Digital Commons Network^™

Modelling Of Convection, Diffusion And Binding Of Chlorides In Concrete During Wetting-Drying Cycles, Long-Yuan Li, Dawang Li, Ping Li, Yao-Cheng Wang

School of Engineering, Computing and Mathematics

Moisture convection in concrete is an important factor affecting the chloride diffusion in concrete. This paper presents a comprehensive study on the transport of moisture, carbon dioxide and chloride ions in concrete when subjected to wetting and drying cycles. A numerical model considering not only the transport of individual components but also the interaction between them is developed. The latter includes the concrete carbonation, chloride binding, the effect of concrete carbonation on chloride binding capacity, and the time-varying boundary conditions of carbon dioxide and chloride caused due to wetting and/or drying. The results obtained from the study demonstrate that when …

Towards A New Methodology For The Characterisation Of Crack Tip Fields Based On A Hybrid Computational Approach, A Camacho-Reyes, Jm Vasco-Olmo, Mn James, Fa Diaz

School of Engineering, Computing and Mathematics

No abstract provided.

The Importance Of The Job Role In Social Media Cybersecurity Training, Salamah F Ben, Ma Palomino, M Papadaki, S Furnell

School of Engineering, Computing and Mathematics

No abstract provided.

Embrittlement Failure Of 51crv4 Leaf Springs, Mn James, Dg Hattingh, L Matthews

School of Engineering, Computing and Mathematics

High strength quenched and tempered alloys are used in the manufacture of leaf springs, and peening techniques are used to induce compressive residual stresses on the tension surface of the individual leaves to resist fatigue crack growth. However, the extent of such residual stresses is usually limited to around 0.1–0.2 mm deep. Their beneficial effect can therefore be negated by corrosion pitting, while high strength steels are known to also be susceptible to environmental embrittlement in high chloride environments. This case study deals with an interesting example of environmental embrittlement of multileaf springs reportedly made from 60Si2Mn steel, but actually …

Analysis Of Electrical Conductivity Of Carbon Nanotube-Reinforced Two-Phase Composites, Z Li, L-Y Li

School of Engineering, Computing and Mathematics

No abstract provided.

Surface Quality Augmentation For Metalworking Industry With Pix2pix, Dirk Hölscher, Christoph Reich, Martin Knahl, Frank Gut, Nathan Clarke

School of Engineering, Computing and Mathematics

No abstract provided.

The Numerical Re-Creation Of Experimentally Generated Nonlinear Irregular Wave Fields Using A Time-Reversal Approach, S. Draycott, P. K. Stansby, M. L. Mcallister, T. Davey, L. Jordan, T. Tosdevin, M. Hann

School of Engineering, Computing and Mathematics

Physical model testing in irregular waves is often used to assess performance, and validate numerical models, of offshore structures and platforms, yet the full phase-resolved experimental conditions including reflections and correct nonlinearity are seldom replicated numerically. This results in uncertainty in numerical model validation, particularly when considering extremes. Herein we assess a time-reversal approach for the accurate numerical replication of experimentally generated wave fields. Fifteen irregular sea states, including steep and breaking cases, are generated in two large laboratories in the UK and replicated numerically using the time-domain nonlinear potential flow code OceanWave3D. Through statistical, temporal, and spatial analysis, the …

An Evaluation Of The Seagrass Walk, An Immersive Living Arts Piece Installed At The National Marine Aquarium, Plymouth, Uk. A Report Funded By The Green Minds Project, S Rees, A Morgan, C Parrott

School of Biological and Marine Sciences

No abstract provided.

An Exploration Of The Contribution Of Embodied, Situated Research Strategies To Cultural Ecosystem Services And Landscape Assessment Frameworks: An Environmental Empathy Case Study, K Łucznik, Jv Serrano, J Martin

School of Geography, Earth and Environmental Sciences

Since the Millennium Ecosystem Assessment in 2005, interest has increased in cultural ecosystem services (CESs) research to understand the complexity of the non-material benefits that people obtain from ecosystems. The intangible and interactive characteris-tics of CESs present many challenges regarding how to approach, quantify and even de-fine CESs. In this paper, we suggest looking at CESs through the lens of embodied and situated cognition theories. We advocate that such an approach should be applied to the development stage of CES research projects, as the embodied and situated experience of the site aids the development of research questions and future interventions. …

Posc289 Cost-Effectiveness Of Vagus Nerve Stimulation With Anti-Seizure Medication Versus Anti-Seizure Medication Alone In The Management Of Drug Resistant Epilepsy In England, C Raspin, Rohit Shankar, Francesca Barion, V Pollit, Joanna Murphy, L Sawyer, Vanessa Danielson

Peninsula Medical School

ObjectivesTo estimate the cost-effectiveness of vagus nerve stimulation (VNS) as an adjunctive therapy to anti-seizure medication (ASMs) when compared with a strategy of ASMs alone for the management of drug resistant epilepsy (DRE).MethodsA five health state cohort transition model was developed, with a 10-year time horizon, a 3-month cycle length and an English National Health Service perspective. Health states were defined by a percentage reduction in seizure frequency and aligned with randomised trial data informing the first cycle transition probabilities. Thereafter, non-VNS patients remained in state, while a systematic literature review informed further VNS patient transitions up to year 2, …

“What Works” Registries Of Interventions To Improve Child And Youth Psychosocial Outcomes: A Critical Appraisal, Nick Axford, Louise Morpeth, Gretchen Bjornstad, Tim Hobbs, Vashti Berry

Peninsula Medical School

The last decade or more has seen a proliferation of online registries of evidence-based interventions designed to improve child and youth psychosocial outcomes. The purpose of these resources is typically to help decision-makers make sense of the evidence and thereby inform their decision-making about investment in interventions. Most registries are underpinned by standards of evidence, which are used to guide the rating of programs by a panel of experts. While supporters extol the influence of these initiatives in terms of making commissioners more discriminating about what they invest in, detractors contend that they stifle innovation and embody an unduly narrow …

Il-1 Reprogramming Of Adult Neural Stem Cells Limits Neurocognitive Recovery After Viral Encephalitis By Maintaining A Proinflammatory State, Allison L Soung, Veronica A Davé, Charise Garber, Eric D Tycksen, Lauren L Vollmer, Robyn S Klein

2020-Current year OA Pubs

Innate immune responses to emerging RNA viruses are increasingly recognized as having significant contributions to neurologic sequelae, especially memory disorders. Using a recovery model of West Nile virus (WNV) encephalitis, we show that, while macrophages deliver the antiviral and anti-neurogenic cytokine IL-1β during acute infection; viral recovery is associated with continued astrocyte inflammasome-mediated production of inflammatory levels of IL-1β, which is maintained by hippocampal astrogenesis via IL-1R1 signaling in neural stem cells (NSC). Accordingly, aberrant astrogenesis is prevented in the absence of IL-1 signaling in NSC, indicating that only newly generated astrocytes exert neurotoxic effects, preventing synapse repair and promoting …

Genome-Wide Analysis Of Mitochondrial Dna Copy Number Reveals Loci Implicated In Nucleotide Metabolism, Platelet Activation, And Megakaryocyte Proliferation, R J Longchamps, Mary Feitosa, Mary Wojczynski, Aldi Kraja, Michael Province, Et Al.

2020-Current year OA Pubs

Mitochondrial DNA copy number (mtDNA-CN) measured from blood specimens is a minimally invasive marker of mitochondrial function that exhibits both inter-individual and intercellular variation. To identify genes involved in regulating mitochondrial function, we performed a genome-wide association study (GWAS) in 465,809 White individuals from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank (UKB). We identified 133 SNPs with statistically significant, independent effects associated with mtDNA-CN across 100 loci. A combination of fine-mapping, variant annotation, and co-localization analyses was used to prioritize genes within each of the 133 independent sites. Putative causal genes …

A Phase 1b Study Of Telisotuzumab Vedotin In Combination With Nivolumab In Patients With Nsclc, D Ross Camidge, Daniel Morgensztern, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Telisotuzumab vedotin (Teliso-V) is an anti-c-Met-directed antibody-drug conjugate that has exhibited antitumor activity as monotherapy in NSCLC. Its potential activity combined with programmed cell death protein-1 inhibitors has not been previously evaluated.

METHODS: In a phase 1b study (NCT02099058), adult patients (≥18 y) with advanced NSCLC received combination therapy with Teliso-V (1.6, 1.9, or 2.2 mg/kg, every 2 wk) plus nivolumab (3 mg/kg, 240 mg, or per locally approved label). The primary objective was to assess safety and tolerability; secondary objectives included the evaluation of antitumor activity.

RESULTS: As of January 2020, a total of 37 patients received treatment …

Toolkit Of Methods For Feminist Participatory Action Research: Empowering Women, Transforming Systems, Trimita Chakma, Naomi Joy Godden, Kavita Naidu

Research outputs 2022 to 2026

This Toolkit was developed following a series of training workshops on Feminist Participatory Action Research (FPAR) concepts and methods with Oxfam Cambodia’s Inclusion Project 2 (IP2) partners from Lao, Myanmar, Cambodia, Thailand and Vietnam. The training provided targeted capacity support and technical assistance to the IP2 partners to develop gender-responsive advocacy activities on water governance in the Mekong region.

This Toolkit was developed to provide guidance to IP2 partners on how to use FPAR methods in their ongoing activities and advocacy. However, FPAR is a process and is not issue-specific. As such, the Toolkit can also be used by communities, …

The Art Of Poetry And Its Place In The History Of The Coordinating Research Councils Real World Emissions Workshop {Poster}, Gary A. Bishop

Fuel Efficiency Automobile Test Publications

No abstract provided.

A Privacy Preserving Online Learning Framework For Medical Diagnosis Applications, Trang Pham Ngoc Nguyen

Theses: Doctorates and Masters

Electronic Health records are an important part of a digital healthcare system. Due to their significance, electronic health records have become a major target for hackers, and hospitals/clinics prefer to keep the records at local sites protected by adequate security measures. This introduces challenges in sharing health records. Sharing health records however, is critical in building an accurate online diagnosis framework. Most local sites have small data sets, and machine learning models developed locally based on small data sets, do not have knowledge about other data sets and learning models used at other sites.

The work in this thesis utilizes …

Computer Vision Based Classification Of Fruits And Vegetables For Self-Checkout At Supermarkets, Khurram Hameed

Theses: Doctorates and Masters

The field of machine learning, and, in particular, methods to improve the capability of machines to perform a wider variety of generalised tasks are among the most rapidly growing research areas in today’s world. The current applications of machine learning and artificial intelligence can be divided into many significant fields namely computer vision, data sciences, real time analytics and Natural Language Processing (NLP). All these applications are being used to help computer based systems to operate more usefully in everyday contexts. Computer vision research is currently active in a wide range of areas such as the development of autonomous vehicles, …

An Exploration Of Octatonicism: From Liszt To Takemitsu, Yagan M. Kiely

Theses: Doctorates and Masters

The octatonic pitch set can be found in the works of many composers since the early nineteenth century, often with different characteristics of the pitch set being exploited by the composers. Much of the literature on octatonicism relates to specific instances in compositions or a specific composer’s approach to it rather than exploring octatonicism from a more holistic perspective. This dissertation serves as a holistic resource for the characteristics of the octatonic pitch set; whether as a scale, especially with regards to common practice harmony; or an unordered set. It does this by considering the contextual historical implications of the …

Aliwa! A Reimagined Journey: A Stage Play And Exploring A Nyoongar Theatre Text With Pre-Service Teachers: An Exegesis, Elisa M. Williams

Theses: Doctorates and Masters

Australia is home to one of the oldest continuous living cultures in the world. Now, more so than ever before, government and educational bodies are recognising the importance of integrating Indigenous cultures in education as a means of promoting intercultural understanding and improving educational outcomes for Indigenous students. The Australian Curriculum has advocated that Indigenous histories and cultures be embedded into every subject rather than taught separately. Drama is a curriculum area that provides many opportunities to integrate learning about Indigenous perspectives by exploring historically and culturally rich Indigenous theatre texts. Research is showing that non-Indigenous teachers are avoiding this …

Yoga Therapy During Chemotherapy For Early-Stage And Locally Advanced Breast Cancer, Samantha K Greaney, Neha Amin, Bethany C Prudner, Maggie Compernolle, Linda J Sandell, Susan C Tebb, Katherine N Weilbaecher, Peri Abeln, Jingqin Luo, Yu Tao, Angela C Hirbe, Lindsay L Peterson

2020-Current year OA Pubs

BACKGROUND: Chemotherapy is associated with decreased quality of life (QOL), fatigue, depression, and weight gain in patients with breast cancer. Weight gain is associated with poorer prognosis. Yoga improves QOL, fatigue, and mood in women with breast cancer but its effect on treatment-related weight gain has not been studied. The aim of this trial was to determine the feasibility of personalized yoga therapy in women receiving treatment for early-stage or locally advanced breast cancer and assess its impact on weight gain.

METHODS: Thirty women were randomized 1:1 to receive yoga therapy by a certified yoga therapist during treatment or a …

Modifications To Student Quarantine Policies In K-12 Schools Implementing Multiple Covid-19 Prevention Strategies Restores In-Person Education Without Increasing Sars-Cov-2 Transmission Risk, January-March 2021, Patrick Dawson, Sara Malone, Stephanie A. Fritz, Brock K. Montgomery, Mary Boyle, Brett Maricque, Albert M. Lai, Julie A. Neidich, Rachel C. Orscheln, Jason G Newland, Et Al.

2020-Current year OA Pubs

OBJECTIVE: To determine whether modified K-12 student quarantine policies that allow some students to continue in-person education during their quarantine period increase schoolwide SARS-CoV-2 transmission risk following the increase in cases in winter 2020-2021.

METHODS: We conducted a prospective cohort study of COVID-19 cases and close contacts among students and staff (n = 65,621) in 103 Missouri public schools. Participants were offered free, saliva-based RT-PCR testing. The projected number of school-based transmission events among untested close contacts was extrapolated from the percentage of events detected among tested asymptomatic close contacts and summed with the number of detected events for a …

Detection Of Emerging Neurodegeneration Using Bayesian Linear Mixed-Effect Modeling, Yann Cobigo, Richard J Perrin, Et Al.

2020-Current year OA Pubs

Early detection of neurodegeneration, and prediction of when neurodegenerative diseases will lead to symptoms, are critical for developing and initiating disease modifying treatments for these disorders. While each neurodegenerative disease has a typical pattern of early changes in the brain, these disorders are heterogeneous, and early manifestations can vary greatly across people. Methods for detecting emerging neurodegeneration in any part of the brain are therefore needed. Prior publications have described the use of Bayesian linear mixed-effects (BLME) modeling for characterizing the trajectory of change across the brain in healthy controls and patients with neurodegenerative disease. Here, we use an extension …

All-Cause And In-Hospital Mortality After Aspirin Use In Patients Hospitalized With Covid-19: A Systematic Review And Meta-Analysis, Nischit Baral, Joshua D Mitchell, Pramod K Savarapu, Maxwell Akanbi, Bandana Acharya, Soumya Kambalapalli, Amith Seri, Krishna P Bashyal, Arvind Kunadi, Niranjan Ojha, Annabelle Santos Volgman, Tripti Gupta, Timir K Paul

2020-Current year OA Pubs

BACKGROUND: With the results of the largest randomized controlled trial (RECOVERY) and the most extensive retrospective cohort study on coronavirus disease 2019 (COVID-19) recently published, we performed a meta-analysis on the association of aspirin with mortality of COVID-19. We aimed to investigate the role of aspirin in COVID-19 hospitalizations.

MATERIALS AND METHODS: We searched PubMed, EMBASE and Cochrane databases for studies from 1 January 2020 until 20 July 2022, that compared aspirin versus non-aspirin use in hospitalized COVID-19 patients. We excluded case reports, review articles and studies on non-hospitalized COVID-19 infections. We used the inverse variance method and random effects …

The First 20 Months Of The Covid-19 Pandemic: Mortality, Intubation And Icu Rates Among 104,590 Patients Hospitalized At 21 United States Health Systems, Michael C. Fiore, Li-Shiun Chen, Et Al.

2020-Current year OA Pubs

MAIN OBJECTIVE: There is limited information on how patient outcomes have changed during the COVID-19 pandemic. This study characterizes changes in mortality, intubation, and ICU admission rates during the first 20 months of the pandemic.

STUDY DESIGN AND METHODS: University of Wisconsin researchers collected and harmonized electronic health record data from 1.1 million COVID-19 patients across 21 United States health systems from February 2020 through September 2021. The analysis comprised data from 104,590 adult hospitalized COVID-19 patients. Inclusion criteria for the analysis were: (1) age 18 years or older; (2) COVID-19 ICD-10 diagnosis during hospitalization and/or a positive COVID-19 PCR …

Inferring The Dynamical Effects Of Stroke Lesions Through Whole-Brain Modeling, Sebastian Idesis, Chiara Favaretto, Nicholas V Metcalf, Joseph C Griffis, Gordon L Shulman, Maurizio Corbetta, Gustavo Deco

2020-Current year OA Pubs

Understanding the effect of focal lesions (stroke) on brain structure-function traditionally relies on behavioral analyses and correlation with neuroimaging data. Here we use structural disconnection maps from individual lesions to derive a causal mechanistic generative whole-brain model able to explain both functional connectivity alterations and behavioral deficits induced by stroke. As compared to other models that use only the local lesion information, the similarity to the empirical fMRI connectivity increases when the widespread structural disconnection information is considered. The presented model classifies behavioral impairment severity with higher accuracy than other types of information (e.g.: functional connectivity). We assessed topological measures …

Neonatal Motor Functional Connectivity And Motor Outcomes At Age Two Years In Very Preterm Children With And Without High-Grade Brain Injury, Peppar E P Cyr, Rachel E Lean, Jeanette K Kenley, Sydney Kaplan, Dominique E Meyer, Jeffery J Neil, Dimitrios Alexopoulos, Rebecca G Brady, Joshua S Shimony, Thomas L Rodebaugh, Cynthia E Rogers, Christopher D Smyser

2020-Current year OA Pubs

Preterm-born children have high rates of motor impairments, but mechanisms for early identification remain limited. We hypothesized that neonatal motor system functional connectivity (FC) would relate to motor outcomes at age two years; currently, this relationship is not yet well-described in very preterm (VPT; born <32 weeks' gestation) infants with and without brain injury. We recruited 107 VPT infants - including 55 with brain injury (grade III-IV intraventricular hemorrhage, cystic periventricular leukomalacia, post-hemorrhagic hydrocephalus) - and collected FC data at/near term-equivalent age (35-45 weeks postmenstrual age). Correlation coefficients were used to calculate the FC between bilateral motor and visual cortices and thalami. At two years corrected-age, motor outcomes were assessed with the Bayley Scales of Infant and Toddler Development, 3rd edition. Multiple imputation was used to estimate missing data, and regression models related FC measures to motor outcomes. Within the brain-injured group only, interhemispheric motor cortex FC was positively related to gross motor outcomes. Thalamocortical and visual FC were not related to motor scores. This suggests neonatal alterations in motor system FC may provide prognostic information about impairments in children with brain injury.

Differentiating Amyloid Beta Spread In Autosomal Dominant And Sporadic Alzheimer's Disease, Elizabeth Levitis, Jacob W Vogel, Thomas Funck, Vladimir Hachinski, Serge Gauthier, Jonathan Vöglein, Johannes Levin, Brian A Gordon, Tammie Benzinger, Yasser Iturria-Medina, Alan C Evans, Dominantly Inherited Alzheimer Network, Alzheimer’S Disease Neuroimaging Initiative

2020-Current year OA Pubs

Amyloid-beta deposition is one of the hallmark pathologies in both sporadic Alzheimer's disease and autosomal-dominant Alzheimer's disease, the latter of which is caused by mutations in genes involved in amyloid-beta processing. Despite amyloid-beta deposition being a centrepiece to both sporadic Alzheimer's disease and autosomal-dominant Alzheimer's disease, some differences between these Alzheimer's disease subtypes have been observed with respect to the spatial pattern of amyloid-beta. Previous work has shown that the spatial pattern of amyloid-beta in individuals spanning the sporadic Alzheimer's disease spectrum can be reproduced with high accuracy using an epidemic spreading model which simulates the diffusion of amyloid-beta across …

Developing An Integrated Multilevel Model Of Uncertainty In Health Care: A Qualitative Systematic Review And Thematic Synthesis, Prashanti Eachempati, Roland Brian Büchter, Kiran Kumar Ks, Sally Hanks, John Martin, Mona Nasser

Peninsula Dental School

Introduction Uncertainty is an inevitable part of healthcare and a source of confusion and challenge to decision-making. Several taxonomies of uncertainty have been developed, but mainly focus on decisions in clinical settings. Our goal was to develop a holistic model of uncertainty that can be applied to both clinical as well as public and global health scenarios.Methods We searched Medline, Embase, CINAHL, Scopus and Google scholar in March 2021 for literature reviews, qualitative studies and case studies related to classifications or models of uncertainty in healthcare. Empirical articles were assessed for study limitations using the Critical Appraisal Skills Programme (CASP) …

Portfolio Optimisation Using Genetic Algorithms And Copula Financial Models, Tahani Alotaibi

School of Engineering, Computing and Mathematics Theses

Portfolio optimisation aims to efficiently find optimal proportions of portfolio assets, given certain constraints, and has been well-studied (Jin et al. 2016). While portfolio optimisation ascertains asset combinations most suited to investor requirements, numerous real-world problems impact its simplicity, e.g., investor preferences. Trading restrictions are also commonly faced, and must be met. However, in adding constraints to Markowitz’s basic mean-variance model, problem complexity increases, causing difficulties for exact optimisation approaches to find large problem solutions inside reasonable timeframes. The concern of this study concern is portfolio optimisation under three real-world constraints, using Markowitz’s mean-variance portfolio optimisation problem to obtain optimal …