Digital Commons Network^™

Irisin Relaxes Rat Thoracic Aorta Through Inhibiting Signaling Pathways Implicatingprotein Kinase C, Sadetti̇n Demi̇rel, Serdar Şahi̇ntürk, Naci̇ye İşbi̇l, Fadil Özyener

Turkish Journal of Medical Sciences

Background/aim: Irisin, a newly identified exercise-derived myokine, has been found involved in a peripheral vasodilator effect. However, little is known regarding the potential vascular activity of irisin, and the mechanisms underlying its effects on vascular smooth muscle have not been fully elucidated. This study was aimed to investigate the effects of irisin on vascular smooth muscle contractility in rat thoracic aorta, and the hypothesis that protein kinase C (PKC) may have a role in these effects. Materials and methods: Isometric contraction-relaxation responses of thoracic aorta rings were measured with an isolated organ bath model. The steady contraction was induced with …

Evaluation Of The Frequency And Intensity Of Covid-19 In Patients With Ankylosingspondylitis Under Anti-Tnf Therapy, Sümeyye Merve Türk, Zeynep Öztürk, Damla Karataş, Ünal Erkorkmaz, Emel Gönüllü

Turkish Journal of Medical Sciences

No abstract provided.

Evaluation Of Irrational Drug Use Of Individuals Over The Age Of 18 Who Applied To Auniversity Hospital, Sevi̇l Özger İlhan, Mücahi̇t Yildiz, Hakan Tüzün, Asi̇ye Uğraş Di̇kmen

Turkish Journal of Medical Sciences

Background/aim: Irrational drug use not only causes a delay in the treatment of patients, failure to achieve full well-being, drug interactions and side effects, drug resistance but also creates economic negativities such as waste of resources and unnecessary workload. This study aims to investigate the irrational drug use behaviors of individuals over the age of 18 who applied to a university hospital. Materials and methods: This sectional study included 1247 people over the age of 18 who applied for Gazi University Health, Research and Application Center. A questionnaire was applied to the applicants by face-to-face interview technique. Logistic regression analysis …

Pasireotide Treatment In Cushing's Disease: A Single Tertiary Center's Experience, Serdar Şahi̇n, Gular Kari̇mova, Şeyda Gül Özcan, Emre Durcan, Hande Mefkure Özkaya, Pinar Kadioğlu

Turkish Journal of Medical Sciences

Background/aim: Cushing's disease (CD), which cannot be controlled by surgery, requires medical treatment. In this situation, treatments with long-term effectiveness and safety profiles are needed. We aimed to evaluate the effects and adverse effects of pasireotide treatment in CD. Materials and methods: Patients who were followed up for CD and treated with pasireotide between 2014-2020 at Cerrahpaşa Medical Faculty, were evaluated retrospectively. The efficacy and adverse effects of pasireotide were evaluated in this study. Results: Thirty-two patients were evaluated. The mean duration of treatment was 26.5 [range, 12.0-37.0] months. The 24-h urinary free cortisol (UFC) decreased 46% during the treatment …

Endocarditis-Tr: Diagnosis, Treatment, And Prognosis Of The Infective Endocarditispatients Admitting Tertiary Centres Of Turkey, Ali̇ Nazmi̇ Çalik, Fatma Özlem Arican Özlük, Mehmet Baran Karataş, Yi̇ği̇t Çanga, Semi̇h Eren, Görkem Ayhan, Ayşe Sünbül, Ali̇ Pali̇ce, Aytaç Candemi̇r, Şükrü Akyüz, Mehdi̇ Zoghi̇, Ömer Kozan

Turkish Journal of Medical Sciences

Background/aim: Infective endocarditis (IE) is still a significant cause of morbidity and mortality among cardiovascular diseases. ENDOCARDITIS-TR study aims to evaluate the compliance of the diagnostic and therapeutic methods being used in Turkey with current guidelines. Materials and methods: The ENDOCARDITIS-TR trial is a multicentre, prospective, observational study consisting of patients admitted to tertiary centres with a definite diagnose of IE. In addition to the demographic, clinical, microbiological, and echocardiographic findings of the patients, adverse events, indications for surgery, and in-hospital mortality were recorded during a 2-year time interval. Results: A total of 208 IE patients from 7 tertiary centres …

Evaluation Of The Relationship Between Insulin Resistance And Visceral Adiposity Index Inpatients With Acne Vulgaris, İbrahi̇m Fuat Kayihan Kaya, M. Ali̇ Eryilmaz, Selma Pekgör, Orhan Külahci

Turkish Journal of Medical Sciences

Background/aim: Acne vulgaris (AV) is a chronic inflammatory skin disease that is common among adolescents. Its etiology involves hormones, diet, genetics, and environmental factors. The aim of this study was to investigate the association between acne vulgaris and insulin resistance (IR) and visceral adiposity index (VAI). Materials and methods: The study included 184 individuals. Participants' height, weight, waist and hip circumference and blood pressure were measured. Morning fasting blood was obtained from all participants for measuring glucose, insulin, triglyceride (TG), and cholesterol levels. The HOMA index and visceral adiposity index were calculated. The collected data were analyzed using statistical methods. …

The Role Of Leptin In Primary Sjögren Syndrome: A Clinical And Histopathologicalassessment Study, Mustafa Erdogan, Kayhan Basak, Mehmet Engin Tezcan

Turkish Journal of Medical Sciences

No abstract provided.

Turkey's Transition To Face-To-Face Schooling During The Covid-19 Pandemic, Mahmut Özer, Hayri̇ Eren Suna, Matjaz Perc, Sadri̇ Şensoy, Sevi̇l Uygun İli̇khan

Turkish Journal of Medical Sciences

Background/aim: The COVID-19 pandemic majorly disrupted conventional schooling and many countries maintained educational services through distance education. The duration of school closures in Turkey was longer than most OECD countries, thus Turkey prioritized school reopenings in the 2021-2022 academic year to mitigate possible negative outcomes of closures. Here we study the compatibility of implications for school reopenings in Turkey with these practices and assess the first semester of face-to-face schooling. Materials and methods: We have used document analysis to present and compare the practices in Turkey with international practices. We also used a comparative approach to assess the coherence between …

The Clinical Follow-Up And Management Of Covid-19 In Children And Adolescents Withan Immunocompromised State Or A Malignancy, İrem Ceren Erbaş, Hati̇ce Karaoğlu Asrak, Ayşe Çakil Güzi̇n, Şi̇lem Özdem Alataş, Şefi̇ka Akyol, Meral Torun Bayram, Refi̇k Emre Çeçen, Di̇lek İnce, Özlem Tüfekçi̇, Nurşen Belet

Turkish Journal of Medical Sciences

Background/aim: It is still not known how an immunosuppressive state affects the response to coronavirus disease 2019 (COVID-19) in children and adolescents. The aim of this study was to evaluate clinical characteristics, outcomes, and follow-up results of COVID-19 in pediatric patients with a history of immunocompromise or malignancy, retrospectively. Materials and methods: Patients with a diagnosis of COVID-19 who were under 18 years of age and had a history of immunosuppressive chronic disease or under immunosuppressant treatment were included in the study. Patients were applied to our outpatient clinic or consulted to our department in a tertiary center during the …

Pertussis Prevalence Among Adult Patients With Acute Cough, Ahmet İlbay, Mi̇ne Durusu Tanriöver, Işkin Pinar Zarakol, Ezgi̇ Çalişkan Güzelce, Hati̇ce Bölek, Serhat Ünal

Turkish Journal of Medical Sciences

Background/aim: Bordetella pertussis infection remains an important health problem in adults due to the increasing prevalence in recent years. Pertussis in adults can be easily overlooked or misdiagnosed. We aimed to determine the prevalence of pertussis in adult patients with acute cough and the clinical features of the pertussis cases. Materials and methods: Internal Medicine and Pulmonology inpatient wards and outpatient clinics were screened between March 2017 and June 2018. Patients with cough duration between 1 week and 1 month were enrolled. Those who were on antibiotics for more than 5 days were excluded. A total of 115 patients were …

The Validity And Reliability Study Of The Turkish Version Of Engagement In Healthy Ageing, Ramazan Kiraç, Seda Uyar, Mehmet Aki̇f Eri̇şen, Nur Feyzal Kesen

Turkish Journal of Medical Sciences

No abstract provided.

Determination Of Covid-19 Pcr Positivity And Mutation Status In Coronavacvaccinated Individuals In Turkey, Ahmet Çalişkan, Mücahi̇t Seçme, İlknur Kaleli̇, Tuğba Sari, Sedef Zeli̇ha Öner, Sani̇ye Küçükakin Yaka, Büşra Dönmez

Turkish Journal of Medical Sciences

Background/aim: CoronaVac is an inactivated virus-based COVID-19 vaccine used in Turkey and approved for emergency use by the World Health Organization (WHO). In this study, it was aimed to retrospectively evaluate the mutation status and clinical status in individuals who received two doses of CoronaVac vaccine and were infected with COVID-19 at least two weeks after the second dose. Materials and methods: 164 people were included in the study and COVID-19 diagnosis and mutation analyses were determined by RT-PCR using the Bioseepdy SARS CoV-2 Double Gene RT-qPCR Kit and the Biospeedy SARS-CoV-2 Variant Plus kit in accordance with the protocol …

The Efficacy Of Anakinra Compared To Standard Care Of Treatment For Covid-19: A Metaanalysis, Hamna Malik, Hira Bint Abdul Jabbar, Farah Latif, Azza Sarfraz, Zouina Sarfraz, Muzna Sarfraz

Turkish Journal of Medical Sciences

Background/aim: As SARS-CoV-2 continues to spread worldwide, this study brings to light the link that anakinra, a recombinant IL-1 receptor antagonist, has in averting grave clinical outcomes. The objectives of this meta-analysis are to investigate the effects of anakinra in interventional groups compared to control/standard of care groups on mortality along with the provision of a prevalence estimate of the variables associated with death (C-reactive protein-CRP, ferritin, acute respiratory distress syndrome-ARDS). Materials and methods: According to the PRISMA 2020 statement guidelines, a systematic search was conducted from December 19, 2020, until December 10, 2021, with keywords including COVID-19, coronavirus, SARS-CoV-2, …

An Evaluation Of The Results Of Convalescent Plasma Therapy Applied To Pregnant Womendiagnosed As Covid-19- Positive In A Pandemic Center: A Prospective Cohort Study, Seyi̇t Ahmet Erol, Atakan Tanaçan, Hakan Apaydin, Şule Göncü Ayhan, Deni̇z Oluklu, Derya Uyan Hendem, Serpi̇l Ünlü, Abdulsamet Erden, Özlem Moraloğlu Teki̇n, Ahmet Omma, İhsan Ateş, Orhan Küçükşahi̇n, Di̇lek Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: Convalescent plasma (CP) might be an additional treatment modality in COVID-19. The aim of this study was to compare CP-related clinical characteristics and perinatal outcomes in pregnant women with mild or moderate-severe COVID-19. Materials and methods: This prospective cohort study included 36 pregnant women (12 mild and 24 moderate-severe), who underwent CP therapy. The CP obtained from recently recovered donors was transfused to patients together with maximum supportive care and antiviral agents. The groups were then compared in respect of clinical characteristics, laboratory parameters, obstetric complications, and neonatal outcomes. Results: Significant differences were determined between the groups in respect …

Analgesic Efficacy Of Ultrasound Guided Unilateral Erector Spinae Plane Block For Laparoscopic Inguinal Hernia Repair: A Randomized Controlled Study, Savaş Altinsoy, Derya Özkan, Fatma Kavak Akelma, Jüli̇de Ergi̇l

Turkish Journal of Medical Sciences

No abstract provided.

Arthroscopic Bankart Repair Improves Upper Limb Exercise Capacity, Shoulder Function And Quality Of Life, Fi̇gen Dağ, Fehmi̇ Volkan Öztuna, Di̇dem Deri̇ci̇ Yildirim, Özlem Bölgen Çi̇men

Turkish Journal of Medical Sciences

No abstract provided.

Comparison Of Geriatric Nutritional Risk Index And Creatinine Index In Short-Term Mortality Prediction In Maintenance Hemodialysis Patients, Fatma Ayerden Ebi̇nç, Gülay Ulusal Okyay, Serpi̇l Müge Değer, Hati̇ce Şahi̇n, Tamer Selen, Çi̇se Kanar Doğan, Kadi̇r Gökhan Atilgan, Ebru Gök Oğuz, Mehmet Deni̇z Ayli

Turkish Journal of Medical Sciences

No abstract provided.

Oncometabolites In Urine-A New Opportunity For Detection And Prognosis Of The Clinical Progress Of Verified Prostate Cancer-A Pilot Study, Dimitar Delkov, Lyubka Yoanidu, Desislav Tomov, Rumyana Stoyanova, Ivan Dechev, Yordanka Uzunova

Turkish Journal of Medical Sciences

No abstract provided.

Test-Retest Reliability And Minimal Detectable Change For Measures Of Wearable Gait Analysis System (G-Walk) In Children With Cerebral Palsy., Melek Volkan Yazici, Gamze Çobanoğlu, Gökhan Yazici

Turkish Journal of Medical Sciences

No abstract provided.

Melanocytes As The Source Of The Increased Melanisation In Pigmented Epithelial Tumours: A Holistic Approach, Asuman Ki̇li̇tci̇, Ömer Faruk Elmas, Necmetti̇n Akdeni̇z, Mehmet Gamsizkan

Turkish Journal of Medical Sciences

No abstract provided.

Effectiveness Of A Supervised Group Exercise Therapy Based On The Biopsychosocial Model Introduced Simultaneously With Anti-Tnf Therapy In Anti-Tnf-Naive Patients With Active Ankylosing Spondylitis, Nur Banu Karaca, Edi̇be Ünal, Jale Karakaya, Umut Kalyoncu, Sedat Ki̇raz

Turkish Journal of Medical Sciences

No abstract provided.

Making Connections To Address Mathematics Anxiety: A Case Study Of The Instructional Triangle And Remedial College Instructors, Njeri M. Pringle, Jamie L. Workman, Meagan C. Arrastia-Chisholm

Georgia Educational Researcher

Mathematics anxiety is a reality for many students as a number of community college and four-year university students feel disconnected from math and struggle to pass mathematics courses. Using a case study and grounded theory approach, six remedial mathematics instructors were interviewed and observed to examine their instructional strategies and practices. During the interviews, participants expounded upon the changes in strategies and practices implemented when aiding students struggling with anxiety. The Instructional Triangle was applied across participants to compare and contrast their experiences. The analysis focused on environmental factors that could increase or exacerbate mathematics anxiety. In particular, a theme …

Peer-Coaching Based Professional Development: A Sample Of A School Of Foreign Languages, Sinem Arslan Dönmez, Ahmet Şahin Assoc. Prof.

Georgia Educational Researcher

The purpose of this study is to investigate the views of lecturers about the effectiveness of the implementation of the peer-coaching practice conducted at the school of foreign languages of a foundation university. The lecturers who took part in the peer coaching practice in the academic year 2019-2020 acted as the participants in this case study. The qualitative data was collected via interviews and document analysis. Content analysis and descriptive analysis methods were used in the process of data analysis. The findings from the analysis showed that peer-coaching practice consisted of lesson observations, pre and post-observation meetings, and reflection stages. …

Virtual Currencies In The Eurosystem: Challenges Ahead, Rosa Maria Lastra, Jason Allen Grant

The International Lawyer

No abstract provided.

The Single-Subject Rule And The Politics Of Constitutional Amendment In Initiative States, Jonathan L. Marshfield

Nebraska Law Review

Eighteen states allow citizens to independently propose constitutional amendments through the initiative process.1 In many of those states, the constitutional initiative is a powerful force in state constitutional politics.2 Indeed, since 2000, voters have considered hundreds of initiative amendments addressing a wide range of issues, including marriage equality, taxation, environmental policy, marijuana, infrastructure, education, agriculture, religious freedom, reproductive rights, affirmative action, immigration, redistricting, and many others.3 Initiative campaigns also attract a lot of money. In 2020, statewide campaigns reported $1.24 billion in contributions and $1.22 billion in spending.4 It should be unsurprising, therefore, that regulating the initiative is both important …

The Separation Of Legislative Powers In The Initiative Process, Anthony Johnstone

Nebraska Law Review

Direct democracy cannot implement itself. From Nebraska’s introduction of a state law authorizing the initiative at the local level in 1897,1 through the first constitutional amendments authorizing state-wide initiative processes in several states at the turn of the Twentieth Century, and subsequent efforts to expand the initiative power to approximately half the states,2 legislatures must share the legislative power with the people in states that provide the initiative. After the initial allocation of legislative power to initiative processes, usually through relatively detailed constitutional provisions, state legislatures become responsible for supporting the initiative power. In authorizing initiatives, state constitutions also authorize …

The Hijacking: The Remnants Of Morrissey-Wolff Due Process In Solitary Confinement After Sandin V. Conner, Russell E. Lovell Ii

Nebraska Law Review

Fifty years ago, in 1972, the United States Supreme Court, in an opinion by its new Chief Justice Warren Burger, issued a landmark prisoners’ rights decision in Morrissey v. Brewer.1 It involved the constitutionality of a parole board’s revocation of paroles without a hearing, an issue that I had considerable involvement in during my law Legal Services Organization (LSO) of Indianapolis—including coauthoring an amicus curiae brief on behalf of Morrissey while the case was pending before the Supreme Court. The fiftieth anniversary of the Morrissey decision has provided the occasion to write a retrospective on the historic decision and …

Matching Extendability In Cartesian Products Of Cycles, Jennifer Vandenbussche, Erik E. Westlund

Faculty Articles

In a bipartite graph G, a set (Formula presented) is deficient if |N(S)| < |S|. A matching M with vertex set U is k-suitable if G − U has no deficient set of size less than k. Define the extremal function fk (G) to be the largest integer r such that every k-suitable matching in G with at most r edges extends to a perfect matching. Let G(2m)d be the d-fold Cartesian product of the cycle C2m,wherem ≥ 2. We extend results of Vandenbussche and West by showing that for any integers k and d such that (Formula presented), except when m =2 and d =1.

A Student’S Access To Practice-Linked Resources In An Elementary Unplugged-To-Plugged Computer Science Unit, Umar Shehzad, Jody Clarke-Midura, Victor R. Lee, Mimi Recker

Publications

This paper presents a case study of a student’s participation in an expansively-framed unplugged computer science (CS) instructional unit that leverages activities and materials not typically associated with CS: playing an “unplugged” tabletop board game and designing a paper prototype of a new game level. We use the practice-linked identity framework as a lens to characterize resources available in our instructional design and how they afforded or hindered the student’s participation across the instructional activities. Our findings highlight the importance of relational resources in influencing participation, both positively and negatively, and provide implications for the design of future CS learning …

A Language For The World: The Standardization Of Swahili, Morgan J. Robinson

Ohio University Press Open Access Books

This intellectual history of Standard Swahili explores the long-term, intertwined processes of standard making and community creation in the historical, political, and cultural contexts of East Africa and beyond.

Morgan J. Robinson argues that the portability of Standard Swahili has contributed to its wide use not only across the African continent but also around the globe. The book pivots on the question of whether standardized versions of African languages have empowered or oppressed. It is inevitable that the selection and promotion of one version of a language as standard—a move typically associated with missionaries and colonial regimes—negatively affected those …