Digital Commons Network^™

Tumor-Targeted Ph-Sensitive Manganese Oxide Nanoparticle For Enhanced Detection Of Breast Cancer Using Mri, Celia Martinez De La Torre

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the United States, approximately 287,850 new cases of invasive breast cancer will be diagnosed, and over 43,000 women will die because of it in 2022. Currently, mammography is the gold standard for breast cancer surveillance. Although this detection technique is relatively cheap and fast, it misses about 1 in 5 breast cancers in younger women with dense breast tissue, causing a delay in treatment. Compared to mammography, magnetic resonance imaging (MRI) has superior soft-tissue contrast that elucidates structural differences within soft tissue to detect more breast cancers. However, MRI still misses

NEMO particles were produced by synthesizing manganese oxide …

Developing Teaching Adaptability In Pre-Service Teachers Using Practice-Based Teacher Education, Kyuil Cho

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to examine how pre-service teachers (PSTs) develop their teaching adaptive competence through teaching rehearsal and repeated teaching, which is one of the focused teacher education strategies in practice-based teacher education (PBTE). This study was conducted in an introductory teaching methods course of a physical education teacher education (PETE) program. A total of 22 PSTs participated in the study. Fourteen were male, and eight were female. The PSTs had varied coaching experiences ranging from little to no coaching in limited recreational sports settings, and none had teaching or coaching experience in the school setting.

A …

The Business Of Behavior: Appalachian Teachers’ Experiences In Using Positive Behavior Interventions And Support, Erin Michele Coffield

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation explores the lived experiences of Appalachian elementary and middle school teachers who have been identified as working in Positive Behavior Intervention and Support (PBIS) schools. This study used Lifeworld Theory to engage in discussion about the teachers’ individual experiences in using PBIS in their classrooms in relation to resilience frameworks and childhood trauma. The teachers’ individual experiences were analyzed using a Whole-Part-Whole analysis to bring the individual stories together to better understand how PBIS and childhood trauma are experienced in a specific Appalachian school. Discussion opens up through the participants' experiences about grit models in school, trauma their …

Photophysics And Photochemistry Enabled By Ligand-To-Metal-Charge-Transfer: Unusual Carbon-Carbon Bond Formation At A Zirconium Center, P. Minh N. Do

Graduate Theses, Dissertations, and Problem Reports (ETD)

Six Group 4 metallocene derivatives of group 4 incorporating a redox active benzene-1,2-thiolate ligand (bdt) were prepared. These complexes were characterized using one- and two-dimensional nuclear magnetic resonance (NMR) spectroscopy. Additionally, X-ray crystallographic analyses of these complexes, with the exception of Cp₂Zrbdt (Cp = cyclopentadienyl), reveal C_2v symmetric structure in the solid-state. All species display electronic absorption bands that are ligand-to-metal charge transfer (LMCT) in character well into the visible region. Spectroscopic data combine with time dependent-density functional theory calculations showed fluctuation in solution which promotes non-radiative energy loss and leads to the absence of emission in …

Decentralized Cooperative Localization For Multi-Robot Systems In Challenging Environments, Eduardo Gutierrez

Graduate Theses, Dissertations, and Problem Reports (ETD)

Multi-robot systems provide more adaptability and robustness than conventional single-robot systems. This is because they have the ability to achieve partial completion of a task in the presence of failures due to the intrinsic inclusion of non-single-point failure. In multi-robot systems, cooperative localization refers to the use of relative measurements to improve the group’s overall localization performance. While centralized architectures in the system may result in unfeasible cases due to the high cost of computation and communication, decentralized methods distribute the computation among the robots in the group, enhancing the performance and making the system more efficient. Achieving a reliable …

Static Liquefaction In Tailing Dams, Jose Raul Zela Concha

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Fundao tailing dam in Brazil failed on November 5, 2015 causing loss in life, property and severe damage to the environment. The waste flow traveled at 11m/s and approximately 32 million m³ tailings was released into the downstream area. Investigations by regulators concluded that a series of poor designs and construction of the tailing were the causes of the failure. Further investigations also showed that surface failure occurred in the mid height of the slope with a safety factor of 0.52. Both investigations concluded that static liquefaction induced the failure of tailings dam. However, geology variation in the …

Synthesis, Characterization, And Activation Of Pyridine Dipyrrolide Supported Vanadium-Nitrogen Multiple Bonds, Jordan Cruz Martinez

Graduate Theses, Dissertations, and Problem Reports (ETD)

The chemistry of coordination complexes of vanadium supported by pyridine di-pyrrolide pincer ligands was probed via the synthesis and investigation of a variety of compounds from the trivalent starting material, (^MesPDP^Ph)VCl(thf)₂. Under reducing conditions and subsequent addition of terpyridine, a redox transfer series (1-, 0, 1+) stemming from the neutral product (^MesPDP^Ph)V(terpy) was isolated and characterized by X-ray crystallography. The precise bond lengths, in conjunction with bulk magnetic susceptibility, allowed for a detailed study of the redox non-innocence of polypyridyl ligands in these systems.

Metathesis of the halide starting material …

Probabilistic Space Weather Modeling And Forecasting For The Challenge Of Orbital Drag In Space Traffic Management, Richard J. Licata Iii

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the modern space age, private companies are crowding the already-congested low Earth orbit (LEO) regime with small satellite mega constellations. With over 25,000 objects larger than 10 cm already in LEO, this rapid expansion is forcing us towards the enterprise on Space Traffic Management (STM). STM is an operational effort that focuses on conjunction assessment and collision avoidance between objects. While the equations of motion for objects in orbit are well-known, there are many uncertain parameters that result in the uncertainty of an object's future position. The force that the atmosphere exerts on satellite - known as drag - …

“Where Did Your Christ Come From”? Exploring The Significance And Prevalence Of The White Jesus Phenomenon Among Black Baptist Women And Men, Stephanie Marshelle House-Niamke

Graduate Theses, Dissertations, and Problem Reports (ETD)

Berger's theory of religion and world construction fails to consider the critical issue of power and who is allowed to construct their own reality and thus, does not adequately capture the experience of Black Christians and the Black religious experience. I use White Jesus as a case study to analyze this process. Though the White Jesus phenomenon has been more readily explored in theological and historical fields, very little sociological research discusses this phenomenon. I argue that a Europeanized Jesus has had harmful sociocultural effects on Black Christians and Black people, in the form of cultural trauma. Yet, the White …

First Responders’ Assumptions: An Exploration Of Emergency Medical Technicians’ Secondary Traumatic Stress And Perceptions Of Substance Users, Glenn Noble

Graduate Theses, Dissertations, and Problem Reports (ETD)

Emergency medical technicians (EMT) and firefighters respond to critical incidents and provide emergent care. As the opioid crisis continues and drug overdose rates increase, first responders administer first aid to substance users, including Naloxone, more frequently. This study examined the influence of repeated exposure to drug-related critical incidents and provision of care to substance users on EMTs' and firefighters' secondary traumatic stress (STS) level, world assumptions, and substance use stigma. First responders' world assumptions, STS, burnout, and exposure to drug-related overdoses were analyzed for their power in predicting substance use stigma. Results suggest that occupational burnout, rather than STS, is …

Structure-Dependent Characterizations Of Multistationarity In Mass-Action Reaction Networks, Galyna Voitiuk

Graduate Theses, Dissertations, and Problem Reports (ETD)

This project explores a topic in Chemical Reaction Network Theory. We analyze networks with one dimensional stoichiometric subspace using mass-action kinetics. For these types of networks, we study how the capacity for multiple positive equilibria and multiple positive nondegenerate equilibria can be determined using Euclidian embedded graphs. Our work adds to the catalog of the class of reaction networks with one-dimensional stoichiometric subspace answering in the affirmative a conjecture posed by Joshi and Shiu: Conjecture 0.1 (Question 6.1 [26]). A reaction network with one-dimensional stoichiometric subspace and more than one source complex has the capacity for multistationarity if and only …

Mechanistic Insight Into Chronic Stress-Induced Cerebrovascular Dysfunction, Emily Nicole Burrage

Graduate Theses, Dissertations, and Problem Reports (ETD)

Despite decades of research psychological stress remains a prevalent problem in society, often diminishing quality of life and increasing the risk of developing dementia. The brain plays a central role in the response to stress and as it is unable to store energy substrates, the brain relies heavily on dynamically regulated blood flow. Therefore, it is important that there is a tight coupling between neural activity and cerebral blood flow to meet metabolic demands and maintain critical brain function. It has been established that chronic psychological stress has detrimental effects on cerebrovascular function, potentially through increased superoxide anion production through …

“Here Is The Place, My Lord”: The Scenic Design Process For King Lear, Abigail E. Wagner

Graduate Theses, Dissertations, and Problem Reports (ETD)

Undertaking the role of Scenic Designer of West Virginia University School of Theatre & Dance’s 2021 filmed production of King Lear by William Shakespeare was a formidable challenge. A detailed description of the entire scenic design process includes script analysis, research, design meetings, scenic art techniques, and the filming process. It illustrates the journey of what began as a series of renderings and models, transforming into the finalized version of the scenic design.

Examining Development And Function Of Pretectal Visual Neural Circuits In Gs Homeobox 1 Mutant Zebrafish, Alexandra Rose Schmidt

Graduate Theses, Dissertations, and Problem Reports (ETD)

Brain development requires a coordinated genetic code to regulate initial cell identity determination, migration, and connectivity, to establish function of neural circuits. Independent neural circuits underlie our ability to produce both complex and innate behavioral responses to sensory stimuli that are often conserved across vertebrate organisms. Sensory processing disruptions are associated with several neurodevelopmental disorders (NDDs). Therefore, gene mutations altering neurodevelopment can lead to changes influencing structure and function of individual neural circuits, causing behavioral deviations in sensory responsiveness. Crucial gene networks that define functional properties of sensory domains are often explored using non-mammalian vertebrate models, such as the zebrafish. …

Review Of Innovative Rehabilitation Techniques For Reinforced Concrete Buildings, Demetrius Karoubas

Graduate Theses, Dissertations, and Problem Reports (ETD)

Building rehabilitation encompasses the act of repairing damaged structural elements, as well as the upgrading of older buildings to bring them up to modern standards. In recent years, due to the extreme economic and environmental cost of new construction, building rehabilitation is gaining ground as the most viable solution to the problem posed by damaged or substandard buildings. With the constant development of new materials with favorable properties and the improvement of our understanding of earthquakes, new rehabilitation techniques are being developed, improving on the efficiency and effectiveness of older ones. Reinforced Concrete (RC) buildings are a type of building …

It’S A Bleed: Pediatric Hemophilia And Length Of Stay, Rural Vs Urban Hospitals, Daniel G. Liedl

Graduate Theses, Dissertations, and Problem Reports (ETD)

Hemophilia is a rare genetic disorder that requires specialty care and treatment. Pediatric patients with hemophilia have unique medical issues that may lead to permanent disability or death if not properly diagnosed and treated in a timely manner. Due to lack of resources and proper training of staff, rural hospitals are not equipped to properly treat pediatric hemophilia patients. Utilizing the Healthcare Cost and Utilization Project (HCUP) Kids´ Inpatient Database (KID) of the Agency for Healthcare Research and Quality. I have found, across all hospital types, pediatric hemophilia patients have longer lengths of stay, 2.7 days for rural hospitals, 4.6 …

Enhanced Sampling Techniques Reveal Key Information About Membrane Active Peptides, Nicolas Charles Frazee

Graduate Theses, Dissertations, and Problem Reports (ETD)

Membrane active peptides (MAPs) show promise in terms of future drug development. Whether it be adapting macrocycles for use in targeting protein-protein interactions or adopting cell-penetrating peptides (CPPs) to cause lysis in target cells, the field is burgeoning with possibilities for designer drugs. The following work encompasses the exploration of three such peptides. The pH-Low Insertion Peptide (pHLIP) is a membrane-active peptide that spontaneously folds into a transmembrane $\alpha$-helix upon acidification. This activity enables pHLIP to potentially act as a vector for drugs related to diseases characterized by acidosis such as cancer or heart ischemia. First, we explored the conformational …

An Investigation Into The Mechanism Of Proteasome Dysfunction In Neurodegenerative Disease And The Biological Impact Of Proteasome Hyperactivation In C. Elegans, Raymond T. Anderson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Aging is an inevitable process that occurs as humans grow older. It is characterized by the chronological accumulation of cellular damage over time leading to functional decline as an organism grows older. Several processes are thought to contribute to the aging phenomenon, but one of the most prolific of these is the disruption of protein homeostasis (proteostasis). The collapse of proteostasis can lead to accelerated aging and the development of age-related diseases including devastating neurodegenerative diseases (NDs) like Alzheimer and Parkinson disease. Virtually all NDs are characterized by the buildup of proteins in and around neurons resulting in neuronal death …

Prevalence Of Cortical Bone Fenestration And Sinus Membrane Thickening In Association With Endodontic Infection. A Review Of Cbct Scans., David Desta

Graduate Theses, Dissertations, and Problem Reports (ETD)

Prevalence of Cortical Bone Fenestration and Sinus Membrane Thickening in Association with Endodontic Infection. A review of CBCT scans.

Introduction

Although a systemic disease due to the spread of endodontic infection is very rare or non-existing, the dissemination of endodontic infection into intimately associated anatomical structures such as alveolar bone and maxillary sinus are known (1-4). In this study we examined and reported the prevalence of maxillary sinus involvement and cortical bone fenestration during an endodontic infection. The study also evaluated and presented association between factors such as (type of teeth, systemic diseases, patient’s age, and gender) and radiographic presentation …

Evaluating Remote Economic Benefits Of Watershed-Scale Acid Mine Drainage Restoration, Rachel E. Pell

Graduate Theses, Dissertations, and Problem Reports (ETD)

In 2011, the West Virginia Abandoned Mine Lands and Reclamation Program (WVAML) implemented a watershed-scale restoration project in Three Fork Creek, a 103 square-mile watershed in rural West Virginia impaired by acid mine drainage (AMD). This was accomplished through the installation of four in-stream lime dosers in 2011. Due to the great capital investment in the restoration of Three Fork Creek and an interest in applying this watershed-scale approach to other watersheds throughout West Virginia, it is of great interest to demonstrate the successes of this remediation. It has already been demonstrated that the watershed has visibly improved and is …

Reproductive Rates, Kitten Survival, And Den Site Selection Of Bobcats (Lynx Rufus) In The Black Hills, South Dakota, Erin E. Morrison

Graduate Theses, Dissertations, and Problem Reports (ETD)

The bobcat (Lynx rufus) is an important furbearer in South Dakota. However, management of bobcats can be difficult because of their elusive nature and lack of demographic information. In particular, managers lack information on abundance, survival, and reproductive rates necessary to ensure sustainable harvests and stable populations through time. Additionally, cause-specific mortality can provide insight into the factors influencing bobcat kitten survival rates, as well as reveal actions managers could take to improve survival. Bobcat resource selection can vary depending on spatial scale and it is important to understand how denning may result in different selection patterns at …

Implementation Of Stress Management And Resiliency Training To Address Nursing Burnout In A Neuroscience Critical Care Unit, Jessica May Marie Hughes

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the United States, over one-third of nurses experience symptoms of burnout (Reith, 2018). If left unchecked, poor stress management and resiliency skills can contribute to nursing burnout, leading to costly employee turnover. Stress management and resiliency training (SMART) provides the tools necessary to develop resiliency, improve stress management and decrease burnout (Resilient Option, 2020). Nursing staff under the age of 36, who work in a Neurosciences Critical Care Unit (NCCU) demonstrate lower resiliency scores and a higher risk of burnout. This project aimed to evaluate: (a) the effects of a SMART program on the wellbeing of nursing staff in …

Implementation Of An Amiodarone Infusion Nurse Practice Guideline To Reduce The Incidence Of Phlebitis: A Quality Improvement Project, Kristen N. Cottrill

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Patients have an increased risk of developing phlebitis when amiodarone is delivered through a peripheral intravenous catheter. In a 32-bed cardiac surgery step-down unit, patients experienced phlebitis at a rate of 28.57% despite following manufacturer recommendations. Individual interventions targeted at amiodarone-related phlebitis have presented mixed results, however, when an amiodarone infusion practice guideline was established, the rate and severity of phlebitis consistently decreased across studies. Purpose: This project aimed to implement an evidence-based amiodarone infusion guideline to reduce phlebitis development or severity in cardiac-surgery step-down patients without a central venous catheter who received a peripheral intravenous infusion of amiodarone. …

Evaluating The Feasibility Of A Collaborative Care Clinical Pathway For The Treatment Of Adolescent Depression And Anxiety In Rural Pediatric Primary Care, Kayla R. Watson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Evaluating the Feasibility of a Collaborative Care Clinical Pathway for the Treatment of Adolescent Depression and Anxiety in Rural Pediatric Primary Care

Kayla Watson

Background: Due to a national shortage of Child and Adolescent Psychiatrists (CAP), Primary Care Providers (PCP) are often required to manage patients with mental health disorders despite a lack of focused training and lower self-efficacy or confidence in the management of these disorders. Referral to CAPs for management following the diagnosis of adolescent depression and anxiety is a common practice. The integration of mental health services within the primary care setting can overcome many of these …

Size Effect And Anisotropy On The Strength Of Shale Under Compressive Stress Conditions, Yun Zhao

Graduate Theses, Dissertations, and Problem Reports (ETD)

The underground coal mines in the Appalachian region report the highest rate of roof falls in the United States. The immediate roof of these mines is mostly composed of shale. The in-situ strength of shale is necessary for designing roof support to prevent roof falls. Estimating the in-situ strength of shale requires the knowledge of both size effect and anisotropy. This research used literature review, theoretical analysis, numerical modeling, and laboratory experiment to systematically investigate the size effect and anisotropy of shale strength under compressive strength conditions.

Literature review involved a comprehensive summary of previous research on the size effect …

Macroarchaeology, Epistomology, And The Quality Of The Archaeological Record, James R. Allison

Faculty Publications

Perrault (2019) combines a critique of current archaeological practice with a call to re-center research on questions of culture history as well as “macroarchaeology”, or the search for large-scale patterns of human behavior and cultural development. His arguments for what archaeologists should do (and stop doing) are driven by the way the quality of the archaeological record underdetermines the answers to questions that archaeologists often seek to answer. There is much to like in Perrault’s arguments, but there also are some problematic aspects. I agree that something like Perrault’s macroarchaeology should receive greater focus within the discipline, and that archaeologists …

Rethinking Countercyclical Financial Regulation, Jeremy C. Kress, Matthew C. Turk

Georgia Law Review

The 2008 financial crisis exposed a longstanding problem in financial regulation: traditional regulatory strategies tend to be procyclical. That is, regulatory tools—most notably, bank capital requirements—incentivize excessive credit growth during economic expansions and insufficient lending during contractions. The procyclicality of U.S. financial regulation was a key driver of the housing bubble in the mid-2000s and the massive credit crunch that followed. To combat this phenomenon, Congress and the federal banking agencies attempted to mitigate procyclical boom-and-bust cycles by implementing regulatory approaches that were explicitly countercyclical. The Dodd-Frank Act and related post-crisis reforms included several countercyclical features that were designed to …

The Unidentified Wrongdoer, Ronen Perry

Georgia Law Review

This Article addresses the untheorized and under-researched problem of strong unidentifiability in tort law, namely the victim’s occasional inability to identify the direct wrongdoer, or even an ascertainable group to which the wrongdoer belongs, and bring an action against him or her. This Article offers a systematic analysis and a general theoretical framework for the appraisal of possible solutions to strong unidentifiability problems, which undermine liability and frustrate its goals.

Part I presents the main legal models developed and used to overcome these problems in different contexts and various legal systems: adherence to direct liability with creative procedural identification tools, …

Table Of Contents

Georgia Law Review

No abstract provided.

Uzuegbunam V. Preczewski, Nominal Damages, And The Roberts Stratagem, Michael Wells

Georgia Law Review

In Uzuegbunam v. Preczewski the Supreme Court held for the first time that federal-court jurisdiction exists over a § 1983 case that presents only a claim for nominal damages. As a result, such claims remain subject to adjudication even when the plaintiff’s request for prospective relief, targeting an allegedly unlawful practice, has been mooted by the government’s discontinuance of the thus-challenged behavior. In dissent, Chief Justice Roberts maintained that the majority’s ruling clashed with Article III’s “personal stake” requirement and also unwisely permitted plaintiffs to sidestep controlling jurisdictional rules by adding a meaningless claim for nominal damages to a complaint …