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The Expression And Function Of Glutamate Aspartate Transporters In Bergmann Glia Are Decreased In Neuronal Nitric Oxide Synthase-Knockout Mice During Postnatal Development, Vasiliki Tellios, Matthew J.E. Maksoud, Wei Yang Lu

Neuroscience Institute Publications

Bergmann glia (BG) predominantly use glutamate/aspartate transporters (GLAST) for glutamate uptake in the cerebellum. Recently, nitric oxide (NO) treatment has been shown to upregulate GLAST function and increase glutamate uptake in vitro. We previously discovered that neuronal nitric oxide synthase knockout (nNOS−/−) mice displayed structural and functional neuronal abnormalities in the cerebellum during development, in addition to previously reported motor deficits. Although these developmental deficits have been identified in the nNOS−/− cerebellum, it is unknown whether BG morphology and GLAST expression are also affected in the absence of nNOS in vivo. This study is the first to characterize BG morphology …

Rev-Erbα Knockout Reduces Ethanol Consumption And Preference In Male And Female Mice, Yasmine Al-Sabagh, Hayley Hope Allyssa Thorpe, Bryan William Jenkins, Shahnaza Hamidullah, Malik Asfandyaar Talhat, Cara Beth Suggett, Cristine Joelle Reitz, Mina Rasouli, Tami Avril Martino, Jibran Younis Khokhar

Neuroscience Institute Publications

Alcohol use is a contributor in the premature deaths of approximately 3 million people annually. Among the risk factors for alcohol misuse is circadian rhythm disruption; however, this connection remains poorly understood. Inhibition of the circadian nuclear receptor REV-ERBα is known to disrupt molecular feedback loops integral to daily oscillations, and impact diurnal fluctuations in the expression of proteins required for reward-related neurotransmission. However, the role of REV-ERBα in alcohol and substance use-related phenotypes is unknown. Herein, we used a Rev-erbα knockout mouse line and ethanol two-bottle choice preference testing to show that disruption of Rev-erbα reduces ethanol preference in …

The Cbi-R Detects Early Behavioural Impairment In Genetic Frontotemporal Dementia, Annabel Nelson, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, Arabella Bouzigues, Caroline V. Greaves, Martina Bocchetta, David M. Cash, John C. Van Swieten, Lize Jiskoot, Fermin Moreno, Raquel Sanchez-Valle, Robert Laforce, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Barbara Borroni, Elizabeth Finger, Matthis Synofzik, Daniela Galimberti, Rik Vandenberghe, Alexandre De Mendonça, Chris R. Butler, Alexander Gerhard, Simon Ducharme, Isabelle Le Ber, Isabel Santana, Florence Pasquier, Johannes Levin

Neuroscience Institute Publications

Introduction: Behavioural dysfunction is a key feature of genetic frontotemporal dementia (FTD) but validated clinical scales measuring behaviour are lacking at present. Methods: We assessed behaviour using the revised version of the Cambridge Behavioural Inventory (CBI-R) in 733 participants from the Genetic FTD Initiative study: 466 mutation carriers (195 C9orf72, 76 MAPT, 195 GRN) and 267 non-mutation carriers (controls). All mutation carriers were stratified according to their global CDR plus NACC FTLD score into three groups: asymptomatic (CDR = 0), prodromal (CDR = 0.5) and symptomatic (CDR = 1+). Mixed-effects models adjusted for age, education, sex and family clustering were …

A Data-Driven Disease Progression Model Of Fluid Biomarkers In Genetic Frontotemporal Dementia, Emma L. Van Der Ende, Esther E. Bron, Jackie M. Poos, Lize C. Jiskoot, Jessica L. Panman, Janne M. Papma, Lieke H. Meeter, Elise G.P. Dopper, Carlo Wilke, Matthis Synofzik, Carolin Heller, Imogen J. Swift, Aitana Sogorb-Esteve, Arabella Bouzigues, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Caroline Graff, Robert Laforce, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, James B. Rowe, Alexandre De Mendoncą, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Christopher R. Butler

Neuroscience Institute Publications

Several CSF and blood biomarkers for genetic frontotemporal dementia have been proposed, including those reflecting neuroaxonal loss (neurofilament light chain and phosphorylated neurofilament heavy chain), synapse dysfunction [neuronal pentraxin 2 (NPTX2)], astrogliosis (glial fibrillary acidic protein) and complement activation (C1q, C3b). Determining the sequence in which biomarkers become abnormal over the course of disease could facilitate disease staging and help identify mutation carriers with prodromal or early-stage frontotemporal dementia, which is especially important as pharmaceutical trials emerge. We aimed to model the sequence of biomarker abnormalities in presymptomatic and symptomatic genetic frontotemporal dementia using cross-sectional data from the Genetic Frontotemporal …

18 F-Mk-6240 Tau-Pet In Genetic Frontotemporal Dementia, Jake P. Levy, Gleb Bezgin, Melissa Savard, Tharick A. Pascoal, Elizabeth Finger, Robert Laforce, Joshua A. Sonnen, Jean Paul Soucy, Serge Gauthier, Pedro Rosa-Neto, Simon Ducharme

Neuroscience Institute Publications

Tau is one of several proteins associated with frontotemporal dementia. While knowing which protein is causing a patient's disease is crucial, no biomarker currently exists for identifying tau in vivo in frontotemporal dementia. The objective of this study was to investigate the potential for the promising 18F-MK-6240 PET tracer to bind to tau in vivo in genetic frontotemporal dementia. We enrolled subjects with genetic frontotemporal dementia, who constitute an ideal population for testing because their pathology is already known based on their mutation. Ten participants (three with symptomatic P301L and R406W MAPT mutations expected to show tau binding, three with …

Education And The Pandemic: Engaging In Epistemic Humility To Question Assumptions, Institutions, And Knowledges, Prachi Srivastava, Prachi Srivastava

Education Publications

Education systems are the formal institutionalisations of the knowledges and values our societies privilege, who they privilege, how, and on what terms. They are imbued with assumptions. These assumptions inform how systems are structured. The pandemic has exposed existing global and local inequalities, non-binary dynamics of inclusion and exclusion, and dysfunctions of education systems. This paper argues that the global scale and severity of the education disruption challenges taken-for-granted distinctions that privilege systems of the ‘West’ as referential for ‘the Rest’. It argues that the existing overarching technicist knowledge regime is inadequate for recovery, and proposes an alternative approach.

Do Environmental Regulations Affect The Decision To Export?, Jevan Cherniwchan, Nouri Najjar

Business Publications

This paper investigates how a common form of environmental regulation—air quality standards—affects exporters. We develop a simple theoretical model to show how the design of these standards causes (i) some firms to stop exporting and (ii) a reduction in the export volumes of affected continuing exporters. We exploit quasi-experimental variation resulting from the design of Canadian air quality standards to test these predictions empirically. Our estimates confirm our model's predictions: we find that for the most affected manufacturers, regulation reduced export volumes by 32 percent and increased the likelihood plants stop exporting by 5 percentage points. (JEL D12, F14, F18, …

A Descriptive Study Of College Students’ Preferences Toward Rhetorical Devices In Advertisements, Rachel Beyer

Agricultural Economics and Agribusiness Undergraduate Honors Theses

Advertisements are specifically created to convince people of the importance to either buy a product or subscribe to an ideal. Companies are the primary users of advertisements, where advertisements are designed to increase profitability (Roberts, 2020). The advertising industry in America is quite large. Food is a diversified and competitive industry, this competition in the food industry causes companies to be dependent on consumer preference and knowledge (UC Davis Nutrition Department, 2020). With Generation Z on the rise, there should be an increased focus on their preferences and needs in all industries, including the food industry (Southgate, 2017). The purpose …

Supporting A T-Shaped Identity Through Professional Associations: A Graduate Student Perspective, Suthanit Wetcho, Rebeca Peacock, Okan Arslan

University Author Recognition Bibliography: 2022

T-shaped identity has been suggested as an effective way to help graduate students develop strong disciplinary expertise and breadth of knowledge. To cultivate this T-shaped identity, graduate students may benefit from participating in professional associations. These professional associations can help graduate students learn and develop through the community's numerous activities such as developing knowledge and skills, presenting and discussing research, learning across the standards, and stepping into leadership roles. This paper discusses three graduate students' viewpoints on their experiences on how engaging in professional organizations has helped shape their identities.

Evidence-Based Practice Guideline Development: Selection Of Local Anesthetics And The Additive Dexamethasone In Brachial Plexus Blocks, Alexandra Mcguire

Doctor of Nursing Practice Scholarly Projects

Brachial plexus blocks (BPB) are a type of regional anesthesia that inhibits the sensory and motor function of the upper extremity. The efficacy of a BPB depends on the type and dose of local anesthetics (LA), as well as the use of any additive agent. The selection of LA depends on the type, concentration, and volume of LA. Certain additives, such as dexamethasone, when added to BPB, were shown to increase motor and sensory block duration.

A chart audit conducted by the pharmacy and anesthesia departments revealed a significant variability of clinical practice in the use of LA and additives …

Evidence Based Practice Strategies: Using Price Lists And Peer Coaching To Improve Medication Cost Containment And Documentation Practices In Anesthesia Providers At An Urban Level One Trauma Center, Abigalle Ryan Sparrow

Doctor of Nursing Practice Scholarly Projects

According to the American Association of Nurse Anesthetists (AANA) guidelines for Documenting Anesthesia Care Practice and Policy Considerations, anesthesia provider documentation represents a detailed account of the patient’s anesthesia care during various phases of anesthesia during their hospital stay (Documenting Anesthesia Care: Practice and Policy Considerations, 2016). The primary purpose of anesthesia documentation is to capture accurate and comprehensive information communicating a patient’s anesthetic experience, which includes the documentation of all administered medications. The patient’s electronic or written medical record is a legal document, which is also referenced for reimbursement, quality improvement, and review by external organizations for …

Change For The Ohio Nurse Practitioner Treating Worker's Compensation Patients: A Needs Analysis, Jessica Huff

Doctor of Nursing Practice Scholarly Projects

Autonomous nurse practitioners are an effective and useful member of the healthcare team, particularly when given a less restrictive scope of practice at the state level. The autonomous nurse practitioner can help improve patient outcomes/needs as a decision-making health care team member.

Ohio nurse practitioners treating worker’s compensation patients are limited in treating the injured worker not because of the nurse practitioner scope of practice, but because of the bureaucratic paperwork worker’s compensation requires of its patients/providers. The purpose of the project was to conduct a needs analysis regarding a legislative change proposal for the practice authority of nurse practitioners …

“Strumpet,” “Huswife,” “Whore”: Centering Othello’S Bianca, Phoebe Merten

English (MA) Theses

Is Bianca a sex worker? What meanings change if she is or isn’t? Not enough artistic or critical attention has been paid the character. It seems likely that the initial lack of attention stemmed from Bianca’s status as a purported sex worker, as though this makes her somehow categorically different from the other women in the play, or inherently less interesting. There has in the past decade or so been a marked increase in scholarship on sex work, but this too largely skims over Bianca, likely because of the ambiguity surrounding her profession.

In my introduction I go over some …

Host-Ill, Angelo Mendez

The Prairie Light Review

No abstract provided.

Run, Carlene English

The Prairie Light Review

No abstract provided.

Safe Together, Tim Arroyo

The Prairie Light Review

No abstract provided.

Dusk, Madeleine Church

The Prairie Light Review

No abstract provided.

How Reading Evolved For Me, Hala Al Torkmani

The Prairie Light Review

No abstract provided.

Double Diamond, Jim Water

The Prairie Light Review

No abstract provided.

Wisdom Will Set You Free, Karlette Murray

The Prairie Light Review

No abstract provided.

Haleakala, Mardelle Fortier

The Prairie Light Review

No abstract provided.

Usability And Feasibility Of A Spoken Language Outcome Monitoring Procedure In A Canadian Early Hearing Detection & Intervention Program: Results Of A 1-Year Pilot, Olivia Daub University Of Western Ontario, Bj Cunningham, Marlene P. Bagatto, Janis Oram Cardy

PRECISe Preschool Speech and Language Publications

Purpose: Best practice recommendations for Early Hearing Detection and Intervention (EHDI) programs include routine spoken language outcome monitoring. The present article reports on pilot data that evaluated the usability and feasibility of a spoken language outcome monitoring procedure developed for Ontario’s Infant Hearing Program (IHP). This procedure included both Program-level monitoring using omnibus language tests from birth to 6 years of age and individual vulnerability monitoring of key domains of spoken language known to be at risk in children who are deaf or hard of hearing.

Methodology: Speech-language pathologists (SLPs) in the IHP piloted the new procedures for one year …

May 2022, Maloney Library, Fordham University School Of Law

Maloney Matters

No abstract provided.

The Power Of Mothers And Teachers Engaging In A Mathematics Bilingual Collaboration, Kathleen Jablon Stoehr, Fany Salazar, Marta Civil

Teacher Education

Background:

Making mathematics connections between home and school can have a positive impact on students’ mathematics learning. This is particularly important for students whose experiences and perspectives are underrepresented in school curricula. Although there is evidence for how crucial it is to make connections between mathematics instruction and children’s lived experiences, doing so is often a challenging task for teachers.

Purpose:

This study examines what teachers in two different settings—a dual language school and a Structured English Immersion school—learned from engaging in a mathematics collaboration with Latina mothers. We share the teachers’ perceptions of their students’ and families’ mathematics’ strengths …

Youth Organizing From Within: A Case Study Of A District Youth Equity Council, Amy Elizabeth Nelson

Dissertations

The experiences of Black, indigenous, and person of color (BIPOC) youth in our school systems often share a common thread of having to navigate deficit thinking, institutionalized racism, marginalization, and discrimination (Hammond, 2015; Ladson-Billings, 2016; Roy et al., 2019). While youth organizing has emerged as a potential counter to deficit narratives, it is rarely seen in school settings (Arthurs, 2018; Kirshner & Ginwright, 2012; Roderick et al., 2020; Roy et al., 2019). Using critical race theory as a framework, this case study examined a sample of BIPOC middle and high school students serving on a district Youth Equity Council, their …

School Leadership Through The Covid-19 Pandemic: A Phenomenological Study, Deanna Kay Dykstra-Lathrop

Dissertations

This phenomenological study presented the lived experiences of eight high school principals who led through the COVID-19 pandemic. The participants represented eight different school from five school districts from across Colorado. Each participant’s school implemented 1:1 devices, namely Chromebooks or iPads, for each student prior to the pandemic’s onset. The research question that guided this study was: What are lived experiences of high school principals who led through the COVID-19 pandemic? Data were collected via one-hour, individual, semi-structured interviews in person or via Zoom, then transcribed and analyzed. A phenomenological approach to the data was employed while implementing bridling methods …

An Efficient Computational Method For Causal Inference In High-Dimensional Data: Neighborhood-Based Cross Fitting, Oluwagbenga David Agboola

Dissertations

High-dimensional data are increasingly popular in various physical science and social science disciplines. This study proposed a new computationally efficient sample splitting method called Neighborhood-Based Cross Fitting (NBCF) for double machine learning in causal inference on high-dimensional data. A common existing approach of repeatedly splitting data was suggested to address the overfitting problem in high-dimensional statistics, however it is computationally expensive. The proposed method deals well with the problem of post-selection bias in causal inference in the presence of high-dimensional confounders. Also, it provides an equivalent performance in unbiased estimation as repeated data splitting, which is suggested to expand the …

Mechanistic Undrestanding Of Amorphization In Iron-Based Soft Magnetic Materials, Taban Larimian

ETD Archive

Iron-based magnetic alloys possess very good magnetic and mechanical properties. Among these alloys Fe-Si-B-based alloys show outstanding saturation magnetization and coercivity which makes them great candidates for many industrial applications. Addition of certain elements to the Fe-Si-B base is proven to improve the homogeneity and fineness of microstructure as well as enhance the magnetic behavior of these alloys. In this research work, we have studied the effect of adding copper and niobium to the Fe-Si-B base alloy. Previous studies have shown that magnetic alloys show better magnetic properties when their microstructure consists of nanocrystals embedded in an amorphous matrix. In …

Baseline Survey Of Diatom Assemblages In Freshwater Bodies Of Central Florida, Ashley Mathews

Environmental Studies

Diatoms are well established in their usefulness to determine water quality and habitat assessments. In Central Florida, no research has been devoted to creating a baseline assemblage of freshwater diatoms. This study uses pH, conductivity, water temperature, dissolved oxygen, total nitrogen and total phosphorous to examine the relationship between environmental variables and diatom species composition among eight different sites. Environmental variables were not found to have a statistically significant impact on diatom assemblages in any of the water bodies; however, species composition was significantly different between sites, establishing a baseline of data for further studies to build upon. Although no …

University Of Baltimore Law Forum, Volume 52, Issue 2 (Spring 2022)

University of Baltimore Law Forum

No abstract provided.