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Rare Coding Variants In Rcn3 Are Associated With Blood Pressure, Karen Y. He, D.C. Rao, Et Al. Jan 2022

Rare Coding Variants In Rcn3 Are Associated With Blood Pressure, Karen Y. He, D.C. Rao, Et Al.

2020-Current year OA Pubs

No abstract provided.

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Isotopically Nonstationary 13c Metabolic Flux Analysis In Resting And Activated Human Platelets, Cara L Sake, Alexander J Metcalf, Michelle Meagher, Jorge Di Paola, Keith B Neeves, Nanette R Boyle Jan 2022

Isotopically Nonstationary 13c Metabolic Flux Analysis In Resting And Activated Human Platelets, Cara L Sake, Alexander J Metcalf, Michelle Meagher, Jorge Di Paola, Keith B Neeves, Nanette R Boyle

2020-Current year OA Pubs

Platelet metabolism is linked to platelet hyper- and hypoactivity in numerous human diseases. Developing a detailed understanding of the link between metabolic shifts and platelet activation state is integral to improving human health. Here, we show the first application of isotopically nonstationary

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Cal Poly Construction Management Summer Bootcamp 2022, Mason A. Heinse Jan 2022

Cal Poly Construction Management Summer Bootcamp 2022, Mason A. Heinse

Construction Management

The purpose of this paper is to outline the intent and key objectives of the Cal Poly Construction Management Summer Bootcamp. This project was developed through collaboration with Cal Poly Construction Management faculty and other contributors to create a multi-scope project with the objective of creating a summer bootcamp. The camp was proposed to assist the San Luis Obispo County Office of Education and the Central Coast Homebuilders Association with promoting skilled trades education in high schools. Local high schools currently implement the Building Industry Technology Academy (BITA) curriculum, which has proven difficult for students to enroll in or complete. …

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Concentration Of Fecal Coliforms In Marine Waters Using Satellite Images In The Vicinity Of Pucusana. Bay, Peru., Y A. Palma-Gongora, F V. Zuta-Medina, Luis Angel Gomez-Cunya Jan 2022

Concentration Of Fecal Coliforms In Marine Waters Using Satellite Images In The Vicinity Of Pucusana. Bay, Peru., Y A. Palma-Gongora, F V. Zuta-Medina, Luis Angel Gomez-Cunya

Civil Engineering Faculty Publications

Water quality monitoring in coastal areas is challenging due to cost and time constraints. Identifying and selecting sampling sites accurately and effectively is crucial for efficient monitoring. The need for efficient monitoring of marine waters has led to exploring the use of remote sensing as one helpful alternative. Remote sensing is practical in several applications based on pattern recognition and information processing of large terrestrial and aquatic surface areas. Collected information is processed with various image processing techniques to identify objects such as microorganisms. Fecal coliforms are microorganisms that are indicators of sanitary quality and are present in human and …

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A Framework For Extension Studies Using Real-World Data To Examine Long-Term Safety And Effectiveness, Mehmet Burcu, Cyntia B Manzano-Salgado, Anne M Butler, Jennifer B Christian Jan 2022

A Framework For Extension Studies Using Real-World Data To Examine Long-Term Safety And Effectiveness, Mehmet Burcu, Cyntia B Manzano-Salgado, Anne M Butler, Jennifer B Christian

2020-Current year OA Pubs

Understanding the long-term benefits and risks of treatments, devices, and vaccines is critically important for individual- and population-level healthcare decision-making. Extension studies, or 'roll-over studies,' are studies that allow for patients participating in a parent clinical trial to 'roll-over' into a subsequent related study to continue to observe and measure long-term safety, tolerability, and/or effectiveness. These designs are not new and are often used as an approach to satisfy regulatory post-approval safety requirements. However, designs using traditional clinical trial infrastructure can be expensive and burdensome to conduct, particularly, when following patients for many years post trial completion. Given the increasing …

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Dermatologic Events Associated With The Anti-Ccr4 Antibody Mogamulizumab: Characterization And Management, Amy C M Musiek, Et Al. Jan 2022

Dermatologic Events Associated With The Anti-Ccr4 Antibody Mogamulizumab: Characterization And Management, Amy C M Musiek, Et Al.

2020-Current year OA Pubs

The CCR4-directed monoclonal antibody mogamulizumab has been shown to significantly improve progression-free survival and overall response rate compared with vorinostat in adults with relapsed/refractory mycosis fungoides (MF) and Sézary syndrome (SS). One of the most common adverse events seen with mogamulizumab in MF/SS patients is rash. Because of the protean nature of MF/SS and the variable clinical and histopathological features of mogamulizumab-associated rash, healthcare providers may have difficulty distinguishing rash from disease, and may not be aware of appropriate treatment strategies for this generally manageable adverse event. The objective of this report was to combine results from published literature with …

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Il-1 Reprogramming Of Adult Neural Stem Cells Limits Neurocognitive Recovery After Viral Encephalitis By Maintaining A Proinflammatory State, Allison L Soung, Veronica A Davé, Charise Garber, Eric D Tycksen, Lauren L Vollmer, Robyn S Klein Jan 2022

Il-1 Reprogramming Of Adult Neural Stem Cells Limits Neurocognitive Recovery After Viral Encephalitis By Maintaining A Proinflammatory State, Allison L Soung, Veronica A Davé, Charise Garber, Eric D Tycksen, Lauren L Vollmer, Robyn S Klein

2020-Current year OA Pubs

Innate immune responses to emerging RNA viruses are increasingly recognized as having significant contributions to neurologic sequelae, especially memory disorders. Using a recovery model of West Nile virus (WNV) encephalitis, we show that, while macrophages deliver the antiviral and anti-neurogenic cytokine IL-1β during acute infection; viral recovery is associated with continued astrocyte inflammasome-mediated production of inflammatory levels of IL-1β, which is maintained by hippocampal astrogenesis via IL-1R1 signaling in neural stem cells (NSC). Accordingly, aberrant astrogenesis is prevented in the absence of IL-1 signaling in NSC, indicating that only newly generated astrocytes exert neurotoxic effects, preventing synapse repair and promoting …

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Genome-Wide Analysis Of Mitochondrial Dna Copy Number Reveals Loci Implicated In Nucleotide Metabolism, Platelet Activation, And Megakaryocyte Proliferation, R J Longchamps, Mary Feitosa, Mary Wojczynski, Aldi Kraja, Michael Province, Et Al. Jan 2022

Genome-Wide Analysis Of Mitochondrial Dna Copy Number Reveals Loci Implicated In Nucleotide Metabolism, Platelet Activation, And Megakaryocyte Proliferation, R J Longchamps, Mary Feitosa, Mary Wojczynski, Aldi Kraja, Michael Province, Et Al.

2020-Current year OA Pubs

Mitochondrial DNA copy number (mtDNA-CN) measured from blood specimens is a minimally invasive marker of mitochondrial function that exhibits both inter-individual and intercellular variation. To identify genes involved in regulating mitochondrial function, we performed a genome-wide association study (GWAS) in 465,809 White individuals from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank (UKB). We identified 133 SNPs with statistically significant, independent effects associated with mtDNA-CN across 100 loci. A combination of fine-mapping, variant annotation, and co-localization analyses was used to prioritize genes within each of the 133 independent sites. Putative causal genes …

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A Map Of Neurofilament Light Chain Species In Brain And Cerebrospinal Fluid And Alterations In Alzheimer's Disease, Melissa M Budelier, Yingxin He, Nicolas R Barthelemy, Hong Jiang, Yan Li, Ethan Park, Rachel L Henson, Suzanne E Schindler, David M Holtzman, Randall J Bateman Jan 2022

A Map Of Neurofilament Light Chain Species In Brain And Cerebrospinal Fluid And Alterations In Alzheimer's Disease, Melissa M Budelier, Yingxin He, Nicolas R Barthelemy, Hong Jiang, Yan Li, Ethan Park, Rachel L Henson, Suzanne E Schindler, David M Holtzman, Randall J Bateman

2020-Current year OA Pubs

Neurofilament light is a well-established marker of both acute and chronic neuronal damage and is increased in multiple neurodegenerative diseases. However, the protein is not well characterized in brain tissue or body fluids, and it is unknown what neurofilament light species are detected by commercial assays and whether additional species exist. We developed an immunoprecipitation-mass spectrometry assay using custom antibodies targeting various neurofilament light domains, including antibodies targeting Coil 1A/1B of the rod domain (HJ30.13), Coil 2B of the rod domain (HJ30.4) and the tail region (HJ30.11). We utilized our assay to characterize neurofilament light in brain tissue and CSF …

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Differentiating Amyloid Beta Spread In Autosomal Dominant And Sporadic Alzheimer's Disease, Elizabeth Levitis, Jacob W Vogel, Thomas Funck, Vladimir Hachinski, Serge Gauthier, Jonathan Vöglein, Johannes Levin, Brian A Gordon, Tammie Benzinger, Yasser Iturria-Medina, Alan C Evans, Dominantly Inherited Alzheimer Network, Alzheimer’S Disease Neuroimaging Initiative Jan 2022

Differentiating Amyloid Beta Spread In Autosomal Dominant And Sporadic Alzheimer's Disease, Elizabeth Levitis, Jacob W Vogel, Thomas Funck, Vladimir Hachinski, Serge Gauthier, Jonathan Vöglein, Johannes Levin, Brian A Gordon, Tammie Benzinger, Yasser Iturria-Medina, Alan C Evans, Dominantly Inherited Alzheimer Network, Alzheimer’S Disease Neuroimaging Initiative

2020-Current year OA Pubs

Amyloid-beta deposition is one of the hallmark pathologies in both sporadic Alzheimer's disease and autosomal-dominant Alzheimer's disease, the latter of which is caused by mutations in genes involved in amyloid-beta processing. Despite amyloid-beta deposition being a centrepiece to both sporadic Alzheimer's disease and autosomal-dominant Alzheimer's disease, some differences between these Alzheimer's disease subtypes have been observed with respect to the spatial pattern of amyloid-beta. Previous work has shown that the spatial pattern of amyloid-beta in individuals spanning the sporadic Alzheimer's disease spectrum can be reproduced with high accuracy using an epidemic spreading model which simulates the diffusion of amyloid-beta across …

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Responding To Sexual Abuse In Health Care: Development Of A Guide For Patients, Tristan Mcintosh, Heidi Walsh, Meredith Parsons, Erin D Solomon, Jessica Mozersky, James M Dubois Jan 2022

Responding To Sexual Abuse In Health Care: Development Of A Guide For Patients, Tristan Mcintosh, Heidi Walsh, Meredith Parsons, Erin D Solomon, Jessica Mozersky, James M Dubois

2020-Current year OA Pubs

This report details the development of a stakeholder- and evidence-informed online resource guide for patients that provides information to raise awareness about sexual abuse in health care, the value of chaperones, and options for responding to sexual abuse. The guide was developed to reflect lessons learned from 10 years of researching physician wrongdoing (ie, sexual violations, improper prescribing, and unnecessary invasive procedures), a 5-year National Institutes of Health-funded mixed-methods study of 280 cases of egregious wrongdoing in medicine, and an expert working group. Focus groups were conducted with 22 patients from diverse backgrounds to obtain feedback on the acceptability of …

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Spatially Resolved Stellar Spectroscopy Of The Ultra-Diffuse Galaxy Dragonfly 44. Iii. Evidence For An Unexpected Star Formation History Under Conventional Galaxy Evolution Processes, Alexa Villaume, Aaron J. Romanowsky, Jean Brodie, Pieter Van Dokkum, Charlie Conroy, Duncan A. Forbes, Shany Danieli, Christopher Martin, Matt Matuszewski Jan 2022

Spatially Resolved Stellar Spectroscopy Of The Ultra-Diffuse Galaxy Dragonfly 44. Iii. Evidence For An Unexpected Star Formation History Under Conventional Galaxy Evolution Processes, Alexa Villaume, Aaron J. Romanowsky, Jean Brodie, Pieter Van Dokkum, Charlie Conroy, Duncan A. Forbes, Shany Danieli, Christopher Martin, Matt Matuszewski

Faculty Research, Scholarly, and Creative Activity

We use the Keck Cosmic Web Imager integral field unit spectrograph to (1) measure the global stellar population parameters for the ultra-diffuse galaxy (UDG) Dragonfly 44 (DF44) to much higher precision than previously possible for any UDG and (2) for the first time measure spatially resolved stellar population parameters of a UDG. We find that DF44 falls below the mass-metallicity relation established by canonical dwarf galaxies both in and beyond the Local Group. We measure a flat radial age gradient ( log Gyr kpc-1) and a flat to positive metallicity gradient ( dex kpc-1), which are inconsistent with the gradients …

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Discrimination Experiences During Covid-19 Among A National, Multi-Lingual, Community-Based Sample Of Asian Americans And Pacific Islanders: Compass Findings, Van M. Ta Park, Marcelle M. Dougan, Oanh L. Meyer, Bora Nam, Marian Tzuang, Linda G. Park, Quyen Vuong, Joon Bang, Janice Y. Tsoh Jan 2022

Discrimination Experiences During Covid-19 Among A National, Multi-Lingual, Community-Based Sample Of Asian Americans And Pacific Islanders: Compass Findings, Van M. Ta Park, Marcelle M. Dougan, Oanh L. Meyer, Bora Nam, Marian Tzuang, Linda G. Park, Quyen Vuong, Joon Bang, Janice Y. Tsoh

Faculty Research, Scholarly, and Creative Activity

Reports of escalated discrimination among Asian Americans and Pacific Islanders (AAPIs) due to COVID-19 are alarming, making this a public health priority. However, there are limited empirical studies on the scope and impact of COVID-19-related discrimination among AAPIs. Using the COVID-19 Effects on the Mental and Physical Health of AAPI Survey Study (COMPASS) data (N = 4971; survey period: October 2020–February 2021), which is a U.S.-wide multi-lingual survey, we examined the prevalence of, and factors associated with discrimination experiences attributable to being an AAPI during the COVID-19 pandemic. Overall, 60.7% reported experiencing discrimination; the group prevalence ranged from 80.0% (Hmong) …

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Evaluating The Implementation Of A Multi-Level Mhealth Study To Improve Hydroxyurea Utilization In Sickle Cell Disease, J S Hankins, A A King, A A Baumann, L M. Klesges, Et Al. Jan 2022

Evaluating The Implementation Of A Multi-Level Mhealth Study To Improve Hydroxyurea Utilization In Sickle Cell Disease, J S Hankins, A A King, A A Baumann, L M. Klesges, Et Al.

2020-Current year OA Pubs

BACKGROUND: Sickle Cell Disease (SCD) is a progressive genetic disease that causes organ damage and reduces longevity. Hydroxyurea is an underutilized evidence-based medication that reduces complications and improves survival in SCD. In a multi-site clinical trial, part of the NIH-funded Sickle Cell Disease Implementation Consortium (SCDIC), we evaluate the implementation of a multi-level and multi-component mobile health (mHealth) patient and provider intervention to target the determinants and context of low hydroxyurea use. Given the complexity of the intervention and contextual variability in its implementation, we combined different behavioral and implementation theories, models, and frameworks to facilitate the evaluation of the …

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Spanish-Speaking Caregivers’ Use Of Referential Labels With Toddlers Is A Better Predictor Of Later Vocabulary Than Their Use Of Referential Gestures, Janet Y. Bang, Manuel Bohn, Joel Ramírez, Virginia A. Marchman, Anne Fernald Jan 2022

Spanish-Speaking Caregivers’ Use Of Referential Labels With Toddlers Is A Better Predictor Of Later Vocabulary Than Their Use Of Referential Gestures, Janet Y. Bang, Manuel Bohn, Joel Ramírez, Virginia A. Marchman, Anne Fernald

Faculty Research, Scholarly, and Creative Activity

Variation in how frequently caregivers engage with their children is associated with variation in children's later language outcomes. One explanation for this link is that caregivers use both verbal behaviors, such as labels, and non-verbal behaviors, such as gestures, to help children establish reference to objects or events in the world. However, few studies have directly explored whether language outcomes are more strongly associated with referential behaviors that are expressed verbally, such as labels, or non-verbally, such as gestures, or whether both are equally predictive. Here, we observed caregivers from 42 Spanish-speaking families in the US engage with their 18-month-old …

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Robustness Of Image-Based Malware Analysis, Katrina Tran, Fabio Di Troia, Mark Stamp Jan 2022

Robustness Of Image-Based Malware Analysis, Katrina Tran, Fabio Di Troia, Mark Stamp

Faculty Research, Scholarly, and Creative Activity

In previous work, “gist descriptor” features extracted from images have been used in malware classification problems and have shown promising results. In this research, we determine whether gist descriptors are robust with respect to malware obfuscation techniques, as compared to Convolutional Neural Networks (CNN) trained directly on malware images. Using the Python Image Library (PIL), we create images from malware executables and from malware that we obfuscate. We conduct experiments to compare classifying these images with a CNN as opposed to extracting the gist descriptor features from these images to use in classification. For the gist descriptors, we consider a …

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Fake Malware Generation Using Hmm And Gan, Harshit Trehan, Fabio Di Troia Jan 2022

Fake Malware Generation Using Hmm And Gan, Harshit Trehan, Fabio Di Troia

Faculty Research, Scholarly, and Creative Activity

In the past decade, the number of malware attacks have grown considerably and, more importantly, evolved. Many researchers have successfully integrated state-of-the-art machine learning techniques to combat this ever present and rising threat to information security. However, the lack of enough data to appropriately train these machine learning models is one big challenge that is still present. Generative modelling has proven to be very efficient at generating image-like synthesized data that can match the actual data distribution. In this paper, we aim to generate malware samples as opcode sequences and attempt to differentiate them from the real ones with the …

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Crowdfunding Non-Fungible Tokens On The Blockchain, Sean Basu, Kimaya Basu, Thomas H. Austin Jan 2022

Crowdfunding Non-Fungible Tokens On The Blockchain, Sean Basu, Kimaya Basu, Thomas H. Austin

Faculty Research, Scholarly, and Creative Activity

Non-fungible tokens (NFTs) have been used as a way of rewarding content creators. Artists publish their works on the blockchain as NFTs, which they can then sell. The buyer of an NFT then holds ownership of a unique digital asset, which can be resold in much the same way that real-world art collectors might trade paintings. However, while a deal of effort has been spent on selling works of art on the blockchain, very little attention has been paid to using the blockchain as a means of fundraising to help finance the artist’s work in the first place. Additionally, while …

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Blackcurrants: A Nutrient-Rich Source For The Development Of Functional Foods For Improved Athletic Performance, Ali Ali Redha, Shahida Anusha Siddiqui, Reza Zare, Daniele Spadaccini, Silvia Guazzotti, Xi Feng, Nur Alim Bahmid, Yuan Seng Wu, Fathima Zahraa Ozeer, Rotimi E. Aluko Jan 2022

Blackcurrants: A Nutrient-Rich Source For The Development Of Functional Foods For Improved Athletic Performance, Ali Ali Redha, Shahida Anusha Siddiqui, Reza Zare, Daniele Spadaccini, Silvia Guazzotti, Xi Feng, Nur Alim Bahmid, Yuan Seng Wu, Fathima Zahraa Ozeer, Rotimi E. Aluko

Faculty Research, Scholarly, and Creative Activity

Blackcurrants are nutrient-rich fruits with a significant amount of bioactive compounds including vitamin C and polyphenols, especially anthocyanins. The high phytochemical content of blackcurrants promotes this fruit to become a valuable functional food ingredient with varying health-promoting activities targeting different consumers including athletes. Athletes experience oxidative stress during intense exercise, which can result in inflammation and reduced exercise performance. Antioxidants such as vitamin C and polyphenols can restore the regular oxidative status of the body. Blackcurrant supplementation has shown potential ergogenic activity to improve athlete performance during high-intensity training. Clinical trials have evaluated the effectiveness of blackcurrant supplementation on exercise …

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Characterizing The Feedback That Learning Assistants Give To Faculty, Sadhana Indukuri, Gina M. Quan Jan 2022

Characterizing The Feedback That Learning Assistants Give To Faculty, Sadhana Indukuri, Gina M. Quan

Faculty Research, Scholarly, and Creative Activity

Learning assistants are undergraduate peer educators that help facilitate learning in a university classroom environment. Jardine (2019) found that learning assistant feedback to faculty roughly fell into three categories: course logistics, student behavior, and student understanding. We built from this previous work by further characterizing the feedback given to faculty by learning assistants and found the following categories: student experience, classroom content, classroom structure, accessibility, empathy, and broad feedback. Using interview data with learning assistants and faculty working with learning assistants, we created a preliminary framework for the types of feedback and examples by learning assistants. This framework may be …

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Leveraging Hispanic-Serving Institutions Within Physics Education Research, Brianne Gutmann, Rebecca Rosenblatt Jan 2022

Leveraging Hispanic-Serving Institutions Within Physics Education Research, Brianne Gutmann, Rebecca Rosenblatt

Faculty Research, Scholarly, and Creative Activity

Hispanic serving institutions (HSIs) are an increasingly large set of higher education institutions in the United States. From 2010-2020 the number of HSIs increased from 311 to 569. Within the physics education research (PER) community, research perspectives from HSIs have provided critical insights into how to support racially and ethnically diverse students. Within the last decade, research from HSIs made up approximately 20% of publications from US higher education institutions in common PER journals. These publications do not always fully name and leverage their HSI context, though the work done at HSIs still more consistently centers students’ identities as compared …

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Abortion Attempts Without Clinical Supervision Among Transgender, Nonbinary And Gender-Expansive People In The United States, Heidi Moseson, Laura Fix, Caitlin Gerdts, Sachiko Ragosta, Jen Hastings, Ari Stoeffler, Eli A. Goldberg, Mitchell R. Lunn, Annesa Flentje, Matthew R. Capriotti, Micah E. Lubensky, Juno Obedin-Maliver Jan 2022

Abortion Attempts Without Clinical Supervision Among Transgender, Nonbinary And Gender-Expansive People In The United States, Heidi Moseson, Laura Fix, Caitlin Gerdts, Sachiko Ragosta, Jen Hastings, Ari Stoeffler, Eli A. Goldberg, Mitchell R. Lunn, Annesa Flentje, Matthew R. Capriotti, Micah E. Lubensky, Juno Obedin-Maliver

Faculty Research, Scholarly, and Creative Activity

Background Transgender, nonbinary and gender-expansive (TGE) people face barriers to abortion care and may consider abortion without clinical supervision. Methods In 2019, we recruited participants for an online survey about sexual and reproductive health. Eligible participants were TGE people assigned female or intersex at birth, 18 years and older, from across the United States, and recruited through The PRIDE Study or via online and in-person postings. Results Of 1694 TGE participants, 76 people (36% of those ever pregnant) reported considering trying to end a pregnancy on their own without clinical supervision, and a subset of these (n=40; 19% of those …

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Mapping Emotional Attachment As A Measure Of Sense Of Place To Identify Coastal Restoration Priority Areas, Timothy L. Hawthorne, Kayla R. Toohy, Bo Yang, Lain Graham, Elise M. Lorenzo, Hannah Torres, Morgan Mcdonald, Fernando Rivera, Kirsten Bouck, Linda J. Walters Jan 2022

Mapping Emotional Attachment As A Measure Of Sense Of Place To Identify Coastal Restoration Priority Areas, Timothy L. Hawthorne, Kayla R. Toohy, Bo Yang, Lain Graham, Elise M. Lorenzo, Hannah Torres, Morgan Mcdonald, Fernando Rivera, Kirsten Bouck, Linda J. Walters

Faculty Research, Scholarly, and Creative Activity

Our applied case study demonstrates how knowledge from community stakeholders about emotional attachment (as a key component of sense of place) can inform and influence future coastal restoration priorities at various scales in the Indian River Lagoon, Florida (USA). We map aggregate measures of emotional attachment from community stakeholders using Geographic Information Systems. We then analyze this human systems level data with kernel density estimation measures at the broader lagoon scale and with inverse distance weighted measures at more localized scales. By connecting these mapped results back to the primary reasons that participants provided for having high or low emotional …

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Design, Construction And Operation Of The Protodune-Sp Liquid Argon Tpc, A. Abed Abud, B. Abi, R. Acciarri, M. A. Acero, M. R. Adames, G. Adamov, D. Adams, M. Adinolfi, A. Aduszkiewicz, J. Aguilar, Z. Ahmad, J. Ahmed, B. Ali-Mohammadzadeh, T. Alion, K. Allison, S. Alonso Monsalve, M. Alrashed, Athanasios Hatzikoutelis, For Full Author List, See Comments Below Jan 2022

Design, Construction And Operation Of The Protodune-Sp Liquid Argon Tpc, A. Abed Abud, B. Abi, R. Acciarri, M. A. Acero, M. R. Adames, G. Adamov, D. Adams, M. Adinolfi, A. Aduszkiewicz, J. Aguilar, Z. Ahmad, J. Ahmed, B. Ali-Mohammadzadeh, T. Alion, K. Allison, S. Alonso Monsalve, M. Alrashed, Athanasios Hatzikoutelis, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

The ProtoDUNE-SP detector is a single-phase liquid argon time projection chamber (LArTPC) that was constructed and operated in the CERN North Area at the end of the H4 beamline. This detector is a prototype for the first far detector module of the Deep Underground Neutrino Experiment (DUNE), which will be constructed at the Sandford Underground Research Facility (SURF) in Lead, South Dakota, U.S.A. The ProtoDUNE-SP detector incorporates full-size components as designed for DUNE and has an active volume of 7 × 6 × 7.2 m3. The H4 beam delivers incident particles with well-measured momenta and high-purity particle identification. ProtoDUNE-SP's successful …

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A Blockchain-Based Retribution Mechanism For Collaborative Intrusion Detection, Wenjun Fan, Shubham Kumar, Sang Yoon Chang, Younghee Park Jan 2022

A Blockchain-Based Retribution Mechanism For Collaborative Intrusion Detection, Wenjun Fan, Shubham Kumar, Sang Yoon Chang, Younghee Park

Faculty Research, Scholarly, and Creative Activity

Collaborative intrusion detection approach uses the shared detection signature between the collaborative participants to facilitate coordinated defense. In the context of collaborative intrusion detection system (CIDS), however, there is no research focusing on the efficiency of the shared detection signature. The inefficient detection signature costs not only the IDS resource but also the process of the peer-to-peer (P2P) network. In this paper, we therefore propose a blockchain-based retribution mechanism, which aims to incentivize the participants to contribute to verifying the efficiency of the detection signature in terms of certain distributed consensus. We implement a prototype using Ethereum blockchain, which instantiates …

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Tracking The Functions Of Ai As Paradata & Pursuing Archival Accountability, Jeremy Davet, Babak Hamidzadeh, Patricia Franks, Jenny Bunn Jan 2022

Tracking The Functions Of Ai As Paradata & Pursuing Archival Accountability, Jeremy Davet, Babak Hamidzadeh, Patricia Franks, Jenny Bunn

Faculty Research, Scholarly, and Creative Activity

While a familiar term in fields like social science research and digital cultural heritage, 'paradata' has not yet been introduced conceptually into the archival realm. In response to an increasing number of experiments with machine learning and artificial intelligence, the InterPARES Trust AI research group proposes the definition of paradata as 'information about the procedure(s) and tools used to create and process information resources, along with information about the persons carrying out those procedures.' The utilization of this concept in archives can help to ensure that AI-driven systems are designed from the outset to honor the archival ethic, and to …

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Defining The Role Of Axl In Metastatic Prostate Cancer, Anastasia Bernal, Borum Ryu, Grinu Mathew Jan 2022

Defining The Role Of Axl In Metastatic Prostate Cancer, Anastasia Bernal, Borum Ryu, Grinu Mathew

Posters: 2022 Summer Undergraduate Research Program

Prostate cancer (PC) is the second leading cause of death due to cancer among men in the United States. Metastatic disease is commonly seen in sites such as lymph nodes, bone and in visceral organs like lung and liver. The 5 year survival rate of patients with primary PC is almost 100%, however, this survival rate is drastically reduced to 30% in patients with metastatic disease. Therefore there is an unmet need to identify genes associated with metastatic progression and develop therapeutic strategies to increase survival rate in patients with aggressive disease. The loss of TAM kinase family receptor AXL …

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Analysis Of Covid-19 Pandemic Disease Metrics In Nebraska Counties With Large Meat Processing Plants, Nyah D. Chambers, James Lawler Md,Mph, Sara Donovan Mph Jan 2022

Analysis Of Covid-19 Pandemic Disease Metrics In Nebraska Counties With Large Meat Processing Plants, Nyah D. Chambers, James Lawler Md,Mph, Sara Donovan Mph

Posters: 2022 Summer Undergraduate Research Program

This poster analyzes COVID-19 disease metrics of counties with large meat processing facilities to counties with small or no meat processing facilities based on different time frames of the COVID-19 pandemic.

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Modeling Nonsegmented Negative-Strand Rna Virus (Nnsv) Transcription With Ejective Polymerase Collisions And Biased Diffusion, Felipe-Andrés Piedra, David Henke, Anubama Rajan, Donna M Muzny, Harsha Doddapaneni, Vipin K Menon, Kristi L Hoffman, Matthew C Ross, Sara J Javornik Cregeen, Ginger Metcalf, Richard A Gibbs, Joseph F Petrosino, Vasanthi Avadhanula, Pedro A Piedra Jan 2022

Modeling Nonsegmented Negative-Strand Rna Virus (Nnsv) Transcription With Ejective Polymerase Collisions And Biased Diffusion, Felipe-Andrés Piedra, David Henke, Anubama Rajan, Donna M Muzny, Harsha Doddapaneni, Vipin K Menon, Kristi L Hoffman, Matthew C Ross, Sara J Javornik Cregeen, Ginger Metcalf, Richard A Gibbs, Joseph F Petrosino, Vasanthi Avadhanula, Pedro A Piedra

Faculty, Staff and Students Publications

Infections by non-segmented negative-strand RNA viruses (NNSV) are widely thought to entail gradient gene expression from the well-established existence of a single promoter at the 3' end of the viral genome and the assumption of constant transcriptional attenuation between genes. But multiple recent studies show viral mRNA levels in infections by respiratory syncytial virus (RSV), a major human pathogen and member of NNSV, that are inconsistent with a simple gradient. Here we integrate known and newly predicted phenomena into a biophysically reasonable model of NNSV transcription. Our model succeeds in capturing published observations of respiratory syncytial virus and vesicular stomatitis …

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Whole Lung Lavage: Treating Pulmonary Alveolar Proteinosis At The Time Of Covid Pandemic, Katherine Jean Powers, Vasanthi Avadhanula, Purvesh R Patel, Pralay Kumar Sarkar, Pedro Piedra, Neda Zarrin-Khameh Jan 2022

Whole Lung Lavage: Treating Pulmonary Alveolar Proteinosis At The Time Of Covid Pandemic, Katherine Jean Powers, Vasanthi Avadhanula, Purvesh R Patel, Pralay Kumar Sarkar, Pedro Piedra, Neda Zarrin-Khameh

Faculty, Staff and Students Publications

Pulmonary alveolar proteinosis (PAP) is a rare syndrome due to increased production or decreased clearance of surfactant in alveoli and terminal bronchi that cause hypoxemic respiratory insufficiency. Here we present a patient with PAP whose disease was exacerbated by superimposed COVID-19 pneumonia. He underwent whole lung lavage (WLL). Evaluation of the viral count of the first and the last lavage of the left lung showed viral load in the alveolar space dropped by approximately 10-folds, however the magnitude of the viral load was substantial in both lavage samples. Whole pulmonary lavage may be used as a treatment option on patients …

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