Digital Commons Network^™

Investigating The Effects Of Semaglutide On Hepatic Cytochrome P450 Enzyme Expression, Maanasi Bulusu, Kavya Vasudevan, Mir S. Adil Phd

DO Research Day

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist widely used to treat type 2 diabetes and obesity. Because many patients taking semaglutide also use other medications, understanding its potential effects on drug metabolism is important. Hepatic cytochrome P450 (CYP450) enzymes metabolize many commonly used medications, and changes in their expression may alter drug levels and treatment response. However, the effects of semaglutide on hepatic CYP450 expression remain poorly understood.: To determine whether semaglutide alters hepatic CYP450 enzyme expression and establish a human liver cell model for studying its potential effects on drug metabolism. Publicly available mouse gene expression data (GEO …

Investigating Monocyte–Endothelial Interactions: Development Of An In Vitro Model Of Doxorubicin-Associated Endothelial Dysfunction, Kiley Moore, Mikah Chandler, Trinity Soto, Samyuktha Athreya, Andrea Linares, Kavya Vasudevan, Mir S. Adil Phd

DO Research Day

Doxorubicin (DOX) is an effective chemotherapeutic agent whose clinical use is limited by cardiovascular toxicity. In addition to direct cardiomyocyte injury, vascular endothelial dysfunction may contribute to chemotherapy-associated cardiovascular injury. Our broader research investigates whether DOX-induced monocyte changes influence endothelial cells through secreted factors and potentially extracellular-vesicle-associated signaling. Preliminary data demonstrated that DOX increases human endogenous retrovirus-K (HERV-K) mRNA expression in THP-1 monocytes. We sought to establish an in vitro monocyte–endothelial conditioned-medium transfer model and identify appropriate controls for evaluating monocyte-derived effects on endothelial cells. THP-1 monocytes and EA.hy926 endothelial cells were cultured under optimized conditions. As an initial model-development …

Diabetes Mellitus And Wound Care Gaps Among Unhoused And Temporarily Housed Individuals In Knoxville, Tn, Andrew Tenaglia, Emily C. Wyatt, Danielle Darter

DO Research Day

Background: Individuals experiencing homelessness face disproportionately high rates of chronic disease and wound-related complications due to limited access to preventive healthcare, hygiene resources, and longitudinal medical management. Street medicine programs provide an opportunity to identify and treat wounds before progression to severe infection or operative intervention.

Objectives: To characterize the prevalence and distribution of diabetes mellitus and wound related conditions among patients receiving care through Knoxville Street Medicine Outreach (KSMO).

Method: A retrospective chart review was performed using de-identified electronic medical records from 604 patients treated by KSMO between June 12, 2024, and July 10, 2026. Patients with documented diabetes …

Prevalence Of Hypertension Among Unhoused And Temporarily Housed Individuals Receiving Street Medicine In Knoxville, Tennessee, Emily Wyatt, Andrew Tenaglia, Danielle Darter

DO Research Day

Background: Individuals experiencing housing instability are disproportionately affected by chronic diseases, including hypertension, yet often face significant barriers to preventive healthcare and longitudinal disease management. Street medicine programs provide healthcare directly to medically underserved populations, but limited data exist describing the prevalence of hypertension among patients receiving these services.

Objectives: To characterize the prevalence of hypertension among patients receiving care through Knoxville Street Medicine Outreach (KSMO) and describe the demographic characteristics and housing status of this population.

Method: A retrospective observational study was conducted using de-identified electronic medical records from KSMO. Patient encounters between June 2024 and July 2026 were …

Improving Medical Student Confidence And Preparedness: The Role Of Simulation-Based Education In Substance Use Disorder Care, Patricia Archambault, David Crabtree

DO Research Day

Substance use disorders (SUDs) remain a major public-health concern. In 2024, approximately 48.4 million Americans aged 12 years or older met criteria for a past-year SUD, yet only 12.3% received substance-use treatment.¹ Although addiction medicine education has expanded, undergraduate medical curricula remain variable, and medical students frequently report limited confidence in screening, counseling, and treating patients with SUDs. Traditional didactic instruction provides foundational knowledge but may offer insufficient opportunities to practice patient centered communication, trauma-informed care, and evidence-based treatment. Simulation-based education (including standardized patients) may help bridge this knowledge-to-practice gap by allowing students to apply clinical knowledge, practice communication, and …

Effect Of Three Nutraceutical Agents On The Metastatic Ability Of Prostate Cancer Cells: Quantitative Evaluation Of Scratch Wound Assay Findings, Michelle Nguyen, Mariam Bushra, Hunter Cole, Caden Cantrill, Debasis Mondal

DO Research Day

Background: Prostate Cancer (PCa) is a leading cause of morbidity and mortality in elderly men in the United States (US). Despite the availability of approved anticancer strategies, treatment related side effects and the recurrence of aggressive and metastatic cancer cells remain a formidable challenge. Therefore, the possible use of safety-tested nutraceuticals that can suppress PCa metastasis would be of great translational value. We have investigated the anti-metastatic effects of dimethyl sulfoxide (DMSO), methyl sulfonyl methane (MSM), and ethyl pyruvate (EP), three clinically tested natural compounds. Here, we document their ability, both alone and in combinations, to suppress PCa cell migration …

Beyond Anesthesia-Attributed Mortality: Access, Capability, And Reliability In Obstetric Anesthesia For Rural And Socioeconomically Disadvantaged Patients, Abdullah Salim, Tiffany Iheanacho, Sarah Kable

DO Research Day

Background & Objective

Anesthesia-related maternal mortality has declined substantially, yet cause-of-death attribution captures only a small part of the specialty’s contribution to maternal outcomes. Access barriers, low-volume care, workforce shortages, overstated facility readiness, and unreliable follow-up may shape risk before, during, and after delivery.

Objective: synthesize U.S. evidence using an Access → Capability → Reliability framework and ask: Can patients reach appropriate care? Can facilities deliver it? Is care delivered consistently and equitably?

Methods & Limitations

Methods: SANRA-informed narrative review of PubMed, Embase, Scopus, and Web of Science through June 2026. Search concepts included obstetric anesthesia, maternal mortality and morbidity, …

Effects Of Warm And Cold Ischemia On The Human Myocardium Over Time, Shawnaleh Cada, Kenneth Bedi, Eliot Peyster, Yoshikazu Suzuki, Surendra Dasari, Kenneth B. Margulies

DO Research Day

Background: Myocardial protection strategies employed in cardiac surgery and transplantation have centered around in situ cardioplegic arrest combined with hypothermic cooling to mitigate myocardial damage and reperfusion injury. The cardioplegic solution is delivered directly to the myocardium at 4°C, producing electromechanical silencing and reduced metabolic demand, while the patient is typically cooled systemically to ~33°C. In transplantation static cold storage at ~4°C has been the standard method for preserving donor hearts for the past 60 years. A handful of cardiac surgical reports have examined warm-ischemic myocardium, but the molecular trajectory of myocardium receiving neither protection (mimicking infarction or the warm …

Enhancing Brachial Plexus Education Through An Interactive, Coded Three-Dimensional Learning Model, Ambika Siddabathula, Erick Moberg, Ph.D

DO Research Day

The brachial plexus presents a persistent instructional challenge in anatomy education because students must integrate its branching organization with its three-dimensional relationships to surrounding structures.[1,2] Understanding the plexus requires learners to trace neural contributions through roots, trunks, divisions, cords, and terminal branches while recognizing their spatial relationships to the axillary artery.[2] Conventional diagrams can clarify connections between named structures, but translating these schematics into an anatomically coherent spatial representation remains a recognized teaching challenge.[1,2] These difficulties occur within a broader pattern of challenges in learning neuroanatomy. In a national survey of 2,877 medical students across 25 UK medical schools, respondents …

From Copilot To Care Plans: Integrating Genai Into Undergraduate Children’S Nursing Education. A Case Study, Lisa Kirwan, Tracey O'Neill

Irish Journal of Academic Practice

Generative artificial intelligence and large language models are influencing healthcare practice and education, offering benefits such as improved efficiency, decision support, and learning opportunities. However, concerns remain regarding the accuracy, bias, and ethical implications of AI-generated content, particularly in clinical decision-making contexts. Despite the growing presence of AI in healthcare, undergraduate nursing curricula often lack opportunities for students to develop AI literacy alongside clinical reasoning skills. This case study describes the design and implementation of an educational activity in which 22 children’s and general integrated nursing students used Microsoft CoPilot to generate and evaluate nursing care plans for children with …

Activity-Dependent Astrocytic Cholesterol Release Fine-Tunes Modes Of Synaptic Exo- And Endocytosis, Jongyun Myeong, Vitaly A Klyachko

2020-Current year OA Pubs

Cholesterol is essential for the organization of neurotransmitter release machinery, yet how it regulates the balance among different forms of synaptic exo- and endocytosis remains poorly understood. Moreover, which pre-synaptic processes rely on neuronal vs. astrocyte-derived cholesterol is unknown. Using nanoscale-precision imaging of single-vesicle release in hippocampal synapses, we demonstrate that astrocytic cholesterol is a critical determinant of both temporal and spatial aspects of presynaptic dynamics by differentially modulating the two main forms of synchronous release, univesicular (UVR) and multivesicular (MVR), effectively fine-tuning their balance. Moreover, astrocytic cholesterol determines the spatial distribution of vesicle release across the active zone and …

Study Of Blood Linear Rna Nominates Cd55 And Dld As Early-Stage Biomarkers For Parkinson's Disease, Aleksandra Beric, Sarp Sahin, Santiago Sanchez, Zining Yang, Ravindra Kumar, Isabel Alfradique-Dunham, Jessie Sanford, Daniel Western, Bridget Phillips, John P Budde, Richard J Perrin, Paul T Kotzbauer, Joel S Perlmutter, Scott A Norris, Carlos Cruchaga, Laura Ibanez

2020-Current year OA Pubs

Parkinson's disease (PD) is the second leading neurodegenerative disease, pathologically characterized by the accumulation of alpha-synuclein in the brain and the loss of dopaminergic neurons in the substantia nigra pars compacta. Despite the intensive efforts to identify diagnostic biomarkers for PD and nominating prospective candidates such as such as CSF α-synuclein seed amplification assay or α-/β-synuclein ratio, establishment of minimally invasive biomarkers remains the focus of PD research. We leveraged transcriptomic data from 4343 participants from four independent datasets to robustly identify PD-associated transcripts. Following the differential abundance analyses, we integrated our findings with several brain transcriptomic, CSF proteomic, plasma …

Jarvis V. Amazon.Com Inc

2026 Decisions

USDC for the District of New Jersey

Walter Reyes-Ayala V. Attorney General United States Of America

2026 Decisions

Agency

Trigeminal Neuralgia Versus Pulpitis In A Pregnant Patient: Challenges In Diagnosis And Endodontic Management—A Case Report, Ria Septina Rusli, Widi Prasetia

Journal of Dentomaxillofacial Science

Background: Trigeminal neuralgia (TN) is a rare but debilitating neuropathic pain disorder characterized by severe, electric shock-like facial pain that can significantly affect maternal quality of life and pregnancy outcomes. Most patients with TN are initially misdiagnosed as having odontogenic pain, leading to inappropriate dental treatment.
Objective: This case report aims to highlight how pregnancy-related hormonal changes, limitations in diagnostic procedures, and restricted therapeutic options influence the evaluation and management of TN during pregnancy.
Case Report: A 31-year-old woman in the eighth month of pregnancy presented with pain described as an electric shock-like sensation affecting the lower right side of …

Mapping The Intellectual Structure Of Green-Synthesized Nanoparticle Research In Dentistry: A Bibliometric Analysis, Nisrina E. Nasrun, H. Hasanuddin, Acing H. Mude, Muhammad Ikbal, Rifaat Nurrahma, Tsuyoshi Shimo

Journal of Dentomaxillofacial Science

Objective: Research on green-synthesized nanoparticles in dentistry has grown rapidly, yet remains synthesized mainly through narrative and scoping reviews without formal quantitative mapping. This study characterized publication trends, thematic clusters, geographic productivity, and the intellectual base of this field using bibliometric analysis and science mapping.
Methods: Records were retrieved from Scopus, PubMed, and Web of Science (English; 2006–2026) and screened against a three-element eligibility criterion (green/biogenic synthesis, a nanoparticle/nanomaterial study object, and an explicit dental/oral health context) following the BIBLIO checklist. After deduplication, screening, and indexing verification, 733 records (702 articles and 31 reviews) were retained. Annual growth, keyword co-occurrence, …

Immune Hallmarks Of Recurrent Immune Checkpoint Inhibitor-Mediated Inflammatory Arthritis, Synat Keam, Yuanteng Jeff Li, Yanshuo Chu, Jean H Tayar, Huifang Lu, Michael Wu, Sandeep K Agarwal, Nitin Jain, Pavlos Msaouel, Adi Diab, Linghua Wang, Cara Haymaker, Roza Nurieva, Sang T Kim

Faculty, Staff and Students Publications

Immune checkpoint inhibitor (ICI) therapy is often associated with immune-related adverse events including inflammatory arthritis (IA). However, the mechanisms underlying ICI-mediated IA (ICI-IA), especially its recurrence, are not well understood. In this study, we sought to elucidate mechanisms of recurrent ICI-IA by analyzing longitudinal synovial fluid (SF) samples from patients with ICI-IA. SF samples were collected from six patients with ICI-IA at the first and second occurrences of ICI-IA and analyzed with single-cell RNA sequencing (n = 3), single-cell T-cell receptor sequencing (n = 3), single-cell B-cell receptor sequencing (n = 3), and flow cytometry (n = 6). SF samples …

Mechanisms Of Cd4+T Tolerance To A Corneal Epithelial Neoantigen, Jeremias G Galletti, Kaitlin K Scholand, Jianming Shao, Eric P Fujisaki, Prashant Kumar, Elizaveta A Demianova, Elle Joy J San Juan, Laura Schaefer, Cintia S De Paiva

Faculty, Staff and Students Publications

Tissue-specific peripheral tolerance mechanisms are essential to prevent autoimmunity. The cornea is immune privileged, and anterior chamber-associated immune deviation (ACAID) governs its inner surface. However, the mechanisms governing corneal epithelial (outer surface) antigens remain unknown. Using an inducible, cornea-restricted neoantigen mouse model, we found that tolerance of corneal epithelial antigens is associated with antigen-specific regulatory T cell (Treg) induction. Although the cornea is both avascular and alymphatic, its epithelial antigens are still efficiently presented by ocular surface-derived antigen-presenting cells to T cells in draining lymph nodes under homeostatic conditions, leading to conventional antigen-specific Treg expansion without ocular pathology. This tolerance …

Healthcare Leaders’ Successful Strategies To Reduce Costs Due To Preventable Medical Errors, Brenda-Lee Persad

Walden Dissertations and Doctoral Studies

Preventable medical errors have the potential to cause patient harm, increase healthcare utilization, and create substantial financial costs for healthcare organizations. Healthcare leaders are concerned with preventable medical errors because they are a prime indicator of adverse effects on patient safety, organizational performance, and financial resources. Grounded in complex adaptive systems theory, the purpose of this qualitative pragmatic inquiry was to identify and explore successful strategies that healthcare leaders use to reduce the financial costs due to preventable medical errors. The participants were eight healthcare leaders in New York, who had at least 10 years of senior healthcare leadership experience, …

Strategies For Non-Profit Organizations To Archive In The Cloud, Latonya Edmond

Walden Dissertations and Doctoral Studies

Information Technology (IT) managers of nonprofit organizations are concerned about the loss of archival data, which often contains history and other valuable information they seek to preserve. Non-profit organizations face the risk of data loss due to a lack of strategies for migrating archival information to the cloud. Grounded in the diffusion of innovation theory, the purpose of this qualitative pragmatic inquiry was to explore the strategies for IT managers of nonprofit organizations to implement cloud-based archiving. The participants were 5 IT managers from nonprofit organizations in Maryland, Virginia, and Washington, D.C. Data were collected using semistructured interviews and publicly …

Human Norovirus Infection Does Not Induce Serotonin Secretion In Human Intestinal Organoids, Hephzibah Nwanosike, Vijayalakshmi B Ayyar, Michael J Bolt, Aaya Boussattach, Yi-Ting Shen, Sarah E Blutt, Mary K Estes, Robert L Atmar, Sasirekha Ramani

Faculty, Staff and Students Publications

Human noroviruses (HuNoVs) are a leading cause of acute gastroenteritis worldwide. The primary symptoms of HuNoV-associated disease are vomiting and diarrhea; yet the mechanisms underlying these symptoms are poorly understood. Neuroactive hormones such as serotonin (5-hydroxytryptamine; 5-HT) secreted by intestinal enteroendocrine cells (EECs) can activate vomiting centers in the brain and play a critical role in regulating emetic signaling. Serotonin release from infected EECs has been implicated in vomiting during other enteric infections. Recent studies have reported the detection of HuNoV RNA and antigen in EECs in jejunal biopsies from immunocompromised patients with chronic HuNoV infection and rhesus macaques. We …

Impact Of Nurse Residency Programs Compared To Direct Hire Models On Competence, Retention, And Job Satisfaction In New Graduate Nurses, Courtney Cole Hiscox

Walden Dissertations and Doctoral Studies

Background: The transition from student nurse to practicing registered nurse is a challenging period marked by role overload, emotional stress, and inconsistent preparation. In healthcare organizations, varied onboarding pathways create a critical practice gap that can compromise clinical confidence, lower job satisfaction, and trigger nurse turnover. Purpose & Methods: The purpose of this doctoral quality improvement project was to evaluate whether participation in a structured nurse residency program (NRP) improves transition-to-practice outcomes compared to direct-hire onboarding at a tertiary care center in West Tennessee. Utilizing a retrospective matched cohort design, de-identified data from new graduate nurses hired between August 2024 …

Effect Of Sterilisation Time On The Physicochemical Properties Of Palm Oil Produced In A Special Palm Oil Plant, Oseni Kehinde Owolarafe, T. A Folawiyo, Thomas Adedayo Ayorinde, Adekunle. Temidayo Atta, Adams. A Salami

Engineering and Technology Journal

Crude palm oil produced by small and medium scale palm oil mills is often of varying quality due to inadequate process control, particularly during sterilisation. The current research assessed the impact of sterilisation time on the efficiency and quality of crude palm oil extracted from the new Special Palm Oil (SPO) mill built at the Obafemi Awolowo University Teaching and Research Farm in Ile-Ife, Nigeria. Fresh fruit bunches were subjected to two sterilisation times: Sample A - 45 minutes and Sample B - 60 minutes, while maintaining a pressure of 5 bar. The parameters like oil yield, extraction percentage, free …

Mitigating Collapse Potential In Gypseous-Sand Through Nanoclay Integration: Comparative Oedometer Analysis Of Soils, Mustafa Jamal Abrahim, Mahmood R. Mahmood, Mohammed Shakir Mahmood

Engineering and Technology Journal

Collapsibility upon wetting is one of the major geotechnical problems associated with gypseous soils, primarily due to gypsum dissolution and the consequent loss of interparticle bonding, which may adversely affect the stability of structures and foundations. This study aims to evaluate the effectiveness of nanoclay in improving the collapse, compressibility, and rebound behavior of two gypseous sandy soils with different gypsum contents: G-29, containing 29% gypsum, and collected from Najaf Governorate, and G-55, containing 55% gypsum and collected from Tikrit Governorate. The behavior of both soils was evaluated using single oedometer tests (SOT), initially in the untreated condition to investigate …

Impacts Of Climate Variability On Infiltration And Groundwater Recharge In The Southeastern Coastal Region Of Côte D'Ivoire, Oulai Jean-Gautier Kpan, Assa Fabrice Yapi, Malan Ketcha Armand Kablan, Yeï Marie Solange Oga, Jean Biemi

Engineering and Technology Journal

This study assesses the impacts of climate variability on infiltration and groundwater recharge within the southeastern coastal corridor of Côte d'Ivoire, spanning from Abidjan to Aboisso. The methodology integrates the Pettitt test to detect rainfall stationarity breaks, followed by water balance modeling using the Thornthwaite and Tixeront–Berkaloff methods to quantify infiltration. The analysis relies on a multi-decadal meteorological dataset, including a 54-year rainfall series (1960–2014) and a 43-year temperature record (1971–2014), coupled with a 23-year historical groundwater level monitoring dataset (1982–2005) obtained from deep boreholes. precipitation fluctuations were correlated with piezometric level variations across 30 shallow wells and 9 deep …

Hardware-Isolated Thermodynamic Coprocessor For Appliance-Aware Multi-Zone Climate Control And Anticipatory Time-Of-Use Tariff Scheduling, Rohan Garg

Defensive Publications Series

This publication describes a climate control node (e.g., a smart thermostat) that includes a hardware-isolated thermodynamic coprocessor. In an example implementation, the coprocessor intercepts or otherwise receives power-related telemetry that appliances broadcast on a local low-power mesh network and converts that telemetry into anticipated heat loads for individual zones of a building. For instance, a radio baseband may capture mesh-network frames, a hardware filter may match application-layer cluster identifiers such as electrical power measurement and device energy management clusters, and matched payloads may be transferred by direct memory access into an isolated memory buffer that the coprocessor reads. In certain …

Technical Disclosure Specification: Eckesonium™ - Spec 173, Christopher L. Eckes

Defensive Publications Series

This technical specification details the synthesis, chemical composition, and quantum structural mechanics of Eckesonium™ (Ek), a standalone interstitial metastable high-entropy alloy (iMHEA) engineered for extreme isotropic ductility, universal solid-solution compatibility, and an infinite fatigue limit under cyclical mechanical deformation. Moving beyond traditional metallurgy paradigms that enforce an inverse trade-off between hardness and brittleness, Eckesonium™ leverages a finely tuned Stacking Fault Energy (SFE) boundary grid.

This triggers simultaneous Twinning-Induced Plasticity (TWIP) and Transformation-Induced Plasticity (TRIP) under macrovascular stress inputs. This specification registers the exact atomic configuration, thermodynamic derivation, and thermo-mechanical processing matrix into the public domain as defensive …

Divergent Geographies Of Disadvantage: Multidimensional Poverty And Teacher-Deployment Priority Across Ghana's 261 Districts, Bismark B. Fermah, Cai Lianyu

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Ghana relies on two district-level rankings of disadvantage to guide equity policy: a census-based multidimensional poverty index and a teacher-deployment priority list. Because the deployment flag conditions on classroom overcrowding, the inverse care law predicts the two should diverge, yet policy treats them as interchangeable. This study examined whether the two rankings identify the same districts. This descriptive ecological cross-sectional study linked the 2021 Census multidimensional poverty statistics to the 2026 Teachers for All: Ghana classification across all 261 districts and 16 regions, applying Welch's t test, two one-sided tests of equivalence against pre-specified margins of 10.0 and 4.8 percentage …

Illegal Migration In Nigeria: An In-Depth Study Of Encounters Within Nigeria, Mubarak Alabi, Adebayo Olalekan, Adam Isiaka, Abosede Onifade

African Journal of Criminology and Justice Studies

Migration is a crucial component of global population dynamics and encompasses various forms of labor, such as low-skilled labor, irregular migration, and asylum-seeking. This study examines illegal migration into Nigeria, illuminating the complex challenges faced by both migrants and the Nigerian Immigration Service (NIS). The surge in cross-border crimes linked to illegal immigration poses formidable obstacles to NIS, including issues related to border security, arms proliferation, and terrorism. The study employed a survey design, involving a diverse sample of 50 respondents, representing a cross-section of socio-demographic backgrounds. The outcome unravels the underlying motivations driving individuals towards illegal migration, identifies barriers …

An Exploration Of Psychosocial Determinants Of Cybercrime Intention Among Youths In Oyo State, Nigeria, Moromoke Nimota Raji, Musa Adeyemi Ogunsola, Jamiu Agbolade Ogunsola

African Journal of Criminology and Justice Studies

Cybercrime has become a pressing issue among adolescents and youths, particularly in Nigeria, where a growing number of young individuals engage in cyber-related offences. This study explores the relationship between key risk factors and the intention to commit cybercrime. Utilizing a descriptive correlational survey design, 300 students from six secondary schools in Ibarapa East were randomly selected as participants. Data collection was conducted using validated instruments, including the Cybercrime Intention Scale (α = 0.88), Levenson’s IPC scale  (α = 0.78), Materialistic Value Scale (α = 0.74), Parenting Style Scale (α = 0.77) and Peer Influence Scale …