Digital Commons Network^™

Remdesivir Analog As Sars-Cov-2 Polymerase Inhibitor: Virtual Screening Of A Database Generated By Scaffold Replacement, Amgad Albohy, Mohamed A. Said, Mohamed A. Abdelrahman, Hany Said

Pharmacy

By the end of 2019, a novel strain of the corona viral family named SARS-CoV-2 emerged in Wuhan, China and started to spread worldwide causing one of the most dangerous lethal pandemics. Researchers utilized various reported inhibitors and drug databases for virtual screening analysis against this novel strain. Later on, they succeeded to fish and repurpose remdesivir, an antiviral nucleotide analogue that inhibits RNA polymerase of the Ebola virus, as a promising candidate against SARS-CoV-2. In this study, we used the interactions of the co-crystallized metabolite of remdesivir with SARS-CoV-2 RdRp isozyme (PDB 7BV2) to design an analog with potential …

Considering Thickness-Accommodation, Nesting, Grounding And Deployment In Design Of Miura-Ori Based Space Arrays, Terri Bateman, Diana Bolanos, Nathan Brown, Brooklyn Clark, Larry L. Howell, Collin Ynchausti, Hunter Pruett, Jared Hunter, Spencer P. Magleby

Faculty Publications

The Miura-ori pattern exhibits favorable qualities desirable for deployable space arrays – especially achieving a large deployed area from a compact stowed volume. However, implementing the Miura-ori into a finite-thickness, engineered system poses challenges that are not manifest in a zero-thickness model. As such, it is important to understand and address the limitations of the pattern before implementing it into an engineered system. This paper presents the Miura-ori as a favorable, yet challenging, pattern in design of deployable space arrays. Challenges including thickness-accommodation, nesting, grounding and deployment are presented to introduce designers to unapparent complications associated with design of Miura-ori …

Local Context And Post-Crisis Social Venture Creation, Sergey Anokhin, Todd Morgan, Lisa Jones Christensen, William Schulze

Faculty Publications

Research summary: We investigate the effects of local market and government failure on the creation of social ventures in the context of post-crisis recovery during the period following the dot-com crisis and ending before the housing bubble burst across all Ohio counties. Drawing on social embeddedness theory, we posit that social venture creation rates vary across local contexts and are higher in communities characterized by market and government failures. Longitudinal contextual data from 88 Ohio counties indicates that situations characterized by failures of both types are especially conducive to the creation of local social enterprises. We address the shortage of …

Religious Affiliation’S Association With Suicidality Across Sexual Orientations And Gender Identities, W. Justin Dyer, Michael A. Goodman

Faculty Publications

The objective was to replicate and extend earlier findings examining the intersection of sexual orientation and religious affiliation predicting suicidality. Current analyses used updated data and extended prior work by examining how affiliation relates to suicidality for transgender individuals. Data were collected in 2021 from 46,562 adolescents and were representative of Utah adolescents in grades 8, 10, and 12. In regressions, affiliation predicted suicidality and subsequent models added demographics, family functioning, drug use, feeling socially integrated, and interaction terms between sexual orientation, gender identity, and affiliation. In baseline models, affiliation was related to fewer mental health difficulties. When including drug …

When Is Enough, Enough? An Examination Of Student Engagement When Watching Online Group Project Presentations, Manasvi Kumar, Joseph S. Valacich, Jeffrey L. Jenkins, David Kim

Faculty Publications

In traditional face-to-face classes, conventional wisdom suggests that delivering and watching group project presentations is a valuable learning experience. In this research, we examine the limits of student engagement and learning in an asynchronous online context. Specifically, 249 undergraduate students were assigned to perform peer evaluations of multiple ten-minute project presentations. The online learning platform collected objective viewing behavior for each student, allowing us to use viewing time as a proxy for engagement. We also collected self-reported attitudes towards the assignment, finding that while students value providing feedback, they do not consider it a valuable use of their time. Students …

Too Fast? Too Slow? A Novel Approach For Identifying Extreme Response Behavior In Online Surveys, Manasvi Kumar, Joseph S. Valacich, Jeffrey L. Jenkins, David Kim

Faculty Publications

Some participants of online surveys engage in extreme answering behavior while generating responses (i.e., they respond too fast or too slow) relative to population norms. Here, we demonstrate how participants’ navigation behaviors can be used to potentially identify such responses. We administered an online survey where students (who were earlier instructed to complete a task) report lenience scores towards non-appropriate behavior while completing the task. We draw on cognitive dissonance theory to posit that failure to follow instruction predicts lenience scores. We then created different datasets by excluding data from participants flagged by our metrics and generated predictive models. We …

Do Privacy Assurances Work? A Study Of Truthfulness In Healthcare History Data Collection, Tamara M. Masters, Mark Keith, Rachel Hess, Jeffrey L. Jenkins

Faculty Publications

Patients often provide untruthful information about their health to avoid embarrassment, evade treatment, or prevent financial loss. Privacy disclosures (e.g. HIPAA) intended to dissuade privacy concerns may actually increase patient lying. We used new mouse trackingbased technology to detect lies through mouse movement (distance and time to response) and patient answer adjustment in an online controlled study of 611 potential patients, randomly assigned to one of six treatments. Treatments differed in the notices patients received before health information was requested, including notices about privacy, benefits of truthful disclosure, and risks of inaccurate disclosure. Increased time or distance of device mouse …

What Makes Health Data Privacy Calculus Unique? Separating Probability From Impact, Mark Keith, Autumn Clark, Tamara Masters, Curtis Wigington

Faculty Publications

Patient health data is heavily regulated and sensitive. Patients will sometimes falsify data to avoid embarrassment resulting in misdiagnoses and even death. Existing research to explain this phenomenon is scarce with little more than attitudes and intents modeled. Similarly, health data disclosure research has only applied existing theories with additional constructs for the healthcare context. We argue that health data has a fundamentally different cost/benefit calculus than the non-health contexts of traditional privacy research. By separating the probability of disclosure risks and benefits from the impact of that disclosure, it is easier to understand and interpret health data disclosure. In …

Uncommon Ground: Grant Wood And Russell Lee's Divergent View Of Iowa, James R. Swensen

Faculty Publications

GRANT WOOD'S American Gothic (1930) has likely been reproduced, parodied, and lampooned more than any other painting in American history (Figure 1). As scholars Wanda Corn, Steven Biel, and others have observed, the scene of an Iowa farmer and his daughter (often erroneously thought to be his wife) has proven to be remarkably adaptable for nearly a century.¹ An early example of its adoption occurred 11 years after Wood's work was finished, when it was appropriated by Gordon Parks, a young Black photographer. Created for the Farm Security Administration (FSA) and under the aegis of administrator Roy Stryker, Parks …

Psycholinguistic Profiling Of Children With Sluggish Cognitive Tempo, Kirsten M. Russell, Sean M. Redmond, Andrea C. Ash

Faculty Publications

Language disorders are frequently comorbid with attention deficit/hyperactivity disorder (ADHD). Sluggish cognitive tempo (SCT),a second attention disorder, may potentially explain some of the links between language disorders and ADHD. In this study we examined the psycholinguistic abilities of 207 children (mean age 7;10) with and without clinically significant levels of SCT symptoms to determine the degree to which symptoms of language disorder co-occur in cases of SCT. Analyses of children’s tense-marking, nonword repetition, and sentence recall indicated that deficits in these areas were not associated with SCT. Instead, SCT appears to be more closely aligned with features of social (pragmatic) …

Representation Of Race And Ethnicity In Counseling And Counseling Psychology Journals, Jared M. Hawkins, Roy A. Bean, Timothy B. Smith, Jonathan G. Sandberg

Faculty Publications

Whereas previous literature reviews have concluded that people of color are underrepresented in psychological literature, the fields of counseling and counseling psychology have taken a clear affirmative stance with respect to human diversity. This study sought to evaluate the representation of people of color in four key journals across the 2000-2019 timespan: The Counseling Psychologist, Journal of Counseling Psychology, Journal of Counseling & Development, and Counselling Psychology Quarterly. Journal articles were coded for several variables, including focus on racial/ethnic minority (REM) groups and article content topics. Results indicated that 757 (26.3%) of the articles were coded REM-focused. Of …

Multidimensional Signals And Analytic Flexibility: Estimating Degrees Of Freedom In Human-Speech Analyses, Stefano Coretta, Joseph V. Casillas, Joseph A. Stanley, Timo B. Roettger

Faculty Publications

Recent empirical studies have highlighted the large degree of analytic flexibility in data analysis that can lead to substantially different conclusions based on the same data set. Thus, researchers have expressed their concerns that these researcher degrees of freedom might facilitate bias and can lead to claims that do not stand the test of time. Even greater flexibility is to be expected in fields in which the primary data lend themselves to a variety of possible operationalizations. The multidimensional, temporally extended nature of speech constitutes an ideal testing ground for assessing the variability in analytic approaches, which derives not only …

Order Of Operations In Sociophonetic Analysis, Joseph A. Stanley

Faculty Publications

In modern sociophonetic data analysis, a researcher makes numerous decisions when processing their data. Many of the “big” decisions include how data is collected, how audio is transcribed, how these transcriptions are aligned to the audio, and how acoustic measurements are extracted. Once a spreadsheet of numbers has been generated, further decisions must be made regarding normalization, detecting and handling outliers, and excluding tokens irrelevant to the research question. This paper takes a closer look at this second group of decisions—those made after acoustic measurements have been extracted—and shows that the order in which they are applied can have significant …

How Sample Size Impacts Pillai Scores: And What Sociophoneticians Should Do About It, Joseph A. Stanley, Betsy Sneller

Faculty Publications

Pillai scores in Sociolinguistics

• A way to quantify overlap in multiple dimensions (e.g., F1, F2, duration) (Hay et al., 2006; Nycz & Hall-Lew 2013)
• Some concern about unequal vowel categories sizes (Johnson 2015; convo on Twitter June 2, 2021)
• Our solution: a big simulation to show exactly what impact sample size has on Pillai scores

The Simulation

1. Start with a single bivariate normal distribution.

2. Sample two “vowel classes” from this distribution. – Ground Truth is they’re merged.

3. Calculate the Pillai score – Should be close to 0 because they’re merged!

4. Repeat many, many times.

Generational Change In Formant Trajectories: The Low-Back-Merger Shift In Longview, Washington, Joseph A. Stanley

Faculty Publications

How have vowel formant trajectories changed as part of the LBMS?

As the front lax vowels lower and centralize, their formant dynamics change

• Specifically, F2 is less dynamic, resulting in a “bounce” shape in F1-F2 plots.
• More evident for lower vowels than higher ones.

Formant dynamics may change as global position changes (but not always).

• Especially true with BAT and BET here.
• BIT mostly unclear.
• BAN did not have substantial changes in vowel dynamics.

Vowels Can Merge Because Of Changes In Trajectory: Prelaterals In Rural Utah English, Joseph A. Stanley, Lisa Morgan Johnson

Faculty Publications

Overview

• Front vowels: tense-lax pairs getting closer in apparent time.
• Back vowels: three-way convergence of WOLF, JOLT, and MULCH.
• This data suggests a merger by approximation.

Expanding to trajectories gives greater insight into this type of merger.

• Kinda like a zipper.

Greater detail in this merger by approximation.

• The nuclei don’t appear to trigger the shift
• The lateral gradually increases its influence, and the nucleus follows.

Trajectories are potentially important for discovering how vowels shift.

• More recent techniques can allow us to answer these questions.

Homogeneity And Heterogeneity In Western American English, Joseph A. Stanley, Jessica Sheperd, Auna Nygaard

Faculty Publications

The Low-Back-Merger Shift (Becker 2019)

Description:

• BAT, BET, BIT lower and retract
• Arguably a chain shift
• Triggered by BOT-retraction
• Typically BAT shifts the most
• BET and especially BIT less shifted

Previous accounts are based on isolated, independent studies.

“Clearly, collecting the same type of data from all sites would be optimal in allowing us the most reliable cross-region assessment.” (Fridland et al. 2017:172)

This study is a direct response to that call.

Methods:

Speakers:

• Recruited via Amazon Mechanical Turk (“MTurk”; cf. Kim et al 2019)
• 85 speakers

Procedure:

• Read 132 sentences and a 300-item wordlist
• Submitted audio 10 sentences at …

The Role Of Emotions As Mechanisms Of Mid-Test Warning Messages During Personality Testing: A Field Experiment, Hairong Li, Jinyan Fan, Guoxiang Zhao, Minghui Wang, Lu Zheng, Hui Meng, Qingxiong Weng, Yanping Liu, Filip Lievens

Research Collection Lee Kong Chian School Of Business

This study focuses on the role of emotions in personnel selection and faking research. In particular, we posit that emotions are likely to be activated when applicants receive warning messages from organizations. Drawing on Nabi (Nabi, Communication Theory, 9, 1999, 292) cognitive-functional model of discrete negative emotions, we propose and empirically test the effects of three discrete negative emotions (guilt, fear, and anger) triggered by a warning message during a personality test on personality score accuracy and perceived test fairness. Participants in this within-subjects field experiment were 1,447 applicants for graduate school at a large public university in China. They …

Microcore: Using Online Playable Cases To Increase Student Engagement In Online Writing Environments, Jon Balzotti, Kevin Haws, Amy A. Rogers, Jason K. Mcdonald, Matt Baker

Faculty Publications

This case study explores a type of educational simulation, an alternative reality game we call a playable case study (PCS), and how its use influenced student engagement in an online writing classroom. The goal of the simulation was to help students create professional communication artifacts and experience real-world professional communication situations. This article reports the effectiveness of the playable case study as a tool specifically for online writing instruction (OWI). The context of our research was a PCS called Microcore. Acting as interns for a company, students are asked to investigate a serious problem that occurs and present a solution …

Temporal Fluency And Floor/Ceiling Scoring Of Intermediate And Advanced Speech On The Actfl Spanish Oral Proficiency Interview–Computer, Troy L. Cox, Alan V. Brown, Gregory L. Thompson

Faculty Publications

The rating of proficiency tests that use the Inter-agency Roundtable (ILR) and American Council on the Teaching of Foreign Languages (ACTFL) guidelines claims that each major level is based on hierarchal linguistic functions that require mastery of multidimensional traits in such a way that each level subsumes the levels beneath it. These characteristics are part of what is commonly referred to as floor and ceiling scoring. In this binary approach to scoring that differentiates between sustained performance and linguistic breakdown, raters evaluate many features including vocabulary use, grammatical accuracy, pronunciation, and pragmatics, yet there has been very little empirical validation …

Mindfulness, Recovery-Stress Balance, And Well-Being Among University Dance Students, Peta Blevins, Gene Moyle, Shona Erskine, Luke Hopper

Research outputs 2014 to 2021

Dance students face many physical and psychological stressors in their training and daily lives, therefore methods for coping with stress are essential for performance enhancement and general wellbeing. This study aimed to investigate the relationships between mindfulness, stress, recovery, and wellbeing among university level vocational dance students. Seventy-two dance students at two Australian universities completed online self-report measures of mindfulness, recovery-stress states, and affect. Correlation coefficients indicated a significant positive relationship between mindfulness and positive affect, and significant negative relationships between mindfulness and stress, and mindfulness and negative affect. MANOVA revealed differences between high mindfulness and low mindfulness groups on …

Performing Kayepa Dordok Living Waters In Noongar Boodjar, South-Western Australia, Clint Bracknell, Pierre Horwitz, Trevor Ryan, Jonathan W. Marshall

Research outputs 2014 to 2021

Performance through language, song and dance provides alternative knowledges and ways of understanding, in this case, developing deeper relationships with living water. Drawing on Indigenous Noongar culture from south-western Australia, this paper addresses the question: How can relationships between living underground, estuarine and riverine water bodies (kayepa dordok) be performed? Two new interlinked Noongar works in response to local riverscapes were developed for, and performed as part of, the 2021 Perth Festival. The first was to embody the return journey of the bullshark, from the salt water to the riverine fresh water; the second was to enact the …

Utilising A Systematic Review-Based Approach To Create A Database Of Individual Participant Data For Meta- And Network Meta-Analyses: The Release Database Of Aphasia After Stroke, Louise R. Williams, Myzoon Ali, Kathryn Vandenberg, Linda J. Williams, Masahiro Abo, Frank Becker, Audrey Bowen, Caitlin Brandenburg, Caterina Breitenstein, Stefanie Bruehl, David A. Copland, Tamara B. Cranfill, Marie Di Pietro-Bachmann, Pamela Enderby, Joanne Fillingham, Federica Lucia Galli, Marialuisa Gandolfi, Bertrand Glize, Erin Godecke, Neil Hawkins, Katerina Hilari, Jacqueline Hinckley, Simon Horton, David Howard, Petra Jaecks, Elizabeth Jefferies, Luis M T Jesus, Maria Kambanaros, Eun K. Kang, Eman M. Khedr, Anthony P H Kong, Tarja Kukkonen, Marina Laganaro, Matthew A. Lambon Ralph, Ann C. Laska, Béatrice Leemann, Alexander P. Leff, Roxele R. Lima, Antje Lorenz, Brian Macwhinney, Rebecca S. Marshall, Flavia Mattioli, İlknur Maviş, Marcus Meinzer, Reza Nilipour, Enrique Noé, Nam-Jong Paik, Rebecca Palmer, Ilias Papathanasiou, Brigida F. Patricio, Isabel P. Martins, Cathy Price, Tatjana P. Jakovac, Elizabeth Rochon, Miranda L. Rose, Charlotte Rosso, Ilona Rubi-Fessen, Marina B. Ruiter, Claerwen Snell, Benjamin Stahl, Jerzy P. Szaflarski, Shirley A. Thomas, Mieke Van De Sandt-Koenderman, Ineke Van Der Meulen, Evy Visch-Brink, Linda Worrall, Heather H. Wright, Marian C. Brady, The Release Collaborators

Research outputs 2014 to 2021

Background: Collation of aphasia research data across settings, countries and study designs using big data principles will support analyses across different language modalities, levels of impairment, and therapy interventions in this heterogeneous population. Big data approaches in aphasia research may support vital analyses, which are unachievable within individual trial datasets. However, we lack insight into the requirements for a systematically created database, the feasibility and challenges and potential utility of the type of data collated. Aim: To report the development, preparation and establishment of an internationally agreed aphasia after stroke research database of individual participant data (IPD) to facilitate planned …

Breech Presentation Management: A Critical Review Of Leading Clinical Practice Guidelines, Sara Morris, Sadie Geraghty, Deborah Sundin

Research outputs 2014 to 2021

Problem

Clinical practice guidelines are designed to guide clinicians and consumers of maternity services in clinical decision making, but recommendations are often consensus based and differ greatly between leading organisations.

Background

Breech birth is a divisive clinical issue, however vaginal breech births continue to occur despite a globally high caesarean section rate for breech presenting fetuses. Inconsistencies are known to exist between clinical practice guidelines relating to the management of breech presentation.

Aim

The aim of this review was to critically evaluate and compare leading obstetric clinical practice guidelines related to the management of breech presenting fetuses.

Methods

Leading obstetric …

Hydrogen Diffusion In Coal: Implications For Hydrogen Geo‐Storage, Alireza Keshavarz, Hussein R. Abid, Muhammad Ali, Sefan Iglauer

Research outputs 2014 to 2021

Hypothesis

Hydrogen geo-storage is considered as an option for large scale hydrogen storage in a full-scale hydrogen economy. Among different types of subsurface formations, coal seams look to be one of the best suitable options as coal’s micro/nano pore structure can adsorb a huge amount of gas (e.g. hydrogen) which can be withdrawn again once needed. However, literature lacks fundamental data regarding H₂ diffusion in coal.

Experiments

In this study, we measured H₂ adsorption rate in an Australian anthracite coal sample at isothermal conditions for four different temperatures (20 °C, 30 °C, 45 °C and 60 °C), at …

Fatality Risk Management: Applying Quinlan’S Ten Pathways In Western Australia’S Mining Industry, Tanya Jenke, Jessica L. Boylan, Shelley Beatty, Martin Ralph, Andrew Chaplyn, Greg Penney, Marcus Cattani

Research outputs 2014 to 2021

In ‘Ten Pathways to Death and Disaster’ Professor Michael Quinlan (2014) identified a series of ten common catastrophic incident risk factors, known as the Ten Pathways, contributing to major incidents in mining and other high hazard industries. This study applies the Quinlan methodology in two separate phases. The first phase of the study explored employee perception of employer effectiveness of fatality prevention against each of the Ten Pathways through a questionnaire of n = 2009 participants at the 2017–2019 Western Australian Government Mines Safety Roadshows. Respondents generally perceived their employer as having a relatively good understanding of the role of …

Digging For Data: How Sleep Is Losing Out To Roster Design, Sleep Disorders, And Lifestyle Factors, Gemma Maisey, Marcus Cattani, Amanda Devine, Johnny Lo, Shih Ching Fu, Ian C. Dunican

Research outputs 2014 to 2021

Shift workers employed at a remote mining operation may experience sleep loss, impaired alertness, and consequently negative health and safety outcomes. This study determined the sleep behaviors and prevalence of risk for sleep disorders among shift workers; and quantified alertness for a roster cycle. Sleep duration was significantly less following; night shift by 77 ± 7 min and day shift by 30 ± 7 min. The wake after sleep onset was less by 23 ± 3 min for night shifts and 22 ± 3 min for day shifts (p < 0.05 for all). The prevalence of risk for sleep apnea was 31%, insomnia was 8%, and shiftwork disorder was 44%. Average alertness for all working hours was 75%. Shiftwork in remote mining operations is a significant factor that leads to sleep loss and reduced alertness, which is exacerbated by the high prevalence of risk for sleep disorders.

Work-Based Concerns Of Australian Frontline Healthcare Workers During The First Wave Of The Covid-19 Pandemic, Michella Hill, Erin Smith, Brennen W. Mills

Research outputs 2014 to 2021

Objective: This research sought to gauge the extent to which doctors, nurses and paramedics in Australia were concerned about contracting SARS-CoV-2 during the country's first wave of the virus in April 2020.

Methods: Australian registered doctors, nurses and paramedics (n=580) completed an online questionnaire during April 16–30, 2020 (period immediately following the highest four-week period (first wave) of SARS-CoV-2 confirmed cases in Australia).

Results: During April 2020, two-thirds of participants felt it was likely they would contract SARS-CoV-2 at work. Half the participants suggested Personal Protective Equipment (PPE) supplies were inadequate for them to safely perform their job, with two-thirds …

Neuroprotective Effect Of Liraglutide In An Experimental Mouse Model Of Multiple Sclerosis: Role Of Ampk/Sirt1 Signaling And Nlrp3 Infammasome, Marwa Safar

Pharmacy

The heterogeneous nature of multiple sclerosis (MS) and the unavailability of treatments addressing its intricate network and reversing the disease state is yet an area that needs to be elucidated. Liraglutide, a glucagon-like peptide-1 analogue, recently exhibited intriguing potential neuroprotective effects. The currents study investigated its potential effect against mouse model of MS and the possible underlying mechanisms. Demyelination was induced in C57Bl/6 mice by cuprizone (400 mg/kg/day p.o.) for 5 weeks. Animals received either liraglutide (25 nmol/kg/day i.p.) or dorsomorphin, an AMPK inhibitor, (2.5 mg/ Kg i.p.) 30 min before the liraglutide dose, for 4 weeks (starting from the …

A Novel Cyanopyridine Derived Fluorescent Sensor For Selective Determination Of Uranyl Ions In Different Water Samples, Ekram Hany Mohamed, Amany R Salem, Abeer M. El-Naggar,, Mohammed A. Amin,, Mohamed S. S. Attia

Pharmacy

A newly developed spectrofluorometric method is based on the fabrication of an optical cyanopyridine derived sensor, 4-(6-diaryl)-2-oxo -1,2-dihydropyridine-3-carbonitrile using microwave irradiation. The fluorescence intensity of the proposed chemo sensor was obviously quenched in DMSO owing to the presence of UO22+ ions at λex/λem = 320/360 nm. The quenching effect of the cyano-derivative based sensor was found to be proportional to the concentration of UO22+ ion ranging between 9.60 × 10–9–5.28 × 10–5 mol L−1 with a detection and quantification limits of 1.71 × 10–11 and 5.2 × 10–11 mol L−1, respectively. © 2021, Akadémiai Kiadó, Budapest, Hungary.