Digital Commons Network^™

Development Of A Fit-Matching App: Validation Of 3-D Scanning Applications, Jasna Rosser Williams

All ETDs from UAB

According to the National Institute of Occupational Health and Safety (NIOSH), each day nearly 2,000 workers sustain a job-related eye injury that requires medical treatment. It has been reported that the cause of these eye injuries is frequently due to workers not wearing eye protection because it does not fit properly on their faces. To improve the fit of eye protection, we are aiming to develop a fit matching application (app) which will identify the wearers’ better-fitting safety eyewear using 3D technology. We have successfully tested the feasibility of the use of commercially available 3D scanning apps using a mannequin …

Multiplicities Of Polygon Numbers, Alyssa R. Wilke

All ETDs from UAB

Imagine that we have an unlimited number of congruent equilateral triangles. We define a trapezoid number as the number of equilateral triangles used to tile a trapezoid. Similarly, we define a parallelogram number as the number of equilateral triangles needed to tile a parallelogram. We define the multiplicity of a trapezoid or parallelogram number as the number of ways we can construct the polygon for given number up to congruence. We show a parallelogram number can always be written as 2kh and a trapezoid number as h(2k + h), where we define the height h as the length of the …

The Effect Of Laser-Plasma Conditions In Ss-Fese Epitaxy By Pulsed Laser Deposition, Kamron Strickland

All ETDs from UAB

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Dr. Susie Weems Wheeler: A Narrative Case Study Of A Philanthropic Educator During The Civil Rights Era, Alisha D. Wheeler

All ETDs from UAB

The purpose of this narrative case study was to explore the life experiences and contributions of Dr. Susie Weems Wheeler (1917- 2007), a pioneer African American early childhood educator and administrator during and after the Civil Rights Era. There is limited research on Dr. Wheeler’s life and other African American women who were pioneers in Early Childhood Education during the Civil Rights Era. This study is significant because it focused on the contributions of a pioneer who is missing from the available literature. Data was collected using interviews and review historical documents. The researcher implemented thematic analysis and restorying to …

Pueraria Candollei Var. Mirifica: A Precious Source Of Pharmaceuticals And Cosmeceuticals, Dolly Rani, Khwanlada Kobtrakul, Sornkanok Vimolmangkang

The Thai Journal of Pharmaceutical Sciences

Pueraria candollei var. mirifica (Airy Shaw & Suvat.) Niyomdham (PM), popularly known as “Kwao Krua,” is a medicinal plant that has been used for centuries in Thailand. Phytochemical studies indicated the presence of several bioactive molecules such as miroestrol, deoxymiroestrol, puerarin, daidzein, daidzin, genistin, genistein, and kwakhurin. The pharmacological evaluation of PM indicated strong estrogenic, anti-osteoporosis effects, anti-aging and antioxidant activities, as well as the ability to relieve other climacteric-related symptoms. There is conflicting evidence on the safety and toxicity of PM. The active ingredients in PM make it an ideal candidate for large-scale pharmaceutical exploitation as a cosmeceutical. Further …

Study On Post Approval Source Change Of Active Pharmaceutical Ingredient In The Finished Product And Its Regulatory Requirements In Eu And Us, Kalpana Kamnoore, M. P. Venkatesh, T.M. Pramod Kumar

The Thai Journal of Pharmaceutical Sciences

Post approval changes are changes to any characteristic of pharmaceutical product after approval. Certificate of suitability of European pharmacopoeia (CEP) and drug master file (DMF) are two mechanisms for active pharmaceutical ingredient (API) registration. Regulatory requirements vary for each mechanism. This study focused on regulatory requirements for post approval API source change in the European Union (EU) and USA; and to delve on the mechanism of post approval API source changes in the USA and EU. To improve quality of the API, the most of the pharmaceutical industries concentrate on CEP certified source instead of DMF as CEP assures compliance …

Cytotoxic Effect Of Crude Vitex Glabrata Fruit Extracts On Human Cancer Cell Lines, Saraphorn Intarasam, Vorranuch Keerathinant, Mesayamas Kongsema, Kantimanee Pradermwong

The Thai Journal of Pharmaceutical Sciences

Vitex glabrata (VG) or Khai-noa fruit extracts were prepared from three methods; squeezing extract (SE), maceration extract (ME), and ethanol extraction (EE) to evaluate their effects in vitro. By the (1,1-diphenyl-2-picrylhydrazyl) scavenging assay, all extracts revealed very weak antioxidant. Results of (3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide, a tetrazole) assay showed the increase in cell viability of SE at 100 and 500 μg/ml on TK6 cells after 24 and 48 h treatments (P < 0.01) without affecting Caco-2 cells. Conversely, a dose- and time-dependent cytotoxicity of all extracts revealed at 1000-2000 μg/ml on both cells (P < 0.01). SE showed cytotoxicity on PC-3 cells and anticancer activity when confirmed by clonogenic assay in a dose-dependent manner. SE also showed cytotoxicity on HT-29 cells after 24 h treatment but the cells could recurrent in the clonogenic assay. No effect was observed on MCF-7 cells after SE alone, SE co-treated with MMC treatment, and in the clonogenic assay. Moreover, HT-29 cells revealed a dose-dependent decrease in viability when treated with SE co-treated with MMC by 24 h. Hence, SE can selectively promote cell viability on TK6 and anticancer activity on PC-3. These results suggest that the different potential of SE depends on different cell lines.

In Situ Hyaluronic Acid-Based Hydrogel Incorporated With Insulin-Like Growth Factor-1 For Three-Dimensional Encapsulation Of Keratinocytes, Pornsuda Lengwan, Pithi Chanvorachote

The Thai Journal of Pharmaceutical Sciences

Background/Aim: This work aimed to establish in situ hydrogel formation based on crosslinking of methacrylated hyaluronic acid (MeHA) and the polymer incorporated with insulin-like growth factor 1 (IGF-1) for keratinocyte three-dimension (3D) culture. Materials and Methods: The compatibility of human keratinocytes with developed hydrogel was determined by PrestoBlueTM cell viability assay. The live and dead cells were determined by Calcein AM, Propidium Iodide and Hoechst 33342 staining. The physical properties including gelation time, microstructure (porosity and interconnectivity), swelling ratio, and stability of the different concentration hydrogel were determined and correlated to cell viability. Results: Three percent w/v MeHA for in …

Formulation, Ex-Vivo And In-Vitro Characterization Of Liposomal Drug Delivery System Of Fexofenadine, Safin Shrestha, Uttam Budhathoki

The Thai Journal of Pharmaceutical Sciences

In order to improve the low permeability associated with conventional or immediate release dosage forms such as nasal spray and oral solid dosage form, tablets, fexofenadine liposomes were prepared by using ethanol injection method by varying the concentration of surfactant, (Tween -80), along with crude lecithin and cholesterol. The optimized formulations was evaluated for size, shape, entrapment efficiency and in vitro drug release. In this study the optimized formulated liposomes appeared to be spherical in shape and particle size was found to be 4703.667±445 nm. There is 1.25 times more flux of liposome as compared with free drug. The entrapment …

Behavior Of Polymers And In-Vitro Evaluation On Gastroretentive Nifedipine Sustained Release Floating Tablets, H. K. Pradeep, Juturu Thimmasetty, P.R. Sathesh Babu, S. Gururaj, N. Sreeharsha

The Thai Journal of Pharmaceutical Sciences

Nifedipine is one of the calcium channel blockers widely employed in indications such as high blood pressure and angina pectoris. In the present study, a prompt attempt is done in the formulation of gastro retentive sustained-release tablets. The effect of polymers and their combination on release pattern, initial burst release, and floating behavior were studied. Out of four polymers, two polymers such as cellulose derivatives like highly viscous polymer Hydroxypropyl methylcellulose (HPMC) K100, low viscous HPMC K4M and their combinations, and other two polymers used were from natural sources like xantham gum, guar gum and their combinations were studied. The …

Acute And Sub-Acute Toxicity Profile Of Methanol Leaf Extract Of Geophila Obvallata On Renal And Hepatic Indices In Wistar Rats, Osafanme Lucky Iserhienrhien, Paulinus Ngozi Okolie

The Thai Journal of Pharmaceutical Sciences

Introduction: Geophila obvallata (Rubiaceae) is a medicinal herb used for the treatment of diseases associated with oxidative damage. Objective: The study investigated the toxic effects of acute and sub-acute oral doses of methanol extracts of G. obvallata (GOE) in rats. Materials and Methods: In acute toxicity study, extract doses of 1600, 2900, and 5000 mg/kg were orally administered. The rats were observed for signs of toxicity for 2 weeks. In sub-acute toxicity study, the extract was administered to rats at doses of 100, 500, and 1000 mg/kg for 28 days, while control rats received only water. At the end of …

Efavirenz Listed In The World Health Organization Prequalification Program: A Successful Case Study Of A Public Private Collaboration For Technology Transfer In Pharmaceutical Production And Quality Control In Thailand, Yupadee Sirisinsuk, Mukdavan Prakobvaitayakit, Nusaraporn Kessomboon, Usawadee Sutapuk, Kannikar Kijtiwatchakul, Noppawan Angkulsansanee

The Thai Journal of Pharmaceutical Sciences

Pharmaceutical technology transfer is an important tool for enhancing production development and quality control. The Government Pharmaceutical Organization (GPO) is the state enterprises under the Ministry of Public Health, whose main mission is to produce high quality medicines with reasonable price to increase accessibility to the Thai people. GPO has received the technology transfer from an overseas pharmaceutical company for the successful production of the efavirenz 600 mg tablet that was certified by the WHO Prequalification Program. The research objective was to study how this success has been achieved with the support of technology transference as well as the relevant …

A Review On Ethnomedicinal And Phytopharmacological Potential Of Traditionally Wild And Endemic Plant Berberis Tinctoria Lesch., Arumugam Vignesh, Ramamoorthy Sivalingam, Subramaniam Selvakumar, Krishnan Vasanth

The Thai Journal of Pharmaceutical Sciences

Introduction: Berberis tinctoria an evergreen shrub, endemic and predominantly found at a higher altitude of the Nilgiri Biosphere Reserve, India. This leaf and fruit are edible, which are also used in homeopathic remedies for countless illnesses. Objectives: B. tinctoria with diverse ethnomedicinal uses was focused in the prevailing study to detailed the phytochemical and pharmacological properties for further imminent research in this species. Materials and methods: Published data in this review were all gathered from the online bibliographical databases: PubMed, Elsevier, Scopus, Google Scholar, Web of Science, and local ethnic community peoples of Kurumba and Toda. Results: B. tinctoria was …

Gastroprotective Effect Of Phyllanthus Reticulatus Poir. Against Pylorus Ligation-, Ethanol-Induced, And Stress-Induced Ulcer Models In Wistar Rats, Saravanan Jayaram, G. Thamotharan, N. Senthilkumar

The Thai Journal of Pharmaceutical Sciences

Objective: The objective of the present study is to evaluate the antiulcer property of ethanolic extract of Phyllanthus reticulatus Poir. against pylorus ligation-, ethanol-induced, and stress-induced ulcer models in Wistar albino rats. Materials and Methods: Three models – pylorus ligation-induced ulcer, ethanol-induced ulcer, and swim stress-induced ulcer – were used to induce ulcer in Wistar rats. The animals were treated with 200 mg/kg and 400 mg/kg p. o of the ethanolic extract of P. reticulatus Poir, to estimate the gastroprotective potential. The effect of P. reticulatus Poir. on pH of the gastric juice, volume of acid secretion, total and free …

Synthesis And Cytotoxic Activity Of N-(2,4-Dichloro)Benzoyl-N’-Phenylthiourea Against Human Breast Cancer Cell Line, Dini Kesuma, Anwar Medika, Tegar Achsendo Yuniarta

The Thai Journal of Pharmaceutical Sciences

Introduction: Urea- and thiourea-based compound has shown a potency to be further developed as anticancer compound. Objective: Another novel phenylthiourea analog (N-(2,4-dichloro)benzoyl-N’-phenylthiourea) was synthesized through Schotten-Baumann reaction followed by the assessment of its cytotoxic activity. Methods: N-(2,4-dichloro)benzoyl-N’-phenylthiourea was synthesized using N-Phenylthiourea and 2,4-dichlorobenzoyl chloride as starting materials. The reaction started at low temperature for 30 min followed by reflux for 8 h to yield target compound. Cytotoxicity assay was then performed against MCF-7, T47D, and Vero normal cell line. Results: The compound has been synthesized and its structure has been verified using infrared, 1H-nuclear magnetic resonance (NMR), 13C-NMR, various 2D …

Job Scheduling For Stability Testing Of Pharmaceutical Products Using Mathematical Model, Kantanat Pridaphatrakun, Nuchanad Bunkerd, Netnawee Umin, Narueporn Sutanthavibul, Wipawee Tharmmaphornphilas, Phanphen Wattanaarsakit

The Thai Journal of Pharmaceutical Sciences

The pharmaceutical industry plays an important role in the nation’s economy and society since pharmaceutical products are one of the factors that affect people’s lives and their health. At present, the domestic pharmaceutical industry is developing and adapting to meet the needs of customers and is also very competitive. Therefore, each stage of the production process must be as efficient as possible to achieve competitive advantages without compromising the product quality. One important process in production is pharmaceutical product stability testing, which ensures that the products have the necessary quality, efficacy, and safety. Managing time in a way that maximizes …

Review On Drug Delivery Applications Of Ethosomes: Current Developments And Prospects, Mayuri Shitole, Sopan Nangare, Udaykumar Patil, Namdeo R. Jadhav

The Thai Journal of Pharmaceutical Sciences

Transdermal drug delivery system networks are primarily affected by poor penetration of therapeutically active compounds. The stratum corneum (SC) is the foremost barrier of the skin, which restricts the permeation of the drug molecule. In this context, to date, numerous approaches have been implemented to overcome the SC barrier limitations. Out of this, few advanced approaches including liposomes, niosomes, ethosomes, and transferosomes are majorly used to boost the permeation of drug and cosmetic agents across the SC barrier. Among these vesicles, ethosomes are stand out as the best substitute for topical drug delivery. In a nutshell, ethosomes are the elastic …

Amelioration Of Cadmium Chloride Testicular Toxicity By Plukenetia Conophora Aqueous Leaves Extract In Wistar Rats, Tomilola Olaolu, Tamaratare Ogu, Damilare Rotimi, Charles Nwonuma, Oluwakemi Awakan, Ayotunde Olaolu, Akpor Oghenerobor

The Thai Journal of Pharmaceutical Sciences

Cadmium accumulates in different organ and tissues of the body including the testes, impeding normal metabolism. This study aimed at evaluating the effect of Plukenetia conophora leaves extract on antioxidants and testicular function indices of cadmium chloride (CdCl2)-administered Wistar rats. A total of 25 Wistar rats (100–120 g) were randomly divided into 5 groups (A-E) and received orally, once daily for 21 d as follows: A (distilled water); B (6.5 mg/kg body weight of CdCl2; C (CdCl2 + 150 mg/kg body weight of extract); D (CdCl2 + 300 mg/kg body weight extract); and E (CdCl2 + 600 mg/kg body weight …

Analytical Method For Simultaneous Estimation Of Ranolazine And Metformin Hydrochloride By Validated Rp-Hplc-Dad Method, Ashok B. Patel, Dhruvanshi A. Gol, Rahul L. Makwana, Amitkumar J. Vyas, Ajay I. Patel, Nilesh K. Patel, Shital D. Faldu, Arvind N. Lumbhani

The Thai Journal of Pharmaceutical Sciences

Background: In the present study, a simple, sensitive, rapid, accurate, and precise reverse-phase high-performance liquid chromatography (RP-HPLC) method with diode array detection was developed and validated for simultaneous estimation of Metformin hydrochloride (MET) and Ranolazine (RANO) in a synthetic mixture. Material and Method: The method was developed using isocratic elution mode on a reversed-phase. Chromatographic separation was performed on ACE CN C18 (250 mm, 4.5 mm, 5 μm) column and a mobile phase consisting of methanol: acetonitrile:ammonium formate (45:45:10% v/v/v) with 10% formic acid to adjust the pH to 6.0, at a flow rate of 1.0 ml/min. Detection and quantification …

Preparation And Characterization Of Curcumin-Loaded Liposomes For Delivery To The Lungs, Safura Binti Mohd Mohari, Kevin M. G. Taylor, Nattika Nimmano

The Thai Journal of Pharmaceutical Sciences

Curcumin-loaded liposomes comprising dipalmitoylphosphatidylcholine, cholesterol, and dioleoylphosphatidylethanolamine (72:8:20 mole ratio) were prepared by the thin-film hydration method, followed by probe sonication to achieve a mean diameter (FSI) pre-cooled at 2–8°C for at least 90 min at 15 L/min. Curcumin recovered from the impactor and nebulizer was quantified using a validated high-performance liquid chromatography method. Overall, 2.5% w/w curcumin-loaded liposomes was the optimal formulation based on the maximum encapsulation efficiency of approximately 87% and mean hydrodynamic diameter of 97 nm. This chosen curcumin concentration was effectively aerosolized with a fine particle fraction of 53.25%, and a fine particle dose of 53 …

Phytochemical Screening And Potential Anticonvulsant Activity Of Aqueous Root Extract Of Decalepis Nervosa Wight & Arn., Kuntal Das, M. Saifulla Khan, A. Muthukumar, Sayani Bhattacharyya, M. Usha, S. Venkatesh, James Sounder

The Thai Journal of Pharmaceutical Sciences

The effect of phytochemicals in the aqueous root extracts of Decalepis nervosa Wight & Arn. (ARDN) (Family: Apocynaceae) was investigated on an anticonvulsant action in laboratory animals (mice). The DN roots were extracted using microwave extraction method with aqueous solvent using two parameters, such as temperature variation and extraction time. The phytochemical screening followed by thin-layer chromatography (TLC) and high-performance thin-layer chromatography (HPTLC) studies was performed. The pentylenetetrazole and isoniazid models were used with two doses, 250 mg and 500 mg, for the anticonvulsant effects of the ARDN extract. The microwave extraction during 15 min at 60°C temperature revealed the …

Development Of A Notification System For Intravenous-To-Oral Antibiotic Switch Therapy In Pediatric Wards Using Value Stream Mapping, Nissara Srisura, Nusaraporn Kessomboon, Ancharee Leechaipichikul, Thawatchai Khummuang

The Thai Journal of Pharmaceutical Sciences

Objective: This research developed a notification intravenous-to-oral antibiotic switch therapy system using value stream mapping (VSM) through the Plan-Do-Study-Act (PDSA) method. Materials and Methods: The action research took place in two target groups: Group 1 included a multidisciplinary team and Group 2 included pneumonia patients admitted to two pediatric wards. The system had two phases: In Phase I, Situation analysis reviewed 400 medical records and In Phase II, a system was developed that used PDSA as follows: Plan: analysis of the methods. Do: The demonstrated process used VSM. Study: A system designed. Act: Comparing each step used VSM. The system …

Antibacterial Activity Of Ethanol Extract Of Asam Gelugur (Garcinia Atroviridis) Fruits From Southern Thailand, Atchara Niyomdecha, Chaiyawan Wattanachant, Jessada Rattanawut, Patimaporn Plodpai, Wanwisa Ngampongsai

The Thai Journal of Pharmaceutical Sciences

Objective: The present study investigated the antibacterial activities of asam gelugur (Garcinia atroviridis) fruit extracts against two Gram-negative bacterial strains (Escherichia coli (gi: CP033762.1) and Salmonella enterica (gi: KX355299.1)). Materials and Methods: The powder form of G. atroviridis fresh fruit was extracted with 95% ethanol (2:4 L) (w/v). The mixtures were filtered and evaporated using a rotary evaporator at 50–55°C. High-performance liquid chromatography (HPLC) was used to measure hydroxycitric acid (HCA) in the extract. The antibacterial assay was determined by disk diffusion method, the minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC). Results: HPLC analysis measured approximately 495.01 ± …

Ccit Report 2022, Critical Creative Innovative Thinking

Critical Creative Innovative Thinking (CCIT) Archives

Content

• About us
• Incubation
• National Health Incubation Program (2021-2022)
• what we do
• System Innovation
• Research & Communication
• Our path in Education
• 2023: onwards & upwards

Nutrition Practices And Body Composition In Infants Born Preterm, Maggie Jerome

All ETDs from UAB

Adequate nutrition and optimal growth are critical goals of clinical care for premature infants in the NICU due to rapid brain growth and development that occur during this time. Emerging evidence suggests that body composition in preterm infants is predictive of neurodevelopmental and metabolic outcomes later in childhood. The objective of this dissertation is to investigate factors affecting premature infant growth and body composition, including high enteral protein supplementation, nutrition during the first two weeks of life, and race of infants born at 22-32 weeks gestational age admitted to the UAB NICU. In a pilot study, 56 preterm infants were …

Cell Type-Specific Diurnal Variation In Hippocampus Physiology, Lacy Kathryn Goode

All ETDs from UAB

Circadian rhythms are biological processes that cycle across 24 hours. Driven endogenously by widely expressed and highly conserved clock genes that compose the circadian molecular clock, circadian rhythms are exhibited in numerous facets of physiology across nearly every tissue throughout the body. Diurnal rhythms in cognition, long-term potentiation (LTP), and the expression of clock genes in hippocampus subfields support a role for circadian regulation of hippocampus physiology. However, little is known regarding the circadian molecular clock and diurnal rhythms in neurophysiology at the cellular level. Here, we characterized diurnal differences in spatial memory, LTP, excitability of and synaptic transmission onto …

Exploring The Influence Of Psychosocial Stress And Inflammatory Properties Of The Diet On Cardiometabolic Risk And Gut Microbiome Health Among Young Adult Women Of Birmingham, Alabama, Rachel Olivia Knight

All ETDs from UAB

Concerning trends for obesity, diabetes, heart attacks, and obesity-related cancers, or cardiometabolic disease (CMD), are developing within the emerging and young adult/adulthood (EYA) population. Evidence supports the concept that chronic stress leads to physiologic dysregulation, reduced mental health, chronic diseases, and reduced longevity; however, these are not inevitable outcomes, and resilience or vulnerability is determined by interacting environmental and biobehavioral factors. Although CMD manifests clinically in older adulthood, disease pathophysiology begins earlier, and thus, EYA is a critical time for observation and intervention. Growing evidence indicates inflammation is a major risk factor in CMD development and may be exacerbated by …

Intrinsically-Photosensitive Retinal Ganglion Cells And Their Functional Roles, Kevin Q. Chang

All ETDs from UAB

This project was conducted in Old World monkeys and focused on characterization of the intrinsically photosensitive retinal ganglion cells (ipRGCs) as they pertain to the pupillary light reflex, as well as on the neuroanatomical and electrophysiological characterization of the suprachiasmatic nucleus (SCN) of the hypothalamus as it pertains to circadian rhythms. A custom antibody was developed against the human melanopsin gene. We validated the antibody using western blot and immunohistochemistry. The functional role of ipRGCs in driving pupillary responses was investigated through immunotoxin-induced ablation in Rhesus macaques with the antibody conjugated to saporin. As hypothesized, the pupillary light reflex and …

Longitudinal Investigation Of Financial Capacity And Driving Performance In Mild Cognitive Impairment, Tyler P. Bull

All ETDs from UAB

Previous research has shown that Mild Cognitive Impairment (MCI) is an intermediary between normal aging and dementia that is associated with declines in financial capacity and driving performance, two important instrumental activities of daily living (IADLs). Both financial capacity and driving performance have been studied cross-sectionally within an MCI population, but there is limited information on the changes in performance over time. The present study utilized data from a recent longitudinal clinical trial of speed of processing training to further examine changes in driving performance and financial capacity over time. Participants included seventy-five older adults with MCI who completed an …

Participation And Perceptions Of Resistance Training In Former Female High School Athletes, Craig Heuring

Master of Education in Applied Human Development Graduate Projects

Resistance training (RT) has been shown to better prepare athletes for the physical demands of their sport. However, former female high school athletes’ participation rates and perceptions of RT are unknown. The aim of this study was to identify key factors and themes influencing participation and perceptions of RT in this population. Former female high school athletes (n=73) between the ages of 18-24 years old completed an electronic questionnaire-based survey. The survey included a RT questionnaire and background questions regarding each participant’s high school athletic environment. We examined responses to identify how high school athletic environments may influence …