee Kong Chian School Of Business

Digitalization has helped to transform economies by enhancing competitiveness and productivity across a wide range of sectors. The use of big data and the rise of online platforms have accelerated this process over the past decade. In addition, the adoption of digital solutions in the face of social distancing and lockdown measures introduced due to the coronavirus disease 2019 (COVID-19) pandemic has been integral to the economic recovery process. The shift to a digitalized economy has also reduced barriers to market entry for firms, lowered inequality, and led to a promotion of social and economic inclusion. Advances in digital technology …

Modeling The Spatial Distribution Of The Current And Future Ecosystem Services Of Urban Tree Planting In Chicopee And Fall River, Massachusetts, R. Moody, N. Geron, M. Healy, J. Rogan, Deborah Martin

Geography

Mature urban tree canopy cover disrupts the local effects of urban heat islands and provides important ecosystem services such as energy savings through evaporation and shading, pollution removal, storm runoff control, and carbon sequestration. Sustainable urban tree canopy relies on the planting of juvenile trees. Typically, tree planting programs are only evaluated by the number of trees planted and there is a lack of analysis of juvenile trees post-planting. This study examines the value and distribution of energy savings provided by juvenile trees and how that value changes considering predicted tree growth and mortality by 2050. Using i-Tree Eco software, …

Physical Properties Of Massive Compact Starburst Galaxies With Extreme Outflows, Serena Perrotta, Erin R. George, Alison L. Coil, Christy A. Tremonti, David S.N. Rupke, Julie D. Davis, Aleksandar M. Diamond-Stanic, James E. Geach, Ryan C. Hickox, John Moustakas, Grayson C. Petter, Gregory H. Rudnick, Paul H. Sell, Cameren N. Swiggum, Kelly E. Whalen

All Faculty Scholarship

We present results on the nature of extreme ejective feedback episodes and the physical conditions of a population of massive (M * ∼ 1011 M ⊙), compact starburst galaxies at z = 0.4–0.7. We use data from Keck/NIRSPEC, SDSS, Gemini/GMOS, MMT, and Magellan/MagE to measure rest-frame optical and near-IR spectra of 14 starburst galaxies with extremely high star formation rate surface densities (mean ΣSFR ∼ 2000 M ⊙ yr−1 kpc−2) and powerful galactic outflows (maximum speeds v 98 ∼ 1000–3000 km s−1). Our unique data set includes an ensemble of both emission ([O ii] λλ3726,3729, Hβ, [O iii] λλ4959,5007, Hα, …

Nest Sanitation Behavior Does Not Increase The Likelihood Of Parasitic Egg Rejection In Herring Gulls, James B. Stratton, Donald C. Dearborn

All Faculty Scholarship

Birds’ behavioral response to brood parasitism can be influenced not only by evolution but also by context and individual experience. This could include nest sanitation, in which birds remove debris from their nests. Ultimately, nest sanitation behavior might be an evolutionary precursor to the rejection of parasitic eggs. Proximately, the context or experience of performing nest sanitation behavior might increase the detection or prime the removal of parasitic eggs, but evidence to date is limited. We tested incubation-stage nests of herring gulls Larus argentatus to ask whether nest sanitation increased parasitic egg rejection. In an initial set of 160 single-object …

December 2021 Report: Examining The Continued Impact Of The Pandemic On Student Achievement In Gvsu Charter Schools, Kiel Mcqueen, Grand Valley State University

Charter School Research Reports

In March 2021, Basis Policy Research (Basis) released a report examining the impact of COVID-19 pandemic-related school closures on student achievement in Grand Valley State University (GVSU) charter schools. Findings revealed adverse effects from the pandemic were concentrated in math; achievement in fall 2020 was between 2 to 12 percentile points lower than the previous fall, with differences in math achievement greater in grades three through five. Basis researchers also found that students made gains in both math and reading; however, math growth was lower since the onset of the pandemic as compared to a typical year.

This report continues …

Gut Bacteria Are Essential For Normal Cuticle Development In Herbivorous Turtle Ants, Christophe Duplais, Vincent Sarou-Kanian, Dominique Massiot, Alia Hassan, John T. Wertz

University Faculty Publications and Creative Works

Across the evolutionary history of insects, the shift from nitrogen-rich carnivore/omnivore diets to nitrogen-poor herbivorous diets was made possible through symbiosis with microbes. The herbivorous turtle ants Cephalotes possess a conserved gut microbiome which enriches the nutrient composition by recycling nitrogen-rich metabolic waste to increase the production of amino acids. This enrichment is assumed to benefit the host, but we do not know to what extent. To gain insights into nitrogen assimilation in the ant cuticle we use gut bacterial manipulation, 15N isotopic enrichment, isotope-ratio mass spectrometry, and 15N nuclear magnetic resonance spectroscopy to demonstrate that gut bacteria contribute to …

Through Critique And Beyond: Speculative Fiction As A Tool Of Critical Pedagogy, Syd Thorne

Master's Projects and Capstones

This field projects centers around the issue of hopelessness among teachers and students and examines the genre of speculative fiction as a potential tool for cultivating critical hope in the classroom and as an asset to critical pedagogy. Utopian pedagogy and critical pedagogy make up the theoretical framework of this research and project development. The research explores the use of speculative fiction in three areas: activism and identity, student engagement, and utopian performance. The review of the literature demonstrates that the use of speculative fiction in the classroom has the potential to engage students in conversations about social justice and …

Reactive Granulomatous Dermatitis Associated With Ovarian Cancer And A Review Of Its Role As A Harbinger For Malignancy, Alexander Sherban, Jisun Cha, Elizabeth Jones

Department of Dermatology and Cutaneous Biology Faculty Papers

Reactive granulomatous dermatitis (RGD) is a rare dermatosis with a variety of cutaneous manifestations unified by a dermal granulomatous infiltrate on histology. Rheumatoid arthritis and autoimmune disease are classic associations, but an increasing number of cases have been attributed to covert malignancy. Only 41 cases of paraneoplastic RGD have been documented to our knowledge and we present an additional case that manifested eight months prior to the diagnosis of ovarian cancer and clinically mimicked morphea. Histopathologic examination identifying palisaded CD68+ cells and collagen degeneration are helpful in diagnosing this entity which may mimic a host of other cutaneous processes, including …

A Randomized Controlled Trial Of Self-Management For People With Epilepsy And A History Of Negative Health Events (Smart) Targeting Rural And Underserved People With Epilepsy: A Methodologic Report, Farren Briggs, Kristin Cassidy, Carol Blixen, Martha Sajatovic

Faculty Scholarship

Background: Many people living with epilepsy (PLWE) reside in rural communities, and epilepsy self-management may help address some of the gaps in epilepsy care for these communities. A prior randomized control trial of a remotely delivered, Web-based group format 12-week self-management program (SMART) conducted in Northeast Ohio, a primarily urban and suburban community, demonstrated improved outcomes in negative health events such as depression symptoms and quality of life. However, there is a paucity of research addressing the needs of PLWE in rural settings. Methods: The present study leverages collaboration between investigators from 2 mid-western US states (Ohio and Iowa) to …

Does Precise Case Disclosure Limit Precautionary Behavior? Evidence From Covid-19 In Singapore, Aljoscha Janssen, Matthew H. Shapiro

Research Collection School Of Economics

Limiting the spread of contagious diseases can involve both government-managed and voluntary efforts. Governments have a number of policy options beyond direct intervention that can shape individuals’ responses to a pandemic and its associated costs. During its first wave of COVID-19 cases, Singapore was among a few countries that attempted to adjust behavior through the announcement of detailed case information. Singapore's Ministry of Health maintained and shared precise, daily information detailing local travel behavior and residences of COVID-19 cases. We use this policy along with device-level cellphone data to quantify how local and national COVID-19 case announcements trigger differential behavioral …

Economic Impact Of Targeted Government Responses To Covid-19: Evidence From The Large-Scale Cluster In Seoul, Kim, Kanghyock Koh, Jinwook Shin

Research Collection School Of Economics

We estimate the economic impact of South Korea's targeted responses to the first large-scale COVID-19 cluster in Seoul. We find that foot traffic and retail sales decreased only within a 300 meter radius of the cluster and recovered to its pre-outbreak level after four weeks. The reductions appear to be driven by temporary business closures rather than the risk avoidance behavior of the citizens. Our results imply that less intense, but more targeted COVID-19 interventions, such as pin-pointed, temporary closures of businesses, can be a low-cost alternative after lifting strict social distancing measures.

A Practical Guide To Harnessing The Har Volatility Model, Adam Clements, Daniel P. A. Preve

Research Collection School Of Economics

The standard heterogeneous autoregressive (HAR) model is perhaps the most popular benchmark model for forecasting return volatility. It is often estimated using raw realized variance (RV) and ordinary least squares (OLS). However, given the stylized facts of RV and well-known properties of OLS, this combination should be far from ideal. The aim of this paper is to investigate how the predictive accuracy of the HAR model depends on the choice of estimator, transformation, or combination scheme made by the market practitioner. In an out-of-sample study, covering the S&P 500 index and 26 frequently traded NYSE stocks, it is found that …

School District Leadership And Racial Justice: Examining The Use Of A Culturally Responsive-Sustaining Framework To Advance Equity Between Black And White Student Populations Within New York State Public Education, Diane M. Wynne

Education Doctoral

The current climate in the United States reflects a heightened focus on examining and challenging systemic inequities that have long impacted Black individuals. Culturally responsive education efforts have increased as schools experience increasingly diverse populations. The purpose of this study was to gain an understanding of how district leaders are implementing the New York State Education Department (NYSED) Culturally Responsive-Sustaining (CR-S) Education Framework in advancing equity between their Black and White student populations. Challenges and barriers experienced in the implementation of this framework, and approaches and strategies needed to overcome these were also explored. Interviews with six school district leaders …

Mathematical Modelling Of Gene Regulatory Networks, Ruaa Rifaat Al-Shykhly, Lamyaa Mohammed Hameed

Journal of Economics and Administrative Sciences

This research includes the use of an artificial intelligence algorithm, which is one of the algorithms of biological systems which is the algorithm of genetic regulatory networks (GRNs), which is a dynamic system for a group of variables representing space within time. To construct this biological system, we use (ODEs) and to analyze the stationarity of the model we use Euler's method. And through the factors that affect the process of gene expression in terms of inhibition and activation of the transcription process on DNA, we will use TF transcription factors. The current research aims to use the latest methods …