Digital Commons Network^™

Mapping Health Research Involving Human Subjects In Saudi Arabia: A Text Mining And Topic Modeling Analysis, Khalid A. Alhussain

Saudi Medical Journal

Objectives: To identify dominant and underrepresented research topics and to classify published studies by design and data sources in health research involving human subjects from Saudi Arabia. Methods: This retrospective study analyzed PubMed-indexed health articles related to Saudi Arabia from 1959 to March 2025. Text mining was used to identify studies conducted in the country involving human subjects. Eligible articles were classified by study design and data sources. Topic modeling using non-negative matrix factorization was applied to identify topics based on the primary research focus. Results: A total of 36,452 records of studies conducted in Saudi Arabia were initially identified. …

Translational Barriers To Aav And Crispr Gene Therapy In Diabetes, Abdulrahman G. Alharbi

Saudi Medical Journal

Gene therapy targets diabetes pathophysiology rather than symptoms, yet clinical translation is slower than preclinical success. This review synthesizes 143 registered trials (ClinicalTrials.gov, 2010-2025) identifying systematic implementation barriers. Despite >15 years of development, 83% of trials remain in Phase I-II. Only zimislecel achieved Phase III outcomes (83% insulin independence at 12 months, n=12, requiring immunosuppression). VM202 for diabetic neuropathy failed Phase III despite positive extension results. Three systematic barriers emerged: (1) human transduction efficiency is 6-8.7-fold lower than preclinical models; (2) pre-existing immunity excludes 58-78% of candidates; (3) manufacturing capacity serves <2.5% of target population (40-400 years to treat at maximum capacity). These constraints explain why ex vivo cell therapies advanced to efficacy trials while in vivo gene delivery remains in Phase I despite longer development timelines. Research priorities should emphasize non-viral delivery systems offering scalable manufacturing and universal hypoimmune donor cells to address access barriers.

Semaglutide In Metabolic Medicine: A Review On Clinical Applications And Emerging Therapeutics, Abdulrahman A. Aljabri

Saudi Medical Journal

Obesity and type 2 diabetes mellitus affect over 800 million and 537 million individuals worldwide. Semaglutide, a weekly glucagon-like peptide-1 receptor agonist, has advanced treatment of pathophysiological processes linked to metabolic dysregulation. This review consolidates evidence on its mechanisms of action, clinical effectiveness across established and emerging applications, safety, and prospects for personalized therapy. Clinical studies have shown that semaglutide sustains glycemic control, promotes substantial weight loss, and provides cardiovascular and renal protection. Recent FDA clearance marks the first therapeutic alternative for metabolic dysfunction-associated steatohepatitis among the emerging applications. Pharmacogenomic insights facilitate personalized therapy; however, clinical applications remain in experimental …

Rehabilitation Outcomes Of Pediatric Burn Survivors In Saudi Arabia: A Thematic Narrative Review And Policy Implications, Abdulaziz Ghandurah, Mshari Alghadier

Saudi Medical Journal

Pediatric burns in Saudi Arabia are predominantly household scalds in young children, causing long-term disability from scarring, contractures, pain/itch, psychosocial distress, and disrupted schooling. This thematic narrative review (2010–2025) synthesizes global and regional evidence, appraises outcome measures with attention to Arabic availability, and translates findings into Vision 2030–aligned policy actions. Evidence supports early, multidisciplinary care anchored in standardized outcome tracking. Pressure-garment therapy remains inconclusive, whereas virtual reality reduces procedural pain and telerehabilitation serves families distant from tertiary centers. A minimum national outcome set is proposed spanning scar quality (VSS, POSAS), joint range of motion, age-appropriate pain and itch scales (FLACC/FPS-R/NRS), …

Understanding The Cost Consequences Of Pharmacist Roles In Managing Long-Term Illnesses: A Systematic Review, Muhammad Zahid Iqbal

Saudi Medical Journal

Objective: This review looked at how different pharmacist-led services influence medication spending and other economic outcomes for people living with long-term illnesses. Methods: To gather the evidence, we followed the PRISMA 2020 approach and a comprehensive search was conducted using multiple sources, including Web of Science, ProQuest, Scopus, the Directory of Open Access Journals, ScienceDirect, PubMed, and Google Scholar. We included studies that examined pharmacist involvement in medication management such as MTM, medication reconciliation, deprescribing efforts, or full medication reviews and that reported some form of cost or economic outcome in chronic disease care. We left out non-English work, conference …

Impact Of Clinical Pharmacist Educational Intervention On Lipid Profile And Its Clinical Outcomes, Saad Saeed Alqahtani

Saudi Medical Journal

Objective: To assess how clinical pharmacist-led educational interventions affect lipid profile parameters and related clinical outcomes in cardiovascular disease-risk individuals. Methods: This systematic review completed as according to PRISMA 2020 principles. Searches were done on PubMed, ScienceDirect, ProQuest, Google Scholar, DOAJ, Scopus, and Web of Science. Studies examining impact of the pharmacists' educational initiatives on lipid levels were included. However, case reports, conference proceedings, and studies in other languages not in English, and studies lacking full-text access were excluded from the review. Following screening and eligibility assessment, a total of 33 papers were included out of the 1731 records found. …

A Multi-Task Cnn-Lstm Model With Attention Mechanism For Climate Temperature Forecasting Over Iraq, Salim M. Mohammed, Omar M. Mustafa, Lailan M. Haji, Omar M. Ahmed

Al-Bahir

Accurate forecasting of climate temperature at the regional scale is crucial to agriculture planning, water resource management, and disaster preparedness. Still, due to the nonlinear and complicated temporal patterns in regions such as Iraq, conventional climate models fail to meet this imperative. This paper presents a novel deep learning model that not only predicts monthly average temperature values but also predicts the temperature trend, hence addressing the regional climate prediction problem holistically. The proposed model is designed as a multi-task deep learning framework integrating Convolutional Neural Networks, Long Short-Term Memory networks, and an attention mechanism to process historical monthly temperature …

Health Effects Of Cadmium And Manganese Exposure On Luteinizing Hormone Levels: A Pilot Study Of Female Infertility, Shatha F. Alhous, Anees A. Al-Hamzawi, Murtadha Sh. Aswood

Al-Bahir

Female infertility occurs for many reasons, some unknown. Exposure to heavy metals is a risk factor that negatively impacts on female reproductive system. Therefore, this study aimed to evaluate the effect of cadmium Cd and manganese Mn on luteinizing hormone LH levels for females’ infertility. This study included a healthy group (n = 20), primary infertile females (n = 40), and secondary infertile females (n = 20) collected from Al-Zahraa hospital in Najaf center, Iraq. The Atomic Absorption Spectroscopy (AAS) was used to measure the cadmium and manganese concentrations and LH levels were measured by a Maglumi 800 from Snibe …

Enhanced Cuckoo Search-Based Optimization For Single Distributed Generation Placement And Sizing In Radial Distribution Systems, Samson Oladayo Ayanlade, Abdulrasaq Jimoh, Richard Oladayo Olarewaju, Ignatius Kema Okakwu, Israel O. Adejumobi, Joseph B. Samson, Oluwadare A. Adebisi, Oluwadare O. Akinrogunde

Al-Bahir

This paper presents an Enhanced Cuckoo Search Algorithm (ECSA) to optimally place and size Distributed Generation (DG) in radial distribution systems to minimize real power loss within operating constraints. The proposed ECSA has exponentially decaying adaptive Lévy flights, constraint-aware solution repair with dynamic penalty coefficients, and diversity-directed stochastic replacement to enhance search robustness and convergence speed. It was tested with 30 independent runs on the IEEE 33-bus, IEEE 69-bus, and a practical Nigerian 32-bus distribution network. The simulations show that the ECSA lowers the active power loss of the IEEE 33-bus system from 201.58 kW to 102.75 kW (49.03%), and …

Voltage-Mode Driver With Sar-Based Termination Calibration, Moustafa M. Elsayed, Abeer T. Khalil, Sameh A. Ibrahim, Mohy Eldin A. Abo-Elsoud

Mansoura Engineering Journal

This paper introduces a DAC-based four-level pulse-amplitude modulation (PAM-4) driver capable of operating at data rates up to 80 Gb/s in 65-nm CMOS technology. A replica-based termination calibration loop is proposed to preserve driver linearity across process, voltage, and temperature (PVT) variations. The proposed driver achieves a relative level mismatch (RLM) of 99.3%. In addition, the transmitter demonstrates a vertical eye opening of 134.8 mV and a horizontal eye opening of 0.44 UI under worst-case conditions.

From Flat To Form, Madeline N. Henderson

SPARK Symposium Presentations

This dress design features a halter neckline with both side and neckline darts, creating a structured and well-fitted bodice. The pattern is developed using the Slashing technique, in which the waist dart of the basic bodice is transferred to the side and neckline by closing the original dart. The skirt is further enhanced with safety pins placed along the sides as a design embellishment. This combination of technical construction and bold detailing creates a cohesive garment that balances structure with an edgy aesthetic.

A Prosecutor’S Ethical Duty To Divert, Jordan Stevenson

Legal Writing Competition Winners

In an American courtroom, litigants are divided across an aisle, a gavel grants or divests rights, and a community takes sides. This creates a narrative of duality in the justice system, which many believe is vital to the adversarial legal system. A criminal trial is seen as perpetrator versus victim, but the legal posture is actually government versus individual. In fact, a prosecuting attorney has ethical obligations not just to victims, witnesses, and the broader community, but to defendants as well, in part due to their tremendous discretion to bring or dismiss criminal charges. A prosecutor’s power is far too …

Ethnic Studies March Newsletter, Department Of Ethnic Studies

Ethnic Studies Department Newsletters

Events, Student spotlight

Cardozo Law News Brief: March 20, 2026, Benjamin N. Cardozo School Of Law

Cardozo Law News Briefs

Highlights from the March 20, 2026, Cardozo Law News Brief include:

• Professor Monroe Price, former dean of Cardozo Law and a distinguished scholar, passed away at age 87, remembered for his decades of leadership, mentorship, and contributions to the law school community.
• Professor Lindsay Nash spoke to the Houston Chronicle about local police coordinating with ICE, noting ongoing legal challenges surrounding immigration enforcement.
• Professor Wilfred Codrington III was quoted in Bloomberg Law on the selection of a new leader for the American Constitution Society.
• Professor Tyson-Lord Gray spoke to USA Today about SNAP policy, explaining longstanding federal limits on …

Library Newsletter: Mid March ‘26, Iwasaki Library

Iwasaki Newsletters

This Library Newsletter reached faculty, staff, and students of Emerson College on March 20th, 2026. This is the only published issue of March 2026. This is the eleventh issue of the third volume. It includes top stories such as volunteering at Relaxapalooza, Emerson Alum Kelsey Day (‘21) celebrates book release at the Library, WasteNot Emerson, building a Community Archive Project, an EBONI display, and librarians assisting with final projects.

Clinical Prediction Of Posttreatment Migraine Recurrence Using Biofeedback Data: A Machine Learning Framework For Enhanced Patient Stratification And Treatment Monitoring, Shibbir Ahmed Arif, Ferdib-Al-Islam, Mehidy Hasan Sium

School of Computing Faculty Scholarship and Creative Works

Migraine is a complex neurological disorder with significant implications for individual well-being and public health. Predicting migraine occurrences after treatment is crucial for evaluating therapeutic efficacy and enabling personalized care, yet remains largely underexplored. This study proposes a robust machine learning framework to predict posttreatment migraine headache occurrences using real-world headache log data collected from 133 patients undergoing biofeedback therapy. The methodology includes rigorous data preprocessing, outlier removal via the interquartile range (IQR) method, and class imbalance correction through the synthetic minority oversampling technique (SMOTE). A total of 10 classical and a hybrid ensemble machine learning models were developed and …

Sga 57 Senate 2026-03-20 Agenda, Niu Student Government Association Senate

Student Government Association Archives

No abstract provided.

Sga 57 Senate 2026-03-20 Minutes, Niu Student Government Association Senate

Student Government Association Archives

No abstract provided.

Tet2 Modulates Er Stress Responses Related To Β-Cell Death And Autoimmunity In Diabetes., Jinxiu Rui, Madhav Kothari, Romy Kursawe, Mahsa Nouri Barkestani, Romi Genosar, Pamela Clark, Michael L. Stitzel, Kevan C Herold

Faculty Research 2026

We found that beta cells from Tet2-deficient mice were protected from killing in a model of autoimmune Type 1 diabetes, but the mechanism of protection and specific cell types affected by Tet2 loss were unknown. Herein we show that in Tet2-deficient NOD mice transplanted with wild-type bone marrow, there are fewer islet infiltrating lymphocytes beginning 8–10 weeks after transplant, which was seen primarily among CD4⁺ T-cells. Transcription factor binding motifs for interferon responses factors and inflammatory signaling molecules were enriched in Tet2-responsive cis-regulatory elements across all KO islet endocrine cells, but we observed beta cell-specific enrichment …

Stimulation Of The Medial Septum Diagonal Band Of Broca Rescues Learning And Memory Deficits In, Mohamed Ouardouz, Amanda E Hernan, J Matthew Mahoney, Rodney C Scott

Faculty Research 2026

Fragile X Syndrome (FXS), the most common inherited cause of intellectual disability and a leading monogenic cause of autism, arises from the loss of Fragile X Messenger Ribonucleoprotein (Fmr protein), leading to synaptic and cognitive dysfunction. Here, we demonstrate that the frequency-specific electrical stimulation of the medial septum/diagonal band of Broca (MSDB) can restore cognitive and synaptic impairments in Fmr1 knockout mice, a validated model of FXS. Thirty minutes of 35 Hz MSDB stimulation significantly improved subsequent recognition memory, sociability, spatial learning, and fear memory, with recognition memory enhancements persisting for up to 7 days after daily 30 min …

Stimulation Of The Medial Septum Diagonal Band Of Broca Rescues Learning And Memory Deficits In Fmr1 Ko Mice, Mohamed Ouardouz, Amanda E Hernan, J. Matthew Mahoney, Rodney C Scott

SKMC Student Presentations and Publications

Fragile X Syndrome (FXS), the most common inherited cause of intellectual disability and a leading monogenic cause of autism, arises from the loss of Fragile X Messenger Ribonucleoprotein (Fmr protein), leading to synaptic and cognitive dysfunction. Here, we demonstrate that the frequency-specific electrical stimulation of the medial septum/diagonal band of Broca (MSDB) can restore cognitive and synaptic impairments in Fmr1 knockout mice, a validated model of FXS. Thirty minutes of 35 Hz MSDB stimulation significantly improved subsequent recognition memory, sociability, spatial learning, and fear memory, with recognition memory enhancements persisting for up to 7 days after daily 30 min …

Stephenson V. Lucenti

All Decisions

In a nonpayment proceeding involving an unregulated month-to-month tenancy, the Civil Court dismissed the landlord's petition due to the landlord's failure to appear. The landlord moved to vacate the dismissal, arguing excusable law office failure and a meritorious claim. The Civil Court denied the motion, citing a lack of a lease. The Appellate Term reversed, holding that counsel's mis-calendaring was a reasonable excuse and that a potentially meritorious claim for unpaid rent under an oral month-to-month agreement existed. The court granted the landlord's motion to vacate and reinstated the petition.

The Zircon, March 20, 2026 [Spoof Issue], Dordt University

Dordt Diamond

No abstract provided.

Science Challenges And Solutions To Support Implementation Of The Biodiversity Beyond National Jurisdiction Agreement, Claire L. Szostek, Angus Atkinson, Victor Martinez-Vicente, Ana M. Queirós, Peter I. Miller, Kerry L. Howell, Rebecca C. Millington, Susan Kay, Matthew Faith, Karen Tait, Elizabeth Talbot, Andrew Rees, Chris Lyal, Jeff Ardron, Matthew Frost

School of Biological and Marine Sciences

The Biodiversity Beyond National Jurisdiction (BBNJ) Agreement provides a new opportunity to consolidate and achieve global marine environmental goals. Here we focus on how science and technology will support its implementation. We provide an overview of existing scientific knowledge and methods that are scalable to Areas Beyond National Jurisdiction (ABNJ). Reviewing data gaps, challenges and opportunities, we outline solutions and a roadmap focused on enhancing resources and capacity.

Chemical Synthesis For Mesoporous Silica (Mcm-41) And Evaluating Its Efficiency In Removal Of Heavy Metals Ions, Israa M. Faliyh, Wahran M. Saod

Baghdad Science Journal

The pollution of water sources due to harmful chemicals, especially heavy metal ions such as Ni⁺⁺ and Co⁺⁺, remains a global challenge. To address this issue, various studies have focused on developing new treatment methods. Nanotechnology provides innovative techniques for efficiently removing heavy metals and other pollutants from water and wastewater. It is crucial to eliminate these hazardous heavy metals to protect both human health and the environment. Mesoporous silica (MCM-41) is a type of silica nanoparticles with pores ranging from 2 to 50 nm in diameter, and a total diameter below 1 μm. It is gaining …

Comparing The Levels Of Some Biochemical Markers In Rheumatoid Arthritis Patients With And Without Depression, Shnst Ibrahim Mohamed Ali, Israa Ghassan Zainal

Baghdad Science Journal

One of the most common comorbidities of rheumatoid arthritis is depression, which is an independent mood disorder. This study aims to examine the blood levels of some biochemical markers in rheumatoid arthritis patients with and without depression compared to healthy group. This study included three groups: rheumatoid arthritis patients with depression, rheumatoid arthritis patients without depression, and a healthy group. The results showed that patients groups had significantly (P ≤ 0.05) higher activity of acetylcholine esterase and ceruloplasmine, carbonyl, ischemic modified albumin (IMA), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α ), Haptoglobin, and Cupper, and significantly (P ≤ 0.05) …

Knockdown Of Tyrosine Kinase Receptor Fgfr1 Via Azd4547 Suppresses Breast Cancer Proliferation, Migration, And Invasion In Brca1 Mutant Adipose-Derived Stem Cells (Ascs) Via Il-6 And Tnf-Α Modulation, Nahid Sabah Aldin Saber, Zahraa Ali Mohammed

Baghdad Science Journal

Breast cancer is a complex heterogeneous disease that poses significant challenges in identifying novel therapeutic strategies and new therapeutic targets. Recent research has identified adipose-derived stem cells (ASCs) role in the progression of small tumors. Mutations in Breast Cancer gene 1 (BRCA1) are known to play a crucial role in DNA repair and cell cycle regulation. BRCA1 mutations have been associated with increased risks of breast and ovarian cancer. Moreover, studies have shown that Fibroblast Growth Factor Receptor 1 (FGFR1) is involved in initiation of many cancers, including breast cancer. In the present study, we aim to investigate the role …

Studying The Level Of Amyloid-A And Fibrinogen-Like Protein 1 And Other Biomarkers In The Sera Of Rheumatoid Arthritis Of Iraqi Patients, Aya Waleed Aziz, Bushra Faris Hasan

Baghdad Science Journal

Rheumatoid arthritis (RA) isa common chronic autoimmune disease characterized by synovitis causing pain and inflammation and can result in joint destruction, its risk factors involve a family history of disease, obesity, smoking as well as viral infections. In this study, serum amyloid A and fibrinogen-like protein 1 were evaluated in 80 patients and 40 healthy controls (both men and women). Measurement of SAA, FGL1, RF, CRP, and MPO were performed using ELISA kits, the colorimetric method has been employed for estimating lipid profile, and Westergren method has used to measure ESR. The results indicated that levels of SAA, FGL1, MPO, …

Determination Of Trace Pyridoxine Hydrochloride (Vitamin B6) In Dosage Forms And Redbull Samples Using Dispersive Liquid-Liquid Microextraction Technique Coupled With Spectrophotometry, Sally Ghanem Ahmed, Wijdan Shakir Khayoon

Baghdad Science Journal

This paper introduced a sensitive determination method measurement spectrophotometric coupled with dispersive liquid-liquid micro extraction based on charge transfer complex formation between pyridoxine hydrochloride and chloranil using alkaline buffer (pH = 10.5). After that, the extraction of charge transfer complex was conducted by injection a mixture of chloroform and acetone solvents followed by spectrophotometric measurement of tiny organic droplets at λ = 535 nm. The important parameters affecting the formation of the complex and efficiency of DLLME such as concentration of chloranil, volume and pH of buffer solution, reaction time and the optimum conditions of DLLME has been studied and …

First Record Of Keratitis Caused By Valkampfia In Iraq, Turkan K. Karyagdi

Baghdad Science Journal

Acanthamoeba is the most well-known causes amoebic keratitis. However, other free-living amoebas (FLA), such as Valkampfia, can also causes of keratitis. Twenty-two samples were collected from cases suspected of amoebic keratitis in Kirkuk Hospital to investigate the presence of Acanthamoeba . Cultivation process was carried out directly on non-nutrient agar (NNA) medium supported with killed Escherichia coli bacteria. Inverted and light microscope were used at 40X magnification to diagnose cultures growth .Only two samples showed positive growth on NNA medium. However, no any presence of Acanthamoeba was observed as were expected using polymerase chain reaction (PCR) which ampilified by …