Digital Commons Network^™

Epithelial Immunomodulation By Aerosolized Toll-Like Receptor Agonists Prevents Allergic Inflammation In Airway Mucosa In Mice, David L Goldblatt, Gabriella Valverde Ha, Shradha Wali, Vikram V Kulkarni, Michael K Longmire, Ana M Jaramillo, Rosha P Chittuluru, Adrienne Fouts, Margarita Martinez-Moczygemba, Jonathan T Lei, David P Huston, Michael J Tuvim, Burton F Dickey, Scott E Evans

Faculty, Staff and Student Publications

Allergic asthma is a chronic inflammatory respiratory disease associated with eosinophilic infiltration, increased mucus production, airway hyperresponsiveness, and airway remodeling. Epidemiologic data reveal that the prevalence of allergic sensitization and associated diseases has increased in the twentieth century. This has been hypothesized to be partly due to reduced contact with microbial organisms (the hygiene hypothesis) in industrialized society. Airway epithelial cells, once considered a static physical barrier between the body and the external world, are now widely recognized as immunologically active cells that can initiate, maintain, and restrain inflammatory responses, such as those that mediate allergic disease. Airway epithelial cells …

Comparison Of Three Exercise Interventions With And Without Gemcitabine Treatment On Pancreatic Tumor Growth In Mice: No Impact On Tumor Infiltrating Lymphocytes, Priti Gupta, Charles F Hodgman, Claudia Alvarez-Florez, Keri L Schadler, Melissa M Markofski, Daniel P O'Connor, Emily C Lavoy

Faculty, Staff and Student Publications

Exercise has been shown to slow pancreatic tumor growth, but whether exercise interventions of differing volume or intensity yield differential effects on tumor outcomes is unknown. In this study, we compared three exercise training interventions implemented with and without chemotherapy on pancreatic tumor growth in mice. Methods: Male C57BL/6 mice (6-8 weeks old) were subcutaneously inoculated with pancreatic ductal adenocarcinoma tumor cells (PDAC 4662). Upon tumor detection, mice received gemcitabine 15 mg/kg intraperitoneally 3 days/week and were assigned to exercise: high volume continuous exercise (HVCE), low volume continuous exercise (LVCE), high intensity interval training (HIIT), or sedentary (SED). HVCE ran …

B Cells Are Required To Generate Optimal Anti-Melanoma Immunity In Response To Checkpoint Blockade, Shubhra Singh, Jason Roszik, Neeraj Saini, Vipul Kumar Singh, Karishma Bavisi, Zhiqiang Wang, Long T Vien, Zixi Yang, Suprateek Kundu, Richard E Davis, Laura Bover, Adi Diab, Sattva S Neelapu, Willem W Overwijk, Kunal Rai, Manisha Singh

Faculty, Staff and Student Publications

Immunotherapies such as checkpoint blockade therapies are known to enhance anti-melanoma CD8+ T cell immunity, but only a fraction of patients treated with these therapies achieve durable immune response and disease control. It may be that CD8+ T cells need help from other immune cells to generate effective and long-lasting anti-tumor immunity or that CD8+ T cells alone are insufficient for complete tumor regression and cure. Melanoma contains significant numbers of B cells; however, the role of B cells in anti-melanoma immunity is controversial. In this study, B16 melanoma mouse models were used to determine the role of B cells …

Automated Segmentation Of Colorectal Liver Metastasis And Liver Ablation On Contrast-Enhanced Ct Images, Brian M Anderson, Bastien Rigaud, Yuan-Mao Lin, A Kyle Jones, Hynseon Christine Kang, Bruno C Odisio, Kristy K Brock

Faculty, Staff and Student Publications

Objectives: Colorectal cancer (CRC), the third most common cancer in the USA, is a leading cause of cancer-related death worldwide. Up to 60% of patients develop liver metastasis (CRLM). Treatments like radiation and ablation therapies require disease segmentation for planning and therapy delivery. For ablation, ablation-zone segmentation is required to evaluate disease coverage. We hypothesize that fully convolutional (FC) neural networks, trained using novel methods, will provide rapid and accurate identification and segmentation of CRLM and ablation zones.

Methods: Four FC model styles were investigated: Standard 3D-UNet, Residual 3D-UNet, Dense 3D-UNet, and Hybrid-WNet. Models were trained on 92 patients from …

The Other Legacy Of Qasim Amin: The View From 1908, Hoda Yousef

Faculty Publications

No abstract provided.

The Religious Communication Approach And Political Behavior, Paul Djupe, Jacob R. Neiheisel

Faculty Publications

No abstract provided.

Book Review: Transforming Print: Collection Development And Management For Our Connected Future, Debra Andreadis

Faculty Publications

No abstract provided.

Divine Attribution? The Interaction Of Religious And Secular Beliefs On Climate Change Attitudes, Paul Djupe, Ryan P. Burge

Faculty Publications

No abstract provided.

Effects Of Co-Incubation Of Lps-Stimulated Raw 264.7 Macrophages On Leptin Production By 3t3-L1 Adipocytes: A Method For Co-Incubating Distinct Adipose Tissue Cell Lines, Cristina Caldari, Jordan Beck

Faculty Publications

No abstract provided.

Both Consumptive And Non-Consumptive Effects Of Predators Impact Mosquito Populations And Have Implications For Disease Transmission, Marie C. Russell, Catherine M. Herzog, Zachary Gajewski, Chloe Ramsay, Andy Mccall

Faculty Publications

No abstract provided.

Toward Liquid Cell Quantum Sensing: Ytterbium Complexes With Ultra-Narrow Absorption, Ashley J. Shin, Changling Zhao, Yi Shen, Claire E. Dickerson, Timothy Luke Atallah

Faculty Publications

No abstract provided.

Local Biodiversity Change Reflects Interactions Among Changing Abundance, Evenness, And Richness, Shane A. Blowes, Gergana N. Daskalova, Maria Dornelas, Thore Engel, Nicholas J. Gotelli, Anne E. Magurran, Ines S. Martins, Brian Mcgill, Daniel J. Mcglinn, Alban Sagouis, Hideyasu Shimadzu, Sarah R. Supp, Jonathan M. Chase

Faculty Publications

No abstract provided.

“You Don’T Belong In Nashville!”: Politics, Country Music, And The Reception Of Robert Altman’S Nashville, Dan Blim

Faculty Publications

Robert Altman’s film Nashville (1975) generated a prodigious amount of press commentary following its release. Early on, critics praised the film, but a disappointing box office led many to assume a split between big-city liberal audiences and small-town conservative audiences. Subsequent press coverage connected this divide to both the film’s politics and its use and portrayal of country music, as political pundits, music critics, country music stars, and general audiences weighed in. This essay situates the reception of the film within a shifting country music industry, which was growing increasingly aligned with the Republican Party and increasingly suspicious of new …

Growth In Snapping Turtle, Chelydra Serpentina (Testudines: Chelydridae) In Northern Indiana, John B. Iverson, Geoffrey R. Smith, Jessica E. Rettig

Faculty Publications

No abstract provided.

Exploring The Sexual Literacies Of Denison University Students, Ellie Gutmann

Student Scholarship

No abstract provided.

Friendship In College Students: Examining Changes In Time Perspective And Emotional Closeness, Blake H. Glatley

Student Scholarship

No abstract provided.

Meet The Staff

The Synapse: Intercollegiate science magazine

No abstract provided.

Left On Red: The Chemistry Of Color, Rebecca Fenselau, Kayla Bertholf

The Synapse: Intercollegiate science magazine

No abstract provided.

How Machine Learning Will Change Our World: How Machine Learning Can Make Life Easier - And A Bit More Complicated, Sakin Kirti

The Synapse: Intercollegiate science magazine

No abstract provided.

Monkey See, Humans Too: Understanding The Link Between Sight And Smell In Five Primate Species, Paul Kamitsuka, Evan Swanson

The Synapse: Intercollegiate science magazine

No abstract provided.

Eczema And Mental Health: The Silent Struggle Of Skin Disorders, Bhavana Huliyar

The Synapse: Intercollegiate science magazine

No abstract provided.

The Acoustics Of Concert Halls: Where Science, Music, & Visual Arts Meet, Norah Han

The Synapse: Intercollegiate science magazine

No abstract provided.

Emulsifiers: The Hidden Ingredients Holding Our Food Together, Joey O'Donnell

The Synapse: Intercollegiate science magazine

No abstract provided.

Earth's Other Lung: Phytoplankton, Sarah Barney

The Synapse: Intercollegiate science magazine

No abstract provided.

What Your Ears "Say" About You: Otoacoustic Emissions, Fay Levin

The Synapse: Intercollegiate science magazine

No abstract provided.

Microplastics In Coral Reef Skeletons: A Threat To Coastal Ecosystems And A Reservoir For Pollutants, Isabelle Small

The Synapse: Intercollegiate science magazine

No abstract provided.

The Food Dye Is Cast: What They Are, Why We Need Them, And If They Are Killing Us, Joey O'Donnel

The Synapse: Intercollegiate science magazine

No abstract provided.

Cerebral Palsy: Understanding The Disease, My Trinh

The Synapse: Intercollegiate science magazine

No abstract provided.

The Tale Of George Wright, Caroline Ward

The Synapse: Intercollegiate science magazine

No abstract provided.

Untitled (Illustration), Isabel Giammusso

The Synapse: Intercollegiate science magazine

No abstract provided.