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Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern’s Model United Nations Team Returns from New York with National Accolades

An Investigation Of The Interactions Between Tumor-Related Factors, Functional Connectivity Measurements, And Neurologic Function In A Mouse Brain Tumor Model, Inema Epere Orukari

McKelvey School of Engineering Graduate Student Theses & Dissertations

Due to advances in clinical medicine, more children currently diagnosed with a brain tumor become long-term survivors after treatment than in previous decades. As the number of long-term survivors of pediatric brain tumors increases, clinicians and caretakers focus more attention on improving the quality of life of these patients. Unfortunately, a significant proportion of long-term survivors of pediatric brain tumors have cognitive deficits, which reduce their quality of life. Cognitive tests prior to therapy are critical for accurately assessing a patient’s risk of cognitive decline because they provide a pre-treatment baseline for assessing how host, tumor, and treatment factor interact …

Optimizations In The Mri-Guided Adaptive Radiation Therapy Workflow: Towards Mr-Only Rt, Sven Olberg

McKelvey School of Engineering Graduate Student Theses & Dissertations

Technological developments in external beam radiation therapy (RT) made in the past decades have been largely focused on the tight integration of imaging systems and therapy delivery systems in order to enable the precise delivery of therapeutic doses of radiation to internal, complexly shaped targets. Along this line, the adoption of x-ray computed tomography (CT) in the RT workflow and the combination of volumetric cone-beam CT with linacs in the clinical setting brought the practice of image-guided RT (IGRT) to the forefront. Practical limitations related to the poor soft tissue contrast of these x-ray imaging modalities prompted the adoption of …

A Self-Regulating System For Assessing Scientific Predictive Power, Ted C. Rogers

Physics Faculty Publications

I propose a method for tracking and assessing scientific progress using a prediction consensus algorithm designed for the purpose. The protocol obviates the need for centralized referees to generate scientific questions, gather predictions, and assess the accuracy or success of those predictions. It relies instead on crowd wisdom and a system of checks and balances for all tasks. It is intended to take the form of a web-based, searchable database. I describe a prototype implementation that I call Ex Quaerum. The main purpose of the present document is to motivate the project, to explain it's underlying philosophy, to explain the …

Water Use Efficiency In Western Australian Cropping Systems, Martin Harries, Ken C. Flower, Michael Renton, Geoffrey C. Anderson

Grain and Other Field Crops Research Articles

Rotations and associated management practices in rainfed farming systems of southwest Australia have shifted towards intensified cropping. Survey data from 184 fields spanning 14 Mha of southwest Australia were used to document water use efficiency (WUE) and water-limited yield potential (WLYP) of commercial crops and crop sequences and identify biophysical variables influencing WUE. WUE achieved in commercial wheat crops was 10.7 kg grain/ha.mm. Using a boundary function Ywl = 25 × (WU − 45), farmers achieved 54% of WLYP. Climate variables affected WUE more than management and biotic variates, the highest latitude region having WUE of 9.0 kg grain/ha.mm, compared …

Smokejumper Obituary: Hoffman, Ray (Redmond 1967), National Smokejumper Association

Smokejumper Obituaries

No abstract provided.

Diagnostics & Therapeutic Sciences, Georgia Southern University

Clinical Sciences: News & Publications (2018-2023)

• Sock Drive

Characterization Of The Clinical Impact Of A Celiac Disease Algorithm On Diagnostic Workup Of Patients At Beaumont Hospital Royal Oak, Omid Vadpey, Gabriel N. Maine

Posters

INTRODUCTION
Advancements in medical technology and laboratory testing have prompted room for more accurate diagnostic procedures that can aid in diagnostic efficiency, reducing time to diagnosis, unnecessary test ordering, and costs. Celiac Disease is a complex gastrointestinal autoimmune disorder characterized by symptoms that mimic other bowel diseases, such as diarrhea, steatorrhea, and malnutrition. The primary goal of this pilot study is to determine if the implementation of a diagnostic serologic algorithm differs from the current standard of practice for patients that are suspected of celiac disease at Beaumont Health-Royal Oak (BH-RO).

Women And Dada: Reimagining Dada Through The Work Of Beatrice Wood And Sophie Taeuber-Arp, Violet E. Webster

Student Theses and Dissertations

This paper serves to investigate the relationship between the Dada art movement of the early twentieth century and the progression of the women’s liberation movement through the life and works of female Dada artists Sophie Taeuber-Arp and Beatrice Wood. My thesis combines the emergence of modernism and Dada’s utilization of new industrial materials with the reappropriation of material significance seen in Taeuber-Arp’s multi-media work. The first section “Dada Overview” contextualizes both Dada and the post-Victorian evolution of the early twentieth century. In “Beatrice Wood’s Expansion of the Subject” I show how Wood’s work centered around the subconscious narrative of women …

Atrial Fibrillation, Moez Sumar

Advocate GME

No abstract provided.

Aloso: Spectroscopy And Structure Of A New Group Of Astrochemical Molecules, Vincent J. Esposito, Tarek Trabelsi, Joseph S. Francisco

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

No abstract provided.

Game Theory, John Thrasher Iv

Philosophy Faculty Books and Book Chapters

The formal study of strategic interaction known as game theory is one of the most important elements in the PPE toolbox. It is no exaggeration to say that game theory is the fundamental logic at the heart of the social and behavioral sciences, and it is crucial for understanding social and political life. Game theory is the core of modern economic theory, formal models in political science, and the most sophisticated and rigorous approaches to moral and political philosophy. Game theory is also important in many of the natural sciences, especially in theoretical biology. As Herbert Gintis (2009, xiii) puts …

David Phetmanysay, Viola, May 2, 2022 [Program], University Of Northern Iowa. School Of Music.

Music Recital Programs

Program of a music recital given by faculty, students, or guest artists from the School of Music at the University of Northern Iowa.

Duchenne’S Muscular Dystrophy & Occupational Therapy, Vanessa Sagredo, Meagan C. Romero

Client Educational Handouts

No abstract provided.

Dnp Final Report: Skilled Nursing Facility Readmissions: An Evidence-Based Telemedicine Innovation Project, Debra B. Graham

DNP Final Reports

Background: Nationally, 20% of patient readmissions occur within the first 48 hours after arrival to a skilled nurse facility (SNF), and 40-68% of these readmissions are potentially avoidable. Since 2016, the Centers for Medicare and Medicaid penalized SNFs when their return to hospital (RTH) percentages was above national benchmarks. The four SNFs in this project experienced rising transfer rates and diminished RTH percentages since 2017, despite using in-house providers Monday through Friday. Furthermore, there was no provision to address patients’ changes in conditions after hours.

Purpose: This evidence-based practice (EBP) project aimed to standardize the care provided to …

Factors Associated With Endowed Chair Allocation In Medical Oncology In The United States, Lena Jia, Michael Kevin Rooney, Clare E Jacobson, Kent A Griffith, Christina Mangurian, Reshma Jagsi, Merry Jennifer Markham

2020-Current year OA Pubs

To explore persisting gender disparities across leadership roles in medicine, we examined factors associated with holding endowed chairs in US oncology divisions. In 2019, we identified 95 academic oncology divisions, using the Oncology Division Chiefs and Department Chairs listing in the American Society of Clinical Oncology myConnection forum. We collected public information on gender, degree, total National Institutes of Health funding as principal investigator, H-indices, publication and citation numbers, and graduation year and constructed a multivariable logistic regression model. All statistical tests were 2-sided. We identified 1087 oncology full professors. Of these, 287 (26.4%) held endowed chairs: 60 of 269 …

Cross-Species Genetic Screens Identify Transglutaminase 5 As A Regulator Of Polyglutamine-Expanded Ataxin-1, Won-Seok Lee, Ismael Al-Ramahi, Hyun-Hwan Jeong, Youjin Jang, Tao Lin, Carolyn J Adamski, Laura A Lavery, Smruti Rath, Ronald Richman, Vitaliy V Bondar, Elizabeth Alcala, Jean-Pierre Revelli, Harry T Orr, Zhandong Liu, Juan Botas, Huda Y Zoghbi

Duncan NRI Faculty and Staff Publications

Many neurodegenerative disorders are caused by abnormal accumulation of misfolded proteins. In spinocerebellar ataxia type 1 (SCA1), accumulation of polyglutamine-expanded (polyQ-expanded) ataxin-1 (ATXN1) causes neuronal toxicity. Lowering total ATXN1, especially the polyQ-expanded form, alleviates disease phenotypes in mice, but the molecular mechanism by which the mutant ATXN1 is specifically modulated is not understood. Here, we identified 22 mutant ATXN1 regulators by performing a cross-species screen of 7787 and 2144 genes in human cells and Drosophila eyes, respectively. Among them, transglutaminase 5 (TG5) preferentially regulated mutant ATXN1 over the WT protein. TG enzymes catalyzed cross-linking of ATXN1 in a polyQ-length–dependent manner, …

Ndls Communicator: Week Of 05.02.22, Notre Dame Law School

NDLS Communicator

The Latest News

• Rick Garnett and RLI fellow Joseph Graziano write for Newsweek about the Kennedy vs. Bremerton School District Supreme Court case
• Nicole Garnett and 3L student Elizabeth Totzke write op-ed on religious liberty cases for City Journal
• Other Media coverage of Kennedy v. Bremerton RLI case
• Diane Desierto files amicus brief in Supreme Court case
• Avishalom Tor publishes new edited Law and Economics book
• Jeff Pojanowski and Paul Miller on the Private Law Podcast
• Emily Bremer receives award from AALL
• Carter Snead quoted in The Daily Beast
• Yan Yu presents at AALL Law Repositories Caucus conference
• Felicia Caponigri …

Diminished Immune Surveillance During Histologic Progression Of Intraductal Papillary Mucinous Neoplasms Offers A Therapeutic Opportunity For Cancer Interception, Sharia Hernandez, Edwin Roger Parra, Naohiro Uraoka, Ximing Tang, Yu Shen, Mei Jiang, Barbara Mino, Wei Lu, Renganayaki Pandurengan, Cara Haymaker, Kajsa Affolter, Courtney L Scaife, Michele Yip-Schneider, C Max Schmidt, Matthew A Firpo, Sean J Mulvihill, Eugene J Koay, Huamin Wang, Ignacio I Wistuba, Anirban Maitra, Luisa M Solis, Subrata Sen

Faculty, Staff and Student Publications

Purpose: Intraductal papillary mucinous neoplasms (IPMN) are bona fide precursors to pancreatic ductal adenocarcinoma (PDAC). While genomic alterations during multistep IPMN progression have been well cataloged, the accompanying changes within the tumor immune microenvironment (TIME) have not been comprehensively studied. Herein, we investigated TIME-related alterations during IPMN progression, using multiplex immunofluorescence (mIF) coupled with high-resolution image analyses.

Experimental design: Two sets of formalin-fixed, paraffin-embedded tissue samples from surgically resected IPMNs were analyzed. The training set of 30 samples consisted of 11 low-grade IPMN (LG-IPMN), 17 high-grade IPMN (HG-IPMN), and 2 IPMN with PDAC, while a validation set of 93 samples …

Tumor Immune Microenvironment Of Brain Metastases: Toward Unlocking Antitumor Immunity, Matthew R Strickland, Christopher Alvarez-Breckenridge, Justin F Gainor, Priscilla K Brastianos

Faculty, Staff and Student Publications

UNLABELLED: Brain metastasis (BrM) is a devastating complication of solid tumors associated with poor outcomes. Immune-checkpoint inhibitors (ICI) have revolutionized the treatment of cancer, but determinants of response are incompletely understood. Given the rising incidence of BrM, improved understanding of immunobiologic principles unique to the central nervous system (CNS) and dissection of those that govern the activity of ICIs are paramount toward unlocking BrM-specific antitumor immunity. In this review, we seek to discuss the current clinical landscape of ICI activity in the CNS and CNS immunobiology, and we focus, in particular, on the role of glial cells in the CNS …

Genomic Correlates Of Outcome In Tumor-Infiltrating Lymphocyte Therapy For Metastatic Melanoma, Caitlin A Creasy, Yuzhong Jeff Meng, Marie-Andrée Forget, Tatiana Karpinets, Katarzyna Tomczak, Carlos A Torres-Cabala, Amod A Sarnaik, James J Mulé, Levi Garraway, Matias Bustos, Jianhua Zhang, Sapna P Patel, Adi Diab, Isabella C Glitza, Cassian Yee, Hussein Tawbi, Michael K Wong, Jennifer Mcquade, Dave S B Hoon, Michael A Davies, Patrick Hwu, Rodabe N Amaria, Cara Haymaker, Rameen Beroukhim, Chantale Bernatchez

Faculty, Staff and Student Publications

Purpose: Adoptive cell therapy (ACT) of tumor-infiltrating lymphocytes (TIL) historically yields a 40%-50% response rate in metastatic melanoma. However, the determinants of outcome are largely unknown.

Experimental design: We investigated tumor-based genomic correlates of overall survival (OS), progression-free survival (PFS), and response to therapy by interrogating tumor samples initially collected to generate TIL infusion products.

Results: Whole-exome sequencing (WES) data from 64 samples indicated a positive correlation between neoantigen load and OS, but not PFS or response to therapy. RNA sequencing analysis of 34 samples showed that expression of PDE1C, RTKN2, and NGFR was enriched in responders who had improved …

Overall Survival In Phase 3 Clinical Trials And The Surveillance, Epidemiology, And End Results Database In Patients With Metastatic Colorectal Cancer, 1986-2016: A Systematic Review, Chan Shen, Daniel Tannenbaum, Robert Horn, Jane Rogers, Cathy Eng, Benny Johnson, Van Morris, Michael Overman, Christine Parseghian, George J Chang, Maria A Lopez-Olivo, Raghav Kanwal, Lee M Ellis, Arvind Dasari

Faculty, Staff and Student Publications

Importance: Phase 3 trials for patients with metastatic colorectal cancer (mCRC) have been conducted with varying designs and often with surrogate end points for overall survival (OS).

Objectives: To critically examine the factors associated with clinically relevant improvement in OS (defined as ≥2 months) in these trials and to evaluate their association with outcomes reflected in Surveillance, Epidemiology, and End Results (SEER) registry data.

Evidence review: Medline, EMBASE, Cochrane, Web of Science, ClinicalTrials.gov, EU Clinical Trials Register, and the International Clinical Trials Registry Platform were searched for phase 3 trials of systemic therapy for patients with mCRC by decade (1986-1996, …

The Genomic Alterations In Glioblastoma Influence The Levels Of Csf Metabolites, Arnaldo J Santos-López

Faculty, Staff and Student Publications

Primary ciliary dyskinesia (PCD) has been linked to more than 50 genes that cause a spectrum of clinical symptoms, including newborn respiratory distress, sinopulmonary infections, and laterality abnormalities. Although the RSPH4A (c.921+3_6delAAGT) pathogenic variant has been related to Hispanic groups with Puerto Rican ancestry, it is uncertain how frequently other PCD-implicated genes are present on the island. A retrospective chart review of n = 127 genetic reports from Puerto Rican subjects who underwent genetic screening for PCD variants was conducted from 2018 to 2022. Of 127 subjects, 29.1% subjects presented PCD pathogenic variants, and 13.4% were homozygous for the RSPH4A …

Hypomethylating Agent And Venetoclax With Flt3 Inhibitor “Triplet” Therapy In Older/Unfit Patients With Flt3 Mutated Aml, Musa Yilmaz, Hagop Kantarjian, Nicholas J Short, Patrick Reville, Marina Konopleva, Courtney Dinardo, Naveen Pemmaraju, Abhishek Maiti, Elias Jabbour, Nitin Jain, Ghayas Issa, Koichi Takahashi, Koji Sasaki, Maro Ohanian, Sherry Pierce, Guillin Tang, Sanam Loghavi, Keyur Patel, Sa A Wang, Guillermo Garcia-Manero, Michael Andreeff, Farhad Ravandi, Naval Daver

Faculty, Staff and Student Publications

In older/unfit newly diagnosed patients with FLT3 mutated acute myeloid leukemia (AML), lower intensity chemotherapy (LIC) in combination with either a FLT3 inhibitor or with venetoclax results in poor overall survival (median 8 to 12.5 months). We performed a retrospective analysis of 87 newly diagnosed FLT3 mutated AML patients treated on triplet (LIC + FLT3 inhibitor + Venetoclax, [N = 27]) and doublet (LIC + FLT3 inhibitor, [N = 60]) regimens at our institution. Data were collected from prospective clinical trials in 75% (N = 65) and 25% (N = 22) who received the same treatment regimens outside of a …

Service User Experiences Of Occupational Therapy In Acute Mental Health Settings: A Qualitative Evidence Synthesis, Kevin Steede, Rebecca Gough

School of Health Professions

The inclusion of service user perspectives in the development of acute mental health services is recommended in policy. Therefore exploration of their experiences in this setting is merited. This study synthesized qualitative research on service user experiences of occupational therapy in the acute mental health setting using thematic synthesis. The synthesis shows the unique role of occupational therapists in the setting. Service users identified the impact of the profession through environmental transformation, therapeutic relationships, and occupation-focused interventions. Issues of accessibility and availability of interventions were identified. Further research on this topic in a wider range of cultural contexts is recommended.

The Burden Of Mental Health Conditions In Children With Ckd., Katherine L. Kurzinski, Darcy K. Weidemann

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

A Cohort Study Of The Impact Of Covid‐19 On The Quality Of Life Of People Newly Diagnosed With Dementia And Their Family Carers, B Hicks, S Read, B Hu, S Banerjee, Et Al

Peninsula Medical School

Introduction COVID-19 has impacted people with dementia and their family carers, yet little is known about effects on overall quality of life. Methods In a UK cohort study, pre- and post-pandemic data were collected from 114 carers and 93 recently diagnosed people with dementia. Latent growth curve modeling examined change in quality of life. Results Carers reported significant decline in quality of life, although no change was demonstrated by people with dementia. In multivariable analyses, higher levels of cognitive impairment, deprivation, study site, and lower number of memory clinic contacts were associated with greater decline in carer quality of life. …

Everything You Need To Know About 2022 Commencement Ceremonies, Selena Tuilaepa

Lindenlink (2012- )

No abstract provided.

A Smart Yoga Mat System Designed For Visually Impaired People, Dan Han

Theses

Globally, nearly 2.2 billion people are visually impaired, while 39 million are blind at present. Due to various factors, it is difficult for the blind to exercise. Though associations for blind people and disabled schools provide more possibilities for sports training for visually impaired people, these resources cannot reach everyone in need because of location and foundation limits. The project aims to make fitness more accessible for visually impaired people to help them keep healthy. Thus it could support their confidence and independence as they expected. Furthermore, society's awareness of visually impaired people's difficulties while exercising then, more studies could …

Transitional Car Living, Between Homelessness And Permanent Shelter, Isaac Hertzson

Theses

The worsening eviction crisis facing countries like the United States is caused by a variety of factors. The increasing costs of the housing market as large multi-national investing firms speculate on value of housing, to soaring rental prices, stagnating wages, inflation, and the devastation caused by the Covid-19 pandemic. Eviction creates destructive ripple effects throughout society as it often begets a negative feedback loop in which the evicted face housing discrimination leading to further eviction. Eviction is causally linked to issues with both mental and physical well being. To help those facing eviction this project proposes the creation of a …