Digital Commons Network^™

The Other In The Self: The Ontological Metaphoricity Of Language, Cristina Valencia Mazzanti, Melissa Freeman

Education and Child Study: Faculty Publications

Through text and illustrations, I (first author) theorize language as a being that becomes and revels in its plurality, illuminating the inherent and necessary aesthetic and multimodal dimensions of any struggle toward meaning. To do so, I start by foregrounding my own experiences with the diversity that characterizes language to portray the significance of studying its ontology and plurality. I then identify philosophical hermeneutics as a practical metatheory that centrally positions language as a medium for understanding. From a hermeneutic perspective, language manifests as a network of meaning that is constituted through an ontological metaphoricity that echoes a capacity to …

Twitter: More Than Tweets For Undergraduate Student Researchers, Nathan S. Reyna, Christin Pruett, Mike Morrison, Jennifer Fowler, Sumali Pandey, Lori Hensley

Research, Publications & Creative Work

A vital component of a CURE is feeling a sense of community. While our students often present to each other at the end of the semester, we have struggled with having them interact with a wider audience. A few students may present class results at a regional or national meeting; however, feasibility limits this opportunity to only a handful of students. Twitter has been used as a tool to disseminate scientific findings (1, 2). As a result of COVID-19, scientific societies have used Twitter to provide snapshots of research to be presented at their virtual meetings using “Twitter Posters” (Michael …

Biofilms On Plastic Litter: Community Composition And Activity And The Effects On Ecosystem Processes, Raul F. Lazcano

Master's Theses

The rapid increase of plastic production and disposal has resulted in plastic pollution becoming a global problem. In aquatic ecosystems, plastic litter is a substrate for biofilms, but little research has simultaneously assessed the effects of plastic litter on biofilm activity, community composition, and ecosystem processes. Our objectives were to: (1) measure biofilm activity and community composition on plastic litter relative to a natural surface in an urban river and (2) assess the impact of microplastic pollution on ecosystem metabolism and N2 flux in an oligotrophic lake. For objective (1) we incubated three common plastics with distinct physical and chemical …

The World Health Organization, The Trump Administration, American Public Opinion, And China: A Principal-Agent Problem, Megan Patrice Larson

Master's Theses

Why did the United States perceive the World Health Organization as ineffective during the COVID-19 pandemic? To answer this question, this research delves into current principal-agent model literature to reproduce mechanisms present by the WHO and the United States. Current research fails to explain the WHO's effectiveness. By borrowing from realist theory and political psychology and analyzing various declarations made by the United States, this analysis found preliminary evidence that the idea of WHO's ineffectiveness was primarily shaped by the Trump Administration and American public opinion. Moreover, because of the disinformation and misinformation spread by the Trump Administration, the WHO …

Dna Methylation Patterns Of Line-1 Elements Specific To Hc21p In Cancer Cells, Dametria Jetters

Master's Theses

Long Interspersed Nuclear Elements (LINEs) are retrotransposons. They function by making a cDNA copy, reverse-transcribing it into DNA and reinserting itself back into the genome; thereby, increasing its copy number. Sequencing of the human genome revealed that LINEs (L1) are underrepresented on the short arm of human chromosome 21 (HC21), but it is enriched in full-length copies. A number of previous studies have investigated the DNA methylation patterns of L1s in cancer cells, but these studies are typically done in euchromatic regions. The heterochromatic short arm of HC21 is primarily composed of heterochromatin. However these regions can be targeted for …

Unveiling Bacterial Hitchhikers In The Urobiome, Genevieve Baddoo

Master's Theses

Microbial communities of bacteria, viruses, and fungi form complex interactions in nature. However, our understanding of these communities is limited to those that can be cultured in the lab. Enhanced culture methods have enabled the isolation of numerous fastidious species from urinary tract, definitively proving that the urinary tract of asymptomatic individuals is not sterile. In working with these isolates, our group has observed several instances in which a “purified” isolate actually harbors more than one species. We refer to these additional members as bacterial hitchhikers, a term previously used to describe similar occurrences in soil communities. I hypothesized that …

Modeling The Impact Of Peer Mentorship To Support First-Year Student Well-Being, Sarah Broner

Master's Theses

The transition to college is characterized by instability in a variety of life domains, with some students experiencing sharp declines in well-being across the first year of college (Conley et al., 2014). Well-established in the literature is the link between this life transition and increased rates of mental illness, including depression, anxiety, stress, and relationship problems (Auerbach et al., 2018). The adjustment to higher education can be particularly difficult for underserved students (Carter et al., 2013; Kalsner & Pistole, 2003), who may not have access to the same types of knowledge, resources, and privileges as their White counterparts on campus. …

Hispanic Teachers And Leaders In Catholic Schools: Special Issue Introduction, Melodie Wyttenbach, Hosffman Ospino

Journal of Catholic Education

Introduction to the Special Issue

The Impact Of Perceived Discrimination And Stigma Consciousness On Connectedness, Trust, And Satisfaction In Healthcare Domains During The Covid-19 Pandemic, Devon Richardson

Master's Theses

This study will assess the relations between perceived experiences of discrimination within healthcare settings and connectedness, trust, and satisfaction with services in healthcare domains among African Americans. It will also examine if the Covid-19 pandemic has exacerbated this relationship. I predict that African Americans in the COVID-19 discrimination condition (versus the control condition) will report lower connectedness and trust with healthcare workers and lower satisfaction with healthcare services. I also predict that stigma consciousness will moderate this effect. For African Americans reporting lower levels of stigma consciousness, I expect there will be a negative relation between perceiving discrimination and connectedness, …

Psychological Symptoms, Visceral Pain Sensitivity, And Observations Of Parent Pain Behavior Are Related To Somatic Symptoms In Premenarchal Adolescents, Genevieve Roth

Master's Theses

Somatic symptoms are a risk factor for the development of chronic pelvic pain in women. The present study characterized somatic symptoms and their relations with psychological, pain sensitivity, and parental factors in a community sample of premenarchal adolescents, which marks an initial step in advancing the identification of potential modifiable factors related to menstrual pain and chronic pain development. Pain sensitivity (visceral and bodily factors) and psychological symptoms (anxiety and stress) were predicted to be related to somatic symptoms (e.g, widespread bodily discomfort) in premenarchal adolescents. Additionally, adolescents’ observation of parent pain behavior was expected to be specifically associated with …

Book Review: Teacher Diversity And Student Success: Why Racial Representation Matters In The Classroom, Aubrey Scheopner Torres

Journal of Catholic Education

No abstract is published with book reviews

Rethinking The Hispanic Teacher Shortage: Dual Language Schools As Identity-Affirming Organizations, Elena Sada, Katie Ward

Journal of Catholic Education

Research has established the connection between the academic success of culturally and linguistically diverse students, and their schools’ ability to recruit and retain teachers that reflect such diversity (Shirrell et al., 2019). Studies have also highlighted the criticality of the students’ home language use as a way to enhance academic growth and develop their sociocultural competence and well-being (Feinauer & Howard, 2014). There is no research, however, addressing the differences between the experiences of Hispanic teachers in bilingual Catholic education compared to those in monolingual English Catholic education. This article highlights the differences captured by a recent study, and discusses …

A Tale Of Five Case Studies: Reflections On Piloting A Case-Based, Problem-Based Learning Curriculum In English Composition, Katie Strand, Rachel Wishkoski, Alex J. Sundt, Deanna Allred

Library Faculty & Staff Publications

Part of a volume about storytelling in academic library contexts, this chapter reflects on the use of case studies in a sequenced information literacy curriculum in ENGL 2010 (Intermediate Writing: Research Writing in a Persuasive Mode). In highly interactive sessions across the semester, students collaboratively researched a case study topic and co-created artifacts that reflected their shared journey as researchers. The chapter is organized into the following sections, consistent with the other chapters in the book: classroom vignette, storytelling goal, audience, delivery, theory, cultural considerations, and practical examples. Readers will learn about things to consider when using case-based problem-based learning …

Utah State University Graduate & Professional Student Survey: Report Of Findings, Merrill-Cazier Library, Ithaka S+R Survey

Library Faculty & Staff Publications

The Utah State University implementation of the Ithaka S+R Graduate & Professional Student Survey was launched on November 8^th, 2021, and was closed to new responses on December 13^th, 2021, with a total of 365 complete responses. The questionnaire covers topics in several key areas including: students’ use of assigned course materials; practices and preferences for curricular and non-curricular information discovery; the role of the library; use of library space; objectives in obtaining an advanced degree; and understanding of and interest in conducting or contributing to original research. The following report provides a high-level overview of …

The Sin Of Racism, Ray Almanza

LMU Theses and Dissertations

This project examines the history of racism in relation to the Catholic Church. This history amounts to an indictment of the Roman Catholic Church not only as a neutral party in the historical emergence of white supremacy, but a directly linked cause of racism. First, it describes how racism emerged in its modern manifestation in three major dimensions which include the geopolitical, economic, and social. Then, it centers on two general forms of analysis, a cultural analysis, and a philosophical analysis. Drawing on insights from Liberation Theology, various themes are highlighted as they apply to the discussion of race in …

Who Gets To Know? Combating Colonial Epistemic Oppression, Timothy J. Cotter

Senior Independent Study Theses

This Independent Study thesis is divided into five chapters. In the introduction, I explain the focus of the paper. In the second chapter, “Landscapes of Epistemic Injustice,” I clarify the concept of epistemic injustice by breaking it down into hermeneutical injustice and testimonial injustice. I argue that we have obligations to each other as knowers and producers of knowledge, and the content of these obligations within a given situation depends upon the social position of both the speaker and the audience or audiences. In the third chapter, “Epistemic Oppression and Colonialism,” I contend that Western colonial projects frequently enact third-order …

Affirmed Or Delegated? Finding Inherent Tribal Civil Power To Issue Protection Orders Against All Persons In Light Of Spurr V. Pope, Kelly Gaines Stoner, Cherokee Ancestry, Lauren Van Schilfgaarde, Cochiti Pueblo

Tribal Law Journal

Federal courts have wreaked havoc on tribal jurisdiction by injecting incertitude over their most basic authority, including the authority to issue and enforce civil protection orders. This jurisdictional incertitude causes not just legal disruption, but also further compromises the safety of Native people who are disproportionately victimized, especially by gender-based forms of violence. While Congress has been slow to remedy the onslaught of judicial limitations on tribal jurisdiction, Congress has at least remedied tribal authority to issue and enforce protection orders in 18 U.S.C. § 2265(e). However, even in this remedy, jurisdictional incertitude remains.

Highlights From The 7th Oncological Pathology Conference 'Pathological Anatomy In The Context Of The National Cancer Law: An Overview Of The Latin American Experience', 15, 22 And 23 July 2022, Trujillo, Peru, Caddie Laberiano-Fernández, Joan Moreno Luján, Bruno De Carvalho Dornelas, Magali Franco Benites, Patricia Gutiérrez Quispe, Valeria Aguilar Vásquez, Andric Guerrero Espinoza, Elsa Guerra Guerra, Gabriela Gil-Arroyo Álvarez, Juan Astigueta-Pérez, Maria Teresa Garcia De Dávila, Sandro Casavilca Zambrano, Tatiana Vidaurre Rojas, Alejandro Mariños, Emmanuel S González, Rossana Lazcano, Ricardo R Lastra, Isabel Alvarado-Cabrero, Henry Guerra Miller, Ricardo H Bardales, Milagros Abad-Licham

Faculty, Staff and Student Publications

The seventh session of the Oncological Pathology Conference (JoPaO) entitled 'Pathological Anatomy in the context of the National Cancer Law: An overview of the Latin American experience', was held virtually on July 15, 22 and 23. Peru was the headquarters for this event, where 17 national and international professors of high academic standing participated. They interacted in a multidisciplinary context through talks with national panellists and the general public. The recent promulgation of the 'National Cancer Law' fosters the development of discussion forums to analyse the national realities and uphold continuous learning about experiences in other Latin American countries with …

Contemporary Evidence On Colorectal Liver Metastases Ablation: Toward A Paradigm Shift In Locoregional Treatment, Yuan-Mao Lin, Reto Bale, Kristy K Brock, Bruno C Odisio

Faculty, Staff and Student Publications

Image-guided percutaneous ablation techniques represent an attractive local therapy for the treatment of colorectal liver metastases (CLM) given its low risk of severe complications, which allows for early initiation of adjuvant therapies and spare functional liver parenchyma, allowing repeated treatments at the time of recurrence. However, ablation does not consistently achieve similar oncological outcomes to surgery, with the latter being currently considered the first-line local treatment modality in international guidelines. Recent application of computer-assisted ablation planning, guidance, and intra-procedural response assessment has improved percutaneous ablation outcomes. In addition, the evolving understanding of tumor molecular profiling has brought to light several …

Serglycin Is Involved In Tgf-Β Induced Epithelial-Mesenchymal Transition And Is Highly Expressed By Immune Cells In Breast Cancer Tissue, Marta Tellez-Gabriel, Xavier Tekpli, Trine M Reine, Beate Hegge, Stephanie R Nielsen, Meng Chen, Line Moi, Lisa Svartdal Normann, Lill-Tove R Busund, George A Calin, Gunhild M Mælandsmo, Maria Perander, Achilleas D Theocharis, Svein O Kolset, Erik Knutsen

Faculty, Staff and Student Publications

Serglycin is a proteoglycan highly expressed by immune cells, in which its functions are linked to storage, secretion, transport, and protection of chemokines, proteases, histamine, growth factors, and other bioactive molecules. In recent years, it has been demonstrated that serglycin is also expressed by several other cell types, such as endothelial cells, muscle cells, and multiple types of cancer cells. Here, we show that serglycin expression is upregulated in transforming growth factor beta (TGF-β) induced epithelial-mesenchymal transition (EMT). Functional studies provide evidence that serglycin plays an important role in the regulation of the transition between the epithelial and mesenchymal phenotypes, …

Pathogenic Tau Accelerates Aging-Associated Activation Of Transposable Elements In The Mouse Central Nervous System, Paulino Ramirez, Gabrielle Zuniga, Wenyan Sun, Adrian Beckmann, Elizabeth Ochoa, Sarah L Devos, Bradley Hyman, Gabriel Chiu, Ethan R Roy, Wei Cao, Miranda Orr, Virginie Buggia-Prevot, William J Ray, Bess Frost

Faculty, Staff and Student Publications

Transposable elements comprise almost half of the mammalian genome. A growing body of evidence suggests that transposable element dysregulation accompanies brain aging and neurodegenerative disorders, and that transposable element activation is neurotoxic. Recent studies have identified links between pathogenic forms of tau, a protein that accumulates in Alzheimer's disease and related "tauopathies," and transposable element-induced neurotoxicity. Starting with transcriptomic analyses, we find that age- and tau-induced transposable element activation occurs in the mouse brain. Among transposable elements that are activated at the RNA level in the context of brain aging and tauopathy, we find that the endogenous retrovirus (ERV) class …

Research Career Intentions Among Non-Native English-Speaking Graduate And Postdoctoral Trainees In Stem-Results From Cross-Sectional And Longitudinal Studies, Hwa Young Lee, Shine Chang, Cheryl B Anderson, Erin K Dahlstrom, Carrie Cameron

Faculty, Staff and Student Publications

International graduate trainees, many of whom are non-native English-speaking (L2) trainees, comprise more than half of graduate-level trainees in STEM, but little is known regarding factors that influence their career intentions, especially those that foster their growth as scientists to achieve their full potential in research. Thus, the purpose of our studies was to examine the relationship between L2 status and contextual factors that help shape the learning experiences and plans for research-focused careers. Study 1 collected cross-sectional survey data from doctoral and postdoctoral trainees (N=510) from research institutes in the Texas Medical Center in Houston. We examined which factors …

Transcriptomic-Assisted Immune And Neoantigen Profiling In Premalignancy, Kyle Chang, Florencia Mcallister, Eduardo Vilar

Faculty, Staff and Student Publications

Immune-based cancer therapies such as checkpoint inhibitors (CPI) and vaccines have been increasingly studied across different cancer types. Response to such therapies depends on a number of factors such as mutational burden, neoantigen load, presence of tumor infiltrating lymphocytes, among others. Next-generation sequencing (NGS) technologies are particularly attractive to interrogate the immune response compared to traditional assays such as qRT-PCR and immunohistochemistry (IHC) because they enable the discovery of neoantigens and simultaneous profiling of immune infiltration using gene expression on a large scale. Current approaches in immune profiling utilizes whole-exome sequencing (WES) for human leukocyte allele (HLA) typing and neoantigen …

Cancer Prevention Behaviors In Workers Of A Referral Cancer Center In Mexico City: A Pilot Study On Early Detection Awareness For Cancer, Nancy Reynoso-Noverón, Shine Chang, Luis Alonso Herrera-Montalvo, Abelardo Meneses-García

Faculty, Staff and Student Publications

Background: Prevention strategies for cancer are necessary. Health workers who often serve as role models bear responsibility for prevention counseling and programs. However, whether their habits and behaviors reflect prevention goals are unknown. We describe the prevalence of cancer risk factors and prevention behaviors in health workers of a referral cancer center in Mexico City.

Methods: Cross-sectional study in which workers of the National Cancer Institute were invited to participate in a prevention program, risk factor survey, and nutrition, psychological, and genetic counseling were included. The likelihood of cancer was calculated based on the presence of risk factors. Factors associated …

Genetic Studies On Mammalian Dna Methyltransferases, Jiameng Dan, Taiping Chen

Faculty, Staff and Student Publications

Cytosine methylation at the C5-position-generating 5-methylcytosine (5mC)-is a DNA modification found in many eukaryotic organisms, including fungi, plants, invertebrates, and vertebrates, albeit its levels vary greatly in different organisms. In mammals, cytosine methylation occurs predominantly in the context of CpG dinucleotides, with the majority (60-80%) of CpG sites in their genomes being methylated. DNA methylation plays crucial roles in the regulation of chromatin structure and gene expression and is essential for mammalian development. Aberrant changes in DNA methylation and genetic alterations in enzymes and regulators involved in DNA methylation are associated with various human diseases, including cancer and developmental disorders. …

Electroacupuncture Ameliorates Inflammatory Response Induced By Retinal Ischemia-Reperfusion Injury And Protects The Retina Through The Dor-Bdnf/Trkb Pathway, Runjie Guo, Yongjie Zhang, Yue Geng, Ping Chen, Tiantian Fu, Yong Xia, Ren Zhang, Yuan Zhu, Jingling Jin, Nange Jin, Hong Xu, Xuesong Tian

Faculty, Staff and Student Publications

Objectives: Retinal ischemia-reperfusion injury (RIRI) is the common pathological basis of many ophthalmic diseases in the later stages, and inflammation is the primary damage mechanism of RIRI. Our study aimed to assess whether electroacupuncture (EA) has a protective effect against RIRI and to elucidate its related mechanisms.

Methods: A high-intraocular pressure (HIOP) model was used to simulate RIRI in Wistar rats. EA was applied to the EA1 group [Jingming (BL1) + Shuigou (GV26)] and the EA2 group [Jingming (BL1) + Hegu (LI4)] respectively for 30 min starting immediately after the onset of reperfusion and repeated (30 min/time) at 12 h …

A Multicenter Study Of Icu Resource Utilization In Pediatric, Adolescent And Young Adult Patients Post Car-T Therapy, Dristhi Ragoonanan, Saleh Bhar, Gopi Mohan, Fernando Beltramo, Sajad J Khazal, Caitlin Hurley, Clark Andersen, Steven Margossian, Sattva S Neelapu, Elizabeth Shpall, Cristina Gutierrez, Priti Tewari, Basirat Shoberu, Aimee Talleur, David Mccall, Cesar Nunez, Branko Cuglievan, Francesco Paolo Tambaro, Demetrios Petropoulos, Hisham Abdel-Azim, Kris M Mahadeo

Faculty, Staff and Student Publications

Tisagenlecleucel is associated with remarkable outcomes in treating patients up to the age of 25 years with refractory B-cell acute lymphoblastic leukemia (ALL). Yet, due to unique and potentially life-threatening complications, access remains limited to higher-resource and certified centers. Reports of inequity and related disparities in care are emerging. In this multicenter study of ALL patients admitted for anti-leukemia therapy, who required pediatric intensive care (ICU) support (n = 205), patients receiving tisagenlecleucel (n = 39) were compared to those receiving conventional chemotherapy (n = 166). The median time to ICU transfer was 6 (0-43) versus 1 (0-116) days, respectively …

Immune Checkpoint Inhibitor-Related Gastrointestinal Toxicity In Patients With Malignancy Involving The Luminal Gastrointestinal Tract And Its Impact On Cancer Outcomes, Kevin Yu, Antony Mathew, Fiyinfoluwa Abraham, Rajan Amin, Miho Kono, Michael Overman, Dan Zhao, Anam Khan, Muhammad A Khan, Anusha S Thomas, Yinghong Wang

Faculty, Staff and Student Publications

Background: Immune checkpoint inhibitors (ICI) are known to cause immune-related adverse events (irAE) with the gastrointestinal (GI) tract among the most affected. Our knowledge of GI irAE in patients with luminal GI malignancies is poor. We aimed to characterize the incidence, clinical features, treatment, and outcomes of these GI irAEs.

Methods: This was a retrospective study of patients with malignancies involving the luminal GI tract and GI irAEs at MD Anderson Cancer Center from January 2010 to June 2020. Clinical data were collected and analyzed.

Results: Eighteen patients with luminal GI tract malignancies treated with ICIs had evidence of GI …

Association Of Adenotonsillar Disease And Adenotonsillectomy With The Development Of Vitiligo: A Nationwide Population-Based Cohort Study, Jong Seung Kim, Min Gyu Lee, Sang-Kyung Lee, Sang-Woo Yeom, Min-Gu Kang, Jong Hwan Lee, Il-Jae Lee, Jin Park, Seok-Kweon Yun, Kyung-Hwa Nam

Faculty, Staff and Student Publications

BACKGROUND: Vitiligo is a common acquired skin depigmentation disorder and is associated with various other autoimmune diseases which include thyroid disease and rheumatoid arthritis. Similarly, adenotonsillar disease (ATD) may induce inflammatory or autoimmune diseases in other organs which include the skin. However, the influence of ATD on the development of vitiligo has not been studied.

OBJECTIVES: To determine the association between ATD and adenotonsillectomy, and the development of vitiligo.

DESIGN AND METHODS: Using data from the National Health Insurance Service database, patients diagnosed with ATD between 2008 and 2010 were included in the study. We performed two rounds of 1:1 …

Exploiting Induced Vulnerability To Overcome Parpi Resistance And Clonal Heterogeneity In Brca Mutant Triple-Negative Inflammatory Breast Cancer, David J H Shih, Mei-Kuang Chen, Jun Yin, Daniel J Mcgrail, Hui Dai, Rongbin Wei, Jing Zhang, Wenjin Jim Zheng, Kim-Anh Do, Liuqing Yang, Mien-Chie Hung, Shiaw-Yih Lin

Faculty, Staff and Student Publications

Acquired resistance and clonal heterogeneity are critical challenges in cancer treatment, and the lack of effective computational tools hampers the discovery of new treatments to overcome resistance. Using high-throughput transcriptomic databases of compound perturbation profiles, we have developed a bioinformatic strategy for identifying candidate drugs to overcome resistance with combinatorial therapy. We devised this strategy during an investigation into the acquired resistance against PARP inhibitors (PARPi) in a triple-negative inflammatory breast cancer cell line. In this study, we derived multiple PARPi-resistant clones and characterized their transcriptomic adaptations compared to the parental clone. The transcriptomes of the resistant clones showed substantial …