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Decreased Trends Of Using Dental Amalgam Filling For Decayed Teeth In Taiwan From 1997 To 2013, Li-Chiu Yang, Fu-Hsuan Liu, Ni-Yu Su, Yu-Hsun Wang, Po-Yu Yang, Yu-Chao Chang Jan 2022

Decreased Trends Of Using Dental Amalgam Filling For Decayed Teeth In Taiwan From 1997 To 2013, Li-Chiu Yang, Fu-Hsuan Liu, Ni-Yu Su, Yu-Hsun Wang, Po-Yu Yang, Yu-Chao Chang

Journal of Dental Sciences

Abstract Background/purpose Mercury within dental amalgam has been criticized for the potential toxicity and environmental hazard. Phasing down the use of dental amalgam is the transition for amalgam free dentistry. However, little is known about dental amalgam filling (AMF) in Taiwan. In this study, time trends of AMF were measured by using National Health Insurance Research Database (NHIRD). Materials and methods A retrospective study was conducted to analyze the AMF data in registered database compiled by Taiwanese NHIRD from 1997 to 2013. The AMF data were further analyzed according to sex, age, and geographic location, respectively. Time trends of dental …

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Integrating Virtual And Light Microscopy For Oral Histology And Oral Pathology Lessons: Indian Scenario, Rahul Anand, Gargi Sarode, Sachin Sarode Jan 2022

Integrating Virtual And Light Microscopy For Oral Histology And Oral Pathology Lessons: Indian Scenario, Rahul Anand, Gargi Sarode, Sachin Sarode

Journal of Dental Sciences

No abstract provided.

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High Frequencies Of Vitamin B12 And Folic Acid Deficiencies And Hyperhomocysteinemia In Taiwanese Male Patients With Oral Submucous Fibrosis, Yu-Hsueh Wu, Yi-Pang Lee, Julia Yu-Fong Chang, Yi-Ping Wang, Chun-Pin Chiang, Andy Sun Jan 2022

High Frequencies Of Vitamin B12 And Folic Acid Deficiencies And Hyperhomocysteinemia In Taiwanese Male Patients With Oral Submucous Fibrosis, Yu-Hsueh Wu, Yi-Pang Lee, Julia Yu-Fong Chang, Yi-Ping Wang, Chun-Pin Chiang, Andy Sun

Journal of Dental Sciences

Abstract Background /purpose: Oral submucous fibrosis (OSF) is a betel quid chewing-caused oral mucosal disease with progressive collagen deposition. This study evaluated whether Taiwanese male OSF patients had high frequencies of vitamin B12 and folic acid deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity. Materials and methods The blood hemoglobin (Hb), serum iron, vitamin B12, folic acid, homocysteine, and GPCA concentrations in 62 male OSF patients were measured and compared with the corresponding data in 124 age-matched male healthy control subjects. Results We found that 5 (8.1%), 12 (19.4%), 32 (51.6%), 31 (50.0%), 22 (35.5%), and 6 (9.7%) …

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Radiographic Characteristics Of Odontomas In Patients In The National Taiwan University Children's Hospital, Chun-Pin Chiang, Feng-Chou Cheng, Julia Chang, Mu-Hsiung Chen, Yi-Chen Chen, Hsiao-Yi Chen, Yin-Lin Wang Jan 2022

Radiographic Characteristics Of Odontomas In Patients In The National Taiwan University Children's Hospital, Chun-Pin Chiang, Feng-Chou Cheng, Julia Chang, Mu-Hsiung Chen, Yi-Chen Chen, Hsiao-Yi Chen, Yin-Lin Wang

Journal of Dental Sciences

Abstract Background/purpose Odontoma is the most common odontogenic tumor. A literature review revealed limited data for odontomas in Taiwan. This study evaluated the radiographic characteristics of odontomas in 1280 patients in the National Taiwan University Children's Hospital (NTUCH). Materials and methods This retrospective study analyzed the odontomas based on examination of mainly panoramic radiographs and related radiographs of 1280 patients in the NTUCH. Chi-square test was used for trend analysis. Results Among 1280 patients (710 boys and 570 girls), a total of 16 patients with odontomas (10 boys and 6 girls) were identified. There were 14 compound and 2 complex …

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Overview Of Dental Education System And Gender Distribution Of Undergraduate Dental Students In Taiwan, Chun-Pin Chiang, Feng-Chou Cheng, Yin-Lin Wang, Ling-Hsia Wang, Julia Chang, Shiang-Yao Liu Jan 2022

Overview Of Dental Education System And Gender Distribution Of Undergraduate Dental Students In Taiwan, Chun-Pin Chiang, Feng-Chou Cheng, Yin-Lin Wang, Ling-Hsia Wang, Julia Chang, Shiang-Yao Liu

Journal of Dental Sciences

Abstract Background/purpose The gender distribution of dentists in Taiwan has been dominated by male dentists for a long time. This study analyzed preliminarily the appearance of the current dental education system and the gender distribution of undergraduate dental students. Materials and methods This study used documentary analysis and secondary data analysis to survey mainly the current dental education system and the gender distribution of undergraduate dental students in Taiwan. Results There were a total of 2474 dental students and 394 dental graduates in Taiwan in 2021. The numbers of male students (1435, 58.00%) and male graduates (207, 52.54%) were higher …

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Overview Of Dental Radiology Education For Medical Radiology Students In Taiwan, Chun-Pin Chiang, Feng-Chou Cheng, Mu-Hsiung Chen, Chih-Chung Hu, Li-Hua Tang, Yan-De Liou, Po-Fang Tsai Jan 2022

Overview Of Dental Radiology Education For Medical Radiology Students In Taiwan, Chun-Pin Chiang, Feng-Chou Cheng, Mu-Hsiung Chen, Chih-Chung Hu, Li-Hua Tang, Yan-De Liou, Po-Fang Tsai

Journal of Dental Sciences

Abstract Background/purpose In Taiwan, the formal education for cultivating medical radiation technologists began in 1965. However, there are very few dental radiology curricula in Taiwan's medical radiology schools. We investigated mainly the appearance of dental radiology education for medical radiology students in Taiwan. Materials and methods We used documentary analysis, a survey of dental radiology education, and secondary data analysis in this study to find the appearance of Taiwan's dental radiology education for medical radiology students. Results There were currently ten medical radiology schools. Among them, five offered independent curricula in their subject schedules and another five had dental radiology …

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Overexpression Of Transient Receptor Potential Melastatin 6 During Human Oral Squamous Cell Carcinogenesis, Yen-Yun Wang, Wen-Chen Wang, Chiang-Wei Su, Ching-Wei Hsu, Shyng-Shiou Yuan, Yuk-Kwan Chen Jan 2022

Overexpression Of Transient Receptor Potential Melastatin 6 During Human Oral Squamous Cell Carcinogenesis, Yen-Yun Wang, Wen-Chen Wang, Chiang-Wei Su, Ching-Wei Hsu, Shyng-Shiou Yuan, Yuk-Kwan Chen

Journal of Dental Sciences

Abstract Background/purpose Transient receptor potential melastatin (TRPM) channel is involved in cell proliferation and cell survival. Eight members (TRPM1–8) are within the TRPM subfamily. The current study is aimed to investigate TRPM6 expression in human oral carcinogenesis. Materials and methods Sixty-six oral squamous cell carcinomas (OSCCs), 47 oral potentially malignant disorders (OPMD) with moderate-severe epithelial dysplasia (ED), 28 OPMD with mild ED, and 33 normal oral mucosa (NOM) samples were subjected to immunohistochemical staining. Two human oral cancer cell lines (OCCLs), an oral premalignant cell line (DOK), and a normal oral keratinocyte culture (HOK) were used for Western blot analysis. …

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Higher Frequencies Of Anemia, Hematinic Deficiencies, And Gastric Parietal Cell Antibody Positivity In Vitamin B12-Deficient Taiwanese Male Oral Submucous Fibrosis Patients, Chun-Pin Chiang, Yu-Hsueh Wu, Yi-Pang Lee, Julia Chang, Yi-Ping Wang, Andy Sun Jan 2022

Higher Frequencies Of Anemia, Hematinic Deficiencies, And Gastric Parietal Cell Antibody Positivity In Vitamin B12-Deficient Taiwanese Male Oral Submucous Fibrosis Patients, Chun-Pin Chiang, Yu-Hsueh Wu, Yi-Pang Lee, Julia Chang, Yi-Ping Wang, Andy Sun

Journal of Dental Sciences

Abstract Background/purpose Oral submucous fibrosis (OSF) is a progressive fibrotic oral mucosal disease associated with betel quid chewing. This study evaluated whether Taiwanese male OSF patients with vitamin B12 deficiency (the serum vitamin B12 level ≤ 450 pg/mL, B12-deficient OSF patients) had high frequencies of blood hemoglobin (Hb) and serum iron and folic acid deficiencies, and serum gastric parietal cell antibody (GPCA) positivity. Materials and methods The blood Hb and serum iron, vitamin B12, folic acid, and GPCA concentrations in 66 Taiwanese male B12-deficient OSF patients were measured and compared with the corresponding data in 132 age-matched healthy male control …

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Physiological Reaction Of Anxious Patients Taking Sedative Medications Before And After Periodontal Surgery, I-Ping Lin, Po-Chun Chang Jan 2022

Physiological Reaction Of Anxious Patients Taking Sedative Medications Before And After Periodontal Surgery, I-Ping Lin, Po-Chun Chang

Journal of Dental Sciences

Background/purpose Clinicians use sedatives for anxiety patients at times in daily practice, but the direct influence of the medication on the wound healing of periodontal tissues is unknown. The aim of this study was to analyze the influence of the short-term administration of diazepam to patients with dental anxiety undergoing free gingival graft (FGG) procedures. Materials and methods A total of 51 FGG procedures in 39 patients were included. Twenty-six anxious patients medicated with 5 mg of diazepam from the night before surgery to 7 days after surgery served as the medication group, and the rest served as the control …

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Treatment Of Class Ii Malocclusion With Invisalign®: A Pilot Study Using Digital Model-Integrated Maxillofacial Cone Beam Computed Tomography, Jenny Zwei-Chieng Chang, Shih-Yin Lin, Min-Chih Hung, Li-Hsin Lu, Jui-Sheng Sun, Shih-Jaw Tsai Jan 2022

Treatment Of Class Ii Malocclusion With Invisalign®: A Pilot Study Using Digital Model-Integrated Maxillofacial Cone Beam Computed Tomography, Jenny Zwei-Chieng Chang, Shih-Yin Lin, Min-Chih Hung, Li-Hsin Lu, Jui-Sheng Sun, Shih-Jaw Tsai

Journal of Dental Sciences

Abstract Background/purpose The treatment effects of Invisalign® are still obscure due to methodological limitations of previous studies. We introduced a method to comprehensively evaluate the dental and skeletal changes of Class II malocclusion treated non-extraction with Invisalign® and compare with the virtual simulation of ClinCheck® using digital models integrated into maxillofacial cone-beam computed tomography (CBCT). Materials and methods The pretreatment (T1) and posttreatment (T2) scanned digital images of actual dentitions were integrated into maxillofacial CBCT images. To evaluate three-dimensional movement of maxillary teeth and change of mandible position, T1 and T2 digital model-integrated maxillofacial CBCT images were superimposed using voxel-based …

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Critical Thinking Education For Dental Schools In Asia: Perceptions Of Educators, Naoko Seki, Kittichai Sireerat, Richard Foxton, Shin-Ru Liao, Ikuko Morio Jan 2022

Critical Thinking Education For Dental Schools In Asia: Perceptions Of Educators, Naoko Seki, Kittichai Sireerat, Richard Foxton, Shin-Ru Liao, Ikuko Morio

Journal of Dental Sciences

Abstract Teaching competence in critical thinking is an important element of undergraduate dental curricula. The pedagogy for critical thinking education in Asia requires further discussion and neither the current situation nor the possible challenges are widely known from the perspectives of dental educators. Therefore, seven educators from four countries gathered online in the summer of 2021 to share the current situation and possible challenges. All the participants considered “critical thinking” was “important” (43%) or “very important” (57%), however, 86% mentioned that they faced challenges in delivering education in critical thinking. The challenges to delivering critical thinking education were insufficient time …

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Oral Squamous Cell Carcinoma Diagnosis In Digitized Histological Images Using Convolutional Neural Network, Satoru Toyosawa, Kaori Oya, Kazuma Kokomoto, Kazunori Nozaki Jan 2022

Oral Squamous Cell Carcinoma Diagnosis In Digitized Histological Images Using Convolutional Neural Network, Satoru Toyosawa, Kaori Oya, Kazuma Kokomoto, Kazunori Nozaki

Journal of Dental Sciences

Abstract Background/purpose Diagnostic methods of oral squamous cell carcinoma (SCC) using artificial intelligence (AI) and digital-histopathologic images have been developed. However, previous AI training methods have focused on the cellular atypia given by the training of high-magnification images, and little attention has been paid to structural atypia provided by low-power wide fields. Since oral SCC has histopathologic types with bland cytology, both cellular atypia and structural atypia must be considered as histopathologic features. This study aimed to investigate AI ability to judge oral SCC in a novel training method considering cellular and structural atypia and their suitability. Materials and methods …

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Perspectives On Salivary Cytokines As Noninvasive Biomarkers For Monitoring Disease Activity And Therapeutic Response Of Oral Lichen Planus, Wei Liu, Junjun Chen, Guanhuan Du Jan 2022

Perspectives On Salivary Cytokines As Noninvasive Biomarkers For Monitoring Disease Activity And Therapeutic Response Of Oral Lichen Planus, Wei Liu, Junjun Chen, Guanhuan Du

Journal of Dental Sciences

No abstract provided.

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The Investigation Of Composition And Thermal Behavior Of Two Types Of Backfilling Gutta-Percha, Sung-Chih Hsieh Jan 2022

The Investigation Of Composition And Thermal Behavior Of Two Types Of Backfilling Gutta-Percha, Sung-Chih Hsieh

Journal of Dental Sciences

Abstract Background/purpose In the warm gutta-percha technique, soft-type and regular-type gutta-percha are using for backfilling thermoplasticized injection system. However, there are limited reports about the properties of these backfilling gutta-percha. This study aimed to analyze and compare the composition, thermal behavior and compact force of two types of backfilling gutta-percha. Materials and methods Soft-type and regular-type backfilling gutta-percha (B&L BioTech, Fairfax, VA, USA) were investigated. The inorganic and organic fractions of these gutta-perchas were separated by quantitative chemical analysis (n = 6). Their composition was analyzed using energy dispersive spectroscopy. Thermal behavior in response to temperature variations was analyzed using …

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Association Of Salivary Mirnas With Onset And Progression Of Oral Potentially Malignant Disorders: Searching For Noninvasive Biomarkers, Xuemin Shen, Wei Liu, Huan Shi, Zengtong Zhou, Chenping Zhang Jan 2022

Association Of Salivary Mirnas With Onset And Progression Of Oral Potentially Malignant Disorders: Searching For Noninvasive Biomarkers, Xuemin Shen, Wei Liu, Huan Shi, Zengtong Zhou, Chenping Zhang

Journal of Dental Sciences

Abstract Background/purpose There is an urgent need for noninvasive biomarkers to diagnose oral potentially malignant disorders (OPMD). A wide range of over 20 miRNAs in saliva of OPMD patients have been investigated in different studies. Yet, which of the ones provide a better power of discrimination for the diagnosis of OPMD onset and progression are uncertain. Materials and methods A total of 17 eligible studies including 426 cases of OPMD and 486 control subjects (352 normal mucosa and 134 oral squamous cell carcinoma) were summarized. Results The bubble chart analysis showed that the most power salivary miRNA associated with OPMD …

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Performance Of High-Translucent Zirconia Cad/Cam Fixed Dental Prostheses Using A Digital Workflow: A Clinical Study Up To 6 Years, Ilser Turkyilmaz Jan 2022

Performance Of High-Translucent Zirconia Cad/Cam Fixed Dental Prostheses Using A Digital Workflow: A Clinical Study Up To 6 Years, Ilser Turkyilmaz

Journal of Dental Sciences

Abstract Background/purpose Zirconia has recently become a popular material for fixed restorations. The purpose of this study was to use a digital workflow to fabricate monolithic zirconia fixed dental prostheses (FDPs) and assess the connection between variable connector sizes compared to their clinical performance. Materials and methods Clinicians evaluated monolithic zirconia FDPs in 58 patients. After definitive impressions were made, stone casts were obtained. The stone casts were scanned to a standard triangle language (STL) file. A digital wax up was fabricated, and corresponding provisional restorations were milled. Final FDPs were fabricated from a high-translucent zirconia material. During digital fabrication, …

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Effects Of Ethylenediaminetetraacetic Acid On Stem Cells From The Apical Papilla: In Vitro Study, Thanaphum Osathanon, Suphalak Phothichailert, Benya Sangwisutsai, Dhitinant Rattanakosol, Nutcha Teerapongpaibul, Sirawut Hiran-Us, Nunthawan Nowwarote Jan 2022

Effects Of Ethylenediaminetetraacetic Acid On Stem Cells From The Apical Papilla: In Vitro Study, Thanaphum Osathanon, Suphalak Phothichailert, Benya Sangwisutsai, Dhitinant Rattanakosol, Nutcha Teerapongpaibul, Sirawut Hiran-Us, Nunthawan Nowwarote

Journal of Dental Sciences

Abstract Background/purpose Ethylenediaminetetraacetic acid (EDTA) is used as an irrigant in regenerative endodontic treatment. The present study aimed to investigate the effects of EDTA on stem cells from apical papilla (SCAPs) in vitro . Materials and methods Human SCAPs were isolated and characterised. The cells were treated with media supplemented with EDTA at concentrations ranging from 1.25% to 17%. Cell proliferation and apoptosis were examined using MTT assay and annexin V/propidium iodide staining. Cell migration was determined by a scratch assay. Gene expression was evaluated using a real-time polymerase chain reaction. Mineral deposition, a hallmark of osteogenesis in vitro , …

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Management Of Maxillofacial Gunshot Injury With Severe Tissue Avulsion, Yuan Kai Ke, Chih-Yuan Fang, Yu Cheng Cheng, Po Chih Hsu Jan 2022

Management Of Maxillofacial Gunshot Injury With Severe Tissue Avulsion, Yuan Kai Ke, Chih-Yuan Fang, Yu Cheng Cheng, Po Chih Hsu

Journal of Dental Sciences

No abstract provided.

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Surgical Treatment And Prognosis Of Posteriorly Invading Oral Cancer: Potential Clinical Significance Of Pterygomandibular Raphe, Mitsunobu Otsuru, Souichi Yanamoto, Tomofumi Naruse, Keisuke Omori, Kota Morishita, Misa Sumi, Masahiro Umeda Jan 2022

Surgical Treatment And Prognosis Of Posteriorly Invading Oral Cancer: Potential Clinical Significance Of Pterygomandibular Raphe, Mitsunobu Otsuru, Souichi Yanamoto, Tomofumi Naruse, Keisuke Omori, Kota Morishita, Misa Sumi, Masahiro Umeda

Journal of Dental Sciences

Abstract Background/purpose The prognosis of oral squamous cell carcinoma (OSCC) with posterior invasion is poor. We examined whether the pterygomandibular raphe (PMR) is useful for the diagnosis of invasion and determination of surgical methods. Materials and methods Of 390 patients with OSCC treated surgically at our hospital between June 2009 and June 2020, 80 patients with posterior invasion were included in the study. Preoperative magnetic resonance imaging was used to classify the lesions into three types: non-contact with PMR (non-contact type), contact with PMR (contact type), and invasion beyond PMR (invasion type). We compared the local control, recurrence, and survival …

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The Combination Of The Mandibular Köle Procedure And Bilateral Sagittal Splitting In Orthognathic Surgery Has Positive Effect In Esthetics And Function For Short-Throat-Length Skeletal Class Iii Patient, Tracy Yi-Hsuan Lee, Chia-Nan Hung, Johnson Hsin-Chung Cheng, Chih-Yuan Fang Jan 2022

The Combination Of The Mandibular Köle Procedure And Bilateral Sagittal Splitting In Orthognathic Surgery Has Positive Effect In Esthetics And Function For Short-Throat-Length Skeletal Class Iii Patient, Tracy Yi-Hsuan Lee, Chia-Nan Hung, Johnson Hsin-Chung Cheng, Chih-Yuan Fang

Journal of Dental Sciences

No abstract provided.

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Selective Versus Stepwise Removal Of Deep Carious Lesions: A Meta-Analysis Of Randomized Controlled Trials, Yanhong Hao, Yao Yao, Aoxiang Luo Jan 2022

Selective Versus Stepwise Removal Of Deep Carious Lesions: A Meta-Analysis Of Randomized Controlled Trials, Yanhong Hao, Yao Yao, Aoxiang Luo

Journal of Dental Sciences

Abstract Background/purpose Stepwise removal (SWR) and selective removal (SCR) are proposed techniques to treat deep carious lesions, but it is currently uncertain which technique is better. This meta-analysis aimed to compare the therapeutic effects of SCR and SWR for deep carious lesions in both primary and permanent teeth. Materials and methods PubMed, Embase, Cochrane Library, Web of Science, CNKI, WanFang, and VIP databases were searched until June 9, 2021. Success was the primary outcome. Secondary outcomes included pulp exposure, tooth extraction, pulp necrosis, pulpitis, and endodontic treatment. The effect size of each outcome was tested for heterogeneity. The source of …

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Surface Modification Of Zirconia Ceramics Through Cold Plasma Treatment And The Graft Polymerization Of Biomolecules, Kuo-Ning Ho, Liang-Wei Chen, Tzong-Fu Kuo, Ko-Shao Chen, Sheng-Yang Lee, Sea-Fue Wang Jan 2022

Surface Modification Of Zirconia Ceramics Through Cold Plasma Treatment And The Graft Polymerization Of Biomolecules, Kuo-Ning Ho, Liang-Wei Chen, Tzong-Fu Kuo, Ko-Shao Chen, Sheng-Yang Lee, Sea-Fue Wang

Journal of Dental Sciences

Background/purpose Although zirconia ceramics were highly versatile as dental implants, their long-term presence in the human body may slow down healing and impede cell growth in the past. To enhance the cytocompatibility of zirconia ceramics, surface activation modification was used to immobilize biopolymers such that a biomimetic environment was created. Materials and methods Hexamethyldisilazane thin films were deposited onto the surface of inorganic zirconia through cold plasma treatment under various power and deposition time settings to form an organosilane interface layer. Next, oxygen plasma treatment was performed to activate the free radicals on the surface. Subsequently, ultraviolet light was employed …

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Fostering Globally Competent Dental Students Through Virtual Team-Working, Problem-Solving And Person-Centred Multi-Disciplinary Care Planning, Naoko Seki, Noriyuki Wakabayashi, Ikuko Morio, Yuna Kanamori, Richard Foxton, Janelle Moross, Yuriko Komagamine, Koji Mizutani, Keiichi Hosaka, Manabu Kanazawa, Takashi Hatayama, Wataru Komada, Ikuo Yonemitsu, Masako Akiyama, Paramaporn Kaewmanee, Nathawut Kaewsutha, Hiroshi Nitta Jan 2022

Fostering Globally Competent Dental Students Through Virtual Team-Working, Problem-Solving And Person-Centred Multi-Disciplinary Care Planning, Naoko Seki, Noriyuki Wakabayashi, Ikuko Morio, Yuna Kanamori, Richard Foxton, Janelle Moross, Yuriko Komagamine, Koji Mizutani, Keiichi Hosaka, Manabu Kanazawa, Takashi Hatayama, Wataru Komada, Ikuo Yonemitsu, Masako Akiyama, Paramaporn Kaewmanee, Nathawut Kaewsutha, Hiroshi Nitta

Journal of Dental Sciences

Abstract Background/purpose : Development and acquisition of communication, logical thinking, team-building, critical appraisal, critical thinking and person-centred multi-disciplinary care planning must be considered as skill sets and global core competencies for a dental professional. Therefore, an international online study course to foster undergraduate dental students’ skill sets in these areas was established and this study aimed to report the perceptions of participants. Materials and methods An international online course consisting of three levels pertaining to the school year was delivered to dental undergraduates of Japan and Thailand from September to December in 2021. An online questionnaire survey was conducted to …

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Inhibitory Effects Of Streptococcus Salivarius K12 On Formation Of Cariogenic Biofilm, Hyun-Jun Yoo, Hye-Ji Kim Jan 2022

Inhibitory Effects Of Streptococcus Salivarius K12 On Formation Of Cariogenic Biofilm, Hyun-Jun Yoo, Hye-Ji Kim

Journal of Dental Sciences

Abstract Bacground/purpose Streptococcus salivarius ( S. salivarius ) K12 is known to be a probiotic bacterium. The purpose of this study was to investigate anti-cariogenic effects of S. salivarius K12 on cariogenic biofilm. Materials and methods S. salivarius K12 was cultured in M17 broth. The antimicrobial activity of spent culture medium (SCM) against Streptococcus mutans was investigated. S. salivarius K12 was co-cultivated with S. mutans using a membrane insert. When the biofilm was formed using salivary bacteria and S. mutans , the K12 was inoculated every day. The biomass of biofilm was investigated by a confocal laser scanning microscope. Also, …

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Forskolin Enhanced The Osteogenic Differentiation Of Human Dental Pulp Stem Cells In Vitro And In Vivo, Shouliang Zhao, Changlong Jin, Han Xie Jan 2022

Forskolin Enhanced The Osteogenic Differentiation Of Human Dental Pulp Stem Cells In Vitro And In Vivo, Shouliang Zhao, Changlong Jin, Han Xie

Journal of Dental Sciences

Abstract Background/purpose Human dental pulp stem cells (hDPSCs) are multipotent adult stem cells that can differentiate into various lineages such as odontoblasts, osteoblasts, and chondrocytes. Regulation of hDPSCs differentiation with small-molecule compounds can be a useful tool for tissue engineering and regenerative therapy. Forskolin is an agonist of adenylate cyclase that promotes cyclic adenosine monophosphate production. However, the role of Forskolin in regulating the osteogenic differentiation of hDPSCs is still unknown. Materials and methods A cell counting kit-8 (CCK-8) assay was performed to screen out the safety concentrations of Forskolin. Following, quantitative polymerase chain reaction (qPCR) and alizarin red staining …

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Transforming Growth Factor-Β1 Promotes Early Odontoblastic Differentiation Of Dental Pulp Stem Cells Via Activating Akt, Erk1/2 And P38 Mapk Pathways, Qing Yu, Yu Bai, Xiaogang Cheng, Xin Liu, Qian Guo, Zhihua Wang, Yi Fu, Wenxi He Jan 2022

Transforming Growth Factor-Β1 Promotes Early Odontoblastic Differentiation Of Dental Pulp Stem Cells Via Activating Akt, Erk1/2 And P38 Mapk Pathways, Qing Yu, Yu Bai, Xiaogang Cheng, Xin Liu, Qian Guo, Zhihua Wang, Yi Fu, Wenxi He

Journal of Dental Sciences

Background/purpose TGF-β1 (Transforming growth factor-β1) plays an important role in the regeneration and repair of pulp-dentin complex. However, the biological function of TGF-β1 on odontoblastic differentiation remains unclear, mainly due to the processes of differentiation were controlled by complex signaling pathways. This study aimed to investigate the signaling pathways involved in regulating the early differentiation of dental pulp stem cells (DPSCs) by TGF-β1 and their functional role. Materials and methods DPSCs were treated with 1 ng/mL TGF-β1 and Western blotting was conducted to examine the activation of protein kinase B (AKT), small mothers against decapentaplegic 3 (Smad3), p38 mitogen-activated protein …

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Feasibility Of The Crude Extracts Of Amorphophallus Paeoniifolius And Colocasia Esculenta As Intracanal Medicaments In Endodontic Therapy In Comparison To The 940 Nm Diode Laser: An In Vitro Antimicrobial Study, Didar Sadiq Hama Gharib, Raid Salman Jan 2022

Feasibility Of The Crude Extracts Of Amorphophallus Paeoniifolius And Colocasia Esculenta As Intracanal Medicaments In Endodontic Therapy In Comparison To The 940 Nm Diode Laser: An In Vitro Antimicrobial Study, Didar Sadiq Hama Gharib, Raid Salman

Journal of Dental Sciences

Abstract Background/purpose The elimination and debridement of intracanal bacteria are credited with long-term effectiveness in endodontic therapy. This study aimed to compare the antimicrobial efficacies of Amorphophallus paeoniifolius (Suran), Colocasia esculenta (Aravi) crude extracts as intracanal medicaments with calcium hydroxide (CH), 2% chlorhexidine (CHX) gel, and 940 nm diode laser. Materials and methods Fifty-eight intact, single-root, extracted human mandibular premolar teeth were prepared. The samples were sterilized, transferred into microcentrifuge tubes, and inoculated with E. faecalis . The samples were placed in an incubator for three weeks to allow the biofilm to grow. Then the samples were randomly divided into …

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Role Of Immune-Related Lncrnas--Prkcq-As1 And Egot In The Regulation Of Il-1Β, Il-6 And Il-8 Expression In Human Gingival Fibroblasts With Tnf-Α Stimulation, Xiangying Ouyang, Quanquan Zhao, Jianru Liu, Wenyi Liu, Peiying Lv, Shengnan Zhang, Jinsheng Zhong Jan 2022

Role Of Immune-Related Lncrnas--Prkcq-As1 And Egot In The Regulation Of Il-1Β, Il-6 And Il-8 Expression In Human Gingival Fibroblasts With Tnf-Α Stimulation, Xiangying Ouyang, Quanquan Zhao, Jianru Liu, Wenyi Liu, Peiying Lv, Shengnan Zhang, Jinsheng Zhong

Journal of Dental Sciences

Abstract Background/purpose It was reported that lncRNAs have an effect on immune-related diseases, however, their roles in periodontitis remain to be investigated. The aim of this study was to look for immune-related lncRNAs in periodontitis, and to preliminarily explore their function in vitro . Materials and methods CIBERSORT was used to analyze abundance of immune cell in the periodontal tissue. Correlation between the expression profile of lncRNAs and abundance of immune cell was calculated and immune-related lncRNAs were identified. The expressions of immune-related lncRNAs identified were validated by RT-qPCR with 15 periodontitis and 15 healthy gingival tissues. The expressions of …

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The Left And Right Differences In Sella Turcica Bridging Between Sex Analyzed By Cone-Beam Computed Tomography, Yu-Chuan Tseng, Szu-Ting Chou, Chun-Ming Chen, Ping-Ho Chen, Ying-Chun Lin Jan 2022

The Left And Right Differences In Sella Turcica Bridging Between Sex Analyzed By Cone-Beam Computed Tomography, Yu-Chuan Tseng, Szu-Ting Chou, Chun-Ming Chen, Ping-Ho Chen, Ying-Chun Lin

Journal of Dental Sciences

No abstract provided.

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Condylar And Ramus Volume In Asymmetric And Symmetric Skeletal Class Iii Malocclusion: A Cone-Beam Computed Tomography Study, Yu-Chuan Tseng, Szu-Ting Chou, Pei-Lun Tsai, Shih-Chieh Chen, Shih-Hsuan Lin, Chun-Ming Chen Jan 2022

Condylar And Ramus Volume In Asymmetric And Symmetric Skeletal Class Iii Malocclusion: A Cone-Beam Computed Tomography Study, Yu-Chuan Tseng, Szu-Ting Chou, Pei-Lun Tsai, Shih-Chieh Chen, Shih-Hsuan Lin, Chun-Ming Chen

Journal of Dental Sciences

Abstract Background/purpose Among the craniofacial structures, the mandible is the only bony structure with movable joints. Each part (including condyle process, coronoid process, and ramus) of mandible would interaction with the muscles and proceed different osteogenesis progress. The objective of this study was to evaluate the mandibles with symmetric and asymmetric skeletal Class III jaw relations by quantifying differences in the condyle process, coronoid process and ramus on CBCT (Cone-beam computer tomography) images. Our hypothesis was that CBCT would reveal no voluminal differences between deviated and non-deviated mandibular segments in asymmetric skeletal Class III. Materials and methods CBCT imagines were …

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