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Data-Driven Statin Initiation Evaluation And Optimization For Prediabetes Population, Muhenned A. Abdulsahib

Graduate Theses and Dissertations

This dissertation develops quantitative models to support medical decision making of statininitiation considering the uncertainty in disease progression for prediabetes patients. A mathematical model is built to help medical decision-makers take action of statin initiation under uncertainty in future prediabetes progressions. The association between cholesterol drug use, such as statin, and elevating glucose level attracted considerable amounts of attention in the literature. Statin effects on glucose vary with respect to different levels of glucose. The first chapter of this dissertation introduces the problem and an overview of the tools that will be used to solve it. In the second chapter …

Statistical Modeling, Learning And Computing For Stochastic Dynamics Of Complex Systems, Mohammadmahdi Hajiha

Graduate Theses and Dissertations

With the recent advances in sensor technology, it is much easier to collect and store streams of system operational and environmental (SOE) data. These data can be used as input to model the underlying behavior of complex engineered systems and phenomenons if appropriate algorithms with well-defined assumptions are developed. This dissertation is comprised of the research work to show the applicability of SOE data when fed into proposed tailored algorithms. The first purposes of these algorithms are to estimate and analyze the reliability of a system as elaborated in Chapter 2. This chapter provides the derivation of closed-form expressions that …

Can Minimally Invasive Surgery Still Be Done For Cervical Cancer Patients Considering The Lacc Trial?, Sichen Liang, Zhiqing Liang, Samar Nahas, Jianming Song, Zeyi Cao, Adel Shervin, Bruno J. Van Herendael, Jennifer Song, Jianliu Wang

Student Publications

No abstract provided.

Is Surgery Essential For Management Of High Grade Neuroendocrine Carcinoma Of The Breast? A Case Report And Review, Dakota Sudbeck, Boban N. Mathew

Student Publications

High grade neuroendocrine carcinoma of the breast (HGNCB) is an aggressive and rare primary breast malignancy. No standard management recommendations exist for this entity and they are managed similarly as traditional breast cancers. Here we present the first case of a 54 year old female with high grade neuroendocrine carcinoma of the breast managed non-surgically with concurrent chemoradiation. At the time of this publication, she is more than 8 years from diagnosis without evidence of recurrence.

Metastatic Castrate-Resistant Prostate Cancer: A Rare Cause Of Bowel Obstruction, Syed Ehsanullah, Syeda Zarmeena Rashid, Saiyed Abdullah A. Ehsanullah

2020-Current year OA Pubs

Prostate cancer most commonly metastasizes to bone, lymph nodes, lungs, or liver, but rarely spreads to the large intestine. This case highlights a rare case of castrate-resistant prostate cancer (CRPC) that spread locally to the large intestine and rectum, significant enough to cause bowel obstruction. Metastatic prostate carcinomas are considered an infrequent cause of bowel obstruction.

Single-Cell Rna-Sequencing Analysis Of The Ciliary Epithelium And Contiguous Tissues In The Mouse Eye, J C Youkilis, S Bassnett

2020-Current year OA Pubs

The ciliary epithelium plays a central role in ocular homeostasis but cells of the pigmented and non-pigmented layers are difficult to isolate physically and study. Here we used single-cell RNA-sequencing (scRNA-seq) to analyze the transcriptional signatures of cells harvested from the ciliary body and contiguous tissues. Microdissected tissue was dissociated by collagenase digestion and the transcriptomes of individual cells were obtained using a droplet-based scRNA-seq approach. In situ hybridization was used to verify the expression patterns of selected differentially-expressed genes. High quality transcriptomes were obtained from 10,024 cells and unsupervised clustering distinguished 22 cell types. Although efforts were made to …

Analysis Of Nipple-Areola Complex Localization Using Male Cadavers: Considerations For Gender-Affirming Surgery, Amanda K. Moorefield, Anna Stock, Zak Rose-Reneau, Pratima Singh, Zubeen Azari, Barth Wright, Virender Singhal

Faculty and Staff Publications

Background:

Masculinizing chest reconstruction is the most common gender-affirming surgery in transgender males. Despite the current literature’s acknowledgment of the vital role that proper placement of the nipple-areola complex (NAC) plays in a masculine chest contour, there is still much debate regarding the best anatomical landmarks to achieve the desired result.

Objectives:

The primary aim of this study is to determine which landmarks for NAC placement can be applied across diverse body types and aid surgeons in creating a masculine chest.

Methods:

Twenty-five formaldehyde-embalmed male cadavers were analyzed by conducting various measurements of the NAC, nipple, and surrounding bony and …

Semiflexible Oligomers Crystallize Via A Cooperative Phase Transition, Pierre Kawak, Dakota S. Banks, Douglas R. Tree

Faculty Publications

Semicrystalline polymers are ubiquitous, yet despite their fundamental and industrial importance, the theory of homogeneous nucleation from a melt remains a subject of debate. A key component of the controversy is that polymer crystallization is a non-equilibrium process, making it difficult to distinguish between effects that are purely kinetic and those that arise from the underlying thermodynamics. Due to computational cost constraints, simulations of polymer crystallization typically employ non-equilibrium molecular dynamics techniques with large degrees of undercooling that further exacerbate the coupling between thermodynamics and kinetics. In a departure from this approach, in this study, we isolate the near-equilibrium nucleation …

Absence Of Coding Somatic Single Nucleotide Variants Within Well-Known Candidate Genes In Late-Onset Sporadic Alzheimer's Disease Based On The Analysis Of Multi-Omics Data, Shishi Min, Zongchang Li, Annie Shieh, Gina Giase, Ney Alliey Rodriguez

School of Medicine Publications

Somatic mutations arise randomly or are induced by environmental factors, which may increase the risk of Alzheimer's disease (AD). Identifying somatic mutations in sporadic AD (SAD) may provide new insight of the disease. To evaluate the potential contribution of somatic single nucleotide variations (SNVs), particularly that of well-known AD-candidate genes, we investigated sequencing data sets from four platforms: whole-genome sequencing (WGS), deep whole-exome sequencing (WES) on paired brain and liver samples, RNA sequencing (RNA-seq), and single-cell whole-genome sequencing (scWGS) of brain samples from 16 AD patients and 16 non-AD individuals. We found that the average number, mean variant allele fractions …

Agents Of Bioshield: The Fda, Emergency Use Authorizations, And Public Trust, Kirstiana Perryman

Georgia Law Review

The SARS-CoV-2 pandemic spurred the U.S. Food & Drug Administration (FDA) to utilize the Emergency Use Authorization (EUA) procedure more than ever before. The pandemic pushed the relatively obscure procedure into public consciousness, making it a frequent topic of discussion and debate. The EUA procedure permits the FDA Commissioner to authorize the introduction of drugs, devices, or biological products into interstate commerce for use in an actual or potential emergency. To issue an authorization, the FDA Commissioner must determine that it is “reasonable to believe,” based on the “totality of the evidence,” that the product “may be effective.” This standard …

Going, Going, Gone: Takings Clause Challenges To The Cdc’S Eviction Moratorium, Meredith Bradshaw

Georgia Law Review

In September 2020, in response to the COVID-19 pandemic, the Centers for Disease Control and Prevention (CDC) and the Department of Health and Human Services issued a residential eviction moratorium to prevent the further spread of COVID- 19. One year later, the U.S. Supreme Court terminated the moratorium. During the year that the moratorium was in effect, landlords across the country filed lawsuits against the CDC because they were unable to evict tenants who did not satisfy their rental obligations. Because the moratorium allowed tenants to remain on the property without paying rent, some landlords argued that the regulation effected …

Boom Or Bust: Ensuring The Georgia State-Wide Business Court Fulfills Its Constitutional Promise, Roya Naghepour

Georgia Law Review

The United States judiciary includes specialized court systems within its baseline civil and criminal justice structure that provide more efficient and expert adjudication in a wide variety of areas. Since the creation of the Delaware Court of Chancery in 1792, many states have established specialized business courts with jurisdiction over commercial and corporate disputes. Today, many states have business court models, all choosing to employ some version of a specialized forum for corporate and commercial issues for the sake of judicial efficiency. The Georgia State-wide Business Court was established in 2019 with limited jurisdiction over narrow categories of commercial disputes. …

The Gig Economy’S Short Reach: An Analysis Of The Scope Of The Federal Arbitration Act’S “Transportation Worker” Exemption, Emina Sadic Herzberger

Georgia Law Review

The Federal Arbitration Act (FAA) governs arbitration agreements in the United States. Section 1 of the FAA provides an exemption from arbitration for “contracts of employment of seamen, railroad employees, or any other class of workers engaged in foreign or interstate commerce.” In a 2001 decision, Circuit City Stores, Inc. v. Adams, the U.S. Supreme Court held that the residual phrase “any other class of workers engaged in foreign or interstate commerce” includes transportation workers. But, such language is ambiguous, and the Supreme Court did not expound upon what it means to be a transportation worker or to be engaged …

Habitat And Environmental Risks Of Chagas Disease In Low-Income Colonias And Peri-Urban Subdivisions In South Texas, Bára Šafářová, Cecilia H. Giusti, Maria P. Perez, Italo B. Zecca, Ester S. Carbajal, Gabriel L. Hamer, Sarah A. Hamer

School of Medicine Publications

Both the planning and public health literature have discussed proximity to greenspaces as predominantly beneficial to health, based on studies mostly conducted in high-income regions. Understanding the health risks of proximity to greenspace and nature—where pathogens and wildlife coexist—is important, as nature-based solutions are increasingly called for to address complex urban challenges. This exploratory pilot study bridges planning and epidemiology approaches to develop a new method to analyze habitat and environmental factors associated with the risk of vector-borne Chagas disease in a low-income region, South Texas. Chagas disease is endemic in Latin America, where it affects between seven to eight …

Whole-Genome Association Analyses Of Sleep-Disordered Breathing Phenotypes In The Nhlbi Topmed Program, Brian E. Cade, Brian E. Cade, Jiwon Lee, Tamar Sofer, Heming Wang, Man Zhang, Han Chen, John Blangero, Joanne E. Curran, Juan M. Peralta

School of Medicine Publications

Background: Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, we performed the first whole-genome sequence analysis of sleep-disordered breathing. Methods: The study sample was comprised of 7988 individuals of diverse ancestry. Common-variant and pathway analyses included an additional 13,257 individuals. We examined five complementary traits describing different aspects of sleep-disordered breathing: the apnea-hypopnea index, average oxyhemoglobin desaturation per event, average and minimum oxyhemoglobin saturation across the sleep episode, and the percentage of sleep with oxyhemoglobin saturation < 90%. We adjusted for age, sex, BMI, study, and family structure using MMSKAT and EMMAX mixed linear model approaches. Additional bioinformatics analyses were performed with MetaXcan, GIGSEA, and ReMap. Results: We identified a multi-ethnic set-based rare-variant association (p = 3.48 × 10−8) on chromosome X with ARMCX3. Additional rare-variant associations include ARMCX3-AS1, MRPS33, and C16orf90. Novel common-variant loci were identified in the NRG1 and SLC45A2 regions, and previously associated loci in the IL18RAP and ATP2B4 regions were associated with novel phenotypes. Transcription factor binding site enrichment identified associations with genes implicated with respiratory and craniofacial traits. Additional analyses identified significantly associated pathways. Conclusions: We have identified the first gene-based rare-variant associations with objectively measured sleep-disordered breathing traits. Our results increase the understanding of the genetic architecture of sleep-disordered breathing and highlight associations in genes that modulate lung development, inflammation, respiratory rhythmogenesis, and HIF1A-mediated hypoxic response.

Neuroimaging Association Scores: Reliability And Validity Of Aggregate Measures Of Brain Structural Features Linked To Mental Disorders In Youth, Luiza Kvitko Axelrud, André Rafael Simioni, Daniel Samuel Pine, Anderson M. Winkler, Pedro Mario Pan, João Ricardo Sato, André Zugman, Nadine Parker, Felipe Picon, Andrea Jackowski

School of Medicine Publications

In genetics, aggregation of many loci with small effect sizes into a single score improved prediction. Nevertheless, studies applying easily replicable weighted scores to neuroimaging data are lacking. Our aim was to assess the reliability and validity of the Neuroimaging Association Score (NAS), which combines information from structural brain features previously linked to mental disorders. Participants were 726 youth (aged 6–14) from two cities in Brazil who underwent MRI and psychopathology assessment at baseline and 387 at 3-year follow-up. Results were replicated in two samples: IMAGEN (n = 1627) and the Healthy Brain Network (n = 843). NAS …

Doing Philanthropy At The Time Of The Sustainable Development Goals: The Case Of Fondazione Compagnia Di San Paolo, Fulvio Bersanetti, Filippo Candela, Paolo Mulassano

The Foundation Review

This article outlines how strategic philanthropy can align its mission with the United Nations 2030 Agenda for Sustainable Development by describing the experience of the most important foundation of banking origin in Italy. Fondazione Compagnia di San Paolo marked a milestone in 2020 in aligning with the Agenda, applying the Sustainable Development Goals as a rigorous, internationally shared methodological framework and restructuring its operations to focus on three programmatic efforts — Planet, People, and Culture — aligned with those goals.

To complete our examination of this transformation, we conducted a benchmark analysis involving nine case studies of foundations in Europe …

The Effects Of Cost, Level Of Safety, And Severity Of Injury On Manager Decisions To Implement A Safety Solution, Jonathan M. Hochmuth

Dissertations

Workplace injuries continue to be a source of substantial human and financial costs each year. Behavioral safety processes have been effective in reducing workplace injuries by increasing safety-related behaviors. In recent years, the focus in behavioral safety has shifted towards the role of managers in establishing and maintaining safe behaviors and conditions in the workplace. Understanding how managers make decisions to allocate resources is critical to improving safety. The field of behavioral economics has developed methods for studying decision-making. While there have been calls to apply these methods to occupational safety, there are only two empirical studies which have done …

Informing Cognitive Screening In The Young Adult Population, Samantha L. Mcdaniel

Dissertations

The clock drawing test (CDT) is a cognitive screening measure with sound psychometric properties which has been well researched over the past century. The CDT is a popular tool for many healthcare professionals to administer independently or as part of a more thorough cognitive evaluation. Given the drastic technological and social developments over the years since the CDT was developed as well as the persistent research focus on older adult populations, a gap in the CDT literature presented for young adults, who may have difficulty drawing an analog clock. Identifying cognitive impairment can improve health outcomes. The young adult population …

In An Era Of Soft Skills: Investigating Teamwork Skills In The Geosciences, Samuel Cornelius Nyarko

Dissertations

Geoscience employers have increasingly called for student competency in three sets of skills – technical, field and soft skills. One major soft skill identified by employers is teamwork, which is critical in laboratory and field-based activities. At the same time, educators seek to inculcate in students a stronger focus on the development of teamwork skills as they are useful for knowledge sharing and problem solving. This interconnected value of teamwork in both the workforce and academia means students’ preparation should include learning teamwork in the geoscience. However, before educators can design strategies that help students learn critical teamwork skills, we …

Refugee Social Relations: The Development Of Social Ties Among Burmese And Congolese Refugees In West Michigan, Diane M. Roushangar

Dissertations

Refugee resettlement has been studied extensively in the academic realm. Yet, an area that is less understood is among Burmese and Congolese refugees and their adaptation processes in the United States. This study focuses on the development of social relations within these two groups as they navigate interactions within their ethnic group and with the native-born community. Examining the process of how social relations are constructed, this study reveals the nuances of how Burmese and Congolese form close social ties by focusing on four distinct social domains. Illuminating how social relations are formed and maintained within the ethnic community, church …

A Model For Evaluating Charitable Contributions In Nonprofit Organizations In Kalamazoo County, Michigan, Kristen Smith

Dissertations

Reported data suggest there has been an increase in charitable giving and the number of charitable organizations in communities nationwide over the last 20 years. It is widely believed that growth in nonprofit organizations would be a valuable asset for a community, but limited research evaluates the return on investment in these organizations. To ensure these organizations are good stewards of resources, various forms of accountability have been established, including websites like “Charity Navigator™,” which provide rankings and scores to charities nationwide. Data repositories like these make it possible to investigate variations in these organizations' funding, growth, and impact. This …

Essays On Bitcoin And Cryptocurrencies, Jiasong Wu

Dissertations

Bitcoin and cryptocurrencies, invented as potential digital international currencies, have gradually drawn more and more attention since their birth. The growing popularity of cryptocurrencies in the past decade and the recent acceptance of Bitcoin as legal tender in El Salvador suggests that there is growing acceptance of these instruments and that cryptocurrencies are here to stay. Among these cryptocurrencies, Bitcoin has a unique place being the first and most well-known cryptocurrency in terms of price, market capitalization, and trading volume.

The first two essays of this dissertation focus on Bitcoin and the third essay focuses on the cryptocurrency market in …

Gender Quotas And Women's Substantive Representation In The National And Local Governments Of The Dominican Republic, Marcial Amaury Pineda Moquete

Dissertations

Although women's political representation has increased during the first part of the twenty-first century, the number of female politicians in legislative assemblies worldwide remains low. When well-designed and enforced, gender quota laws can increase women's representation. In tum, the election of female politicians brings about better outcomes for women. Further, female politicians elected by quota are likely to feel more committed to representing women than counterparts elected without quotas. This study tests whether and how quota-elected women can represent women's interests better than men and women elected without quotas. Using the rare natural experiment of the Dominican Republic's Congress and …

Connected And Automated Vehicles: Their Implication On Capacity Of A Basic Freeway Section And Impacts On Walkway Safety, Sia Macmillan Lyimo

Dissertations

Autonomous vehicles have recently gained the attention of researchers due to their expected potential benefits on highway traffic streams, such as improving roadway capacity, among others. It is imperative to investigate how these expected benefits can be leveraged in the transportation sector. Understanding the safety and operational benefits helps the concerned transportation agencies and other key stakeholders to make necessary infrastructural and policy adjustments to accommodate such future traffic operation changes. The main goal of this dissertation is to study the impact of connected and automated vehicles on freeway capacity. The simulated environment was created to emulate autonomous vehicle behaviors, …

Searching For Imaging Biomarkers Of Psychotic Dysconnectivity, Amanda L. Rodrigue, Dana Mastrovito, Oscar Esteban, Joke Durnez, Marinka M. G. Koenis, Ronald Janssen, Aaron Alexander-Bloch, Emma M. Knowles, Samuel R. Mathias, John Blangero

School of Medicine Publications

Background: Progress in precision psychiatry is predicated on identifying reliable individual-level diagnostic biomarkers. For psychosis, measures of structural and functional connectivity could be promising biomarkers given consistent reports of dysconnectivity across psychotic disorders using magnetic resonance imaging.

Methods: We leveraged data from four independent cohorts of patients with psychosis and control subjects with observations from approximately 800 individuals. We used group-level analyses and two supervised machine learning algorithms (support vector machines and ridge regression) to test within-, between-, and across-sample classification performance of white matter and resting-state connectivity metrics.

Results: Although we replicated group-level differences in brain connectivity, individual-level classification …

The Impact Of Leadership And Institutional Priorities On Degree Completion Of Community College Students, Estelle L. Garza

Electronic Theses and Dissertations

This study explored student perceptions of leadership and the impact they believed it to have on their ability to complete a degree at a community college district. Community college degree completion is both a statewide and national problem as most students who start a degree program will drop out before reaching the requirements to finish their degree, which can hurt their career opportunities and the economy. The purpose of this study was to determine how students perceive factors like leadership and their satisfaction with institutional priority factors to impact degree completion. This study used action research and a mixed methods …

Part-Time Enrolled Community College Students: A Case Study Examining The Experiences Of The Invisible Majority, Janelle M. Green

Electronic Theses and Dissertations

This qualitative research used multiple case study methodology to explore the perceptions and experiences of part-time enrolled students at multicampus urban community colleges in the Southwest region of the United States. Of particular interest was how students defined success and their perception of what it took to achieve success, the utilization rate of student success resources, challenges encountered that caused a student to consider stopping out, the quality of relationships and connections part-time students had with faculty and staff, and the experience students had navigating institutional systems and processes. This study was conducted at a large, public, urban, multicampus community …

Youth Leadership Development Programs: Participants’ Pre- And Post-Perceptions Of Leadership Life Skills Development, Courtney A. Pruner

Electronic Theses and Dissertations

Research exists on the participation of youth in various types of youth leadership development programs. However, the problem is a lack of understanding of the perception of participants’ pre- and postparticipation on their development of leadership life skills. The purpose of this quantitative, causal-comparative study was to determine how youth leadership development program participants perceive themselves in the area of leadership life skills development pre- and postparticipation in a youth leadership development program. In this study, specific consideration was given to the difference in gender and ethnic minority affiliation reporting scores. The independent variables in this study were participation in …

Mechanisms And Applications Of Improved Protein Analysis By Desorption Electrospray Ionization Mass Spectrometry (Desi-Ms), Roshan Javanshad

Dissertations

Electrospray ionization mass spectrometry (ESI-MS) is a soft ionization technique that allows detection of macromolecules, such as intact proteins, by the formation of multiply charged ions from solutions. Desorption electrospray ionization mass spectrometry (DESI-MS) is an ambient ionization technique that directly samples analyte from a surface during ESI-MS analysis. Although DESI-MS is highly accomplished at the analyses of metabolites, lipids, and other small molecules, it is far more limited when it comes to protein analysis. While most of the field in ambient ionization MS has moved towards primarily applications, our approach has been to explore the use of DESI-MS and …