Digital Commons Network^™

Concerted Type I Interferon Signaling In Microglia And Neural Cells Promotes Memory Impairment Associated With Amyloid Β Plaques, Nicholas E Propson, Rupa Kanchi, Baiping Wang, Cristian Coarfa, Hui Zheng, Wei Cao

Faculty, Staff and Students Publications

The principal signals that drive memory and cognitive impairment in Alzheimer's disease (AD) remain elusive. Here, we revealed brain-wide cellular reactions to type I interferon (IFN-I), an innate immune cytokine aberrantly elicited by amyloid β plaques, and examined their role in cognition and neuropathology relevant to AD in a murine amyloidosis model. Using a fate-mapping reporter system to track cellular responses to IFN-I, we detected robust, Aβ-pathology-dependent IFN-I activation in microglia and other cell types. Long-term blockade of IFN-I receptor (IFNAR) rescued both memory and synaptic deficits and resulted in reduced microgliosis, inflammation, and neuritic pathology. Microglia-specific Ifnar1 deletion attenuated …

Evaluation Of Heat Inactivation Of Human Norovirus In Freshwater Clams Using Human Intestinal Enteroids, Takashi Kamaishi, Ryuichi Sugiyama, Mary K Estes, Masamichi Muramatsu, Kosuke Murakami

Faculty, Staff and Students Publications

Foodborne disease attributed to the consumption of shellfish contaminated with human norovirus (HuNoV) is one of many global health concerns. Our study aimed to determine the conditions of the heat-inactivation of HuNoV in freshwater clams (Corbicula japonica) using a recently developed HuNoV cultivation system employing stem-cell derived human intestinal enteroids (HIEs). We first measured the internal temperature of the clam tissue in a water bath during boiling at 90 °C and found that approximately 2 min are required for the tissue to reach 90 °C. Next, GII.4 HuNoV was spiked into the center of the clam tissue, followed …

Single-Cell Profiling Of Human Dura And Meningioma Reveals Cellular Meningeal Landscape And Insights Into Meningioma Immune Response, Anthony Z Wang, Jay A Bowman-Kirigin, Rupen Desai, Liang-I Kang, Pujan R Patel, Bhuvic Patel, Saad M Khan, Diane Bender, M Caleb Marlin, Jingxian Liu, Joshua W Osbun, Eric C Leuthardt, Michael R Chicoine, Ralph G Dacey, Gregory J Zipfel, Albert H Kim, David G Denardo, Allegra A Petti, Gavin P Dunn

2020-Current year OA Pubs

BACKGROUND: Recent investigations of the meninges have highlighted the importance of the dura layer in central nervous system immune surveillance beyond a purely structural role. However, our understanding of the meninges largely stems from the use of pre-clinical models rather than human samples.

METHODS: Single-cell RNA sequencing of seven non-tumor-associated human dura samples and six primary meningioma tumor samples (4 matched and 2 non-matched) was performed. Cell type identities, gene expression profiles, and T cell receptor expression were analyzed. Copy number variant (CNV) analysis was performed to identify putative tumor cells and analyze intratumoral CNV heterogeneity. Immunohistochemistry and imaging mass …

Rejecting Deconstruction And Welcoming Christian Mysticism: A Review Of When Everything's On Fire, David J. Mulder

Faculty Work Comprehensive List

"This book is an invitation for us to recall and experience the history and tradition of the church that extends far back beyond the modern age."

Posting about ­­­­­­­­the book When Everything's on Fire from In All Things - an online journal for critical reflection on faith, culture, art, and every ordinary-yet-graced square inch of God’s creation.

https://inallthings.org/rejecting-deconstruction-and-welcoming-christian-mysticism-a-review-of-when-everythings-on-fire-faith-forged-from-the-ashes/

Asthma And Technology In Emerging African American Adults (The Athena Project): Protocol For A Trial Using The Multiphase Optimization Strategy Framework, Angela J Jacques-Tiura

Faculty, Staff and Student Publications

BACKGROUND: Asthma causes substantial morbidity and mortality in the United States, particularly among African American emerging adults (AAEAs; aged 18-30 years), but very few asthma programs have targeted this population. Interventions that provide education and address underlying motivation for managing asthma may be the most effective. However, intensive face-to-face interventions are often difficult to implement in this population.

OBJECTIVE: The purpose of this study is to develop an effective mobile asthma management intervention to improve control among AAEAs.

METHODS: We will assess the ability of multiple technologic components to assist and improve traditional asthma education. The first component is the …

Managing The Career Effects Of Discrimination And Motherhood: The Role Of Collegial Support For A Caregiving Policy At A Research-Intensive U.S. University, Amy C. Moors, Abigail J. Stewart, Janet E. Malley

Psychology Faculty Articles and Research

Implementing and encouraging use of policies aimed at creating an equitable higher education workplace for women academics can be challenging. Often, policy usage may be avoided due to stigma or fear of being seen as not committed to one’s workplace, especially for expectant mothers. In the present study, we examined how collegial support for using a tenure clock extension policy affects pre-tenure women’s career outcomes. Among pre-tenure women academics at a large research-intensive institution in the United States (N = 63) who took advantage of the tenure clock extension policy, perceptions of collegial support for using this policy were …

College Of Education News, Georgia Southern University

College of Education: News & Publications (2003-2023)

• ‘A Dream Realized’ with a New M.Ed. in Higher Education

Prevalence Of Anxiety And Depressive Symptoms In Ulcerative Colitis Patients In Jordan And Its Relationship To Patient-Reported Disease Activity, Awni Abu Sneineh, Sara Haj Ali, Ahmad Al-Masri, Amr Diab, Farah Aldweik, Mohammad Darweesh, Mohammad Qaisi, Osama Alshakhatreh, Tarek Tamimi, Yaser Rayyan, Radwan Banimustafa, Ibrahim M. Sablaban

Behavioral Health Articles

Inflammatory bowel disease is associated with higher rates of anxiety and depression compared to the general population. We aimed to determine the prevalence of anxiety and depressive symptoms among patients with ulcerative colitis and correlation to disease activity. In this cross-sectional study, we collected data from 70 consecutive ulcerative colitis patients over one year at our inflammatory bowel disease outpatient clinic through an interview and a questionnaire containing patient demographics and disease characteristics. Anxiety and depressive symptoms were characterized using the Generalized Anxiety Disorder-7 questionnaire and Patient Health Questionnaire-9, respectively, with ulcerative colitis disease severity assessed by the Partial Mayo …

The Value Of Social Capital For The Success Of Spac Ipos, R Haniffa, M Hudaib, T Nawaz

Plymouth Business School

This paper explores the role of social capital in contributing to the success of a new breed of organizations known as ‘blank check companies’ or special purpose acquisition companies (SPACs) that are set up solely to target and acquire listed companies as a fast-track route to gain listing status in the stock market. The paper is a case study of Pershing Square Holdings Ltd., St. Peter Port, UK (PSH), which launched SPAC IPOs (Initial Public Offerings), Pershing Square Tontine Holdings Ltd., New York, NY, USA (PSTH), which succeeded in raising the largest capital from influential investors in 2020. Social capital …

Defining The Effects Of Political Party Symbols On Ballots In Kenya And Its Impact On Kenya's Electoral Process, Machel Yubu Kazungu

Electronic Theses and Dissertations Archive

Design is a huge part of any functional democracy. Many of the most essential forms and documents that connect the government with the citizen are crafted by designers. Good design helps bridge the gap between citizen and government interactions—making them effective and pleasant. Poor design can create a barrier to exercising one’s rights as a citizen. Ballots are one of those official documents; however, they are more essential because they are the only way that the voter can have their voice heard in an election. The purpose of this thesis is to explore the importance of ballot design, the limitations …

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern Graduate Builds Future by Looking to the Past

Beyond The Academy: Readership And Impact Of A White Paper Collection, Angela Hackstadt

University Libraries Faculty Scholarship

In April 2021, members of the NYS Covid-19 and Minority Health Disparities Engaged Researchers Working Group began contributing a series of white papers to a collection in Scholars Archive, University at Albany's institutional repository. This poster reports on the reach of that collection after one year and illustrates the potential for community-focused research published outside of traditional channels.

Centering The Marginalized: The Impact Of The Pandemic On Online Student Retention, Joshua Travis Brown, Joseph M. Kush, Frederick A. Volk

Journal of Student Financial Aid

During the pandemic, much of the focus of administrators and scholars has been on its impact on residential students and the sudden shift to online instruction. While justified, researchers have yet to focus on online students—who often represent marginalized communities in higher education—to ask whether they were impacted by factors related to the pandemic other than the modality shift. In this study, we examined how the first-year retention of online students was affected during the pandemic, and whether it differed from first-year residential students who transitioned online. We examined records of two student cohorts (Fall 2017 and Fall 2019) from …

Gata Now!, Georgia Southern University

Athletics: News & Publications

• GATA Now
• Congrats Graduates
• New Haven Regional
• Last Call
• Season Tickets
• 2022 Football Schedule
• Full Schedule
• Headlines

Proceed With Caution - Rebecca Potts, Rebecca Potts

Professional Practices (ART 399)

Throughout my childhood, my parents often took me out into nature to go hiking, camping, and just explore. Now when I am in nature, I am reminded of my childhood and reflect on the memories of safety and comfort that I experienced, but through the lens of the person that I am today. As I have learned about and engaged with people in my community, I realized that their experiences and views of being outdoors and in the environments that I grew up feeling comfortable in are much different than mine. These different experiences are based on factors such as …

Maximizing Curriculum Mapping With Library Resources, Jason D. Phillips, Andrew Todd

Faculty Scholarship and Creative Works

This presentation was part of UCF's Faculty Center for Teaching & Learning's 2022 Summer Conference. Description: This session will focus on curriculum mapping from a library perspective and highlights several practical applications in course development. Topics will include how to integrate library resources to support textbook affordability and learning outcomes, strategies to ensure that students obtain skills necessary to leverage library databases, and courses to target in order to ensure teaching research through course assignments.

Hyperbranched Polyester-Based Drug Delivery System For The Optical Imaging And Treatment Of Cancer, Truptiben Patel

Electronic Theses & Dissertations

Hyperbranched polymers are well known to be a promising new class of drug delivery system for biomedical application. In this research, a novel hyperbranched polyester polymer was synthesized by following melt polymerization technique utilizing our proprietary A₂B monomer, triethylene glycol and diethylenetriaminepentaacetic acid (DTPA). This polymerization process was catalyzed by p-toluene sulfonic acid and was monitored by analyzing the polymer sample in regular time intervals. The final polymer was purified using the solvent precipitation method and characterized using MALDI-TOF, NMR, and GPC, DSC, TGA, FT-IR. The solvent diffusion method was used to formulate polymeric nanoparticle and doxorubicin drug …

Determinants Of Exclusive Breastfeeding And Mixed Feeding Among Mothers Of Infants In Dubai And Sharjah, United Arab Emirates, Haleama Al Sabbah, Enas A. Assaf, Zainab Taha, Radwan Qasrawi, Hadia Radwan

All Works

Breastfeeding (BF) is considered the ultimate method of infant feeding for at least the first 6 months of life. Exclusive breastfeeding (EBF) is one of the most effective interventions to improve child survival. The main objective of this study was to assess the prevalence and duration of exclusive breastfeeding and the associated factors among women in Dubai and Sharjah, UAE. A cross-sectional study was conducted in four hospitals and four healthcare centers in Dubai and Sharjah between September 2017 and December 2017. Hospitals and centers are governmental and provide maternal and child health services. A convenience sample of 858 Arab …

Swog 1318: A Phase Ii Trial Of Blinatumomab Followed By Pomp Maintenance In Older Patients With Newly Diagnosed Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia, Anjali S. Advani, Anna Moseley, Kristen M. O'Dwyer, Brent L. Wood, Min Fang, Matthew J. Wieduwilt, Ibrahim Aldoss, Jae H. Park, Rebecca B. Klisovic, Maria R. Baer, Wendy Stock, Rupali R. Bhave, Megan Othus, Richard C. Harvey, Cheryl L. Willman, Mark R. Litzow, Richard M. Stone, Elad Sharon, Harry P. Erba

Pathology Research and Scholarship

PURPOSE: Chemotherapy outcomes in older patients with Philadelphia (Ph) chromosome-negative B-acute lymphoblastic leukemia (ALL) are very poor. Here, we evaluated blinatumomab as induction and consolidation therapy followed by prednisone, vincristine, 6-mercaptopurine, and methotrexate (POMP) maintenance chemotherapy in this patient population.

PATIENTS AND METHODS: Patients were treated at National Clinical Trial Network sites. Eligibility criteria included age ≥ 65 years and newly diagnosed Ph chromosome-negative B-ALL. Patients received blinatumomab as induction for one-two cycles until attainment of response (complete remission (CR) and CR with incomplete count recovery). Patients then received three cycles of consolidation with blinatumomab followed by 18 months of …

Tungsten-Enhanced Breast Cancer Metastasis To The Bone Is Associated With Alterations In The Bone Niche., Cameron J. Chock, Alicia Bolt

Pharmaceutical Sciences ETDs

The objective of this thesis project was to investigate the effects of tungsten on breast cancer metastasis to the bone niche, using the 4T1 orthotopic breast cancer model. Oral tungsten (15 ppm) exposure did not affect primary tumor growth. However, following tungsten exposure there were marked changes in the bone niche, including increased metastasis of 4T1 tumor cells and increased osteolysis. Further analysis of the bone niche indicates that enhanced metastasis is associated with a pro-tumorigenic immune suppressive environment, including increased number of granulocytic myeloid derived suppressor cells and increased gene expression of the pro-inflammatory cytokine IL-1β and the activated …

Uab Arts Organizations Recognized With Alabama Arts Alliance Awards, Shannon Thomason

Browse All News

No abstract provided.

Seasonal Variation And Tracking Of Climate Niche Of A Migratory Bird, Javier Gutiérrez Illán, Guiming Wang, D. Tommy King, Fred L. Cunningham

United States Department of Agriculture Wildlife Services: Staff Publications

Migratory birds inhabit different areas during breeding and non-breeding seasons. Depending on the time of the year, they may utilize different resources available in seasonal habitats, but also are subjected to changing climate regimes during their annual life cycle. Migratory birds may adopt ecological niche tracking to cope with different environmental conditions between breeding and non-breeding grounds. The American White Pelican (Pelecanus erythrorhynchos, hereafter ‘AWPE’) is a short-distance migrant between the Gulf of Mexico coastal regions (nonbreeding grounds) and the Northern Great Plains (breeding grounds) of Canada and the US. The American White Pelican is a piscivore, feeding …

The Rise Of Neo-Fascist Populism And Islamophobia In The West, Mohamed Tawfiq Said Tabib

Dissertations and Theses

Trumpism can be defined as racist right-wing neo-fascist populism and nativism combined with a cult of personality. There is very little distinction between neo-fascists, the alt-right, and far-right groups. All can be identified by their socio-political philosophy and vehement beliefs of racial supremacy, ultranationalism, populism, xenophobia, nativism, and anti-immigrant sentiment, as well as being opposed to liberal Western democracy and its values. This thesis explores why there has been a popular international resurgence of far-right neo-fascist movements throughout the European Union and the United States and examines the impact on inter-group social and political relations with those of different racial …

Places To Live: A Multidisciplinary Approach To Modern Maya Houses In Yucatan, Mexico, Virginia J. Ochoa-Winemiller

LSU Doctoral Dissertations

In 1938, Robert C. Wauchope’s Modern Maya Houses provided the first detailed description of traditional rural housing for the Maya area. Until today, no research has attempted to test Wauchope’s notion of cultural continuity in Maya domestic architecture from the prehistoric past up to the time of his pioneering study. By examining data from three municipios located in the state of Yucatan, Mexico, I compared contemporary information collected during visits to residential areas with that published by Wauchope in 1938. An integrated approach to data gathering and analysis, that is, a combination of interviews, questionnaires, archaeological survey, and geographic information …

Monolithically Integrated Microscale Pressure Sensor On An Optical Fiber Tip, Jeremiah C. Williams, Hengky Chandrahalim

AFIT Patents

A passive microscopic Fabry-Pérot Interferometer (FPI) pressure sensor includes an optical fiber and a three-dimensional microscopic optical enclosure. The three-dimensional microscopic optical enclosure includes tubular side walls having lateral pleated corrugations and attached to a cleaved tip of the optical fiber to receive a light signal. An optically reflecting end wall is distally engaged to the tubular side walls to enclose a trapped quantity of gas that longitudinally positions the optically reflecting end wall in relation to ambient air pressure, changing a distance traveled by a light signal reflected back through the optical fiber.

A Genome-Wide Crispr-Cas9 Knockout Screen Identifies Essential And Growth-Restricting Genes In Human Trophoblast Stem Cells, Chen Dong, Shuhua Fu, Rowan M Karvas, Brian Chew, Laura A Fischer, Xiaoyun Xing, Jessica K Harrison, Pooja Popli, Ramakrishna Kommagani, Ting Wang, Bo Zhang, Thorold W Theunissen

2020-Current year OA Pubs

The recent derivation of human trophoblast stem cells (hTSCs) provides a scalable in vitro model system of human placental development, but the molecular regulators of hTSC identity have not been systematically explored thus far. Here, we utilize a genome-wide CRISPR-Cas9 knockout screen to comprehensively identify essential and growth-restricting genes in hTSCs. By cross-referencing our data to those from similar genetic screens performed in other cell types, as well as gene expression data from early human embryos, we define hTSC-specific and -enriched regulators. These include both well-established and previously uncharacterized trophoblast regulators, such as ARID3A, GATA2, and TEAD1 (essential), and GCM1, …

The Heirs Of Malintzin: Gendered Hierarchies In The “Spiritual Conquest” Of Sinaloa, Latin American And Iberian Institute, Jason Dyck

LAII Events

After his death in 1594, Jesuits hailed Gonzalo de Tapia as a proto-martyr of their missions in northwestern New Spain. They did not do the same for María, Tapia’s Indigenous translator who died together with him on the same day in Tovoropa. In this talk, I offer a reconstruction of María’s life by piecing together references to her in Jesuit letters, anuas, relations, and manuscript histories. Questioning the gendered hierarchies of mission histories, I argue that María’s life highlights the important yet often overlooked roles Indigenous women played as lay missionaries in the evangelization of Sinaloa in the late sixteenth …

Creating Positive Lasting Changes With Utah Farmers Markets: Usda Farmers Market Promotion Program Impact Report 2018-2022, Roslynn Mccann, Regan Emmons, Lacee Jimenez, Kelsey Hall, Jaclyn Pace, Celina Wille, Carrie Durward, Mateja R. Savoie-Roskos

All Current Publications

This report identifies ways that farmers markets and direct marketing farmers can address and connect low-income and ethnic-minority populations to healthy food in Utah. It outlines three objectives and highlights program impacts.

Ezh2 Engages Tgfβ Signaling To Promote Breast Cancer Bone Metastasis Via Integrin Β1-Fak Activation, Lin Zhang, Jingkun Qu, Yutao Qi, Yimin Duan, Yu-Wen Huang, Ping Li, Beibei Huang, Shuxing Zhang, Dihua Yu

Faculty, Staff and Student Publications

Bone metastases occur in 50-70% of patients with late-stage breast cancers and effective therapies are needed. The expression of enhancer of zeste homolog 2 (EZH2) is correlated with breast cancer metastasis, but its function in bone metastasis hasn't been well-explored. Here we report that EZH2 promotes osteolytic metastasis of breast cancer through regulating transforming growth factor beta (TGFβ) signaling. EZH2 induces cancer cell proliferation and osteoclast maturation, whereas EZH2 knockdown decreases bone metastasis incidence and outgrowth in vivo. Mechanistically, EZH2 transcriptionally increases ITGB1, which encodes for integrin β1. Integrin β1 activates focal adhesion kinase (FAK), which phosphorylates TGFβ receptor type …

Identification Of Biomarkers Of Response To Preoperative Talazoparib Monotherapy In Treatment Naïve Gbrca+ Breast Cancers, Xuan Liu, Zhongqi Ge, Fei Yang, Alejandro Contreras, Sanghoon Lee, Yiling Lu, Banu K Arun, Stacy L Moulder, Gordon B Mills, Helen Piwnica-Worms, Jennifer K Litton, Jeffrey T Chang

Faculty, Staff and Student Publications

Germline mutations in BRCA1 or BRCA2 exist in ~2-7% of breast cancer patients, which has led to the approval of PARP inhibitors in the advanced setting. We have previously reported a phase II neoadjuvant trial of single agent talazoparib for patients with germline BRCA pathogenic variants with a pathologic complete response (pCR) rate of 53%. As nearly half of the patients treated did not have pCR, better strategies are needed to overcome treatment resistance. To this end, we conducted multi-omic analysis of 13 treatment naïve breast cancer tumors from patients that went on to receive single-agent neoadjuvant talazoparib. We looked …