Digital Commons Network^™

Bacterial Production Of Human Discoidin Domain Receptor 2 (Ddr2) Kinase And Its Gatekeeper Mutants To Assess Activation By Phosphorylation, Dina Allam Abdel Azeem

Archived Theses and Dissertations

Discoidin domain receptor 2 (DDR2) belongs to a subfamily of receptor tyrosine kinases (RTKs) known as discoidin domain receptors (DDRs). DDRs are characterized by an extracellular discoidin homology domain and being activated by collagen resulting in a delayed but sustained activation. DDR2 overexpression was reported in some tumors, atherosclerosis as well as a number of inflammatory and fibrotic conditions. Recently 3 kinase inhibitor drugs (imatinib, nilotinib and dasatinib) were reported to inhibit DDR2 kinase activity suggesting it might have a role in their therapeutic effect. However minimal information is available on DDR2 downstream signaling. Identification of DDR2 substrates is essential …

Molecular Characterization Of Vibrio Cholerae Isolates From African Countries, Lamyaa S. Abdel Hamid

Archived Theses and Dissertations

Vibrio cholerae has caused seven global pandemics to date. The ongoing pandemic, caused by Vibrio cholerae serogroup O1 El Tor, has been the most extensive in geographical spread and duration. It began in 1961 in Indonesia spreading through Asia and the Middle East and finally reaching Sub Saharan West Africa at the early 1970s. In the first year of the pandemic alone, over 150,000 cases and more than 20,000 deaths were recorded. V. cholerae is currently responsible for several outbreaks in Africa, some with a reported high mortality rate. Although extensive characterization has been carried out on epidemic strains in …

Tjlp (2012) Volume 8 Issue 1

Tennessee Journal of Law and Policy

No abstract provided.

Umm Salama And Her Hadith, Yasmin Amin

Archived Theses and Dissertations

Narrations by notable Islamic personalities are a significant part of the Islamic religious edifice. However, these narrations are of variable quality and authenticity. To evaluate these narrations, standards and tools were developed and used. This study will look into whether or not it is possible to add a new tool that might aid in evaluating the narrations of an individual muḥaddith, using the example of Umm Salama. The study investigates Umm Salama from multiple perspectives to draw a rich picture of her. A detailed review of Umm Salama's life is presented, her genealogy reviewed, her character explored, her contributions to …

Moving Beyond Theory Into Practice: The Application Of The Human Rights Based Approach To Development By Egyptian Ngos, Reham Welson

Archived Theses and Dissertations

Human Rights based development is a central but vague and contested approach in development theory and practice. There is considerable rhetoric about its broad conception, techniques, mechanisms and its effect of constructing just relationships and empowering the weakest. In contrast, this thesis argues that existing interpretations and applications of the approach have overlooked the effect of relationships, power interactions, and dynamics of constructing a world view of the meaning, process and realization of the right. This relational perspective is utilized to investigate the work of four Egyptian NGOs working with the Participatory Development Program of the Canadian International Development Agency. …

Israeli Nuclear Deterrence: The Failure Of A Concept: "How Did The Change In Israel's Strategic Context Affect The Usefulness Of The Israeli Nuclear Deterrent?", Amr Nasr El-Din

Archived Theses and Dissertations

This study will aim at examining how the changes in Israelâ s security environment affected the strategic usefulness of its nuclear deterrent. The Israeli nuclear deterrent was developed during the 1950s and the 1960s when Israelâ s strategic setting was, mainly, dominated by state-centered security threats. Consequently, Israel, at the time, was mainly concerned with the possible symmetrical military confrontations with its Arab neighbors; something that would have created strategic value for the Israeli nuclear deterrent. Yet, a closer examination of the evolution of the Israeli security environment since 1982 will reveal that Non-State Actors (NSAs) and asymmetrical forms of …

Energy Efficient Configuration Or Perforated Solar Screens For Residential Desert Buildings, Rasha Arafa

Archived Theses and Dissertations

In hot arid desert environments, the solar radiation passing through windows increases the cooling loads and energy consumption of buildings. Shading of windows can reduce these loads. External perforated wooden solar screens were traditionally used for windowsâ shading. However, there is a lack in understanding their performance in a quantitative manner and unavailability of scientific means that could be used for developing new efficient designs that suit the harsh desert conditions. This thesis investigates the impact of changing screen configurations such as perforation percentage, depth, perforation openings aspect ratio and reflectivity on the energy loads, hence defining the most efficient …

The State Mosques Of The Arabian Gulf: Bridging Tradition And Modernity In The 20th, Yasmine M. A. Mohamed

Archived Theses and Dissertations

The architecture of the state mosques of the Arabian Gulf in the 20th century is an overlooked subject. Their various styles of Islamic architecture, lavish details, luxurious decoration and enormous scale are all intended to convey a message of elegance and power. While some research has been carried out on the Gulf States as part of modern urban development in general, little has been done on State Mosque architecture in particular, and few have been studied or even published in detail. Nevertheless, this region underwent more major changes in its contemporary mosque architecture from its traditional architecture than any of …

The Political Thought Of Qutb And Khomeini: A Comparative Study, Francisco Fernandez

Archived Theses and Dissertations

This thesis engages a comparative study of the political thought and practice of two of the foremost ideologues of political Islam in the twentieth century: Sayyid Qutb and Ayatollah Ruhollah Khomeini. The study explores each man’s revolutionary worldview and the strategies they advanced for the effectuation of change. In particular, the study highlights Qutb’s Milestones and Khomeini’s Lectures on Islamic Government. At the outset, an exploration of each man’s intellectual landscape sets the stage for a closer examination. Throughout, it is argued that their quest for a new order, while influenced by a particular reading of history, was informed above …

Isolation And Characterization Of A Novel Thermostable, Halotolerant L-Asparaginase Ii From The Metagenome Of The Red Sea; Atlantis Ii Brine Pool, Aya Medhat Saleh

Archived Theses and Dissertations

L-Asparaginases (E.C. 3.5.1.1) are group of enzymes which catalyze the hydrolysis of L-asparagine to L-aspartic acid and ammonia. Many microorganisms are known to produce two types of L-asparaginase. Considerable attention has been specifically drawn to type II L-asparaginases due to their potent tumor-inhibitory activity. Various limitations, such as high toxicity, poor stability and short half-life, are associated with the commercially available L-asparaginases used in cancer therapy. Additionally, L-asparaginases have a significant role in food industry owing to their ability to reduce the levels of acrylamide, which is a known neurotoxin and a potential carcinogen, in various food products. Knowing that …

Web Service Quality-Dased Profiling And Selection, Ahmed Magdi Hamza

Archived Theses and Dissertations

Guaranteeing quality of service has been recently labeled as one of multiple major research challenges in the service oriented architecture. In effect, Web service selection from a set of matched services offering the same functional requirements, and ultimately claiming certain quality of service guarantees about themselves is not enough. A need emerges for the existence of a trusted third party that monitors Web service quality indicators, yet in a way that does not interfere with the normal operation of the Web service itself. The third party will eventually provide consumers with guarantees about Web service quality. In this research we …

Crispr Diversity In Brine Pools Of The Red Sea: A Comparative Study Of Clustered Regularly Interspaced Short Palindromic Repeats From The Red Sea Metagenomes, Mohamed Mohamed Lotaief

Archived Theses and Dissertations

Exploration of CRISPR/Cas systems in the unique Red sea Brine pools can provide insights into host-viral interactions in highly extremophile environments. 454 Metagenomic datasets from different strata of Atlantis II, Discovery deep and Kebrit deep brine pools were mined for CRISPR arrays, and Cas proteins and compared to one another. Overall composition of CRISPR types was inferred by Cas protein HMM data, together with Cas1 phylogenetic placement using RaxML and direct repeat typing. Spacerâ viral interaction was explored using local alignments of mined spacer data to local metagenomic prophage sequences, showing and comparing specific sample CRISPR affected viral occurrences as …

Discrete Single-Hand Gestures For Wrist-Worn Device Control, Laura Fulton, Matthew Pateman, David L. Lee, Brett Lider, Bernice Go, Alex Faaborg

Defensive Publications Series

Interaction with wrist-worn devices is currently constrained to either voice control or opposing hand control through physical touch on the device screen, crown, or buttons. With one handed control involving full hand extension and hand clenching in a fist, these movements are not discrete. Traditional smartwatch placement on one hand is controlled using the other hand. This is a discrete, yet inconvenient mode of control, especially in situations where the other hand is involved in another function. Some technologies enable one-handed control with hand clenching into a fist / extending into an open palm. However, this isn't discrete or necessarily …

The Role Of Almunkkab City In Andalusian Political Life From The Umayyad Emirate Era To The Spanish Conquest (138-895 H.\755-1489 A.D), Amer Al-Qobbaj, Loay Abu Alsaud, Mohammad Al-Khateeb

An-Najah University Journal for Research - B (Humanities)

This study examines the role of Almunakkab in the political life of Al-Andalus between the years 755 and 1489. It was considered one of the major administrative and military centers of the Zirid Kingdom in addition to being the closest port to Granada and its only route to the sea. Almoravides were keen on keeping a hold of it and the significance of its role became clear as both Marinids and the Kingdom of Granada tried to maintain control over the vital Southern areas. Its port played a role against the Spanish forces. It had a presence in the internal …

Students Participation In Development Of Belonging In Saudi Universities, Hassan Al Qarni

An-Najah University Journal for Research - B (Humanities)

The study aimed at exploring the extent to which the Saudi University Students contribute to the development of the sense of national belonging as estimated by the students themselves. It also aimed at highlighting the effects of the variables of (gender, specialization, university) on the students' estimations. To achieve these goals, the researcher has developed a questionnaire that consisted- in its final draft- of (32) items distributed on three sub-scale and it was carried out on a sample consisting of (438) male and female students were chosen randomly. For the analysis of the students' responses, means, Standard Deviation, T-Test, ANOVA, …

The Waqf Of Qard Al-Hasan, Risks It May Encounter And Their Solutions )A Theoretical Study In Fiqh), Abdullah Çakır, Ahmad Abu- Sarhan

An-Najah University Journal for Research - B (Humanities)

The waqf is an institution of ongoing charity in the Sharia. That is to say, a person continues to get rewards even after death for undertaking such a charity. This study examines the qard al-hasan (benevolent loan free of interest) as the purpose of a waqf. The qard al-hasan is a legitimate, even recommended method of providing finance in Islam. It appears possible to implement this method in the waqf system. However, for this to be implemented, the legitimacy of this type of waqf and the risks it may encounter need to be addressed theoretically. In this context, the qard …

Developing Two Units Of Geography Textbook For Tenth Grade Student In Light Of Geographic Inquiry And Measuring Their Effect On Students' Acquisition Of Critical Thinking Skills In Jordan, Amal Sandoqa, Naseer Al-Khawaldeh

An-Najah University Journal for Research - B (Humanities)

This study aimed at identifying the effect of two developed units of the geography textbook for the 10th grade on students' acquisition of critical thinking skills in the light of the geographical inquiry approach. The semi- experimental approach was used to achieve the aim of current study. The sample of the study consisted of (88) female students from the Um Habbiya Secondary School for Girls, a public school in the Ministry of Education in Jordan. They were randomly assigned into two groups: an experimental group (45) students and controlled (43) students. To achieve the aim of the study, two units …

The Situation Of Spatial Development In Al-Mafraq Governorate, Faisal Almayouf

An-Najah University Journal for Research - B (Humanities)

This study aims to analyze development indicators in Mafraq governorate in order to assess and identity the economic and social reality of the population in this province. The study was based on the analytical descriptive approach as the appropriate method for the study. Analyzing the the available data showed that Al-Mafraq governate recorded the highest population growth rate in Jordan. Moreover, the study found that there is a clear lack of employment opportunities in the governorate due to the lack of investment projects capable of absorbing the labor force. The study recommended the necessity of achieving justice in the distribution …

Consolidation Of Mobile Sands With Ameliorants And Phytomelioration, Sharibay Toremuratov, Bakhtiyar Ismailov

Karakalpak Scientific Journal

The results of even a few experiments show the possibility of obtaining a tangible effect when jointly carrying out chemical reclamation and phytomelioration. Reliable habitation of plants is a guarantee of further long-term stopping of the movement of sand and improvement of the ecological situation.

Thus, the sand-fixing crust obtained by this method simultaneously performs several functions: it stops the movement of sand, reduces dust removal, creates favorable conditions for the growth and development of vegetation, contributes to the emergence of soil structures, the accumulation of humus, etc.

Molecular Attributes Transfer From Non-Parallel Data, Shuangjia Zheng, Ying Song, Pan Zhang, Le Song, Chengtao Li, Yuedong Yang

Machine Learning Faculty Publications

Optimizing chemical molecules for desired properties lies at the core of drug development. Despite initial successes made by deep generative models and reinforcement learning methods, these methods were mostly limited by the requirement of predefined attribute functions or parallel data with manually pre-compiled pairs of original and optimized molecules. In this paper, for the first time, we formulate molecular optimization as a style transfer problem and present a novel generative model that could automatically learn internal differences between two groups of non-parallel data through adversarial training strategies. Our model further enables both preservation of molecular contents and optimization of molecular …

Numerical Study Of Laminar Flow In A Suddenly Expanding Channel, Murodil Madaliev

Scientific-technical journal

The article presents the results of a numerical study of the flow structure in a flat channel in the zone of its sudden expansion in the form of a ledge. The calculations are based on the numerical solution of a system of non-stationary equations using Navier-Stokes. The results of the longitudinal velocity profiles in various sections of the channel after the ledge are obtained. For the difference approximation of the initial equations, the control volume method was used, and the relationship between velocities and pressure was found using the SIMPLE procedure. For the numerical solution of this problem, the McCormack …

Current And Future Directions Of Breast Mri, Margaret Houser, David Barreto, Anita Mehta, Rachel F. Brem

Radiology Faculty Publications

No abstract provided.

11-30-2021 Coody Family Honored By The Swosu College Of Pharmacy, Southwestern Oklahoma State University

THE BARK ARCHIVE 2021

No abstract provided.

11-30-2021 Aauw/Weatherford Branch Hosting Holiday Party This Thursday, Southwestern Oklahoma State University

THE BARK ARCHIVE 2021

No abstract provided.

Introduction To Malware Analysis, Harrison Dekker

Library Impact Statements

No abstract provided.

Audio Representations For Deep Learning In Sound Synthesis: A Review, Anastasia Natsiou, Sean O'Leary

Articles

The rise of deep learning algorithms has led many researchers to withdraw from using classic signal processing methods for sound generation. Deep learning models have achieved expressive voice synthesis, realistic sound textures, and musical notes from virtual instruments. However, the most suitable deep learning architecture is still under investigation. The choice of architecture is tightly coupled to the audio representations. A sound’s original waveform can be too dense and rich for deep learning models to deal with efficiently - and complexity increases training time and computational cost. Also, it does not represent sound in the manner in which it is …

Piano Majors Showcase

Printed Performance Programs (PDF Format)

No abstract provided.

Campus Assembly Minutes 11/30/2021, Campus Assembly

Campus Assembly

No abstract provided.

The Hubble Pancet Program: Transit And Eclipse Spectroscopy Of The Hot-Jupiter Wasp-74b, Guangwei Fu, Drake Deming, Erin May, Kevin Stevenson, David K. Sing, Joshua D. Lothringer, Hannah R. Wakeford, Nikolay Nikolov, Thomas Mikal-Evans, Vincent Bourrier, Leonardo A. Dos Santos, Munazza K. Alam, Gregory W. Henry, Antonio García Muñoz, Mercedes López-Morales

Information Systems and Engineering Management Research Publications

Planets are like children with each one being unique and special. A better understanding of their collective properties requires a deeper understanding of each planet. Here we add the transit and eclipse spectra of hot-Jupiter WASP-74b into the ever growing data set of exoplanet atmosphere spectral library. With six transits and three eclipses using the Hubble Space Telescope and Spitzer Space Telescope (Spitzer), we present the most complete and precise atmospheric spectra of WASP-74b. We found no evidence for TiO/VO nor super-Rayleigh scattering reported in previous studies. The transit shows a muted water feature with strong Rayleigh scattering extending into …

Mutants Of The White Abcg Transporter In Drosophila Melanogaster Have Deficient Olfactory Learning And Cholesterol Homeostasis, Jennifer L. Myers, Maria Porter, Nicholas Narwold, Krishna Bhat, Brigitte Dauwalder, Gregg Roman

Faculty and Student Publications

Drosophila’s white gene encodes an ATP binding cassette G-subfamily (ABCG) half transporter. White is closely related to mammalian ABCG family members that function in cholesterol efflux. Mutants of white have several behavioral phenotypes that are independent of visual defects. This study characterizes a novel defect of white mutants in the acquisition of olfactory memory using the aversive olfactory conditioning paradigm. The w¹¹¹⁸ mutants learned slower than wildtype controls, yet with additional training, they reached wildtype levels of performance. The w¹¹¹⁸ learning phenotype is also found in the w^apricot and w^coral alleles, is dominant, and is …