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Articles 79951 - 79980 of 5205125
Full-Text Articles in Entire DC Network
[Whm] Women's History Month - Government Resources, Raquel Estrada
[Whm] Women's History Month - Government Resources, Raquel Estrada
Library Display Posters
Poster highlighting U.S. government resources for Women’s History Month, offering statistics, exhibits, research guides, educational materials, and primary sources from agencies such as the U.S. Census Bureau, Library of Congress, National Archives, National Park Service, Smithsonian Institution, NASA, and U.S. Courts.
[Whm] Women's History Month 2026, Raquel Estrada
[Whm] Women's History Month 2026, Raquel Estrada
Library Display Posters
Poster showcasing films and books pertaining to women's history month. As well as a curated list of articles and dissertations/theses found in our institutional repository.
Digital Print Ordering System For Ugs, Han Nguyen
Digital Print Ordering System For Ugs, Han Nguyen
Graphic Communication
This project redesigns the UGS digital storefront to make ordering custom prints clearer and less confusing for students. Research showed that many delays happen because users submit incorrect files, such as wrong formats, low-resolution images, or missing fonts. To address this, I created an interactive prototype that guides users step-by-step through the ordering process and includes a built-in file checklist with simple export instructions. Instead of relying on a separate PDF guide, the new system supports users directly within the workflow, helping reduce errors and making the process smoother for both customers and UGS staffs.
Same, But Better: Modernizing A Professional Soccer Team’S Logo, Jessica A. Halladay
Same, But Better: Modernizing A Professional Soccer Team’S Logo, Jessica A. Halladay
Graphic Communication
Valencia CF is a historic soccer club with a highly recognizable crest, and this project focuses on modernizing that identity while preserving its core elements. Rather than creating a full rebrand, the project follows an identity evolution approach, refining the crest to improve clarity and adaptability across digital and physical applications. Guided by research in brand identity, social identity, and visual perception, the redesign focuses on four key elements: the bat, crest shape, typography, and soccer ball. Each component was simplified through iterative sketching and critique-based refinement to improve readability and consistency while maintaining recognizability. The final design demonstrates how …
Consolidation Enfortumab Vedotin And Pembrolizumab After Cisplatin Induction In Metastatic Urothelial Cancer: Outcomes Of Complete Response And Bladder Preservation, Kok Hoe Chan, Putao Cen, Tung Shu, Steven Canfield, Hui Zhao, Anneliese Gonzalez, Julie Rowe, Varaha Tammisetti, Hajar Ayoub, Angel Blanco, Mark Amsbaugh, Nizar Tannir
Consolidation Enfortumab Vedotin And Pembrolizumab After Cisplatin Induction In Metastatic Urothelial Cancer: Outcomes Of Complete Response And Bladder Preservation, Kok Hoe Chan, Putao Cen, Tung Shu, Steven Canfield, Hui Zhao, Anneliese Gonzalez, Julie Rowe, Varaha Tammisetti, Hajar Ayoub, Angel Blanco, Mark Amsbaugh, Nizar Tannir
Faculty, Staff and Student Publications
Bladder preservation remains a highly desirable therapeutic goal in urothelial carcinoma, particularly when durable survival can be achieved. Radical cystectomy is the standard treatment for muscle-invasive disease; however, it results in irreversible bladder loss and significant morbidity. Among patients with locally advanced or metastatic urothelial carcinoma, recurrence rates after standard therapy remain high. Consolidation therapy with enfortumab vedotin and pembrolizumab following cisplatin-based induction chemotherapy has demonstrated promising efficacy, with substantial complete response rates and improved bladder preservation. This single-center retrospective analysis evaluated the efficacy and safety of enfortumab vedotin plus pembrolizumab as consolidation therapy in 11 patients with metastatic urothelial …
Did A.T. Still, Do, Have An Md Degree?, David B. Fuller
Did A.T. Still, Do, Have An Md Degree?, David B. Fuller
PCOM Scholarly Works
A.T. Still, DO (1828–1917), founder of osteopathic medicine, was a licensed physician practicing in late 19th- and early 20th-century America. Although many assume he held an MD degree, the reality is more complex. Examining whether Dr. Still earned an MD degree provides important insight into the origins of osteopathic medicine and the profession that followed.
Student Success Story Session: Success Coaching & Student Insights, Maddie Martin, Ashley Gerhardt
Student Success Story Session: Success Coaching & Student Insights, Maddie Martin, Ashley Gerhardt
Student Success Analytics
Student Success Story Session focused on student insights from the Success Coaching program.
Uncopen: Celebrating 10 Years, University Of Northern Colorado Libraries
Uncopen: Celebrating 10 Years, University Of Northern Colorado Libraries
Policies & Documentation
An infographic about the accomplishments of the University of Northern Colorado's institutional repository in its first ten years.
Feasibility And Outcomes Of Perirectal Spacer Implantation In Previously Treated Prostate Cancer Patients Undergoing Salvage Proton Therapy Radiation., Irini Yacoub, Keyur Mehta, Daniel Gorovets, Shaakir Hasan, J Isabelle Choi, Arpit M Chhabra, Stanislav Lazarev, Madhur Garg, Charles B Simone
Feasibility And Outcomes Of Perirectal Spacer Implantation In Previously Treated Prostate Cancer Patients Undergoing Salvage Proton Therapy Radiation., Irini Yacoub, Keyur Mehta, Daniel Gorovets, Shaakir Hasan, J Isabelle Choi, Arpit M Chhabra, Stanislav Lazarev, Madhur Garg, Charles B Simone
Oncology Articles
PURPOSE: Treatment of recurrent prostate cancer following prior therapy is challenging due to the risk of toxicities to previously irradiated normal tissues, particularly the rectum. Proton therapy offers a conformal approach that may reduce this risk. Perirectal spacers have been shown to further minimize rectal dose in primary treatment, but the ability to be placed and their value in the retreatment setting have not been thoroughly evaluated to date. The purpose of this study was to evaluate feasibility of rectal spacer placement after prior pelvic radiation or other local treatments for prostate cancer.
METHODS AND MATERIALS: We conducted a retrospective …
Fair + Equitable March 2026, International Association Of Assessing Officers
Fair + Equitable March 2026, International Association Of Assessing Officers
Fair + Equitable
The March F+E issue presents an appraiser's experience to the massive fires in the Los Angeles area last year. Also in this issue:
- Companion article on the impact of technology updates in Los Angeles County.
- 2026 Annual Conference will open on Tuesday night in Calgary
- IAAO library monthly update
- Article on vision of an AI-powered assessment office
- Results of survey on GIS usage
- NACo, experts join effort for data access
- IAAO welcomes content editor
- IAAO notes passing of 1994 President
- Member news, new instructors, job announcements, designation results
Comparative Judicial Enforcement, Rosa Hayes, Angela Hefti
Comparative Judicial Enforcement, Rosa Hayes, Angela Hefti
Washington Law Review
Almost immediately upon his second inauguration, President Trump took several actions that subvert longstanding norms, contravene long-settled Supreme Court precedent, and disrespect the authority of the coordinate branches to check executive branch excess. The Administration’s actions pose both immediate and long-term challenges to the American constitutional order, with many scholars and citizens believing that the United States is in the midst of a constitutional crisis. At minimum, the Trump Administration’s actions have illuminated sticking points in both functionalist and formalist conceptions of the separation of powers. For this model of shared but distributed power to function, each branch must give …
A Right Without A Remedy: The Court’S Failure To Quantify The Agua Caliente’S Federal Reserved Water Rights, Lauren Block
A Right Without A Remedy: The Court’S Failure To Quantify The Agua Caliente’S Federal Reserved Water Rights, Lauren Block
Washington Law Review
The Agua Caliente Band of Cahuilla Indians has inhabited the Coachella Valley region since time immemorial. Through a series of 1870s executive orders, the United States government reserved land for the Tribe to establish a permanent home within the bounds of their ancestral homeland. Underlying this permanent home is the Coachella Valley aquifer, a groundwater source that has been in a continuous state of overdraft for decades. Against the backdrop of climate change, water scarcity, and other concerns, the Tribe sued Coachella Valley’s water management agencies in 2013, alleging the Tribe owned a portion of the water in the aquifer …
Pharmacy Matters March 2026, University Of Mississippi School Of Pharmacy
Pharmacy Matters March 2026, University Of Mississippi School Of Pharmacy
Pharmacy Matters Newsletters
Featured stories: Bringing NCCRE's Work to Center Stage in TEDx Presentation, SOP Alumnus Serves as Medical Liaison for Fiesta Bowl, Ole Miss Researcher Who Dives for Discovery Named Sigma Xi Fellow, Pharmacy Faculty Inducted into UMMC's Nelson Order, Planning Ahead for Generational Impact, Student Pharmacist Advocates at NACDS Rx Impact Day, Three SOP Alums Named 40 Under 40, Ole Miss Pharmacy Capitol Day 2026, American Association of Colleges of Pharmacy #Interim26
City Of La Voters' Preferences In Mayoral Race - March 2026 La Voter Poll, Thomas And Dorothy Leavey Center For The Study Of Los Angeles
City Of La Voters' Preferences In Mayoral Race - March 2026 La Voter Poll, Thomas And Dorothy Leavey Center For The Study Of Los Angeles
StudyLA Data Briefs
ABOUT THIS STUDY
The (March 2026) LA Voter Poll conducted by StudyLA involved a 20 minute online survey of 958 registered voters in LA County. The survey was conducted in English and Spanish between February 11th and March 16th, 2026 and respondents were asked a range of questions concerning Los Angeles and governance reform.
ABOUT THIS REPORT
Survey results are presented in two sections: (1) toplines, or total responses for each question and (2) crosstabs, or all questions crossed by major demographics. The following report presents data pertaining to all substantive questions. This survey was made possible through a generous …
Globalization And Structural Transformation: The Role Of Tradable Services, Sang Min Lee
Globalization And Structural Transformation: The Role Of Tradable Services, Sang Min Lee
Faculty Publications
This paper studies how globalization impacts structural transformation from goods to services. I construct a multi-country, multi-sector model in which the transformation occurs through changes in income, prices, comparative advantage, or input-output linkages. I parameterize it with data from 1995 to 2018 for 66 countries covering diverse stages of economic development. Decomposition exercises show that globalization outweighs productivity growth in shaping structural transformation and that globalization’s impact primarily operates through comparative advantage. Counterfactual exercises reveal globalization’s heterogeneous impact on countries’ structural transformation. I characterize the underlying factor behind this result: Globalization affected countries’ transformation to the extent that it altered …
The Library Papers (Vol. 1, Issue 5, March - April 2026), Wolf Law Library, William & Mary Law School
The Library Papers (Vol. 1, Issue 5, March - April 2026), Wolf Law Library, William & Mary Law School
Library Newsletter
No abstract provided.
Kras4a And Kras4b Show Distinct Lipid-Dependent Regulation Of Ras-Raf Membrane Dynamics, Konstantia Georgouli, Jeremy O.B. Tempkin, Liam G. Stanton, Tomas Oppelstrup, Rebika Shrestha, Timothy S. Carpenter, Fikret Aydin, Xiaohua Zhang, Harsh Bhatia, Yue Yang, Que N. Van, Pedro Andrade Bonilla, Gulcin Gulten, Debanjan Goswami, Francesco Di Natale, Joseph R. Chavez, Joseph Y. Moon, Gautham Dharuman, Nicolas W. Hengartner, For Full Author List, See Comments Below
Kras4a And Kras4b Show Distinct Lipid-Dependent Regulation Of Ras-Raf Membrane Dynamics, Konstantia Georgouli, Jeremy O.B. Tempkin, Liam G. Stanton, Tomas Oppelstrup, Rebika Shrestha, Timothy S. Carpenter, Fikret Aydin, Xiaohua Zhang, Harsh Bhatia, Yue Yang, Que N. Van, Pedro Andrade Bonilla, Gulcin Gulten, Debanjan Goswami, Francesco Di Natale, Joseph R. Chavez, Joseph Y. Moon, Gautham Dharuman, Nicolas W. Hengartner, For Full Author List, See Comments Below
Faculty Research, Scholarly, and Creative Activity
KRAS4a and KRAS4b are important regulators of signaling, and their interactions with the plasma membrane are dynamic and influenced by lipid composition. KRAS 4a and 4b have nearly identical globular domains but differ in their membrane-associated hyper variable region (HVR). The functional distinctions between these isoforms remain unclear, particularly with regards to their dependence on specific lipids and the membrane environment. Previous work showed that the membrane orientation of KRAS4b affects its ability to bind to RAF kinase RBDCRD and that the KRAS–RBDCRD complex adopts different poses on the membrane as well as influences the size and composition of the …
When Superstition Outperforms Truth: Belief Transmission, Sacrifice, And Cooperation Under Environmental Uncertainty, Aidin Hajikhameneh
When Superstition Outperforms Truth: Belief Transmission, Sacrifice, And Cooperation Under Environmental Uncertainty, Aidin Hajikhameneh
Faculty Research, Scholarly, and Creative Activity
We report results from an intergenerational experiment investigating how prosocial beliefs, whether accurate or false, emerge, spread, and support cooperation under environmental uncertainty (N=448, university students). In a repeated public goods game with randomly determined but ambiguously framed payoff shocks, participants often formed superstitious beliefs linking generosity to rewards. Compared to accurate beliefs, these superstitious beliefs, when transmitted to the next generation and internalized, led to greater cooperation and facilitated group formation via voluntary sacrifice. Individuals who held such beliefs were more likely to sacrifice and self-organize into high-functioning groups, achieving the highest levels of public good provision. These findings …
Thermodynamically Consistent Incorporation Of The Langmuir Adsorption Model Into Compressible Fluctuating Hydrodynamics, Hyun Tae Jung, Hyungjun Kim, Alejandro L. Garcia, Andrew J. Nonaka, John B. Bell, Ishan Srivastava, Changho Kim
Thermodynamically Consistent Incorporation Of The Langmuir Adsorption Model Into Compressible Fluctuating Hydrodynamics, Hyun Tae Jung, Hyungjun Kim, Alejandro L. Garcia, Andrew J. Nonaka, John B. Bell, Ishan Srivastava, Changho Kim
Faculty Research, Scholarly, and Creative Activity
For a gas–solid interfacial system where chemical species undergo reversible adsorption, we develop a mesoscopic stochastic modeling method that simulates both gas-phase hydrodynamics and surface coverage dynamics by coupling the Langmuir adsorption model with compressible fluctuating hydrodynamics. To this end, we derive a thermodynamically consistent mass–energy update scheme that accounts for how the mass and energy variables in the gas and surface subsystems should be updated according to the changes in the number of molecules of each species in each subsystem due to adsorption and desorption events. By performing a stochastic analysis for the ideal Langmuir model and the full …
Nominal Prices, Retail Investor Participation, And Return Momentum, Jun Du, Dashan Huang, Yu-Jane Liu, Yushui Shi, Avanidhar Subrahmanyam, Huacheng Zhang
Nominal Prices, Retail Investor Participation, And Return Momentum, Jun Du, Dashan Huang, Yu-Jane Liu, Yushui Shi, Avanidhar Subrahmanyam, Huacheng Zhang
Research Collection Lee Kong Chian School Of Business
We employ an identification strategy for retail participation to explore the link between return momentum and investing clientele. This scheme relies on strictly enforced round-lot rules in China, which financially constrain retail investors from participating in stocks with high nominal prices. We find that there is strong momentum in high-priced stocks, but no momentum on aggregate. This result supports the idea that noise trades of retail investors mask momentum, while other, more sophisticated investors contribute to momentum. We validate this notion by showing that retail investors with small (large) portfolios are less (more) prone to participating in stocks with high …
Global Value Chains And Economic Inequality, Vivek Soundararajan, Ari Van Assche, Hari Bapuji, Gokhan Ertug
Global Value Chains And Economic Inequality, Vivek Soundararajan, Ari Van Assche, Hari Bapuji, Gokhan Ertug
Research Collection Lee Kong Chian School Of Business
In their inaugural editorial, Van Assche and De Marchi (2024) argued that meaningful progress in international business policy requires a more fine-grained understanding of how private international business practices intersect with public policy objectives. This editorial builds on that insight by applying it to a critical yet still underexplored issue – one on which we hope to see more research in this journal: the role of multinational enterprises (MNEs) and global value chains (GVCs) in shaping economic inequality within developing economies. Decisions related to sourcing, contracting, and GVC governance are inherently distributional rather than neutral, with important implications for how …
From Comfort Zone To Growth Zone: Experiential Projects As Catalysts For Creativity In Pre-Service Teachers, Serap Sevimli-Celik, Elif Güvelioglu
From Comfort Zone To Growth Zone: Experiential Projects As Catalysts For Creativity In Pre-Service Teachers, Serap Sevimli-Celik, Elif Güvelioglu
Research outputs 2022 to 2026
This study aimed to analyze the creative experiences of early childhood pre-service teachers enrolled in a semester-long course designed to enhance their creative potential through experiential projects. Using a qualitative research design, this study explored the subjective experiences of 16 pre-service teachers, aged 21 to 23-years-old, who participated in a 14-week course focused on integrating creativity into early childhood education. Data were collected through weekly reflections, project reports, and multimedia documentation, capturing each pre-service teacher's creative journey. The findings revealed four key themes which characterized the pre-service teachers’ creative experiences: (1) learning a new skill, (2) expressing creativity and experiencing …
Orthogonal Time Frequency Space Modulation For Underwater Acoustic Communication Systems: A Review, Bevek Subba, Quoc Viet Phung, Stefan Lachowicz, Walid K. Hasan, Muhammad Haziq, Daryoush Habibi, Iftekhar Ahmad
Orthogonal Time Frequency Space Modulation For Underwater Acoustic Communication Systems: A Review, Bevek Subba, Quoc Viet Phung, Stefan Lachowicz, Walid K. Hasan, Muhammad Haziq, Daryoush Habibi, Iftekhar Ahmad
Research outputs 2022 to 2026
Underwater Acoustic Communication (UAC) has garnered significant attention due to its applications in marine science, defence, and exploration. With the vast majority of the Earth's surface covered by water, there is a growing demand for reliable and effective communication techniques in underwater environments. However, the underwater acoustic channel is the most challenging channel due to its harsh characteristics, which significantly hinder the reliability and performance of UAC systems. Orthogonal Time Frequency Space (OTFS) modulation has emerged as a promising solution for next-generation UAC systems to address high Doppler and high mobility scenarios. It has demonstrated tolerance to fast time-varying channel …
Shear Stability Enhancement In Fracture Plugging Zones: Unveiling Failure Mechanisms And Adhesive Benefits Through Photoelastic Analysis, Haoran Jing, Yili Kang, Chengyuan Xu, Lei Liu, Xiaopeng Yan, Zhenjiang You
Shear Stability Enhancement In Fracture Plugging Zones: Unveiling Failure Mechanisms And Adhesive Benefits Through Photoelastic Analysis, Haoran Jing, Yili Kang, Chengyuan Xu, Lei Liu, Xiaopeng Yan, Zhenjiang You
Research outputs 2022 to 2026
Addressing lost circulation during drilling operations typically involves the utilization of lost circulation materials (LCMs) to create a fracture plugging zone (FPZ), which effectively decouples the wellbore fluid column pressure (Pw) from the formation pressure (Pf). This FPZ, comprised of aggregated granular LCM particles, frequently succumbs to shear stress, with shear failure being the predominant mode of structural failure, leading to ongoing fluid losses. To illuminate the failure mechanisms of the FPZ under conditions of escalating drilling differential pressure (Pw - Pf), we utilized photoelastic experiments to capture and visualize the evolving mesoscopic mechanical structure of the FPZ. Photoelastic images …
Unilateral Online Ultrasound Stimulation Of Early Visual Cortex Suppresses Responses To Contralateral Visual Stimuli, Suraya Dunsford, Keith Murphy, Ema Darrieutort, Elsa Fouragnan, Giorgio Ganis
Unilateral Online Ultrasound Stimulation Of Early Visual Cortex Suppresses Responses To Contralateral Visual Stimuli, Suraya Dunsford, Keith Murphy, Ema Darrieutort, Elsa Fouragnan, Giorgio Ganis
School of Psychology
INTRODUCTION: Transcranial ultrasound stimulation (TUS) shows great promise for inducing neuroplastic changes that persist long after stimulation. Evidence of stimulation-locked (online) neural changes would enable the development of closed-loop application of TUS. However, such responses have been difficult to distinguish from coincident neural activity caused by auditory and somatosensory effects of TUS.
METHODS: To dissociate genuine online neuromodulatory effects from peripheral confounds, we leveraged the contralateral retinotopic organization of the early visual cortex in nineteen subjects. Using a hemifield visual stimulation paradigm combined with high-precision, functional MRI-guided TUS, we applied TUS to the left early visual cortex while participants viewed …
Magnetically Driven Engineering Of Magnetic Hydroxyapatite/Ca Ro Membranes: Enhancing Surface Physicochemical Properties For High-Performance Water Desalination, Fariba Oulad, Ali Akbar Zinatizadeh, Sirus Zinadini, Amir Razmjou, Sara Eavani
Magnetically Driven Engineering Of Magnetic Hydroxyapatite/Ca Ro Membranes: Enhancing Surface Physicochemical Properties For High-Performance Water Desalination, Fariba Oulad, Ali Akbar Zinatizadeh, Sirus Zinadini, Amir Razmjou, Sara Eavani
Research outputs 2022 to 2026
This research focuses on the development of innovative hydrophilic reverse osmosis (RO) hydroxyapatite/cellulose acetate (HAP/CA) and magnetic-hydroxyapatite (M-HAP)/CA membranes, utilizing a phase-inversion technique with varying nanoparticles (NPs) concentration. The positioning of magneto-responsive M-HAP NPs within the advanced M-HAP/CA membranes was adeptly controlled using magnetic guidance during immersion- precipitation process in a coagulation bath. This precise control enabled a densely organized arrangement of M-HAP NPs, shifting from the membrane's core to its upper separation layer. Consequently, the barrier properties, mechanical integrity, and surface characteristics of the advanced M-HAP/CA membranes saw significant enhancement due to the uniform distribution of hydrophilic porous NPs …
Quality Of Human-Genai Collaboration And Its Driving Factors: A Symbiotic Agency Perspective, Jiayu Shang, Dan Huang, Songshan (Sam) Huang
Quality Of Human-Genai Collaboration And Its Driving Factors: A Symbiotic Agency Perspective, Jiayu Shang, Dan Huang, Songshan (Sam) Huang
Research outputs 2022 to 2026
Generative AI (GenAI) is increasingly integrated into users’ daily work as a collaborative partner. Drawing on the symbiotic agency theory, this study investigates the quality of human-GenAI collaboration using a mixed-methods approach, including qualitative interviews and quantitative surveys. Study 1 identified three dimensions of human-GenAI collaboration quality that comprise outcome quality, comfort, and efficiency; and six driving factors which can be categorized under human agency (domain knowledge, desire for control, and domestication ability), and GenAI agency (communication ability, working memory, and long-term memory). Study 2 applied fuzzy-set qualitative comparative analysis (fsQCA) to explore configurations of the driving factors that lead …
An Explainable Transformer-Based Model For Phishing Email Detection: A Large Language Model Approach, Mohammad Amaz Uddin, Md Mahiuddin, Iqbal H. Sarker
An Explainable Transformer-Based Model For Phishing Email Detection: A Large Language Model Approach, Mohammad Amaz Uddin, Md Mahiuddin, Iqbal H. Sarker
Research outputs 2022 to 2026
Phishing email is a serious cyber threat that tries to deceive users by sending false emails with the intention of stealing confidential information or causing financial harm. Attackers, often posing as trustworthy entities, exploit technological advancements and sophistication to make the detection and prevention of phishing more challenging. Despite extensive academic research, phishing detection remains an ongoing and formidable challenge in the cybersecurity landscape. In this research paper, we present a fine-tuned transformer-based masked language model, RoBERTa (Robustly Optimized BERT Pretraining Approach), for phishing email detection. In the detection process, we employ a phishing email dataset and apply the preprocessing …
Automated Abdominal Aortic Calcification Scores And Atherosclerotic Cardiovascular Disease In The Uk Biobank Imaging Study, Marc Sim, James Webster, Cassandra Smith, Afsah Saleem, Syed Zulqarnain Gilani, Carlos J. Toro-Huamanchumo, David Suter, Gemma Figtree, Anne Karine Lagendijk, Emma L. Duncan, Carl Schultz, Pawel Szulc, Joseph Hung, Wai H. Lim, Parminder Raina, Nicola P. Bondonno, Richard Woodman, Jonathan M. Hodgson, Douglas P. Kiel, Richard L. Prince, William D. Leslie, John P. Kemp, Nicholas C. Harvey, John T. Schousboe, Joshua R. Lewis
Automated Abdominal Aortic Calcification Scores And Atherosclerotic Cardiovascular Disease In The Uk Biobank Imaging Study, Marc Sim, James Webster, Cassandra Smith, Afsah Saleem, Syed Zulqarnain Gilani, Carlos J. Toro-Huamanchumo, David Suter, Gemma Figtree, Anne Karine Lagendijk, Emma L. Duncan, Carl Schultz, Pawel Szulc, Joseph Hung, Wai H. Lim, Parminder Raina, Nicola P. Bondonno, Richard Woodman, Jonathan M. Hodgson, Douglas P. Kiel, Richard L. Prince, William D. Leslie, John P. Kemp, Nicholas C. Harvey, John T. Schousboe, Joshua R. Lewis
Research outputs 2022 to 2026
Background: Abdominal aortic calcification (AAC) is a subclinical measure of atherosclerotic cardiovascular disease (ASCVD). AAC can be captured on lateral spine images obtained from bone density machines during routine osteoporosis screening. Identifying individuals with AAC provides a new opportunity to prevent disease progression. Objectives: The aim of the study was to externally validate a machine learning-derived AAC 24-point algorithm (ML-AAC24) with incident ASCVD. Methods: Middle-aged individuals from the UK Biobank Imaging Study with lateral spine images, obtained via dual-energy x-ray absorptiometry, were included. ML-AAC24 scores were grouped as low (<2), moderate (2 to <6), and high (≥6). Linked health records were used to identify ASCVD-associated events, including hospitalizations and death. Results: Among 53,611 participants (52% female; mean age 65 years), 78.2% had low, 16.4% had moderate, and 5.4% had high ML-AAC24. After excluding people with prevalent ASCVD or missing data, 1,163 (2.3%) of 50,923 people had an incident ASCVD event over a median follow-up of 4.1 [3.0-5.5] years. In age- and sex-adjusted analysis, compared to those with low ML-AAC24, those with moderate (HR: 1.80 [95% CI: 1.57-2.08]) and high ML-AAC24 (HR: 2.87 [95% CI: 2.39-3.44]) had a higher HR for incident ASCVD. Results remained comparable after adjustment for established ASCVD risk factors. Consistent patterns were observed when considering incident coronary artery disease, myocardial infarction, and stroke. Conclusions: Assessing ML-AAC24 on lateral spine images offers a new and promising screening method to identify people with higher risk of incident ASVD events.