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Examination Of Diaphragm Thickness, Mobility And Thickening Fraction In Individuals With Copd Of Different Severity, Ceyhun Topcuoğlu, Eylem Tütün Yümi̇n, Mustafa Hizal, Suat Konuk Jan 2022

Examination Of Diaphragm Thickness, Mobility And Thickening Fraction In Individuals With Copd Of Different Severity, Ceyhun Topcuoğlu, Eylem Tütün Yümi̇n, Mustafa Hizal, Suat Konuk

Turkish Journal of Medical Sciences

Background/aim: Diaphragm thickness and mobility assessed by ultrasound in individuals with Chronic Obstructive Pulmonary Disease (COPD) reflect the function of the diaphragm. The aim of this study is to compare the diaphragm thickness, mobility, and thickening fraction in individuals with COPD of different severity and healthy individuals and examine the relationship between these parameters and pulmonary function test parameters. Materials and methods: A cross-sectional observational study design was used. Thirty individuals (mild = 11; moderate = 13; severe = 6) with COPD and 29 healthy male individuals aged between 40-75 years were included in the study. The individuals included in …

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Analysis Of The Relationship Between Tuberculosis-Related Mortality And Nitrous Oxide Emission Levels In The World With The Environmental Kuznets Curve Method, Şeri̇fe Torun, Kadi̇r Yilmaz, Şevket Özkaya, Şebnem Yosunkaya, Müşerref Şule Akçay Jan 2022

Analysis Of The Relationship Between Tuberculosis-Related Mortality And Nitrous Oxide Emission Levels In The World With The Environmental Kuznets Curve Method, Şeri̇fe Torun, Kadi̇r Yilmaz, Şevket Özkaya, Şebnem Yosunkaya, Müşerref Şule Akçay

Turkish Journal of Medical Sciences

Background/aim: It was aimed to analyze the relationship between tuberculosis-related mortality and nitrous oxide emission levels in the world with the Environmental Kuznets Curve (EKC) Method. Materials and methods: WHO ICD-10 mortality list data and the World Bank Country Data (WBCD) were used between 1997 and 2017 for 12 countries. Cubic regression analysis was used for EKC Analysis. Results: The difference between male and female deaths between 1996 and 1998 has increased sharply since 1999. Male deaths consistently occurred significantly more than female deaths. There was a significant and negative correlation between Nitrous oxide emissions (% change from 1990) and …

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Alpha-Lipoic Acid Prevents Atrial Electrical And Structural Remodeling Via Inhibition Of Nadph Oxidase In A Rabbit Rapid Atrial Pacing Model, Lei Chen, Wen Gao, Yameng Shao, Chenggang Li, Yuan Lu Jan 2022

Alpha-Lipoic Acid Prevents Atrial Electrical And Structural Remodeling Via Inhibition Of Nadph Oxidase In A Rabbit Rapid Atrial Pacing Model, Lei Chen, Wen Gao, Yameng Shao, Chenggang Li, Yuan Lu

Turkish Journal of Medical Sciences

Background/aim: Alpha-lipoic acid (ALA) is a natural compound, one of the natural antioxidants with high activity. In the NADPH oxidase family, NADPH oxidase 4 (NOX4) is an important subunit participating in the production of ROS. NADPH oxidase 2 (NOX2) can form active NADPH oxidase complexes when binding to several other subunits in the cytoplasm, and NOX2 is its major functional subunit. Rapid atrial pacing (RAP) model was constructed to study the effects of ALA on electrical and structural remodeling in rabbits. Materials and methods: Thirty rabbits were divided into SHAM group, RAP group and ALA+RAP group. Their right atriums were …

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Efficacy Of Transcranial Magnetic Stimulation In Treatment-Resistant Depression, Kemal Akpinar, Nalan Kalkan Oğuzhanoğlu, Tuğçe Toker Uğurlu Jan 2022

Efficacy Of Transcranial Magnetic Stimulation In Treatment-Resistant Depression, Kemal Akpinar, Nalan Kalkan Oğuzhanoğlu, Tuğçe Toker Uğurlu

Turkish Journal of Medical Sciences

Background/aim: The use of Transcranial Magnetic Stimulation (TMS) in the add-on treatment of patients with treatment-resistant depression (TRD) is becoming more common. This study aims to investigate the efficacy of TMS on depression and accompanying anxiety symptoms among patients with TRD. Materials and methods: The current study was conducted with 38 patients diagnosed with TRD. The patients were randomly divided into two groups and received 20 sessions of high-frequency (10Hz) TMS and 20 sessions of sham TMS to the left dorsolateral prefrontal cortex in a double-blind and cross-over fashion without a change in their pharmacotherapy. In the clinical evaluation, Hamilton …

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Evaluation Of Toxic Effects Of Dapagliflozin On Reproductive System In Diabetic Rats, Bahar Karaca, Tuğçe Boran, Ayça Karagöz Köroğlu, Feri̇ha Ercan, Gül Özhan Jan 2022

Evaluation Of Toxic Effects Of Dapagliflozin On Reproductive System In Diabetic Rats, Bahar Karaca, Tuğçe Boran, Ayça Karagöz Köroğlu, Feri̇ha Ercan, Gül Özhan

Turkish Journal of Medical Sciences

Background/aim: Dapagliflozin (DAPA), sodium-glucose cotransporter 2 (SGLT2) inhibitor, is an insulin-independent antidiabetic drug used to control hyperglycaemia by promoting glucose excretion from the kidney. Its adverse effects include orthostatic hypotension, dehydration and urinary tract and genital infections caused by glycosuria. DAPA is subjected to constant additional monitoring, as drugrelated adverse reactions are frequently updated in line with the results of case studies, clinical trials and in vivo studies. Some antidiabetic drugs have shown potential harmful effects on the male reproductive system; however, the effects of DAPA have not been sufficiently studied in this capacity. Aiming to fill this gap in …

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Interrupted Processing Of Paired Somatosensory Stimuli In Short Interstimulus Intervals: Role Of Thalamo-Cortical Oscillations, Nermi̇n Tepe, Hürrem Evren Boran, Sali̇h Geduk, Ergi̇n Di̇leköz, İlkay Ulusoy, Hayrunni̇sa Bolay Belen Jan 2022

Interrupted Processing Of Paired Somatosensory Stimuli In Short Interstimulus Intervals: Role Of Thalamo-Cortical Oscillations, Nermi̇n Tepe, Hürrem Evren Boran, Sali̇h Geduk, Ergi̇n Di̇leköz, İlkay Ulusoy, Hayrunni̇sa Bolay Belen

Turkish Journal of Medical Sciences

Background/aim: Discrimination of consecutive sensory stimuli is imperative for proper sensory perception and behavioral response. We aimed to investigate the emergence of paired somatosensory responses in relation to the interstimulus interval (ISI) change. Materials and methods: Paired stimulus with 35 ms, 50 ms, 80 ms, 140 ms, and 500 ms ISI was applied to the median nerve and evoked responses were recorded from the primary somatosensory cortex in rats. Early and late components of both responses were analyzed in different frequency bands. Results: The amplitudes were comparable for the 1st responses (S1), while the amplitude of the 2nd responses (S2), …

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Effects Of Different Scar Types On Flap Viability In A Skin Flap Model: An Experimental Study, Ceyhun Uzun, Can İlker Demi̇r, Emrah Kağan Yaşar, Mehdi̇ Asadov, Murat Şahi̇n Alagöz, Esra Ci̇vri̇z, Çi̇ğdem Vural Jan 2022

Effects Of Different Scar Types On Flap Viability In A Skin Flap Model: An Experimental Study, Ceyhun Uzun, Can İlker Demi̇r, Emrah Kağan Yaşar, Mehdi̇ Asadov, Murat Şahi̇n Alagöz, Esra Ci̇vri̇z, Çi̇ğdem Vural

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study was to investigate the use of tissues with multiple traumas, scarred pedicles, and medial scarring as a flap. Materials and methods: Forty-eight rats were randomly divided into four equal groups. The modified McFarlane flap was chosen as the flap model. In Group 1 (control), a dorsal skin flap was elevated and then sutured back into original position. In the other groups, a two-phase procedure was used. In Group 2 (pedicle incision), scar tissue was created with a skin incision at the prospective pedicle site of the flap and then sutured to its original site. …

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Low-Dose Valacyclovir Use With Preemptive Monitoring In Kidney Transplant Recipients With Intermediate Cytomegalovirus Infection Risk, Arzu Veli̇oğlu, Selma Alagöz, Di̇lek Barutçu Ataş, İzzet Hakki Arikan, Ebru Aşicioğlu, Mehmet Burak Aksu, Nurhan Seyahi̇, Zübeyde Serhan Tuğlular Jan 2022

Low-Dose Valacyclovir Use With Preemptive Monitoring In Kidney Transplant Recipients With Intermediate Cytomegalovirus Infection Risk, Arzu Veli̇oğlu, Selma Alagöz, Di̇lek Barutçu Ataş, İzzet Hakki Arikan, Ebru Aşicioğlu, Mehmet Burak Aksu, Nurhan Seyahi̇, Zübeyde Serhan Tuğlular

Turkish Journal of Medical Sciences

No abstract provided.

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Cover And Contents Jan 2022

Cover And Contents

Turkish Journal of Medical Sciences

No abstract provided.

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Highlights In The Association Of Fragmented Qrs With Myocardial Fibrosis, Mehmet Eyüboğlu Jan 2022

Highlights In The Association Of Fragmented Qrs With Myocardial Fibrosis, Mehmet Eyüboğlu

Turkish Journal of Medical Sciences

No abstract provided.

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Erector Spinae Plane Block In Chronic Pain: A Retrospective Study, Hanzade Aybüke Ünal Artik, Türkan Gülpinar, Adem Hali̇s, Nalan Çelebi̇ Jan 2022

Erector Spinae Plane Block In Chronic Pain: A Retrospective Study, Hanzade Aybüke Ünal Artik, Türkan Gülpinar, Adem Hali̇s, Nalan Çelebi̇

Turkish Journal of Medical Sciences

Patients with various aetiology of pain who underwent erector spinae plane block at different levels were evaluated at the tertiary Algology clinic. Visual analog scale (VAS) values were recorded before the block; 30 min, two weeks, and two months after the block. Medical records of fifteen patients have been obtained. The average VAS decreased from 7 ± 1 to 5 ± 3 in the second month when compared to the values before block (p < 0.01). ESP block can be an option for chronic pain in postsurgical pain syndrome and myofascial pain management.

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Androgenic Hormones In Crustacean Aquaculture: A Review, Muzaffer Mustafa Harlioğlu, Ardavan Farhadi̇ Jan 2022

Androgenic Hormones In Crustacean Aquaculture: A Review, Muzaffer Mustafa Harlioğlu, Ardavan Farhadi̇

Turkish Journal of Zoology

Increased demands of the seafood market have led to the rapid growth in crustacean aquaculture production in various parts of the world. Therefore, an expansion in the knowledge of the reproductive biology of crustaceans has become more important. Hormones released from the androgenic gland (AG) in crustaceans are liable for both the separation of primary and secondary sexual features and reproductive behavior. AG removal in male crustaceans causes a transformation of the intersex animals towards the females and a degeneration of spermatids and reproductive organs. AG implantation and injection of AG extracts are common approaches for crustacean masculinization. In this …

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Microglial Iron Trafficking: New Player In Brain Injury, Elif Keles, Hasan Hüseyi̇n Kazan, Lati̇fe Arzu Aral, Hayrunni̇sa Bolay Belen Jan 2022

Microglial Iron Trafficking: New Player In Brain Injury, Elif Keles, Hasan Hüseyi̇n Kazan, Lati̇fe Arzu Aral, Hayrunni̇sa Bolay Belen

Turkish Journal of Medical Sciences

Neonatal brain injury is a significant reason of neurodevelopmental abnormalities and long-term neurological impairments. Hypoxic-ischemic encephalopathy and preterm brain injury, including intraventricular hemorrhage are the most common grounds of brain injury for full-term and preterm neonates. The prevalence of hypoxic ischemic encephalopathy varies globally, ranging from 1 to 3.5/1000 live births in high-resource countries and 26/1000 in low-resource countries. Preterm birth's global incidence is 15 million, a significant reason for infant mortality and morbidity, permanent neurologic problems, and the associated social and economic burden. The widespread neurodevelopmental effects of neonatal brain injury could have an unfavorable impact on a variety …

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Complementary Medicines Used In Ulcerative Colitis And Unintended Interactions With Cytochrome P450-Dependent Drug-Metabolizing Enzymes, Alaatti̇n Şen Jan 2022

Complementary Medicines Used In Ulcerative Colitis And Unintended Interactions With Cytochrome P450-Dependent Drug-Metabolizing Enzymes, Alaatti̇n Şen

Turkish Journal of Medical Sciences

Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease with multiple genetic and a variety of environmental risk factors. Although current drugs significantly aid in controlling the disease, many people have led to the application of complementary therapies due to the common belief that they are natural and safe, as well as due to the consideration of the side effect of current drugs. Curcumin, cannabinoids, wheatgrass, Boswellia, wormwood and Aloe vera are among the most commonly used complementary medicines in UC. However, these treatments may have adverse and toxic effects due to unintended interactions with drugs or drugmetabolizing enzymes such …

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Circulating Mir-200c And Mir-33a May Be Used As Biomarkers For Predicting High Fructose Corn Syrup-Induced Fatty Liver And Vitamin D Supplementation-Related Liver Changes, Alpaslan Tanoğlu, Eylem Çağiltay, Esra Güzel Tanoğlu, Ayli̇n Gökhan, Cansin Şi̇ri̇n, Türker Çavuşoğlu, Recep Soner Yeşi̇lbaş Jan 2022

Circulating Mir-200c And Mir-33a May Be Used As Biomarkers For Predicting High Fructose Corn Syrup-Induced Fatty Liver And Vitamin D Supplementation-Related Liver Changes, Alpaslan Tanoğlu, Eylem Çağiltay, Esra Güzel Tanoğlu, Ayli̇n Gökhan, Cansin Şi̇ri̇n, Türker Çavuşoğlu, Recep Soner Yeşi̇lbaş

Turkish Journal of Medical Sciences

Background/aim: Nonalcoholic fatty liver is one of the most common forms of liver disease and role of microRNAs (miRNAs) on this illness is currently unclear. It was aimed to evaluate the predictive role of circulating miR-33a and mir-200c on high fructose corn syrup (HFCS)-induced fatty liver and vitamin D3 supplementation-related hepatic changes. Materials and methods: Twenty-four rats were randomized into three groups: sham (n = 8), experimental fatty liver group (n = 8), and fatty liver + vitamin D3 supplementation group (n = 8). In the treatment group, 10 µg/kg/week of vitamin D3 was given by orogastric tube weekly for …

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Impact Of Atp Synthase/Coupling Factor 6 In Hypoxic Pulmonary Arterial Hypertension: An Experimental Rat Model, Nannan Li, Yugen Shi, Jie Yin, Li Sun, Qingshan Zhang, Shuai Bao, Juan Zhang, Youlei Li, Miaomiao Wang, Yanwei Zhang, Mei Xue, Lei Qi, Yan Li, Suhua Yan, Xiaolu Li Jan 2022

Impact Of Atp Synthase/Coupling Factor 6 In Hypoxic Pulmonary Arterial Hypertension: An Experimental Rat Model, Nannan Li, Yugen Shi, Jie Yin, Li Sun, Qingshan Zhang, Shuai Bao, Juan Zhang, Youlei Li, Miaomiao Wang, Yanwei Zhang, Mei Xue, Lei Qi, Yan Li, Suhua Yan, Xiaolu Li

Turkish Journal of Medical Sciences

Background/aim: Hypoxia-induced pulmonary arterial hypertension (PAH) is characterized by prostacyclin (PGI2 ) disorder, which manifests in the same manner as in monocrotaline (MCT)-induced PAH. Endogenous PGI2 inhibitor coupling factor 6 (CF6) is involved in MCT-induced PAH. This study aimed to explore the presence or absence of a correlation between hypoxia-induced PAH and CF6. Materials and methods: This study was conducted between January 2019 and June 2020. A total of 135 male Wistar rats (aged 8 weeks and weighing 200?250 g) were randomly divided into five groups: (A) control, (B) 1 week of hypoxia, (C) 2 weeks of hypoxia, (D) 3 …

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Dynamics Of A Western Anatolian Population Of Natrix Natrix And Natrix Tessellata(Serpentes: Natricidae), Yusuf Bayrakci, Di̇nçer Ayaz Jan 2022

Dynamics Of A Western Anatolian Population Of Natrix Natrix And Natrix Tessellata(Serpentes: Natricidae), Yusuf Bayrakci, Di̇nçer Ayaz

Turkish Journal of Zoology

Due to their secretive nature, snakes are the most challenging animal group for monitoring. Nevertheless, population size estimates are indispensable to accurately determining conservation status and management strategies. We used passive integrated transponder (PIT) tags to track aquatic snakes Natrix natrix and Natrix tessellata in Lake Işıklı, Denizli province, Turkey. 304 N. natrix and 1563 N. tessellata specimens were captured and marked over the four-year sampling period. Of the marked individuals, 14 N. natrix and 97 N. tessellata were recaptured at least once. The three-year average population size was estimated at 1940 ± 1055 for N. natrix, and 10,146 ± …

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Determination Of Mir-373 And Mir-204 Levels In Neuronal Exosomes In Alzheimer?S Disease, Eli̇fcan Taşdelen, Erguvan Tuğba Özel Kizil, Sabi̇ha Tezcan Aydemi̇r, Ömer Eray Yalap, Ayşe Petek Bi̇ngöl, Nüket Kutlay Jan 2022

Determination Of Mir-373 And Mir-204 Levels In Neuronal Exosomes In Alzheimer?S Disease, Eli̇fcan Taşdelen, Erguvan Tuğba Özel Kizil, Sabi̇ha Tezcan Aydemi̇r, Ömer Eray Yalap, Ayşe Petek Bi̇ngöl, Nüket Kutlay

Turkish Journal of Medical Sciences

Background/aim: NLRP3 inflammasome activation has been known to be involved in the etiology and progression of Alzheimer?s disease (AD). Furthermore, AD and diabetes mellitus have common pathomechanisms. It has been shown that P2X7R whose expression is increased in brain tissues with AD and plays a role in the activation of NLRP3 inflammasome is suppressed by miR-373 in patients with osteoarthritis. Therefore, the question of whether the suppressive effect of miR-373 on NLRP3 may have a role in the pathophysiology of AD comes to mind. On the other hand, it is known that the miR-204 level increases in response to TXNIP, …

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Identification Of Sepsis-Associated Encephalopathy Risk Factors In Elderly Patients: A Retrospective Observational Cohort Study, Guangyong Jin, Shengyun Wang, Jiayi Chen, Wei Hu, Ying Zhu, Shaosong Xi Jan 2022

Identification Of Sepsis-Associated Encephalopathy Risk Factors In Elderly Patients: A Retrospective Observational Cohort Study, Guangyong Jin, Shengyun Wang, Jiayi Chen, Wei Hu, Ying Zhu, Shaosong Xi

Turkish Journal of Medical Sciences

Background/aim: Sepsis-associated encephalopathy (SAE) is a severe complication of sepsis that affects upwards of half of all sepsis patients. Few studies have examined the etiology and risk factors of SAE among elderly patients. This study was designed to explore the epidemiology of SAE and the risk factors associated with its development in elderly populations. Materials and methods: This was a retrospective analysis of elderly sepsis patients admitted to our intensive care unit between January 2017 and January 2022. We then compared non-SAE and SAE groups concerning baseline clinicopathological findings, underlying diseases, infection site, disease type, disease severity, biochemical findings, and …

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Serum Visfatin Concentrations Are Positively Associated With Ventricular Arrhythmias: A Single-Center Preliminary Study, Rongrong Shen, Peiyu Zhang, Rong Guo, Yawei Xu Jan 2022

Serum Visfatin Concentrations Are Positively Associated With Ventricular Arrhythmias: A Single-Center Preliminary Study, Rongrong Shen, Peiyu Zhang, Rong Guo, Yawei Xu

Turkish Journal of Medical Sciences

Background/aim: Visfatin has been reported to be closely related to cardiovascular diseases associated with inflammation, but the correlation between visfatin and ventricular arrhythmia (VA) has not been discussed yet. The study aims to explore the association between serum visfatin concentrations and VA in patients. Materials and methods: Sixty-seven hospitalized patients diagnosed with VA and 131 control subjects were enrolled in this crosssectional study between May 20, 2017 and November 8, 2019. Classification of VA types was based on the presence of structural heart disease (SHD). The patients? blood samples were collected to examine their serum levels of visfatin. Results were …

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Comparison Of Anakinra And Tocilizumab In Management Of Severe Covid-19: A Retrospective Cohort Study, Orhan Küçükşahi̇n, Abdulsamet Erden, Özlem Karakaş, Serdar Can Güven, Berkan Armağan, Enes Seyda Şahi̇ner, Osman İnan, Ali̇ Can Kurti̇pek, Emi̇n Gemci̇oğlu, Selma Karaahmetoğlu, Sema Turan, Seval İzdeş, Deni̇z Erdem, Adalet Aypak, Müge Ayhan Jan 2022

Comparison Of Anakinra And Tocilizumab In Management Of Severe Covid-19: A Retrospective Cohort Study, Orhan Küçükşahi̇n, Abdulsamet Erden, Özlem Karakaş, Serdar Can Güven, Berkan Armağan, Enes Seyda Şahi̇ner, Osman İnan, Ali̇ Can Kurti̇pek, Emi̇n Gemci̇oğlu, Selma Karaahmetoğlu, Sema Turan, Seval İzdeş, Deni̇z Erdem, Adalet Aypak, Müge Ayhan

Turkish Journal of Medical Sciences

Background/aim: Studies regarding effectiveness of anakinra and tocilizumab treatments in coronavirus disease 2019 (COVID-19) have contradictory results. Furthermore, there is scarce comparative data regarding superiority of any agent. To further elucidate any superiority between these two agents, we retrospectively investigated and compared outcomes in hospitalized COVID-19 patients of our inpatient cohort who received anakinra or tocilizumab. Materials and methods: This study was designed as a single-center, retrospective, cross-sectional cohort study. Hospitalized patients with confirmed diagnosis of COVID-19 who had Brescia-COVID respiratory severity scale score ?3 and hyperinflammation (defined as elevation of C reactive protein ?50 g/L or ferritin ?700 ng/mL) …

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Brain Hypoxia Caused By Respiratory Obstruction Which Should Not Be Forgotten In Covid-19 Disease, Aleksandr Urakov, Nikita Muhutdinov, Ilnur Yagudin, Darya Suntsova, Milena Svetova Jan 2022

Brain Hypoxia Caused By Respiratory Obstruction Which Should Not Be Forgotten In Covid-19 Disease, Aleksandr Urakov, Nikita Muhutdinov, Ilnur Yagudin, Darya Suntsova, Milena Svetova

Turkish Journal of Medical Sciences

To the Editor,

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The Effect Of Frailty On The Development Of Acute Kidney Injury In Critically-Ill Geriatric Patients With Covid-19, Murat Küçük, Bi̇şar Ergün, Mehmet Nuri̇ Yakar, Özer Ural Çakici, Erdem Yaka, Bi̇lgi̇n Cömert, Ali̇ Necati̇ Gökmen, Begüm Ergan Jan 2022

The Effect Of Frailty On The Development Of Acute Kidney Injury In Critically-Ill Geriatric Patients With Covid-19, Murat Küçük, Bi̇şar Ergün, Mehmet Nuri̇ Yakar, Özer Ural Çakici, Erdem Yaka, Bi̇lgi̇n Cömert, Ali̇ Necati̇ Gökmen, Begüm Ergan

Turkish Journal of Medical Sciences

Background/aim: Acute kidney injury is strongly associated with mortality in critically ill patients with coronavirus disease 2019 (COVID-19); however, age-related risk factors for acute kidney injury are not clear yet. In this study, it was aimed to evaluate the effects of clinical factors on acute kidney injury development in an elderly COVID-19 patients. Materials and methods: Critically ill patients (?65years) with COVID-19 admitted to the intensive care unit were included in the study. Primary outcome of the study was the rate of acute kidney injury, and secondary outcome was to define the effect of frailty and other risk factors on …

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What Is The Protective Effect Of Preischemic Kisspeptin-10 Administration Against Ischemia/Reperfusion Injury Of Striatum On Mice?, Hati̇ce Akkaya, Engi̇n Sümer, Seli̇m Kutlu, Hati̇ce Solak, Bayram Yilmaz Jan 2022

What Is The Protective Effect Of Preischemic Kisspeptin-10 Administration Against Ischemia/Reperfusion Injury Of Striatum On Mice?, Hati̇ce Akkaya, Engi̇n Sümer, Seli̇m Kutlu, Hati̇ce Solak, Bayram Yilmaz

Turkish Journal of Medical Sciences

Background/aim: Kisspeptin is a neuropeptide with a primary role on the onset of puberty and has beneficial effects on ischemia/ reperfusion (I/R) injury. In this study, we aimed to investigate the effect of kisspeptin administration on striatal I/R injury in mice. Material and methods: Forty adult C57/BL6 mice were randomly divided into four groups: Sham, Kisspeptin, I/R, and I/R + Kisspeptin groups. The groups were administered with either physiological saline (Sham and I/R groups) or kisspeptin (Kisspeptin and I/R + Kisspeptin groups) intraperitoneally 40 min before the operation. A microdialysis probe was placed in the right striatum according to stereotaxic …

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Evaluation Of Coagulation With Teg In Patients Diagnosed Covid-19, Hülya Vatansev, Mehmet Ali̇ Karaselek, Resul Yilmaz, Serkan Küççüktürk, Ahmet Topal, Şebnem Yosunkaya, Adem Küçük, Celaletti̇n Vatansev Jan 2022

Evaluation Of Coagulation With Teg In Patients Diagnosed Covid-19, Hülya Vatansev, Mehmet Ali̇ Karaselek, Resul Yilmaz, Serkan Küççüktürk, Ahmet Topal, Şebnem Yosunkaya, Adem Küçük, Celaletti̇n Vatansev

Turkish Journal of Medical Sciences

Background and aim: A high D-dimer level may indicate the risk of coagulopathy and mortality in COVID-19 patients. Thromboelastography (TEG) is a test that evaluates clot formation and fibrinolysis in real-time, unlike routine coagulation tests. The study aimed to investigate the coagulation process with TEG in patients diagnosed with COVID-19. Materials and Methods: The study was performed at our university hospital, chest diseases outpatient clinic as a cross-section study. A total of 51 patients with 23 high D-dimer levels group (HDG) and 28 low D-dimers group (LDG) were included in the study. TEG analysis was performed at the pretreatment evaluation …

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A Covid-19 First Evaluation Clinic At A University Hospital In Turkey, Gülçi̇n Telli̇ Di̇zman, Gökhan Metan, Çağlayan Merve Ayaz Ceylan, Hayri̇ye Altunay, Mertcan Uzun, Gamze Gürsoy, Zahi̇t Taş, Gi̇zem Karahan, Fari̇da Ahmadova, Tuğba Saricaoğlu, Zeynep Cansu Çalişkan, Alpaslan Alp, Meli̇ha Çağla Sönmezer, Ahmet Çağkan İnkaya, Ahmet Görkem Er Jan 2022

A Covid-19 First Evaluation Clinic At A University Hospital In Turkey, Gülçi̇n Telli̇ Di̇zman, Gökhan Metan, Çağlayan Merve Ayaz Ceylan, Hayri̇ye Altunay, Mertcan Uzun, Gamze Gürsoy, Zahi̇t Taş, Gi̇zem Karahan, Fari̇da Ahmadova, Tuğba Saricaoğlu, Zeynep Cansu Çalişkan, Alpaslan Alp, Meli̇ha Çağla Sönmezer, Ahmet Çağkan İnkaya, Ahmet Görkem Er

Turkish Journal of Medical Sciences

Background/aim: We aimed to analyze the usefulness of such a reserved area for the admission of the patients' symptoms suggesting COVID-19 and compare the demographic and clinical characteristics of the patients with COVID-19 and without COVID-19 who were admitted to C1 during the first month of the COVID-19 outbreak in our hospital. Materials and methods: A new area was set up in Hacettepe University Adult Hospital to limit the contact of COVID-19 suspicious patients with other patients, which was named as COVID-19 First Evaluation Outpatient Clinic (C1). C1 had eight isolation rooms and two sampling rooms for SARS-CoV-2 polymerase-chain-reaction (PCR). …

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Evaluation Of Clinical And Laboratory Findings In Severe Group Covid-19 Pregnants Without Comorbidity, Fatma Bozkurt, Ömer Çoşkun, Sevda Yeleç, Muhammed Bekçi̇başi, Muhammet Asena, İhsan Bağli Jan 2022

Evaluation Of Clinical And Laboratory Findings In Severe Group Covid-19 Pregnants Without Comorbidity, Fatma Bozkurt, Ömer Çoşkun, Sevda Yeleç, Muhammed Bekçi̇başi, Muhammet Asena, İhsan Bağli

Turkish Journal of Medical Sciences

Background/aim: COVID - 19 disease may be seen with different clinical presentations in pregnant women. Comorbid diseases are important factors affecting the progression of this disease. In this study, we aimed to evaluate the clinical and laboratory findings in pregnant women with COVID - 19 who had no comorbid disease. Material and methods: This retrospective designed study included 217 patients with Covid PCR positive in typically COVID - 19 clinic. The patients were classified into asymptomatic, nonsevere, and severe disease groups. The symptoms, laboratory results, hospital follow- ups and intensive care records of the patients and the findings of new …

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Sars-Cov-2 Vaccine: First-Month Results Of A Six-Month Follow-Up Study, Burak Mete, Ferdi̇ Tanir, Hakan Demi̇rhi̇ndi̇, Ertan Kara, Fi̇li̇z Ki̇bar, Sali̇h Çeti̇ner, Aslihan Candevi̇r, Rabi̇a Adevi̇yye Dal Jan 2022

Sars-Cov-2 Vaccine: First-Month Results Of A Six-Month Follow-Up Study, Burak Mete, Ferdi̇ Tanir, Hakan Demi̇rhi̇ndi̇, Ertan Kara, Fi̇li̇z Ki̇bar, Sali̇h Çeti̇ner, Aslihan Candevi̇r, Rabi̇a Adevi̇yye Dal

Turkish Journal of Medical Sciences

Background/aim: Various COVID-19 vaccines are being developed around the world. Important questions to be answered regarding vaccines are efficacy, safety, and whether antibodies are protective when used in different communities. This study aimed to determine seroconversion rates of the inactivated SARS-CoV-2 vaccine in healthcare workers in a hospital and short-term adverse events due to the vaccine. Materials and methods: The study carried out in Çukurova University, Turkey, comprised of 282 healthcare workers who received two doses of the inactivated SARS-CoV-2 vaccine administered in two 3 μg doses, 28 days apart. On day 28, after the second dose, anti- S-RBD IgG …

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Interstitial Lung Disease In Patients With Systemic Lupus Erythematosus: A Cohort Study, Naci̇ Şenkal, Esen Kiyan, Ali̇ Aslan Demi̇r, Yasemi̇n Yalçinkaya, Ahmet Gül, Murat İnanç, Mahdume Lale Öçal, Bahar Artim Esen Jan 2022

Interstitial Lung Disease In Patients With Systemic Lupus Erythematosus: A Cohort Study, Naci̇ Şenkal, Esen Kiyan, Ali̇ Aslan Demi̇r, Yasemi̇n Yalçinkaya, Ahmet Gül, Murat İnanç, Mahdume Lale Öçal, Bahar Artim Esen

Turkish Journal of Medical Sciences

Background/aim: Systemic lupus erythematosus (SLE) is an autoimmune disease with a variety of organ/system involvement. Respiratory system involvement is common in these patients and usually manifests itself by disorders of the lung parenchyma, pleura, pulmonary vasculature or diaphragm. In this study, we sought to determine the frequency of interstitial lung disease (ILD) in patients with SLE and associated risk factors. Materials and methods: Three hundred randomly chosen patients with SLE were included. Chest x-ray (CXR), lung spirometry and carbon monoxide diffusion test (DLCO) were performed. High-resolution thorax computed tomography (HRCT) was performed for a definite diagnosis of ILD. Results: Of …

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Effect Of Tocilizumab On Intensive Care Patients With Covid-19 Pneumonia, A Retrospective Cohort Study, Mehtap Pehli̇vanlar Küçük, Ahmet Oğuzhan Küçük, Ayşegül Pehli̇vanlar, Emi̇ne Sevi̇l Ayaydin Mürtezaoğlu, Kadi̇r Çoban, Gamze Kiliç, Olcay Ayçi̇çek, Funda Öztuna, Yilmaz Bülbül, Tevfi̇k Özlü Jan 2022

Effect Of Tocilizumab On Intensive Care Patients With Covid-19 Pneumonia, A Retrospective Cohort Study, Mehtap Pehli̇vanlar Küçük, Ahmet Oğuzhan Küçük, Ayşegül Pehli̇vanlar, Emi̇ne Sevi̇l Ayaydin Mürtezaoğlu, Kadi̇r Çoban, Gamze Kiliç, Olcay Ayçi̇çek, Funda Öztuna, Yilmaz Bülbül, Tevfi̇k Özlü

Turkish Journal of Medical Sciences

Backround/aim: In this study, the efficacy of an IL-6 antagonist, Tocilizumab, administered in the early period was studied in intensive care patients with COVID-19 pneumonia followed by hypoxic and systemic inflammation not receiving mechanical ventilation support. Materials and methods: Patients with COVID-19 pneumonia who have signs of hypoxia and systemic inflammation and/or who have acute bilateral infiltrates on chest radiograph and who received tocilizumab treatment were compared with the patients who received standard medical therapy. Patients who were followed up with COVID-19 pneumonia and respiratory failure between March 2020 and March 2021 were retrospectively evaluated in the study. A 400 …

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