Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 792511 - 792540 of 5160122

Full-Text Articles in Entire DC Network

Collaboration Between Librarians And Academics In The Department Of Information Studies For Curriculum Development In Kzn, Petros Pn Dlamini, Bethiweli Mlambo, T Masenya Dec 2021

Collaboration Between Librarians And Academics In The Department Of Information Studies For Curriculum Development In Kzn, Petros Pn Dlamini, Bethiweli Mlambo, T Masenya

Library Philosophy and Practice (e-journal)

The aim of this study is to assess the level of collaboration between librarians and Library and Information Science (LIS) academics for the development of the LIS curriculum, being aware that collaboration is an instructional strategy that positively affects student academic achievement. The term collaboration has become popular concept in areas of life where two or more individuals, organisations, institutions or nation embark upon a mutually agreed process. Collaboration provides the opportunity for experts and researchers to partner and fine-tune thoughts and develop strategies for multi-dimensional thinking towards achieving common and uniform practice. Collaboration between librarians and LIS academics has …


Users’ Satisfaction With Resources And Services Of Public Libraries: A Case Of Govt. Jinnah Public Library Sahiwal, Pakistan, Muhammad Tariq Mr, Ahmad Nawaz Mr, Rais Ahmad Samdani Dr Dec 2021

Users’ Satisfaction With Resources And Services Of Public Libraries: A Case Of Govt. Jinnah Public Library Sahiwal, Pakistan, Muhammad Tariq Mr, Ahmad Nawaz Mr, Rais Ahmad Samdani Dr

Library Philosophy and Practice (e-journal)

Public libraries play a pivotal role in the development of national culture, society, economy and other factors. Users have extreme importance when libraries are discussed. Good resources and services are essentially required for library users. The objective of this study was to evaluate the users’ satisfaction with the resources and services of a public library. Quantitative research approach based on survey method was used to conduct this study. A structured questionnaire was designed to collect the data from the registered members of Government Jinnah Public Library Sahiwal (GJPLS). Convenience sampling technique was applied to approach sample size of this study. …


A Study On Impact Of Library Resource Utilisation And Ict Literacy On Earning Of The Post-Graduate Students Of Assam, India, Arnob Paul, Masuma Ahmed Dec 2021

A Study On Impact Of Library Resource Utilisation And Ict Literacy On Earning Of The Post-Graduate Students Of Assam, India, Arnob Paul, Masuma Ahmed

Library Philosophy and Practice (e-journal)

Information and communication technology, or ICT, is a broad term for information technology that emphasises the importance of unified communications and telecommunications integration, as well as intelligent building management systems and audio-visual systems in modern information technology. ICT refers to all technical tools that are used to manage data and facilitate communication. It consists of computer and network hardware, as well as software and required applications. With the increasing demand for information and communication technology literacy among the young students, it is important to know the impact of ICT literacy on the level of part time income of the students. …


Inductor Free Methods For Breaking Dc Currents, Sudipta Sen Dec 2021

Inductor Free Methods For Breaking Dc Currents, Sudipta Sen

LSU Doctoral Dissertations

The current interruption in dc circuits is more difficult to achieve compared to the ac circuits because, unlike ac systems, dc circuits do not have the natural current zero-crossing. Presently there are three categories of basic dc breaker models namely mechanical, static, and hybrid dc breakers. As current power systems is moving more towards microgrids, DERs, Electric Vehicles (EVs), and with recent advancements in dc circuits, wide verities of dc power sources, and loads, dc breakers are very important in future system protection.

New alternate methods to break dc currents for low-voltage applications are proposed in this work. The proposed …


World Changers: Social Justice At The Heart Of Middle School Language Arts Curriculum, Mackenzie Mcclain Dec 2021

World Changers: Social Justice At The Heart Of Middle School Language Arts Curriculum, Mackenzie Mcclain

Honors Theses

English classrooms, at their best, are safe places for adolescents to critically engage with difficult issues presented in novels and the real world. One such issue is human trafficking, which is expected to soon become the world’s most profitable criminal industry (Knudsen, 2015). Incorporating values and instructional approaches from social justice pedagogy, I have designed a sixth-grade language arts unit plan about human trafficking based upon Francesco D’Adamo’s novel, Iqbal (2003). My purpose was to create resources, such as standards-based learning objectives, text sets, lesson plans, and student projects to use in my own classroom, as well as for teachers …


Lindenwood Digest, December 15, 2021, Lindenwood University Dec 2021

Lindenwood Digest, December 15, 2021, Lindenwood University

Lindenwood Digest

The Lindenwood Digest has been a digital employee newsletter since 2009.


Beach Hazards: Riu Funana, Cape Verde, C Stokes, G Masselink, T Scott, L Brodie Dec 2021

Beach Hazards: Riu Funana, Cape Verde, C Stokes, G Masselink, T Scott, L Brodie

School of Biological and Marine Sciences

No abstract provided.


On The Variability Of Flocculated Particle Characteristics In A Shallow Estuary, G Egan, G Chang, Aj Manning, Sg Monismith, Ob Fringer Dec 2021

On The Variability Of Flocculated Particle Characteristics In A Shallow Estuary, G Egan, G Chang, Aj Manning, Sg Monismith, Ob Fringer

School of Biological and Marine Sciences

No abstract provided.


Visual Field Progression In Glaucoma: Comparison Between Poplr And Answers, Iván Marín-Franch, Paul H. Artes, Andrew Turpin, Lyne Racette Dec 2021

Visual Field Progression In Glaucoma: Comparison Between Poplr And Answers, Iván Marín-Franch, Paul H. Artes, Andrew Turpin, Lyne Racette

School of Health Professions

No abstract provided.


The Five Ds Of Outpatient Antibiotic Stewardship For Urinary Tract Infections, Melanie C Goebel, Barbara W Trautner, Larissa Grigoryan Dec 2021

The Five Ds Of Outpatient Antibiotic Stewardship For Urinary Tract Infections, Melanie C Goebel, Barbara W Trautner, Larissa Grigoryan

Faculty, Staff and Students Publications

Urinary tract infections (UTI) are one of the most common indications for antibiotic prescriptions in the outpatient setting. Given rising rates of antibiotic resistance among uropathogens, antibiotic stewardship is critically needed to improve outpatient antibiotic use, including in outpatient clinics (primary care and specialty clinics) and emergency departments. Outpatient clinics are in general a neglected practice area in antibiotic stewardship programs, yet most antibiotic use in the United States is in the outpatient setting. This article provides a comprehensive review of antibiotic stewardship strategies for outpatient UTI in the adult population, with a focus on the "five Ds" of stewardship …


Minimally Invasive Postmortem Intestinal Tissue Sampling In Malnourished And Acutely Ill Children Is Feasible And Informative, Erika Feutz, Wieger Voskuijl, Peter J Finch, Ta-Chiang Liu, Robert H J Bandsma, Phillip I Tarr, Christopher Alan Moxon, Kelley Vanbuskirk, Sarah Lawrence, Grace Umutesi, Kirkby D Tickell, James A Berkley, Judd L Walson, Steve Kamiza, Donna M Denno Dec 2021

Minimally Invasive Postmortem Intestinal Tissue Sampling In Malnourished And Acutely Ill Children Is Feasible And Informative, Erika Feutz, Wieger Voskuijl, Peter J Finch, Ta-Chiang Liu, Robert H J Bandsma, Phillip I Tarr, Christopher Alan Moxon, Kelley Vanbuskirk, Sarah Lawrence, Grace Umutesi, Kirkby D Tickell, James A Berkley, Judd L Walson, Steve Kamiza, Donna M Denno

2020-Current year OA Pubs

BACKGROUND: Intestinal disorders such as environmental enteric dysfunction (EED) are prevalent in low- and middle-income countries (LMICs) and important contributors to childhood undernutrition and mortality. Autopsies are rarely performed in LMICs but minimally invasive tissue sampling is increasingly deployed as a more feasible and acceptable procedure, although protocols have been devoid of intestinal sampling to date. We sought to determine (1) the feasibility of postmortem intestinal sampling, (2) whether autolysis precludes enteric biopsies' utility, and (3) histopathologic features among children who died during hospitalization with acute illness or undernutrition.

METHODS: Transabdominal needle and endoscopic forceps upper and lower intestinal sampling …


Dread Nation And Deathless Divide, By Justina Ireland. Reviewed By Phillip Fitzsimmons., Phillip Fitzsimmons Dec 2021

Dread Nation And Deathless Divide, By Justina Ireland. Reviewed By Phillip Fitzsimmons., Phillip Fitzsimmons

Mythprint Book Reviews

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local discussion groups.


Half Sick Of Shadows, By Laura Sebastian. Reviewed By Mckenzie Peck, Mckenzie Peck Dec 2021

Half Sick Of Shadows, By Laura Sebastian. Reviewed By Mckenzie Peck, Mckenzie Peck

Mythprint Book Reviews

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local discussion groups.


Ward Based Goal Directed Fluid Therapy (Gdft) In Acute Pancreatitis (Gap) Trial: A Feasibility Randomised Controlled Trial [Isrctn 36077283], F Froghi, F Soggiu, F Ricciardi, C Vindrola-Padros, L Floros, D Martin, H Filipe, M Varcada, K Gurusamy, S Bhattacharya, A Fanshawe, B Dolcea, P Mathur, B Davidson Dec 2021

Ward Based Goal Directed Fluid Therapy (Gdft) In Acute Pancreatitis (Gap) Trial: A Feasibility Randomised Controlled Trial [Isrctn 36077283], F Froghi, F Soggiu, F Ricciardi, C Vindrola-Padros, L Floros, D Martin, H Filipe, M Varcada, K Gurusamy, S Bhattacharya, A Fanshawe, B Dolcea, P Mathur, B Davidson

Peninsula Medical School

Background: Goal-directed fluid therapy (GDFT) reduces complications in patients undergoing major general surgery. There are no reports of cardiac output evaluation being used to optimise the fluid administration for patients with acute pancreatitis (AP) in a general surgery ward. Method: 50 patients with AP were randomised to either ward-based GDFT (n=25) with intravenous (IV) fluids administered based on stroke volume optimisation protocol or standard care (SC) (n=25), but with blinded cardiac output evaluation, for 48-hours following hospital admission. Primary outcome was feasibility. Results: 50 of 116 eligible patients (43.1%) were recruited over 20 months demonstrating feasibility. 36 (72%) completed the …


P-P06 Ward Based Goal Directed Fluid Therapy (Gdft) In Acute Pancreatitis (Gap) Trial: A Feasibility Randomised Controlled Trial [Isrctn 36077283], F Froghi, F Soggiu, F Ricciardi, C Vindrola-Padros, L Floros, D Martin, H Filipe, M Varcada, K Gurusamy, S Bhattacharya, A Fanshawe, B Dolcea, P Mathur, B Davidson Dec 2021

P-P06 Ward Based Goal Directed Fluid Therapy (Gdft) In Acute Pancreatitis (Gap) Trial: A Feasibility Randomised Controlled Trial [Isrctn 36077283], F Froghi, F Soggiu, F Ricciardi, C Vindrola-Padros, L Floros, D Martin, H Filipe, M Varcada, K Gurusamy, S Bhattacharya, A Fanshawe, B Dolcea, P Mathur, B Davidson

Peninsula Medical School

No abstract provided.


Structural Stability Of Short Latency Alfalfa-Based Pastures In The Humid Pampa, Argentina, R. O. Refi, B. Martín Dec 2021

Structural Stability Of Short Latency Alfalfa-Based Pastures In The Humid Pampa, Argentina, R. O. Refi, B. Martín

IGC Proceedings (1977-2023)

The aim of this study was to search the effects of grazing intensity and nitrogen fertilization on the structural stability of a mixed pasture composed by alfalfa (latency group 9), brome grass, tall fescue and white clover, sown in April 1997. Rotational grazing was carried out with dairy cattle with high intensity (HI: up to 3-4 cm) or moderate intensity (LI: up to 8-10 cm), whenever the alfalfa showed basal regrowth. According to a split-plot design, grazing intensities were subdivided to assign three levels of nitrogen fertilization: N0, without fertilization; N1 with 50 kg N/ha per year; and N2 with …


Late Winter Dietary Overlap Among Greater Rheas And Domestic Herbivores On The Argentinean Flooding Pampa, G. Vacarezza, M. S. Cid, F. Milano Dec 2021

Late Winter Dietary Overlap Among Greater Rheas And Domestic Herbivores On The Argentinean Flooding Pampa, G. Vacarezza, M. S. Cid, F. Milano

IGC Proceedings (1977-2023)

This study evaluates the dietary overlap among greater rheas (Rhea americana L.) sheep and cattle in the Flooding Pampa, Buenos Aires, Argentina during late winter, when is observed the lowest forage availability. The work was carried out with the following forage classes (FC): warm and cool season grasses and forbs (legumes and no-legumes). Diet botanical composition was estimated by microanalysis of faeces. Principal Component Analysis and Kulcyznsky´s index of similarity were used for data analysis. Rhea populations selected diets with higher forb percentages. On the contrary, vegetation structure and their own morpho-physiology conditioned cattle to diets almost exclusively gramineous. …


Beef Calf Production Using Year-Round Grazing On Tropical Grass Pasture In Summer Combined With Cool Temperate Grass Pasture In Winter, Y. Nakanishi, K. Shindou, S. Watanabe, K. Yamamoto, K. Hagino Dec 2021

Beef Calf Production Using Year-Round Grazing On Tropical Grass Pasture In Summer Combined With Cool Temperate Grass Pasture In Winter, Y. Nakanishi, K. Shindou, S. Watanabe, K. Yamamoto, K. Hagino

IGC Proceedings (1977-2023)

Bahiagrass (Paspalum notatum Fluegge) showed a poor quality with low crude protein in summer but blood biochemical levels of grazing beef cows were similar to drylot feeding cows except of concentration of urea nitrogen. Italian ryegrass (Lolium multiflorum Lam) showed very good quality with high crude protein (about 20 percentage) in winter. And so, suckler cows gained live weight in winter and suckling calves were showed very high growth rate (daily gain was about 1.0 kg). Total live weight gains of grazing cows were higher than those of drylot feeding cows. Postpartum reproductive performances of grazing cows were …


Winter Grazing And Feeding Systems In Western Canada, Duane H. Mccartney, V. Baron, J. Basarab, E. Okine, G. Lastiwka, A. Depalme, D. Young Dec 2021

Winter Grazing And Feeding Systems In Western Canada, Duane H. Mccartney, V. Baron, J. Basarab, E. Okine, G. Lastiwka, A. Depalme, D. Young

IGC Proceedings (1977-2023)

Beef cow calf producers in Western Canada are looking for methods of extending the grazing season into the winter in order to lower winter feed costs. Dry beef cows were early or late weaned and grazed during the early months of winter on late seeded barley swaths (Hardlum vulgare L.) and compared to cows fed barley silage and free choice barley straw in a feeding yard. The swath grazed barley was late seeded in June and swathed in the silage stage in mid September. Cows successfully swath grazed for three winters from mid November until mid to late February …


Forage Management For Extending The Grazing Season, David W. Koch, C. M. Lux, J. W. Flake Dec 2021

Forage Management For Extending The Grazing Season, David W. Koch, C. M. Lux, J. W. Flake

IGC Proceedings (1977-2023)

Studies were conducted to determine ways to extend grazing season with forages adequate to meet the needs of grazing animals and to reduce the cost of livestock production. Perennial grasses were swathed, windrowed and left in the field until they were winter-grazed with bred heifers. Corn (Zea mays L.) was stockpiled for winter grazing with lambs and ewes. Windrowed grasses increased in acid detergent fiber (ADF) and neutral detergent fiber (NDF) compared with stored hay, but crude protein content, heifer weight gain and body condition change was similar for both forages. An economic value of $218 ha-1 from …


Acknowledgment Of Reviewers Dec 2021

Acknowledgment Of Reviewers

Journal of Food and Drug Analysis

No abstract provided.


Molecular Cartography Of Residue Pesticides On Grape Surface In 3d By Ambient Ionization Tandem Mass Spectrometry, Hung Su, Tiao-Lai Huang, Cheng-Ting Chi, Yi-Tzu Cho, Chi-Wei Lee, Jingyueh Jeng, Jentaie Shiea Dec 2021

Molecular Cartography Of Residue Pesticides On Grape Surface In 3d By Ambient Ionization Tandem Mass Spectrometry, Hung Su, Tiao-Lai Huang, Cheng-Ting Chi, Yi-Tzu Cho, Chi-Wei Lee, Jingyueh Jeng, Jentaie Shiea

Journal of Food and Drug Analysis

Thermal desorption-electrospray ionization tandem mass spectrometry (TD-ESI/MS/MS) was used to characterize the residual pesticides that were collected from the surface of a grape with metallic sampling probes. Fungicides, insecticides, and miticides were detected, where results were validated by simple solvent extraction followed by gas chromatography tandem mass spectrometry and liquid chromatography tandem mass spectrometry analyses. To explore the distribution of pesticide residues on grape surfaces, 149 locations of a grape surface were collected and followed by TD-ESI/MS/MS analysis. The molecular cartography was then generated from analysis of residual pesticides on the grape surface in 3D.


Variations In Bovine Milk Oligosaccharides After Calving Using P-Aminobenzoic Ethyl Ester Closed-Ring Labeling And Negative Ion Electrospray Lc/Ms/Ms, Han-Ju Chien, Yi-Chun Ma, Yi-Feng Zheng, Cheng-Yu Kuo, Wei-Chen Wang, Guor-Rong Her, Chien-Chen Lai Dec 2021

Variations In Bovine Milk Oligosaccharides After Calving Using P-Aminobenzoic Ethyl Ester Closed-Ring Labeling And Negative Ion Electrospray Lc/Ms/Ms, Han-Ju Chien, Yi-Chun Ma, Yi-Feng Zheng, Cheng-Yu Kuo, Wei-Chen Wang, Guor-Rong Her, Chien-Chen Lai

Journal of Food and Drug Analysis

A strategy was proposed to analyze bovine milk oligosaccharides using p-aminobenzoic ethyl ester (ABEE) closed-ring labeling and C18 capillary liquid chromatography negative ion electrospray tandem mass spectrometry. Linkage specific fragment ions were used to identify oligosaccharide isomers. By constructing the mass chromatograms using linkage specific fragment ions, isomers were differentiated based on m/z values as well as temporal separation provided by liquid chromatography. In addition to disialyllactose and the single isomer lacto-N-neohexaose, four pairs of linkage isomers including 3’/6’-sialyllactose (3’/6’-SL), 3’/6’-sialyllactosamine (3’/6’-SLN), 3’/6’-sialylgalactosyl-lactose (3’/6’-SGL), and lacto-N-tetraose/lacto-N-neotetraose (LNT/LNnT) in bovine milk were investigated. Variations of bovine milk oligosaccharides in a …


Analysis Of Heterocyclic Aromatic Amines Using Selective Extraction By Magnetic Molecularly Imprinted Polymers Coupled With Liquid Chromatography – Mass Spectrometry, Shih-Ci Jhu, Jing-Ying Wang, Hsueh-Ting Wang, Sung-Fang Chen Dec 2021

Analysis Of Heterocyclic Aromatic Amines Using Selective Extraction By Magnetic Molecularly Imprinted Polymers Coupled With Liquid Chromatography – Mass Spectrometry, Shih-Ci Jhu, Jing-Ying Wang, Hsueh-Ting Wang, Sung-Fang Chen

Journal of Food and Drug Analysis

Heterocyclic aromatic amines (HCAs) are highly carcinogenic and mutagenic chemicals. This study reports on the development of magnetic molecularly imprinted polymers (MMIPs) for the purification and quantification of HCAs. A novel magnetic molecularly imprinted polymer was successfully prepared using a surface molecular imprinting method using functionalized Fe particles as the magnetic cores. 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) was used as a molecular template; methacrylic acid (MAA), ethylene glycol dimethyl acrylate (EGDMA), 2, 2′-Azobis (2-methylpropionitrile) were used as the functional monomer, crosslinker, and initiator, respectively. The use of the template/functional monomer/crosslinking agent at a ratio of 1:4:20 resulted in a product with better adsorption …


The Impact Of The Rare Disease And Orphan Drug Act In Taiwan, Ning-Chun Hsiang, Weng-Foung Huang, Churn-Shiouh Gau, Teng-Wen Tsai, Lin-Chau Chang Dec 2021

The Impact Of The Rare Disease And Orphan Drug Act In Taiwan, Ning-Chun Hsiang, Weng-Foung Huang, Churn-Shiouh Gau, Teng-Wen Tsai, Lin-Chau Chang

Journal of Food and Drug Analysis

The Rare Disease and Orphan Drug Act (the Act) was enacted in 2000 in Taiwan for the facilitation of the research, development, and accessibility of orphan drugs and special nutritional foods; for the prevention and early diagnosis of rare diseases; and for providing intensive care for patients with rare diseases. The aim was to investigate the impact of the Act on the availability and use of orphan drugs in Taiwan in the hope of identifying the remaining challenges and possible solutions to assist future policy making, which may be applicable in other countries as well. The information and statistics for …


Determination Of Quetiapine And Its Metabolites In Plasma By Field-Enhanced Sample Stacking, Tai-Ling Liu, Li-Shan Fang, Jing-Ru Liou, Jia-Shan Dai, Yen-Ling Chen Dec 2021

Determination Of Quetiapine And Its Metabolites In Plasma By Field-Enhanced Sample Stacking, Tai-Ling Liu, Li-Shan Fang, Jing-Ru Liou, Jia-Shan Dai, Yen-Ling Chen

Journal of Food and Drug Analysis

Quetiapine is an atypical antipsychotic drug that can be used to treat mental disorders, including schizophrenia, bipolar disorder and Alzheimer's disease. Quetiapine is mainly converted into the active metabolites of norquetiapine and 7-hydroxyquetiapine by the liver enzymes CYP3A4 and CYP2D6. In this study, liquid-liquid extraction (LLE) was used as a sample pretreatment method to eliminate interferences in plasma. tert-Butyl methyl ether was chosen as the extraction solvent. Field-enhanced sample injection (FESS), an online preconcentration technique, was used to analyze quetiapine and its metabolites norquetiapine and 7-hydroxyquetiapine in plasma. The optimal separation condition was 120 mM phosphate (pH 4.0) containing …


Quantitative Analysis Of Fragrance Allergens In Various Matrixes Of Cosmetics By Liquid-Liquid Extraction And Gc-Ms, Chia-Hui Lu, Ming-Chih Fang, Yu-Zi Chen, Shou-Chieh Huang, Der-Yuan Wang Dec 2021

Quantitative Analysis Of Fragrance Allergens In Various Matrixes Of Cosmetics By Liquid-Liquid Extraction And Gc-Ms, Chia-Hui Lu, Ming-Chih Fang, Yu-Zi Chen, Shou-Chieh Huang, Der-Yuan Wang

Journal of Food and Drug Analysis

Fragrances are the most common chemicals in cosmetics to which people expose every day. However, the unwanted allergic reactions such as contact dermatitis caused by direct contact with fragrances may happen. In Directive 2003/15/EC of the EU, cosmetic product containing one or more of 26 fragrance allergens must be declared on the package label. In addition, commission regulation (EU) 2017/1410 amending Annexes II and III of cosmetic regulation 1223/2009 restricted fragrance chemical of methyl eugenol, and prohibited Lyral, atranol, chloroatranol to be used in cosmetic. In this study, an efficient and sensitive GC-MS method for 3 banned fragrances, 26 fragrance …


Diagnostic Ions Guided 2d-Locating Strategy For Characterization Of Chemical Analogues In Complex Herbal Medicines Using Liquid Chromatography-Ion Mobility-Mass Spectrometry, Meng-Ning Li, Zi-Xuan Zhang, Hui-Ying Wang, Wen Gao, Ping Li, Hua Yang Dec 2021

Diagnostic Ions Guided 2d-Locating Strategy For Characterization Of Chemical Analogues In Complex Herbal Medicines Using Liquid Chromatography-Ion Mobility-Mass Spectrometry, Meng-Ning Li, Zi-Xuan Zhang, Hui-Ying Wang, Wen Gao, Ping Li, Hua Yang

Journal of Food and Drug Analysis

Rapid characterization of chemical analogues in potentially toxic complex matrix was essential for prevention of accidental poisoning. On the basis of the fragment ions possessed not only the same retention times (RT) but the same drift times (DT) on liquid chromatography-ion mobility-mass spectrometry (LC-IM-MS), an alternating frames (AF)-data independent acquisition (DIA) was utilized for simultaneous detection and rapid match of precursor/product ions with a fast switch of low/high collision energy (CE). A diagnostic ions guided 2D-locating strategy was developed for identification of chemical analogues in potentially toxic herbal medicines using LC-IM-MS. Firstly, the 2D-locations (RT, DT) of diagnostic ions were …


Pharmacokinetics Of Panduratin A Following Oral Administration Of A Boesenbergia Pandurata Extract To Rats, Jihyun Won, Keumhan Noh, Jae-Kwan Hwang, Beom Soo Shin, Wonku Kang Dec 2021

Pharmacokinetics Of Panduratin A Following Oral Administration Of A Boesenbergia Pandurata Extract To Rats, Jihyun Won, Keumhan Noh, Jae-Kwan Hwang, Beom Soo Shin, Wonku Kang

Journal of Food and Drug Analysis

Boesenbergia pandurata and its major active ingredient, panduratin A (PAN), exhibit antibacterial, anti-oxidant, anti-inflammatory, and anti-obesity effects. We explored the time course of the plasma and tissue (in the major organs, gums and skin) concentrations of PAN after oral administration of a B. pandurata extract to rats. Model-dependent analysis was used to quantify the skin distribution of PAN after systemic exposure. The PAN level peaked at 1.12 ± 0.22 μg/mL after 3 h, and then biexponentially decayed with a terminal half-life of 9 h. The mean clearance (Cl/F) was 2.33 ± 0.68 L/h/kg. The PAN levels in organs were in …


Identification Of Oxytocin Receptor Activating Chemical Components From Traditional Japanese Medicines, Yuko Maejima, Shoichiro Horita, Shoko Yokota, Tomoyuki Ono, Peter Proks, Hiromi Yoshida-Komiya, Yoichi Ueta, Katsuhiko Nishimori, Shingen Misaka, Kenju Shimomura Dec 2021

Identification Of Oxytocin Receptor Activating Chemical Components From Traditional Japanese Medicines, Yuko Maejima, Shoichiro Horita, Shoko Yokota, Tomoyuki Ono, Peter Proks, Hiromi Yoshida-Komiya, Yoichi Ueta, Katsuhiko Nishimori, Shingen Misaka, Kenju Shimomura

Journal of Food and Drug Analysis

Oxytocin (Oxt) is known to regulate social communication, stress and body weight. The activation of Oxt receptors (OTR) has clinical potential to abate stress disorders and metabolic syndrome. Kamikihito (KKT) is a traditional Japanese medicine used to treat psychological stress-related disorders. We investigated the effects of KKT, its ingredients and chemical components on Oxt neurons and OTR. C-Fos expression was examined after oral and peripheral administration of KKT in rats. Electrophysiological change of Oxt neurons and Oxt release upon application of KKT were measured in rat brain slice. The direct effect of KKT, its ingredients and its chemical components were …