Digital Commons Network^™

Multi-Marker Immunofluorescent Staining And Pd-L1 Detection On Circulating Tumour Cells From Ovarian Cancer Patients, Du-Bois Asante, Michael Morici, Ganendra R. K. A. Mohan, Emmanuel Acheampong, Isaac Spencer, Weitao Lin, Paula Van Miert, Samantha Gibson, Aaron B. Beasley, Melanie Ziman, Leslie Calapre, Tarek M. Meniawy, Elin S. Gray

Research outputs 2014 to 2021

Detection of ovarian cancer (OC) circulating tumour cells (CTCs) is primarily based on targeting epithelial markers, thus failing to detect mesenchymal tumour cells. More importantly, the immune checkpoint inhibitor marker PD-L1 has not been demonstrated on CTCs from OC patients. An antibody staining protocol was developed and tested using SKOV-3 and OVCA432 OC cell lines. We targeted epithelial (cytokeratin (CK) and EpCAM), mesenchymal (vimentin), and OC-specific (PAX8) markers for detection of CTCs, and CD45/16 and CD31 were used for the exclusion of white blood and vascular endothelial cells, respectively. PD-L1 was used for CTC characterisation. CTCs were enriched using the …

Duty To Address Climate Change Litigation Risks For Australian Energy Companies—Policy And Governance Issues, Prafula Pearce

Research outputs 2014 to 2021

The transition from fossil fuels to renewable energy requires cooperation from all, including corporations, shareholders, and institutional investors. The purpose of this paper is to explore climate change litigation risks for Australian energy companies and investors from a policy and governance perspective. Companies are increasingly reporting their climate policies to satisfy their shareholders and investor demands. In addition, the government and judiciary are making laws and decisions to support the Paris Agreement. This paper explores whether company directors can and, in some cases, should be considering the impact of climate change litigation risks on their business, or else risk breaching …

Eccentric-Only Versus Concentric-Only Resistance Training Effects On Biochemical And Physiological Parameters In Patients With Type 2 Diabetes, Christine Kudiarasu, Wafina Rohadhia, Yoshihiro Katsura, Tomoko Koeda, Favil Singh, Kazunori Nosaka

Research outputs 2014 to 2021

Background:

The benefits of resistance training for patients with type 2 diabetes (T2D) are well documented; however, the effects of exercise with different muscle contraction types such as eccentric versus concentric contractions on physiological outcomes for this population are not clear. This study compared eccentric-only (ECC) and concentric-only resistance training (CON) to test the hypothesis that ECC would be superior to CON to improve insulin sensitivity, lipid profile, body composition, muscle strength and physical function of patients with T2D.

Methods:

Adults with T2D (50–79 years) were allocated to the ECC (n = 9) or CON group (n = 9). Resistance …

Nurses’ Perceptions Of Factors Influencing Treatment Engagement Among Patients With Cardiovascular Diseases: A Systematic Review, Amineh Rashidi, Lisa Whitehead, Prachi Kaistha

Research outputs 2014 to 2021

Background:

Nurses are key to the success of patient engagement, yet we know little about nurses’ perceptions on treatment engagement and how they can contribute to treatment engagement. Qualitative evidence to identify factors that influence treatment engagement among patients with CVD from nurse’s perspective is limited.

Methods:

This systematic review of qualitative research was based on the PRISMA reporting guidelines. The Joanna Briggs Institute (JBI) Critical Appraisal Checklist was used to assess quality by two reviewers independently. Data were collected from Medline, Web of Science, CINAHL, PsychINFO, Embase- Non-Medline, Scopus, and the Cochrane Library, were systematically searched from 2001 to …

A Case Report Of Covid-19 Monitoring In The Austrian Professional Football League, Antje Van Der Zee-Neuen, Dagmar Schaffler-Schaden, Jürgen Herfert, James O´Brien, Tim Johansson, Patrick Kutschar, Alexander Seymer, Stephan Ludwig, Thomas Stöggl, David Keeley, Herbert Resch, Jürgen Osterbrink, Maria Flamm

Research outputs 2014 to 2021

Since the beginning of the COVID -19 pandemic, many contact sport teams are facing major challenges to safely continue training and competition. We present the design and implementation of a structured monitoring concept for the Austrian national football league. 146 professional players from five clubs of the professional Austrian football league were monitored for a period of 12 weeks. Subjective health parameters, PCR- test results and data obtained from a geo-tracking app were collected. Simulations modelling the consequences of a COVID-19 case with increasing reproduction number were computed. No COVID -19 infection occurred during the observation period in the players. …

Influence Of Physical And Technical Aspects On Change Of Direction Performance Of Rugby Players: An Exploratory Study, Tomás T. Freitas, Pedro E. Alcaraz, Julio Calleja-González, Ademir F. S. Arruda, Aristide Guerriero, Valter P. Mercer, Lucas A. Pereira, Felipe P. Carpes, Michael R. Mcguigan, Irineu Loturco

Research outputs 2014 to 2021

We examined the relationships between change of direction (COD) speed and deficit, and a series of speed-and power-related measurements in national team rugby union players and analyzed the influence of movement patterns on COD ability. Eleven male athletes completed the following physical assessments on different days: day 1—anthropometric measurements, and lower-body kinematic parameters (assessed with eight inertial sensors) and completion time in COD tests (proagility, 45◦ cutting maneuver (CUT), and “L” (L-Drill)); day 2—bilateral and unilateral squat and countermovement jumps, 40 m linear sprint, and bar-power output in the jump squat and half-squat exercises. Pearson’s product–moment correlations were performed to …

Running Performance Of Male Versus Female Players In Australian Football Matches: A Systematic Review, Christopher Wing, Nicolas H. Hart, Callum Mccaskie, Petar Djanis, Fadi Ma’Ayah, Kazunori Nosaka

Research outputs 2014 to 2021

Background:

Australian Football is a fast paced, intermittent sport, played by both male and female populations. The aim of this systematic review was to compare male and female Australian Football players, competing at elite and sub-elite levels, for running performance during Australian Football matches based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).

Methods:

Medline, SPORTDiscus, and Web of Science searches, using search terms inclusive of Australian Football, movement demands and microsensor technology, returned 2535 potential manuscripts, of which 33 were included in the final analyses.

Results:

Results indicated that male athletes performed approximately twice the total …

An Enabling Environment For Asset Management Through Public Policy: The Benefits Of Standardization And Application To The Water Sector, Tiffany Batac, Kerry Brown, Rita Salgado Brito, Iain Cranston, Tetsuya Mizutani

Research outputs 2014 to 2021

Water services—including urban water supply, wastewater, and stormwater services—are essential to society and critical for protecting human health and the well-being of communities. Goal 6 of the United Nations (UN) Sustainable Development Goals (SDGs) recognizes this importance and aims to “ensure availability and sustainable management of water and sanitation for all.” Despite progress, the UN reports billions of people still lack water and sanitation services. Many governments around the world face the challenge of balancing between investment in new assets, programs, and services and providing the required funding for repair and replacement of existing water assets. This paper argues infrastructure …

Genotype-Specific Lesion Growth Rates In Stargardt Disease, Rachael C. Heath Jeffery, Jennifer A. Thompson, Johnny Lo, Tina M. Lamey, Terri L. Mclaren, Ian L. Mcallister, Ian J. Constable, John N. De Roach, Fred K. Chen

Research outputs 2014 to 2021

Reported growth rates (GR) of atrophic lesions in Stargardt disease (STGD1) vary widely. In the present study, we report the longitudinal natural history of patients with confirmed bial-lelic ABCA4 mutations from five genotype groups: c.6079C > T, c.[2588G > C;5603A > T], c.3113C > T, c.5882G > A and c.5603A > T. Fundus autofluorescence (AF) 30◦ × 30◦ images were manually seg-mented for boundaries of definitely decreased autofluorescence (DDAF). The primary outcome was the effective radius GR across five genotype groups. The age of DDAF formation in each eye was calculated using the x-intercept of the DDAF effective radius against age. Discordance between age at DDAF …

The Antecedents, Consequences, And Mediating Role Of Workload Among Chinese Courier Drivers, Haitao Wen, Hongduo Sun, Sebastian Kummer, Ben Farr-Wharton, David M. Herold

Research outputs 2014 to 2021

The growth of e-commerce in China can be regarded as a significant factor in the increase in occupational stress and the voluntary turnover of courier drivers. This paper aims to investigate selected occupational stress factors behind the turnover intentions of Chinese courier drivers. Using data from 229 couriers employed at the largest delivery companies in China, this study applies structural equation modelling to investigate not only the direct relationships between job-stress factors and turnover intentions but also the extent to which workload indirectly mediates turnover intentions among couriers. The results indicate that a combination of high workload with social stressors …

Nano-Grating Assisted Light Absorption Enhancement For Msm-Pds Performance Improvement: An Updated Review, Narottam Das, Mohammad Nur-E-Alam, Alif Islam, Ain Zulaikha Maslihan Ain

Research outputs 2014 to 2021

The primary focus of this review article mainly emphasizes the light absorption enhancement for various nanostructured gratings assisted metal-semiconductor-metal photodetectors (MSM-PDs) that are so far proposed and developed for the improvement of light capturing performance. The MSM-PDs are considered as one of the key elements in the optical and high-speed communication systems for applications such as faster optical fiber communication systems, sensor networks, high-speed chip-to-chip interconnects, and high-speed sampling. The light absorption enhancement makes the MSM-PDs an ideal candidate due to their excellent performances in detection, especially in satisfying the high-speed or high-performance device requirements. The nano-grating assisted MSM-PDs are …

Hydrogen Underground Storage Efficiency In A Heterogeneous Sandstone Reservoir, Doaa Saleh Mahdi, Emad A. Al-Khdheeawi, Yujie Yuan, Yihuai Zhang, Stefan Iglauer

Research outputs 2014 to 2021

Underground hydrogen storage has been recognized as a key technology for storing enormous amounts of hydrogen, thus aiding in the industrial-scale application of a hydrogen economy. However, underground hydrogen storage is only poorly understood, which leads to high project risk. This research thus examined the effect of caprock availability and hydrogen injection rate on hydrogen recovery factor and hydrogen leakage rate to address some fundamental questions related to underground hydrogen storage. A three dimensional heterogeneous reservoir model was developed, and the impact of caprock and hydrogen injected rate on hydrogen underground storage efficiency were analysed with the model. The results …

Diagnostic Yield Of Genetic Testing In 324 Infants With Hypotonia., Sonal Sharma, Elena Repnikova, Janelle R. Noel-Macdonnell Phd, Jean-Baptist Lepichon

Manuscripts, Articles, Book Chapters and Other Papers

This retrospective cohort study was designed to determine the yield of genetic tests in hypotonic infants and develop a diagnostic algorithm. Out of 496 patients identified by International Classification of Diseases (ICD) 9/10 coding, 324 patients met the inclusion criteria. Diagnostic yields were 32% for karyotype, 19% for microarray, 30% for targeted genetic tests, 38% for gene panels, and 31% for exome sequencing. In addition, we considered the diagnostic contribution of ancillary tests, including neuroimaging, metabolic tests, and so forth. The combination of microarray and exome sequencing gave the highest diagnostic yield. None of the other tests added significant value …

Commentary: Zoom Into The Coronary Anastomosis During Coronavirus Disease 2019 (Covid-19), Danial Ahmad, Vakhtang Tchantchaleishvili

Division of Cardiology Faculty Papers

No abstract provided.

Decline In Subarachnoid Haemorrhage Volumes Associated With The First Wave Of The Covid-19 Pandemic, Italo Linfante

All Publications

Background: During the COVID-19 pandemic, decreased volumes of stroke admissions and mechanical thrombectomy were reported. The study's objective was to examine whether subarachnoid haemorrhage (SAH) hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines.

Methods: We conducted a cross-sectional, retrospective, observational study across 6 continents, 37 countries and 140 comprehensive stroke centres. Patients with the diagnosis of SAH, aneurysmal SAH, ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases, 10th Revision, codes. The 3-month cumulative volume, monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period …

The Myth Of The Great Writ, Leah M. Litman

Articles

Habeas corpus is known as the “Great Writ” because it supposedly protects individual liberty against government overreach and guards against wrongful detentions. This idea shapes habeas doctrine, federal courts theories, and habeas-reform proposals.

It is also incomplete. While the writ has sometimes protected individual liberty, it has also served as a vehicle for the legitimation of excesses of governmental power. A more complete picture of the writ emerges when one considers traditionally neglected areas of public law that are often treated as distinct—the law of slavery and freedom, Native American affairs, and immigration. There, habeas has empowered abusive exercises of …

Towards Greater Investor Accountability: Indirect Actions, Direct Actions By States And Direct Actions By Individuals, Martin Jarrett, Sergio Puig, Steven R. Ratner

Articles

Investor accountability in international investment law (IIL) has been gaining increasing traction in recent years. Most visibly, some states have included investor obligations in their investment treaties, while others have made them part of their model treaties. While highly significant for the substance of IIL, these duties need adequate procedural tools to enforce them. Otherwise, investor obligations will be only decorative features of investment treaties without any legal meaning. The oft-discussed option of counterclaims is limited insofar as it may only be launched after an investor has made a claim against a state. As a result, it is important to …

Redemptive Suffering In A Contemporary Context, Allison Magera

Honors Program Theses and Research Projects

Redemptive suffering is a Christian understanding of suffering which holds that the pain and adversities of everyday life can be spiritually united to Christ’s suffering and death on the cross in petition for the needs and salvation of oneself or others. Salvifici Doloris proves to be a foundational document in comprehending the many facets of this concept theologically, but practically, personal prayer in petition is often how one can spiritually “share in the sufferings of Christ.” There is also potential for this theological concept to apply elsewhere in Christianity outside of Catholicism, and in practice this concept should be delivered …

Impact Of Local Covid-19 Policies On The Homeless Population: Case Study In Two Montana Counties, Franchesca D. Talbot

Capstone Experience: Master of Public Health

COVID-19 has had a significant impact on people experiencing homelessness in Montana. In each Montana County, local policies in addition to individual shelter policies determine the requirements for homeless shelters in relation to capacity, distancing, and other public health measures designed to prevent the spread of COVID-19. The policies often differ from county to county, which often lead to different outcomes across the state. This case study analyzed data from multiple sources on the number of COVID-19 cases and deaths among the homeless populations in Missoula and Lewis and Clark Counties in Montana and linked them to the effectiveness of …

Cadmium And Chromium Evaluation Of Offutt Air Force Base Aircraft Maintenance Bay, Nickolas Lamal

Capstone Experience: Master of Public Health

The 55th Aircraft Maintenance Squadron is based out of Offutt Air Force Base (AFB). The organization has requested testing of Air Ground Equipment (AGE) maintenance operations for heavy metals, specifically cadmium and chromium while evaluating one break area for the harmful compounds. It is hypothesized that heavy metals may be in excessive limits and could potentially harm staff and their families as take-home toxins. If left uninvestigated and evaluated, excessive exposure to heavy metals could cause injury or illness within the unit’s ranks, decreasing unit effectiveness and efficiency. Sampling methods include preliminary assessments of break area and adjacent glass bead …

Predictors Of Poor Glycemic Control In Diabetic Clients With Mental Health Illness, Community Alliance, Omaha, Nebraska, Rachelle Flick

Capstone Experience: Master of Public Health

People with severe mental illness tend to die 10-25 years earlier than the general population (WHO). Main contributors to these premature deaths include comorbidities such as hypertension, cardiovascular disease, and diabetes. Diabetes prevalence in mentally ill people is 2 times higher than the general population (WHO). The World Health Organization is taking action to improve the health of people with severe mental illness. These efforts include creating protocols of prevention, identification, assessment, and treatment for mentally ill people, as well as improving access to general health services through the integration of physical and mental health services. Community Alliance, located in …

A Literature Review Of Paid Sick Leave And Disparate Populations In The United States During The Covid Pandemic, Jessica Davies

Capstone Experience: Master of Public Health

The COVID pandemic is providing many public health and health policy learning opportunities to identify disparities among women, minorities, and underserved/distressed populations and inform subsequent policy-level strategies. It is recommended people stay home when they are sick; yet, not all people have access to paid sick leave. Individuals are left with the unfortunate decision to lose pay or go to work when they are ill. This is disconcerting in any given year with the annual flu illness and other communicable diseases; however, especially concerning during the COVID pandemic given the high virus transmissibility. Paid sick leave is not universally accessible …

Developing And Piloting An E-Learning Module On Respiratory Protection, Emily Girard

Capstone Experience: Master of Public Health

Respiratory diseases are one of the most common causes of occupational illnesses in the United States. Many occupations use personal protective equipment (PPE) in the form of respirators to protect against respiratory hazards when other control methods are not effective. However, some workers may not have had adequate training on their use. An e-learning module was developed to provide information about respirators and their use in agriculture. The interactions of matching, sorting, and review questions require the user to be an active participant with the goal of reinforcing the information. It was hypothesized the average summative assessment score would increase …

Evaluating Nebraska Ems Providers' Ability And Willingness To Respond To Bioterrorism Emergencies, Ryan Houser

Capstone Experience: Master of Public Health

Previous studies have found that public health systems within the United States are inadequately prepared for an act of biological terrorism. This study utilized an Internet-based survey to assess the level of preparedness and willingness to respond to a bioterrorism attack, and identify factors that predict preparedness and willingness among Nebraska Emergency Medical Service providers, who are key to resilience in the face of an attack. The survey was available for one month in 2021 during which 190 EMS providers responded to the survey. The subjects included Registered Nurses, doctors, EMTs, and paramedics. Only 10% of the respondents are both …

Gender Disparity In Obesity And Lifestyle Characteristics Among Adults In Mississippi, Jalysa M. Edwards

Capstone Experience: Master of Public Health

Obesity is a primary public health concern and is associated with several chronic health diseases that can have dire consequences. According to the World Health Organization (WHO), there were about 1.9 billion overweight adults aged 18 years and above and at least 650 million adults were obese worldwide in 2016. Adults living in Mississippi are of particular concern, due to the high obesity rate which has continued to increase over the past 25 years. Mississippi’s obesity rate is 37.3%, which is one of the highest rates of adult obesity in the United. While obesity increases the risk of disease outcomes, …

Occupational Injuries Associated With Workplace Violence In An Academic Medical Center, Rebecca J. Bonacci

Capstone Experience: Master of Public Health

Violence is a major source of workplace injury in the medical profession. Peer reviewed literature is lacking for workers that have injuries through violence from clients who have intellectual disabilities. Literature for hospital security is also lacking. In this study of workplace violence, we compared injuries among the occupational groups at an academic medical center from 2017-2020. We hypothesized that violence will be similar across the years. Occupational injury and illness data was obtained from an academic medical center. The number of violence cases was divided by the total number of injury cases and reported as a percentage. We found …

Factors Contributing To Trust Of Occupational Healthcare Services In Meatpacking Plants, Gabriella Ochoa

Capstone Experience: Master of Public Health

Meatpacking refers to the slaughtering of livestock and processing and packaging it into meat and other byproducts. Meatpacking is a large industry employing thousands of workers from various racial and socioeconomic backgrounds in Nebraska. These workers have experienced disparities in accessing occupational health services such as language barriers, fear of job loss, or deportation due to immigration status if these services were used. The purpose of this study was to investigate how trust in occupational health services varied among employees at a meatpacking plant in Nebraska by demographic characteristics, particularly by ethnicity, gender, and English language proficiency.

Derivation And Validation Of A General Predictive Model For Long Term Risks For Mortality And Invasive Cardiovascular Interventions In Congenital Heart Disease, David A. Danford

Capstone Experience: Master of Public Health

Introduction. Accurate assessment of prognosis is a key driver of clinical decision making in congenital heart disease (CHD), but is complicated because CHD represents such a diverse collection of conditions. The aim of this investigation is to derive, validate, and calibrate multivariable predictive models for time to surgical or catheter-mediated intervention (INT) in CHD and for time to death in CHD. Methods. 4108 unique subjects were prospectively and consecutively enrolled, and randomized to derivation and validation cohorts. Total follow up was 26,578 patient-years, with 102 deaths and 868 INTs. Accelerated failure time multivariable predictive models for the outcomes, based on …

Population-Level Prevalence Of Depression And Summary Statistics Of Women With At Least A Year Post-Final Menstruation With And Without Hysterectomy, Happiness Kingi

Capstone Experience: Master of Public Health

Background: Depression is associated with estrogen hormonal changes. There are few comparisons studies on the population-level prevalence of depression in women at least a year post final menstruation with and without hysterectomy.

Objectives: 1) To determine the population-level prevalence of depression in women with at least a year post final menstruation with and without hysterectomy and 2) to calculate the summary statistics of women with at least a year post final menstruation with and without hysterectomy

Methods: A population-based cross-sectional design was used. Respondents were female participants of the U.S. National Health and Nutrition Examination Survey (NHANES) …

Acute Inositol-Stabilized Arginine Silicate Improves Cognitive Outcomes In Healthy Adults, Joshua L. Gills, Anthony Campitelli, Megan Jones, Sally Paulson, Jennifer Rae Myers, Erica N. Madero, Jordan M. Glenn, James Komorowski, Michelle Gray

Health, Human Performance and Recreation Faculty Publications and Presentations

Inositol-stabilized arginine silicate (ASI) is an ergogenic aid that upregulates nitric oxide. Acute ASI supplementation improves working memory and processing speed in young adults but there is a lack of data examining other cognitive tasks. Therefore, the purpose of this study was to examine acute ASI effects on young healthy adults by assessing multiple cognitive domains. Nineteen young adults (20.9 ± 3.2 years) completed this randomized, double-blind, crossover study consuming ASI (1.5 g ASI + 12 g dextrose) and placebo (12 g dextrose). The participants completed the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and two digital cognitive …