Digital Commons Network^™

Boom Or Bust: Ensuring The Georgia State-Wide Business Court Fulfills Its Constitutional Promise, Roya Naghepour

Georgia Law Review

The United States judiciary includes specialized court systems within its baseline civil and criminal justice structure that provide more efficient and expert adjudication in a wide variety of areas. Since the creation of the Delaware Court of Chancery in 1792, many states have established specialized business courts with jurisdiction over commercial and corporate disputes. Today, many states have business court models, all choosing to employ some version of a specialized forum for corporate and commercial issues for the sake of judicial efficiency. The Georgia State-wide Business Court was established in 2019 with limited jurisdiction over narrow categories of commercial disputes. …

The Gig Economy’S Short Reach: An Analysis Of The Scope Of The Federal Arbitration Act’S “Transportation Worker” Exemption, Emina Sadic Herzberger

Georgia Law Review

The Federal Arbitration Act (FAA) governs arbitration agreements in the United States. Section 1 of the FAA provides an exemption from arbitration for “contracts of employment of seamen, railroad employees, or any other class of workers engaged in foreign or interstate commerce.” In a 2001 decision, Circuit City Stores, Inc. v. Adams, the U.S. Supreme Court held that the residual phrase “any other class of workers engaged in foreign or interstate commerce” includes transportation workers. But, such language is ambiguous, and the Supreme Court did not expound upon what it means to be a transportation worker or to be engaged …

Habitat And Environmental Risks Of Chagas Disease In Low-Income Colonias And Peri-Urban Subdivisions In South Texas, Bára Šafářová, Cecilia H. Giusti, Maria P. Perez, Italo B. Zecca, Ester S. Carbajal, Gabriel L. Hamer, Sarah A. Hamer

School of Medicine Publications

Both the planning and public health literature have discussed proximity to greenspaces as predominantly beneficial to health, based on studies mostly conducted in high-income regions. Understanding the health risks of proximity to greenspace and nature—where pathogens and wildlife coexist—is important, as nature-based solutions are increasingly called for to address complex urban challenges. This exploratory pilot study bridges planning and epidemiology approaches to develop a new method to analyze habitat and environmental factors associated with the risk of vector-borne Chagas disease in a low-income region, South Texas. Chagas disease is endemic in Latin America, where it affects between seven to eight …

Whole-Genome Association Analyses Of Sleep-Disordered Breathing Phenotypes In The Nhlbi Topmed Program, Brian E. Cade, Brian E. Cade, Jiwon Lee, Tamar Sofer, Heming Wang, Man Zhang, Han Chen, John Blangero, Joanne E. Curran, Juan M. Peralta

School of Medicine Publications

Background: Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, we performed the first whole-genome sequence analysis of sleep-disordered breathing. Methods: The study sample was comprised of 7988 individuals of diverse ancestry. Common-variant and pathway analyses included an additional 13,257 individuals. We examined five complementary traits describing different aspects of sleep-disordered breathing: the apnea-hypopnea index, average oxyhemoglobin desaturation per event, average and minimum oxyhemoglobin saturation across the sleep episode, and the percentage of sleep with oxyhemoglobin saturation < 90%. We adjusted for age, sex, BMI, study, and family structure using MMSKAT and EMMAX mixed linear model approaches. Additional bioinformatics analyses were performed with MetaXcan, GIGSEA, and ReMap. Results: We identified a multi-ethnic set-based rare-variant association (p = 3.48 × 10−8) on chromosome X with ARMCX3. Additional rare-variant associations include ARMCX3-AS1, MRPS33, and C16orf90. Novel common-variant loci were identified in the NRG1 and SLC45A2 regions, and previously associated loci in the IL18RAP and ATP2B4 regions were associated with novel phenotypes. Transcription factor binding site enrichment identified associations with genes implicated with respiratory and craniofacial traits. Additional analyses identified significantly associated pathways. Conclusions: We have identified the first gene-based rare-variant associations with objectively measured sleep-disordered breathing traits. Our results increase the understanding of the genetic architecture of sleep-disordered breathing and highlight associations in genes that modulate lung development, inflammation, respiratory rhythmogenesis, and HIF1A-mediated hypoxic response.

Neuroimaging Association Scores: Reliability And Validity Of Aggregate Measures Of Brain Structural Features Linked To Mental Disorders In Youth, Luiza Kvitko Axelrud, André Rafael Simioni, Daniel Samuel Pine, Anderson M. Winkler, Pedro Mario Pan, João Ricardo Sato, André Zugman, Nadine Parker, Felipe Picon, Andrea Jackowski

School of Medicine Publications

In genetics, aggregation of many loci with small effect sizes into a single score improved prediction. Nevertheless, studies applying easily replicable weighted scores to neuroimaging data are lacking. Our aim was to assess the reliability and validity of the Neuroimaging Association Score (NAS), which combines information from structural brain features previously linked to mental disorders. Participants were 726 youth (aged 6–14) from two cities in Brazil who underwent MRI and psychopathology assessment at baseline and 387 at 3-year follow-up. Results were replicated in two samples: IMAGEN (n = 1627) and the Healthy Brain Network (n = 843). NAS …

Reassessing Associations Between White Matter And Behaviour With Multimodal Microstructural Imaging, Alberto Lazari, Piergiorgio Salvan, Michiel Cottaar, Daniel Papp, Olof Jens Van Der Werf, Ainslie Johnstone, Zeena-Britt Sanders, Cassandra Sampaio-Baptista, Nicole Eichert, Anderson M. Winkler

School of Medicine Publications

Several studies have established specific relationships between White Matter (WM) and behaviour. However, these studies have typically focussed on fractional anisotropy (FA), a neuroimaging metric that is sensitive to multiple tissue properties, making it difficult to identify what biological aspects of WM may drive such relationships. Here, we carry out a pre-registered assessment of WM-behaviour relationships in 50 healthy individuals across multiple behavioural and anatomical domains, and complementing FA with myelin-sensitive quantitative MR modalities (MT, R1, R2∗).

Surprisingly, we only find support for predicted relationships between FA and behaviour in one of three pre-registered tests. For one behavioural domain, …

Doing Philanthropy At The Time Of The Sustainable Development Goals: The Case Of Fondazione Compagnia Di San Paolo, Fulvio Bersanetti, Filippo Candela, Paolo Mulassano

The Foundation Review

This article outlines how strategic philanthropy can align its mission with the United Nations 2030 Agenda for Sustainable Development by describing the experience of the most important foundation of banking origin in Italy. Fondazione Compagnia di San Paolo marked a milestone in 2020 in aligning with the Agenda, applying the Sustainable Development Goals as a rigorous, internationally shared methodological framework and restructuring its operations to focus on three programmatic efforts — Planet, People, and Culture — aligned with those goals.

To complete our examination of this transformation, we conducted a benchmark analysis involving nine case studies of foundations in Europe …

The Effects Of Cost, Level Of Safety, And Severity Of Injury On Manager Decisions To Implement A Safety Solution, Jonathan M. Hochmuth

Dissertations

Workplace injuries continue to be a source of substantial human and financial costs each year. Behavioral safety processes have been effective in reducing workplace injuries by increasing safety-related behaviors. In recent years, the focus in behavioral safety has shifted towards the role of managers in establishing and maintaining safe behaviors and conditions in the workplace. Understanding how managers make decisions to allocate resources is critical to improving safety. The field of behavioral economics has developed methods for studying decision-making. While there have been calls to apply these methods to occupational safety, there are only two empirical studies which have done …

Informing Cognitive Screening In The Young Adult Population, Samantha L. Mcdaniel

Dissertations

The clock drawing test (CDT) is a cognitive screening measure with sound psychometric properties which has been well researched over the past century. The CDT is a popular tool for many healthcare professionals to administer independently or as part of a more thorough cognitive evaluation. Given the drastic technological and social developments over the years since the CDT was developed as well as the persistent research focus on older adult populations, a gap in the CDT literature presented for young adults, who may have difficulty drawing an analog clock. Identifying cognitive impairment can improve health outcomes. The young adult population …

In An Era Of Soft Skills: Investigating Teamwork Skills In The Geosciences, Samuel Cornelius Nyarko

Dissertations

Geoscience employers have increasingly called for student competency in three sets of skills – technical, field and soft skills. One major soft skill identified by employers is teamwork, which is critical in laboratory and field-based activities. At the same time, educators seek to inculcate in students a stronger focus on the development of teamwork skills as they are useful for knowledge sharing and problem solving. This interconnected value of teamwork in both the workforce and academia means students’ preparation should include learning teamwork in the geoscience. However, before educators can design strategies that help students learn critical teamwork skills, we …

Refugee Social Relations: The Development Of Social Ties Among Burmese And Congolese Refugees In West Michigan, Diane M. Roushangar

Dissertations

Refugee resettlement has been studied extensively in the academic realm. Yet, an area that is less understood is among Burmese and Congolese refugees and their adaptation processes in the United States. This study focuses on the development of social relations within these two groups as they navigate interactions within their ethnic group and with the native-born community. Examining the process of how social relations are constructed, this study reveals the nuances of how Burmese and Congolese form close social ties by focusing on four distinct social domains. Illuminating how social relations are formed and maintained within the ethnic community, church …

A Model For Evaluating Charitable Contributions In Nonprofit Organizations In Kalamazoo County, Michigan, Kristen Smith

Dissertations

Reported data suggest there has been an increase in charitable giving and the number of charitable organizations in communities nationwide over the last 20 years. It is widely believed that growth in nonprofit organizations would be a valuable asset for a community, but limited research evaluates the return on investment in these organizations. To ensure these organizations are good stewards of resources, various forms of accountability have been established, including websites like “Charity Navigator™,” which provide rankings and scores to charities nationwide. Data repositories like these make it possible to investigate variations in these organizations' funding, growth, and impact. This …

Essays On Bitcoin And Cryptocurrencies, Jiasong Wu

Dissertations

Bitcoin and cryptocurrencies, invented as potential digital international currencies, have gradually drawn more and more attention since their birth. The growing popularity of cryptocurrencies in the past decade and the recent acceptance of Bitcoin as legal tender in El Salvador suggests that there is growing acceptance of these instruments and that cryptocurrencies are here to stay. Among these cryptocurrencies, Bitcoin has a unique place being the first and most well-known cryptocurrency in terms of price, market capitalization, and trading volume.

The first two essays of this dissertation focus on Bitcoin and the third essay focuses on the cryptocurrency market in …

Gender Quotas And Women's Substantive Representation In The National And Local Governments Of The Dominican Republic, Marcial Amaury Pineda Moquete

Dissertations

Although women's political representation has increased during the first part of the twenty-first century, the number of female politicians in legislative assemblies worldwide remains low. When well-designed and enforced, gender quota laws can increase women's representation. In tum, the election of female politicians brings about better outcomes for women. Further, female politicians elected by quota are likely to feel more committed to representing women than counterparts elected without quotas. This study tests whether and how quota-elected women can represent women's interests better than men and women elected without quotas. Using the rare natural experiment of the Dominican Republic's Congress and …

Connected And Automated Vehicles: Their Implication On Capacity Of A Basic Freeway Section And Impacts On Walkway Safety, Sia Macmillan Lyimo

Dissertations

Autonomous vehicles have recently gained the attention of researchers due to their expected potential benefits on highway traffic streams, such as improving roadway capacity, among others. It is imperative to investigate how these expected benefits can be leveraged in the transportation sector. Understanding the safety and operational benefits helps the concerned transportation agencies and other key stakeholders to make necessary infrastructural and policy adjustments to accommodate such future traffic operation changes. The main goal of this dissertation is to study the impact of connected and automated vehicles on freeway capacity. The simulated environment was created to emulate autonomous vehicle behaviors, …

Searching For Imaging Biomarkers Of Psychotic Dysconnectivity, Amanda L. Rodrigue, Dana Mastrovito, Oscar Esteban, Joke Durnez, Marinka M. G. Koenis, Ronald Janssen, Aaron Alexander-Bloch, Emma M. Knowles, Samuel R. Mathias, John Blangero

School of Medicine Publications

Background: Progress in precision psychiatry is predicated on identifying reliable individual-level diagnostic biomarkers. For psychosis, measures of structural and functional connectivity could be promising biomarkers given consistent reports of dysconnectivity across psychotic disorders using magnetic resonance imaging.

Methods: We leveraged data from four independent cohorts of patients with psychosis and control subjects with observations from approximately 800 individuals. We used group-level analyses and two supervised machine learning algorithms (support vector machines and ridge regression) to test within-, between-, and across-sample classification performance of white matter and resting-state connectivity metrics.

Results: Although we replicated group-level differences in brain connectivity, individual-level classification …

The Impact Of Leadership And Institutional Priorities On Degree Completion Of Community College Students, Estelle L. Garza

Electronic Theses and Dissertations

This study explored student perceptions of leadership and the impact they believed it to have on their ability to complete a degree at a community college district. Community college degree completion is both a statewide and national problem as most students who start a degree program will drop out before reaching the requirements to finish their degree, which can hurt their career opportunities and the economy. The purpose of this study was to determine how students perceive factors like leadership and their satisfaction with institutional priority factors to impact degree completion. This study used action research and a mixed methods …

Part-Time Enrolled Community College Students: A Case Study Examining The Experiences Of The Invisible Majority, Janelle M. Green

Electronic Theses and Dissertations

This qualitative research used multiple case study methodology to explore the perceptions and experiences of part-time enrolled students at multicampus urban community colleges in the Southwest region of the United States. Of particular interest was how students defined success and their perception of what it took to achieve success, the utilization rate of student success resources, challenges encountered that caused a student to consider stopping out, the quality of relationships and connections part-time students had with faculty and staff, and the experience students had navigating institutional systems and processes. This study was conducted at a large, public, urban, multicampus community …

Youth Leadership Development Programs: Participants’ Pre- And Post-Perceptions Of Leadership Life Skills Development, Courtney A. Pruner

Electronic Theses and Dissertations

Research exists on the participation of youth in various types of youth leadership development programs. However, the problem is a lack of understanding of the perception of participants’ pre- and postparticipation on their development of leadership life skills. The purpose of this quantitative, causal-comparative study was to determine how youth leadership development program participants perceive themselves in the area of leadership life skills development pre- and postparticipation in a youth leadership development program. In this study, specific consideration was given to the difference in gender and ethnic minority affiliation reporting scores. The independent variables in this study were participation in …

Mechanisms And Applications Of Improved Protein Analysis By Desorption Electrospray Ionization Mass Spectrometry (Desi-Ms), Roshan Javanshad

Dissertations

Electrospray ionization mass spectrometry (ESI-MS) is a soft ionization technique that allows detection of macromolecules, such as intact proteins, by the formation of multiply charged ions from solutions. Desorption electrospray ionization mass spectrometry (DESI-MS) is an ambient ionization technique that directly samples analyte from a surface during ESI-MS analysis. Although DESI-MS is highly accomplished at the analyses of metabolites, lipids, and other small molecules, it is far more limited when it comes to protein analysis. While most of the field in ambient ionization MS has moved towards primarily applications, our approach has been to explore the use of DESI-MS and …

Parametric Characteristics Of The B6omsi-Re, Sarahelizabeth Janemarie Baguhn

Dissertations

Orientation and mobility specialists for young children who are blind or visually impaired have relied on informal assessments or commercially available tools designed for sighted children to track developmental progress. When Bradley-Johnson (1994) literally wrote the book on assessment in blindness, the sharing and refinement of common tools led to professionals working in teams to sift and winnow the checklists, and move the best available tools into wider circulation. This has led to the evolution of the practitioner made tools becoming the published tools, although they have not yet had statistical evidence to support their efficacy. This three-paper dissertation aims …

Advanced Risk Models To Predict Surgical Site Infections Using Machine Learning Approaches And Risk-Adjusted Control Charts, Rabia Emhamed Al Mamlook

Dissertations

Even though most infections are treatable with antibiotics, Surgical Site Infections (SSIs) remain a significant healthcare problem as they increase hospital stays, require additional treatments, reduce a patient’s quality of life, and increase morbidity and mortality. To reduce the risks and to encourage the highest quality healthcare, it is important to measure, predict, and monitor the risk of SSIs. Preoperative prediction of SSIs is essential to facilitate the implementation of preventative strategies for high-risk patients. The overarching goal of this dissertation is to investigate new opportunities of using machine-learning (ML) to improve the accuracy and use of pre-operative prediction models …

Conditional Wasserstein Generative Adversarial Networks Applied To Acoustic Metamaterial Design, Peter Lai, Feruza Amirkulova, Peter Gerstoft

Faculty Research, Scholarly, and Creative Activity

This work presents a method for the reduction of the total scattering cross section (TSCS) for a planar configuration of cylinders by means of generative modeling and deep learning. Currently, the minimization of TSCS requires repeated forward modelling at considerable computer resources, whereas deep learning can do this more efficiently. The conditional Wasserstein generative adversarial networks (cWGANs) model is proposed for minimization of TSCS in two dimensions by combining Wasserstein generative adversarial networks with convolutional neural networks to simulate TSCS of configuration of rigid scatterers. The proposed cWGAN model is enhanced by adding to it a coordinate convolution (CoordConv) layer. …

The Future Is Big - And Small: Remote Sensing Enables Cross- Scale Comparisons Of Microbiome Dynamics And Ecological Consequences, Deanna S. Beatty, Lillian R. Aoki, Olivia J. Graham, Bo Yang

Faculty Research, Scholarly, and Creative Activity

Coupling remote sensing with microbial omics-based approaches provides a promising new frontier for scientists to scale microbial interactions across space and time. These data-rich, interdisciplinary methods allow us to better understand interactions between microbial communities and their environments and, in turn, their impact on ecosystem structure and function. Here, we highlight current and novel examples of applying remote sensing, machine learning, spatial statistics, and omics data approaches to marine, aquatic, and terrestrial systems. We emphasize the importance of integrating biochemical and spatiotemporal environmental data to move toward a predictive framework of microbiome interactions and their ecosystemlevel effects. Finally, we emphasize …

The Human Right To Water And Sanitation: Using Natural Language Processing To Uncover Patterns In Academic Publishing, Christopher Michael Faulkner, Joshua Earl Lambert, Bruce M. Wilson, Matthew Steven Faulkner

Faculty Research, Scholarly, and Creative Activity

After years of advocacy and international negotiation, the General Assembly of the United Nations voted to officially recognize a stand-alone human right to water and sanitation on 28 July 2010. Since, academic scholarship has continued to grow in an effort to understand the implications of the codification of this human right. Yet, with this growth, it has become impractical if not impossible for scholars to keep up with the advancement of academic knowledge or to make sense of it in a systematic way. In short, to date, we know very little about the trends in the literature as they have …

Supervision Of A Self-Driving Vehicle Unmasks Latent Sleepiness Relative To Manually Controlled Driving, Erin E. Flynn-Evans, Lily R. Wong, Yukiyo Kuriyagawa, Nikhil Gowda, Patrick F. Cravalho, Sean Pradhan, Nathan H. Feick, Nicholas G. Bathurst, Zachary L. Glaros, Theerawit Wilaiprasitporn, Kanika Bansal, Javier O. Garcia, Cassie J. Hilditch

Faculty Research, Scholarly, and Creative Activity

Human error has been implicated as a causal factor in a large proportion of road accidents. Automated driving systems purport to mitigate this risk, but self-driving systems that allow a driver to entirely disengage from the driving task also require the driver to monitor the environment and take control when necessary. Given that sleep loss impairs monitoring performance and there is a high prevalence of sleep deficiency in modern society, we hypothesized that supervising a self-driving vehicle would unmask latent sleepiness compared to manually controlled driving among individuals following their typical sleep schedules. We found that participants felt sleepier, had …

Drivers Of Understory Plant Communities In Sierra Nevada Mixed Conifer Forests With Pyrodiversity, Kate Wilkin, Lauren Ponisio, Danny L. Fry, Brandon M. Collins, Tadashi Moody, Scott L. Stephens

Faculty Research, Scholarly, and Creative Activity

Background: Fire suppression in western North America increased and homogenized overstory cover in conifer forests, which likely affected understory plant communities. We sought to characterize understory plant communities and their drivers using plot-based observations from two contemporary reference sites in the Sierra Nevada, USA. These sites had long-established natural fire programs, which have resulted in restored natural fire regimes. In this study, we investigated how pyrodiversity—the diversity of fire size, severity, season, and frequency—and other environment factors influenced species composition and cover of forest understory plant communities. Results: Understory plant communities were influenced by a combination of environmental, plot-scale recent …

Community Norms Of The Muscle Dysmorphic Disorder Inventory (Mddi) Among Gender Minority Populations, Jason M. Nagata, Emilio J. Compte, F. Hunter Mcguire, Jason M. Lavender, Tiffany A. Brown, Stuart B. Murray, Annesa Flentje, Matthew R. Capriotti, Micah E. Lubensky, Juno Obedin-Maliver, Mitchell R. Lunn

Faculty Research, Scholarly, and Creative Activity

Purpose: Representing the pathological extreme pursuit of muscularity, muscle dysmorphia (MD) is characterized by a pervasive belief or fear around insufficient muscularity and an elevated drive for muscularity. Despite evidence of heightened body image-related concerns among gender minority populations, little is known about the degree of MD symptoms among gender minorities, particularly based on Muscle Dysmorphic Disorder Inventory (MDDI) scores. The objective of this study was to assess community norms of the MDDI in gender-expansive people, transgender men, and transgender women. Method: Data from participants in The PRIDE Study, an existing study of health outcomes in sexual and gender minority …

Head-Mounted Accelerometry Accurately Detects Prey Capture In California Sea Lions, Mason R. Cole, Jenifer A. Zeligs, Stefani Skrovan, Birgitte I. Mcdonald

Faculty Research, Scholarly, and Creative Activity

Detecting when and where animals feed is key to understanding their ecophysiology, but our ability to collect these data in marine mammals remains limited. Here, we test a tag-based accelerometry method to detect prey capture in California sea lions. From synchronized underwater video and acceleration data of two trained sea lions, we isolated a combined acceleration and Jerk pattern that reliably indicated prey capture in training datasets. We observed a stereotyped feeding motion in underwater video that included (1) mouth opening while approaching prey; (2) head deceleration to allow initial suction or prey engulfment, and (3) jaw closure. This motion …

Immunological And Hematological Outcomes Following Protracted Low Dose/Low Dose Rate Ionizing Radiation And Simulated Microgravity, Amber M. Paul, Eliah G. Overbey, Willian A. Da Silveira, Nathaniel Szewczyk, Nina C. Nishiyama, Michael J. Pecaut, Sulekha Anand, Jonathan M. Galazka, Xiao Wen Mao

Faculty Research, Scholarly, and Creative Activity

Using a ground-based model to simulate spaceflight [21-days of single-housed, hindlimb unloading (HLU) combined with continuous low-dose gamma irradiation (LDR, total dose of 0.04 Gy)], an in-depth survey of the immune and hematological systems of mice at 7-days post-exposure was performed. Collected blood was profiled with a hematology analyzer and spleens were analyzed by whole transcriptome shotgun sequencing (RNA-sequencing). The results revealed negligible differences in immune differentials. However, hematological system analyses of whole blood indicated large disparities in red blood cell differentials and morphology, suggestive of anemia. Murine Reactome networks indicated majority of spleen cells displayed differentially expressed genes (DEG) …