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Effects Of Different Scar Types On Flap Viability In A Skin Flap Model: An Experimental Study, Ceyhun Uzun, Can İlker Demi̇r, Emrah Kağan Yaşar, Mehdi̇ Asadov, Murat Şahi̇n Alagöz, Esra Ci̇vri̇z, Çi̇ğdem Vural Jan 2022

Effects Of Different Scar Types On Flap Viability In A Skin Flap Model: An Experimental Study, Ceyhun Uzun, Can İlker Demi̇r, Emrah Kağan Yaşar, Mehdi̇ Asadov, Murat Şahi̇n Alagöz, Esra Ci̇vri̇z, Çi̇ğdem Vural

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study was to investigate the use of tissues with multiple traumas, scarred pedicles, and medial scarring as a flap. Materials and methods: Forty-eight rats were randomly divided into four equal groups. The modified McFarlane flap was chosen as the flap model. In Group 1 (control), a dorsal skin flap was elevated and then sutured back into original position. In the other groups, a two-phase procedure was used. In Group 2 (pedicle incision), scar tissue was created with a skin incision at the prospective pedicle site of the flap and then sutured to its original site. …

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Highlights In The Association Of Fragmented Qrs With Myocardial Fibrosis, Mehmet Eyüboğlu Jan 2022

Highlights In The Association Of Fragmented Qrs With Myocardial Fibrosis, Mehmet Eyüboğlu

Turkish Journal of Medical Sciences

No abstract provided.

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Fragmented Qrs Formation In Nonhypertensive Acromegaly Patients, Muhammet Dural, Göknur Yorulmaz, Kadi̇r Uğur Mert, Selda Murat Jan 2022

Fragmented Qrs Formation In Nonhypertensive Acromegaly Patients, Muhammet Dural, Göknur Yorulmaz, Kadi̇r Uğur Mert, Selda Murat

Turkish Journal of Medical Sciences

No abstract provided.

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Cover And Contents Jan 2022

Cover And Contents

Turkish Journal of Medical Sciences

No abstract provided.

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Circulating Mir-200c And Mir-33a May Be Used As Biomarkers For Predicting High Fructose Corn Syrup-Induced Fatty Liver And Vitamin D Supplementation-Related Liver Changes, Alpaslan Tanoğlu, Eylem Çağiltay, Esra Güzel Tanoğlu, Ayli̇n Gökhan, Cansin Şi̇ri̇n, Türker Çavuşoğlu, Recep Soner Yeşi̇lbaş Jan 2022

Circulating Mir-200c And Mir-33a May Be Used As Biomarkers For Predicting High Fructose Corn Syrup-Induced Fatty Liver And Vitamin D Supplementation-Related Liver Changes, Alpaslan Tanoğlu, Eylem Çağiltay, Esra Güzel Tanoğlu, Ayli̇n Gökhan, Cansin Şi̇ri̇n, Türker Çavuşoğlu, Recep Soner Yeşi̇lbaş

Turkish Journal of Medical Sciences

Background/aim: Nonalcoholic fatty liver is one of the most common forms of liver disease and role of microRNAs (miRNAs) on this illness is currently unclear. It was aimed to evaluate the predictive role of circulating miR-33a and mir-200c on high fructose corn syrup (HFCS)-induced fatty liver and vitamin D3 supplementation-related hepatic changes. Materials and methods: Twenty-four rats were randomized into three groups: sham (n = 8), experimental fatty liver group (n = 8), and fatty liver + vitamin D3 supplementation group (n = 8). In the treatment group, 10 µg/kg/week of vitamin D3 was given by orogastric tube weekly for …

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Frequency Of Alpha-1 Antitrypsin Deficiency And Unexpected Results In Copd Patients In Turkey; Rare Variants Are Common, Mustafa Çörtük, Bariş Demi̇rkol, Meli̇h Akay Arslan, Umut İlhan, Yunus Emre Kalkan, Demet Turan, Şule Gül, Hali̇t Çinarka, Kürşad Nuri̇ Baydi̇li̇, Erdoğan Çeti̇nkaya Jan 2022

Frequency Of Alpha-1 Antitrypsin Deficiency And Unexpected Results In Copd Patients In Turkey; Rare Variants Are Common, Mustafa Çörtük, Bariş Demi̇rkol, Meli̇h Akay Arslan, Umut İlhan, Yunus Emre Kalkan, Demet Turan, Şule Gül, Hali̇t Çinarka, Kürşad Nuri̇ Baydi̇li̇, Erdoğan Çeti̇nkaya

Turkish Journal of Medical Sciences

Background/aim: Alpha-1 antitrypsin (?1-AT) is a protease inhibitor that is largely released from liver cells. It inhibits neutrophil elastase and its deficiency increases the risk of developing chronic obstructive pulmonary disease (COPD). The frequency of ?1-AT deficiency has been reported with different prevalence rates in different parts of the world. The most common ?1-AT variant causing ?1-AT deficiency is the Pi*Z allele. In this study, we aimed to determine the frequency of the ?1-AT genotypic variant in COPD patients in our country. Materials and methods: In this study, 196 consecutive COPD patients admitted to our clinic were included. In addition …

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Comparison Of Anakinra And Tocilizumab In Management Of Severe Covid-19: A Retrospective Cohort Study, Orhan Küçükşahi̇n, Abdulsamet Erden, Özlem Karakaş, Serdar Can Güven, Berkan Armağan, Enes Seyda Şahi̇ner, Osman İnan, Ali̇ Can Kurti̇pek, Emi̇n Gemci̇oğlu, Selma Karaahmetoğlu, Sema Turan, Seval İzdeş, Deni̇z Erdem, Adalet Aypak, Müge Ayhan Jan 2022

Comparison Of Anakinra And Tocilizumab In Management Of Severe Covid-19: A Retrospective Cohort Study, Orhan Küçükşahi̇n, Abdulsamet Erden, Özlem Karakaş, Serdar Can Güven, Berkan Armağan, Enes Seyda Şahi̇ner, Osman İnan, Ali̇ Can Kurti̇pek, Emi̇n Gemci̇oğlu, Selma Karaahmetoğlu, Sema Turan, Seval İzdeş, Deni̇z Erdem, Adalet Aypak, Müge Ayhan

Turkish Journal of Medical Sciences

Background/aim: Studies regarding effectiveness of anakinra and tocilizumab treatments in coronavirus disease 2019 (COVID-19) have contradictory results. Furthermore, there is scarce comparative data regarding superiority of any agent. To further elucidate any superiority between these two agents, we retrospectively investigated and compared outcomes in hospitalized COVID-19 patients of our inpatient cohort who received anakinra or tocilizumab. Materials and methods: This study was designed as a single-center, retrospective, cross-sectional cohort study. Hospitalized patients with confirmed diagnosis of COVID-19 who had Brescia-COVID respiratory severity scale score ?3 and hyperinflammation (defined as elevation of C reactive protein ?50 g/L or ferritin ?700 ng/mL) …

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Magnetic Resonance Imaging Findings In Covid-19-Related Anosmia, Hüseyi̇n Çeti̇n, Ayşe Şule Ateş, Ogün Taydaş, Bahri̇ Elmas, Ertuğrul Güçlü Jan 2022

Magnetic Resonance Imaging Findings In Covid-19-Related Anosmia, Hüseyi̇n Çeti̇n, Ayşe Şule Ateş, Ogün Taydaş, Bahri̇ Elmas, Ertuğrul Güçlü

Turkish Journal of Medical Sciences

Background/aim: The coronavirus disease 2019 (COVID-19) mostly manifests with fever, shortness of breath, and cough, has also been found to cause some neurological symptoms, such as anosmia and ageusia. The aim of the study was to present the magnetic resonance imaging (MRI) findings of patients with anosmia-hyposmia symptoms and to discuss potential mechanisms in light of these findings. Materials and methods: Of the 2412 patients diagnosed with COVID-19-related pneumonia (RT-PCR at least once + clinically confirmed) between March and December 2020, 15 patients underwent olfactory MRI to investigate the cause of ongoing anosmia/ hyposmia symptoms were included in the study. …

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Serum Visfatin Concentrations Are Positively Associated With Ventricular Arrhythmias: A Single-Center Preliminary Study, Rongrong Shen, Peiyu Zhang, Rong Guo, Yawei Xu Jan 2022

Serum Visfatin Concentrations Are Positively Associated With Ventricular Arrhythmias: A Single-Center Preliminary Study, Rongrong Shen, Peiyu Zhang, Rong Guo, Yawei Xu

Turkish Journal of Medical Sciences

Background/aim: Visfatin has been reported to be closely related to cardiovascular diseases associated with inflammation, but the correlation between visfatin and ventricular arrhythmia (VA) has not been discussed yet. The study aims to explore the association between serum visfatin concentrations and VA in patients. Materials and methods: Sixty-seven hospitalized patients diagnosed with VA and 131 control subjects were enrolled in this crosssectional study between May 20, 2017 and November 8, 2019. Classification of VA types was based on the presence of structural heart disease (SHD). The patients? blood samples were collected to examine their serum levels of visfatin. Results were …

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What Is The Protective Effect Of Preischemic Kisspeptin-10 Administration Against Ischemia/Reperfusion Injury Of Striatum On Mice?, Hati̇ce Akkaya, Engi̇n Sümer, Seli̇m Kutlu, Hati̇ce Solak, Bayram Yilmaz Jan 2022

What Is The Protective Effect Of Preischemic Kisspeptin-10 Administration Against Ischemia/Reperfusion Injury Of Striatum On Mice?, Hati̇ce Akkaya, Engi̇n Sümer, Seli̇m Kutlu, Hati̇ce Solak, Bayram Yilmaz

Turkish Journal of Medical Sciences

Background/aim: Kisspeptin is a neuropeptide with a primary role on the onset of puberty and has beneficial effects on ischemia/ reperfusion (I/R) injury. In this study, we aimed to investigate the effect of kisspeptin administration on striatal I/R injury in mice. Material and methods: Forty adult C57/BL6 mice were randomly divided into four groups: Sham, Kisspeptin, I/R, and I/R + Kisspeptin groups. The groups were administered with either physiological saline (Sham and I/R groups) or kisspeptin (Kisspeptin and I/R + Kisspeptin groups) intraperitoneally 40 min before the operation. A microdialysis probe was placed in the right striatum according to stereotaxic …

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The Use Of Fulvestrant Before Chemotherapy Improves Survival In Hormone-Positive Breast Cancer: A Real-Life Study, Deni̇z Can Güven, Hasan Çağri Yildirim, Enes Erul, Taha Koray Şahi̇n, İbrahi̇m Yahya Çakir, Oktay Hali̇t Aktepe, Neyran Kertmen, Ömer Di̇zdar, Sercan Aksoy Jan 2022

The Use Of Fulvestrant Before Chemotherapy Improves Survival In Hormone-Positive Breast Cancer: A Real-Life Study, Deni̇z Can Güven, Hasan Çağri Yildirim, Enes Erul, Taha Koray Şahi̇n, İbrahi̇m Yahya Çakir, Oktay Hali̇t Aktepe, Neyran Kertmen, Ömer Di̇zdar, Sercan Aksoy

Turkish Journal of Medical Sciences

Background/aim: We aimed to evaluate the efficacy of fulvestrant and its affecting clinical factors, including the optimal sequencing of fulvestrant and chemotherapy in a real-life cohort. Methods: The data of 256 metastatic hormone-positive breast cancer patients treated with fulvestrant were evaluated. The association of clinical factors with survival was analyzed with Kaplan-Meier and Cox-regression analyses. Results: The median age of patients was 57 years. More than half of the patients used fulvestrant in later lines and after chemotherapy (75.8%). The median progression-free (PFS) and overall survival (OS) of all cohort were 6.05 ± 0.56 and 29.70 ± 1.61 months, respectively. …

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Retrospective Comparison Of Flot And Modified Dcf As First-Line Chemotherapy In Metastatic Gastric Adenocarcinoma, Fati̇h Gürler, Deni̇z Can Güven, Ergi̇n Aydemi̇r, Osman Sütcüoğlu, Bedi̇z Kurt İnci̇, Zafer Arik, Şuayi̇b Yalçin, Nuri̇ye Özdemi̇r, Ahmet Özet, Ozan Yazici Jan 2022

Retrospective Comparison Of Flot And Modified Dcf As First-Line Chemotherapy In Metastatic Gastric Adenocarcinoma, Fati̇h Gürler, Deni̇z Can Güven, Ergi̇n Aydemi̇r, Osman Sütcüoğlu, Bedi̇z Kurt İnci̇, Zafer Arik, Şuayi̇b Yalçin, Nuri̇ye Özdemi̇r, Ahmet Özet, Ozan Yazici

Turkish Journal of Medical Sciences

Background/aim: The aim of our study was to compare the efficacy and the safety of the FLOT and the modified DCF (mDCF) regimens in patients with metastatic gastric (GC) and gastroesophageal junction (GEJ) adenocarcinoma as first-line treatment. Materials and methods: The medical records of 72 patients were retrospectively reviewed. Survivals and hematological adverse events of the patients were examined. Factors affecting survivals were analyzed in univariate analysis. A multivariate analysis was performed with the factors contributing to survivals in univariate analysis. Results: The median PFS (mPFS) was 10.1 months (95% CI, 6.8?13.4) in the FLOT arm (n = 33) and …

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The Lateralization Accuracy Of Inferior Petrosal Sinus Sampling In Cushing?S Disease: Experiences Of A Tertiary Center, Eli̇f Tutku Durmuş, Ayşegül Atmaca, Fati̇h Uzunkaya, Rami̇s Çolak, Buğra Durmuş Jan 2022

The Lateralization Accuracy Of Inferior Petrosal Sinus Sampling In Cushing?S Disease: Experiences Of A Tertiary Center, Eli̇f Tutku Durmuş, Ayşegül Atmaca, Fati̇h Uzunkaya, Rami̇s Çolak, Buğra Durmuş

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study is to determine the accuracy of bilateral inferior petrosal sinus sampling (IPSS) in lateralization and to investigate variables associated with accurate IPSS lateralization prediction. Materials and methods: Initially, data from 55 patients who underwent IPSS in our institution were reviewed retrospectively. IPSS lateralization and pituitary magnetic resonance imaging (MRI) results of these patients were compared with postoperative follow-up and immunohistochemical data to calculate the positive predictive values (PPVs) for IPSS and MRI. Variables likely to be associated with the accurate prediction of IPSS lateralization were analyzed. Results: Twenty-seven patients (85.2% female, mean age of …

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Is Condyle Morphology A Factor For Anterior Temporomandibular Disc Displacement?, İlkay Çamlidağ, Asli Tanrivermi̇ş Sayit, Muzaffer Elmali Jan 2022

Is Condyle Morphology A Factor For Anterior Temporomandibular Disc Displacement?, İlkay Çamlidağ, Asli Tanrivermi̇ş Sayit, Muzaffer Elmali

Turkish Journal of Medical Sciences

Background/aim: To investigate morphological features of the mandibular condyle and its association with anterior temporomandibular disc displacement on sagittal oblique MRI plane. Materials and methods: One hundred and twenty patients with temporomandibular MRI examination were retrospectively involved in the study. Patients aged less than 18 years and those with severe osteoarthritis, posterior disk displacement, tumor, abscess, history of a rheumatic disease, facial trauma, and motion artifacts on images were excluded. Three radiologists evaluated all images in consensus. Temporomandibular disc locations were classified as normal, anteriorly displaced with reduction (ADr), and anteriorly displaced without reduction (ADwr) on sagittal oblique T1-weighted images. …

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Using Electrooculography With Visual Stimulus Tracking Test In Diagnosing Of Adhd: Findings From Machine Learning Algorithms, Fatma Lati̇foğlu, Mustafa Yasi̇n Esas, Rami̇s İleri̇, Sevgi̇ Özmen, Esra Demi̇rci̇ Jan 2022

Using Electrooculography With Visual Stimulus Tracking Test In Diagnosing Of Adhd: Findings From Machine Learning Algorithms, Fatma Lati̇foğlu, Mustafa Yasi̇n Esas, Rami̇s İleri̇, Sevgi̇ Özmen, Esra Demi̇rci̇

Turkish Journal of Medical Sciences

Background/aim: Attention deficit hyperactivity disorder (ADHD), one of the most common neurodevelopmental disorders in childhood, is diagnosed clinically by assessing the symptoms of inattention, hyperactivity, and impulsivity. Also, there are limited objective assessment tools to support the diagnosis. Thus, in this study, a new electrooculography (EOG) based on visual stimulus tracking to support the diagnosis of ADHD was proposed. Materials and methods: Reference stimulus one-to-one tracking numbers (RSOT) and colour game detection (CGD) were applied to 53 medication-free children with ADHD and 36 healthy controls (HCs). Also, the test was applied six months after the treatment to children with ADHD. …

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Morphometric Examination Of Trigeminal Nerve And Its Adjacent Structures In Patients With Trigeminal Neuralgia: A Case-Control Study, Yunus Emre Kundakci, Nadi̇re Ünver Doğan, İnci̇ Kara, Mehmet Öztürk, Zeli̇ha Fazlioğullari, Ahmet Kağan Karabulut Jan 2022

Morphometric Examination Of Trigeminal Nerve And Its Adjacent Structures In Patients With Trigeminal Neuralgia: A Case-Control Study, Yunus Emre Kundakci, Nadi̇re Ünver Doğan, İnci̇ Kara, Mehmet Öztürk, Zeli̇ha Fazlioğullari, Ahmet Kağan Karabulut

Turkish Journal of Medical Sciences

Background/aim: Morphological differences that can lead the trigeminal nerve to neurovascular conflict and a new solitary pontine lesion are associated with the pathogenesis of trigeminal neuralgia (TN). In this case-control study, we aimed to contribute to the current discussions about the pathogenesis of TN by investigating the anatomical structures that may have an effect on the morphometric parameters of the trigeminal nerve. Materials and methods: This study included 25 patients with TN followed up for pain in the Department of Algology, Faculty of Medicine, and 25 age- and gender-matched controls. We performed morphometric measurements including the length and volume of …

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Concordance Of Vestibular Test Batteries In Patients With Vestibular Neuritis, Burak Kabi̇ş, Hakan Tutar, Emre Gürses, Bülent Gündüz, Songül Aksoy Jan 2022

Concordance Of Vestibular Test Batteries In Patients With Vestibular Neuritis, Burak Kabi̇ş, Hakan Tutar, Emre Gürses, Bülent Gündüz, Songül Aksoy

Turkish Journal of Medical Sciences

Background/aim: A growing number of vestibular function tests are utilized to differentiate and verify the diagnosis of vestibular neuritis. The aim of this study is to retrospectively investigate the consistency of the results of the objective vestibular test batteries in patients with a preliminary diagnosis of vestibular neuritis. Materials and methods: We reviewed a total of 37 adult patients (mean age: 39.03 ± 11.67, 19 females, 18 males) who met the inclusion criteria with a prediagnosis of vestibular neuritis from 379 patients suffering vestibular symptoms. Caloric test (CVT), video head impulse test (vHIT), and ocular and cervical VEMP tests were …

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Can The Hummingbird Sign Contribute To The Diagnosis Of Idiopathic Normal Pressure Hydrocephalus?, Hali̇l Önder, Selcuk Çomoğlu Jan 2022

Can The Hummingbird Sign Contribute To The Diagnosis Of Idiopathic Normal Pressure Hydrocephalus?, Hali̇l Önder, Selcuk Çomoğlu

Turkish Journal of Medical Sciences

To the Editor,

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Copy Number Variations In Patients With Idiopathic Recurrent Pregnancy Loss: An Arraycgh Approach, Onur Yildiz, Fatma Silan, Taner Karakaya, Öztürk Özdemi̇r Jan 2022

Copy Number Variations In Patients With Idiopathic Recurrent Pregnancy Loss: An Arraycgh Approach, Onur Yildiz, Fatma Silan, Taner Karakaya, Öztürk Özdemi̇r

Turkish Journal of Medical Sciences

Background/aim: It is not always possible to determine the causative basis of pregnancy losses and even today it has been reported that 50% of cases with recurrent pregnancy loss (RPL) have no reason to be detected. In our study, it is aimed to reveal the copy number variations (CNVs) of the genes which presumably have a potential effect in individuals with RPL and contribute to subsequent functional studies in the follow-up. Materials and methods: We retrospectively evaluated the array-comparative genomic hybridization (aCGH) data of cytogenetically 64 normal individuals (21 couples, 11 unrelated women, and 11 unrelated men) who had applied …

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The Respiratory Manifestations In Patients With Primary Sjögren?S Syndrome: Is Interstitial Lung Disease Related To Disease Activity?, Özlem Özdemi̇r Işik, Ayten Yazici, Ayşe Çefle Jan 2022

The Respiratory Manifestations In Patients With Primary Sjögren?S Syndrome: Is Interstitial Lung Disease Related To Disease Activity?, Özlem Özdemi̇r Işik, Ayten Yazici, Ayşe Çefle

Turkish Journal of Medical Sciences

Background/aim: Sjögren?s syndrome is a systemic, autoimmune disease and can affect many organs and systems. In this study, we aimed to evaluate the respiratory manifestations, and the association between interstitial lung disease (ILD) and disease activity in primary SS (pSS) patients. Materials and methods: The study design was retrospective cross-sectional, and 151 patients followed up with a diagnosis of pSS between 2004 and 2019 were included in the study. Demographic and clinical data, laboratory results, chest radiographs and thorax computed tomography (CT) results were obtained from patient files and hospital imaging system. Thorax CT was requested from all patients with …

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Is The Treatment Of Inflammatory Arthritis Different In Sickle Cell Disease?, Gezmi̇ş Ki̇myon, Gül İlhan Jan 2022

Is The Treatment Of Inflammatory Arthritis Different In Sickle Cell Disease?, Gezmi̇ş Ki̇myon, Gül İlhan

Turkish Journal of Medical Sciences

Background/aim: Musculoskeletal findings are common in sickle cell patients and may be confused with inflammatory arthritis. In addition, complications such as frequent infections may create difficulties while choosing drugs such as steroids, methotrexate, or antiTNFs. Our aim is to reveal whether the treatment is different in sickle cell patients with rheumatic diseases such as rheumatoid arthritis. Materials and methods: Patients followed by Rheumatology and Hematology divisions of Hatay Mustafa Kemal University Hospital were retrospectively screened. Excluding patients with musculoskeletal findings associated with sickle cell disease (SCD), patients with chronic or acute inflammatory arthritis were enrolled into study. Demographic data, disease …

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Validation And Cross-Cultural Adaptation Of The Turkish Version Of The Revised Leeds Disability Questionnaire In Patients With Ankylosing Spondylitis, Mehmet Özkeski̇n, Fati̇h Özden, Özge Ocaker Aktan, Tuba Demi̇rci̇ Yildirim, İsmai̇l Sari Jan 2022

Validation And Cross-Cultural Adaptation Of The Turkish Version Of The Revised Leeds Disability Questionnaire In Patients With Ankylosing Spondylitis, Mehmet Özkeski̇n, Fati̇h Özden, Özge Ocaker Aktan, Tuba Demi̇rci̇ Yildirim, İsmai̇l Sari

Turkish Journal of Medical Sciences

Background/aim: The revised Leeds Disability Questionnaire (RLDQ) is a unique assessment tool for patients with ankylosing spondylitis (AS); its comprehensive structure includes posture and neck flexibility parameters. The aim of the study was to determine the psychometric properties of the Turkish RLDQ in patients with AS. Materials and methods: A total of 100 AS patients were enrolled in the study. In the first evaluation, patients filled out the Dougados Functional Index (DFI) and Bath Ankylosing Spondylitis Functional Index (BASFI), Stanford Health Assessment Questionnaire (HAQ) in addition to RLDQ. Then, patients were refilled the revised RLDQ in the second assessment. Results: …

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Cover And Contents Jan 2022

Cover And Contents

Turkish Journal of Medical Sciences

No abstract provided.

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A Comparison Of Antibody Response In Kidney Transplant Recipients And Healthcare Workers Who Had Pcr-Confirmed Covid-19 Infection, Mevlüt Tamer Di̇ncer, Necmi̇ Eren, Ahmet Murt, Nuri̇ye Yildiz, Şeyda Gül Özcan, Meti̇n Ergül, Si̇bel Gökçay Bek, Zeynep Atli, Si̇nan Trabulus, Erkan Dervi̇şoğlu, Hamdi̇ Levent Doğanay, Nurhan Seyahi̇ Jan 2022

A Comparison Of Antibody Response In Kidney Transplant Recipients And Healthcare Workers Who Had Pcr-Confirmed Covid-19 Infection, Mevlüt Tamer Di̇ncer, Necmi̇ Eren, Ahmet Murt, Nuri̇ye Yildiz, Şeyda Gül Özcan, Meti̇n Ergül, Si̇bel Gökçay Bek, Zeynep Atli, Si̇nan Trabulus, Erkan Dervi̇şoğlu, Hamdi̇ Levent Doğanay, Nurhan Seyahi̇

Turkish Journal of Medical Sciences

Background/aim: Data on antibody response following COVID-19 in kidney transplant recipients is scarce. This crosssectional study aims to investigate the antibody response to COVID-19 among kidney transplant recipients. Materials and methods: We recruited 46 kidney transplant recipients with RT-PCR-confirmed COVID-19 and 45 recipients without COVID-19 history. We also constructed two control groups (COVID-19 positive and negative) from a historical cohort of healthcare workers. We used age and sex-based propensity score matching to select the eligible subjects to the control groups. We measured the SARS-CoV-2 IgG levels quantitatively using the Abbott ARCHITECT system. An antibody level above 1.4 S/C was defined …

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Covid-19 In Pediatric Nephrology Centers In Turkey, Emre Leventoğlu, Yeşi̇m Özdemi̇r Ati̇kel, Hülya Nalçacioğlu, İsmai̇l Dursun, Hasan Dursun, Zeynep Nagehan Yürük Yildirim, Nurdan Yildiz, Gülşah Kaya Aksoy, Mehmet Taşdemi̇r, Mehtap Çelakil, Belti̇nge Demi̇rci̇oğlu Kiliç, Şenay Zirhli Selçuk, Nur Canpolat, Evri̇m Kargin Çakici, Sare Gülfem Özlü Jan 2022

Covid-19 In Pediatric Nephrology Centers In Turkey, Emre Leventoğlu, Yeşi̇m Özdemi̇r Ati̇kel, Hülya Nalçacioğlu, İsmai̇l Dursun, Hasan Dursun, Zeynep Nagehan Yürük Yildirim, Nurdan Yildiz, Gülşah Kaya Aksoy, Mehmet Taşdemi̇r, Mehtap Çelakil, Belti̇nge Demi̇rci̇oğlu Kiliç, Şenay Zirhli Selçuk, Nur Canpolat, Evri̇m Kargin Çakici, Sare Gülfem Özlü

Turkish Journal of Medical Sciences

Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey. Materials and methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11th March 2020 and 11th March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry. Results: Two hundred and three patients (89 girls and 114 boys) were diagnosed with COVID-19. One-third of these patients (36.9%) were between 10-15 years old. Half of the patients were on kidney replacement …

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Could Lactate Clearance Be A Marker Of Mortality In Pediatric Intensive Care Unit?, Özlem Saraç Sandal, Gökhan Ceylan, Ferhat Sari, Gülhan Atakul, Mustafa Çolak, Sevgi̇ Topal, Eki̇n Soydan, Ünal Utku Karaarslan, Hasan Ağin Jan 2022

Could Lactate Clearance Be A Marker Of Mortality In Pediatric Intensive Care Unit?, Özlem Saraç Sandal, Gökhan Ceylan, Ferhat Sari, Gülhan Atakul, Mustafa Çolak, Sevgi̇ Topal, Eki̇n Soydan, Ünal Utku Karaarslan, Hasan Ağin

Turkish Journal of Medical Sciences

Background/aim: Hyperlactatemia is a common finding in critically ill patients and has significant prognostic implications. However, a single lactate measurement has not been correlated to mortality consistently. In this study, we aimed to correlate the clinical efficacy of lactate clearance for the prediction of mortality in pediatric intensive care unit patients. Materials and methods: This retrospective observational study was performed in the pediatric intensive care unit in patients with lactate level >3 mmol/lt. Initial, 6th h, and 24th h lactate levels were recorded and lactate clearance was calculated using these values (lactate level at admission - level 6 h later …

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Can Surfactants Affect Mortality And Morbidity In Term Infants With Respiratory Failure?, Senem Alkan Özdemi̇r, Özlem Yilman, Şebnem Çalkavur, Tüli̇n Gökmen Yildirim Jan 2022

Can Surfactants Affect Mortality And Morbidity In Term Infants With Respiratory Failure?, Senem Alkan Özdemi̇r, Özlem Yilman, Şebnem Çalkavur, Tüli̇n Gökmen Yildirim

Turkish Journal of Medical Sciences

Background/aim: We aimed to discuss term infants who are given surfactant due to respiratory disorder according to the underlying etiology, the dose of surfactant administration, and the need for repeated surfactant administration. Materials and methods: In this retrospective study infants hospitalized in the 4th level neonatal intensive care unit during January 2019 and December 2021 and administered surfactant due to respiratory distress were included. Term infants given surfactant due to respiratory failure were included in the study through the data recording system. The number of surfactant doses, indications for administration, mortality, duration of hospitalization, intubation time, and inotrope use were …

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The Effect Of Comprehensive Multidisciplinary Pulmonary Rehabilitation On 5-Year Survival In Copd: Does Maintaining A Home Exercise Program Improve Survival?, Seher Satar, Mustafa Engi̇n Şahi̇n, Pinar Ergün Jan 2022

The Effect Of Comprehensive Multidisciplinary Pulmonary Rehabilitation On 5-Year Survival In Copd: Does Maintaining A Home Exercise Program Improve Survival?, Seher Satar, Mustafa Engi̇n Şahi̇n, Pinar Ergün

Turkish Journal of Medical Sciences

Background/aim: Chronic Obstructive Pulmonary Disease (COPD) is one of the most common causes of death worldwide. Therefore, optimizing medical therapy in the comprehensive management of the disease, as well as including pulmonary rehabilitation (PR) in the treatment, is essential. The goal of our study was to determine the impact of PR on the survival of COPD patients. Materials and methods: Between 2007-2015, 509 COPD patients who completed the PR constituted the PR group, while 167 patients who applied but could not complete it after the initial evaluations formed the control group. In the PR group, dyspnea perception, exercise capacity, muscle …

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Association Of Trinucleotide Repeat Polymorphisms Cag And Ggc In Exon 1 Of The Androgen Receptor Gene With Male Infertility: A Cross-Sectional Study, Mussarat Ashraf, Dr. Shahana Urooj Kazmi, Hemaila Tariq, Adnan Munir, Rehana Rehman Jan 2022

Association Of Trinucleotide Repeat Polymorphisms Cag And Ggc In Exon 1 Of The Androgen Receptor Gene With Male Infertility: A Cross-Sectional Study, Mussarat Ashraf, Dr. Shahana Urooj Kazmi, Hemaila Tariq, Adnan Munir, Rehana Rehman

Turkish Journal of Medical Sciences

Background/aim: Infertility is a global problem that brings about serious sexual and social consequences that strain the health sector and society. The expansion of CAG and GGC repeats in androgen receptor (AR) gene (Ensembl number ENSG00000169083) may lead to reduced fertility. Our objective was to determine the association of CAG and GGC repeats with altered sperm parameters in male infertile subjects. Materials and methods: This was a cross-sectional study conducted at Aga Khan University, Karachi, Pakistan. A total of 376 males were recruited, out of which group A (N = 208) and group B (N = 168) were comprised of …

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Role Of Pd-1/Pd-L1-Mediated Tumour Immune Escape Mechanism And Microsatellite Instability In The Bcg Failure Of High-Grade Urothelial Carcinomas, Fadi̇me Gül Salman, Duygu Kankaya, Hi̇lal Özakinci, Yasemi̇n Şahi̇n, Eralp Kubi̇lay, Evren Süer, Serhat Hayme, Sümer Baltaci Jan 2022

Role Of Pd-1/Pd-L1-Mediated Tumour Immune Escape Mechanism And Microsatellite Instability In The Bcg Failure Of High-Grade Urothelial Carcinomas, Fadi̇me Gül Salman, Duygu Kankaya, Hi̇lal Özakinci, Yasemi̇n Şahi̇n, Eralp Kubi̇lay, Evren Süer, Serhat Hayme, Sümer Baltaci

Turkish Journal of Medical Sciences

Background/aim: Intravesical BCG treatment fails inexplicably in 30%-45% of patients for high-grade nonmuscle-invasive bladder cancer (NMIBC). We aimed to investigate the role of PD-1/PD-L1 interaction on BCG failure of high-grade NMIBC and to identify biomarkers for predicting BCG responsive cases. Materials and methods: Thirty BCG responsive and 29 nonresponsive NMIBCs were included in the study. Expressions of PDL1(SP-263), MSH2, MSH6, PMS2, and MLH1 were evaluated on pre- and post-BCG transurethral resection (TUR-B) specimens by immunohistochemistry. PD-L1(SP-263) expression was categorised as negative/low, high. DNA mismatch repair protein (MMR) expressions were classified as 'reduced' if ≤30% of nuclei stained, 'preserved' if >30% …

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